Applications of the cell wall skeleton of Nocardia rubra in regenerative medicine

The Nocardia rubra cell wall skeleton addresses the limitations of culturing Ad-MSCs by promoting their proliferation and differentiation, enhancing their therapeutic potential in treating conditions like chronic wounds and tissue damage.

JP7841749B2Active Publication Date: 2026-04-07LIAONING GREATEST BIO PHARM CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2021-01-20
Publication Date
2026-04-07

AI Technical Summary

Technical Problem

The challenge lies in effectively culturing adult stem cells, particularly adipose-derived mesenchymal stem cells (Ad-MSCs), due to their limited numbers, sensitivity to unfavorable conditions like oxygen deficiency and inflammation, which hinders their therapeutic application in treating diseases caused by cell loss or damage.

Method used

Utilizing the cell wall skeleton of Nocardia rubra, derived from Nocardia rubra bacteria, to regulate the proliferation and differentiation of stem cells, including Ad-MSCs, through the development of pharmaceutical compositions and medical devices that enhance their viability and functionality.

Benefits of technology

The Nocardia rubra cell wall skeleton enhances the proliferation, differentiation, and migration of stem cells, improving their therapeutic efficacy in treating conditions such as chronic wounds and tissue damage by mitigating adverse conditions faced by transplanted cells.

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Abstract

The present disclosure relates to the use of a cell wall skeleton of Nocardia rubra in regenerative medicine, specifically, the use of Nocardia rubra (particularly the cell wall skeleton) in promoting stem cell proliferation, stem cell growth, stem cell differentiation, stem cell migration, and improving stem cell survival, where the stem cells are selected from adult stem cells, iPSCs, and mesenchymal stem cells.
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Citation Information

Patent Citations

  • Use of red nocardial cell wall skeleton in preparation of medicine

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  • Use of nocardia rubracell wall skeleton in preparing medicament for treating skin damage and pyogenic infection

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  • Application of Nocardia rubra cell wall skeleton serving as natural killer cell proliferation accelerant

    CN108795859A

  • Application of nocardia rubra cell wall skeleton (N-CWS) in preparation of drugs for treating skin lesions

    CN108938674A