Method for producing monobrominated aniline compounds

The method of brominating aniline compounds using a brominating agent formed from bromine and a halogenated salt in an aqueous solvent system addresses the challenge of dibromo by-product formation, enabling efficient production of monobrominated anilines for pharmaceuticals and electronics.

JP7884820B2Active Publication Date: 2026-07-06MANAC
View PDF 2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
MANAC
Filing Date
2021-12-24
Publication Date
2026-07-06

AI Technical Summary

Technical Problem

Conventional methods for producing monobrominated aniline compounds face challenges in selectively yielding 2-bromo or 4-bromo products while suppressing the formation of dibromo by-products, which are difficult to remove, leading to low industrial productivity and inefficiency.

Method used

A method involving the reaction of bromine with a halogenated salt in an aqueous solution and an organic solvent to create a brominating agent, which is then used to brominate an aniline compound with a protected amino group, thereby suppressing dibromo formation and enhancing selectivity.

Benefits of technology

This method allows for the efficient production of monobrominated aniline compounds, useful in pharmaceuticals and electronic materials, by minimizing dibromo by-products and improving productivity through controlled bromination.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 0007884820000001
    Figure 0007884820000001
  • Figure 0007884820000002
    Figure 0007884820000002
  • Figure 0007884820000003
    Figure 0007884820000003
Patent Text Reader

Abstract

To provide a method for producing monobromoaniline, which is extremely useful as an intermediate in manufacture of pharmaceuticals, electronic materials and various functional chemicals.SOLUTION: In a method for producing a compound represented by formula (2), a brominating agent obtained by reacting a halide salt with bromine in water and an organic solvent is reacted with the compound represented by formula (1). (In the formulas, PG is a protective group; each R is independently H, a C1-6 alkyl group, or the like.)SELECTED DRAWING: None
Need to check novelty before this filing date? Find Prior Art