Ionizable lipidoid composition and therapeutic use thereof
KR1020260113064APending Publication Date: 2026-07-21FLAGSHIP PIONEERING INNOVATIONS VII LLC
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Patent Information
- Authority / Receiving Office
- KR · KR
- Patent Type
- Applications
- Current Assignee / Owner
- FLAGSHIP PIONEERING INNOVATIONS VII LLC
- Filing Date
- 2024-11-14
- Publication Date
- 2026-07-21
AI Technical Summary
Technical Problem
The effective targeted delivery of biologically active substances, such as small molecule drugs, proteins, and nucleic acids, is challenging due to their instability and low cellular permeability, necessitating the development of compositions that facilitate safe, efficient, and specific delivery to cells.
Method used
The use of lipidoid compounds, specifically those conforming to Formulas I through VII, to form lipid nanoparticles that enhance the delivery of therapeutic agents like nucleic acids and proteins by improving cellular uptake.
Benefits of technology
The lipidoid nanoparticles effectively deliver therapeutic agents, demonstrating enhanced cellular uptake and safety profiles, making them suitable for various applications including vaccination and gene therapy.
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Smart Images
Figure PCT00192_ABST
Abstract
A lipidoid compound having the structure of Formula I or a pharmaceutically acceptable salt thereof is disclosed: [Chemical Formula I] (In the above formula, gi is as defined in the present application). Additionally, a nanoparticle composition comprising a lipidoid of the present invention capable of delivering a therapeutic agent is disclosed. The present application also discloses a pharmaceutical composition comprising a lipidoid composition of the present invention.
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