Insecticidal mixtures of pyriproxyfen

Abstract

The invention relates to a novel ternary insecticidal combination comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor competitive (nAChR) modulator.

Description

[0001] Title: Insecticidal mixtures of pyriproxyfen

[0002] TECHNICAL FIELD OF THE INVENTION

[0003] The invention relates to a novel ternary insecticidal combination comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor competitive (nAChR) modulator.

[0004] BACKGROUND OF THE INVENTION

[0005] Stink bugs (Hemiptera: Pentatomidae) are insect pests which cause serious damage to many agricultural crops by using their sharp mouthparts to pierce and suck plant parts, especially in crops such as soybean, corn, cotton, and tomato. The stink bug populations in Brazil have become increasingly dispersed and hard to control, causing severe economic losses to growers across the country.

[0006] The most abundant species of stink bugs in nature include Euschistus (brown stink bugs), Dichelops (green-belly stink bugs), Nezara viridula (southern green stink bug) and Piezodorus guildinii (redbanded stink bug).

[0007] The stink bug life cycle consists of three stages - egg, nymph and adult. The eggs hatch into the nymph stage. These immature nymphs have the same color and shape as the adults but are much smaller. To grow larger, each nymph must shed its outer covering in order to make room for their larger body. This process is known as "molting." Stink bug nymphs molt as many as five times before they reach adulthood. Each period of the molting process is called an "instar".

[0008] Sting bugs are challenging insect to manage since both nymphs and adults damage crops. Moreover, the adults have a tough exoskeleton covered with a waxy, water-repellant cuticle that can help protect them from pesticide applications and enable them to easily invade previously treated areas. Theoretically adults can fly more than 70 miles per day and the nymphs, which are wingless, are relatively mobile due to strong walking capacity (Wiman et al. 2014; Lee and Leskey 2015). Neonicotinoids (IRAC sub-group 4A), organophosphates (IRAC sub-group IB), carbamates (IRAC sub-group 1A) and pyrethroids (IRAC sub-group 3A) insecticides currently represent the main control strategy for this pest; sometimes sub-group 4A and 3A are mixed in order to enhance control efficacy and / or sub-groups IB, 4A and 3A are rotated as a part of a program designed to prevent resistance development. Each of these chemical groups is characterized by a different mode of action within the insect however, they all act on the insect central nervous system.

[0009] Currently there are few effective insecticides that are labeled for use against Stink bugs therefore, additional products which achieve effective control are needed.

[0010] SUMMARY OF THE INVENTION

[0011] The invention relates to a novel ternary insecticidal combination comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor competitive (nAChR) modulator.

[0012] The present invention also relates to a method for control of insects, comprising contacting the insects or their food supply, habitat, breeding grounds or their locus with (i) an amount of pyriproxyfen, and (ii) an amount of pyrethroid and (iii) an amount of nAChR competitive modulator.

[0013] DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

[0014] Definitions

[0015] Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by persons of ordinary skill in the art to which this subject matter belongs.

[0016] As used herein, the term "combination" means an assemblage of agrochemicals for application either by simultaneous or contemporaneous application.

[0017] As used herein, the term "simultaneous" when used in connection with application of agrochemicals means that the agrochemicals are applied in an admixture, for example, a tank mix. For simultaneous application, the combination may be the admixture or separate containers each containing an agrochemical that are combined prior to application. As used herein, the term "contemporaneous" when used in connection with application of agrochemicals means that an individual agrochemical is applied separately from another agrochemical or premixture at the same time or at times sufficiently close together that an activity that is additive or more than additive or synergistic relative to the activity of either agrochemical alone at the same dose is achieved.

[0018] As used herein, the term "mixture" refers to, but is not limited to, a combination in any physical form, e.g., blend, solution, suspension, dispersion, emulsion, alloy, or the like.

[0019] As used herein, the term "tank mix" means one or more of the components of the combination, mixture or composition of the present invention are added are mixed in a spray tank at the time of spray application or prior to spray application.

[0020] As used herein, the term "composition" includes at least one of the combinations or mixtures of the present invention with agriculturally acceptable carrier.

[0021] As used herein, the term "effective" when used in connection with an amount of the active ingredient, combination, mixture or composition refers to an amount of the active ingredient, combination, mixture or composition that achieve an agriculturally beneficial level of control of the insect when applied to a plant, propagation material of the plant, soil or a locus.

[0022] As used herein, the term "insecticidally effective amount" refers to an amount of the active component that is commercially recommended for use to control insects. The commercially recommended amount for each active component, often specified as application rates of the commercial formulation, may be found on the label accompanying the commercial formulation. The commercially recommended application rates of the commercial formulation may vary depending on factors such as the plant species and the insects to be controlled.

[0023] As used herein, the term "effective" when used in connection with a method for treating a plant or locus against insecticidal infestation means that the method provides an agriculturally beneficial level of treatment without significantly interfering with the normal growth and development of the plant. As used herein, the term "treating a plant or locus against insecticidal infestation" includes, but is not limited to, protecting the plant or locus against insecticidal infestation and / or controlling insecticidal infestation of the plant or locus.

[0024] As used herein, the term "controlling insecticidal infestation of the plant or locus" includes, but is not limited to, controlling insect population infecting the plant or locus, controlling a plant or soil disease caused by insects, controlling insect attack on the plant or locus, reducing insecticidal infestation of the plant or locus, and / or curing plant or soil disease caused by insects / insecticidal infestation.

[0025] As used herein, the term "more effective for protecting the plant or locus against insecticidal infestation" includes, but is not limited to, prolonging the duration of protection against insecticidal infestation after application and extending the protection period against insecticidal infestation.

[0026] As used herein, the term "more effective for controlling insecticidal infestation" includes, but is not limited to, increasing efficacy of insect control, and reducing the amount of time needed to achieve a given level of insecticidal control.

[0027] As used herein, the term "agriculturally acceptable carrier" means carriers which are known and accepted in the art for the formation of compositions for agricultural or horticultural use.

[0028] As used herein, the term "adjuvant" is broadly defined as any substance that itself is not an active ingredient, but which enhances or is intended to enhance the effectiveness of the insecticide with which it is used. Adjuvants may be understood to include, spreading agents, penetrants, compatibility agents, and drift retardants.

[0029] As used herein, the term "agriculturally acceptable inert additives" is defined as any substance that itself is not an active ingredient but is added to the composition such as sticking agents, surfactants, synergists, buffers, acidifiers, anti-oxidation agent, defoaming agents and thickeners. As used herein, the term "plant" includes reference to the whole plant, plant organ (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, and propagation material of the plant. As used herein the term "plant" includes reference to agricultural crops include field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.) and fruits (peach, etc.).

[0030] As used herein the term "propagation material" is to be understood to denote all the generative parts of the plant such as seeds and spores, seedlings, and vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.

[0031] As used herein, the term "locus" includes not only areas where insecticidal infestation may already be shown, but also areas where insecticidal infestation has yet to show, and also to areas under cultivation. Locus includes, but is not limited to, soil and other plant growth medium.

[0032] As used herein the term "ha" refers to hectare.

[0033] As used herein, the term "excipient" refers to any chemical which has no significant pesticidal activity, such as surfactant(s), solvent(s), or adjuvant(s). One or more excipients can be added to any combination, mixture or composition disclosed herein.

[0034] The term "a" or "an" as used herein includes the singular and the plural, unless specifically stated otherwise. Therefore, the terms "a," "an," or "at least one" can be used interchangeably in this application.

[0035] Throughout the application, descriptions of various embodiments use the term "comprising"; however, it will be understood by one of skill in the art, that in some specific instances, an embodiment can be described using the language "consisting essentially of" or "consisting of."

[0036] The term "about" herein specifically includes ±10% from the indicated values in the range. In addition, the endpoints of all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges.

[0037] It is understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the invention as if the integers and tenths thereof are expressly described herein. For example, "5 g / ha to 120 g / ha" includes 5.0 g / ha, 5.1 g / ha, 5.2 g / ha, 5.3 g / ha, 5.4 g / ha, etc. up to 120 g / ha. It is understood that nAChR competitive modulator and nAChR modulator refer to "nicotinic acetylcholine receptor competitive (nAChR) modulator".

[0038] All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated herein by reference.

[0039] The following examples illustrate the practice of the present subject matter in some of its embodiments but should not be construed as limiting the scope of the present subject matter. Other embodiments apparent to persons of ordinary skill in the art from consideration of the specification and examples herein that fall within the spirit and scope of the appended claims are part of this invention. The specification, including the examples, is intended to be exemplary only, without limiting the scope and spirit of the invention.

[0040] Aspects and embodiments of the present invention will now be described.

[0041] The invention relates to a novel ternary insecticidal combination comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator.

[0042] It has been surprisingly found that by combining insecticides having two different modes of action (MOA), i.e., sodium channel modulators and nicotinic acetylcholine receptors (nAChR) competitive modulators with pyriproxyfen, insecticidal combinations are produced that exhibit high efficacy against stink bugs and provides control of its entire life cycle including the eggs, the nymphs, and the adults. It was even more surprising found that the combination according to the invention resulted in synergistic effect.

[0043] In some embodiments the combination is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone.

[0044] In some embodiments, the amount of pyriproxyfen and the amount of the nAChR modulator and the pyrethroid when applied together is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone. In some embodiments, the amount of the compound pyriproxyfen applied is less than the insecticidally effective amount of the compound pyriproxyfen when pyriproxyfen is used alone, and / or wherein the amount of the nAChR modulator applied is less than the insecticidally effective amount of the nAChR modulator when the nAChR modulator is used alone, and / or wherein the amount of the pyrethroid applied is less than the insecticidally effective amount of the pyrethroid when the pyrethroid is used alone.

[0045] In some embodiments, the amount of the compound pyriproxyfen improves the insecticidal efficacy of the amount of the pyrethroid, and the nicotinic acetylcholine receptor (nAChR) modulator insecticides compared to when the same amount of the pyrethroid, and the nicotinic acetylcholine receptor (nAChR) modulator insecticides are applied not in combination with the amount of the compound pyriproxyfen.

[0046] In some embodiments, insecticidal efficacy is increased by at least 10%, 20%, or 30%. In some embodiments, insecticidal efficacy is increased by at least 50%, 100%, 200% or 300%.

[0047] In some embodiments, insecticidal efficacy is measured in a treated area of the plant. In some embodiments, insecticidal efficacy is measured in an untreated area of the plant. In some embodiments, insecticidal efficacy is increased in a treated area of the plant. In some embodiments, insecticidal efficacy is increased in an untreated area of the plant.

[0048] In some embodiments, insecticidal efficacy is measure at least 5 days after treatment. In some embodiments, insecticidal efficacy is measure at least 8 days after treatment. In some embodiments, insecticidal efficacy is measure at least 10 days after treatment. In some embodiments, insecticidal efficacy is measure at least 14 days after treatment. In some embodiments, insecticidal efficacy is measure at least 21 days after treatment.

[0049] In some embodiments, a substantially similar level of insecticidal efficacy is achieved by using a lesser amount of the compound pyriproxyfen and / or the pyrethroid, and / or the nicotinic acetylcholine receptor (nAChR) modulator.

[0050] In some embodiments, the amount of the compound pyriproxyfen in the combination is less than the insecticidally effective amount of the compound pyriproxyfen when used alone. In some embodiments, the amount of the compound pyriproxyfen is less than its insecticidally effective amount. In some embodiments, the amount of the pyrethroid in the combination is less than the insecticidally effective amount of the pyrethroid when used alone. In some embodiments, the amount of the nicotinic acetylcholine receptor (nAChR) modulator in the combination is less than the insecticidally effective amount of the nicotinic acetylcholine receptor (nAChR) modulator when used alone. In some embodiments, the amount of the pyrethroid, the amount of the nicotinic acetylcholine receptor (nAChR) modulator and the amount of the compound pyriproxyfen are more effective for treating a plant or locus against insecticidal infestation than when the amount of the compound pyriproxyfen and the amount of the pyrethroid and the amount of the nicotinic acetylcholine receptor (nAChR) modulator are applied alone. In some embodiments, the combination of the compound pyriproxyfen, the pyrethroid and the nicotinic acetylcholine receptor (nAChR) modulator applied is more effective in treating the plant or soil against insecticidal infestation than when each insecticide at the same amount is applied alone.

[0051] In some embodiments, treating the plant or locus against insecticidal infestation comprises protecting the plant or locus from insecticidal attack.

[0052] In some embodiments, treating the plant or locus against insecticidal infestation comprises controlling all the life cycle of the insect including the eggs, the nymphs and adults.

[0053] In some embodiments, the combination reduces the amount of time needed to achieve a level of insecticidal control than when the amount of the compound of pyriproxyfen and the amount of the pyrethroid and the amount of the nicotinic acetylcholine receptor (nAChR) modulator are applied alone.

[0054] An example for reduction is, if each insecticide is applied alone achieves 50% control of insecticidal infestation 10 days after application, the mixture or composition disclosed herein achieves 50% control of insecticidal infestation 5 days after application where each insecticide is applied at the amount.

[0055] In some embodiments, the amount of time needed to achieve a level of insecticidal control is reduced by at least 1 day, 2 days, 3 days, 4 day, 5 days, 7 days, 10 days, 14 days or 16 days.

[0056] In some embodiments, the combination improves plant development compared to the development of a plant affected by the same type and degree of insecticidal infestation to which the combination is not applied. In some embodiments, the plant is a crop plant. In some embodiments, the pyrethroid as part of the combination is more effective in improving plant development than when applied at the same amount alone. In some embodiments, the compound pyriproxyfen as part of the combination is more effective in improving plant development than when applied at the same amount alone. In some embodiments, the nAChR modulator as part of the combination is more effective in improving plant development than when applied at the same amount alone.

[0057] In some embodiments, the plant development is improved by treating the plant against insecticidal infestation.

[0058] In some embodiments, improving plant development comprises enhancing crop plants. In some embodiment, improving plant development comprises improving plant quality.

[0059] Improving plant development includes, but is not limited to, enhancing plant vigor, enhancing greening effect on leaves and / or enhancing plant potential yield.

[0060] In some embodiments, improving plant development comprises enhancing plant vigor. In some embodiments, plant vigor is assessed using the relative vigor index. In some embodiments, plant vigor is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0061] In some embodiments, improving plant development comprises enhancing greening effect on leaves. In some embodiments, greening effect on leaves is assessed using the relative vigor index. In some embodiments, greening effect on leaves is increased by at least 1%, 5%, or 10%.

[0062] In some embodiments, improving plant development comprises enhancing plant yield. In some embodiments, plant yield is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0063] In some embodiments, the present invention provides a synergistic insecticidal combination, comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator.

[0064] In some embodiments, the pyrethroid is selected from allethrin, bifenthrin, cyfluthrin, beta- cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin and transfluthrin. In some embodiments, the pyrethroid is selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate.

[0065] In some embodiments, the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyradifurone, triflumezopyrim, dicloromezotiaz, flupyrimin and sulfoxaflor. In some embodiments, the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0066] In some embodiments, the pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate and the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0067] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is sulfoxaflor.

[0068] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is thiamethoxam.

[0069] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is midacloprid.

[0070] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is acetamiprid.

[0071] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0072] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0073] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0074] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20. In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0075] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0076] In some embodiments, the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0077] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:200 to 200:1.

[0078] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:200 to 200:1.

[0079] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:200 to 200:1.

[0080] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:100 to 100:1.

[0081] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:100 to 100:1.

[0082] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:100 to 100:1.

[0083] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:50 to 50:1.

[0084] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:50 to 50:1.

[0085] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:50 to 50:1.

[0086] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:20 to 20:1. In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:20 to 20:1.

[0087] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:20 to 20:1.

[0088] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:10 to 10:1.

[0089] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:10 to 10:1.

[0090] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:10 to 10:1.

[0091] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:10 to 5:1.

[0092] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:10 to 5:1.

[0093] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:10 to 10:1.

[0094] In some embodiments, the weight ratio between pyriproxyfen and the pyrethroid is from about 1:7 to 3:1.

[0095] In some embodiments, the weight ratio between pyriproxyfen and the nAChR modulator is from about 1:7 to 3:1.

[0096] In some embodiments, the weight ratio between the pyrethroid and the nAChR modulator is from about 1:7 to 7:1.

[0097] In some embodiments, the combination has a synergistic effect in treating a plant or a locus against insecticidal infestation.

[0098] In some embodiments, the insecticidal infestation is of an insect from the family of Pentatomidae. In some embodiments, the insecticidal infestation is of from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0099] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0100] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects from the family of Pentatomidae.

[0101] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0102] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200. In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0103] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0104] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0105] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0106] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0107] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200 is for controlling insects from the family of Pentatomidae.

[0108] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100 is for controlling insects from the family of Pentatomidae.

[0109] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50 is for controlling insects from the family of Pentatomidae. In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20 is for controlling insects from the family of Pentatomidae.

[0110] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10 is for controlling insects from the family of Pentatomidae.

[0111] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10 is for controlling insects from the family of Pentatomidae.

[0112] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7 is for controlling insects from the family of Pentatomidae.

[0113] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0114] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0115] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0116] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0117] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0118] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0119] In some embodiments, the synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau- fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor is for controlling insects selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0120] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam.

[0121] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-200: 1-200: 1-200.

[0122] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-100: 1-100: 1-100.

[0123] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-50: 1-50: 1-50.

[0124] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-20: 1-20: 1-20.

[0125] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-10: 1-10: 1-10.

[0126] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-5: 1-10: 1-10.

[0127] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-3: 1-7: 1-7.

[0128] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam.

[0129] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-200: 1-200: 1-200.

[0130] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-100: 1-100: 1-100.

[0131] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-50: 1-50: 1-50. In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-20: 1-20: 1-20.

[0132] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-10: 1-10: 1-10.

[0133] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-5: 1-10: 1-10.

[0134] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of thiamethoxam wherein the weight ratio between pyriproxyfen, bifenthrin and thiamethoxam is within the range of about 1-3: 1-7: 1-7.

[0135] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor.

[0136] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 200: 1-200: 1-200.

[0137] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 100: 1-100: 1-100.

[0138] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 50: 1-50: 1-50.

[0139] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 20: 1-20: 1-20.

[0140] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 10: 1-10: 1-10.

[0141] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 5: 1-10: 1-10.

[0142] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of sulfoxaflor wherein the weight ratio between pyriproxyfen, bifenthrin and sulfoxaflor is within the range of about 1- 3: 1-7: 1-7.

[0143] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid.

[0144] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-200: 1-200: 1-200.

[0145] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-100: 1-100: 1-100. In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-50: 1-50: 1-50.

[0146] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-20: 1-20: 1-20.

[0147] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-10: 1-10: 1-10.

[0148] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-5: 1-10: 1-10.

[0149] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of imidacloprid wherein the weight ratio between pyriproxyfen, bifenthrin and imidacloprid is within the range of about 1-3: 1-7: 1-7.

[0150] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid.

[0151] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-200: 1-200: 1-200.

[0152] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-100: 1-100: 1-100.

[0153] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-50: 1-50: 1-50.

[0154] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-20: 1-20: 1-20.

[0155] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-10: 1-10: 1-10.

[0156] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-5: 1-10: 1-10.

[0157] In some embodiments, synergistic insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of bifenthrin, and (iii) an amount of acetamiprid wherein the weight ratio between pyriproxyfen, bifenthrin and acetamiprid is within the range of about 1-3: 1-7: 1-7.

[0158] In some embodiments, the combination is a mixture.

[0159] In some embodiments, the mixture is a tank mix.

[0160] The invention further relates to a composition comprising the combination disclosed herein.

[0161] In some embodiments, the composition comprises pyriproxyfen in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition, and / or pyrethroid in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition, and / or an nAChR modulator in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition.

[0162] In some embodiments, the composition comprises pyriproxyfen in an amount ranging from about 0.1% to 30% by weight based on the total weight of the composition, and / or pyrethroid in an amount ranging from about 0.1% to 30% by weight based on the total weight of the composition, and / or an nAChR modulator in an amount ranging from about 0.1% to 30% by weight based on the total weight of the composition.

[0163] In some embodiments, the amount of pyriproxyfen in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5% to about 90%, 93%, 95%, 98% or 99% by weight based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.

[0164] In some embodiments, the amount of the pyrethroid in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5% to about 90%, 93%, 95%, 98%, or 99% by weight based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.

[0165] In some embodiments, the amount of the nAChR modulator in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5% to about 90%, 93%, 95%, 98%, or 99% by weight based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.

[0166] In some embodiments, the composition further comprising an agricultural acceptable additive.

[0167] In some embodiments, the agricultural acceptable additive is selected from surfactants, dispersants, emulsifiers, rheology modifiers, pH modifiers, thickeners, adjuvants and carriers.

[0168] In some embodiments, the composition further comprising at least one pesticide.

[0169] In some embodiments, the composition is formulated for dilution in water before application.

[0170] In some embodiments, the combination, mixture or composition are listed in table 1: Table 1.

[0171]

[0172] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1- 200: 1-200: 1-200.

[0173] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:200 to 200:1.

[0174] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:200 to 200:1.

[0175] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:200 to 200:1.

[0176] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1- 100: 1-100: 1-100.

[0177] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:100 to 100:1.

[0178] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:100 to 100:1. In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:100 to 100:1.

[0179] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1-50: 1-50: 1-50.

[0180] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:50 to 50:1.

[0181] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:50 to 50:1.

[0182] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:50 to 50:1.

[0183] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1-20: 1-20: 1-20.

[0184] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:20 to 20:1.

[0185] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:20 to 20:1.

[0186] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:20 to 20:1.

[0187] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1-10: 1-10: 1-10.

[0188] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:10 to 10:1.

[0189] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:10 to 10:1. In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:10 to 10:1.

[0190] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1-5: 1-10: 1-10.

[0191] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:10 to 5:1.

[0192] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:10 to 5:1.

[0193] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:10 to 10:1.

[0194] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1-3: 1-7: 1-7.

[0195] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid in the combination, mixture or composition lies within the ranges of about 1:7 to 3:1.

[0196] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:7 to 3:1.

[0197] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator in the combination, mixture or composition lies within the ranges of about 1:7 to 7:1.

[0198] In some embodiments, the combination, mixture or composition is synergistic. In some embodiments, the combination, mixture or composition has synergistic effect in treating a plant or locus against insecticidal infestation.

[0199] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1- 200: 1-200: 1-200.

[0200] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:200 to 200:1. In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:200 to 200:1.

[0201] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:200 to 200:1.

[0202] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1- 100: 1-100: 1-100.

[0203] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:100 to 100:1.

[0204] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:100 to 100:1.

[0205] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:100 to 100:1.

[0206] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1-50: 1-50: 1-50.

[0207] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:50 to 50:1.

[0208] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:50 to 50:1.

[0209] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:50 to 50:1.

[0210] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1-20: 1-20: 1-20.

[0211] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:20 to 20:1. In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:20 to 20:1.

[0212] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:20 to 20:1.

[0213] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1-10: 1-10: 1-10.

[0214] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 10:1.

[0215] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 10:1.

[0216] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 10:1.

[0217] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1-5: 1-10: 1-10.

[0218] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 5:1.

[0219] In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 5:1.

[0220] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:10 to 10:1.

[0221] In some embodiments, the weight ratio of pyriproxyfen, the pyrethroid and the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1-3: 1-7: 1-7.

[0222] In some embodiments, the weight ratio of pyriproxyfen to the pyrethroid at which the insecticidal effect is synergistic lies within the ranges of about 1:7 to 3:1. In some embodiments, the weight ratio of pyriproxyfen to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:7 to 3:1.

[0223] In some embodiments, the weight ratio of the pyrethroid to the nAChR modulator at which the insecticidal effect is synergistic lies within the ranges of about 1:7 to 7:1.

[0224] In some embodiments, the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0225] In some embodiments, the locus is a crop field.

[0226] In some embodiments, the crop filed is selected from Apples, Apricots, Asian pears, Cherries, Corn (field and sweet), Grapes, Beans, Nectarines and Peaches, Peppers, Tomatoes, Soybean, Cotton, Rice and Winter cereals (such as wheat).

[0227] In some embodiments, the invention relates to the use of the combination, mixture or composition disclosed herein for treating a plant or a locus against insecticidal infestation.

[0228] The invention further relates to a method for control of insects, comprising contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination, mixture or composition disclosed herein.

[0229] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator.

[0230] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied at the time of planting.

[0231] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied 1 to 60 day(s) after planting.

[0232] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied 1 to 9 month(s) after planting.

[0233] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied once during a growth season. In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied at least one time during a growth season.

[0234] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied two or more times during a growth season.

[0235] In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied as a soil application. In some embodiments, pyriproxyfen the pyrethroid and the nAChR modulator are applied as a foliar application.

[0236] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0237] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0238] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0239] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0240] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0241] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0242] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0243] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator.

[0244] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0245] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0246] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0247] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0248] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0249] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0250] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0251] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0252] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0253] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0254] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0255] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0256] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0257] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0258] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0259] In some embodiments, the said pyrethroid is selected allethrin, bifenthrin, cyfluthrin, beta- cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin and transfluthrin. In some embodiments, the said pyrethroid is selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate.

[0260] In some embodiments, the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyradifurone, triflumezopyrim, dicloromezotiaz, flupyrimin and sulfoxaflor. In some embodiments, the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0261] In some embodiments, the pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate and the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor. In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0262] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0263] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0264] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0265] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0266] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10.

[0267] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10. In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0268] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

[0269] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0270] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0271] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

[0272] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20.

[0273] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10. In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10.

[0274] In some embodiments, the method for control of insects from the family of Pentatomidae, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha- cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0275] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0276] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

[0277] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100.

[0278] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1- 50: 1-50.

[0279] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1- 20: 1-20.

[0280] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1- 10: 1-10.

[0281] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1- 10: 1-10.

[0282] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus) and the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7.

[0283] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200 is for controlling insects from the family of Pentatomidae.

[0284] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-100: 1-100: 1-100 is for controlling insects from the family of Pentatomidae.

[0285] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50 is for controlling insects from the family of Pentatomidae.

[0286] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-20: 1-20: 1-20 is for controlling insects from the family of Pentatomidae.

[0287] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-10: 1-10: 1-10 is for controlling insects from the family of Pentatomidae.

[0288] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-5: 1-10: 1-10 is for controlling insects from the family of Pentatomidae.

[0289] In some embodiments, the method for control of insects, comprises contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination insecticidal combination comprising combination comprising (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid selected from bifenthrin, alpha-cypermethrin, beta- cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate, and (iii) an amount of nicotinic acetylcholine receptor (nAChR) modulator selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-3: 1-7: 1-7 is for controlling insects from the family of Pentatomidae.

[0290] In some embodiments, the present invention provides a method for control of insects, comprising contacting the insects or their food supply, habitat, breeding grounds or their locus with (i) an amount of pyriproxyfen, and (ii) an amount of a pyrethroid and (iii) an amount of an nAChR modulator. In some embodiments, the method is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone.

[0291] In some embodiments, the amount of pyriproxyfen and the amount of nAChR modulator and pyrethroid when applied together is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone.

[0292] In some embodiments, the amount of the compound pyriproxyfen applied is less than the insecticidally effective amount of the compound pyriproxyfen when pyriproxyfen is used alone, and / or wherein the amount of the nAChR modulator applied is less than the insecticidally effective amount of the nAChR modulator when the nAChR modulator is used alone, and / or wherein the amount of the pyrethroid applied is less than the insecticidally effective amount of the pyrethroid when the pyrethroid is used alone.

[0293] In some embodiments, the method is effective for controlling insecticidal infestation.

[0294] In some embodiments, the method is effective for controlling the entire life cycle of the insect.

[0295] In some embodiments, the method is effective for protecting the plant or locus from insecticidal infestation.

[0296] In some embodiments, the life cycle includes the eggs, the nymphs and the adults.

[0297] In some embodiments, pyriproxyfen is applied at an amount from 7.5 g / ha to 37.5 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0298] In some embodiments, the pyrethroid is applied at an amount from 25 g / ha to 75 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0299] In some embodiments, the nAChR modulator is applied at an amount from 10 g / ha to 50 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0300] When pyriproxyfen the pyrethroid and the nAChR modulator are applied in the form of the combinations, mixtures or compositions disclosed herein, the rate at which the combinations, mixture and / or composition is applied will depend upon the particular type of insect to be controlled, the degree of control required and the timing and method of application. In general, the combinations, mixtures or compositions described herein can be applied at an application rate of between about 42.5 gram per hectare (g / ha) and about 162.5 g / ha.

[0301] The combinations, mixtures or compositions disclosed herein can be applied at an application rate of between about 42.5 g / ha and about 162.5 g / ha based on the total amount of active ingredients.

[0302] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is sulfoxaflor.

[0303] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is thiamethoxam.

[0304] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is imidacloprid.

[0305] In some embodiments, the pyrethroid is bifenthrin and the nAChR modulator is acetamiprid.

[0306] In some embodiments, pyriproxyfen, the pyrethroid and the nAChR modulator are applied simultaneously or contemporaneously.

[0307] In some embodiments, pyriproxyfen, the pyrethroid and the nAChR modulator are applied separately or together.

[0308] In some embodiments, the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

[0309] In some embodiments, the locus is a crop field.

[0310] In some embodiments, the crop filed is selected from Apples, Apricots, Asian pears, Cherries, Corn (field and sweet), Grapes, Beans, Nectarines and Peaches, Peppers, Tomatoes, Soybean, Cotton, Rice and Winter cereals (such as wheat).

[0311] The present invention also relates to the use of the combination, mixture or composition disclosed herein for treating a plant or a locus against insecticidal infestation. In some embodiments, the treatment is effective for the entire life cycle of the insect.

[0312] In some embodiments, the life cycle includes the eggs, the nymphs and the adults.

[0313] In some embodiments, the combination, mixture or composition disclosed herein are for the use to treat a plant or a locus against insecticidal infestation.

[0314] A synergistic effect exists wherever the action of a combination of active components is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount (or an effective amount of a synergistic composition or combination) is an amount that exhibits greater insecticidal activity than the sum of the insecticidal activities of the individual components.

[0315] The following examples illustrate the practice of the present invention in some of its embodiments but should not be construed as limiting the scope of the invention. Other embodiments will be apparent to one skilled in the art from consideration of the specification and examples. It is intended that the specification, including the examples, is considered exemplary only without limiting the scope and spirit of the invention.

[0316] BIOLOGICAL EXAMPLES

[0317] ABBOTT formula was used to assess the % efficacy relative to the untreated control. The formula of ABBOTT (1925) was used: % efficacy = (T-t)*100 / T, where "T" is the number of live stinkbugs in the control, and "t" is the live stinkbugs in the treatments. The treatments were submitted to analysis of variance and the means were compared by the Scott-Knott test at 5% significance through the RStudio program present within the ARM® system of GDM Solutions.

[0318] A synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components.

[0319] In the field of agriculture, it is often understood that the term "synergy" is as defined by Colby S. R. in an article entitled "Calculation of the synergistic and antagonistic responses of herbicide combinations" published in the journal Weeds, 1967, 15, p. 20-22. The action expected for a given combination of two active components can be calculated as follows: The action expected for a given combination of three active components can be calculated as follows:

[0320] XY+XZ+YZ XYZ

[0321] E = X+Y+Z - - + -

[0322] 100 10000 in which E represents the expected percentage of insecticidal control for the combination of the three insecticides at defined doses (for example equal to x, y and z respectively), X is the percentage of insecticidal control observed by the compound (I) at a defined dose (equal to x) , Y is the percentage of insecticidal control observed by the compound (II) at a defined dose (equal to y) , Z is the percentage of insecticidal control observed by the compound (III) at a defined dose (equal to z). When the percentage of insecticidal control observed for the combination is greater than the expected percentage, there is a synergistic effect.

[0323] Experiments were carried out to determine the synergistic insecticidal effect of the ternary insecticidal composition which comprises a mixture of pyriproxyfen, a pyrethroid compound and an nAChR competitive modulator compound.

[0324] Combinations of pyriproxyfen, bifenthrin and sulfoxaflor:

[0325] Two Laboratory trials were conducted to evaluate the insecticidal control of brown stink bug (Euschistus heros) with pyriproxyfen, bifenthrin and sulfoxaflor, alone and in ternary mixture. The ternary mixture prepared by combining commercially available compositions of 25 g.ai / ha of pyriproxyfen (Tiger 100 EC), 16 g.ai / ha of bifenthrin (Seizer 100 EC) and 96 g.ai / ha of sulfoxaflor (Closer 240 SC). The products / mixtures were diluted with water to the stated relative field dose rates of the active compound. Experiment design was in random blocks with six repetitions. The spray volume of application was equivalent to 150 L / ha in both trials.

[0326] Example 1. Combinations of pyriproxyfen, pyrethroid and nicotinic acetylcholine receptor (nAChR) competitive modulator for control of adult brown stink bug in soybean.

[0327] To establish the type of interactions existing between pyriproxyfen, pyrethroid and nicotinic acetylcholine receptor (nAChR) competitive modulator in an in vitro efficacy evaluation assay, and their efficacy against adult brown stink bug was tested.

[0328] The number of dead adults was assessed 1-day post-application (DAA). Table 2. Control of adult brown stink bugs (Euschistus heros) in soybean

[0329] The number of dead nymphs was assessed 1-day post-application (DAA).

[0330] The expected percent of control was determined using the method of Colby S. R. as discussed above, and the Colby ratio (observed average / expected average) was calculated. When the percentage of insecticidal control observed for the combination is greater than the expected percentage (i.e., the Colby ratio is greater than 1), there is a synergistic effect.

[0331] Example 2. Combinations of pyriproxyfen, pyrethroid and nicotinic acetylcholine receptor (nAChR) competitive modulator for control of brown stink bug nymph in soybean.

[0332] To establish the type of interactions existing between pyriproxyfen, pyrethroid and nicotinic acetylcholine receptor (nAChR) competitive modulator in an in vitro efficacy evaluation assay, and their efficacy against brown stink bug nymphs was tested.

[0333] Table 3. Control of brown stink bug (Euschistus heros) nymphs in soybean

[0334] The expected percent of control was determined using the method of Colby S. R. as discussed above, and the Colby ratio (observed average / expected average) was calculated. When the percentage of insecticidal control observed for the combination is greater than the expected percentage (i.e., the Colby ratio is greater than 1), there is a synergistic effect.

[0335] Based on the results presented hereinabove, the ternary insecticidal composition which comprises a combination of pyriproxyfen, a pyrethroid and a nicotinic acetylcholine receptor (nAChR) competitive modulator was found to exhibit strong synergistic effects against brown stink bug from the family of Pentatomidae. Such combinations are suitable for controlling of said insects in a plant or in the environment in which such a plant is grown or stored, such as soil, storage containers, etc.

[0336] Example 3. Combinations of pyriproxyfen, pyrethroid and nicotinic acetylcholine receptor (nAChR) competitive modulator for control of brown stink bug nymphs and adults in soybean.

[0337] Laboratory trials were conducted to evaluate the insecticidal control of brown stink bug (Euschistus heros) with pyriproxyfen, bifenthrin and sulfoxaflor, alone, binary, and ternary mixtures. Two ternary mixture prepared by combining commercially available compositions of 0.5 g.ai / ha of pyriproxyfen (Tiger 100 EC), 0.85 g.ai / ha of bifenthrin (Seizer 100 EC) and 0.6 g.ai / ha of sulfoxaflor (Closer 240 SC) and of 1 g.ai / ha of pyriproxyfen (Tiger 100 EC), 1.7 g.ai / ha of bifenthrin (Seizer 100 EC) and 1.2 g.ai / ha of sulfoxaflor (Closer 240 SC). The ternary mixtures were diluted with water to prepare the spray solution diluted relative to field dose rates of the active compounds. The lower ratio was tested on adults and the higher ratio was tested on nymphs.

[0338] The experiments were designed to evaluate the synergy of Sulfoxaflor + Bifenthrin + Pyriproxyfen on Nymphs and Adults of Brown Stink Bug (Euschistus heros). The experimental design used in the trials was of split-blocks with 6 replications, conducted in laboratory conditions. Each experimental unit was a plastic box called gerbox with dimensions of 11cm x 11cm x 3,5cm. To carry out the sprays, a pressurized CO2 backpack sprayer was used. The constant working pressure was 40 PSI, and the spray volume was 150 L / ha-1. The sprayer was equipped with a 1,5-meter boom containing three spray nozzles (110.015), spaced 50 cm apart. The sprays were carried out in the gerbox beforehand, and after spraying, 10 stink bugs were released per experimental unit, one experiment was conducted with nymphs, and the other was conducted with adult stink bugs.

[0339] Variables and Evaluation Methodologies:

[0340] Count of living insects: The count of the remaining living stink bugs was made at 4 hours, 6 hours after the spray.

[0341] Table 4. Observed control of brown stink bug (Euschistus heros) nymphs.

[0342] *Means followed by the same letters do not differ significantly from each other by the Scott-Knott test at a 5% significance level.

[0343] Table 5. Expected control of brown stink bug (Euschistus heros) nymphs.

[0344]

[0345] Table 6. Observed / expected calculation - brown stink bug (Euschistus heros) nymphs.

[0346] Table 7. Observed control of brown stink bug (Euschistus heros) adults.

[0347]

[0348] *Means followed by the same letters do not differ significantly from each other by the Scott-Knott test at a 5% significance level.

[0349] Table 8. Expected control of brown stink bug (Euschistus heros) adults.

[0350] Table 9. Observed / expected calculation - brown stink bug (Euschistus heros) adults.

[0351]

[0352] Combinations of pyriproxyfen, bifenthrin and acetamiprid:

[0353] Laboratory trials were conducted to evaluate the insecticidal control of brown stink bug (Euschistus heros) with pyriproxyfen, bifenthrin and acetamiprid, alone, binary, and ternary mixtures. The ternary mixture prepared by combining commercially available compositions of 0.6 g.ai / ha of pyriproxyfen (Tiger 100 EC), 1.5 g.ai / ha of bifenthrin (Seizer 100 EC) and 2 g.ai / ha of acetamiprid (Mospilan 725 WG) which than was diluted with water to prepare the spray solution diluted relative to field dose rates of the active compound and tested on nymphs.

[0354] The experiments were designed to evaluate the level of the synergy of Acetamiprid + Bifenthrin + Pyriproxyfen on Nymphs of Brown Stink Bug (Euschistus heros). The experimental design used in the trials was of split-blocks with 6 replications, conducted in laboratory conditions. Each experimental unit was a plastic box called gerbox with dimensions of 11cm x 11cm x 3,5cm.

[0355] To carry out the sprays, a pressurized CO2 backpack sprayer was used. The constant working pressure was 40 PSI, and the spray volume was 150 L / ha-1. The sprayer was equipped with a 1,5-meter boom containing three spray nozzles (110.015), spaced 50 cm apart. The sprays were carried out in the gerbox beforehand, and after spraying, 10 stink bugs were released per experimental unit.

[0356] Variables and Evaluation Methodologies:

[0357] Count of living insects: The count of the remaining living stink bugs was made at 4 hours, 6 hours and 1 day after the spray. Table 10. Observed control of bifenthrin + acetamiprid + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

[0358] *Means followed by the same letters do not differ significantly from each other by the Scott-Knott test at a 5% significance level.

[0359] Table 11. Expected control of bifenthrin + acetamiprid + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

[0360] Table 12. Observed / expected calculation - bifenthrin + acetamiprid + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

[0361] Combinations of pyriproxyfen, bifenthrin and dinotefuran:

[0362] Laboratory trials were conducted to evaluate the insecticidal control of brown stink bug (Euschistus heros) with pyriproxyfen, bifenthrin and dinotefuran, alone, binary, and ternary mixtures. The ternary mixture prepared by combining commercially available compositions of 0.6 g.ai / ha of pyriproxyfen (Tiger 100 EC), 1.5 g.ai / ha of bifenthrin (Seizer 100 EC) and 2 g.ai / ha of dinotefuran (Dinno 200 SG) which than was diluted with water to prepare the spray solution diluted relative to field dose rates of the active compound and tested on nymphs.

[0363] The experiments were designed to evaluate the level of the synergy of Bifenthrin + Dinotefuran + Pyriproxyfen on Nymphs of Brown Stink Bug (Euschistus heros). The experimental design used in the trials was of split-blocks with 6 replications, conducted in laboratory conditions. Each experimental unit was a plastic box called gerbox with dimensions of 11cm x 11cm x 3,5cm. To carry out the sprays, a pressurized CO2 backpack sprayer was used. The constant working pressure was 40 PSI, and the spray volume was 150 L / ha-1. The sprayer was equipped with a 1,5-meter boom containing three spray nozzles (110.015), spaced 50 cm apart. The sprays were carried out in the gerbox beforehand, and after spraying, 10 stink bugs were released per experimental unit.

[0364] Variables and Evaluation Methodologies:

[0365] Count of living insects: The count of the remaining living stink bugs was made at 4 hours and 6 hours after the spray.

[0366] Table 13. Observed control of bifenthrin + dinotefuran + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

[0367] *Means followed by the same letters do not differ significantly from each other by the Scott-Knott test at a 5% significance level.

[0368] Table 14. Expected control of bifenthrin + dinotefuran + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

[0369]

[0370] Table 15. Observed / expected calculation - bifenthrin + dinotefuran + pyriproxyfen on brown stink bug (Euschistus heros) nymphs.

Claims

Claims:

1. An insecticidal combination comprising: (i) an amount of pyriproxyfen, (ii) an amount of pyrethroid, and (iii) an amount of nicotinic acetylcholine receptor competitive (nAChR) modulator.

2. The combination of claim 1, wherein: a) the combination is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone, b) the amount of pyriproxyfen and the amount of nAChR modulator and pyrethroid when applied together is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone, and / or c) the amount of the compound pyriproxyfen applied is less than the insecticida lly effective amount of the compound pyriproxyfen when pyriproxyfen is used alone, and / or wherein the amount of the nAChR modulator applied is less than the insecticidally effective amount of the nAChR modulator when the nAChR modulator is used alone, and / or wherein the amount of the pyrethroid applied is less than the insecticidally effective amount of the pyrethroid when the pyrethroid is used alone.

3. The combination according to claim 1 or 2, wherein the pyrethroid is selected from allethrin, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin and transfluthrin.

4. The combination according to claim 3, wherein said pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda- cyhalothrin, cypermethrin and tau-fluvalinate.

5. The combination according to claim 1 or 2, wherein the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyradifurone, triflumezopyrim, dicloromezotiaz, flupyrimin and sulfoxaflor.

6. The combination according to claim 5, wherein the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

7. The combination according to any one of claims 1-6, wherein the pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta- cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate and the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

8. The combination according to claim 7, wherein the pyrethroid is bifenthrin and the nAChR modulator is sulfoxaflor.

9. The combination according to claim 7, wherein the pyrethroid is bifenthrin and the nAChR modulator is thiamethoxam.

10. The combination according to claim 7, wherein the pyrethroid is bifenthrin and the nAChR modulator is imidacloprid.

11. The combination according to claim 7, wherein the pyrethroid is bifenthrin and the nAChR modulator is acetamiprid.

12. The combination according to any one of claims 1-11, wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-200: 1-200: 1-200.

13. The combination according to claim 12, wherein the weight ratio between pyriproxyfen, the pyrethroid and the nAChR modulator is within the range of about 1-50: 1-50: 1-50.

14. The combination according to any one of claims 1-13, wherein the combination has a synergistic effect in treating a plant or a locus against insecticidal infestation.

15. A mixture comprising the combination of any one of claims 1-14.

16. The mixture of claim 15, wherein the mixture is a tank mix.

17. A composition comprising the combination according to any one of claims 1-14.

18. The composition according to claim 17, wherein: a) the composition comprises pyriproxyfen in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition, and / or b) the composition comprises a pyrethroid in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition, and / orc) the composition comprises an nAChR modulator in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition.

19. The composition according to claim 17 or 18, further comprising an agricultural acceptable additive.

20. The composition according to claim 19, wherein the agricultural acceptable additive is selected from surfactants, dispersants, emulsifiers, rheology modifiers, pH modifiers, thickeners, adjuvants and carriers.

21. A method for control of insects, comprising contacting the insects or their food supply, habitat, breeding grounds or their locus with the combination, mixture or composition according to any one of claims 1-20.

22. A method for control of insects, comprising contacting the insects or their food supply, habitat, breeding grounds or their locus with (i) an amount of pyriproxyfen, and (ii) an amount of a pyrethroid and (iii) an amount of an nAChR modulator.

23. The method according to claim 21 or 22, wherein: a) the method is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone, b) the amount of pyriproxyfen and the amount of nAChR modulator and pyrethroid when applied together is more effective in treating a plant or locus against insecticidal infestation than when each insecticide at the same amount is applied alone, and / or, c) the amount of the compound pyriproxyfen applied is less than the insecticida lly effective amount of the compound pyriproxyfen when pyriproxyfen is used alone, and / or wherein the amount of the nAChR modulator applied is less than the insecticidally effective amount of the nAChR modulator when the nAChR modulator is used alone, and / or wherein the amount of the pyrethroid applied is less than the insecticidally effective amount of the pyrethroid when the pyrethroid is used alone. d) the method is effective for controlling insecticidal infestation and / or e) the method is effective for controlling the entire life cycle of the insect and / or f) the method is effective for protecting the plant or locus from insecticidal infestation.

24. The method according to claim 23, wherein the life cycle includes the eggs, the nymphs and the adults.

25. The method according to any one of claims 21-24, wherein pyriproxyfen is applied at an amount from 7.5 g / ha to 37.5 g / ha.

26. The method according to any one of claims 21-25, wherein the pyrethroid is applied at an amount from 25 g / ha to 75g / ha.

27. The method according to any one of claims 21-26, wherein the nAChR modulator is applied at an amount from 10 g / ha to 50 g / ha.

28. The method according to any one of claims 22-27, wherein the said pyrethroid is selected allethrin, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin and transfluthrin.

29. The method according to claim 28, wherein said pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda- cyhalothrin, cypermethrin and tau-fluvalinate.

30. The method according to any one of claims 22-27, wherein the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyradifurone, triflumezopyrim, dicloromezotiaz, flupyrimin and sulfoxaflor.

31. The method according to claim 30, wherein the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

32. The method according to any one of claims 22-31, wherein the pyrethroid is selected from bifenthrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, lambda-cyhalothrin, cypermethrin and tau-fluvalinate and the nAChR modulator is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam and sulfoxaflor.

33. The method according to claim 32, wherein the pyrethroid is bifenthrin and the nAChR modulator is sulfoxaflor.

34. The method according to claim 32, wherein the pyrethroid is bifenthrin and the nAChR modulator is thiamethoxam.

35. The method according to claim 32, wherein the pyrethroid is bifenthrin and the nAChR modulator is imidacloprid.

36. The method according to claim 32, wherein the pyrethroid is bifenthrin and the nAChR modulator is acetamiprid.

37. The method according to any one of claims 21-36, wherein pyriproxyfen, the pyrethroid and the nAChR modulator are applied simultaneously or contemporaneously.

38. The method according to any one of claims 21-36, wherein pyriproxyfen, the pyrethroid and the nAChR modulator are applied separately or together.

39. The method according to any one of claims 21-38, wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

40. The method according to any one of claims 21-39, wherein the locus is a crop field.

41. The method according to claim 40, wherein the crop filed is selected from Apples, Apricots, Asian pears, Cherries, Corn (field and sweet), Grapes, Beans, Nectarines and Peaches, Peppers, Tomatoes, Soybean, Cotton, Rice and Winter cereals (such as wheat).

42. Use of the combination, mixture or composition according to any one of claims 1-20 for treating a plant or a locus against insecticidal infestation.

43. The use according to claim 42, wherein the treatment is effective for the entire life cycle of the insect.

44. The use according to claim 43, wherein the life cycle includes the eggs, the nymphs and the adults.

45. The use according to any one of claims 42-44, wherein the insects are selected from Brown stink bug (Euschistus heros), Small stink bug (Piezodorus guildinii), Southern green stink bug (Nezara viridula) and Green belly stink bug (Diceraeus furcatus, Diceraeus melacanthus).

46. The use according to any one of claims 42-45, wherein the locus is a crop field.

47. The use according to claim 46, wherein the crop field is selected from Apples, Apricots, Asian pears, Cherries, Corn (field and sweet), Grapes, Beans, Nectarines and Peaches, Peppers, Tomatoes, Soybean, Cotton, Rice and Winter cereals (such as wheat).

48. The combination, mixture, or composition of any one of claims 1-20 for the use to treat a plant or a locus against insecticidal infestation.

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