DELIVERY SYSTEM FOR PROVIDING SELF-INDUCED CALCIUM SILICATE-BASED COMPOSITIONS USED IN MEDICAL APPLICATIONS

Abstract

The present invention relates to the field of delivery and / or injection systems, preferably for medical applications. In particular, the present invention relates to a set of parts for providing a self-hardening dental composition. The set of parts of the invention comprises a first impermeable container comprising an anhydrous calcium silicate phase; and a second container comprising an aqueous phase. The set of parts of the invention can be used in delivery and / or injection systems to provide a homogeneous calcium silicate-based composition having a volume ratio between the calcium silicate phase and the aqueous phase ranging from 1 to 3. The present invention also relates to the hardened material obtained from the set of parts and the delivery and / or injection system of the invention. Summary Figure: Figure 1.

Claims

1. A kit of parts for providing a calcium silicate-based cement, said kit of parts comprising a first container and a second container, wherein: the first container is watertight and comprises an anhydrous calcium silicate semisolid comprising calcium silicate particles, a non-aqueous vehicle and optionally, a radiopacifier; the second container comprises an aqueous semisolid comprising purified water, a radiopacifier and a setting accelerator; the volume ratio between the anhydrous calcium silicate semisolid and the aqueous semisolid ranges from 1 to 10, preferably from 1 to 5, more preferably approximately 1; and provided that said first and second containers do not comprise any phosphorus compound.

2. A supply system for supplying a self-hardening calcium silicate-based cement, said system comprising the equipment parts according to claim 1 and a mixing chamber.

3. The supply system of claim 2, further comprising a piston.

4. The parts kit or delivery system according to any of claims 1 to 3, wherein the non-aqueous vehicle is selected from glycol compounds and / or silicones and mixtures thereof, preferably the non-aqueous solvent is a glycol compound, more preferably propylene glycol.

5. The parts kit or delivery system according to any of claims 1 to 4, wherein the size of the calcium silicate particles ranges from 0.01 pm to 50 pm, preferably from 0.1 pm to 30 pm, more preferably from 0.1 pm to 10 pm.

6. The kit of parts or the delivery system according to any of claims 1 to 5, wherein the radiopacifier is selected from the group comprising bismuth oxide, strontium carbonate, barium sulfate, tantalum oxide, cerium oxide, tin oxide, zirconium oxide compounds and radiopaque glasses containing tantalum, barium and strontium, and mixtures thereof, preferably the radiopacifier is a bismuth derivative, such as bismuth oxides or bismuth carbonates or mixtures thereof, or zirconium derivatives, especially zirconium oxide alone or in combination with yttrium; or a mixture of bismuth derivatives and zirconium derivatives.

7. The parts kit or delivery system according to any of claims 1 to 6, wherein the setting accelerator is selected from calcium carbonate, calcium oxide, sodium bicarbonate, calcium lactate, calcium chloride and mixtures thereof, preferably calcium chloride.

8. The assembly of parts or the delivery system according to any of claims 1 to 7, wherein the calcium silicate semi-solid and / or aqueous semi-solid further comprises additives, preferably selected from pH stabilizing agents, setting accelerators, surfactants, fillers, texturizing / thickening agents, water-reducing agents and mixtures thereof.

9. The parts kit or delivery system according to any one of claims 1 to 8, wherein the first container comprises a calcium silicate semisolid consisting of: 50 to 90% tricalcium silicate particles, 10 to 50% of a non-aqueous vehicle, preferably selected from glycol, more preferably propylene glycol, 0% to 25% of a radiopacifier, and 0% to 5% of additives; by weight to the total weight of the calcium silicate semisolid; and wherein the second container comprises an aqueous semisolid consisting of: 10 to 50% purified water, 10 to 75% of a setting accelerator, preferably calcium chloride, 10% to 80% of a radiopacifier, preferably zirconium oxide, and 0% to 20% of additives; by weight to the total weight of the aqueous semi-solid.

10. The assembly or delivery system according to any of claims 1 to 9, wherein the first container comprises an anhydrous calcium silicate semisolid consisting of tricalcium silicate particles and propylene glycol; and the second container comprises an aqueous semisolid consisting of purified water, calcium chloride, zirconium oxide, and additives. 5 11. A kit of parts or a delivery system according to any of claims 1 to 10, suitable for treating a bone and / or dental disorder or disease in a subject in need; preferably in bone and / or dental restoration or in bone and / or dental filling.

12. A hardened material obtainable by means of the parts equipment or the 10 delivery system according to any of claims 1 to 10.

13. The hardened dental material according to claim 12, wherein its compressive strength ranges from more than 0 to 300 MPa, preferably from 0.5 to 100 MPa, more preferably from 0.5 to 30 MPa.