Oral cavity aerosol agent

Abstract

The present invention relates to an oral cavity aerosol agent that exhibits high foaming performance and can favorably protect the gums. That is to say, the present invention is an oral cavity aerosol agent containing a stock solution (X) and a propellant (Y). The stock solution (X) contains the following components (a), (b), and (c): (a) a C12-22 monohydric alcohol in an amount of 0.6 mass% to 10 mass%, (b) a surfactant, and (c) water. The mass ratio ((b) / (a)) of the component (b) content to the component (a) content in the stock solution (X) is from 0.08 to 10, and the ethanol content is 8 mass% or less.

Description

Oral aerosol

[0001] The present invention relates to an oral aerosol.

[0002] Oral compositions are available in a variety of dosage forms, including paste and liquid, and products that take advantage of the characteristics of each dosage form have been put into practical use. Meanwhile, oral aerosols, in which oral compositions are filled into aerosol containers together with a propellant such as carbon dioxide (carbon dioxide gas) and sprayed upon use, are being developed because they can take advantage of the blood flow promoting effect of carbon dioxide.

[0003] For example, Patent Document 1 discloses a foam-like agent for preventing and improving gingival recession, which contains a concentrate containing medicinal ingredients such as tocopherol acetate and glycyrrhetinic acid, and a propellant containing carbon dioxide, and aims to prevent or improve gingival recession by applying the medicinal ingredients together with carbon dioxide to the gums. Patent Document 2 also discloses an oral aerosol agent which contains a concentrate and a propellant containing carbon dioxide, the concentrate containing a liquid dihydric alcohol, medicinal ingredients, a nonionic surfactant, and water in predetermined amounts and mass ratios, and attempts to enjoy the benefits of the medicinal ingredients while maintaining gingival health through the blood flow promoting effect of carbon dioxide.

[0004] (Patent Document 1) JP 2017-95382 A (Patent Document 2) JP 2018-104320 A

[0005] The present invention provides an oral aerosol comprising a concentrate (X) and a propellant (Y), wherein the concentrate (X) contains the following components (a), (b), and (c): (a) 0.6% by mass to 10% by mass of a monohydric alcohol having from 12 to 22 carbon atoms, (b) a surfactant, and (c) water, wherein the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the concentrate (X) is from 0.08 to 10, and the ethanol content is 8% by mass or less.

[0006] In neither of the above Patent Documents 1 and 2 has it been possible to sufficiently improve foam performance such as foam retention and foam feel of the sprayed foam, and there is still room for improvement.

[0007] That is, the present invention relates to an oral aerosol that can exhibit high foaming properties and provide good gum protection.

[0008] The present inventors have conducted extensive research and have found that, in an oral aerosol comprising a concentrate and a propellant containing carbon dioxide, by using a concentrate containing a specific amount of a specific monohydric alcohol, as well as a nonionic surfactant and water, and with a limited amount of ethanol, it is possible to obtain an oral aerosol that thickens the sprayed foam, improves foam retention and the feeling of coating the gums after rinsing, thereby providing good gum protection and providing an excellent usability.

[0009] The oral aerosol of the present invention can spray dense foam and exhibit high foam retention. Furthermore, even after application to the oral cavity and rinsing, the foam spreads widely throughout the oral cavity and adheres well to the gums, providing a feeling that the gums are protected by a smooth film and an excellent feeling that the gums are coated.

[0010] 1 is a photograph taken with a digital camera of foam sprayed with the agent of Example 1. FIG. 2 is a photograph taken with a digital camera of foam sprayed with the agent of Comparative Example 1. Detailed Description of the Invention

[0011] The present invention will be described in detail below. The oral aerosol of the present invention is prepared by filling a concentrate (X) and a propellant (Y) into an aerosol container and spraying the concentrate (X) into the oral cavity at the time of use. When carbon dioxide is contained in the propellant (Y), a portion of the carbon dioxide is dissolved in the concentrate (X) and is also present in the foam formed by the concentrate (X) after spraying from the aerosol container. This allows carbon dioxide to be efficiently delivered into the oral cavity while maintaining excellent foaming properties even after application to the oral cavity and rinsing.

[0012] The foam formed by spraying from the oral aerosol of the present invention provides, from spraying to rinsing, "a soft and chewy foam feeling," "spreads widely in the oral cavity while adhering well to the gums," and "provides the feeling that the gums are protected by a smooth film," which are generally referred to as "excellent foam performance."

[0013] The concentrate (X) contained in the oral aerosol of the present invention contains, as component (a), 0.6% by mass to 10% by mass of a monohydric alcohol having from 12 to 22 carbon atoms. The inclusion of such component (a) enables the formation of an α-gel having a lamellar structure together with component (b) in the presence of component (c) described below, and enables the formation of foam that exhibits excellent foam performance from spraying through to rinsing.

[0014] Component (a) is preferably one or more selected from cetanol, stearyl alcohol, lauryl alcohol, myristyl alcohol, and behenyl alcohol, more preferably one or two selected from cetanol and stearyl alcohol, and even more preferably contains both cetanol and stearyl alcohol as component (a). From the viewpoint of ensuring excellent foaming performance and enhancing the feeling of coating on the gums, component (a) preferably contains at least stearyl alcohol. The content of stearyl alcohol in the concentrate (X) is preferably 0.6% by mass or more, more preferably 0.65% by mass or more, even more preferably 0.7% by mass or more, preferably 10% by mass or less, more preferably 7% by mass or less, even more preferably 4% by mass or less, and even more preferably 1.5% by mass or less.

[0015] From the viewpoint of ensuring the expression of excellent foam performance, the content of component (a) in the concentrate (X) is 0.6% by mass or more, preferably 0.8% by mass or more, more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, and 10% by mass or less, preferably 8% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. The content of component (a) in the concentrate (X) is 0.6% by mass or more and 10% by mass or less, preferably 0.8 to 8% by mass, more preferably 1.5 to 5% by mass, and even more preferably 1.8 to 3% by mass.

[0016] The concentrate (X) contained in the oral aerosol of the present invention contains a surfactant as component (b). The inclusion of component (b), together with component (a), ensures the development of excellent foaming properties from spraying through to rinsing.

[0017] The surfactant of component (b) used in the present invention is preferably one or more selected from nonionic surfactants, anionic surfactants, and amphoteric surfactants.

[0018] The nonionic surfactant is preferably an ester-type nonionic surfactant, specifically, one or more selected from sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, higher fatty acid glycerin esters, polyoxyethylene glyceryl mono-fatty acid esters, and sucrose fatty acid esters. Among them, from the viewpoint of providing the raw solution (X) with better emulsion stability, one or more selected from sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters are preferred, and it is more preferred to use sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters in combination.

[0019] The sorbitan fatty acid ester is preferably derived from a fatty acid having 10 or more carbon atoms, more preferably from a fatty acid having 12 or more carbon atoms, more preferably from a fatty acid having 20 or less carbon atoms, and more preferably from a fatty acid having 18 or less carbon atoms. Specific examples include one or more selected from sorbitan monocaprate, sorbitan monoundecylate, sorbitan monolaurate, sorbitan monotridecylate, sorbitan monomyristate, sorbitan monopalmitate, sorbitan monooleate, sorbitan trioleate, sorbitan tetraoleate, sorbitan sesquioleate, sorbitan monostearate, and sorbitan tristearate. Of these, one or more selected from sorbitan monooleate, sorbitan sesquioleate, and sorbitan monostearate are preferred, with sorbitan monostearate being more preferred.

[0020] The polyoxyethylene sorbitan fatty acid ester is preferably derived from a fatty acid having 6 or more carbon atoms, more preferably from a fatty acid having 12 or more carbon atoms, more preferably from a fatty acid having 22 or fewer carbon atoms, and even more preferably from a fatty acid having 20 or fewer carbon atoms. The average number of moles of ethoxy groups added in the polyoxyethylene sorbitan fatty acid ester is preferably 5 to 40 moles, more preferably 10 to 25 moles, and even more preferably 15 to 25 moles. Specific examples include one or more selected from polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monomyristate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, and polyoxyethylene sorbitan monooleate. Of these, one or more selected from polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, and polyoxyethylene sorbitan monooleate are preferred, with polyoxyethylene sorbitan monostearate being even more preferred.

[0021] The anionic surfactant preferably has as its lipophilic group a saturated or unsaturated hydrocarbon group having 8 to 18 carbon atoms, the hydrocarbon group having a straight or branched chain. The hydrocarbon group more preferably has 12 to 16 carbon atoms. The hydrophilic group is preferably a carboxylic acid, a sulfonic acid, a phosphoric acid, or a salt thereof. Specific examples include one or more selected from alkyl sulfate ester salts, polyoxyethylene alkyl ether sulfate ester salts, alkyl sulfosuccinate salts, polyoxyethylene alkyl ether sulfosuccinate salts, alkyl ether carboxylate salts, alkyl phosphate salts, polyoxyethylene alkyl ether phosphate salts, fatty acid monoglyceride sulfate salts, alkyl sulfoacetate salts, and olefin sulfonate salts. The salt is preferably an alkali metal salt or alkaline earth metal salt, such as sodium salt, potassium salt, or magnesium salt, with sodium salt being particularly preferred.

[0022] Specific examples of amphoteric surfactants include one or more selected from acetate betaines such as lauryl dimethylamino acetate betaine; imidazolinium betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amido alkyl betaines such as coconut oil fatty acid amidopropyl betaine; and long-chain alkyl imidazoline betaine salts such as N-alkyl-1-hydroxyethyl imidazoline betaine sodium.

[0023] As component (b), a nonionic surfactant is preferred from the viewpoint of ensuring the development of excellent foaming properties from spraying through to rinsing.

[0024] From the viewpoint of ensuring the expression of excellent foam performance, the content of component (b) in the concentrate (X) is preferably 0.03% by mass or more, more preferably 0.08% by mass or more, even more preferably 0.15% by mass or more, still more preferably 0.3% by mass or more, still more preferably 0.5% by mass or more, preferably 15% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, and still more preferably 1.8% by mass or less. The content of component (b) in the concentrate (X) is preferably 0.03% by mass or more and 15% by mass or less, more preferably 0.08 to 5% by mass, even more preferably 0.15 to 5% by mass, still more preferably 0.3 to 3% by mass, and even more preferably 0.5 to 1.8% by mass.

[0025] When component (b) is a nonionic surfactant, its content in stock solution (X) is preferably 0.03 mass% or more, more preferably 0.08 mass% or more, even more preferably 0.15 mass% or more, even more preferably 0.3 mass% or more, even more preferably 0.5 mass% or more, preferably 15 mass% or less, more preferably 5 mass% or less, even more preferably 3 mass% or less, even more preferably 1.8 mass% or less.When component (b) is an anionic surfactant, its content in stock solution (X) is preferably 0.4 mass% or less, more preferably 0.1 mass% or less, even more preferably 0.01 mass% or less.It is preferable that component (b) does not contain anionic surfactant. When component (b) is an amphoteric surfactant, its content in the concentrate (X) is preferably 0.03% by mass or more, more preferably 0.15% by mass or more, even more preferably 0.3% by mass or more, and preferably 15% by mass or less, more preferably 3% by mass or less, and even more preferably 1% by mass or less.

[0026] From the viewpoint of ensuring the stability of the stock solution (X), the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the stock solution (X) is 0.08 or more, preferably 0.1 or more, more preferably 0.14 or more, even more preferably 0.23 or more, still more preferably 0.3 or more and 10 or less, preferably 7 or less, more preferably 3 or less, even more preferably 2 or less, still more preferably 1.5 or less, and even more preferably 0.8 or less. The mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the stock solution (X) is 0.08 or more and 10 or less, preferably 0.1 to 7, more preferably 0.14 to 3, even more preferably 0.14 to 2, still more preferably 0.23 to 1.5, and even more preferably 0.3 to 0.8.

[0027] The concentrate (X) contained in the oral aerosol of the present invention contains water as component (c). In the present invention, the water of component (c) refers to the total water contained in the concentrate (X), including not only the purified water and the like contained in the concentrate (X) but also the water contained in each of the components contained therein. By including water as component (c), it is possible to ensure that the concentrate (X) has an appropriate viscosity and good shape retention, while favorably dispersing or dissolving each component and ensuring the expression of excellent foam performance.

[0028] The content of component (c) in the stock solution (X) is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 71% by mass or more, still more preferably 74% by mass or more, preferably 98% by mass or less, more preferably 95% by mass or less, even more preferably 85% by mass or less, and still more preferably 80% by mass or less. The content of component (c) in the stock solution (X) is preferably 50% by mass or more and 98% by mass or less, more preferably 60 to 95% by mass, even more preferably 71 to 85% by mass, and still more preferably 74 to 80% by mass.

[0029] The concentrate (X) contained in the oral aerosol of the present invention has an ethanol content of 8% by mass or less. By limiting the ethanol content in the concentrate (X), it is possible to effectively prevent the foam from defoaming or breaking after spraying, and also to suppress the occurrence of unnecessary irritation. The ethanol content in the concentrate (X) is 8% by mass or less, preferably 6% by mass or less, more preferably 4% by mass or less, even more preferably 2% by mass or less, and even more preferably 0.4% by mass or less, or it is preferable that the concentrate (X) does not contain ethanol.

[0030] When the concentrate (X) contained in the oral aerosol of the present invention contains a binder, it is preferable to appropriately limit its content. By avoiding an excessive binder content in the concentrate (X), the storage stability of the agent can be ensured while maintaining an appropriate viscosity, and unnecessary clogging that would hinder spraying can be effectively prevented. Specific examples of such binders include sodium carboxymethylcellulose, hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, hydroxypropylmethylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and methoxyethylene maleic anhydride copolymer.

[0031] From the viewpoint of effectively preventing unnecessary clogging while maintaining a suitable viscosity, the content of the binder in the raw solution (X) is preferably 1% by mass or less, more preferably 0.8% by mass or less, even more preferably 0.6% by mass or less, and still more preferably 0.05% by mass or less. Alternatively, the raw solution (X) may not contain a binder.

[0032] The concentrate (X) contained in the oral aerosol of the present invention may contain one or more polyols (d) selected from glycerin, propylene glycol, ethylene glycol, sorbitol, xylitol, erythritol, reduced palatinose, and mannitol. Among these, the component (d) is preferably one or more selected from glycerin, sorbitol, xylitol, erythritol, reduced palatinose, and mannitol, and more preferably one or more selected from glycerin, sorbitol, xylitol, and erythritol.

[0033] The content of component (d) in the stock solution (X) is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 18% by mass or less, and still more preferably 8% by mass or less. Alternatively, the stock solution (X) may not contain component (d).

[0034] The concentrate (X) contained in the oral aerosol of the present invention may contain, in addition to the above-mentioned components, pH adjusters, preservatives, medicinal ingredients, fragrances, pigments, etc., within the range that does not impair the effects of the present invention.

[0035] From the viewpoint of exhibiting excellent foam performance unaffected by temperature changes and from the viewpoint of enabling the concentrate (X) to be sprayed well from an aerosol container, the viscosity of the concentrate (X) at 25°C is preferably 500 mPa·s or more, more preferably 700 mPa·s or more, even more preferably 1000 mPa·s or more, still more preferably 1300 mPa·s or more, still more preferably 1800 mPa·s or more, preferably 8000 mPa·s or less, more preferably 6000 mPa·s or less, still more preferably 5000 mPa·s or less, and still more preferably 4000 mPa·s or less. Here, the viscosity of the concentrate (X) can be measured using a BM-type viscometer (manufactured by Toki Sangyo Co., Ltd.).

[0036] The propellant (Y) contained in the oral aerosol of the present invention preferably contains carbon dioxide. Carbon dioxide can contribute to the development of high foam retention while facilitating the spraying of dense foam. From the viewpoint of ensuring the development of excellent foam performance, the carbon dioxide content in the propellant (Y) is preferably 51% by mass or more, more preferably 80% by mass or more, even more preferably 90% by mass or more, even more preferably 95% by mass or more, and preferably 100% by mass or less, more preferably 100% by mass. Note that the carbon dioxide content refers to the content in the propellant (Y) before a portion of the carbon dioxide may be dissolved in the concentrate (X) during storage, i.e., before the concentrate (X) and the propellant (Y) are mixed, or before they are filled into an aerosol container.

[0037] In addition to the carbon dioxide, the propellant (Y) may contain one or more gases selected from nitrogen; liquefied petroleum gases such as isobutane, normal butane, and mixtures thereof; and liquefied gases such as dimethyl ether and isopentane, and may be used as a mixed gas with carbon dioxide.

[0038] In the oral aerosol of the present invention, from the viewpoint of ensuring the expression of excellent foam performance, the mass ratio of the concentrate (X) to the propellant (Y) ((X):(Y)) is preferably 95:5 to 99:1, more preferably 97:3 to 98.5:1.5.

[0039] In the oral aerosol of the present invention, from the viewpoint of ensuring the expression of excellent foam performance, the mass ratio of the content of carbon dioxide in the propellant (Y) to the content of component (a) in the concentrate (X) (carbon dioxide / (a)) is preferably 0.02 or more, more preferably 0.18 or more, even more preferably 0.2 or more, still more preferably 0.25 or more, still more preferably 0.35 or more, preferably 5 or less, more preferably 3 or less, even more preferably 2.5 or less, and still more preferably 1.5 or less.

[0040] In the oral aerosol of the present invention, from the viewpoint of ensuring the expression of excellent foam performance, the mass ratio of the content of carbon dioxide in the propellant (Y) to the content of component (b) in the concentrate (X) (carbon dioxide / (b)) is preferably 0.02 or more, more preferably 0.25 or more, even more preferably 0.5 or more, still more preferably 0.8 or more, and preferably 25 or less, more preferably 20 or less, even more preferably 12 or less, and still more preferably 6 or less.

[0041] The oral aerosol of the present invention is prepared by compressing the propellant (Y) and filling it into an aerosol container. From the viewpoint of enabling the aerosol to be sprayed from the container upon use to form a foam with excellent performance, the aerosol container preferably has a foam outlet. To produce the oral aerosol of the present invention, the concentrate (X) is prepared, then filled into an aerosol container together with the propellant (Y), and then, if necessary, pressurized and sealed. The pressure inside the aerosol container is preferably 0.5 to 0.9 MPa, more preferably 0.7 to 0.8 MPa, at 25°C, from the viewpoint of ensuring the development of excellent foam performance.

[0042] When using the oral aerosol of the present invention, the contents are preferably sprayed from the container, placed on a toothbrush, fingertip, etc., and then applied to the desired area. The amount of the oral aerosol of the present invention to be applied per use is preferably 0.4 to 1.5 g, more preferably 0.5 to 1.0 g.

[0043] In relation to the above-described embodiment, the present invention further discloses the following oral aerosol: [1] An oral aerosol comprising a concentrate (X) and a propellant (Y), wherein the concentrate (X) contains the following components (a), (b), and (c): (a) a monohydric alcohol having from 12 to 22 carbon atoms in an amount of from 0.6 to 10% by mass, (b) a surfactant, and (c) water, wherein the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the concentrate (X) is from 0.08 to 10, and the ethanol content is 8% by mass or less. [2] The oral aerosol of the above [1], wherein component (a) is preferably one or more selected from cetanol, and stearyl alcohol, lauryl alcohol, myristyl alcohol, and behenyl alcohol, more preferably one or two selected from cetanol and stearyl alcohol, and further preferably contains both cetanol and stearyl alcohol as component (a). [3] The oral aerosol of the above [1] or [2], wherein the content of component (a) in the concentrate solution (X) is preferably 0.8% by mass or more, more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, and 10% by mass or less, preferably 8% by mass or less, more preferably 5% by mass or less, and further preferably 3% by mass or less.

[0044] [4] The oral aerosol of any one of [1] to [3] above, wherein component (b) is preferably one or more selected from nonionic surfactants, anionic surfactants, and amphoteric surfactants, more preferably a nonionic surfactant, even more preferably an ester-type nonionic surfactant, even more preferably one or more selected from sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, and even more preferably both a sorbitan fatty acid ester and a polyoxyethylene sorbitan fatty acid ester. [5] The oral aerosol of any one of [1] to [4] above, wherein the content of component (b) in the concentrate solution (X) is preferably 0.03% by mass or more, more preferably 0.08% by mass or more, even more preferably 0.15% by mass or more, still more preferably 0.3% by mass or more, and even more preferably 0.5% by mass or more, preferably 15% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, and even more preferably 1.8% by mass or less. [6] The oral aerosol of any one of [1] to [5] above, wherein the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the concentrate (X) is preferably 0.1 or more, more preferably 0.14 or more, even more preferably 0.23 or more, still more preferably 0.3 or more, preferably 7 or less, more preferably 3 or less, even more preferably 2 or less, still more preferably 1.5 or less, and even more preferably 0.8 or less.

[0045] [7] The oral aerosol of any one of [1] to [6] above, wherein the content of component (c) in the concentrate (X) is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 71% by mass or more, still more preferably 74% by mass or more, and preferably 98% by mass or less, more preferably 95% by mass or less, even more preferably 85% by mass or less, and still more preferably 80% by mass or less. [8] The oral aerosol of any one of [1] to [7] above, wherein the content of ethanol in the concentrate (X) is preferably 6% by mass or less, more preferably 4% by mass or less, even more preferably 2% by mass or less, still more preferably 0.4% by mass or less, or preferably the concentrate (X) does not contain ethanol. [9] The content of the binder in the concentrate (X) is preferably 1% by mass or less, more preferably 0.8% by mass or less, even more preferably 0.6% by mass or less, and still more preferably 0.05% by mass or less.

[10] The oral aerosol of any one of the above [1] to [9], wherein the concentrate (X) may contain one or more polyols (d) selected from glycerin, propylene glycol, ethylene glycol, sorbitol, xylitol, erythritol, reduced palatinose, and mannitol, and the component (d) is preferably one or more selected from glycerin, sorbitol, xylitol, erythritol, reduced palatinose, and mannitol, and more preferably one or more selected from glycerin, sorbitol, xylitol, and erythritol.

[11] The oral aerosol of the above

[10] , wherein the content of component (d) in the concentrate (X) is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 18% by mass or less, and even more preferably 8% by mass or less, or the concentrate (X) does not necessarily contain component (d).

[0046]

[12] The oral aerosol of any one of the above [1] to

[11] , wherein the propellant (Y) preferably contains carbon dioxide, and the content of carbon dioxide in the propellant (Y) is preferably 51% by mass or more, more preferably 80% by mass or more, even more preferably 90% by mass or more, still more preferably 95% by mass or more, and preferably 100% by mass or less, more preferably 100% by mass.

[13] The oral aerosol of any one of the above [1] to

[12] , wherein the mass ratio of the concentrate (X) to the propellant (Y) ((X):(Y)) is preferably 95:5 to 99:1, more preferably 97:3 to 98.5:1.5.

[14] The oral aerosol of the above

[12] or

[13] , wherein the mass ratio of the content of carbon dioxide in the propellant (Y) to the content of component (a) in the concentrate (X) (carbon dioxide / (a)) is preferably 0.02 or more, more preferably 0.18 or more, even more preferably 0.2 or more, still more preferably 0.25 or more, still more preferably 0.35 or more, preferably 5 or less, more preferably 3 or less, even more preferably 2.5 or less, and still more preferably 1.5 or less.

[15] The oral aerosol of any one of the above

[12] to

[14] , wherein the mass ratio of the content of carbon dioxide in the propellant (Y) to the content of component (b) in the concentrate (X) (carbon dioxide / (b)) is preferably 0.02 or more, more preferably 0.25 or more, even more preferably 0.5 or more, still more preferably 0.8 or more, preferably 25 or less, more preferably 20 or less, even more preferably 12 or less, and still more preferably 6 or less.

[0047] The present invention will be described in detail below with reference to the following examples. Unless otherwise specified in the tables, the content of each component is expressed in mass %.

[0048] [Examples 1 to 33, Comparative Examples 1 to 7] Each concentrate (X) was prepared according to the formulations in Tables 1 to 6, and then filled into an aerosol container (manufactured by Takeuchi Press Co., Ltd.). Then, propellant (Y) was added in the proportions shown in Tables 1 to 6, and the pressure inside the container at 25°C was set to 0.9 MPa to produce each agent. Using the resulting agents, measurements and evaluations were carried out according to the following methods. The results are shown in Tables 1 to 6.

[0049] Viscosity of the original solution (X) at 25° C.: Measurement was performed using a BM type viscometer (rotor No. 3, 12 rpm, 1 minute) (manufactured by Toki Sangyo Co., Ltd.).

[0050] <<Foam Retention Ability>> An O-ring with an inner diameter of 21.7 mm was placed on a sieve (No. 5.5, 3350 μm), and then 1 g of each agent was sprayed from a container and allowed to stand inside the O-ring. After standing, whether the sprayed foam agent passed through the sieve and dripped downward was observed from above the sieve, and the time (seconds) from immediately after ejection until the foam agent dripped was measured and used as an index of evaluation.

[0051] <Evaluation of gum-coating sensation> The sensation of the gums being protected by a smooth film (the sensation of the gums being coated) was evaluated. Specifically, about 0.5 g of each agent was sprayed from the container onto a toothbrush as foam, and after brushing for 3 minutes and rinsing, the sensation around the gums as palpated with the tongue was evaluated according to the following criteria. A photograph of the sprayed agent of Example 1 is shown in Figure 1, and a photograph of the sprayed agent of Comparative Example 1 is shown in Figure 2. 3: The sensation of the gums being protected by a smooth film was sufficiently obtained. 2: The sensation of the gums being protected by a smooth film was somewhat sufficient. 1: The sensation of the gums being protected by a smooth film was hardly obtained.

[0052] The agents obtained in Examples 1 and 16 were stored for one year at room temperature (25°C), and then the foam retention and gum-coating feeling were measured and evaluated again in the same manner as above, resulting in the following results: Example 1: Foam retention: over 300 seconds, gum-coating feeling: 3 Example 16: Foam retention: over 300 seconds, gum-coating feeling: 2

[0053]

[0054]

[0055]

[0056]

[0057]

[0058]

[0059] <Evaluation of oral irritation> Using each of the agents obtained in Example 1, Example 6, and Comparative Example 6, approximately 0.5 g of foam was sprayed onto a toothbrush from each container, and after brushing for 3 minutes and rinsing, the presence or absence of oral irritation was evaluated. As a result, no irritation was felt in Examples 1 and 6, but irritation was felt in Comparative Example 6.

Claims

1. An oral aerosol preparation comprising a concentrate (X) and a propellant (Y), wherein the concentrate (X) contains the following components (a), (b), and (c): (a) Monohydric alcohol having 12 to 22 carbon atoms: 0.6% by mass to 10% by mass (b) surfactant (c) water Contains An oral aerosol preparation in which the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the original solution (X) is 0.08 or more and 10 or less, and the content of ethanol is 8 mass% or less.

2. 2. The oral aerosol according to claim 1, wherein the component (b) is one or more members selected from the group consisting of sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters.

3. 3. The oral aerosol according to claim 1, wherein the content of the binder in the concentrate (X) is 1% by mass or less.

4. 3. The oral aerosol according to claim 1, wherein the propellant (Y) contains carbon dioxide.

5. 5. An oral aerosol according to claim 4, wherein the mass ratio (carbon dioxide / (a)) of the carbon dioxide content in the propellant (Y) to the component (a) content in the concentrate (X) is 0.02 or more and 5 or less.

6. 5. The oral aerosol according to claim 4, wherein the mass ratio (carbon dioxide / (b)) of the carbon dioxide content in the propellant (Y) to the component (b) content in the concentrate (X) is 0.02 or more and 25 or less.