Asymmetric scattering fitting for optimal panel readout in cone-beam computed tomography

Abstract

To estimate scatter in primary region projection data.SOLUTION: An x-ray imaging apparatus and associated methods are provided to receive measured projection data in a primary region and measured scatter data in asymmetric shadow regions and determine an estimated scatter in the primary region based on the measured scatter data in the shadow region(s). The asymmetric shadow regions can be controlled by adjusting the position of a beam aperture center on a readout area of the detector. Penumbra data may also be used to estimate scatter in the primary region.SELECTED DRAWING: None

Description

[Technical Field]

[0001] Cross-reference of related applications This application is a compilation of U.S. Provisional Patent Application No. 62 / 773,712 filed on November 30, 2018 (Agent Reference Number 38935 / 04001), U.S. Provisional Patent Application No. 62 / 773,700 filed on November 30, 2018 (Agent Reference Number 38935 / 04002), and U.S. Provisional Patent Application No. 62 / 796,831 filed on January 25, 2019 (Agent Reference Number 38935 / 04002). Application No. 38935 / 04004); U.S. Provisional Patent Application No. 62 / 800,287 filed on February 1, 2019 (Agent Reference Number 38935 / 04003); U.S. Provisional Patent Application No. 62 / 801,260 filed on February 5, 2019 (Agent Reference Number 38935 / 04006); U.S. Provisional Patent Application No. 62 / 813,335 filed on March 4, 2019 (Agent Reference number 38935 / 04007); U.S. Provisional Patent Application No. 62 / 821,116 filed on March 20, 2019 (Agent reference number 38935 / 04009); U.S. Provisional Patent Application No. 62 / 836,357 filed on April 19, 2019 (Agent reference number 38935 / 04016); U.S. Provisional Patent Application No. 62 / 836,352 filed on April 19, 2019 Claiming interest in 11 U.S. provisional patent applications, including the specification (Agent reference number 38935 / 04017); the specification of U.S. provisional patent application No. 62 / 843,796 filed on May 6, 2019 (Agent reference number 38935 / 04005); and the specification of U.S. provisional patent application No. 62 / 878,364 filed on July 25, 2019 (Agent reference number 38935 / 04008). This application also includes, but is not limited to, Agent No. 38935 / 04019, entitled “MULTIMODAL RADIATION APPARATUS AND METHODS”, Agent No. 38935 / 04020, entitled “APPARATUS AND METHODS FOR SCALABLE FIELD OF VIEW IMAGING USING A MULTI-SOURCE SYSTEM”, and Agent No. 38935 / 04011, entitled “INTEGRATD HELICAL FAN-BEAM COMPUTED TOMOGRAPHY IN IMAGE-GUIDED RADIATION TREATMENT DEVICE”;Related to 10 U.S. non-provisional patent applications filed on the same day, including those titled "COMPUTED TOMOGRAPHY SYSTEM AND METHOD FOR IMAGE IMPROVEMENT USING PRIOR IMAGE" with Attorney Docket No. 38935 / 04010; "OPTIMIZED SCANNING METHODS AND TOMOGRAPHY SYSTEM USING REGION OF INTEREST DATA" with Attorney Docket No. 38935 / 04013; "HELICAL CONE-BEAM COMPUTED TOMOGRAPHY IMAGING WITH AN OFF-CENTERED DETECTOR" with Attorney Docket No. 38935 / 04015; "MULTI-PASS COMPUTED TOMOGRAPHY SCANS FOR IMPROVED WORKFLOW AND PERFORMANCE" with Attorney Docket No. 38935 / 04021; "METHOD AND APPARATUS FOR SCATTER ESTIMATION IN CONE-BEAM COMPUTED TOMOGRAPHY" with Attorney Docket No. 38935 / 04012; "METHOD AND APPARATUS FOR IMPROVING SCATTER ESTIMATION AND CORRECTION IN IMAGING" with Attorney Docket No. 38935 / 04018, and "METHOD AND APPARATUS FOR IMAGE RECONSTRUCTION AND CORRECTION USING INTER-FRACTIONAL INFORMATION" with Attorney Docket No. 38935 / 04022. The contents of all of the above patent applications (if any) and patents (if any) are hereby incorporated by reference in their entirety into this specification.;

[0002] Aspects of the disclosed technology relate to estimating scatter in projection data, and more particularly, to using shadow region data, including asymmetric shadow regions / data from detector readouts, to estimate scatter in primary region projection data, including during cone-beam computed tomography (CT) scans. [Background technology]

[0003] In cone-beam CT, scattering can account for a significant portion of detected photons if a scattering-preventing grid with a wide collimation aperture is not used. Scattering can negatively impact image quality, including contrast and quantitative accuracy. Consequently, scattering measurement, estimation, and correction are applicable to cone-beam CT data processing and image reconstruction, including in the context of image-guided radiotherapy (IGRT). IGRT can utilize medical imaging techniques such as CT to acquire images of patients before, during, and / or after treatment.

[0004] Fitting data within the collimator shadow to predict scattering within the aperture is an effective scattering estimation technique for cone-beam CT (CBCT). Traditionally, this technique requires a considerable amount of data within the collimator shadow from both sides of the primary region for reliable scattering fitting. Furthermore, it may be desirable to reduce the readout range of the detector (panel) to shorten readout time in order to enable scanning at higher frame rates. [Overview of the project]

[0005] In one embodiment, the step of estimating scattering in an X-ray image includes receiving projection data measured from a primary region of an X-ray detector, wherein the primary region of the X-ray detector is directly exposed to a radiation beam from a radiation source during at least one scan; receiving scattering data measured from at least one shadow region of the X-ray detector, wherein the at least one shadow region of the X-ray detector is blocked from direct exposure to the radiation beam; and determining estimated scattering in the measured projection shadow data based on the measured scattering data in the at least one shadow region, wherein the aperture center of the primary region is offset from the readout center of the readout range during at least one scan.

[0006] Features described and / or illustrated in reference to one embodiment may be used in the same or similar manner, and / or in combination with or instead of features of other embodiments, in one or more other embodiments.

[0007] This description of the present invention does not limit in any way the words used in the claims or the claims or the scope of the invention. The words used in the claims have all of their full, ordinary meanings.

[0008] The accompanying drawings incorporated herein and constituting part thereof illustrate embodiments of the present invention and, together with the general description of the invention above and the detailed description below, are useful in illustrating embodiments of the invention. It will be understood that the illustrated element boundaries (e.g., boxes, groups of boxes, or other shapes) represent one embodiment of the boundary. In some embodiments, one element may be designed as multiple elements, or multiple elements may be designed as one element. In some embodiments, an element shown as an internal component of another element may be implemented as an external component, and vice versa. Furthermore, elements may not be drawn to scale. [Brief explanation of the drawing]

[0009] [Figure 1] This is a perspective view of an exemplary X-ray imaging apparatus according to one aspect of the disclosed technology. [Figure 2] This is a schematic diagram of an X-ray imaging device incorporated into an exemplary radiotherapy device according to one aspect of the disclosed technology. [Figure 3] This is a schematic diagram of an exemplary collimated projection onto an X-ray detector. [Figure 4] This is a diagram of an exemplary beam and detector configuration having a symmetrical shadow readout region. [Figure 5] This is a diagram of an exemplary beam and detector configuration having an asymmetric shadow readout region. [Figure 6]This is a diagram of another exemplary beam and detector configuration having an asymmetric shadow readout region. [Figure 7] This is a diagram of another exemplary beam and detector configuration having an asymmetric shadow readout region. [Figure 8] This is a diagram of an exemplary lung phantom projected onto a detector using an exemplary collimator aperture. [Figure 9] This is a diagram of an imaging design showing a data profile across an exemplary lung phantom, as shown in Figure 8, which has a symmetrical shadow readout region. [Figure 10] This is a diagram of an imaging design showing a data profile across an exemplary lung phantom, as shown in Figure 8, which has an asymmetric shadow readout region. [Figure 11] This is a diagram of an exemplary lung phantom projected onto a detector using an exemplary collimator aperture. [Figure 12] This is a data plot across an exemplary lung phantom shown in Figure 11, which has a symmetrical shadow readout region. [Figure 13] This is a data plot across an exemplary lung phantom shown in Figure 11, which has an asymmetrical shadow readout region. [Figure 14] This is a diagram of the imaging design showing the data profile across an exemplary lung phantom in the first scan of a dual scan, as shown in Figure 8. [Figure 15] This is a diagram of the imaging design showing the data profile across an exemplary lung phantom in the second scan of a dual scan, as shown in Figure 8. [Figure 16] This flowchart shows an exemplary method of scattering correction. [Figure 17] This flowchart shows another exemplary method of scattering correction. [Figure 18] This flowchart shows an exemplary method for optimizing asymmetric scanning design. [Figure 19] This flowchart shows an exemplary method of IGRT using a radiotherapy device. [Figure 20]A block diagram showing exemplary image-based pre-delivery steps. [Figure 21] A block diagram showing exemplary data sources that may be utilized during imaging or image-based pre-delivery steps. **DETAILED DESCRIPTION**

[0010] The following includes definitions of exemplary terms that may be used throughout this disclosure. Both the singular and plural forms of all terms are included in each meaning.

[0011] As used herein, "component" can be defined as part of hardware, part of software, or a combination thereof. Part of hardware can include at least a processor and part of a memory, and the memory includes instructions to execute. A component can be associated with a device.

[0012] As used herein, "logic", which is synonymous with "circuit", includes, but is not limited to, hardware, firmware, software, and / or combinations thereof for performing function(s) or operation(s). For example, depending on the desired application or need, logic can include a software-controlled microprocessor, discrete logic such as an application-specific integrated circuit (ASIC), or other programmable logic device and / or controller. Logic can also be fully embodied as software.

[0013] As used herein, "processor" includes, but is not limited to, any combination of one or more of substantially any number of processor systems or stand-alone processors such as microprocessors, microcontrollers, central processing units (CPUs), and digital signal processors (DSPs). A processor can be associated with various other circuits that support the operation of the processor, such as random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), clock, decoder, memory controller, or interrupt controller. These support circuits can be internal or external to the processor or its associated electronic package. The support circuits communicate operably with the processor. The support circuits are not necessarily shown separately from the processor in a block diagram or other drawing.

[0014] As used herein, "signal" includes, but is not limited to, one or more electrical signals such as analog or digital signals, one or more computer instructions, bits, or bitstreams.

[0015] As used herein, "software" includes, but is not limited to, one or more computer-readable and / or executable instructions that cause a computer, processor, logic, and / or other electronic device to function, operate, and / or behave in a desired manner. The instructions can be embodied in various forms such as routines, algorithms, modules, or programs that include separate applications or code from dynamically linked sources or libraries.

[0016] While the above exemplary definitions are provided, it is the applicant's intention that the broadest reasonable interpretation consistent with this specification be used for these and other terms.

[0017] As will be discussed in more detail below, embodiments of the disclosed technology relate to estimating scattering in imaging projection data, including estimating scattering in primary region projection data during cone-beam CT scanning using shadow region data. In some embodiments, radiotherapy delivery devices and methods can utilize an integrated low-energy radiation source for CT for use in conjunction with or as part of IGRT. In particular, for example, radiotherapy delivery devices and methods can combine a low-energy collimated radiation source for imaging in the gantry using rotational (e.g., helical or step-and-shoot) imaging acquisition with a high-energy radiation source for therapeutic procedures.

[0018] Low-energy radiation sources (e.g., kilovolts (kV)) can produce higher quality images than high-energy radiation sources (e.g., megavolts (MV)) can be used for imaging. Images produced at kV energy typically have better tissue contrast than those produced at MV energy. High-quality volumetric imaging may be required for visualization of target and risk organs (OARS), adaptive therapy monitoring, and treatment planning / replanning. In some embodiments, kV imaging systems can also be used for positioning, motion tracking, and / or characterization or correction capabilities.

[0019] The image acquisition method may include, for example, a continuous scan (e.g., along the longitudinal movement of the patient support through the gantry bore, along with a helical source trajectory around the central axis), a discontinuous circular stop-and-reverse scan with incremental longitudinal movement of the patient support, or a step-and-shoot circular scan, or can be used in any other form.

[0020] According to various embodiments, the imaging device collimates a radiation source, for example, using a beamformer, to form a cone beam or a fan beam. In one embodiment, the collimated beam is combined with a gantry that rotates continuously while the patient moves, resulting in helical image acquisition.

[0021] In some embodiments, the time associated with increasing scanning rotation to complete high-quality volumetric images can be mitigated by high gantry rate / speed, high kV frame rate, and / or sparse data reconstruction techniques (e.g., using high-speed slip ring rotation including up to 10 revolutions / minute (rpm), up to 20 rpm, up to 60 rpm, or higher rpm) to provide kV CT imaging on a radiotherapy delivery platform. Detectors (having various column / slice sizes, configurations, dynamic ranges, etc.), scanning pitch, and / or dynamic collimation are additional features in various embodiments, including selectively exposing portions of the detector and selectively defining the active readout region, as will be discussed in detail below. In particular, image quality can be improved by using adjustable beamformers / collimators on an X-ray (low-energy) imaging radiation source and / or by optimizing the detector readout range (by estimating scattering as described later).

[0022] The imaging apparatus and method can provide selective and variable collimation of a radiation beam emitted by a radiation source, including adjusting the radiation beam shape to expose less than the entire active region of the associated radiation detector (e.g., a radiation detector positioned to receive radiation from an X-ray radiation source). For example, the beamformer of the imaging apparatus can adjust the shape of the radiation beam as the pitch changes during helical scanning. By exposing only the primary region of the detector and directing the radiation, the shadowed region of the detector can receive only scattering. Scatter measurements within the shadowed region of the detector (and, in some embodiments, measurements within the penumbra) can be used to estimate the scattering within the primary region of the detector receiving projection data.

[0023] The imaging apparatus and method can provide a selective and variable detector readout region and range, including adjusting the detector readout range to limit the active region of the detector in order to improve the readout speed. For example, less data than the available shadow region data can be read out and used for scattering estimation. Combining selective readout with beamforming enables various optimizations of scattering fitting techniques.

[0024] Referring to Figures 1 and 2, an imaging device 10 (e.g., an X-ray imaging device) is shown. It will be understood that the X-ray imaging device 10 may be associated with and / or integrated with a radiotherapy device (shown in Figure 2) that can be used for a variety of applications including but not limited to IGRT. The X-ray imaging device 10 includes a rotatable gantry system called a gantry 12, which is supported by or otherwise housed within a support unit or housing 14. Gantry as used herein refers to a gantry system comprising one or more gantry (e.g., a ring or C-arm) capable of supporting one or more radiation sources and / or associated detectors as they rotate around a target. For example, in one embodiment, a first radiation source and its associated detector may be mounted on a first gantry of the gantry system, and a second radiation source and its associated detector may be mounted on a second gantry of the gantry system. In another embodiment, two or more radiation sources and associated detectors may also be mounted on the same gantry of the gantry system, including, for example, when the gantry system consists of only one gantry. Various combinations of gantry, radiation source, and radiation detector can be combined with various gantry system configurations to image and / or treat the same volume within the same apparatus. For example, kV and MV radiation sources can be mounted in the same or different gantry of a gantry system and used selectively for imaging and / or treatment as part of an IGRT system. When mounted in different gantry, the radiation sources can rotate independently, but still be able to image the same (or nearly the same) volume simultaneously. The rotatable ring gantry 12 can rotate at 10 rpm or more, as described above. The rotatable gantry 12 defines a gantry bore 16 into which a patient can be moved and positioned for imaging and / or treatment.According to one embodiment, the rotatable gantry 12 is configured as a slip-ring gantry that provides continuous rotation of the imaging radiation source (X-rays) and associated radiation detector while providing sufficient bandwidth for high-quality imaging data received by the detector. The slip-ring gantry can eliminate alternating gantry rotations to wind up and unwind cables carrying power and signals associated with the device. Such a configuration enables continuous helical computed tomography, including CBCT, even when integrated into an IGRT system.

[0025] The patient support 18 is positioned adjacent to the rotatable gantry 12 and is configured to support the patient, typically in a horizontal position, for longitudinal movement into and within the rotatable gantry 12. The patient support 18 can move the patient, for example, in a direction perpendicular to the rotation plane of the gantry 12 (along or parallel to the rotation axis of the gantry 12). The patient support 18 can be operably coupled to a patient support controller for controlling the movement of the patient and the patient support 18. The patient support controller can be synchronized with the rotatable gantry 12 and radiation sources mounted on the rotatable gantry for rotation of the patient around its longitudinal axis according to a commanded imaging and / or treatment plan. The patient support can also be moved up, down, left, and right within a limited range once inside the bore 16 to adjust the patient's position for optimal treatment. Axes x, y, and z are shown, and when viewed from the front of the gantry 12, the x-axis is horizontal and points to the right, the y-axis points to the gantry plane, and the z-axis is vertical and points upward. The x, y, and z axes follow the right-hand rule.

[0026] It will be understood that other variations can be adopted without departing from the scope of the disclosed technology. For example, the rotatable gantry 12 and patient support 18 can be controlled to rotate back and forth (e.g., alternating clockwise and counterclockwise rotations) (not continuously as described above) around the patient supported on the patient support, when the support is controlled to move (at a constant or variable speed) relative to the rotatable gantry 12. In another embodiment, a continuous step-and-shoot circular scan alternates the longitudinal (step) movement of the patient support 18 with scanning rotations by the rotatable gantry 12 (shoot) until the desired volume is captured. Device 10 is capable of volume-based and planar-based image acquisition. For example, in various embodiments, device 10 can be used to acquire volumetric and / or planar images and perform the associated processing methods described below.

[0027] Various other types of radiation source and / or patient support movements can be used to achieve relative motion between the radiation source and the patient for generating projection data. Discontinuous motion of the radiation source and / or patient support, continuous but variable / non-constant (including linear and non-linear) linear motion, velocity, and / or trajectory, as well as combinations thereof, can be used, including in combination with various embodiments of the radiotherapy device 10 described above.

[0028] As shown in Figure 2, the X-ray imaging apparatus 10 includes an imaging radiation source 30 coupled to a rotatable gantry 12 or otherwise supported. The imaging radiation source 30 emits a radiation beam (shown collectively as 32) for producing high-quality images. In this embodiment, the imaging radiation source is an X-ray source 30 configured as a kiloelectron volt (kV) source (e.g., a clinical X-ray source with energy levels ranging from about 20 kV to about 150 kV). In one embodiment, the kV radiation source includes kiloelectron volt peak photon energies (keV) up to 150 keV. The imaging radiation source can be any type of transmission source suitable for imaging. For example, the imaging radiation source may be, for instance, an X-ray source (including one for CT), or any other method of generating photons with sufficient energy and flux (e.g., a gamma-ray source (e.g., cobalt-57, with an energy peak at 122 keV), an X-ray fluorescence source (e.g., a fluorescence source passing through the Pb k-line, with two peaks at about 70 keV and about 82 keV). References to X-rays, X-ray imaging, X-ray imaging sources, etc., herein are illustrative of specific embodiments. Other imaging transmission sources can be interchangeably used in various other embodiments.

[0029] The X-ray imaging apparatus 10 may also include another radiation source 20 coupled to a rotatable gantry 12 or supported in another manner. According to one embodiment, the radiation source 20 is configured as a therapeutic radiation source, such as a high-energy radiation source used to treat a tumor in a patient within a target area. Without departing from the scope of the disclosed art, it will be understood that the therapeutic radiation source may be a high-energy X-ray beam (e.g., a megavoltage (MV) X-ray beam) and / or a high-energy particle beam (e.g., a beam of electrons, a beam of protons, or a beam of heavier ions such as carbon) or another suitable form of high-energy radiation. In one embodiment, the radiation source 20 includes a megaelectronvolt peak photon energy (MeV) of 1 MeV or greater. In one embodiment, the high-energy X-ray beam has an average energy greater than 0.8 MeV. In another embodiment, the high-energy X-ray beam has an average energy greater than 0.2 MeV. In another embodiment, the high-energy X-ray beam has an average energy greater than 150 keV. Typically, the radiation source 20 has a higher energy level (peak and / or average, etc.) than the imaging radiation source 30.

[0030] In one embodiment, the radiation source 20 is a LINAC that generates therapeutic radiation (e.g., MV), and the imaging system includes a separate imaging radiation source 30 that generates relatively low-intensity, low-energy imaging radiation (e.g., kV). In other embodiments, the radiation source 20 may also be a radioisotope, such as Co-60, which can typically have an energy of >1 MeV. The radiation source 20 can emit one or more radiation beams (shown collectively in 22) toward a region of interest (ROI) within the patient supported on a patient support 18 according to a treatment plan.

[0031] In some embodiments, the radiation sources 20 and 30 can be used in combination to provide higher quality and better usable images. In other embodiments, at least one additional radiation source can be coupled to the rotatable gantry 12 and operated to acquire projection data at a peak photon energy different from the peak photon energies of the radiation sources 20 and 30.

[0032] Figures 1 and 2 show an X-ray imaging apparatus 10 in which a radiation source 30 is mounted on a ring gantry 12, but other embodiments may include other types of rotatable imaging apparatuses, such as C-arm gantry and robotic arm-based systems. In a gantry-based system, the gantry rotates the imaging radiation source 30 around an axis passing through an isocenter. A gantry-based system includes a C-arm gantry, in which the imaging radiation source 30 is cantilever-mounted on an axis passing through an isocenter and rotates around that axis. A gantry-based system further includes a ring gantry having an overall toroidal shape, such as a rotatable gantry 12, in which the patient's body extends through a ring / toroidal bore, and the imaging radiation source 30 is mounted around the ring and rotates around an axis passing through an isocenter. In some embodiments, the gantry 12 rotates continuously. In other embodiments, the gantry 12 utilizes a cable-based system that rotates and reverses repeatedly.

[0033] The detector 34 (e.g., a two-dimensional plane detector or a curved detector) can be coupled to or otherwise supported by the rotatable gantry 12. The detector 34 (e.g., an X-ray detector) is positioned to receive radiation from the X-ray source 30 and can rotate with the X-ray source 30. The detector 34 can detect or otherwise measure the amount of unattenuated radiation and thus estimate the amount actually attenuated by the patient or associated patient ROI (compared to the initially generated amount). The detector 34 can detect or otherwise collect attenuation data from different angles as the radiation source 30 rotates and emits radiation toward the patient.

[0034] It will be understood that the detector 34 can take on several configurations without departing from the scope of the disclosed technology. As shown in Figure 2, the detector 34 can be configured as a flat panel detector (e.g., a multi-row flat panel detector). According to another exemplary embodiment, the detector 34 can be configured as a curved detector.

[0035] A collimator or beamformer assembly (shown collectively as 36) is positioned relative to the imaging (X-ray) source 30 to selectively control and adjust the shape of the radiation beam 32 emitted by the X-ray source 30 in order to selectively expose a portion or area of ​​the active region of the detector 34. The beamformer can also control how the radiation beam 32 is positioned on the detector 34. In one embodiment, the beamformer 36 may have a 1-degree / 1-dimensional motion (e.g., to create thinner or thicker slits). In another embodiment, the beamformer 36 may have a 2-degree / 2-dimensional motion (e.g., to create rectangles of various sizes). In other embodiments, the beamformer 36 may be capable of various other dynamically controlled shapes, including, for example, parallelograms. All of these shapes can be dynamically adjusted during scanning. In some embodiments, the blocking portion of the beamformer can be rotated and translated.

[0036] The beamformer 36 can control the shape of the radiation beam 32 dynamically emitted by the X-ray source 30 in several geometric shapes, including, but not limited to, a fan beam or cone beam having a beam thickness (width) that is as small as the width of a single detector row or includes multiple detector rows that constitute only a portion of the detector's active area. In various embodiments, the beam thickness can expose a larger detector active area of ​​several centimeters. For example, 3-4 centimeters (measured longitudinally in the detector plane) within a 5-6 centimeter detector can be selectively exposed to the imaging radiation 32. In this embodiment, projection image data of 3-4 centimeters can be captured in each readout with approximately 1-2 centimeters of unexposed detector area on one or both sides, and the unexposed detector area can be used to capture scattering data as discussed below.

[0037] In other embodiments, a portion of the active detector may be selectively exposed to imaging radiation. For example, in some embodiments, the beam thickness can be reduced to a range of about 2 cm, 1 cm, less than 1 cm, or similar sizes, including a smaller detector. In other embodiments, the beam thickness can be increased to a range of about 4 cm, 5 cm, more than 5 cm, or similar sizes, including a larger detector. In various embodiments, the exposure-to-active detector area ratio may be 30-90% or 50-75%. In other embodiments, the exposure-to-active detector area ratio may be 60-70%. However, in other embodiments, various other sizes of exposed and active areas or exposure-to-active detector area ratios may be appropriate. The beam and detector may be configured such that the shadowed area of ​​the detector (active but not directly exposed to radiation) is sufficient to capture scattering data beyond the penumbra.

[0038] Various embodiments may include optimization of features that control the selective exposure of the detector (e.g., beam size, beam / aperture center, collimation, pitch, detector readout range, detector readout center, etc.) so that the measured data is sufficient for the primary (exposed) region and the shadowed region, but is also optimized for velocity and dose control. The shape / position of the beamformer 36 and the readout range of the detector 34 can be controlled so that the radiation beam 32 from the X-ray source 30 covers a large portion of the X-ray detector 34, or hardly any portion, based on the specific imaging task and scattering estimation process being performed. Typically, the active region of the detector 34 can be configured to read one or two asymmetrical shadowed regions of the X-ray detector 34 along with the primary region.

[0039] A beamformer can be configured in various ways that allow for adjustment of the shape of the radiation beam 32 emitted by the X-ray source 30. For example, a collimator 36 may be configured to include a set of jaws or other suitable members, which define and selectively adjust the size of the aperture through which the radiation beam from the X-ray source 30 can pass in a collimated form. According to one exemplary configuration, the collimator 36 may include a maxillary and a mandibular portion, in which case the maxillary and mandibular portions are movable in different directions (e.g., parallel directions), thereby adjusting the size of the aperture through which the radiation beam from the X-ray source 30 passes, and also adjusting the beam position relative to the patient to illuminate only the portion of the patient to be imaged for optimized imaging and minimized patient dose. For example, a collimator may be configured as a multi-leaf collimator (MLC) that includes multiple interlaced leaves that are operable to move to one or more positions between a minimum open or closed position and a maximum open position. It will be understood that the leaves can be moved to desired positions in order to achieve a desired shape of the radiation beam emitted by the radiation source. In one embodiment, the MLC is capable of sub-millimeter targeting accuracy.

[0040] According to one embodiment, the shape of the radiation beam 32 from the X-ray source 30 can be changed during image acquisition. In other words, according to one exemplary embodiment, the leaf position and / or aperture width of the beamformer 36 can be adjusted before or during scanning. For example, according to one embodiment, the beamformer 36 can be selectively controlled and dynamically adjusted during the rotation of the X-ray source 30 so that the radiation beam 32 has a shape with sufficient primary / shadow region and is adjusted to include only the target object (e.g., prostate) during imaging. The shape of the radiation beam 32 emitted by the X-ray source 30 can be changed during or after scanning depending on the desired image acquisition obtained based on imaging and / or therapeutic feedback, as will be discussed in more detail below.

[0041] The detector 24 can be coupled to a rotatable gantry 12, or supported in a different manner by this, and positioned to receive radiation 22 from the therapeutic radiation source 20. The detector 24 can detect or otherwise measure the amount of unattenuated radiation, and thus estimate the amount actually attenuated by the patient or associated patient ROI (compared to the initially generated amount). The detector 24 can detect or otherwise collect attenuation data from different angles as the therapeutic radiation source 20 rotates and emits radiation toward the patient.

[0042] It will be further understood that the therapeutic radiation source 20 may include a beamformer or collimator, or may be associated with it in another way. The collimator / beamformer associated with the therapeutic radiation source 20 may be configured in several ways, similar to the collimator / beamformer 36 associated with the imaging source 30.

[0043] The therapeutic radiation source 20 can be mounted, configured, and / or moved in the same plane as the imaging source 30 or in a different plane (offset). In some embodiments, scattering caused by the simultaneous activation of radiation sources 20 and 30 can be reduced by offsetting the radiating planes.

[0044] When integrated with a radiotherapy device, the imaging device 10 can provide images used to set up (e.g., align and / or position), plan, and / or guide a radiation delivery procedure (treatment). Typical setup is achieved by comparing the current (in-treatment) image with pre-treatment imaging information. Pre-treatment imaging information may include, for example, X-ray, CT data, CBCT data, magnetic resonance imaging (MRI) data, positron emission tomography (PET) data, or 3D rotational angiography (3DRA) data, and / or any information obtained from these or other imaging modalities. In some embodiments, the imaging device 10 can track the motion of the patient, target, or ROI during treatment.

[0045] The reconstruction processor 40 can be operably coupled to the detector 24 and / or the X-ray detector 34. In one embodiment, the reconstruction processor 40 is configured to generate a patient image based on radiation received by the detectors 24 and 34 from the radiation sources 20 and 30. It will be understood that the reconstruction processor 40 can be configured to be used to carry out the method described more fully below. The apparatus 10 also contains, but is not limited to, information including processing and reconstruction algorithms and software, imaging parameters, image data from previously or otherwise acquired images (e.g., planning images), treatment plans, etc. It can contain 44 units of memory suitable for storage.

[0046] The imaging device 10 may include an operator / user interface 48, in which case the operator of the imaging device 10 can interact with or otherwise control the imaging device 10 to provide input regarding scanning or imaging parameters, etc. The operator interface 48 may include any suitable input device such as a keyboard, mouse, or voice-activated controller. The imaging device 10 may also include a display 52 or other human-readable element to provide output to the operator of the imaging device 10. For example, the display 52 may allow the operator to observe reconstructed patient images and other information such as imaging or scanning parameters related to the operation of the imaging device 10.

[0047] As shown in Figure 2, the imaging apparatus 10 includes a controller (collectively referred to as 60) operably coupled to one or more components of the apparatus 10. The controller 60 controls the overall function and operation of the apparatus 10, including providing power and timing signals to the imaging source 30 and / or the therapeutic radiation source 20 and the gantry motor controller, which controls the rotational speed and position of the rotatable gantry 12. It will be understood that the controller 60 may encompass one or more of the following: a patient assistance controller, a gantry controller, a controller coupled to the therapeutic radiation source 20 and / or the imaging source 30, a beamformer 36 controller, a controller coupled to the detector 24 and / or the detector 34, etc. In one embodiment, the controller 60 is a system controller that can control other components, devices, and / or controllers.

[0048] In various embodiments, the reconfiguration processor 40, operator interface 48, display 52, controller 60, and / or other components can be combined to form one or more components or devices.

[0049] The apparatus 10 may include various components, logic, and software. In one embodiment, the controller 60 comprises a processor, memory, and software. Not limited to, but as an example, the X-ray imaging apparatus and / or radiotherapy system may include various other devices and components (e.g., gantry, radiation source, collimator, detector, controller, power supply, patient support, etc.) that can perform one or more routines or steps related to imaging and / or IGRT for specific applications, and the routines may include imaging, image-based pre-delivery steps, and / or treatment delivery, including respective device settings, configurations, and / or positions (e.g., paths / trajectories) that can be stored in memory. Furthermore, the controller(s) may directly or indirectly control one or more devices and / or components according to one or more routines or processes stored in memory. An example of direct control is setting various radiation source or collimator parameters (power, velocity, position, timing, modulation, etc.) related to imaging or treatment. An example of indirect control is communication of position, path, velocity, etc. to a patient support controller or other peripheral devices. The various controller hierarchies that may be associated with the imaging device can be arranged in any suitable way to transmit appropriate commands and / or information to the desired devices and components.

[0050] Furthermore, those skilled in the art will understand that the system and method may be implemented in other computer system configurations. Illustrated embodiments of the present invention can be implemented in a distributed computing environment, where specific tasks are performed by local or remote processing devices linked via a communication network. For example, in one embodiment, the reconfiguration processor 40 may be associated with a separate system. In a distributed computing environment, program modules may reside in both local and remote memory storage devices. For example, a remote database, a local database, a cloud computing platform, a cloud database, or a combination thereof may be available to the imaging device 10.

[0051] The imaging apparatus 10 may utilize an exemplary environment for carrying out various aspects of the present invention, including a computer, in which case the computer includes a controller 60 (which may include a processor and memory 44, for example) and a system bus. The system bus can connect system components, including but not limited to memory, to the processor and can communicate with other systems, controllers, components, devices, and the processor. The memory may include read-only memory (ROM), random access memory (RAM), hard drives, flash drives, and any other form of computer-readable media. The memory may store various software and data, including routines and parameters, which may include, for example, treatment plans.

[0052] The therapeutic radiation source 20 and / or imaging source 30 can be operably coupled to a controller 60 configured to control the relative operation of the therapeutic radiation source 20 and the imaging source 30. For example, the imaging source 30 can be controlled and operated simultaneously with the therapeutic radiation source 20. In addition to this, or instead, depending on the specific treatment and / or imaging plan being performed, the imaging source 30 can be controlled and operated sequentially together with the therapeutic radiation source 20. ru.

[0053] It will be understood that the imaging source 30 and detector 34 can be configured to provide rotation around the patient in several ways during imaging scanning. In one embodiment, the motion and exposure of the imaging source 30 can be synchronized with the longitudinal motion of the patient support 18 to provide continuous helical acquisition of patient images during the procedure. In addition to the continuous rotation of the radiation sources 20, 30 and detectors 24, 34 (e.g., continuous and constant rotation of the gantry at a constant patient motion speed), it will be understood that other variations can be employed without departing from the scope of the disclosed art. For example, a rotatable gantry 12 and patient support can be controlled to rotate back and forth (e.g., alternating clockwise and counterclockwise rotations) (not continuously as described above) around a patient supported on the patient support, when the support is controlled to move (at a constant or variable speed) relative to the rotatable gantry 12. In another embodiment, a continuous step-and-shoot circular scan alternates the longitudinal (step) movement of the patient support 18 with scanning rotations by a rotatable gantry 12 (shoot) until the desired volume is captured. The imaging device 10 is capable of volume-based and planar image acquisition. For example, in various embodiments, the imaging device 10 can be used to acquire volumetric and / or planar images (e.g., via the use of an imaging source 30 and a detector 34) and perform associated processing, including scattering estimation / correction methods described later.

[0054] Various other types of radiation source and / or patient support movements can be used to achieve relative motion between the radiation source and the patient for generating projection data. Discontinuous motion, continuous but variable / non-constant (including linear and non-linear) motion, velocity, and / or trajectory of the radiation source and / or patient support, as well as combinations thereof, can be used, including in combination with various embodiments of the radiotherapy device 10 described above.

[0055] In one embodiment, the rotation speed of the gantry 12, the speed of the patient support 18, the shape of the beamformer 36, and / or the readout of the detector 34 may all be constant during image acquisition. In other embodiments, one or more of these variables may change dynamically during image acquisition. The rotation speed of the gantry 12, the speed of the patient support 18, the shape of the beamformer 36, and / or the readout of the detector 34 may be changed to balance various factors, such as image quality and image acquisition time.

[0056] In other embodiments, these features can be combined with one or more other image-based activities or procedures, such as patient setup, adaptive therapy monitoring, and treatment planning.

[0057] Image quality is determined by many factors (e.g., source focal size, detector dynamic range, etc.). The limit of kV CBCT image quality is scattering. Various methods can be used to reduce scattering. One method is to use a scattering prevention grid (to collimate scattering). However, implementing a scattering grid on a kV imaging system that includes motion tracking and correction can be problematic. To improve the quality of image data, it is necessary to accurately estimate the scattering in the projection data. In various embodiments, the scattering in the projection data acquired within the primary region of detector 34 can be estimated based on data measured within the shadow region (and penumbra region) of detector 34.

[0058] Figure 3 is a schematic diagram of an exemplary collimated projection 300 onto the X-ray detector 302. A rotating X-ray source 306 emitting a radiation beam 308 is shown, which exposes a primary or central (C) region 310 of the detector 302 so as the X-ray source rotates around the y-axis, directing the radiation from the X-ray source 306 (for example, to pass through a target). The motion of a patient support (not shown) can be axial (longitudinal) along the y-axis, which is included as part of the scan as described above. The detector 302 also has a rear (B) shadow region 312 and a front (F) shadow region 314 that are blocked from direct exposure to the radiation beam 308 by a beamformer / collimator 320. The beamformer / collimator 320 is configured to adjust the shape and / or position of the radiation beam 308 emitted onto the detector 302 by the X-ray source 306. The shadowed regions 312, 314 receive only scattered radiation.

[0059] The aperture of the collimator 320 is configured such that the rear (B) end 312 and front (F) end 314 of the detector 302 are not directly irradiated by radiation 308 in the axial or longitudinal direction (along the patient table direction or the y-axis). These shadow regions of the rear (B) 312 (negative longitudinal direction along the rotational y-axis) and front (F) 314 (positive longitudinal direction along the rotational y-axis) are not directly irradiated and can therefore be used for scattering measurements. For example, the readout range of the detector 302 can be configured to read out all or part of the data in one or more shadow regions 312, 314 and use the data for scattering estimation in the primary region 310. The primary or central (C) region 310 is subject to both direct projection and scattering.

[0060] A data processing system (e.g., processor 40) can be configured to receive measured projection data within the primary region 310 and measured scattering data within at least one shadow region 312, 314, and then determine the estimated scattering within the primary region 310 based on the measured scattering data within at least one shadow region 312, 314. In some embodiments, determining the estimated scattering within the primary region 310 during the current rotation can be based on measured scattering data within at least one shadow region 312, 314 during adjacent (previous and / or subsequent) rotations. In other embodiments, measured data from penumbra regions (which may define the primary and shadow regions) can also be used for scattering estimation.

[0061] Some embodiments of collimator shadow fitting methods can utilize large amounts of data from both sides of collimator shadow regions 312, 314 for scattering fitting. Measuring large amounts of scattered data within shadow regions 312, 314 can consume a significant amount of processing time and is not necessarily required for reliable scattering fitting (estimation). For example, during CBCT scanning, reducing the detector readout range (including primary and read shadow regions) may be desirable to reduce readout time and enable scanning at higher frame rates. However, when a reduced detector readout range is used and scattering estimation using collimator shadow data fitting is applied, a specific readout range still needs to be allocated to read out data within collimator shadow regions 312, 314. Therefore, to reduce readout time, the effective detector region used for patient data acquisition within the primary region 310 is typically reduced in these embodiments, thereby reducing the effective scanning field. As a result, if a wide axial range of the patient needs to be scanned, additional circular scanning or helical scanning rotation is required. This increases the total scanning time and negatively impacts the treatment workflow and throughput.

[0062] However, in various embodiments described herein, the use of asymmetric data fitting can be used for scattering estimation to mitigate the need to reduce the field of view (FOV). For example, some embodiments use a large amount of data from one side of the collimator shadow and a small amount of data from the other side of the collimator shadow, thereby reducing the entire detector readout range used to read out the data for scattering fitting, effectively increasing the scanning FOV when a limited detector readout range is used (or maintaining the scanning FOV compared to an unreduced detector readout range). This can be called asymmetric scattering fitting.

[0063] Figures 4–7 show schematic diagrams of exemplary detectors in scanning designs with various shadow zones and detector readout ranges. The exemplary detector is positioned to receive radiation from an X-ray source (not shown) emitting a radiation beam, and the detector includes a readout range. A beamformer (not shown) is configured to adjust the shape (or width) and position (center) of the radiation beam emitted by the X-ray source, thereby (as shown, for example, in Figure 3) the primary region of the X-ray detector is directly exposed to the radiation beam, and at least one shadow region of the X-ray detector is blocked from direct exposure to the radiation beam by the beamformer.

[0064] For convenience, the following notation is used to identify the beam region and detector region in these figures along the axial direction (y-axis) of the X-ray imaging device: LD is the axial length of the detector with detector center CD, LA is the axial length of the aperture formed by the beamformer with aperture center CA, and LR is the axial length of the detector readout (active) range with readout center CR. When the beam is projected onto the detector, a primary region with axial length LC equal to LA is created, a back shadow region with axial length LSB, and a forward shadow region with axial length LSF. The back penumbra region with axial length LPB and the forward penumbra region with axial length LPF are located between the primary region and the shadow region. In this way, the beamformer can be configured to project the radiation beam onto the detector such that LD = LSB + LPB + LA + LPF + LSF. Furthermore, the detector's active readout region can be controlled / configured so that only a portion of the shadowed region is read (active), in which case the active back shadow region has axial length LB and the active forward shadow region has axial length LF.

[0065] Figure 4 shows an exemplary beam and detector configuration 400 having a symmetrical shadow readout region. In this configuration, a detector 402 is shown, with the aperture center CA and readout center CR aligned with the detector center CD. Here, the lengths of the active back shadow region LB and the active front shadow region LF are equal and symmetrical on the detector 402.

[0066] As discussed above, various embodiments can utilize asymmetric shadow regions and their associated measurements to optimize readout time, scanning speed, dose, etc., in which case the readout center CR of the readout range LR is offset from the aperture center CA of the primary region LC(LA). This offset can be created by changing the shape (size / position) of the beam on the detector and / or by changing the size / position of the detector readout (active) region. To accommodate optimized or reduced readout range LR, Figures 5–7 show exemplary embodiments in which the readout center CR of the readout range LR is offset from the aperture center CA of the primary region LC, thereby the active (readout) shadow regions LF, LB are not equal but are sufficient for scattering fitting and estimation.

[0067] In one embodiment, Figure 5 shows an exemplary beam and detector configuration 500 having an asymmetric shadow readout region. In this embodiment, the readout range LR can be reduced, but the readout center CR is aligned with the detector center CD of the detector 502. In this embodiment, the beamformer can adjust the shape of the radiation beam incident on the detector 502 such that the aperture center CA of the primary region LC is offset from the readout center CR. The amount of offset is indicated by the axial length LO. In this configuration, the active rear shadow region LB and the active front shadow region LF are asymmetric. Here, the active rear shadow region LB is indicated by a larger axial length than the active front shadow region LF. In other embodiments, the aperture center CA can be offset in the opposite direction, in which case LF is larger than LB and has a similar effect. One or both shadow readout regions LF, LB can be used for scattering fitting.

[0068] In another embodiment, Figure 6 shows another exemplary beam and detector configuration 600 having an asymmetric shadow readout region. In this embodiment, the readout range LR can be reduced, in which case the readout center CR is offset from the detector center CD of detector 602. In this embodiment, the aperture center CA of the primary region LC is aligned with the detector center CD. The amount of offset is indicated by the axial length LO. In this configuration, the active rear shadow region LB and the active front shadow region LF are asymmetric. Here, the active rear shadow region LB is indicated by a larger axial length than the active front shadow region LF. In other embodiments, the readout center CR can be offset in the opposite direction, in which case LF is larger than LB and has a similar effect. One or both shadow readout regions LF, LB can be used for scattering fitting.

[0069] In another embodiment, Figure 7 shows another exemplary beam and detector configuration 700 having an asymmetric shadow readout region. In this embodiment, the readout range LR can be reduced, in which case both the readout center CR and aperture center CA are offset from the detector center CD of the detector 702. The net amount of offset between the readout center CR and aperture center CA is indicated by the axial length LO. In this configuration, the active rear shadow region LB and the active front shadow region LF are asymmetric. Here, the active rear shadow region LB is indicated by a larger axial length than the active front shadow region LF. In other embodiments, the readout center CR and aperture center CA can be offset in opposite directions or by opposite offsets, in which case LF is larger than LB and has a similar effect. One or both shadow readout regions LF, LB can be used for scattering fitting.

[0070] In any of these embodiments, the X-ray imaging apparatus (e.g., imaging apparatus 10) may include a data processing system (e.g., processor 40) which receives measured projection data in the primary region LC and measured scattering data in at least one shadow region LF, LB, and is configured to determine estimated scattering in the primary region LC based on the measured scattering data in at least one shadow region LF, LB. In some embodiments, the data processing system may also be configured to receive measured penumbra data in at least one penumbra region LPF, LPB, and to determine estimated scattering in the primary region LC based on the measured penumbra data in at least one penumbra region LPF, LPB.

[0071] The imaging design may include optimizing the size of the primary region LC and at least one shadow region LF, LB within the readout range LR, along with optimizing various other imaging considerations (including, for example, readout speed, scan speed, scattering estimation algorithm / protocol, and mechanical constraints), resulting in an asymmetric shadow region configuration. As described above, in various embodiments, the desired sizes of the regions LC, LF, and / or LB can be achieved, for example, using a collimator (e.g., beamformer 36) having the ability to create a variable beam width on the detector via a device that can translate and / or rotate to adjust the aperture center rCA relative to the readout center CR of the detector (e.g., X-ray detector 34). In some embodiments, the desired sizes of the regions LC, LF, and / or LB can be achieved separately or in combination with the collimator using detector readout control (e.g., sizing and positioning) via hardware and / or software.

[0072] For example, Figure 8 is a diagram of an exemplary lung phantom 804 projected onto detector 802 using an exemplary narrow collimator aperture. The central region is the lung phantom 804 exposed to the radiation beam, and the black regions on the left and right are collimator shadows 806. The black dot 808 is a lead bead directly in front of the phantom 804. In this configuration, detector 802 is shown having an aperture center CA. When the beam aperture is projected onto the detector, a primary region with axial length LA, a rear shadow region with axial length LSB, and a front shadow region with axial length LSF are created.

[0073] Figures 9 and 10 show imaging designs 900 and 1000 with data profiles along line AA crossing an exemplary lung phantom 804 in the plane of detector 802 shown in Figure 8. The horizontal axis of the data profile is the pixel position on the plane of detector 802. The vertical axis of the data profile represents the plot of measured data for each pixel along line AA. The range of the back shadow LSB on the left side of the plot indicates the range of data within the left collimator shadow region available for scattering estimation (fitting). The range of the front shadow LSF on the right side of the plot indicates the range of data within the right collimator shadow region available for scattering estimation. The potential readout range LR of detector 802 is shown along with the readout center CR. Data outside the readout range LR of detector 802 is not readout and is therefore unavailable. With a limited detector readout range, if the collimator aperture remains the same, the amount of data available for scattering fitting must be reduced.

[0074] Figure 9 shows an imaging design 900 with a data profile along line AA crossing an exemplary lung phantom 804 in the plane of detector 802 shown in Figure 8, which has a symmetrical shadow readout region. In this configuration, detector 802 is shown, with aperture center CA aligned with readout center CR. Here, the readout range LR of detector 802 is shown together with a primary region having axial length LC. The lengths of the active rear shadow region LB and the active front shadow region LF are equal and symmetric on detector 802. In this embodiment, LB and LF represent typical shadow region sizes necessary for sufficient scattering estimation.

[0075] However, as discussed above, to reduce readout time, for example, various embodiments may include a reduced readout range LR of the detector 802 and utilize an asymmetric shadow region, in which case the readout center CR of the readout range LR is offset from the aperture center CA of the primary region LC(LA). For example, Figure 10 is a diagram of imaging design 1000 having a data profile along line AA crossing an exemplary lung phantom 804 in the plane of the detector 802 shown in Figure 8, which has an asymmetric shadow readout region. Here, the readout range LR' of the detector 802 is reduced compared to the readout range LR shown in Figure 9, but the primary region axial length LC(FOV) is maintained. The axial length of the active rear shadow region LB is also maintained for scattering estimation. To correspond to the reduced readout range LR' and the same primary region LC, the active front shadow region LF' is reduced compared to the active front shadow region LF in Figure 9. As a result, the readout center CR' is offset by LO from the aperture center CA (and the readout center CR in Figure 9). In this embodiment, the lengths of the active back shadow region LB and the active front shadow region LF' are not equal (asymmetrical), but this is sufficient for scattering fitting and estimation.

[0076] In various embodiments, the offset LO between the aperture center CA and the readout center CR can be created, as described above, by changing the shape (size / position) of the beam on the detector (for example, by shifting the aperture center CA of the beam on the detector) and / or by changing the size / position of the detector readout (active) region LR.

[0077] In another example, Figure 11 shows an exemplary lung phantom 1104 projected onto detector 1102 using an exemplary collimator aperture. The central region is the lung phantom 1104 exposed to the radiation beam, and the black regions on the left and right are collimator shadows 1106. The black dot 1108 is a lead bead directly in front of the phantom 1104. In this configuration, detector 1102 is shown with its aperture center CA. Projecting the beam aperture onto the detector creates a primary region with axial length LA, a back shadow region with axial length LSB, and a forward shadow region with axial length LSF. The back shadow LSB range and forward shadow LSF range indicate the range of data within the collimator shadow available for scattering estimation.

[0078] Figures 12 and 13 illustrate symmetric and asymmetric scattering fittings, respectively, and the experimental data demonstrate the effectiveness of the disclosed asymmetric scattering fitting, applied to a data profile along line AA, which crosses an exemplary lung phantom 1104 in the plane of detector 1102 shown in Figure 11. The horizontal axis of the data profile represents the pixel position on the plane of detector 1102, and the vertical axis of the data profile represents a plot of measured data for each pixel along line AA.

[0079] Figure 12 is a data plot 1200 along line AA crossing an exemplary lung phantom 1104 in the plane of detector 1102 shown in Figure 11, which has a symmetrical shadow readout region. Here, the readout range LR of detector 1102 is shown together with a primary region having axial length LC, and the active rear shadow region LB and the active front shadow region LF are equal in length and symmetric. In this embodiment, LB and LF represent typical shadow region sizes used for sufficient scattering estimation.

[0080] Figure 13 shows a data plot 1300 along line AA crossing an exemplary lung phantom 1104 in the plane of detector 1102 shown in Figure 11, which has an asymmetric shadow readout region. Here, the readout range LR' of detector 1102 is reduced compared to the readout range LR shown in Figure 12, but the primary region axial length LC(FOV) is maintained. The axial length of the active rear shadow region LB is also maintained for scattering estimation. To correspond to the reduced readout range LR' and the same primary region LC, the active front shadow region LF' is reduced compared to the active front shadow region LF in Figure 12.

[0081] The measured data line 1210 is a line profile along line AA that crosses the irradiation area on detector 1102, which is extended into the collimator shadow LSB, LSF of the lung phantom 1104. The tail at the end of the measured data line 1210 is located within the collimator shadow LSB, LSF. The dip in the measured data line 1210 is a small shadowed region where the X-rays were blocked by the lead bead array 1108 just before the phantom 1104.

[0082] Scattered lines 1220 and 1320 are the fitted (estimated) scattering in Figures 12 and 13, respectively. The overlap between the measured data line 1210 and the scattered lines 1220 and 1320 (identified by block arrows in the figures) shows the data from collimator shadows LB and LF, LF' used for the scattering fitting. Measured data 1210 within the lead bead 1108 shadow is used as a reference for the fitted scattering (after being offset by the penetration of lead bead 1108). As shown by the experimental data in Figures 12 and 13, both scattered lines 1220 and 1320 touch the dip in the lead bead 1108 shadow in plots 1200 and 1300. This evidence supports the effectiveness of the asymmetric scattering fitting / estimate 1320 compared to the symmetric scattering fitting / estimate 1220 applied to the same measured data 1210.

[0083] In various embodiments, the offset between the aperture center and the readout center can be created, as described above, by changing the shape (size / position) of the beam on the detector (e.g., by shifting the aperture center of the beam) and / or by changing the size / position of the detector readout (active) region.

[0084] Although not shown in Figures 10 and 13, the penumbra region (which demarcates the primary region and the shadow region, for example, as shown as LPB and LPF in Figures 4-7) can be utilized in various embodiments. In asymmetric embodiments, if the two sides of the collimator have systematically different penumbras, the side with the wider shadow width may be more suitable for reducing the shadow region (for example, LF' shown in Figures 10 and 13).

[0085] In an extreme embodiment of asymmetric scattering fitting, only the collimator shadow from one side is read, and the detector region is not used to read the collimator shadow from the other side. Normally, scattering fitting does not work when there is only data from one side of the collimator shadow. In this embodiment, the imaging design performs a double scan, in which case the detector readout range is cut off at the penumbra of the collimator on one side during the first scan and at the penumbra of the collimator on the other side during the second scan. The first scan includes the collimator shadow data available from one side, and the second scan includes the collimator shadow data available from the other side.

[0086] For example, in one embodiment, the second scan may include a shift in the collimator aperture relative to the detector readout area so that the collimator shadow on the other side is read. In these embodiments, sufficient collimator shadow data is obtained by combining the collimator shadow data from one side in the first scan and the collimator shadow data from the other side in the second scan, which is available for scattering estimation. This design allows the detector readout range to be cut off in the penumbra range on one side of the collimation during each scan to maximize a useful scan FOV. By combining the available data, a reliable scattering estimation can be provided, similar to conventional collimator shadow fitting methods.

[0087] For example, Figures 14 and 15 show imaging designs 1400 and 1500 having data profiles along line AA crossing an exemplary lung phantom 804 in the plane of detector 802 shown in Figure 8. As described above, the range of the back shadow LSB on the left side of the plot indicates the range of data within the shadow region of the left collimator available for scattering estimation (fitting). The range of the front shadow LSF on the right side of the plot indicates the range of data within the shadow region of the right collimator available for scattering estimation. The reduced readout range LR of detector 802 is shown, where the readout center CR is offset by offset LO from the aperture center CA.

[0088] Figure 14 shows an imaging design 1400 having a data profile along line AA crossing an exemplary lung phantom 804 acting as the first scan of a dual scan, which has an asymmetric shadow readout region. In this design 1400, the readout range LR = LB(+LPB) + LC(+LPF), where LPB and LPF are penumbraic regions and can be used in specific embodiments as discussed below. Thus, only one shadow region LB (along with the primary region LC within the readout range LR) is read out for the scattering estimation data. Figure 15 shows an imaging design 1500 having a data profile along line AA crossing an exemplary lung phantom 804 acting as the second scan of a dual scan, which has an asymmetric shadow readout region. In this design 1500, the readout range is LR = (LPB+)LC(+LPF) + LF. Thus, only the opposite shadow region LF is read out for the scattering estimation data.

[0089] In one embodiment, the effective data acquisition area on the detector can be maximized (optimized) in a dual-scan method by shifting the collimator aperture center CA relative to the detector readout center CR of the detector readout range LR. In the first scan (for example, as shown in Figure 14), the left collimator shadow region LB overlaps with the detector readout range LR, providing left data for scattering fitting, but the detector readout range LR is aligned with the right penumbra LPF (cutoff in the right penumbra) (because this penumbra region is contaminated and at least reduces the statistical data for CT reconstruction). In the second scan (for example, as shown in Figure 15), the collimator (and its aperture center CA) is adjusted (e.g., shifted) relative to the detector and its readout range LR. The detector readout range LR is aligned with the left penumbra LPB (cutoff in the left penumbra) and overlaps with the right collimator shadow LF, providing sufficient data for scattering fitting. By combining data from the left and right shadow regions, sufficient scattering data from both the left and right of the primary region is available for accurate scattering fitting.

[0090] In this dual-design embodiment, if the first and second scans use different doses (e.g., mA), the collimator shadow data from the two scans can be scaled or weighted accordingly before or during the scattering fitting and / or reconstruction process. Furthermore, the measured projection data within the primary region can be reconstructed separately for each scan using the estimated scattering with scaling / weighting related to the dose of each scan. In some embodiments, the data from the two scans can also be reconstructed together, for example, by combining the data before or during reconstruction, while the estimated scattering is used accordingly for scattering correction.

[0091] In one embodiment, the step of determining the estimated scattering in the measured projection data includes scaling the measured scattering data in at least one shadow region based on the difference between doses during scanning. In another embodiment, the step of determining the estimated scattering in the measured projection data includes scaling the measured projection data from a first scan or a second scan based on the difference between doses during scanning.

[0092] The penumbra region associated with collimators (e.g., LPB and LPF) is typically not used in conventional CT or CBCT scanning. Typically, the penumbra region on each side of a beam collimator covers a detector range that is approximately equal to the size of the source focal point multiplied by the amplification factor. To make scattering estimations more accurate, the penumbra region of the collimator / beamformer can be excluded. In one embodiment, this can be achieved by automatically detecting the axial profile of each projection and then excluding a predetermined number of pixels in the axial direction. Another method is to perform experiments in advance for different window and scanning configurations to predefine the back and front regions for scattering measurements, taking the penumbra region into account.

[0093] However, in some embodiments, asymmetric scattering estimation techniques can estimate scattering within the penumbra region (e.g., LPB and / or LPF) and use the resulting scattering for scattering estimation within the primary region LC corresponding to the collimator aperture LA. These embodiments reduce the necessary data required within the collimator shadow region (e.g., LB and / or LF) for accurate scattering fitting / modeling, thereby enabling an increase in the effective scanning FOV (LC) for a given detector readout range LR. In one embodiment, the collimator side with a smaller shadow region readout is the side with a larger penumbra.

[0094] In this way, scattering measured within the penumbra region(s) (e.g., LPB and / or LPF) can be modeled and used as data for scattering estimation within the primary region (e.g., LC) corresponding to the collimator aperture. This reduces the amount of data required in the collimator shadow region (beyond the penumbra) for scattering fitting, allowing more of the area within the detector readout range LR to be used for the primary region LC (FOV of patient scanning data).

[0095] For example, if the penumbra in the air can be accurately measured and mapped (Pmap), the scattering within the penumbra can be estimated. In one embodiment, the first reconstruction of the image is performed without scattering correction. An estimated projection onto the penumbra is calculated (Pp), and an estimated projection into the aperture of pixels adjacent to the penumbra (Po) is also calculated. The measured projection data of pixels adjacent to the penumbra into the aperture (PoM) is scaled and modulated by the penumbra map (PM) to estimate the following values, which are the modulated primary value within the penumbra (P_primary) and the scattering within PoM (Po_scatter), in the equation:

number

[0096] Here,

number

number

[0097] Assuming that the scattering within the penumbra region and the pixels adjacent to the penumbra within the aperture are the same, the relationship between the scattering within the penumbra, the measured penumbra value, and the value of the pixels adjacent to the penumbra within the collimator aperture is as follows:

number

[0098] When using simple pixel-level multiplication for penumbraic modulation, the scattering within the penumbra is as follows:

number

[0099] In one embodiment, an iterative method can be applied to improve the accuracy of the above technique. For example, the above process can be performed after a first scattering correction using scattering fitted from scattering measured in the collimator shadow and scattering estimated from the penumbra. This can result in a more accurate estimation of scattering in the penumbra, and consequently, enable a more accurate scattering estimation.

[0100] In another embodiment, a scattering fit using scattering obtained within the penumbra may have different weightings for data from collimator shadows and data from the penumbra.

[0101] Various techniques and methods can utilize different scanning shapes, detector positioning, and / or beamformer window shapes. In some embodiments, the detector may also be offset laterally.

[0102] The following flowcharts and block diagrams illustrate exemplary configurations and methods related to scattering estimation by the system described above. The exemplary methodology can be implemented in logic, software, hardware, or a combination thereof. In addition, while the procedures and methods are presented in a certain order, the blocks may be executed in different orders, including serial and / or parallel. Therefore, the following steps, including imaging, image-based pre-delivery steps, and therapeutic delivery, are shown sequentially, but may be executed simultaneously, including in real time. Furthermore, additional or fewer steps may be used.

[0103] Figure 16 is a flowchart illustrating an exemplary method 1600 of scattering estimation and correction using an asymmetric scanning design as described above. The input may include any optional prior data and / or scanning design. In this embodiment, step 1610 includes data acquisition. For example, during rotation of a radiation source projecting a collimated radiation beam toward a target and a radiation detector, the method measures projection data (primary + scattering) in the central (primary) region of the radiation detector and measures scattering using the forward shadow peripheral region and / or backward shadow peripheral region of the detector. In these embodiments, according to any of the embodiments described above, the aperture center of the primary region is offset from the readout center of the readout range during scanning, thereby making the forward and backward shadow regions asymmetric (including when only one shadow region is used).

[0104] The data acquisition in step 1610 may also include adjusting the shape / position of the radiation beam using a beamformer before and / or during scanning. The step of adjusting the radiation beam with a beamformer may include rotating and translating the highly X-ray attenuated material of the beamformer during scanning to block radiation from directly exposing shadow regions. Step 1610 may also include adjusting the readout range (including shifting the active region). Adjustment of the radiation beam and / or readout range can be used to create asymmetrical shadow regions by offsetting the aperture center of the primary region and the readout center of the X-ray detector.

[0105] Next, step 1620 includes scattering estimation. For example, according to any of the embodiments described above, the method estimates scattering in the projection data from the central (primary) region using scattering measurements from shadow regions and / or penumbra regions. Next, step 1630 includes scattering correction. For example, scattering estimated from step 1620 is subtracted from the projection data to obtain scattering-corrected projection data. The output includes scattering-corrected projection data suitable for imaging. Various embodiments can utilize different scanning shapes, detector positioning / active regions, beamformer positioning / window shapes, etc.

[0106] Figure 17 is a flowchart illustrating an exemplary method 1700 of scattering estimation and correction using an asymmetric scanning design having first and second scans, such as those described above. The input may include any optional prior data and / or scanning design. In this embodiment, step 1710 includes data acquisition during the first scan, in which case the method measures projection data in the central (primary) region of the radiation detector and measures scattering in the first shadow region of the detector. Next, in step 1720, the method adjusts the position of the radiation beam between the first scan and the second scan. For example, step 1720 may adjust the beam so that the first shadow region overlaps with the first side of the detector readout range during the first scan and the second shadow region overlaps with the second side of the readout range during the second scan. Next, step 1730 includes data acquisition during the second scan, in which the method measures projection data in the central (primary) region of the radiation detector and measures scattering in the second shadow region of the detector. Next, in step 1740, the method may combine measured scattering data from the first and second shadow regions, including the use of various model fitting techniques. In some embodiments, step 1740 may be skipped or combined with step 1750.

[0107] Next, step 1750 includes scattering estimation, in which case the method estimates the scattering in the projection data from the central (primary) region using scattering measurements from the first and second shadow regions. Next, step 1760 includes scattering correction, in which the method subtracts the estimated scattering from the projection data to obtain scattering-corrected projection data. The output includes scattering-corrected projection data suitable for imaging. Similar to the steps of method 1600, the steps of method 1700 can be carried out according to any of the embodiments described above.

[0108] One or more optimization processes are also applicable to all of the embodiments described above to determine beam positioning, determine readout range, estimate scattering, etc. For example, in one embodiment, Figure 18 is a flowchart illustrating an exemplary method 1800 for optimizing an asymmetric scanning design such as those described above. One constraint and / or goal during optimization may be a target or reduced readout time. As discussed above, readout time can be reduced by reducing the detector readout range (including the primary shadow region and the readout shadow region) to enable scanning at higher frame rates. However, when a reduced detector readout range is used and scattering estimation using collimator shadow data fitting is applied, it may be necessary to allocate a minimum or target readout range to read out data in the collimator shadow region. Total scan time, treatment workflow, and / or throughput may be additional factors. Step 1810 includes determining beam positioning. Step 1820 includes determining the detector readout range. In some embodiments, steps 1810 or 1820 may be optional, limiting the optimization to other variables. In other embodiments, steps 1810 and 1820 may be performed in a specific order, simultaneously, and / or iteratively. For example, one step may be performed to arrive at an initial optimized design, including being iterative in optimizing the design, and then other steps may be performed considering others. Then, in step 1830, the scanning design may be carried out as described above.

[0109] Figure 19 is a flowchart illustrating an exemplary method 1900 of IGRT using a radiotherapy device (including imaging device 10, etc.). Patient pre-image data 1905 may be used, which may be pre-acquired planning images including pre-CT images. Pre-image data 1905 may also include treatment plans, phantom information, models, prior information, etc. In some embodiments, pre-image data 1905 is generated by the same radiotherapy device, but at an earlier point in time. In step 1910, patient imaging is performed using a low-energy radiation source (e.g., kV radiation from X-ray source 30). In one embodiment, imaging includes helical scanning with a fan or cone-beam geometric shape. Step 1910 can generate high-quality (HQ) images or imaging data 1915 using the scattering estimation and correction techniques described above. In some embodiments, image quality can be tuned to optimize the balance between image quality / resolution and dose. In other words, not all images need to be of the highest quality, or image quality can be tuned to optimize or trade off the balance between image quality / resolution and image acquisition time. The imaging step 1910 may also include image processing to generate a patient image based on the imaging data (for example, according to the methods described above). Although the image processing step 1920 is shown as part of the imaging step 1910, in some embodiments the image processing step 1920 is a separate step, including cases where the image processing is performed by a separate device.

[0110] Next, in step 1930, one or more image-based pre-delivery steps, which will be discussed later, are performed, at least in part, based on the imaging data 1915 from step 1910. As will be discussed in more detail below, step 1930 may include determining various parameters related to the therapeutic procedure and the (subsequent) imaging plan. In some embodiments, the image-based pre-delivery step (1930) may require more imaging (1910) before therapeutic delivery (1940). Step 1930 may include adapting the treatment plan based on the imaging data 1915 as part of an adaptive radiotherapy routine. In some embodiments, the image-based pre-delivery step 1930 may include real-time treatment planning. Embodiments may also include simultaneous, overlapping, and / or alternating activation of the imaging source and the therapeutic source. Real-time treatment planning may involve any or all of these types of imaging and therapeutic radiation activation techniques (simultaneous, overlapping, and / or alternating).

[0111] Next, in step 1940, therapeutic treatment delivery is performed using a high-energy radiation source (e.g., MV radiation from therapeutic radiation source 20). Step 1940 delivers the therapeutic dose 1945 to the patient according to the treatment plan. In some embodiments, the IGRT method 1900 may include returning to step 1910 for additional imaging at various intervals, followed by image-based pre-delivery steps (1930) and / or therapeutic delivery (1940) as needed. In this way, high-quality imaging data 1915 may be generated and utilized during IGRT using one adaptive therapy-capable device 10. As described above, steps 1910, 1920, 1930, and / or 1940 may be performed simultaneously, overlapping, and / or alternately.

[0112] IGRT can have at least two overarching objectives: (i) to deliver a highly conformal dose distribution to the target volume, and (ii) to deliver the therapeutic beam with high precision across all therapeutic fractions. A third objective may be to achieve the two overarching objectives while minimizing the time per fraction. Accurate delivery of the therapeutic beam requires the ability to identify and / or track the location of intrafractions in the target volume using high-quality imaging. The ability to increase the delivery rate requires the ability to move the radiation source accurately, precisely, and rapidly according to the treatment plan.

[0113] Figure 20 is a block diagram 2000 showing an exemplary image-based pre-delivery step / option that may be associated with step 1930 above. It will be understood that the imaging device 10 described above (e.g., as part of a radiotherapy device) can generate kV images that can be used in various ways, including image-based pre-delivery steps (1930), without departing from the scope of the invention. For example, the image 1915 generated by the radiotherapy device can be used to position the patient pre-treatment (2010). Patient positioning may include correlating or positioning the current imaging data 1915 with previous pre-treatment scans and / or imaging data associated with the plan, including the treatment plan. Patient positioning may also include feedback on the patient's physical position relative to the radiation source to verify whether the patient is physically within range of the delivery system. The patient can be adjusted accordingly, if necessary. In some embodiments, the patient positioning imaging may be intentionally of low quality to provide adequate positioning information while minimizing the dose.

[0114] Images generated by the imaging device 10 can also be used for treatment planning or replanning (2020). In various embodiments, step 2020 may include reviewing the treatment plan, modifying the treatment plan, generating a new treatment plan, and / or selecting a treatment plan from a set of treatment plans (sometimes called "same-day plans"). For example, if the imaging data 1915 shows that the target volume or ROI is the same as when the treatment plan was formulated, the treatment plan can be reviewed. However, if the target volume or ROI is not the same, replanning of the therapeutic procedure may be necessary. In the case of replanning, the imaging data 1915 (generated by the X-ray imaging device 10 in step 1910) is of high quality, so the imaging data 1915 can be used for treatment planning or replanning (e.g., generating a new or modified treatment plan). Thus, pre-treatment CT imaging via different devices is not required. In some embodiments, review and / or replanning may be ongoing procedures before and / or after various treatments.

[0115] According to another exemplary use case, the imaging dose (2030) can be calculated using the images generated by the imaging device 10, and this imaging dose can be used for the ongoing determination of the total dose to the patient and / or for subsequent imaging planning. The quality of subsequent imaging can also be determined as part of the treatment plan, for example, to balance quality and dose. According to another exemplary use case, the therapeutic dose (2040) can be calculated using the images generated by the imaging device 10, and this therapeutic dose can be used for the ongoing determination of the total dose to the patient and / or can be included as part of the treatment plan or replanning.

[0116] According to another exemplary use case, images generated by the imaging device 10 can be used, for example, as part of adaptive therapy and / or treatment plan generation, in connection with planning or adjusting parameters or plans for other imaging (2050) and / or other treatments (2060). According to another exemplary use case, images generated by the imaging device 10 can be used in connection with adaptive therapy monitoring (2070), which may include monitoring of treatment delivery and adaptations as needed.

[0117] It should be understood that the image-based pre-delivery steps (1930) are not mutually exclusive. For example, in various embodiments, calculating the therapeutic dose (2040) can be a step in itself and / or part of adaptive therapy monitoring (2070) and / or treatment planning (2020). In various embodiments, the image-based pre-delivery steps (1930) can be performed automatically and / or manually with human involvement.

[0118] The devices and methods described above, including adjustable collimation of image radiation and scattering estimation and correction schemes, improve scattering estimation and consequently produce higher quality kV-generated images than conventional intra-treatment imaging systems such as CBCT.

[0119] Figure 21 is a block diagram 2100 showing exemplary data sources that may be used during imaging (1910) and / or subsequent image-based pre-delivery steps (1930). Detector data 2110 represents all data received by the image radiation detector 34. Projection data 2120 is data generated by radiation incident within a collimated beam region, referred above as the primary or central region. Penumbra data 2130 is data generated by radiation incident within the penumbra region. Scatter data 2140 is data generated by radiation incident within the peripheral region outside the penumbra region, referred above as the shadow region(s).

[0120] In one embodiment, penumbra data 2130 can be used to separate or identify projection and / or scattering data. As described in detail above, scattering data 2140 can be used to estimate scattered radiation within projection data 2120. In another embodiment, scattering data 2140 can be used to determine the residual effect of scattering from a therapeutic radiation source 20 (e.g., MV) when two sources 20, 30 are operated simultaneously or interleaved.

[0121] In this way, the penumbra data 2130 and / or scattered data 2140 can be used to improve the quality of the image generated by the imaging step 1910. In some embodiments, the penumbra data 2130 and / or scattered data 2140 can be combined with projection data 2120 and / or analyzed taking into account applicable imaging settings 2150, treatment settings 2160 (e.g., simultaneous imaging and treatment radiation), and any other data 2170 related to the imaging device 10 at the time of data acquisition at the imaging detector 34. In other embodiments, the data may be used in the treatment planning step 1930.

[0122] While the disclosed technology has been shown and described in relation to specific aspects, embodiments, or multiple embodiments, it will be apparent to those skilled in the art that equivalent changes and modifications will be conceivable upon reading and understanding this specification and the accompanying drawings. In particular, with respect to the various functions performed by the elements described above (such as components, assemblies, devices, members, compositions, etc.), the terms used to describe such elements (including being called “means”) are intended to correspond to any element that performs a specified function of the element described, even if it is not structurally equivalent to a disclosed structure that performs the function in the exemplary aspects, embodiments, or multiple embodiments of the disclosed technology described herein, unless otherwise indicated. In addition, while certain features of the disclosed technology may be described above in relation to only one or more of several exemplary aspects or embodiments, such features can be combined with one or more other features of other embodiments so as may be desirable and advantageous for any given or particular application.

[0123] The embodiments discussed herein relate to the systems and methods described above, but these embodiments are intended to be illustrative and not to limit the application of these embodiments to the discussions set forth herein. While the present invention has been illustrated by the description of its embodiments, and embodiments have been described in some detail, it is not the applicant's intention to limit the appended claims to such detail, or to limit them in any way. Further advantages and modifications will be readily apparent to those skilled in the art. Therefore, the present invention in broader embodiments is not limited to the specific details illustrated and described, representative apparatus and methods, and exemplary examples. Thus, deviations from such details can be made without departing from the spirit or scope of the applicant's general inventive concept.

Claims

1. A method for estimating scattering in an X-ray image, A step of receiving measured projection data from the primary region of an X-ray detector, wherein the primary region of the X-ray detector is directly exposed to a radiation beam from a radiation source during at least one scan; The steps include receiving measured scattering data from at least one shadow region of the X-ray detector, wherein the at least one shadow region of the X-ray detector is blocked from direct exposure to the radiation beam, The steps include determining the estimated scattering in the measured projection data based on the measured scattering data in the at least one shadow region, The aperture center of the primary region is offset from the read center of the read range during the at least one scan. method.

2. The method according to claim 1, further comprising the step of adjusting the position of the radiation beam such that the aperture center of the primary region is offset from the readout center of the X-ray detector.

3. The at least one scan includes a first scan and a second scan, and the at least one shadow region includes a first shadow region and a second shadow region, and the method is The reading range has a first side and a second side, the first side being located on the opposite side of the second side. Steps to adjust the position of the radiation beam during the period after the first scan and before the second scan such that the first shadow region overlaps with the first side of the readout range during the first scan, and the second shadow region overlaps with the second side of the readout range during the second scan. It further includes, The step of determining the estimated scattering in the measured projection data is based on the measured scattering data in the first shadow region and the second shadow region. The method according to claim 1.

4. The method according to claim 3, wherein the second side of the readout range is aligned with the first penumbra region opposite to the first shadow region during the first scan, and the first side of the readout range is aligned with the second penumbra region opposite to the second shadow region during the second scan.

5. The method according to claim 3, wherein a first dose of radiation is irradiated in the first scan, and a second dose of radiation different from the first dose is irradiated in the second scan.

6. The method according to claim 5, wherein the step of determining the estimated scattering in the measured projection data includes scaling the measured scattering data in at least one of the first shadow region or the second shadow region based on the difference between the first radiation dose and the second radiation dose.

7. The method according to claim 5, wherein the step of determining the estimated scattering in the measured projection data includes scaling the measured projection data from at least one of the first scan or the second scan based on the difference between the first radiation dose and the second radiation dose.

8. The method according to claim 3, wherein the step of determining the estimated scattering in the measured projection data includes combining and reconstructing the measured projection data from the first scan and the second scan together.

9. The steps include receiving measured penumbra data within at least one penumbra region, A step of determining the estimated scattering in the primary region based on the measured penumbra data in the at least one penumbra region. The method according to claim 1, further comprising:

10. The method according to claim 9, wherein the step of determining the estimated scattering in the primary region based on the measured penumbra data in the at least one penumbra region includes determining the estimated scattering in a primary region pixel adjacent to a penumbra region pixel.

11. The method according to claim 10, wherein determining the estimated scattering in the primary region based on the measured penumbra data in the at least one penumbra region is an iterative process.

12. The method according to claim 9, wherein the step of determining the estimated scattering in the primary region includes weighting the measured scattering data in the at least one shadow region differently from the measured penumbra data in the at least one penumbra region.

13. A radiotherapy delivery device, A rotatable gantry system positioned at least partially around the patient support, A first radiation source coupled to the rotatable gantry system, configured as a therapeutic radiation source, A second radiation source coupled to the rotatable gantry system, configured as an imaging radiation source having a lower energy level than the therapeutic radiation source, A radiation detector coupled to the rotatable gantry system and positioned to receive radiation from the second radiation source, A beamformer configured to adjust the shape of a radiation beam emitted by the second radiation source, wherein the primary region of the radiation detector is directly exposed to the radiation beam, and at least one shadow region of the radiation detector is blocked by the beamformer from direct exposure to the radiation beam. A data processing system, It is configured to receive measured projection data within the primary region and measured scattering data within the at least one shadow region, The system is configured to determine the estimated scattering in the primary region based on the measured scattering data in the at least one shadow region, wherein the aperture center of the primary region is offset from the read center of the read range. The system is configured to reconstruct patient images based on the estimated scattering, A data processing system configured to deliver a dose of therapeutic radiation to the patient via the first radiation source based on the patient image during adaptive IGRT, and A radiotherapy delivery device equipped with the following features.

Images