Chip positioning apparatus, chip outer frame apparatus for gene sequencer, and gene sequencer

Abstract

Provided are a chip positioning apparatus, a chip outer frame apparatus for a gene sequencer, and a gene sequencer. The chip positioning apparatus is used for positioning a chip, and comprises: a base used for carrying said chip; a first limiting structure fixedly connected to the base and used for abutting against the chip so as to limit the movement of the chip in a first direction and a second direction, the first direction and the second direction being perpendicular to one another; a second limiting structure movably connected to the base and used for abutting against the chip so as to limit the movement of the chip in the direction opposite the first direction and the direction opposite the second direction; and an execution structure connected to the base and abutting against and holding the second limiting structure, used for pushing the second limiting structure to move in the first direction and the second direction such that the second limiting structure abuts against the chip. By using the execution structure, the position of the chip in the first direction on the horizontal plane and the position of the chip in the second direction on the horizontal plane can be determined simultaneously, thus effectively improving chip positioning efficiency.

Description

Chip positioning device, chip outer frame device for gene sequencer, and gene sequencer

[0001] This application claims priority to the Chinese patent application number 202322038680.3, filed with the Patent Office of China on July 28, 2023, with application name “Chip positioning device and chip processing device”; the Chinese patent application number 202323165477.9, filed with the Patent Office of China on November 22, 2023, with application name “A chip holder for a gene sequencer”; and the Chinese patent application number 202310699027.3, filed with the Patent Office of China on June 13, 2023, with application name “A chip frame device for a gene sequencer”, all of which are incorporated by reference into this application. Technical Field

[0002] The present application relates to the field of chip processing gene sequencing, and specifically, to a chip positioning device, a chip frame device for a gene sequencer, and a gene sequencer. Background Art

[0003] When a biochip is in use, it needs to be fixed at a preset position. The accuracy of its position is directly related to the accuracy of the experimental results. In related technologies, the process of fixing the position of the biochip is relatively cumbersome and needs to be fixed separately from different directions, which is not easy to operate.

[0004] Summary of the Invention

[0005] The purpose of this application is to provide a chip positioning device, a chip frame device for a gene sequencer, and a gene sequencer, which can quickly position the chip.

[0006] The embodiment of the present application is implemented as follows:

[0007] In a first aspect, a chip positioning device is provided for positioning a chip in a gene sequencer, the device comprising:

[0008] a base, used for carrying the chip;

[0009] a first limiting structure, fixedly connected to the base, for abutting against the chip to limit the movement of the chip along a first direction and a second direction; wherein the first direction and the second direction are perpendicular to each other;

[0010] a second limiting structure, movably connected to the base, and configured to abut against the chip to limit movement of the chip in a direction opposite to the first direction and in a direction opposite to the second direction;

[0011] The execution structure is connected to the base and abuts against the second limiting structure, and is used to push the second limiting structure to move along the first direction and the second direction to abut against the chip.

[0012] In a specific embodiment, the second limiting structure forms an abutting surface, and the abutting surface is inclined from a direction opposite to the first direction toward a direction opposite to the second direction;

[0013] The execution structure includes an abutment and an elastic member; the elastic member is connected to the base and the abutment, and is used to push the abutment to move; the abutment abuts against the abutment surface to push the second limiting structure to move along the first direction and the second direction under the action of the elastic member.

[0014] In a specific possible implementation manner, the abutment member is rotatably connected to the base, and the rotation axis of the abutment member is parallel to the second direction.

[0015] In a specific possible implementation scheme, one end of the elastic member is fixedly connected to the base, and the other end of the elastic member is fixedly connected to one end of the abutment member, and the elastic member is used to push the abutment member to rotate toward a direction close to the second limiting structure.

[0016] In a specific possible implementation scheme, a pressing portion is formed on the abutment member, and the pressing portion is arranged on the side of the abutment member away from the elastic member. The pressing portion is used to receive external force and rotate in a direction away from the second limiting structure under the action of the external force.

[0017] In a specific embodiment, the first limiting structure includes:

[0018] a first limiting member, fixedly connected to the base, and configured to abut against the chip to limit movement of the chip along the first direction;

[0019] The second limiting member is fixedly connected to the base and is used to abut against the chip to limit the movement of the chip along the second direction.

[0020] In a specific possible implementation scheme, the second limiting structure is annular, and a cavity for accommodating the chip is formed inside the second limiting structure; the second limiting structure has a first inner wall and a second inner wall, the first inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the first direction; the second inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the second direction.

[0021] In a specific embodiment, the second limiting structure forms an opening, the opening is connected to the cavity, and the opening is used to accommodate the first limiting member and the second limiting member.

[0022] In a specific embodiment, it also includes:

[0023] The cover is rotatably connected to the base and is used for pressing the chip when the cover is close to the base.

[0024] In a specific embodiment, at least two groups of pressure claw assemblies are symmetrically installed on the lower surface of the cover body, and the at least two groups of pressure claw assemblies abut against the chip when the cover body is close to the base, so as to press and fix the chip.

[0025] In a specific embodiment, the pressure claw assembly includes a pressure claw frame, a rotating shaft and a pressure claw, the pressure claw frame is rotatably connected to the rotating shaft, the pressure claw abuts between the pressure claw frame and the rotating shaft, and the pressure claw is used to press the chip.

[0026] In a specific embodiment, the pressure claw assembly further includes a spring, one end of the pressure claw is used to press the chip, and the other end of the pressure claw is fixedly connected to the pressure claw frame through the spring.

[0027] In a specific embodiment, the pressure jaw assembly further includes a support member, the pressure jaw is placed between the support member and the rotating shaft, and the middle portion of the pressure jaw abuts against the support member.

[0028] In a specific embodiment, the contact portion between the pressing claw and the supporting member has an arc-shaped convex surface, and the pressing claw can rotate along the arc-shaped convex surface to adapt to the angle of the chip.

[0029] In a specific possible implementation scheme, a limiting groove is provided on the top of the pressing claw, and the rotating shaft passes through the limiting groove and is rotatably connected to the pressing claw frame.

[0030] In a specific embodiment, the contact surface between the pressure claw and the chip is a flexible structure, and the flexible structure is one of a rubber pad, a sponge pad and polyurethane foam.

[0031] In a specific embodiment, the chip is provided with multiple groups of flow channels arranged along its length direction, and fluid ports are opened on both sides of the flow channels along the thickness direction of the chip, and the fluid ports are connected to the flow channel ports in the base.

[0032] In a second aspect, a chip frame device for a gene sequencer is provided, the device comprising a chip frame, a chip, and a sealing gasket, wherein the chip frame is provided with a chip slot, the chip is disposed in the chip slot, and the chip slot is provided with a first fixing mechanism for fixing the chip;

[0033] The sealing gasket is detachably mounted on the bottom of the chip frame;

[0034] The chip is provided with a plurality of horizontal and mutually parallel fluid grooves, the lower end surface of the chip is provided with a fluid port connected to both ends of the fluid groove, the sealing gasket is provided with a fluid circular hole, and the fluid port and the fluid circular hole are connected in sequence.

[0035] In a specific embodiment, the sealing gasket is provided with a plug-in groove for engaging with the plug-in boss of the gene sequencer.

[0036] In a specific possible implementation scheme, the first fixing mechanism includes an upper limit plate and a lower limit plate, and there are at least one pair of upper limit plates and lower limit plates respectively. The at least one pair of upper and lower limit plates are respectively fixedly mounted on the inner walls on opposite sides of the chip outer frame, and the chip is accommodated in the groove formed between the upper limit plate and the lower limit plate.

[0037] In a specific possible implementation scheme, the first fixing mechanism also includes a limiting boss, which is fixedly mounted on the inner side wall of the chip outer frame. Each inner side wall of the chip outer frame is provided with at least one limiting boss, and the limiting boss has a contact surface that conflicts with the side wall of the chip.

[0038] In a specific embodiment, the contact surface is a plane, a curved surface or a spherical surface.

[0039] In a specific possible implementation scheme, the limiting boss located on the front side is an elastic boss, which is fixedly mounted on the inner wall of the chip outer frame through an elastic sheet and has an elastic force to press toward the inner side of the chip slot.

[0040] In a specific possible implementation scheme, the limiting boss on the left side has an inclined surface that tilts inward from top to bottom, and the lower end of the inclined surface is transitionally connected to the contact surface on the limiting boss.

[0041] In a specific embodiment, a hook is fixedly provided at the bottom of the chip frame, a hanging hole for the hook to be inserted is opened on the sealing gasket, and the sealing gasket is connected to the hook at the bottom of the chip frame through the hanging hole.

[0042] In a specific possible implementation scheme, a limiting notch is provided on the chip outer frame and corresponds to a positioning reference on the gene sequencer, and the positioning reference is embedded in the limiting notch.

[0043] In a specific embodiment, the outer wall of the chip frame has a positioning groove for positioning with a positioning element on the gene sequencer. When the positioning element is in the retracted position, the positioning element is separated from the positioning groove.

[0044] In a third aspect, a gene sequencer is provided, the gene sequencer including a chip platform for carrying a chip;

[0045] a first limiting structure, fixedly connected to the chip platform, for abutting against the chip to limit movement of the chip along a first direction and a second direction; wherein the first direction and the second direction are perpendicular to each other;

[0046] a chip outer frame, movably connected to the chip platform, the chip outer frame being provided with a chip slot, the chip being arranged in the chip slot to restrict the chip from moving in a direction opposite to the first direction and in a direction opposite to the second direction;

[0047] an execution structure, connected to the chip platform and abutting against the chip frame, for pushing the chip frame to move along the first direction and the second direction to abut against the chip;

[0048] A sealing gasket, detachably mounted on the bottom of the chip frame;

[0049] A sealing block corresponding to the position of the sealing gasket is provided on the chip platform;

[0050] The chip is provided with a plurality of horizontal and mutually parallel fluid grooves inside, the lower end surface of the chip is provided with a fluid port connected with both ends of the fluid groove, the sealing gasket is provided with a fluid circular hole, and the sealing block is provided with a flow channel opening, and the fluid port, the fluid circular hole and the flow channel opening are connected in sequence.

[0051] In a specific embodiment, the chip frame forms an abutting surface, and the abutting surface is inclined from a direction opposite to the first direction toward a direction opposite to the second direction;

[0052] The execution structure includes an abutment and an elastic member; the elastic member is connected to the chip platform and the abutment to push the abutment to move; the abutment abuts against the abutment surface to push the chip frame to move along the first direction and the second direction under the action of the elastic member.

[0053] In a specific embodiment, the abutment member is rotatably connected to the chip platform, and the rotation axis of the abutment member is parallel to the second direction.

[0054] In a specific possible implementation scheme, one end of the elastic member is fixedly connected to the chip platform, and the other end of the elastic member is fixedly connected to one end of the abutment member, and the elastic member is used to push the abutment member to rotate toward the direction close to the chip frame.

[0055] In a specific possible implementation scheme, a pressing portion is formed on the abutment member, and the pressing portion is arranged on a side of the abutment member away from the elastic member. The pressing portion is used to receive external force and rotate in a direction away from the chip frame under the action of the external force.

[0056] In a specific embodiment, the first limiting structure includes:

[0057] a first limiting member, fixedly connected to the chip platform and configured to abut against the chip to limit movement of the chip along the first direction;

[0058] The second limiting member is fixedly connected to the chip platform and is used to abut against the chip to limit the movement of the chip along the second direction.

[0059] In a specific possible implementation scheme, the chip outer frame is annular, and a cavity for accommodating the chip is formed inside the chip outer frame; the chip outer frame has a first inner wall and a second inner wall, the first inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction along the first direction; the second inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction along the second direction.

[0060] In a specific embodiment, the chip frame forms an opening, the opening is connected to the cavity, and the opening is used to accommodate the first limiting member and the second limiting member.

[0061] In a specific embodiment, it also includes:

[0062] The cover is rotatably connected to the chip platform and is used for pressing the chip when the cover is close to the chip platform.

[0063] In a specific embodiment, at least two groups of pressure claw assemblies are symmetrically installed on the lower surface of the cover, and the at least two groups of pressure claw assemblies abut against the chip when the cover is in a closed state to press and fix the chip.

[0064] In a specific embodiment, the pressure claw assembly includes a pressure claw frame, a rotating shaft and a pressure claw, the pressure claw frame is rotatably connected to the rotating shaft, the pressure claw abuts between the pressure claw frame and the rotating shaft, and the pressure claw is used to press the chip.

[0065] In a specific embodiment, the pressure claw assembly further includes a spring, one end of the pressure claw is used to press the chip, and the other end of the pressure claw is fixedly connected to the pressure claw frame through the spring.

[0066] In a specific embodiment, the pressure jaw assembly further includes a support member, the pressure jaw is placed between the support member and the rotating shaft, and the middle portion of the pressure jaw abuts against the support member.

[0067] In a specific embodiment, the contact portion between the pressing claw and the supporting member has an arc-shaped convex surface, and the pressing claw can rotate along the arc-shaped convex surface to adapt to the angle of the chip.

[0068] In a specific possible implementation scheme, a limiting groove is provided on the top of the pressing claw, and the rotating shaft passes through the limiting groove and is rotatably connected to the pressing claw frame.

[0069] In a specific possible implementation scheme, a first fixing mechanism for fixing the chip is provided on the chip slot; the first fixing mechanism includes an upper limit plate and a lower limit plate, and there are at least one pair of upper limit plates and lower limit plates respectively, and at least one pair of upper and lower limit plates are respectively fixedly installed on the inner walls on opposite sides of the chip outer frame, and the chip is accommodated in the groove formed between the upper limit plate and the lower limit plate.

[0070] In a specific possible implementation scheme, the first fixing mechanism also includes a limiting boss, which is fixedly mounted on the inner side wall of the chip outer frame. Each inner side wall of the chip outer frame is provided with at least one limiting boss, and the limiting boss has a contact surface that conflicts with the side wall of the chip.

[0071] In a specific embodiment, the contact surface is a plane, a curved surface or a spherical surface.

[0072] In a specific possible implementation scheme, the limiting boss located on the front side is an elastic boss, which is fixedly mounted on the inner wall of the chip outer frame through an elastic sheet and has an elastic force to press toward the inner side of the chip slot.

[0073] In a specific possible implementation scheme, the limiting boss located on the left side has an inclined surface that tilts inward from top to bottom, and the lower end of the inclined surface is transitionally connected to the contact surface on the limiting boss.

[0074] The beneficial effects of this application are:

[0075] The embodiment of the present application positions the chip in different orientations through the cooperation of various mechanisms, which can effectively improve the positioning efficiency of the chip. BRIEF DESCRIPTION OF THE DRAWINGS

[0076] To more clearly illustrate the technical solutions of the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present application and should not be construed as limiting the scope. A person of ordinary skill in the art of gene sequencing can derive other relevant drawings based on these drawings without inventive effort.

[0077] FIG1 is a schematic structural diagram of a chip positioning device provided in an embodiment of the present application;

[0078] FIG2 is a cross-sectional view of a chip positioning device provided in an embodiment of the present application;

[0079] FIG3 is a schematic diagram of the structure of a chip base used in a gene sequencer of the present application;

[0080] FIG4 is a schematic diagram showing the disassembled structure of the sequencing chip in FIG3 of the present application;

[0081] FIG5 is a schematic structural diagram of the pressure claw assembly in FIG3 of the present application;

[0082] FIG6 is a schematic side view of the cross-sectional structure of FIG5 of the present application;

[0083] FIG7 is a schematic diagram of the front view structure of FIG5 of the present application.

[0084] FIG8 is a schematic structural diagram of a chip frame device for a gene sequencer;

[0085] FIG9 is a schematic diagram of the back structure of a chip frame device for a gene sequencer;

[0086] FIG10 is a top view of a chip frame device for a gene sequencer;

[0087] FIG11 is a cross-sectional view of a hook portion of a chip frame device for a gene sequencer;

[0088] FIG12 is a schematic diagram of the installation structure of the chip frame and the chip platform in the chip frame device for a gene sequencer;

[0089] FIG13 is a schematic diagram of the structure of a chip platform in a chip frame device for a gene sequencer;

[0090] Icons: 100, chip split positioning device; 110, base; 120, first limiting structure; 121, first limiting member; 122, second limiting member; 130, second limiting structure; 131, abutting surface; 132, first inner wall; 133, second inner wall; 140, execution structure; 141, abutting member; 142, elastic member; 150, cover; 200, chip. 1. Sequencing chip; 2. Sequencing chip platform; 3. Pressing cover; 4. Pressing claw assembly; 41. Pressing claw frame; 42. Rotating shaft; 43. Pressing claw; 44. Spring; 45. Support member; 46. Limiting groove; 5. Chip positioning block; 6. Chip frame; 7. Flow channel; 8. Fluid port; 9. Flow channel port; 11. Sealing structure; Chip outer frame 10, hook 101, elastic boss 102, limiting boss 103, upper limiting plate 104, lower limiting plate 105, positioning groove 106, limiting notch 107; Sequencing chip 20, fluid port 201, fluid tank 202; Sealing gasket 30, fluid circular hole 301, hanging hole 302, plug-in groove 303; Chip platform 40, positioning reference 401, positioning element 402, positioning head 402a; Sealing block 50, plug-in boss 501, flow channel port 502. DETAILED DESCRIPTION

[0091] To make the objectives, technical solutions, and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Generally, the components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations.

[0092] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but rather merely represents selected embodiments of the present application. All other embodiments derived by persons of ordinary skill in the art of gene sequencing based on the embodiments herein without inventive effort are also within the scope of protection of this application.

[0093] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0094] In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings, or are the orientation or positional relationship in which the product of the application is usually placed when in use. They are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0095] Furthermore, terms such as "horizontal," "vertical," and "overhanging" do not necessarily imply that a component must be absolutely horizontal or overhanging, but rather that it can be slightly tilted. For example, "horizontal" simply means that its direction is more horizontal than "vertical," and does not mean that the structure must be completely horizontal, but rather that it can be slightly tilted.

[0096] In the description of the embodiments of this application, it should also be noted that, unless otherwise expressly specified or limited, the terms "disposed," "installed," "connected," and "connected" should be understood broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections or electrical connections; direct connections or indirect connections through an intermediary; and internal connections between two components. Those skilled in the art of gene sequencing will understand the specific meanings of these terms in the embodiments of this application on a case-by-case basis.

[0097] 1 and 2 , an embodiment of the present application provides a chip separation positioning device 100 , which includes a base 110 , a first limiting structure 120 , a second limiting structure 130 , and an execution structure 140 .

[0098] The base 110 is used to carry the chip 200. Specifically, a plane may be formed on the base 110, and the plane may be parallel to a horizontal plane. When the chip 200 is carried on the base 110, the chip 200 is on the horizontal plane. The position of the chip 200 can be determined by simply controlling the position of the chip 200 on the horizontal plane.

[0099] The first limiting structure 120 is fixedly connected to the base 110 and is configured to abut against the chip 200. When the first limiting structure 120 abuts against the chip 200, the first limiting structure 120 can restrict the movement of the chip 200 along a first direction and a second direction. The first direction and the second direction can both be horizontal and perpendicular to each other.

[0100] Specifically, the first limiting structure 120 may include: a first limiting member 121 and a second limiting member 122. The first limiting member 121 is fixedly connected to the base 110 and is used to abut against the chip 200 to limit the movement of the chip 200 in the first direction. That is, the first limiting member 121 is arranged on the path of the chip 200 moving in the first direction to prevent the chip 200 from continuing to move in the first direction. The second limiting member 122 is fixedly connected to the base 110 and is used to abut against the chip 200 to limit the movement of the chip 200 in the second direction. That is, the second limiting member 122 is arranged on the path of the chip 200 moving in the second direction to prevent the chip 200 from continuing to move in the second direction. Specifically, the first limiting member 121 and the second limiting member 122 can both be set as columnar structures, and the side walls of the columnar structures can abut against the chip 200 to prevent the chip 200 from moving.

[0101] The second limiting structure 130 is movably connected to the base 110 and is used to abut against the chip 200. When the second limiting structure 130 abuts against the chip 200, the second limiting structure 130 can limit the chip 200 from moving in directions opposite to the first direction and the second direction.

[0102] The chip positioning device provided in the embodiment of the present application includes: a base, a first limiting structure, a second limiting structure and an execution structure. The base is used to carry the chip. The base can be used to place the chip on a horizontal plane to determine the position of the chip in the vertical direction; the first limiting structure is fixedly connected to the base, the first limiting structure is used to abut the chip, and the first limiting structure is used to limit the movement of the chip along the first direction and the second direction. The first direction and the second direction can both be horizontal directions. In the horizontal direction, the position of the chip on the horizontal plane can be fixed by only making the chip closely fit against the first limiting structure; the second limiting structure is movably connected to the base, the second limiting structure is used to abut the chip, and the second limiting structure is used to limit the movement of the chip in the opposite direction of the first direction and the opposite direction of the second direction. The second limiting structure can be used to abut the first limiting structure to fix the position of the chip; the execution structure is connected to the base and abuts the second limiting structure. The execution structure is used to push the second limiting structure to move along the first direction and the second direction to abut against the chip; the execution structure can push the second limiting structure to move along the first direction and the second direction, so that the chip is closely fitted with the first limiting structure and the second limiting structure, thereby realizing the determination of the position of the chip.

[0103] Therefore, the execution structure can be used to simultaneously determine the position of the chip in the first direction and the second direction on the horizontal plane, which can effectively improve the positioning efficiency of the chip.

[0104] Specifically, the second limiting structure 130 can be configured as an annular structure, with a cavity formed inside the second limiting structure 130 for accommodating the chip 200. When the chip 200 is placed in the cavity, the two inner walls of the second limiting structure 130, namely the first inner wall 132 and the second inner wall 133, can fit tightly against the chip 200. The first inner wall 132 is used to abut the chip 200 to limit the movement of the chip 200 in the opposite direction of the first direction; the second inner wall 133 is used to abut the chip 200 to limit the movement of the chip 200 in the opposite direction of the second direction. The first inner wall 132 and the second inner wall 133 can be perpendicular to each other. Since the second limiting structure 130 is an annular structure, the relative positional relationship between the first inner wall 132 and the second inner wall 133 remains fixed. Therefore, by controlling the second limiting structure 130, the first inner wall 132 and the second inner wall 133 can be controlled simultaneously, facilitating the determination of the position of the chip 200.

[0105] The actuator structure 140 is connected to the base 110 and abuts against the second limiting structure 130. The actuator structure 140 is used to push the second limiting structure 130 to move in the first direction and the second direction so that the second limiting structure 130 abuts the chip 200. The actuator structure 140 can be used to push the second limiting structure 130 in the first direction and the second direction, thereby abutting the chip 200, and push the chip 200 to abut the first limiting structure 120, thereby determining the position of the chip 200.

[0106] Specifically, the second limiting structure 130 forms an abutting surface 131, which is inclined from the opposite direction of the first direction to the opposite direction of the second direction. When the execution structure 140 abuts against the abutting surface 131, the second limiting structure 130 can be pushed to move in the first direction and the second direction at the same time.

[0107] The actuator structure 140 includes an abutment member 141 and an elastic member 142. The abutment member 141 abuts the abutment surface 131 to push the second position-limiting structure 130 to move in both the first and second directions. The elastic member 142 is connected to the base 110 and the abutment member 141 and is used to push the abutment member 141 to move. Under the action of the elastic member 142, the abutment member 141 can maintain its abutment against the second position-limiting member 122, ensuring the stability of the chip 200.

[0108] In some embodiments of the present application, the abutment member 141 is rotatably connected to the base 110, and the rotation axis of the abutment member 141 is parallel to the second direction. Specifically, by utilizing the abutment member 141 rotatably connected to the base 110, not only can the abutment member 141 be moved closer to or further away from the second limiting structure 130 through rotation, but the position of the abutment member 141 can also be maintained stable, preventing the abutment member 141 from separating from the base 110.

[0109] Specifically, in some embodiments of the present application, one end of the elastic member 142 is fixedly connected to the base 110, and the other end of the elastic member 142 is fixedly connected to one end of the abutting member 141. The elastic member 142 is used to push the abutting member 141 to rotate toward the second limiting structure 130. Specifically, during the process of the abutting member 141 rotating toward the second limiting structure 130, the end of the abutting member 141 abuts against the abutting surface 131 and pushes the second limiting structure 130 to move, thereby pushing the second limiting structure 130 to move simultaneously in the first direction and the second direction, thereby determining the position of the chip 200.

[0110] In some embodiments of the present application, a pressing portion is formed on the abutment 141, and the pressing portion is arranged on the side of the abutment 141 away from the elastic member 142. Using the pressing portion, the user can apply pressure to the pressing portion so that the abutment 141 can overcome the elastic force of the elastic member 142 and rotate in a direction away from the second limiting structure 130, thereby increasing the activity space of the second limiting structure 130, which is conducive to the placement of the chip 200.

[0111] In other embodiments, the abutting member 141 may also be slidably connected to the base 110, and the elastic member 142 may cause the abutting member 141 to elastically abut against the abutting surface 131 of the second limiting structure 130. Under the elastic force of the elastic member 142, the abutting member 141 may slide in the first direction or the second direction and abut against the abutting surface 131, thereby pushing the second limiting structure 130 to move in the first direction and the second direction simultaneously under the action of the abutting surface 131, thereby determining the position of the chip 200.

[0112] In some embodiments of the present application, the second retaining structure 130 forms an opening that is connected to the cavity, and the opening is used to accommodate the first retaining member 121 and the second retaining member 122. Specifically, three openings can be provided, of which two first retaining members 121 are provided and one second retaining member 122 is provided, with two openings being used to accommodate the first retaining members 121 and the other opening being used to accommodate the second retaining member 122. The interaction between the openings and the first retaining member 121 and the second retaining member 122 allows for preliminary positioning of the chip 200, facilitating smooth subsequent positioning.

[0113] In some embodiments of the present application, the chip separation and positioning device 100 further includes a cover 150 .

[0114] The cover 150 is rotatably connected to the base 110 . The cover 150 is used to press the chip 200 when the cover 150 and the base 110 are close to each other, so that the vertical position of the chip 200 is further determined, thereby further ensuring the stability of the position of the chip 200 .

[0115] In some embodiments of the present application, the cover 150 includes a pressing block, which is an elastic structure. When the cover 150 is in a closed state, the pressing block presses the chip 200 to determine the position of the chip 200 in the vertical direction.

[0116] The present application also provides a chip processing device, which includes the above-mentioned chip split positioning device. The above-mentioned chip split positioning device can be used to quickly position the chip, thereby improving work efficiency.

[0117] Referring to Figures 3 to 7, the present application provides a chip holder for a gene sequencer (i.e., the chip positioning device in Figure 1), comprising a sequencing chip platform 2 (i.e., the base 110 in Figure 1) with a built-in sequencing chip 1 (i.e., the chip 200 in Figure 1), and further comprising: a pressure cover 3 (i.e., the cover body 150 in Figure 1), which is rotatably mounted on the upper surface of the sequencing chip platform 2 via an axle seat or a hinge.

[0118] The chip holder includes at least two sets of pressing claw assemblies 4 symmetrically mounted on the lower surface of the pressing cover 3 and in contact with the sequencing chip 1 for pressing and fixing the sequencing chip 1 .

[0119] Specifically, as shown in Figures 5 to 7, the pressure claw assembly 4 includes a pressure claw frame 41, a rotating shaft 42 and a pressure claw 43. Through grooves are provided on both sides of the pressure claw frame 41 to be rotatably connected to the rotating shaft 42. The pressure claw 43 abuts between the pressure claw frame 41 and the rotating shaft 42, and the pressure claw 43 is arranged in a "Z"-shaped structure. The pressure claw 43 is used to press the sequencing chip 1.

[0120] Furthermore, the pressure claw assembly 4 also includes a spring 44. One end of the pressure claw 43 is used to press the sequencing chip 1. The other end of the pressure claw 43 is fixedly connected to the pressure claw frame 41 through the spring 44 to provide pressure for the pressure claw 43 to stably press the sequencing chip 1.

[0121] Furthermore, the pressure claw assembly 4 also includes a support member 45, and the pressure claw 43 is placed between the support member 45 and the rotating shaft 42. The middle part of the pressure claw 43 abuts the support member 45, which can make the rotation of the pressure claw 43 more stable, thereby improving the stability of the pressure claw 43.

[0122] As shown in Figure 7, the contact point between the pressure claw 43 and the support member 45 has an arc-shaped convex surface. The pressure claw 43 can rotate along the arc-shaped convex surface to adapt to the angle of the sequencing chip 1 and can move slightly. Especially when there are two or more pressure claw assemblies 4 located on the pressure cover 3, when the sequencing chip 1 is pressed, multiple pressure claws 43 can contact the upper surface of the sequencing chip 1 at the same time, which is more suitable.

[0123] As shown in Figures 5 and 6, a limiting groove 46 is provided on the top of the pressure claw 43, and the rotating shaft 42 passes through the limiting groove 46 and is rotatably connected to the pressure claw frame 41, so as to facilitate limiting the pressure claw 3 and ensure stability during rotation, thereby improving the stability of the pressure claw 43 in pressing the sequencing chip 1.

[0124] Furthermore, the contact surface between the pressure claw 43 and the sequencing chip 1 is a flexible structure, which is one of a rubber pad, a sponge pad and polyurethane foam, to avoid scratches between the pressure claw 43 and the sequencing chip 1, thereby protecting the sequencing chip 1.

[0125] As shown in Figures 3 and 4, the chip seat also includes at least two groups of chip positioning blocks 5 and a chip frame 6 (i.e., the second limiting structure 130 in Figure 1). The chip positioning blocks 5 are installed on the periphery of the top of the sequencing chip platform 2, and the chip frame 6 is arranged on the periphery of the sequencing chip 1 and is located in the installation area formed between the chip positioning blocks 5. It can position the sequencing chip 1, thereby improving the accuracy of detection.

[0126] As shown in FIG3 , the top of the sequencing chip 1 is provided with multiple groups of flow channels 7 arranged along its length. Fluid ports 8 are provided on both sides of the flow channels 7 along the thickness direction of the sequencing chip 1. The fluid ports 8 are connected to the flow channel ports 9 in the sequencing chip platform 2 to facilitate the flow of test liquids.

[0127] As shown in FIG4 , the sequencing chip platform 2 further includes a sealing structure 11 , which is located between the flow channel port 9 and the fluid port 8 and is used to seal the connection between the flow channel port 9 and the fluid port 8 . The sealing structure 11 is a sealing gasket or a filling sealant to prevent leakage during the circulation of the test liquid and improve the sealing degree.

[0128] The operating principle of this embodiment is as follows: During use, the sequencing chip 1 and chip frame 6 are first assembled and placed inside the top surface of the sequencing chip platform 2. The chip is secured by chip positioning blocks 5 at the four corners to ensure accurate placement and detection precision. Subsequently, the pressure cover 3 is flipped onto the top surface of the sequencing chip platform 2. The pressure cover 3 simultaneously drives the pressure claw assembly 4 to move until the pressure claw 43 is firmly against the top surface of the sequencing chip 1, clamping and securing the sequencing chip 1. The elastic force of the spring 44, in conjunction with the rotating shaft 42 and the support member 45, forms a lever, allowing one end of the pressure claw 43 to apply a certain amount of pressure to the sequencing chip 1, maintaining stable operation of the entire clamping mechanism and clamping and positioning the edge of the sequencing chip 1. The bottom surface of the pressure claw 3, where it contacts the sequencing chip 1, is protected by a sealing cushion to prevent scratching of the sequencing chip 1 during downward pressure.

[0129] Furthermore, the sequencing chip 1 presses the sealing structure 11 vertically downward through the cooperation of the spring 44 and the pressure claw 43, so that the sealing structure 11 forms a seal between the fluid port 8 and the flow channel port 9, thereby preventing leakage when the subsequent sequencing reaction working liquid passes through. At the same time, the sequencing chip 1 is positioned and the sequencing chip 1 and internal components are protected, making it convenient to carry and use in multiple locations.

[0130] In the solution provided in the present application, by providing multiple pressure claw assemblies at the bottom of the pressure cover assembly, the sequencing chip can be tightly pressed to ensure the flatness and tightness of the sequencing chip and avoid leakage; further, the sequencing chip can be positioned and the internal sequencing chip and internal components can be protected, making it convenient to carry and use in multiple locations.

[0131] Referring to Figures 8 to 13 , this embodiment provides a chip frame device for a gene sequencer. The chip frame device is used to secure a sequencing chip 20 (i.e., the chip in Figure 1 and the sequencing chip 1 in Figure 3 ) so that the sequencing chip 20 is stably mounted on the gene sequencer and improves image acquisition clarity. The chip frame device comprises a chip frame 10 (i.e., the second retaining structure 130 in Figure 1 and the chip frame 6 in Figure 3 ), a sealing gasket 30 , a sealing block 50 (i.e., the sealing structure 11 in Figure 4 ), and a chip platform 40 (i.e., the base 110 in Figure 1 and the sequencing chip platform 2 in Figure 3 ). The chip frame 10 is a generally rectangular frame. The chip frame 10 has a chip slot for accommodating and securing the sequencing chip 20. The chip slot is provided with a first securing mechanism for securing the sequencing chip 20. The provision of the first securing mechanism ensures that the sequencing chip 20 is stably mounted within the chip slot and is stably positioned in the front-to-back, left-to-right, and up-to-down directions, thereby improving its secure installation.

[0132] The sequencing chip 20 is internally provided with multiple horizontally arranged and mutually parallel fluid grooves 202 (i.e., flow channels 7 in FIG3 ). The lower end surface of the sequencing chip 20 is provided with fluid ports 201 communicating with both ends of the fluid grooves 202. The sealing gasket 30 is removably mounted on the bottom of the chip frame 10 and corresponds to the position of the fluid ports 201 to improve the sealing at the fluid ports 201. The sealing gasket 30 is provided with fluid circular holes 301 corresponding to and communicating with the fluid ports 201, so that the fluid in the fluid grooves 202 can flow into the fluid circular holes 301 through the fluid ports 201.

[0133] The chip platform 40 serves as a substrate for supporting the chip frame 10, and secures the chip frame 10, which houses the sequencing chip 20, to the gene sequencer via the chip platform 40. A second securing mechanism is provided between the chip frame 10 and the chip platform 40. This second securing mechanism ensures that the chip frame 10 is stably mounted on the chip platform 40, thereby improving overall stability. A sealing block 50 is provided on the chip platform 40, corresponding to the position of the sealing gasket 30. A flow channel 502 is defined on the sealing block 50, corresponding to the position of the fluid hole 301. When the sequencing chip 20 and the chip frame 10 are secured to the chip platform 40, the fluid reservoir 202, the fluid port 201, the fluid hole 301, and the flow channel 502 are sequentially connected. During use, liquid flows from the sealing block on one side through the sealing gasket into the chip. After reaction within the chip, the liquid flows out through the fluid reservoir toward the sealing gasket and sealing block on the other side.

[0134] In this embodiment, preferably, a plug-in groove 303 is provided on the sealing gasket 30, and a plug-in boss 501 matching the plug-in groove 303 is fixedly installed on the sealing block 50. The sealing gasket 30 is fixedly installed on the bottom of the outer frame outside the core and is jointly installed on the chip platform 40. At this time, the plug-in groove 303 and the plug-in boss 501 are engaged with each other, thereby improving the positioning accuracy between the sealing gasket 30 and the sealing block 50, and ensuring the precise alignment of the fluid circular hole 301 and the flow channel opening 502.

[0135] In this embodiment, in order to improve the installation stability between the sequencing chip 20 and the chip frame 10, the first fixing mechanism specifically includes an upper limit plate 104, a lower limit plate 105 and a limit boss 103, wherein the upper limit plate 104 and the lower limit plate 105 each have at least one pair, and the at least one pair of upper and lower limit plates 105 are respectively fixedly mounted on the inner walls of the opposite sides of the chip frame 10, and the two pairs of upper and lower limit plates 105 are symmetrically distributed. In this embodiment, one pair of upper and lower limit plates 105 is fixedly mounted on the front inner wall of the chip frame 10, and the other pair of upper and lower limit plates 105 is fixedly mounted on the rear inner wall of the chip frame 10. A groove for limiting the upper and lower positions of the sequencing chip 20 is formed between the upper limit plate 104 and the lower limit plate 105. During installation, the lower end surface of the sequencing chip 20 is supported on the lower limit plate 105, and its upper end surface abuts against the upper limit plate 104, thereby achieving the upper and lower position fixation of the sequencing chip 20. It should be noted that the upper and lower limiting plates 105 can be plates that continuously extend along the inner side wall of the chip frame 10 , or can be multiple plates that are separated from each other and spaced apart, which is not specifically limited here.

[0136] The limiting bosses 103 are fixedly mounted on the inner sidewalls of the chip frame 10. Each inner sidewall of the chip frame 10 is provided with at least one limiting boss 103. The limiting bosses 103 have contact surfaces that come into contact with the sidewalls of the sequencing chip 20. The contact surfaces may be flat, curved, or spherical. During installation, the four sidewalls of the sequencing chip 20 are brought into contact with the contact surfaces of the limiting bosses 103, thereby achieving multi-point positioning of the sidewalls of the sequencing chip 20, thereby fixing its position in the front-to-back and left-to-right directions.

[0137] In this embodiment, the front-side limiting boss 103 is preferably an elastic boss 102, fixed to the inner wall of the chip frame 10 via an elastic sheet. This elastic sheet is generally parallel to the inner wall of the chip frame 10 and exerts an elastic force that presses toward the inside of the chip slot. The elastic boss 102 is fixed to the end of the elastic sheet. This arrangement provides a certain amount of interference when the elastic boss 102 is free. When the sequencing chip 20 is installed, the elastic force of the elastic boss 102 presses the sequencing chip 20 toward the side opposite the elastic boss 102, ensuring greater stability in the front-to-back direction of the sequencing chip 20. In addition, the chip frame has an elastic side located on the elastic boss 102. During installation, the elastic side of the chip frame 10 is pulled outward to create a clearance space. The rear side of the sequencing chip 20 is then inserted between the upper and lower limit plates 105 on the rear side, and the front side is then inserted between the upper and lower limit plates 105 on the front side through the clearance space.

[0138] In this embodiment, the left-side limiting boss 103 preferably has an inclined surface that slopes inward from top to bottom, with the lower end of the inclined surface transitionally connected to the contact surface on the limiting boss 103. After the sequencing chip 20 is inserted forward and backward, the sequencing chip 20 is pushed rightward while the left side is pressed downward along the inclined surface, thereby smoothly inserting the sequencing chip 20 into the chip slot and further improving the installation convenience of the sequencing chip 20. It should be noted that in this embodiment, the inclined surface can also achieve the same effect on the right-side limiting boss 103, and this is not specifically limited here.

[0139] In this embodiment, the sealing gasket 30 and the chip outer frame 10 are detachably connected. Specifically, a hook 101 is fixedly provided at the bottom of the chip outer frame 10, and a hanging hole 302 is provided on the sealing gasket 30 for the hook 101 to be inserted. The sealing gasket 30 is connected to the hook 101 at the bottom of the chip outer frame 10 through the hanging hole 302, thereby fixing the two.

[0140] In this embodiment, a second fixing mechanism is provided between the chip outer frame 10 and the chip platform 40. Through the provision of the second fixing mechanism, the chip outer frame 10 can be stably mounted on the chip platform 40, thereby improving the overall stability. Specifically, the second fixing mechanism includes at least one forward and backward positioning reference 401 (i.e., the first limiting member 121 in FIG. 1 ) and at least one left and right positioning reference 401 (i.e., the second limiting member 122 in FIG. 1 ) and a positioning element 402 (i.e., the execution structure 140 in FIG. 1 ). The positioning reference 401 is fixedly mounted on the chip platform 40. A limiting notch 107 corresponding to the positioning reference 401 is provided on the chip outer frame 10. When the chip outer frame 10 is installed, its limiting notch 107 is aligned with the positioning reference 401, and the positioning reference 401 is embedded in the limiting notch 107, thereby realizing the positioning between the chip outer frame 10 and the chip platform 40 on the horizontal plane. In order to further fix the chip outer frame 10, the positioning element 402 and the chip platform 40 can be connected in a sliding or pressing manner, and can be moved and switched between the retracted position and the positioning position. Taking the sliding connection of the positioning element 402 as an example, the positioning element 402 is slidably installed on the chip platform 40, and a positioning head 402a is provided on the positioning element 402. The positioning head 402a can be a plane, an arc surface or a spherical surface. When the positioning element 402 slides toward the inside of the chip slot, it can reach the positioning position, and when it slides outward, it can reach the retracted position. The outer wall of the chip outer frame 10 has a positioning groove 106 (that is, the groove body where the abutment surface 131 in Figure 1 is located) for the positioning head 402a to be inserted into. When the positioning element 402 slides to the positioning position, the positioning head 402a is inserted into the positioning groove 106, thereby further fixing the chip outer frame 10.

[0141] The chip frame assembly of the present application has a compact structure. The chip frame and the sequencing chip are fixed by a first fixing mechanism, thereby ensuring that the sequencing chip is well stabilized in all directions, such as up and down, left and right, and front and back, and ensuring the accuracy and clarity of the sequencing chip image acquisition. The chip frame and the chip platform are fixed to each other by a second fixing mechanism, thereby ensuring that the chip frame as a whole has strong stability.

[0142] The chip frame assembly of the present application provides upper and lower position limits for the sequencing chip by configuring the first fixing mechanism as an upper limit plate, a lower limit plate, and a limit boss, and fixing at least two pairs of upper and lower limit plates on the opposing inner walls of the chip frame. Furthermore, at least one limit boss with a contact surface is provided on each inner side wall of the chip frame to limit the side of the sequencing chip, ensuring that it is fixedly limited in the horizontal direction.

[0143] The chip frame assembly of the present application is configured as an elastic boss, and the elastic boss is fixed to the side wall of the chip frame via an elastic sheet. This allows the elastic boss to have a certain amount of interference in its free state. During installation, the sequencing chip is squeezed toward the side opposite the elastic boss under the elastic force of the elastic boss, ensuring that the sequencing chip is more stable in the front-to-back direction. In addition, the side of the chip frame located on the elastic boss is elastic. During installation, the elastic side of the chip frame is pulled outward to create a clearance space, allowing the rear side of the sequencing chip to be inserted between the upper and lower limit plates on the rear side. The front side of the sequencing chip is then inserted between the upper and lower limit plates on the front side through the clearance space, facilitating installation.

[0144] The chip frame assembly of this application features an inclined surface on the left-side retaining boss, which slopes inward from top to bottom. The lower end of the inclined surface transitions into contact with the contact surface on the retaining boss. Once the sequencing chip is inserted front-to-back, the chip is pushed rightward while the left side is pressed downward along the inclined surface, allowing it to be smoothly inserted into the chip slot, further enhancing the ease of installation.

[0145] The embodiment of the present application further provides a gene sequencer, which includes a chip platform for carrying a chip;

[0146] a first limiting structure, fixedly connected to the chip platform, for abutting against the chip to limit movement of the chip along a first direction and a second direction; wherein the first direction and the second direction are perpendicular to each other;

[0147] a chip outer frame, movably connected to the chip platform, the chip outer frame being provided with a chip slot, the chip being arranged in the chip slot to restrict the chip from moving in a direction opposite to the first direction and in a direction opposite to the second direction;

[0148] an execution structure, connected to the chip platform and abutting against the chip frame, for pushing the chip frame to move along the first direction and the second direction to abut against the chip;

[0149] A sealing gasket, detachably mounted on the bottom of the chip frame;

[0150] The chip is internally provided with a plurality of horizontally arranged and mutually parallel fluid grooves. The lower end surface of the chip is provided with fluid ports communicating with both ends of the fluid grooves. The sealing gasket is provided with a fluid circular hole, and the sealing block is provided with a flow channel opening. The fluid ports, the fluid circular hole, and the flow channel opening are sequentially connected. For details, please refer to the relevant descriptions in Figures 1 to 13 and will not be repeated here.

[0151] In one specific embodiment, the chip frame forms an abutment surface that is inclined from a direction opposite to the first direction toward a direction opposite to the second direction; the execution structure includes an abutment member and an elastic member; the elastic member is connected to the chip platform and the abutment member, and is used to push the abutment member to move; the abutment member abuts the abutment surface to push the chip frame in the first and second directions under the action of the elastic member. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0152] In a specific embodiment, the abutment member is rotatably connected to the chip platform, and the rotation axis of the abutment member is parallel to the second direction. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0153] In a specific embodiment, one end of the elastic member is fixedly connected to the chip platform, and the other end of the elastic member is fixedly connected to one end of the abutment member. The elastic member is used to push the abutment member to rotate toward the chip frame. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0154] In one specific embodiment, a pressing portion is formed on the abutment member, the pressing portion being disposed on a side of the abutment member facing away from the elastic member. The pressing portion is configured to receive an external force and rotate in a direction away from the chip frame under the action of the external force. For details, please refer to the relevant descriptions in Figures 1 to 13 and will not be repeated here.

[0155] In a specific embodiment, the first limiting structure includes: a first limiting member fixedly connected to the chip platform, configured to abut against the chip to limit movement of the chip along the first direction; and a second limiting member fixedly connected to the chip platform, configured to abut against the chip to limit movement of the chip along the second direction. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0156] In one specific embodiment, the chip frame is annular, with a cavity formed inside the chip frame for accommodating the chip. The chip frame has a first inner wall and a second inner wall. The first inner wall is used to abut the chip to restrict movement of the chip in a direction opposite to the first direction. The second inner wall is used to abut the chip to restrict movement of the chip in a direction opposite to the second direction. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0157] In a specific embodiment, the chip frame forms an opening, the opening is connected to the cavity, and the opening is used to accommodate the first limiter and the second limiter. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0158] In a specific embodiment, the device further comprises: a cover body rotatably connected to the chip platform, for pressing the chip when the cover body is close to the chip platform. Detailed descriptions can be made with reference to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0159] In one specific embodiment, at least two sets of pressure claw assemblies are symmetrically mounted on the lower surface of the cover, and when the cover is closed, the at least two sets of pressure claw assemblies abut against the chip to press and secure the chip. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0160] In a specific embodiment, the pressure claw assembly includes a pressure claw frame, a rotating shaft, and a pressure claw. The pressure claw frame is rotatably connected to the rotating shaft, and the pressure claw abuts between the pressure claw frame and the rotating shaft. The pressure claw is used to press the chip. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0161] In one specific embodiment, the pressure claw assembly further includes a spring, one end of the pressure claw being used to compress the chip, and the other end of the pressure claw being fixedly connected to the pressure claw frame via the spring. For details, please refer to the relevant descriptions in Figures 1 to 13 and will not be repeated here.

[0162] In a specific embodiment, the pressure claw assembly further includes a support member, the pressure claw is disposed between the support member and the rotating shaft, and the middle portion of the pressure claw abuts against the support member. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0163] In a specific embodiment, the contact point between the pressure claw and the support member has an arc-shaped convex surface, and the pressure claw can rotate along the arc-shaped convex surface to adapt to the angle of the chip. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0164] In a specific embodiment, a limiting groove is formed on the top of the pressing claw, and the rotating shaft passes through the limiting groove and is rotatably connected to the pressing claw frame. Detailed descriptions can be made with reference to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0165] In one specific embodiment, the chip slot is provided with a first fixing mechanism for securing the chip; the first fixing mechanism includes an upper limit plate and a lower limit plate, each of which has at least one pair, and the at least one pair of upper and lower limit plates are fixedly mounted on opposite inner walls of the chip frame, with the chip accommodated in a groove formed between the upper and lower limit plates. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0166] In one specific embodiment, the first fixing mechanism further includes a limiting boss fixedly mounted on the inner sidewall of the chip frame. Each inner sidewall of the chip frame is provided with at least one limiting boss, each having a contact surface that abuts against the sidewall of the chip. For details, please refer to the relevant descriptions in Figures 1 to 13 and will not be repeated here.

[0167] In a specific embodiment, the contact surface is a plane, a curved surface or a spherical surface. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0168] In one specific embodiment, the front-side limiting boss is an elastic boss that is fixedly mounted on the inner wall of the chip frame via an elastic sheet and has an elastic force that presses toward the inside of the chip slot. For details, please refer to the relevant descriptions in Figures 1 to 13 and will not be repeated here.

[0169] In a specific embodiment, the left-side limiting boss has an inclined surface that slopes inward from top to bottom, and the lower end of the inclined surface transitionally connects with the contact surface on the limiting boss. For details, please refer to the relevant descriptions in Figures 1 to 13, which will not be repeated here.

[0170] In the above technical solution, accurate fixation of the chip is achieved through the cooperation of the chip, the chip frame and the chip platform.

[0171] The foregoing description is merely a preferred embodiment of this application and is not intended to limit this application. Persons skilled in the art of gene sequencing will readily appreciate the various modifications and variations of this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application shall be included within the scope of protection of this application.

Claims

1. A chip positioning device for positioning a chip in a gene sequencer, characterized in that: include: A base, used for carrying the chip; A first limiting structure, fixedly connected to the base, used to abut against the chip to limit the chip from moving along a first direction and a second direction; wherein the first direction and the second direction are perpendicular to each other; a second limiting structure, movably connected to the base, and used to abut against the chip to limit the movement of the chip in a direction opposite to the first direction and in a direction opposite to the second direction; The execution structure is connected to the base and abuts against the second limiting structure, and is used to push the second limiting structure to move along the first direction and the second direction to abut against the chip.

2. The chip positioning device according to claim 1, characterized in that: The second limiting structure forms an abutting surface, and the abutting surface is inclined from a direction opposite to the first direction toward a direction opposite to the second direction; The execution structure includes an abutment member and an elastic member; the elastic member is connected to the base and the abutment member to push the abutment member to move; the abutment member abuts against the abutment surface to push the second limiting structure to move along the first direction and the second direction under the action of the elastic member.

3. The chip positioning device according to claim 2, characterized in that: The abutment member is rotatably connected to the base, and a rotation axis of the abutment member is parallel to the second direction.

4. The chip positioning device according to claim 3, characterized in that: One end of the elastic member is fixedly connected to the base, and the other end of the elastic member is fixedly connected to one end of the abutment member. The elastic member is used to push the abutment member to rotate toward a direction close to the second limiting structure.

5. The chip positioning device according to claim 4, characterized in that: A pressing portion is formed on the abutment member, and the pressing portion is arranged on a side of the abutment member away from the elastic member. The pressing portion is used to receive external force and rotate in a direction away from the second limiting structure under the action of the external force.

6. The chip positioning device according to claim 1, characterized in that: The first limiting structure includes: a first limiting member, fixedly connected to the base, and used to abut against the chip to limit the chip from moving along the first direction; The second limiting member is fixedly connected to the base and is used to abut against the chip to limit the movement of the chip along the second direction.

7. The chip positioning device according to claim 6, characterized in that: The second limiting structure is annular, and a cavity for accommodating the chip is formed inside the second limiting structure; the second limiting structure has a first inner wall and a second inner wall, the first inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the first direction; the second inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the second direction.

8. The chip positioning device according to claim 7, characterized in that: The second limiting structure forms an opening, the opening is connected to the cavity, and the opening is used to accommodate the first limiting member and the second limiting member.

9. The chip positioning device according to any one of claims 1 to 8, characterized in that: Also includes: The cover body is rotatably connected to the base and is used for pressing the chip when the cover body is close to the base.

10. The chip positioning device according to claim 9, characterized in that: At least two groups of pressing claw assemblies are symmetrically mounted on the lower surface of the cover body, and the at least two groups of pressing claw assemblies abut against the chip when the cover body is close to the base, so as to press and fix the chip.

11. The chip positioning device according to claim 10, characterized in that: The pressure claw assembly comprises a pressure claw frame, a rotating shaft and a pressure claw. The pressure claw frame is rotatably connected to the rotating shaft. The pressure claw abuts between the pressure claw frame and the rotating shaft. The pressure claw is used to press the chip.

12. The chip positioning device according to claim 11, characterized in that: The pressure claw assembly also includes a spring, one end of the pressure claw is used to press the chip, and the other end of the pressure claw is fixedly connected to the pressure claw frame through the spring.

13. The chip positioning device according to claim 12, characterized in that: The pressure claw assembly also includes a supporting member, the pressure claw is placed between the supporting member and the rotating shaft, and the middle part of the pressure claw abuts against the supporting member.

14. The chip positioning device according to claim 13, characterized in that: The contact point between the pressing claw and the supporting member has an arc-shaped convex surface, and the pressing claw can rotate along the arc-shaped convex surface to adapt to the angle of the chip.

15. The chip positioning device according to claim 14, characterized in that: A limiting groove is provided on the top of the pressing claw, and the rotating shaft passes through the limiting groove and is rotatably connected to the pressing claw frame.

16. The chip positioning device according to any one of claims 11 to 15, characterized in that: The contact surface between the pressing claw and the chip is a flexible structure, and the flexible structure is one of a rubber pad, a sponge pad and a polyurethane foam.

17. The chip positioning device according to claim 10, characterized in that: The chip is provided with a plurality of flow channels arranged along its length direction, and fluid ports along the thickness direction of the chip are respectively provided on both sides of the flow channels, and the fluid ports are communicated with the flow channel ports in the base.

18. A chip frame device for a gene sequencer, characterized in that: It comprises a chip outer frame, a chip and a sealing gasket, wherein the chip outer frame is provided with a chip slot, the chip is arranged in the chip slot, and the chip slot is provided with a first fixing mechanism for fixing the chip; The sealing gasket is detachably mounted on the bottom of the chip frame; The chip is provided with a plurality of transverse and mutually parallel fluid grooves inside, the lower end surface of the chip is provided with a fluid port connected with both ends of the fluid grooves, the sealing gasket is provided with a fluid circular hole, and the fluid port and the fluid circular hole are connected in sequence.

19. The chip frame device for a gene sequencer according to claim 18, characterized in that: The sealing gasket is provided with a plug-in groove for engaging with the plug-in boss of the gene sequencer.

20. The chip frame device for a gene sequencer according to claim 18, characterized in that: The first fixing mechanism includes an upper limit plate and a lower limit plate, and there are at least one pair of the upper limit plate and the lower limit plate respectively. The at least one pair of upper and lower limit plates are respectively fixedly installed on the inner walls on the opposite sides of the chip frame, and the chip is accommodated in a groove formed between the upper limit plate and the lower limit plate.

21. The chip frame device for a gene sequencer according to claim 20, characterized in that: The first fixing mechanism also includes a limiting boss, which is fixedly mounted on the inner side wall of the chip outer frame. Each inner side wall of the chip outer frame is provided with at least one limiting boss, and the limiting boss has a contact surface that conflicts with the side wall of the chip.

22. The chip frame device for a gene sequencer according to claim 21, characterized in that: The contact surface is a plane, a curved surface or a spherical surface.

23. The chip frame device for a gene sequencer according to claim 21, characterized in that: The limiting boss located at the front side is an elastic boss, which is fixedly mounted on the inner wall of the chip outer frame through an elastic sheet and has an elastic force for pressing toward the inner side of the chip slot.

24. The chip frame device for a gene sequencer according to claim 21, characterized in that: The limiting boss on the left side has an inclined surface which is inclined from top to bottom and inward, and the lower end of the inclined surface is transitionally connected to the contact surface on the limiting boss.

25. The chip frame device for a gene sequencer according to claim 18, characterized in that: A hook is fixedly arranged at the bottom of the chip outer frame, and a hanging hole for the hook to be inserted is opened on the sealing gasket. The sealing gasket is connected to the hook at the bottom of the chip outer frame through the hanging hole.

26. The chip frame device for a gene sequencer according to claim 18, characterized in that: The chip outer frame is provided with a limiting notch corresponding to the positioning reference on the gene sequencer, and the positioning reference is embedded in the limiting notch.

27. The chip frame device for a gene sequencer according to claim 26, characterized in that: The outer side wall of the chip frame is provided with a positioning groove for cooperating with the positioning element on the gene sequencer. When the positioning element is in the retracted position, the positioning element is separated from the positioning groove.

28. A gene sequencer, characterized in that: include: Chip platform, used to carry the chip; A first limiting structure, fixedly connected to the chip platform, used to abut against the chip to limit the movement of the chip along a first direction and a second direction; wherein the first direction and the second direction are perpendicular to each other; A chip outer frame, movably connected to the chip platform, the chip outer frame is provided with a chip slot, the chip is arranged in the chip slot, so as to limit the movement of the chip in a direction opposite to the first direction and a direction opposite to the second direction; An execution structure, connected to the chip platform and abutting against the chip outer frame, used for pushing the chip outer frame to move along the first direction and the second direction to abut against the chip; A sealing gasket, detachably mounted on the bottom of the chip frame; A sealing block corresponding to the position of the sealing pad is arranged on the chip platform; The chip is provided with a plurality of transverse and mutually parallel fluid grooves inside, the lower end surface of the chip is provided with a fluid port connected with the two ends of the fluid groove, the sealing gasket is provided with a fluid circular hole, the sealing block is provided with a flow channel opening, and the fluid port, the fluid circular hole and the flow channel opening are connected in sequence.

29. The gene sequencer according to claim 28, characterized in that: The chip frame forms a contact surface, and the contact surface is inclined from a direction opposite to the first direction toward a direction opposite to the second direction; The execution structure includes an abutment member and an elastic member; the elastic member is connected to the chip platform and the abutment member to push the abutment member to move; the abutment member abuts against the abutment surface to push the chip frame to move along the first direction and the second direction under the action of the elastic member.

30. The gene sequencer according to claim 29, characterized in that: The abutment member is rotatably connected to the chip platform, and a rotation axis of the abutment member is parallel to the second direction.

31. The gene sequencer according to claim 30, characterized in that: One end of the elastic member is fixedly connected to the chip platform, and the other end of the elastic member is fixedly connected to one end of the abutment member. The elastic member is used to push the abutment member to rotate toward a direction close to the chip outer frame.

32. The gene sequencer according to claim 31, characterized in that: A pressing portion is formed on the abutting member, and the pressing portion is arranged on a side of the abutting member away from the elastic member. The pressing portion is used to receive external force and rotate in a direction away from the chip frame under the action of the external force.

33. The gene sequencer according to claim 28, wherein: The first limiting structure comprises: A first limiting member, fixedly connected to the chip platform, and used to abut against the chip to limit the movement of the chip along the first direction; The second limiting member is fixedly connected to the chip platform and is used for abutting against the chip to limit the movement of the chip along the second direction.

34. The gene sequencer according to claim 33, wherein: The chip frame is annular, and a cavity for accommodating the chip is formed inside the chip frame; the chip frame has a first inner wall and a second inner wall, the first inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the first direction; the second inner wall is used to abut against the chip to limit the movement of the chip in the opposite direction of the second direction.

35. The gene sequencer according to claim 34, wherein: The chip frame forms an opening, the opening is connected to the cavity, and the opening is used to accommodate the first limiting member and the second limiting member.

36. The gene sequencer according to any one of claims 28 to 35, characterized in that: Also includes: The cover body is rotatably connected to the chip platform and is used for pressing the chip when the cover body is close to the chip platform.

37. The gene sequencer according to claim 36, wherein: At least two groups of pressing claw assemblies are symmetrically installed on the lower surface of the cover body, and the at least two groups of pressing claw assemblies are in contact with the chip when the cover body is close to the chip platform, so as to press and fix the chip.

38. The gene sequencer according to claim 37, wherein: The pressure claw assembly comprises a pressure claw frame, a rotating shaft and a pressure claw. The pressure claw frame is rotatably connected to the rotating shaft. The pressure claw abuts between the pressure claw frame and the rotating shaft. The pressure claw is used to press the chip.

39. The gene sequencer according to claim 38, wherein: The pressure claw assembly also includes a spring, one end of the pressure claw is used to press the chip, and the other end of the pressure claw is fixedly connected to the pressure claw frame through the spring.

40. The gene sequencer according to claim 39, wherein: The pressure claw assembly also includes a supporting member, the pressure claw is placed between the supporting member and the rotating shaft, and the middle part of the pressure claw abuts against the supporting member.

41. The gene sequencer according to claim 40, characterized in that: The contact point between the pressing claw and the supporting member has an arc-shaped convex surface, and the pressing claw can rotate along the arc-shaped convex surface to adapt to the angle of the chip.

42. The gene sequencer according to claim 41, wherein: A limiting groove is provided on the top of the pressing claw, and the rotating shaft passes through the limiting groove and is rotatably connected to the pressing claw frame.

43. The gene sequencer according to any one of claims 28 to 42, characterized in that: The chip slot is provided with a first fixing mechanism for fixing the chip; the first fixing mechanism includes an upper limit plate and a lower limit plate, and the upper limit plate and the lower limit plate are at least one pair respectively, and the at least one pair of upper and lower limit plates are respectively fixedly installed on the inner walls on the opposite sides of the chip frame, and the chip is accommodated in the groove formed between the upper limit plate and the lower limit plate.

44. The gene sequencer according to claim 43, wherein: The first fixing mechanism also includes a limiting boss, which is fixedly mounted on the inner side wall of the chip outer frame. Each inner side wall of the chip outer frame is provided with at least one limiting boss, and the limiting boss has a contact surface that conflicts with the side wall of the chip.

45. The gene sequencer according to claim 44, characterized in that: The contact surface is a plane, a curved surface or a spherical surface.

46. ​​The gene sequencer according to claim 44, wherein: The limiting boss located at the front side is an elastic boss, which is fixedly mounted on the inner wall of the chip outer frame through an elastic sheet and has an elastic force for pressing toward the inner side of the chip slot.

47. The gene sequencer according to claim 44, wherein: The limiting boss on the left side has an inclined surface which is inclined from top to bottom and inward, and the lower end of the inclined surface is transitionally connected to the contact surface on the limiting boss.

48. The gene sequencer according to claim 28, wherein: A hook is fixedly arranged at the bottom of the chip outer frame, and a hanging hole for the hook to be inserted is opened on the sealing gasket. The sealing gasket is connected to the hook at the bottom of the chip outer frame through the hanging hole.

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