Automatic analyzer and method for holding down a sample container in an automatic analyzer.

Abstract

To allow for suppressing adhesion between a holding part and a cap when pulling out a piercing needle from the cap.SOLUTION: An automatic analyzer provided herein is configured to collect a sample inside a sample container while a piercing needle is pierced through a cap of the sample container having an upper end sealed with the cap. The automatic analyzer has a holding mechanism. The holding mechanism elastically holds the cap. The holding mechanism also has a suppression function for suppressing the sample container from rising when pulling out the piercing needle from the cap.SELECTED DRAWING: Figure 8

Description

Technical Field

[0001] The embodiments disclosed in this specification and the drawings relate to an automatic analyzer and a method for holding a sample container in the automatic analyzer.

Background Art

[0002] Among automatic analyzers for analyzing blood specimens, there is a blood coagulation analyzer that analyzes target components based on the coagulation characteristics of blood. The blood specimen is stored in a sample container whose upper surface is sealed with a cap. In such an automatic analyzer, prior to inserting a probe for aspirating the blood specimen into the sample container, a pierce needle is used to pierce the cap to avoid clogging of the probe with debris from the cap.

[0003] After aspirating the blood specimen from the sample container, the pierce needle is withdrawn from the cap. For example, the pierce needle is withdrawn from the cap while a pressing component holds the cap from above. At this time, if the pressing component holds the cap with a strong force, the cap may stick to the pressing component, and when the pressing component is lifted to remove it from the cap, the cap and the sample container may float up.

[0004] When the sample container floats up, the sample rack holding the sample container also floats up and then drops. At this time, the position of the sample rack may shift. When the position of the sample rack shifts, the positions of other sample containers held by the sample rack also shift, making it impossible to appropriately aspirate blood specimens from other sample containers. Also, when the sample container floats from the sample rack, the height of the upper end of the sample container increases, and when it is conveyed inside the automatic analyzer, it may contact other members inside the automatic analyzer. These problems can occur not only in blood coagulation type automatic analyzers but also in other automatic analyzers that perform sampling of samples in the sample container with a pierce needle piercing the cap of the sample container.

Prior Art Documents

Patent Documents

[0005] [Patent Document 1] Japanese Patent Publication No. 2016-3970 [Overview of the project] [Problems that the invention aims to solve]

[0006] One of the problems that the embodiments disclosed herein and in the drawings aim to solve is to suppress the adhesion between the retaining part and the cap when the piercing needle is pulled out of the cap. However, the problems that the embodiments disclosed herein and in the drawings aim to solve are not limited to the above problem. Problems corresponding to the effects of each configuration shown in the embodiments described later can also be positioned as other problems. [Means for solving the problem]

[0007] The automated analyzer according to this embodiment is an automated analyzer that performs sampling from a sample container while the cap of the sample container, which is sealed on top by a cap, is punctured with a piercing needle. The automated analyzer has a holding mechanism. The holding mechanism elastically holds the cap down. The holding mechanism also has a suppression function that prevents the sample container from floating up when the piercing needle is withdrawn from the cap. [Brief explanation of the drawing]

[0008] [Figure 1] Figure 1 is a block diagram showing the functional configuration of an example of an automated analyzer according to this embodiment. [Figure 2] Figure 2 shows an example of the analytical mechanism configuration of an automated analyzer. [Figure 3] Figure 3 shows a top view of the measurement section of the analysis mechanism. [Figure 4] Figure 4 is a side view of the measurement unit. [Figure 5] Figure 5 shows another example of the measuring unit, viewed from above. [Figure 6] Figure 6 shows an example of a method for sampling a sample from a sample container. [Figure 7] Figure 7 is a perspective view showing the holding mechanism of an automated analyzer, with the mechanism holding down the cap of the sample container. [Figure 8] Figure 8 is a perspective view showing the entire holding mechanism. [Figure 9] Figure 9 is a magnified perspective view showing a part of the retaining mechanism. [Figure 10] Figure 10 is a side view showing the drive-side component, head-side component, and elastic member of the clamping mechanism. [Figure 11] Figure 11 is a side view showing the drive-side component, head-side component, and elastic member of the clamping mechanism. [Figure 12] Figure 12 is a diagram illustrating a method for detecting the position of the drive-side component. [Figure 13] Figure 13 is a diagram illustrating a method for detecting the position of the drive-side component. [Figure 14] Figure 14 is a diagram illustrating a method for detecting the position of the drive-side component. [Figure 15] Figure 15 is a diagram illustrating a method for detecting the position of the drive-side component. [Modes for carrying out the invention]

[0009] Embodiments will be described below with reference to the drawings. Note that, for the sake of illustration and ease of understanding, the scale and aspect ratios of the drawings attached to this specification have been appropriately altered and exaggerated from those of the actual objects.

[0010] FIG. 1 is a block diagram showing an example of the functional configuration of the automatic analyzer 1 according to the present embodiment. In the present embodiment, the automatic analyzer 1 is, for example, a blood coagulation analyzer. In the following, the present embodiment will be described by taking the automatic analyzer 1 of the blood coagulation type as an example, but the present embodiment can also be realized by an automatic analyzer of other analysis methods. As shown in FIG. 1, the automatic analyzer 1 according to the present embodiment includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a storage circuit 8, a control circuit 9, and a pressing mechanism 10.

[0011] The analysis mechanism 2 generates a mixed solution by mixing a blood sample, which is a sample of a subject, and a coagulation reagent, which is a reagent used for each test item. Further, depending on the test item, the analysis mechanism 2 mixes a standard solution diluted at a predetermined magnification and a reagent used for this test item. The analysis mechanism 2 continuously measures the optical physical property values of the mixed solution of the blood sample and the reagent and the mixed solution of the standard solution and the reagent. By this measurement, for example, standard data and test data represented by transmitted light intensity, absorbance, scattered light intensity, etc. are generated.

[0012] The analysis circuit 3 is a processor that generates calibration data and analysis data regarding the coagulation of a blood sample by analyzing the standard data and the test data generated by the analysis mechanism 2. The analysis circuit 3 reads an analysis program from, for example, the storage circuit 8 and analyzes the standard data and the test data according to the read analysis program. Note that the analysis circuit 3 may include a storage area for storing at least a part of the data stored in the storage circuit 8.

[0013] The drive mechanism 4 drives the analysis mechanism 2 according to the control of the control circuit 9. The drive mechanism 4 is realized by, for example, gears, a stepping motor, a belt conveyor, a lead screw, etc.

[0014] The input interface 5 receives settings such as analysis parameters for each test item related to a blood sample for which measurement is requested from, for example, an operator or via the in-hospital network NW. The input interface 5 is realized, for example, by a mouse, a keyboard, and a touch pad where an instruction is input by touching the operation surface. The input interface 5 is connected to the control circuit 9, converts an operation instruction input from the operator into an electrical signal, and outputs the electrical signal to the control circuit 9. Note that in this specification, the input interface 5 is not limited to only those equipped with physical operation components such as a mouse and a keyboard. For example, an electrical signal processing circuit that receives an electrical signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzer 1 and outputs this electrical signal to the control circuit 9 is also included in the example of the input interface 5.

[0015] The output interface 6 is connected to the control circuit 9 and outputs a signal supplied from the control circuit 9. The output interface 6 is realized, for example, by a display circuit, a printing circuit, and an audio device. The display circuit includes, for example, a CRT display, a liquid crystal display, an organic EL display, an LED display, and a plasma display. Note that a processing circuit that converts data representing the display target into a video signal and outputs the video signal to the outside is also included in the display circuit. The printing circuit includes, for example, a printer. Note that an output circuit that outputs data representing the printing target to the outside is also included in the printing circuit. The audio device includes, for example, a speaker. Note that an output circuit that outputs an audio signal to the outside is also included in the audio device.

[0016] The communication interface 7 is connected to, for example, the in-hospital network NW. The communication interface 7 performs data communication with the HIS (Hospital Information System) via the in-hospital network NW. Note that the communication interface 7 may perform data communication with the HIS via the inspection department system (Laboratory Information System: LIS) connected to the in-hospital network NW.

[0017] The memory circuit 8 includes a magnetic or optical recording medium, or a semiconductor memory, or other recording medium that can be read by the processor. The memory circuit 8 does not necessarily have to be implemented by a single storage device. For example, the memory circuit 8 may be implemented by multiple storage devices.

[0018] The memory circuit 8 stores the analysis program executed by the analysis circuit 3 and the control program for realizing the functions provided in the control circuit 9. The memory circuit 8 stores the calibration data generated by the analysis circuit 3 for each test item. The memory circuit 8 stores the analysis data generated by the analysis circuit 3 for each blood sample. The memory circuit 8 stores the test orders entered by the operator or the test orders received by the communication interface 7 via the hospital network NW.

[0019] The control circuit 9 is a processor that functions as the central hub of the automated analyzer 1. The control circuit 9 implements functions corresponding to the executed program by executing the program stored in the memory circuit 8. The control circuit 9 may also include a memory area that stores at least a portion of the data stored in the memory circuit 8.

[0020] Figure 2 is a schematic diagram showing an example of a part of the configuration of the analytical mechanism 2 shown in Figure 1. As shown in Figure 2, the analytical mechanism 2 according to this embodiment is configured to include a reaction disk 201, a constant temperature unit 202, a rack sampler 203, and a reagent storage unit 204.

[0021] The reaction disk 201 holds multiple reaction vessels 2011 arranged in a ring shape. The reaction vessels 2011 are also called cuvettes. The reaction disk 201 transports the reaction vessels 2011 along a predetermined path. Specifically, during the analysis of a sample, the reaction disk 201 is rotated and stopped alternately at predetermined time intervals by the drive mechanism 4. The reaction vessels 2011 are made of, for example, polypropylene (PP) or acrylic. Although not shown in Figure 2, the automated analyzer 1 has a light-shielding cover that covers the reaction disk 201.

[0022] The constant temperature unit 202 stores a heat transfer medium set to a predetermined temperature and raises the temperature of the mixed liquid contained in the reaction vessel 2011 by immersing the reaction vessel 2011 in the stored heat transfer medium.

[0023] The rack sampler 203 provides movable support for a sample rack 2031 capable of holding multiple sample containers, each containing blood samples that have been requested for measurement. In the example shown in Figure 2, a sample rack 2031 capable of holding five sample containers in parallel is shown.

[0024] The rack sampler 203 is provided with a transport area 2032 for transporting sample racks 2031. That is, using this transport area 2032, the sample racks 2031 are transported from the input position where they are placed to the collection position where the sample racks 2031 are retrieved after measurement is complete. In the transport area 2032, multiple sample racks 2031 aligned in the longitudinal direction are moved in direction D1 by the drive mechanism 4.

[0025] Furthermore, the rack sampler 203 is provided with a retraction area 2033 that retracts the sample rack 2031 from the transport area 2032 in order to move the sample container held by the sample rack 2031 to a predetermined sample aspiration position. The sample aspiration position is set at a position where, for example, the rotational trajectory of the sample dispensing probe 207 and the movement trajectory of the opening of the sample container supported by the rack sampler 203 and held by the sample rack 2031 intersect. In the retraction area 2033, the transported sample rack 2031 is moved in direction D2 by the drive mechanism 4.

[0026] Furthermore, the rack sampler 203 is provided with a return area 2034 for returning the sample rack 2031, which holds the sample container in which the sample has been aspirated, to the transport area. In the return area 2034, the sample rack 2031 is moved in direction D3 by the drive mechanism 4.

[0027] The reagent cabinet 204 holds multiple reagent containers 200 containing standard solutions and reagents used in various tests performed on blood samples, while maintaining a cool temperature. A rotating table is rotatably installed inside the reagent cabinet 204. The rotating table holds the multiple reagent containers 200 in a circular arrangement.

[0028] Furthermore, the analytical mechanism 2 according to this embodiment, shown in Figure 2, comprises a sample dispensing arm 206, a sample dispensing probe 207, a reagent dispensing arm 208, and a reagent dispensing probe 209.

[0029] The sample dispensing arm 206 is positioned between the reaction disk 201 and the rack sampler 203. The sample dispensing arm 206 is provided by a drive mechanism 4 so as to be able to move vertically up and down and rotate horizontally. The sample dispensing arm 206 holds a sample dispensing probe 207 at one end.

[0030] The sample dispensing probe 207 rotates along an arc-shaped rotational trajectory as the sample dispensing arm 206 rotates. A sample aspiration position is provided on this rotational trajectory for aspirating a sample from a sample container held by a sample rack 2031 on the rack sampler 203. Additionally, a sample dispensing position is provided on the rotational trajectory of the sample dispensing probe 207 for dispensing the sample aspirated by the sample dispensing probe 207 into the reaction vessel 2011. The sample dispensing position corresponds, for example, to the intersection of the rotational trajectory of the sample dispensing probe 207 and the movement trajectory of the reaction vessel 2011 held on the reaction disk 201.

[0031] The sample dispensing probe 207 is driven by the drive mechanism 4 and moves vertically at the sample aspiration position or the sample dispensing position. The sample dispensing probe 207 also aspirates a sample from the sample container located directly below the sample aspiration position, according to the control circuit 9. The sample dispensing probe 207 also dispenses the aspirated sample into the reaction vessel 2011 located directly below the sample dispensing position, according to the control circuit 9. These sample dispensing arm 206 and sample dispensing probe 207 constitute an example of the sample dispensing mechanism in this embodiment.

[0032] The reagent dispensing arm 208 is located between the reaction disk 201 and the reagent storage compartment 204. The reagent dispensing arm 208 is provided by a drive mechanism 4 so as to be able to move vertically up and down and rotate horizontally. The reagent dispensing arm 208 holds a reagent dispensing probe 209 at one end.

[0033] The reagent dispensing probe 209 rotates along an arc-shaped rotational trajectory as the reagent dispensing arm 208 rotates. A reagent aspiration position is provided on this rotational trajectory. The reagent aspiration position is, for example, located at the intersection of the rotational trajectory of the reagent dispensing probe 209 and the movement trajectory of the opening of the reagent container 200, which is placed in an annular shape on the rotating table of the reagent storage 204. Additionally, a reagent dispensing position is set on the rotational trajectory of the reagent dispensing probe 209 for dispensing the reagent aspirationd by the reagent dispensing probe 209 into the reaction vessel 2011. The reagent dispensing position corresponds, for example, to the intersection of the rotational trajectory of the reagent dispensing probe 209 and the movement trajectory of the reaction vessel 2011 held on the reaction disk 201.

[0034] The reagent dispensing probe 209 is driven by the drive mechanism 4 and moves vertically at the reagent aspiration position or reagent dispensing position on its rotational trajectory. The reagent dispensing probe 209 also aspirates reagent from the reagent container 200, which is stopped at the reagent aspiration position, according to the control circuit 9. The reagent dispensing probe 209 also dispenses the aspirated reagent into the reaction vessel 2011, which is located directly below the reagent dispensing position, according to the control circuit 9. These reagent dispensing arm 208 and reagent dispensing probe 209 constitute an example of the reagent dispensing mechanism in this embodiment.

[0035] The automated analyzer 1 of this embodiment has a piercing needle 1050 (see Figure 6). The piercing needle 1050 punctures a cap 1010 that seals the top surface of the sample container 1000 in order to aspirate the sample with the sample dispensing probe 207. In this embodiment, the cap 1010 is made of, for example, a rubber stopper so that it can be punctured. The piercing needle 1050 may be held at one end of a piercing needle arm (not shown). The piercing needle arm is provided between the reaction disk 201 and the rack sampler 203, similar to the sample dispensing arm 206. The piercing needle arm is provided by a drive mechanism 4 so that it can move up and down vertically and rotate horizontally.

[0036] The piercing needle 1050 rotates along an arc-shaped rotational trajectory as the piercing needle arm rotates. A sample aspiration position, common to that of the sample dispensing arm 206, is located on the rotational trajectory of the piercing needle arm. The piercing needle 1050 is driven by the drive mechanism 4 and punctures the cap by moving vertically at the sample aspiration position. Thus, the piercing needle arm and the piercing needle 1050 constitute an example of the sample dispensing assistance mechanism in this embodiment.

[0037] Furthermore, in the analysis mechanism 2 according to this embodiment, the same number of photometric units 211 as there are reaction vessels 2011 that can be held in the reaction disk 201 are provided inside. These photometric units 211 constitute the measurement section in this embodiment. Figures 3 and 4 are schematic diagrams showing examples of the configuration of these photometric units 211. Figure 3 is a schematic diagram showing an example of the positional relationship of each component when the photometric unit 211 is viewed from above the reaction disk 201. Figure 4 is a schematic diagram showing an example of the positional relationship of each component when the photometric unit 211 is viewed from the cross-sectional direction of the reaction disk 201.

[0038] The photometric unit 211 continuously measures the optical properties of the mixture of sample and reagent (the substance to be measured) dispensed into the reaction vessel 2011. In the analysis mechanism 2 according to this embodiment, multiple photometric units 211 are provided. For example, the analysis mechanism 2 is provided with the same number of photometric units 211 as there are reaction vessels that can be held by the reaction disk 201. That is, one photometric unit 211 is provided for each reaction vessel held by the reaction disk 201. Since the configuration of each photometric unit 211 is the same, Figures 3 and 4 show one photometric unit 211 as a representative example.

[0039] The photometric unit 211 shown in Figures 3 and 4 includes, for example, a light source 2111 and photodetectors 2112 and 2113. For example, the photometric unit 211 has the light source 2111 on the annular center side of the reaction vessel 2011, which is held annularly by the reaction disk 201. The light source 2111 is positioned to irradiate light toward the outside of the ring in which the reaction vessels 2011 are arranged. Note that the photodetectors 2102 and 2103 may consist of only one of these.

[0040] The light source 2111 is an example of a light irradiation unit that generates light of two different wavelengths. For example, the light source 2111 generates a first light with a longer wavelength and a second light with a shorter wavelength. For example, the wavelength of the first light is included in the red wavelength range of 620 to 750 nm, and the wavelength of the second light is included in the violet to blue wavelength range of 380 to 495 nm. Note that the wavelengths of the first and second light may each be included in the red wavelength range of 620 to 750 nm. The light source 2111 can be realized by, for example, a multi-wavelength LED capable of generating light of multiple wavelengths, two LEDs that each generate light of a predetermined wavelength, and a light source unit that transmits light of a desired wavelength from a wide wavelength range using a filter.

[0041] The light source 2111 generates first and second light according to the control of the control circuit 9. Specifically, for example, the light source 2111 alternately generates first and second light at a predetermined period. In this case, for example, the light source 2111 alternately generates first and second light at a period of 0.05 seconds, which is half of the smallest measurement unit of solidification, for example, 0.1 seconds. The light irradiated from the light source 2111 is incident on the reaction vessel 2011.

[0042] The light source 2111 may generate light of one wavelength specified by the control circuit 9. Alternatively, the light source 2111 may generate the first and second wavelengths of light simultaneously. However, in this case, filters for excluding unwanted wavelengths of light must be provided in the photodetectors 2112 and 2113.

[0043] The photodetector 2112 is positioned opposite the light source 2111, with the reaction vessel 2011 in between. Light emitted from the light source 2111 enters the reaction vessel 2011 from the first side wall and exits from the second side wall opposite the first side wall. The photodetector 2112 detects the light emitted from the reaction vessel 2011. The photodetector 2112 is, for example, an example of a transmitted light receiving unit.

[0044] Specifically, for example, the photodetector 2112 detects light transmitted through a mixture of standard solution and reagent in the reaction vessel 2011. The photodetector 2112 samples the detected light at predetermined time intervals, for example, every 0.1 seconds, and generates standard data represented by transmitted light intensity or absorbance. The predetermined time interval is synchronized, for example, with the frequency of the first light emission. The photodetector 2112 may also be configured to detect only light with a wavelength corresponding to the wavelength of the first light. The photodetector 2112 also detects light transmitted through a mixture of blood sample and reagent in the reaction vessel 2011. The photodetector 2112 samples the detected light at predetermined time intervals and generates test data represented by transmitted light intensity or absorbance. The photodetector 2112 outputs the generated standard data and test data to the analysis circuit 3.

[0045] The photodetector 2113 is positioned so that the irradiation axis of the light source 2111 and the light receiving axis of the photodetector 2113 intersect at approximately 90 degrees within the reaction vessel 2011. Light emitted from the light source 2111 enters the reaction vessel 2011 from the first side wall, is scattered by particles in the mixed liquid, and then exits from the third side wall adjacent to the first side wall at a 90-degree angle. The photodetector 2113 detects the light emitted from the reaction vessel 2011. The photodetector 2113 is, for example, an example of a scattered light receiving unit.

[0046] Specifically, for example, the photodetector 2113 detects light scattered by the mixture of standard solution and reagent in the reaction vessel 2011. The photodetector 2113 samples the detected light at predetermined time intervals, for example, every 0.1 seconds, and generates standard data represented by scattered light intensity, etc. The predetermined time interval is synchronized, for example, with the frequency of the second light emission. The photodetector 2113 may also be configured to detect only light with a wavelength corresponding to the wavelength of the second light, for example. The photodetector 2113 also detects light scattered by the mixture of blood sample and reagent in the reaction vessel 2011. The photodetector 2113 samples the detected light at predetermined time intervals and generates test data represented by scattered light intensity, etc. The photodetector 2113 outputs the generated standard data and test data to the analysis circuit 3.

[0047] The photodetectors 2112 and 2113 may also output the detected light intensity as a detection signal to the analysis circuit 3. In this case, the analysis circuit 3 samples the detection signal at predetermined time intervals, for example, every 0.1 seconds, and generates standard data and test data.

[0048] Figure 5 is a schematic diagram showing another configuration example of the photometric unit 211 according to this embodiment. Similar to Figure 3, Figure 5 shows an example of the positional relationship of each component when the photometric unit 211 is viewed from above the reaction disk 201. The photometric unit 211 shown in Figure 5 has two LEDs 51 and 52 as light sources 2111. In the example shown in Figure 5, the light irradiation axis of LED 52 is tilted by a predetermined angle with respect to the light irradiation axis of LED 51.

[0049] The photodetector 2112 is positioned opposite the LED 51 across the reaction vessel 2011, similar to the examples in Figures 3 and 4. On the other hand, the photodetector 2113 is positioned such that the light irradiation axis of the LED 52 and the light receiving axis of the photodetector 2113 intersect at approximately 90 degrees within the reaction vessel 2011.

[0050] As shown again in Figure 1, the analysis circuit 3 realizes the functions corresponding to the analysis program stored in the memory circuit 8 by executing the analysis program. For example, the analysis circuit 3 has an analysis function 31 and a combined analysis function 32 by executing the analysis program. That is, in this embodiment, the analysis circuit 3 constitutes an analysis processing unit that determines the analysis results of the components contained in the sample based on the results measured by the photometric unit 211. In this embodiment, the case in which the analysis function 31 and the combined analysis function 32 are realized by a single processor is described, but it is not limited to this. For example, the analysis circuit may be configured by combining multiple independent processors, and the analysis function 31 and the combined analysis function 32 may be realized by each processor executing an analysis program.

[0051] The analysis function 31 is a function that analyzes the standard data and test data generated by the analysis mechanism 2, and is an example of an analysis unit. Specifically, for example, in the analysis function 31, the analysis circuit 3 calculates the solidification time based on the standard data and generates calibration data from the calculated solidification time. The analysis circuit 3 outputs the generated calibration data to the control circuit 9.

[0052] Furthermore, in the analysis function 31, the analysis circuit 3 measures the coagulation process in the mixture by, for example, analyzing the test data. Specifically, for example, when analyzing a mixture to which a highly reactive reagent has been added, the analysis circuit 3 analyzes the test data obtained by detecting transmitted light. Based on the test data, the analysis circuit 3 acquires the change in light intensity for the blood coagulation reaction. In the following explanation, the change in light intensity will be described as a reaction curve. The analysis circuit 3 detects the inflection point and the saturation point in the reaction curve as the coagulation termination point. The detection of the inflection point and the saturation point is performed using a mathematical algorithm, for example, the first derivative, second derivative of the reaction curve, or other calculation methods. Based on the detected coagulation termination point, the analysis circuit 3 calculates the coagulation point and the coagulation time, which is the time it takes to reach the coagulation point. In the case of abnormal samples to which coagulation does not proceed after the addition of a highly reactive reagent, the analysis circuit 3 may analyze the test data obtained by detecting scattered light.

[0053] Furthermore, for example, when analyzing a mixture to which a weakly and slowly reacting reagent has been added, the analysis circuit 3 analyzes the test data obtained by detecting scattered light. In this embodiment, the term "weakly reacting reagent" is sometimes used to refer to a reagent that is weakly and slowly reacting, but these terms should be treated as equivalent. Based on the test data, the analysis circuit 3 acquires a reaction curve and calculates information regarding the coagulation of the blood sample, such as the coagulation endpoint, coagulation point, and coagulation time, from the acquired reaction curve.

[0054] Furthermore, depending on the test item, the analysis circuit 3 calculates concentration values, etc., based on the calculated coagulation time and the calibration data for the test item corresponding to this test data. The analysis circuit 3 outputs analysis data, including the coagulation termination point, coagulation point, coagulation time, and concentration values, to the control circuit 9.

[0055] The combined analysis function 32 is a function that combines and analyzes two types of test data generated by the analysis mechanism 2, and is an example of a combined analysis unit. Specifically, in the combined analysis function 32, the analysis circuit 3 acquires test data obtained by detecting transmitted light and test data obtained by detecting scattered light. From the reaction curve based on the test data for transmitted light and the reaction curve based on the test data for scattered light, the analysis circuit 3 calculates information related to the coagulation of the blood sample, such as the coagulation endpoint, coagulation point, and coagulation time.

[0056] The combined analysis function 32 is performed, for example, according to control from the control circuit 9 and the analysis results from the analysis function 31. For example, the analysis circuit 3 performs the combined analysis function 32 in response to instructions from the control circuit 9. In addition, the analysis circuit 3 performs the combined analysis function 32, for example, if the reaction is slower than expected after adding a reagent with a weak reaction in the analysis function 31.

[0057] The analysis circuit 3 outputs analysis data, including the solidification termination point, solidification point, and solidification time, to the control circuit 9.

[0058] The control circuit 9 shown in Figure 1 realizes the functions corresponding to the control program stored in the memory circuit 8 by executing the control program. For example, the control circuit 9 has a system control function 91, a photometric control function 92, a sample aspiration control function 93, and a holding mechanism control function 94 by executing the control program. In this embodiment, the case in which the system control function 91, the photometric control function 92, the sample aspiration control function 93, and the holding mechanism control function 94 are realized by a single processor is described, but it is not limited to this. For example, the control circuit may be configured by combining multiple independent processors, and these various functions may be realized by each processor executing a control program.

[0059] The system control function 91 is a function that comprehensively controls each part of the automatic analyzer 1 based on the input information received from the input interface 5. For example, in the system control function 91, the control circuit 9 controls the analysis circuit 3 to perform analysis according to the inspection item.

[0060] The photometric control function 92 is a function that controls the wavelength of light used for measurement, and is an example of a photometric control unit. Specifically, in the photometric control function 92, the control circuit 9, for example, refers to the test order stored in the memory circuit 8 and obtains reagent information to be used for the next test item to be measured. Based on the test item name, reagent name, reaction information, and retesting information contained in the acquired reagent information, the control circuit 9 determines whether the reaction of the reagent to be used next is weak or not.

[0061] The sample aspiration control function 93 controls the sample dispensing mechanism and sample dispensing assistance mechanism described above to aspirate a predetermined amount of sample from the sample container. Figure 6 shows an example of a method for sampling a sample in the sample container 1000. At the sample aspiration position, the sample aspiration control function 93 moves the piercing needle 1050 downward to puncture the cap 1010 of the sample container 1000, and simultaneously lowers the sample dispensing probe 207 through the inside of the piercing needle 1050 until it reaches the sample 1020, aspirating the sample 1020. After aspirating the sample 1020, the sample dispensing probe 207 is raised to withdraw the sample dispensing probe 207 from the sample container 1000, and then the piercing needle 1050 is raised to withdraw the piercing needle 1050 from the sample container 1000. More specifically, the piercing needle 1050 is withdrawn from the cap 1010.

[0062] The pressing mechanism control function 94 controls the pressing mechanism 10 to press down on the sample container 1000. Specifically, the pressing mechanism control function 94 uses the pressing mechanism 10 to press down on the sample container 1000, with the pressing member 132 of the pressing mechanism 10 contacting the cap 1010 that seals the top surface of the sample container 1000.

[0063] Next, the holding mechanism 10 of the automatic analyzer 1 will be described with reference to Figures 7 to 15. Figure 7 is a perspective view showing the holding mechanism 10 in a state where it is holding down the cap 1010 of the sample container 1000. Figure 8 is a perspective view showing the entire holding mechanism 10, and Figure 9 is a perspective view showing an enlarged part of the holding mechanism 10. Figures 10 and 11 are side views showing the drive-side component 120, the head-side component 130, and the elastic member 140 of the holding mechanism 10. Figures 12 to 15 are diagrams illustrating the method for detecting the position of the drive-side component 120.

[0064] The holding mechanism 10 is a mechanism that holds down the sample container 1000 when performing sampling by aspirating the sample 1020 contained in the sample container 1000 using the sample dispensing probe 207. The sample 1020 is, for example, a blood sample. As shown in Figure 7, the sample container 1000 is placed in the sample aspiration position while being held in the sample rack 2031. The holding mechanism 10 has a holding member 132, which contacts the sample container 1000 to hold it down. In particular, in this embodiment, the top surface of the sample container 1000 is sealed by a cap 1010. Therefore, the holding member 132 holds down the sample container 1000 by pressing down on the cap 1010.

[0065] The pressing mechanism 10 includes a drive-side component 120, a head-side component 130, and an elastic member 140. The pressing mechanism 10 of this embodiment also includes a drive source 110 for driving the drive-side component 120, and a shaft 115 connecting the drive source 110 and the drive-side component 120.

[0066] The drive source 110 is, for example, a motor. The drive source 110 is fixed to, for example, the housing of the holding mechanism 10. However, it is not limited to this, and the drive source 110 may be fixed to the housing of the automatic analyzer 1, etc. The central axis of the shaft 115 extends along a first direction d1. The first direction d1 is, for example, parallel to the vertical direction. The drive source 110 is configured to rotate the shaft 115 about its central axis. A male screw portion is formed on the outer surface of the shaft 115.

[0067] The drive-side component 120 has a female threaded portion that screws into the male threaded portion of the shaft 115. As a result, when the shaft 115 rotates around its central axis, the drive-side component 120 can move along the first direction d1 relative to the drive source 110 and the shaft 115, depending on the direction of rotation. In particular, in this embodiment, the drive source 110 rotates the shaft 115, causing the drive-side component 120 to move up and down along the first direction d1.

[0068] The head-side component 130 is configured to be movable relative to the drive-side component along a first direction d1. In particular, in this embodiment, the head-side component 130 can move up and down along the first direction d1 relative to the drive-side component 120. The head-side component 130 is not connected (screwed) to the male threaded portion of the shaft 115. The head-side component 130 has a retaining member 132. The retaining member 132 contacts the cap 1010 of the sample container 1000 when the head-side component 130 is lowered, and moves away from the cap 1010 when the head-side component 130 is raised. The drive-side component 120 may be composed of a single component or a combination of multiple components. Similarly, the head-side component 130 may be composed of a single component or a combination of multiple components.

[0069] An elastic member 140 is stretched between the drive-side component 120 and the head-side component 130. In this embodiment, the elastic member 140 is a tension coil spring having hooks at both ends. However, the elastic member 140 is not limited to a tension coil spring. The drive-side component 120 has a drive-side latching portion 122. The head-side component 130 also has a head-side latching portion 134. The elastic member 140 is stretched between the drive-side component 120 and the head-side component 130 by having one hook latched to the drive-side latching portion 122 and the other hook latched to the head-side latching portion 134.

[0070] Figure 10 shows the drive-side component 120 and the head-side component 130 in contact with each other along the first direction d1, while Figure 11 shows the drive-side component 120 and the head-side component 130 separated from each other along the first direction d1. In the state shown in Figure 10, it is preferable that the elastic member 140 is slightly stretched. This makes it possible to suppress unintended movement of the head-side component 130 relative to the drive-side component 120, so-called rattling, in the state shown in Figure 10.

[0071] The retaining mechanism 10 of this embodiment has a stopper mechanism 124 that provides a suppression function to prevent the sample container 1000 from floating up when the piercing needle 1050 is pulled out from the cap 1010. The stopper mechanism 124 prevents the sample container 1000 from floating up by preventing the drive-side component 120 and the head-side component 130 from separating from each other by more than a predetermined distance. The stopper mechanism 124 consists of a head-side hooking portion 134 and an elongated hole 125 provided in the drive-side component 120. In this embodiment, the elongated hole 125 is a hole that penetrates the plate-shaped member 126 included in the drive-side component 120 in the thickness direction. The longitudinal direction of the elongated hole 125 is parallel to the first direction d1.

[0072] The head-side latching portion 134 is positioned within the elongated hole 125. In particular, the head-side latching portion 134 is positioned to penetrate the elongated hole 125 along the thickness direction of the plate-shaped member 126. This restricts the range of movement of the head-side latching portion 134 relative to the plate-shaped member 126 along the first direction d1. This restricts the range of movement of the head-side component 130 relative to the drive-side component 120 along the first direction d1.

[0073] As the drive-side component 120 and the head-side component 130 move away from each other along the first direction d1 from the state shown in Figure 10, the head-side locking portion 134 moves within the elongated hole 125 along the longitudinal direction of the elongated hole 125. When the head-side locking portion 134 comes into contact with the upper end 127 of the elongated hole 125, further movement of the head-side locking portion 134 relative to the plate-shaped member 126 is restricted. This prevents the drive-side component 120 and the head-side component 130 from moving away any further.

[0074] The pressing mechanism 10 has sensors for detecting the height positions of the drive-side component 120 and the head-side component 130. In particular, the pressing mechanism 10 of this embodiment has an initial position sensor 150, a drive-side sensor 128, and a lower limit sensor 160. The initial position sensor 150 and the lower limit sensor 160 are fixed to the housing of the pressing mechanism 10, for example. However, the initial position sensor 150 and the lower limit sensor 160 may be fixed to the housing of the automatic analyzer 1, etc. The drive-side sensor 128 is fixed to the drive-side component 120. Therefore, the drive-side sensor 128 moves up and down together with the drive-side component 120.

[0075] For example, a photosensor can be used as the initial position sensor 150, the drive side sensor 128, and the lower limit sensor 160. A photosensor has a light-emitting unit and a light-receiving unit arranged facing each other, and outputs whether or not the light-receiving unit is detecting light emitted from the light-emitting unit. With such a sensor, as long as the light-receiving unit is detecting light emitted from the light-emitting unit, it can be determined that there is no object blocking the light between the light-emitting unit and the light-receiving unit, and when the light-receiving unit stops detecting light emitted from the light-emitting unit, it can be determined that there is an object blocking the light between the light-emitting unit and the light-receiving unit.

[0076] The holding mechanism 10 is attached to the head-side component 130 and has a detection piece 135 that moves up and down integrally with the head-side component 130. A portion of the detection piece 135 is intended to be detected by either the initial position sensor 150, the drive-side sensor 128, or the lower limit sensor 160. As clearly shown in Figures 13 to 15, the detection piece 135 has a main body portion 136 extending along a first direction d1 and a projection portion 137 projecting laterally from the main body portion 136 (in a direction perpendicular to the first direction d1). The lower end of the main body portion 136 is intended to be detected by the lower limit sensor 160. The projection portion 137 is intended to be detected by the initial position sensor 150 and the drive-side sensor 128. However, the detection piece 135 may have a first protrusion intended to be detected by the initial position sensor 150, and a second protrusion different from the first protrusion intended to be detected by the drive-side sensor 128.

[0077] The lower limit sensor 160 is provided for safety. The lower limit sensor 160 is configured to detect the main body 136 of the detection piece 135. In the holding mechanism 10 of this embodiment, when the lower limit sensor 160 detects the main body 136 of the detection piece 135, it is understood that the drive-side component 120 has moved further down than the lower end position described later. In this case, it is considered that there is some malfunction in the holding mechanism 10, so the operation of the holding mechanism 10 is stopped or the user is notified.

[0078] Next, the operation of the pressing mechanism 10 will be described with reference to Figures 10 to 15. Figure 13 shows the positional relationship between the detection piece 135 and the sensors 128 and 150 when the pressing mechanism 10 is in its initial position. Figure 14 shows the positional relationship between the detection piece 135 and the sensors 128 and 150 when the drive-side component 120 and the head-side component 130 have descended from their initial positions and the pressing member 132 has come into contact with the cap 1010 of the sample container 1000. Figure 15 shows the positional relationship between the detection piece 135 and the sensors 128 and 150 when the drive-side component 120 has been further processed and reached its lower end position. The operation of the pressing mechanism 10, which will be described below, is controlled by the pressing mechanism control function 94 of the control circuit 9.

[0079] In the state shown in Figure 10, the holding mechanism 10 is in its initial position. At this time, the holding member 132 is not in contact with the cap 1010 of the sample container 1000. Also, as shown in Figure 13, the protruding portion 137 of the detection piece 135 is detected by the initial position sensor 150 and the drive-side sensor 128. Here, when we say that any part of the detection piece 135 is detected by sensors 128, 150, and 160, it means that the part in question is blocking the light emitted from the light-emitting portion between the light-emitting portion and the light-receiving portion of sensors 128, 150, and 160, that is, the light-receiving portion of the sensor 128, 150, and 160 is not receiving light emitted from the light-emitting portion.

[0080] With the holding mechanism 10 in its initial position, the sample container 1000 held in the sample rack 2031 is positioned in the sample suction position. Specifically, in Figure 2, the sample rack 2031 is moved from the retraction area 2033 in direction D2 by the drive mechanism 4. After the sample container 1000 containing the sample 1020 to be aspirated is positioned in the sample suction position, the drive source 110 rotates the shaft 115 around its central axis. This causes the drive-side component 120 to move downward. Since an elastic member 140 is stretched between the drive-side component 120 and the head-side component 130, the drive-side component 120 and the head-side component 130 descend together as long as the holding member 132 is not in contact with the sample container 1000 (cap 1010). When the holding mechanism 10 shifts downward from its initial position, the initial position sensor 150 stops detecting the protrusion 137 of the detection piece 135. Note that the initial position sensor 150 and the lower limit sensor 160 are fixed to the housing of the retaining mechanism 10 and therefore do not descend. On the other hand, the drive-side sensor 128 descends together with the drive-side component 120 (see Figure 14).

[0081] When the pressing member 132 contacts the cap 1010 of the sample container 1000, the downward movement of the head-side component 130 stops. Consequently, the downward movement of the detection piece 135 also stops. As the drive source 110 further rotates the shaft 115, the drive-side component 120 descends further. At this time, the drive-side sensor 128 descends relative to the detection piece 135. The elastic member 140, which is stretched between the drive-side latch 122 and the head-side latch 134, is stretched as the drive-side component 120 descends. As a result, the elastic member generates an elastic force acting on the drive-side component 120 and the head-side component 130 in a direction that brings them closer together. Therefore, the pressing mechanism 10 elastically presses the cap 1010 with the pressing member 132.

[0082] When the drive-side sensor 128, which has descended together with the drive-side component 120, stops detecting the protruding portion 137 of the detection piece 135, the press mechanism control function 94 stops the drive of the drive source 110. This stops the descent of the drive-side component 120 (see Figures 11 and 15). The position of the drive-side component 120 at this time is defined as the lower end position. At this time, the elastic member 140 is stretched to its maximum extent, giving the press member 132 the greatest elastic force. The force with which the press member 132 presses the cap 1010 at this time is defined as the first force.

[0083] Here, when the drive-side component 120 is in its lower end position, if the head-side latching portion 134 and the upper end of the elongated hole 125 of the drive-side component 120 are in contact, the driving force of the drive source 110 is transmitted to the pressing member 132 via the contact between the head-side latching portion 134 and the elongated hole 125 of the drive-side component 120. In this case, the pressing member 132 may be pressed against the sample container 1000 with an unintendedly large force. This may cause damage to the sample container 1000. Therefore, when the drive-side component 120 is in its lower end position, it is preferable that the head-side latching portion 134 and the upper end of the elongated hole 125 of the drive-side component 120 are not in contact. That is, it is preferable that a small gap is formed between the head-side latching portion 134 and the upper end of the elongated hole 125 of the drive-side component 120.

[0084] In this state, the piercing needle 1050 is used to puncture the cap 1010 of the sample container 1000, and then the sample dispensing probe 207 is lowered through the inside of the piercing needle 1050 until it reaches the sample 1020, thereby aspirating the sample 1020. After aspirating the sample 1020, the sample dispensing probe 207 is raised and withdrawn from the sample container 1000.

[0085] Subsequently, the piercing needle 1050 is raised and pulled out of the cap 1010. At this time, the frictional force generated between the piercing needle 1050 and the cap 1010 causes the sample container 1000 to float up together with the piercing needle 1050. In this embodiment, the stopper mechanism 124 prevents the sample container 1000 from floating up when the piercing needle 1050 is pulled out of the cap 1010. When the piercing needle 1050 is pulled out of the cap 1010, the head-side component 130 also moves upward together with the sample container 1000. When the head-side component 130 moves upward by the amount of the gap formed between the head-side latching portion 134 and the upper end of the elongated hole 125 of the drive-side component 120, the head-side latching portion 134 comes into contact with the upper end of the elongated hole 125, and further upward movement of the head-side component 130 is suppressed.

[0086] When the drive-side component 120 is in its lower end position, its position is fixed by a second force greater than the first force. If the drive source 110 is a motor, when the drive-side component 120 is in its lower end position, its position is fixed by the excitation torque (second force) of the drive source 110. Therefore, when the head-side latching portion 134 is in contact with the upper end of the elongated hole 125, the piercing needle 1050 can be raised and pulled out of the cap 1010 by pressing down on the cap 1010 with a second force greater than the frictional force generated between the piercing needle 1050 and the cap 1010, thereby pulling out the piercing needle 1050 from the cap 1010. When the piercing needle 1050 is pulled out of the cap 1010, the sample container 1000 (cap 1010) separates from the retaining member 132 and falls into the sample rack 2031.

[0087] When the piercing needle 1050 is used to puncture the cap 1010, and when the sample 1020 in the sample container 1000 is aspirated using the sample dispensing probe 207, the holding mechanism 10 holds the sample container 1000 (cap 1010) with a relatively small first force. This prevents the cap 1010 from sticking to the holding member 132. Therefore, when the piercing needle 1050 is withdrawn from the cap 1010, the cap 1010 detaches smoothly from the holding member 132.

[0088] When the sample container 1000 separates from the retaining member 132, the head-side component 130 descends due to gravity and the elastic force of the elastic member 140, and comes into contact with the drive-side component 120. At this time, the drive-side sensor 128 begins to detect the protrusion 137 of the detection piece 135. Subsequently, the drive source 110 is driven to rotate the shaft 115 in the opposite direction, raising the drive-side component 120 and the head-side component 130. When the initial position sensor 150 detects the protrusion 137 of the detection piece 135, the retaining mechanism control function 94 stops driving the drive source 110. This stops the upward movement of the drive-side component 120 and the head-side component 130 (see Figures 10 and 13).

[0089] In this embodiment, the holding mechanism 10 has a suppression function that prevents the sample container 1000 from floating up when the head-side component 130 is at a position (height) where the head-side latching portion 134 is in contact with the upper end of the elongated hole 125, that is, when the sample container 1000 is at a predetermined position (height) relative to the holding mechanism 10. In other words, the suppression function becomes effective. On the other hand, when the piercing needle 1050 is pulled out from the cap 1010, the head-side component 130 descends and the head-side latching portion 134 moves away from the upper end of the elongated hole 125, so the suppression function stops working. In other words, the suppression function becomes ineffective.

[0090] When the piercing needle 1050 is pulled out of the cap 1010, if the frictional force between the piercing needle 1050 and the cap 1010 is greater than the excitation torque (second force) of the drive source 110, the drive-side component 120 may move upward against the excitation torque of the drive source 110. In this case, the lower end position of the drive-side component 120 when the holding mechanism 10 holds down the next sample container 1000 will change, and there is a risk that the sample container 1000 will not be able to be held down properly.

[0091] In this embodiment, after the piercing needle 1050 is pulled out of the cap 1010, the number of drive pulses in the drive source 110 when the drive-side component 120 returns from the lower end position to the initial position is measured. If the drive-side component 120 moves upward against the excitation torque of the drive source 110 when the piercing needle 1050 is pulled out of the cap 1010, the distance the drive-side component 120 moves along the first direction d1 when returning from the lower end position to the initial position becomes smaller. As a result, the number of drive pulses in the drive source 110 when the drive-side component 120 returns from the lower end position to the initial position falls outside the predetermined range. More specifically, the number of drive pulses in the drive source 110 when the drive-side component 120 returns from the lower end position to the initial position becomes smaller than the predetermined range. Therefore, by measuring the number of drive pulses in the drive source 110 when the drive-side component 120 returns from the lower end position to the initial position, it is possible to determine whether the drive-side component 120 has moved upward against the excitation torque of the drive source 110 when the piercing needle 1050 is pulled out of the cap 1010.

[0092] The automatic analyzer 1 may have a notification means that notifies the user if the number of drive pulses of the measured drive source 110 falls outside a predetermined range. This allows the user to perform maintenance on the retaining mechanism 10. Notification to the user using the notification means can be, for example, a display on a display screen, the illumination or flashing of a lamp, an alarm sound or voice, etc.

[0093] Furthermore, the automated analyzer 1 may stop sampling the sample 1020 in the sample container 1000 if the number of drive pulses of the measured drive source 110 falls outside a predetermined range. This prevents sampling malfunctions caused by being unable to properly hold down the sample container 1000.

[0094] In the above-described embodiment, an example was explained in which photosensors were used as the initial position sensor 150, the drive-side sensor 128, and the lower limit sensor 160. However, sensors 150, 128, and 160 are not limited to photosensors. For example, other sensors such as a sensor that measures the amount of elongation of the elastic member 140 or a sensor that measures the force applied to the elastic member 140 may be used as sensors 150, 128, and 160.

[0095] The automated analyzer 1 of this embodiment is an automated analyzer 1 that performs sampling of a sample 1020 inside a sample container 1000, with the cap 1010 of the sample container 1000 sealed on its top surface by a cap 1010, and includes a pressing mechanism 10 that elastically holds down the cap 1010, and has a suppression function that prevents the sample container 1000 from floating up when the piercing needle 1050 is withdrawn from the cap 1010.

[0096] The automated analyzer 1 of this embodiment is an automated analyzer 1 that performs sampling of a sample 1020 inside a sample container 1000, which has its top surface sealed by a cap 1010, with a piercing needle 1050 puncturing the cap 1010 of the sample container 1000, and has a pressing mechanism 10 that presses down on the cap 1010 with a first force when the piercing needle 1050 punctures the cap 1010, and presses down on the cap 1010 with a second force greater than the first force when the piercing needle 1050 is pulled out of the cap 1010.

[0097] The method for holding down the sample container 1000 in this embodiment is a method for holding down the sample container 1000 in an automated analyzer 1 that performs sampling of the sample 1020 inside the sample container 1000 while the cap 1010 of the sample container 1000, which is sealed on its top surface by a cap 1010, is punctured with a piercing needle 1050, and comprises the steps of elastically holding down the cap 1010 and preventing the sample container 1000 from floating up when the piercing needle 1050 is withdrawn from the cap 1010.

[0098] The method for holding down the sample container 1000 in this embodiment is a method for holding down the sample container 1000 in an automated analyzer 1 that performs sampling of the sample 1020 inside the sample container 1000, with the cap 1010 of the sample container 1000 sealed on its top surface by a cap 1010 having been punctured with a piercing needle 1050, and comprises the steps of: holding down the cap 1010 with a first force when puncturing the cap 1010 with the piercing needle 1050; and holding down the cap 1010 with a second force greater than the first force when withdrawing the piercing needle 1050 from the cap 1010.

[0099] With this method of holding the automated analyzer 1 and sample container 1000, when piercing the cap 1010 with the piercing needle 1050 and when aspirating the sample 1020 inside the sample container 1000 using the sample dispensing probe 207, the sample container 1000 (cap 1010) can be held down with a relatively small force (first force). This prevents the cap 1010 from sticking to the holding member 132. Therefore, when the piercing needle 1050 is withdrawn from the cap 1010, the cap 1010 separates smoothly from the holding member 132. On the other hand, by preventing the sample container 1000 from floating up when the piercing needle 1050 is withdrawn from the cap 1010, or by holding down the cap 1010 with a second force greater than the first force when the piercing needle 1050 is withdrawn from the cap 1010, it becomes possible to properly withdraw the piercing needle 1050 from the cap 1010.

[0100] In the automatic analyzer 1 of this embodiment, the suppression function of the holding mechanism 10 is activated when the sample container 1000 is in a predetermined position relative to the holding mechanism 10.

[0101] In the automated analyzer 1 of this embodiment, the suppression function is disabled after the piercing needle 1050 is withdrawn from the cap 1010.

[0102] With this type of automated analyzer 1, the cap 1010 is pressed down with a relatively large force only when the sample container 1000 is floating, further suppressing the cap 1010 from sticking to the pressing member 132.

[0103] In the automatic analyzer 1 of this embodiment, the pressing mechanism 10 includes a drive-side component 120 driven by a drive source 110, a head-side component 130 that can contact the cap 1010, and an elastic member 140 stretched between the drive-side component 120 and the head-side component 130. The pressing mechanism 10 presses down on the cap 1010 by the elastic force of the elastic member 140 acting between the drive-side component 120 and the head-side component 130.

[0104] With this type of automated analyzer 1, the elastic force of the elastic member 140 can be used to properly hold down the sample container 1000.

[0105] In the automatic analyzer 1 of this embodiment, the drive-side component 120 is movable between an initial position and a lower end position below the initial position, and the holding mechanism 10 measures the number of drive pulses in the drive source 110 when the piercing needle 1050 returns from the lower end position to the initial position after being pulled out of the cap 1010.

[0106] With this type of automated analyzer 1, when the piercing needle 1050 is pulled out of the cap 1010, the frictional force generated between the piercing needle 1050 and the cap 1010 is greater than the driving force of the drive source 110. If the drive-side component 120 moves upward against the excitation torque of the drive source 110, the change in the position of the drive-side component 120 can be detected. Therefore, it is possible to prevent the sample container 1000 from being properly held down by the holding mechanism 10 due to a change in the lower end position of the drive-side component 120 when holding down the next sample container 1000.

[0107] The automatic analysis device 1 of this embodiment has a notification means that notifies the user when the number of measured drive pulses falls outside a predetermined range.

[0108] With this type of automated analysis device 1, the user can receive notifications and perform maintenance on the retaining mechanism 10.

[0109] The automatic analyzer 1 of this embodiment stops sampling when the number of measured drive pulses falls outside a predetermined range.

[0110] With this type of automated analyzer 1, sampling problems caused by being unable to properly hold down the sample container 1000 can be prevented.

[0111] In the above description, the term "processor" refers to circuits such as CPUs (central processing units), GPUs (Graphics Processing Units), Application Specific Integrated Circuits (ASICs), and programmable logic devices (e.g., Simple Programmable Logic Devices (SPLDs), Complex Programmable Logic Devices (CPLDs), and Field Programmable Gate Arrays (FPGAs)). When the processor is a CPU, for example, it implements each processing function by reading and executing a program stored in a memory circuit. On the other hand, when the processor is an ASIC, for example, instead of the program being stored in a memory circuit, the processing function is directly incorporated as a logic circuit within the processor's circuit. In this embodiment, each processor is not limited to being configured as a single circuit; multiple independent circuits may be combined to form a single processor and implement its processing function. Furthermore, the multiple components shown in Figure 1 may be integrated into a single processor to implement its processing function.

[0112] While several embodiments and variations have been described, these embodiments and variations are presented as examples only and are not intended to limit the scope of the invention. These embodiments and variations can be implemented in a variety of other forms, and various omissions, substitutions, modifications, and combinations of embodiments and variations can be made without departing from the spirit of the invention. These embodiments and variations are included in the scope and spirit of the invention, as well as in the claims and their equivalents. [Explanation of Symbols]

[0113] 1 Automatic analyzer 2 Analysis mechanism 3 Analysis circuit 4. Drive mechanism 5 Input Interfaces 6 Output Interfaces 7. Communication Interface 8 Memory circuit 9. Control circuits 10. Retaining mechanism 110 Power source 115 shaft 120 Drive-side parts 122 Drive side latch 124 Stopper mechanism 128 Drive-side sensor 130 Head-side parts 132 Retaining member 134 Head-side latching part 135 detected pieces 140 Elastic members 150 Initial position sensor 200 reagent containers 201 Reaction Disk 202 Constant temperature section 203 Rack Sampler 204 Reagent storage 206 Sample dispensing arm 207 Sample dispensing probe 208 Reagent dispensing arm 209 Reagent dispensing probe 211 Measurement Unit (Photometric Unit) 1000 sample containers 1010 Cap 1020 samples 1050 Pierce needles 2011 Reaction Vessel 2031 Sample Rack 2031a Sample container holding section

Claims

1. An automated analyzer that performs sampling of a sample in a sample container, with the cap of the sample container sealed on the top surface by a cap, while the cap of the sample container is punctured with a piercing needle, A pressing mechanism for elastically holding down the cap, the pressing mechanism having a suppression function to prevent the sample container from floating up when the piercing needle is pulled out from the cap, The aforementioned retaining mechanism is A drive-side component that is movable from the upper surface of the sample container along the downward direction of the sample container, A head-side component is connected to the drive-side component by an elastic member and has a pressing member that is movable from the upper surface of the sample container along the downward direction of the sample container and presses down on the cap, An automatic analyzer having a stopper mechanism having the suppression function that prevents the sample container from floating up by preventing the drive-side component and the head-side component from separating from each other by more than a predetermined distance.

2. The automatic analyzer according to claim 1, wherein the suppression function is enabled when the sample container is in a predetermined position relative to the holding mechanism.

3. The automated analyzer according to claim 1 or 2, wherein the suppression function is disabled after the piercing needle is withdrawn from the cap.

4. The pressing mechanism comprises a drive-side component driven by a drive source, a head-side component capable of contacting the cap, and an elastic member stretched between the drive-side component and the head-side component. The automatic analyzer according to any one of claims 1 to 3, wherein the pressing mechanism presses the cap by the elastic force of the elastic member acting between the drive-side component and the head-side component.

5. The drive-side component is movable between an initial position and a lower end position below the initial position. The automatic analyzer according to claim 4, wherein the holding mechanism measures the number of drive pulses in the drive source when the piercing needle returns from the lower end position to the initial position after it has been pulled out of the cap.

6. The automatic analysis apparatus according to claim 5, further comprising a notification means for notifying the user when the measured number of drive pulses falls outside a predetermined range.

7. The automatic analyzer according to claim 5 or 6, wherein the sampling is stopped when the measured number of drive pulses falls outside a predetermined range.

8. An automated analyzer that performs sampling of a sample in a sample container, with the cap of the sample container sealed on the top surface by a cap, while the cap of the sample container is punctured with a piercing needle, An automatic analyzer having a pressing mechanism that presses down on the cap with a first force when the piercing needle punctures the cap, and presses down on the cap with a second force greater than the first force when the piercing needle is withdrawn from the cap.

9. A method for holding down a sample container in an automated analyzer that performs sampling of a sample inside a sample container, where the cap of the sample container, which is sealed on top by a cap, has been punctured with a piercing needle, The automated analyzer has a pressing mechanism that elastically holds down the cap, and the pressing mechanism has a suppression function that prevents the sample container from floating up when the piercing needle is withdrawn from the cap. The aforementioned retaining mechanism is A drive-side component that is movable from the upper surface of the sample container along the downward direction of the sample container, The head-side component has a pressing member that is connected to the drive-side component by an elastic member and is movable along the downward direction of the sample container from the upper surface of the sample container and presses down on the cap, The aforementioned method, The process of elastically pressing the aforementioned cap, The process includes a step of preventing the sample container from floating up when the piercing needle is withdrawn from the cap, A method for preventing the sample container from floating up, wherein the drive-side component and the head-side component are prevented from separating from each other by a predetermined distance or more.

10. A method for holding down a sample container in an automated analyzer that performs sampling of a sample inside a sample container, where the cap of the sample container, which is sealed on top by a cap, has been punctured with a piercing needle, The process involves pressing down on the cap with a first force when piercing the cap with the piercing needle, A method comprising the step of pressing down on the cap with a second force greater than the first force when pulling the piercing needle out of the cap.

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