Dosing device capable of setting and dialing back dose

Abstract

A dosing device capable of setting and dialing back dose, comprising a cartridge holder (2), wherein a rear end of the cartridge holder (2) is connected to a housing (6), a push rod (8) is mounted in the housing (6), and the push rod (8) is configured to move on the basis of a set dose to deliver medicines during injection; a rotor (4), which is in threaded connection with the push rod (8) and is configured to rotationally drive the push rod (8) to axially move forwards during injection; a rotating shaft (9), wherein a front end of the rotating shaft is connected to the interior of a rear end of the rotor (4), and the rotating shaft is configured to drive the rotor (4) to rotate during injection, can axially move relative to the rotor (4), and can cooperate with the push rod (8) to control setting of a final dose during an axial moving process; a differential nut (10), which is mounted on an outer side of the rear end of the rotating shaft (9) and configured to perform differential adjustment and drive the rotating shaft (9) to move axially; a differential screw (7), which is fixed in the housing (6), is arranged between the differential nut (10) and a dose setting rotary drum (11), and is in threaded connection with both the differential nut (10) and the dose setting rotary drum (11); the dose setting rotary drum (11), which can be engaged with a bushing (12) and drive the bushing (12) to rotate during injection, and is configured to drive the differential nut (10) to rotate synchronously; and the bushing (12), which is connected to an inner side of the rear end of the rotating shaft (9) and configured to drive the rotating shaft (9) to rotate during injection.

Description

Drug delivery device with adjustable and reversible doses Technical Field

[0001] The present invention belongs to the technical field of drug delivery devices, and in particular relates to a drug delivery device capable of setting and recalling dosage. Background Art

[0002] With the development of insulin injection pen technology, the current requirements for insulin injection pens include: (1) multiple small-dose injections, generally reaching the maximum single injection dose (60 IU) of no less than 5 injections; (2) convenient adjustment of the single injection dose, with an adjustment range of 0-60 IU and high adjustment accuracy (up to 1 IU); (3) when adjusting the dose, the scale can be visually observed, or the injection pen can make a sound, so that patients with poor vision or even blindness can operate it themselves; (4) during injection, the operation is simple, and the injection pen will also make a sound during the injection process to indicate that the injection process is in progress.

[0003] Existing CN 103170038 A discloses an insulin injection pen, comprising a pen cap, a needle, an injection tube with a built-in piston and pre-loaded with medication, an injection sleeve, a positioning block, a screw, a nut tube, a fixing tube, a coil, and a button. The screw has two parallel sections cut off along the axial direction. The front end of the screw is a pressure head, which couples to the internal threads of the nut tube. The injection pen also includes a rotating handle and a return spring. The rotating handle is located at the outer end of the injection pen, opposite the pen cap. The outer end of the coil is disposed within and fixed to the rotating handle. The other end of the coil is engaged with the nut tube. The positioning block is sleeved outside the coil and is engaged with the coil. The nut tube is disposed between the pressure head and the positioning block. The return spring is sleeved on the coil, with one end of the return spring fixed to the inner side of the rotating handle and the other end fixed to the positioning block. The present invention enables multiple uses and precisely controlled insulin injections through repeated adjustment of the positioning block, the return spring, and the clutch spring. Although the insulin injection pen can accurately control the dosage, its adjustment and control structure is relatively complex, and it cannot implement callback dosage and cannot prevent sub-dose injection.

[0004] Summary of the Invention

[0005] In view of the problems existing in the above background technology, the purpose of the present invention is to provide a settable and reversible dose drug delivery device with a simple and reasonable structure, which can adjust the dose and prevent sub-dose injection.

[0006] The technical solution adopted in the present invention is:

[0007] The drug delivery device can set and call back the dosage, comprising a cartridge holder, a detachable pen cap at the front end of the cartridge holder, a cartridge bottle installed in the cartridge holder, a shell connected to the rear end of the cartridge holder, and a cartridge installed in the shell.

[0008] The plunger is used to deliver the drug after moving according to the set dose during injection;

[0009] The rotor is threadedly connected to the push rod and is used to rotate and drive the push rod to move axially forward during injection, and can cooperate with the housing to produce injection sound;

[0010] The rotating shaft, whose front end is connected to the rear end of the rotor, is used to drive the rotor to rotate during injection. It can also move axially relative to the rotor, and can cooperate with the push rod to control the final dose setting during the axial movement;

[0011] The differential nut is installed on the outer side of the rear end of the rotating shaft and is used for differential adjustment and driving the rotating shaft to move axially;

[0012] A differential screw is fixed in the housing and is disposed between the differential nut and the dose setting drum. The differential screw is threadedly connected to the differential nut and the dose setting drum for differential adjustment, and is rotationally connected to the rotor and axially constrains the rotor.

[0013] The dose setting drum is used to drive the bushing to move axially when setting the dose and cooperate with the bushing to make the dose setting sound. During injection, it can engage with the bushing and drive the bushing to rotate. It is also used to drive the differential nut to rotate synchronously;

[0014] A bushing connected to the inner side of the rear end of the rotating shaft and used to drive the rotating shaft to rotate during injection;

[0015] An injection button is installed in the rear end of the dose setting drum, which can apply force to drive the dose setting drum to rotate counterclockwise and drive the bushing to rotate synchronously after engaging with the dose setting drum.

[0016] Furthermore, the outer surface of the rotor is provided with a protruding one-way ratchet, and the inner ring of the shell is evenly distributed with notches, and the one-way ratchet cooperates with the notches to produce injection sound during the rotation process.

[0017] Furthermore, the dose setting cylinder and the bushing are both provided with meshing teeth in the axial direction, and when the dose setting cylinder rotates, the meshing teeth on the dose setting cylinder and the meshing teeth on the bushing slide and cooperate with each other to produce a dose setting sound.

[0018] Furthermore, the rotor and the rotating shaft, the rotating shaft and the bushing, and the differential nut and the dose setting drum are all connected via axial grooves.

[0019] Furthermore, the rotating shaft and the differential nut, and the rotor and the differential screw are all connected in a circumferential ring.

[0020] Furthermore, a flange is provided at the rear end of the push rod, and a step is provided inside the front end of the rotating shaft, and the flange and the step can contact and limit the final dose setting.

[0021] Furthermore, the push rod is a screw rod.

[0022] Furthermore, a push plate for cooperating with the piston of the cartridge bottle is installed at the front end of the push rod.

[0023] Furthermore, the push rod and the push plate are an integral structure, and a radially penetrating through groove is provided at the front end thereof to facilitate deformation and assembly during assembly.

[0024] Furthermore, a reset spring is provided between the injection button and the bushing.

[0025] Compared with the prior art, the present invention has the following significant advantages:

[0026] 1. The rotating shaft can cooperate with the push rod to control the final dose setting during axial movement to prevent sub-dose injection;

[0027] 2. The dosage setting and callback process, as well as the injection process, are achieved through the coordination of the dosage setting drum, differential screw, differential nut, rotating shaft, bushing, and rotor, with a simple and reasonable structure.

[0028] 3. The rotor and the housing cooperate to make a sound to remind the user of the injection dosage;

[0029] 4. The dose setting drum and the bushing cooperate to make a sound to remind the user to set the dose. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] FIG1 is a schematic diagram of the appearance structure of the present invention.

[0031] FIG2 is a schematic diagram of the explosion structure of the present invention.

[0032] FIG3 is a schematic cross-sectional view of the present invention.

[0033] FIG4 is a schematic diagram of the structure of the dosage setting of the present invention.

[0034] FIG5 is a schematic structural diagram of the injection process of the present invention.

[0035] FIG6 is a schematic structural diagram of the final dose setting control of the present invention.

[0036] FIG7 is a schematic structural diagram of the present invention after use.

[0037] FIG8 is a schematic structural diagram of the rotor and housing of the present invention cooperating to produce sound.

[0038] FIG. 9 is a schematic diagram of the axial groove connection structure between the differential nut and the dose setting drum of the present invention.

[0039] FIG10 is a schematic diagram of a second structure of the push rod of the present invention.

[0040] In the figure: 1-pen cap; 2-pen refill holder; 3-cartridge; 4-rotor; 41-one-way ratchet; 42-annular groove; 5-push plate; 6-housing; 61-notch; 7-differential screw; 71-annular rib; 8-push rod; 81-flange; 82-through groove; 9-rotating shaft; 91-step; 10-differential nut; 101-rib; 11-dose setting drum; 111-long strip groove; 12-bushing; 13-injection button; 14-spring; 15-meshing tooth. DETAILED DESCRIPTION

[0041] The present invention will be further described below with reference to specific embodiments, but the present invention is not limited to these specific embodiments. Those skilled in the art should recognize that the present invention covers all possible alternatives, improvements and equivalents within the scope of the claims.

[0042] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "clockwise", "counterclockwise" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more, unless otherwise clearly defined.

[0043] In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "connect," "fixed," etc. should be understood broadly. For example, they may refer to fixed, detachable, or integral connections; mechanical or electrical connections; direct or indirect connections through an intermediary; or internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0044] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Furthermore, a first feature being "above," "above," and "above" a second feature may include the first feature being directly above or obliquely above the second feature, or may simply mean that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may include the first feature being directly below or obliquely below the second feature, or may simply mean that the first feature is lower in level than the second feature.

[0045] Example 1

[0046] 1-9, this embodiment provides a drug delivery device capable of setting and recalling a dose, comprising a cartridge holder 2, a detachable cap 1 provided at the front end of the cartridge holder 2, a cartridge bottle 3 installed in the cartridge holder 2, a housing 6 connected to the rear end of the cartridge holder 2, and a cartridge 3 installed in the housing 6.

[0047] The push rod 8 is a screw structure, which is used to move according to the set dose during injection and deliver the drug; the front end of the push rod 8 is equipped with a push plate 5 for cooperating with the piston of the cartridge 3;

[0048] The rotor 4 is threadedly connected to the push rod 8 and is used to rotate and drive the push rod 8 to move axially forward during injection, and can cooperate with the housing 6 to produce injection sound;

[0049] The front end of the rotating shaft 9 is connected to the rear end of the rotor 4 and is used to drive the rotor 4 to rotate during injection. The rotating shaft 9 can also move axially relative to the rotor 4. During the axial movement, it can cooperate with the push rod 8 to control the final dose setting;

[0050] The differential nut 10 is installed on the outer side of the rear end of the rotating shaft 9 and is used for differential adjustment and driving the rotating shaft 9 to move axially;

[0051] A differential screw 7 is fixed within the housing 6 and disposed between the differential nut 10 and the dose setting drum 11. It is threadedly connected to both the differential nut 10 and the dose setting drum 11 for differential speed adjustment. The differential screw 7 is rotationally connected to the rotor 4 and axially constrains the rotor 4 so that it cannot move axially and can only rotate radially. The pitches of the internal and external threads of the differential screw 7 are different, thereby achieving differential speed adjustment.

[0052] The dose setting drum 11 is used to drive the bushing 12 to move axially when setting the dose and cooperate with the bushing 12 to make the dose setting sound. During injection, it can engage with the bushing 12 and drive the bushing 12 to rotate. At the same time, it is used to drive the differential nut 10 to rotate synchronously;

[0053] The bushing 12 is connected to the inner side of the rear end of the rotating shaft 9 and is used to drive the rotating shaft 9 to rotate during injection;

[0054] An injection button 13 is installed in the rear end of the dose setting drum 11, which can apply force to drive the dose setting drum 11 to rotate counterclockwise and drive the bushing 12 to rotate synchronously after engaging with the dose setting drum 11. A reset spring 14 is provided between the injection button 13 and the bushing 12.

[0055] In this embodiment, the rotor 4 is equipped with protruding one-way ratchet teeth 41 on its outer surface, and the housing 6 is evenly distributed within its inner periphery. The one-way ratchet teeth 41 cooperate with the notches 61 during rotation to produce an injection sound. The one-way ratchet teeth 41 restrict the rotor 4 to counterclockwise rotation. A beep can be set to sound for each unit of rotation to remind the user of the injection dose. Specifically, the housing 6 is provided with 24 notches 61, and the one-way ratchet teeth 41 are symmetrically arranged on the outer surface of the rotor 4. The beep sounds once every 15 degrees of rotation of the rotor 4.

[0056] In this embodiment, the dose setting barrel 11 and the sleeve 12 are each axially provided with meshing teeth 15. When the dose setting barrel 11 rotates, the meshing teeth 15 on the dose setting barrel 11 and the meshing teeth 15 on the sleeve 12 slide together, producing a dose setting sound. The meshing teeth 15 on the dose setting barrel 11 and the meshing teeth 15 on the sleeve 12 abut axially, and when the dose setting barrel 11 rotates, the tooth surfaces directly collide with each other, generating vibration and sound.

[0057] In this embodiment, the rotor 4 and rotating shaft 9, the rotating shaft 9 and bushing 12, and the differential nut 10 and dose setting drum 11 are all connected by axial grooves to achieve synchronous rotation. Taking the axial groove connection between the differential nut 10 and the dose setting drum 11 as an example, the outer surface of the differential nut 10 is provided with axially protruding ribs 101 or ribbed platforms, and the inner wall of the dose setting drum 11 is provided with axially elongated grooves 111. The ribs 101 and the elongated grooves 111 are connected in a mating axial groove connection.

[0058] In this embodiment, the rotating shaft 9 and differential nut 10, as well as the rotor 4 and differential screw 7, are both connected by a circumferential ring. Taking the rotor 4 and differential screw 7 as an example, the outer surface of the rotor 4 is provided with an annular groove 42, and the inner surface of the differential screw 7 is provided with a protruding annular rib 71 or a ring step. The annular groove 42 and the annular rib 71 cooperate to form a circumferential ring connection. The circumferential ring connection between the rotor 4 and the differential screw 7 restricts the axial movement of the rotor 4, while the rotor 4 can rotate relative to the differential screw 7. The circumferential ring connection between the rotating shaft 9 and the differential nut 10 allows the differential nut 10 to drive the rotating shaft 9 to move axially, allowing the rotating shaft 9 and the differential nut 10 to rotate relative to each other.

[0059] In this embodiment, the rear end of the push rod 8 is provided with a flange 81, and the front end of the rotating shaft 9 is provided with a step 91. The flange 81 and the step 91 can contact each other to limit and control the final dose setting.

[0060] To set a dose in the present invention, the dose setting drum 11 is rotated clockwise. Due to the axial groove connecting the dose setting drum 11 and the differential nut 10, the differential nut 10 rotates synchronously clockwise with the dose setting drum 11. The differential nut 10 is threadedly connected to the axially and circumferentially fixed differential screw 7, which is located outside the differential nut 10. Consequently, during this rotation, the differential nut 10 rotates clockwise along the threaded track of the differential screw 7, producing axial displacement toward the proximal end. A circumferential ring connection is provided between the differential nut 10 and the rotating shaft 9, enabling the rotating shaft 9 to move axially toward the proximal end. The rotor 4 and the rotating shaft 9, as well as the rotating shaft 9 and the bushing 12, are all connected by axial grooves. The rotor 4 is always axially limited and configured to rotate only in one direction, counterclockwise. Therefore, when setting a dose, the rotor 4 does not rotate and restricts the rotating shaft 9 so that it cannot rotate. The rotating shaft 9 in turn restricts the bushing 12 so that it cannot rotate. Due to the abutment relationship between the dose setting drum 11 and the bushing 12 at its proximal end, the bushing 12 can only follow the dose setting sleeve 11 in axial displacement toward the proximal end. During this period, the abutment between the dose setting drum 11 and the bushing 12 causes vibration and sound due to one tooth surface sliding across the other tooth surface, thereby achieving the dose setting sound.

[0061] During the callback process of the present invention, the callback process is the opposite of the dose setting process. When the dose setting drum 11 is rotated counterclockwise, the differential nut 10 rotates synchronously with the dose setting drum 11 counterclockwise, rotating counterclockwise along the threaded track of the differential screw 7 and generating axial displacement distally, thereby achieving callback. During the callback process, the rotating shaft 9 follows the differential nut 10 in distal axial movement, while the bushing 12, restrained by the injection button 13 and spring 14, follows the dose setting sleeve 11 in distal axial displacement. During this process, the abutment between the dose setting drum 11 and the bushing 12 generates vibration and sound due to the sliding of one tooth surface against the other, which triggers the dose callback sound.

[0062] During an injection, the injection button 13 is pressed, applying force to the dose setting drum 11. Simultaneously, the teeth of the dose setting drum 11 mesh with the teeth of the bushing 12, causing the dose setting drum 11 to rotate counterclockwise distally. The differential nut 10, connected to its axial groove, also rotates counterclockwise distally, synchronously with the bushing 12. The bushing 12 drives the rotating shaft 9 counterclockwise, which in turn drives the rotor 4 counterclockwise, which in turn drives the push rod 8 linearly distally, thereby achieving the injection. Each rotation of the rotor 4 produces a beep. Because the differential nut 10 and the rotating shaft 9 are connected by a circumferential ring, the differential nut 10 can drive the rotating shaft 9 distally during the injection process.

[0063] When controlling the final dose setting in the present invention, the dose setting drum 11 is rotated clockwise. The synchronously rotating differential nut 10 drives the rotating shaft 9 to axially displace proximally. When the step 91 within the rotating shaft 9 abuts the flange 8 of the push rod 8, the rotating shaft 9 is unable to move further proximally. Because the rotating shaft 9 and the differential nut 10 are connected by a circumferential ring, the rotating shaft 9 is unable to move proximally. Consequently, the differential nut 10 is also unable to move proximally. Furthermore, the differential nut 10 is connected to the dose setting sleeve 11 by an axial groove, and thus the dose setting sleeve 11 is also unable to rotate clockwise. At this point, if the dose setting cannot reach the predetermined dose by further rotating the dose setting sleeve 11, the dose setting is unsuccessful and the pen user is clearly informed of this. This effectively controls the final dose and prevents sub-dose injections.

[0064] The rotating shaft 9 of the present invention can cooperate with the push rod 8 to control the final dose setting during the axial movement to prevent sub-dose injection; the dose setting and callback processes, as well as the injection process, are realized through the cooperation of the components among the dose setting drum 11, the differential screw 7, the differential nut 10, the rotating shaft 9, the bushing 12, and the rotor 4, and the structure is simple and reasonable; the rotor 4 cooperates with the housing 6 to produce an injection sound to remind the user of the injection dose; the dose setting drum 11 and the bushing 12 cooperate to produce an injection sound to remind the user of the dose setting.

[0065] Example 2

[0066] Referring to FIG10 , this embodiment differs from the first embodiment in that the push rod 8 and the push plate 5 are integrally formed, and a radially extending through slot 82 is provided at the front end thereof to facilitate deformation and assembly during assembly, thereby reducing the number of components and simplifying the assembly process.

[0067] The remaining structures and functions can refer to those described in the first embodiment.

Claims

1. A drug delivery device capable of setting and resetting a dose, comprising a cartridge holder (2), a detachable cap (1) being provided at the front end of the cartridge holder (2), a cartridge bottle (3) being installed in the cartridge holder (2), and a housing (6) being connected to the rear end of the cartridge holder (2), characterized in that: The housing (6) is provided with A push rod (8), used to deliver the drug after moving according to a set dose during injection; The rotor (4) is threadedly connected to the push rod (8) and is used to rotate and drive the push rod (8) to move axially forward during injection, and can cooperate with the housing (6) to produce injection sound; A rotating shaft (9), the front end of which is connected to the rear end of the rotor (4), and is used to drive the rotor (4) to rotate during injection. The rotating shaft (9) can also move axially relative to the rotor (4), and can cooperate with the push rod (8) to control the final dose setting during the axial movement; A differential nut (10) is mounted on the outer side of the rear end of the rotating shaft (9) and is used for differential adjustment and driving the rotating shaft (9) to move axially; A differential screw (7) is fixed in the housing (6) and is disposed between the differential nut (10) and the dose setting drum (11), is threadedly connected to the differential nut (10) and the dose setting drum (10) for differential adjustment, and is rotationally connected to the rotor (4) and axially limits the rotor (4); The dose setting rotary drum (11) is used to drive the bushing (12) to move axially when setting the dose and cooperate with the bushing (12) to make a sound when setting the dose. When injecting, it can mesh with the bushing (12) and drive the bushing (12) to rotate, and is also used to drive the differential nut (10) to rotate synchronously; A bushing (12) connected to the inner side of the rear end of the rotating shaft (9) and used to drive the rotating shaft (9) to rotate during injection; An injection button (13) is installed in the rear end of the dose setting drum (11) and can apply force to drive the dose setting drum (11) to rotate counterclockwise and drive the bushing (12) to rotate synchronously after engaging with the dose setting drum (11).

2. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: The outer surface of the rotor (4) is provided with protruding one-way ratchet teeth (41), and the inner ring of the housing (6) is evenly distributed with notches (61). During the rotation process, the one-way ratchet teeth (41) cooperate with the notches (61) to produce injection sound.

3. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: The dose setting barrel (11) and the bushing (12) are evenly provided with meshing teeth (15) in the axial direction. When the dose setting barrel (11) rotates, the meshing teeth (15) on the dose setting barrel (11) and the meshing teeth (15) on the bushing (12) slide and cooperate to produce a dose setting sound.

4. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: The rotor (4) and the rotating shaft (9), the rotating shaft (9) and the bushing (12), and the differential nut (10) and the dose setting drum (11) are all connected via axial grooves.

5. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: The rotating shaft (9) and the differential nut (10), and the rotor (4) and the differential screw (7) are all connected in a circumferential ring.

6. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: The rear end of the push rod (8) is provided with a flange (81), and the front end of the rotating shaft (9) is provided with a step (91) inside, and the flange (81) and the step (91) can contact and limit to control the final dose setting.

7. The drug delivery device capable of setting and recalling dosage according to any one of claims 1 to 6, characterized in that: The push rod (8) is a screw rod.

8. The drug delivery device capable of setting and recalling dosage according to claim 7, characterized in that: A push plate (5) for cooperating with the piston of the cartridge bottle (3) is installed at the front end of the push rod (8).

9. The drug delivery device capable of setting and recalling dosage according to claim 8, characterized in that: The push rod (8) and the push plate (5) are an integral structure, and a radially penetrating through groove (82) is provided at the front end thereof.

10. The drug delivery device capable of setting and recalling dosage according to claim 1, characterized in that: A spring (14) for returning is provided between the injection button (13) and the bushing (12).

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