3-Z-[1-(Piperidin-1-YL-Methyl)-Anilino)-1-Phenyl-Methylene]-6-Ethoxycarbonyl-2-lndolinone compound and pharmaceutical composition comprising thereof

Abstract

The present invention relates to indolinone general formula. substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, which have valuable pharmacological properties, especially an inhibitory effect on receptor tyrosine kinases and cyclin / CDK complexes, as well as on the proliferation of endothelial cells and various tumour cells, pharmaceutical composition containing this compound their use and processes for preparing them.