Guide wire

Abstract

The present invention makes it easy to reach a target site via a bent vessel.　A guide wire according to the present invention comprises: a core wire that has a first insertion region; and a coil that is joined to at least a portion of the first insertion region. The first insertion region includes: a first straight part; and a bent part that is adjacent to the first straight part and is closer to a base end side than the first straight part. The length of the first straight part is 1 / 4–2 / 3 times the length of the bent part.

Description

Guidewire

[0001] The present invention relates to a guidewire.

[0002] Conventionally, as disclosed in Patent Document 1, a guidewire has been proposed which is used in a stage prior to the introduction of a catheter.

[0003] JP 2011-167387 A

[0004] However, it has not been easy to reach the target site with a guidewire through a curved tube such as a blood vessel.

[0005] Therefore, one object of the present invention is to facilitate access to a target site through curved vessels, etc. Other objects of the present invention will become apparent from the description herein.

[0006] One aspect of the present invention is a guidewire comprising: a core wire having a first insertion region; and a coil joined to at least a portion of the first insertion region, wherein the first insertion region has a first straight portion and a bent portion adjacent to the first straight portion and located closer to the base end than the first straight portion, and the length of the first straight portion is 1 / 4 to 2 / 3 times the length of the bent portion.

[0007] According to the above aspect of the present invention, it is possible to easily reach a target site through a curved tube or the like.

[0008] FIG. 1 is a side view of a first guide wire in a first embodiment. FIG. 2 is an enlarged side view of a first insertion portion of the first guide wire. FIG. 3 is a perspective view of a first core wire before bending and before a first coil is attached. FIG. 4 is a perspective view of the first core wire before bending and after a first coil is attached. FIG. 5 is a cross-sectional configuration diagram of the first guide wire before bending. FIG. 6 is a side view of an eleventh coil. FIG. 7 is a side view of a twelfth coil. FIG. 8 is a cross-sectional configuration diagram of a second guide wire in a second embodiment. FIG. 9 is a perspective view of a second core wire before a second coil is attached. FIG. 10 is a perspective view of a second core wire after a second coil is attached.

[0009] (First embodiment) A first guide wire 10 according to a first embodiment will be described below with reference to the drawings. Note that the embodiments are not limited to the following embodiments. Furthermore, the content described in one embodiment is, in principle, also applicable to other embodiments. Furthermore, the embodiments and modifications can be combined as appropriate.

[0010] To explain the directions, the front-to-rear direction in which the first guide wire 10 extends from the first base end 12a to the first tip end 12b when the first guide wire 10 is extended straight will be referred to as the x-direction, the left-to-right direction perpendicular to the x-direction will be referred to as the y-direction, and the approximately vertical direction perpendicular to the x- and y-directions will be referred to as the z-direction. In Figures 1 to 7, the directions indicated by the arrows on the x, y, and z-axes will be defined as the front, left, and upward directions, respectively. However, the definitions of the x-direction and the like are merely examples, and the x-direction may represent the left-to-right direction and the y-direction the front-to-rear direction, for example.

[0011] However, even when the first guide wire 10 is extended straight, the 11th insertion region 11a1 and a portion of the 11th coil 15a remain bent at a predetermined angle θ with the x direction when viewed from the y direction.

[0012] To facilitate understanding of the configuration of each part, the aspect ratios of some components in Fig. 1 and other figures do not match those described in the first embodiment. In particular, the region where the first core wire 11 and the first coil 15 are joined (e.g., the eleventh joining region 16a) has an x-direction dimension of approximately 0.5 mm, which is very short compared to other parts. To illustrate the structure of the eleventh insertion region 11a1, Figs. 1 and 2 show the eleventh insertion region 11a1 longer than Figs. 3 and 4. To illustrate the structure of the first insertion portion 11a and the first coil 15, Fig. 5 shows the eleventh to thirteenth insertion regions 11a1 to 11a3 longer than Figs. 3 and 4.

[0013] (First Guide Wire 10) As shown in Figures 1 and 2, the first guide wire 10 according to the first embodiment includes a first core wire 11, a first coil 15, and a first joint 16. The first guide wire 10 is flexible and is introduced into a body cavity, such as a blood vessel, via a guide wire supplying tool and a puncturing tool (not shown). For example, the first guide wire 10 is used in a step prior to the introduction of a catheter in percutaneous transluminal angioplasty (PTA).

[0014] (First Core Wire 11) The first core wire 11 is composed of a first insertion portion (distal portion) 11a that is inserted into the body, and a first holding portion (proximal portion) 11b that is held by a surgeon or the like to insert the first insertion portion 11a. The surgeon holds the portion of the first guide wire 10 on the first base end portion 12a side and pushes, pulls, and twists it. This causes the portion of the first guide wire 10 on the first tip end portion 12b side to move inside the body.

[0015] (First Insertion Portion 11a) The first insertion portion 11a has an eleventh insertion region 11a1 to a fifteenth insertion region 11a5. The eleventh insertion region 11a1 to the fifteenth insertion region 11a5 are integrally formed. The first insertion portion 11a is made of a first material including a shape memory alloy. A hydrophilic coating is applied to the surface of the first insertion portion 11a. By applying a hydrophilic coating to the surface of the first insertion portion 11a, the first insertion portion 11a can pass through the tube more easily than in a configuration without a hydrophilic coating.

[0016] (Eleventh Insertion Region 11a1) The eleventh insertion region 11a1 includes a first distal end 12b located at the farthest end from the first base end 12a and has a generally rectangular parallelepiped shape with a rectangular y-z cross section. The generally rectangular parallelepiped shape of the eleventh insertion region 11a1 has an x-z ​​plane perpendicular to the y direction and an x-y plane perpendicular to the z direction. The generally rectangular parallelepiped shape of the eleventh insertion region 11a1 is formed by, for example, pressing a generally cylindrical material. The eleventh insertion region 11a1 constitutes a first linear portion 13a, a bent portion 13b, and a second linear portion 13c.

[0017] As shown in FIG. 3 , the z-direction dimension (111th width w111) of the approximately rectangular parallelepiped shape of the 11th insertion region 11a1 is smaller than the y-direction dimension (101st width w101) of the approximately rectangular parallelepiped shape of the 11th insertion region 11a1 (w111<w101). The 101st width w101 corresponds to the length of the long side of the rectangle in the y-z cross section of the 11th insertion region 11a1. The 111st width w111 corresponds to the length of the short side of the rectangle in the y-z cross section of the 11th insertion region 11a1. The 11th insertion region 11a1 has a wide surface (xy surface) having a y-direction dimension of the 101st width w101 and a narrow surface (xz surface) having a z-direction dimension of the 111st width w111.

[0018] (First straight portion 13a, bent portion 13b, second straight portion 13c) The eleventh insertion region 11a1 of the first insertion portion 11a of the first core wire 11 includes a first straight portion (non-bent portion) 13a, a bent portion 13b, and a second straight portion (non-bent portion) 13c (see FIG. 2). The first straight portion 13a is located at the first distal end portion 12b of the eleventh insertion region 11a1. The first straight portion 13a is not bent. The bent portion 13b is adjacent to the first straight portion 13a and is located closer to the first base end 12a than the first straight portion 13a. The bent portion 13b is bent. The second straight portion 13c is adjacent to the bent portion 13b and is located closer to the first base end 12a than the bent portion 13b. The second straight portion 13c is not bent. The bent portion 13b is located between the first linear portion 13a and the second linear portion 13c. The second linear portion 13c may be configured in the twelfth insertion region 11a2.

[0019] The bending is performed by applying a force in the z direction to the eleventh insertion region 11a1 so that, as viewed from the y direction, a line parallel to the extension direction of the first linear portion 13a and a line parallel to the extension direction of the second linear portion 13c form a predetermined angle θ. For example, the predetermined angle θ is 70 to 85 degrees, with 75 degrees being most preferable. In other words, the bending in the z direction is performed by applying force to a wide surface (xy surface) wider than the narrow surface (xz surface) of the rectangular parallelepiped shape that constitutes the outer shape of the bent portion 13b, rather than applying force to the narrow surface.

[0020] The length of the first straight portion 13a (first length L1) is shorter than the length of the bent portion 13b (second length L2) (L1<L2). The first length L1 is approximately 1 / 4 to 2 / 3 times the second length L2, and 1 / 3 is most preferable.

[0021] The bending process may be performed before the first coil 15 is attached to the first core wire 11 or after the first coil 15 is attached to the first core wire 11 .

[0022] (Twelfth Insertion Region 11a2) The twelfth insertion region 11a2 is adjacent to the eleventh insertion region 11a1 and is closer to the first base end 12a than the eleventh insertion region 11a1. The yz cross section of the twelfth insertion region 11a2 has a generally rectangular shape on the eleventh insertion region 11a1 side and a generally circular shape on the thirteenth insertion region 11a3 side. That is, the twelfth insertion region 11a2 on the eleventh insertion region 11a1 side has a truncated quadrangular pyramid shape whose yz cross section becomes smaller and sharper as it moves away from the first base end 12a. Furthermore, the thirteenth insertion region 11a3 side of the twelfth insertion region 11a2 has a generally truncated cone shape whose diameter increases as it approaches the first base end 12a.

[0023] The x-direction dimension of the twelfth insertion region 11a2 (twelfth length L12) is shorter than the x-direction dimension of the eleventh insertion region 11a1 (eleventh length L11) (L12<L11). The twelfth length L12 is approximately ⅓ of the eleventh length L11.

[0024] The diameter (101st diameter d101) of the region of the 12th insertion region 11a2 that contacts the 13th insertion region 11a3 is longer than the short side (111th width w111) of the rectangle in the yz cross section of the 11th insertion region 11a1, but shorter than the long side (101st width w101) of the rectangle in the yz cross section of the 11th insertion region 11a1 (w111 < d101 < w101).

[0025] The thirteenth insertion region 11a3 is adjacent to the twelfth insertion region 11a2 and is closer to the first base end 12a than the twelfth insertion region 11a2. The thirteenth insertion region 11a3 has a generally truncated cone shape whose diameter increases as it approaches the first base end 12a.

[0026] The x-direction dimension of the thirteenth insertion region 11a3 (thirteenth length L13) is longer than the x-direction dimension of the eleventh insertion region 11a1 (eleventh length L11) (L13>L11). The thirteenth length L13 is approximately five times the eleventh length L11.

[0027] The diameter (102nd diameter d102) of the region of the 13th insertion region 11a3 that contacts the 14th insertion region 11a4 is longer than the long side (101st width w101) of the rectangle in the yz cross section of the 11th insertion region 11a1 (d102>w101). The 102nd diameter d102 is approximately twice the 101st width w101.

[0028] The fourteenth insertion region 11a4 is adjacent to the thirteenth insertion region 11a3 and is closer to the first base end 12a than the thirteenth insertion region 11a3. The fourteenth insertion region 11a4 has a generally truncated cone shape whose diameter increases as it approaches the first base end 12a.

[0029] The taper angle of the generally truncated cone shape of the fourteenth insertion region 11a4 is smaller than the taper angle of the generally truncated cone shape of the thirteenth insertion region 11a3.

[0030] The x-direction dimension of the fourteenth insertion region 11a4 (fourteenth length L14) is longer than the x-direction dimension of the thirteenth insertion region 11a3 (thirteenth length L13) (L14>L13). The fourteenth length L14 is approximately three to four times the thirteenth length L13.

[0031] The diameter of the region of the 14th insertion region 11a4 where it contacts the 15th insertion region 11a5 (the 103rd diameter d103) is larger than the diameter of the region of the 14th insertion region 11a4 where it contacts the 13th insertion region 11a3 (the 102nd diameter d102) (d103>d102). The 103rd diameter d103 is approximately 1.8 times the 102nd diameter d102.

[0032] The fifteenth insertion region 11a5 is adjacent to the fourteenth insertion region 11a4 and is closer to the first base end 12a than the fourteenth insertion region 11a4. The fifteenth insertion region 11a5 has a substantially cylindrical shape with a uniform diameter (diameter d103).

[0033] The x-direction dimension of the fifteenth insertion region 11a5 (fifteenth length L15) is shorter than the x-direction dimension of the fourteenth insertion region 11a4 (fourteenth length L14) (L15<L14). The fifteenth length L15 is approximately 0.4 to 0.5 times the fourteenth length L14.

[0034] (First holding portion 11b) The first holding portion 11b is made of a second material different from the first material. The first holding portion 11b has an eleventh holding area 11b1 and a twelfth holding area 11b2. The eleventh holding area 11b1 and the twelfth holding area 11b2 are integrally formed.

[0035] The eleventh holding region 11b1 is adjacent to the fifteenth insertion region 11a5 and is closer to the first base end 12a than the fifteenth insertion region 11a5. The eleventh holding region 11b1 has a substantially cylindrical shape with a uniform diameter (a 103rd diameter d103).

[0036] The fifteenth insertion region 11a5 of the first insertion portion 11a and the eleventh holding region 11b1 of the first holding portion 11b are integrally formed by thermal bonding.

[0037] The x-direction dimension of the eleventh holding region 11b1 (sixteenth length L16) is shorter than the x-direction dimension of the fifteenth insertion region 11a5 (fifteenth length L15) (L16<L15). The sixteenth length L16 is approximately 0.2 times the fifteenth length L15.

[0038] (Twelfth holding region 11b2) The twelfth holding region 11b2 is adjacent to the eleventh holding region 11b1 and is closer to the first base end 12a than the eleventh holding region 11b1. The twelfth holding region 11b2 has a substantially cylindrical shape with a uniform diameter (a 104th diameter d104).

[0039] The x-direction dimension of the twelfth hold region 11b2 (seventeenth length L17) is longer than the x-direction dimension of the eleventh hold region 11b1 (sixteenth length L16) (L17>L16). The seventeenth length L17 is approximately 70 times the sixteenth length L16.

[0040] The surface of the twelfth holding region 11b2 of the first holding portion 11b is coated with PTFE (polytetrafluoroethylene). Due to the PTFE coating, the diameter of the twelfth holding region 11b2 (the 104th diameter d104) is larger than the diameter of the eleventh holding region 11b1 (the 103rd diameter d103) (d104 > d103). In other words, the 111th width w111 is approximately 1 / 10 to 1 / 5 of the 104th diameter d104.

[0041] (First Coil 15) As shown in Figures 4 and 5, the first coil 15 has an eleventh coil 15a and a twelfth coil 15b. The first coil 15 is attached to the eleventh to thirteenth insertion regions 11a1 to 11a3 of the first insertion portion 11a of the first core wire 11. The eleventh coil 15a and the twelfth coil 15b have the same winding direction. The outer diameters (the 105 diameter d105) of the eleventh coil 15a and the twelfth coil 15b are larger than the 102 diameter d102 (d105>d102). A hydrophilic coating is applied to the surface of the first coil 15.

[0042] (Eleventh coil 15a) The eleventh coil 15a includes an eleventh front coil region 15a1, an eleventh main coil region 15a2, and an eleventh rear coil region 15a3. The eleventh coil 15a is made of a third material that has a higher density than the first material of the first insertion portion 11a. The eleventh front coil region 15a1, the eleventh main coil region 15a2, and the eleventh rear coil region 15a3 are integrally formed.

[0043] 6, the eleventh distal end coil region 15a1 is located on the first distal end portion 12b side. The coil pitch of the eleventh distal end coil region 15a1 is wider than the coil pitch of the eleventh main coil region 15a2.

[0044] The eleventh distal coil region 15a1 is soldered to the first distal end portion 12b of the eleventh insertion region 11a1 of the first insertion portion 11a of the first core wire 11. This joining forms an eleventh joint region 16a. The distal end of the eleventh joint region 16a (the region furthest from the first base end portion 12a) is formed in a hemispherical shape (see FIGS. 4 and 5).

[0045] (Eleventh main coil region 15a2) The eleventh main coil region 15a2 is a main portion of the eleventh coil 15a. The eleventh main coil region 15a2 is adjacent to the eleventh front end coil region 15a1 on the front side in the x direction and adjacent to the eleventh rear end coil region 15a3 on the rear side in the x direction.

[0046] (Eleventh Rear-End Coil Region 15a3) The eleventh rear-end coil region 15a3 is located on the first base end portion 12a side. The coil pitch of the eleventh rear-end coil region 15a3 is wider than the coil pitch of the eleventh main coil region 15a2.

[0047] 7, the 12th coil 15b includes a 12th front coil region 15b1, a 12th main coil region 15b2, and a 12th rear coil region 15b3. The 12th coil 15b is made of the second material. The 12th front coil region 15b1, the 12th main coil region 15b2, and the 12th rear coil region 15b3 are integrally formed.

[0048] (Twelfth front end coil region 15b1) The twelfth front end coil region 15b1 is located on the first front end portion 12b side. The coil pitch of the twelfth front end coil region 15b1 is wider than the coil pitch of the twelfth main coil region 15b2. The eleventh rear end coil region 15a3 and the twelfth front end coil region 15b1 are configured with a bifilar winding in which the windings of the eleventh rear end coil region 15a3 and the windings of the twelfth front end coil region 15b1 are arranged alternately.

[0049] The twelfth front end coil region 15b1 is joined to the eleventh rear end coil region 15a3 by soldering, thereby forming a twelfth joining region 16b (see FIGS. 4 and 5).

[0050] (Twelfth main coil region 15b2) The twelfth main coil region 15b2 is a main part of the twelfth coil 15b. The twelfth main coil region 15b2 is adjacent to the twelfth front coil region 15b1 on the front side in the x direction and adjacent to the twelfth rear coil region 15b3 on the rear side in the x direction.

[0051] (Twelfth Rear-End Coil Region 15b3) The twelfth rear-end coil region 15b3 is located on the first base end portion 12a side. The coil pitch of the twelfth rear-end coil region 15b3 is wider than the coil pitch of the twelfth main coil region 15b2.

[0052] The twelfth rear end coil region 15b3 is joined by soldering to a region of the thirteenth insertion region 11a3 on the fourteenth insertion region 11a4 side, forming a thirteenth joining region 16c.

[0053] The x-direction dimension of the eleventh coil 15a (eleventh coil length LC11) is longer than the x-direction dimension of the eleventh insertion region 11a1 (eleventh length L11) (LC11>L11). The x-direction dimension of the eleventh coil 15a (eleventh coil length LC11) is shorter than the x-direction dimension of the twelfth coil 15b (twelfth coil length LC12) (LC11<LC12). The eleventh coil length LC11 is approximately 0.6 times the twelfth coil length LC12 and approximately 2.3 times the eleventh length L11.

[0054] (First Joint 16) The first joint 16 includes an eleventh joint region 16a, a twelfth joint region 16b, and a thirteenth joint region 16c. In the eleventh joint region 16a, the eleventh insertion region 11a1 of the first insertion portion 11a of the first core wire 11 is joined to the eleventh front coil region 15a1 of the eleventh coil 15a of the first coil 15. In the twelfth joint region 16b, the eleventh rear end coil region 15a3 of the eleventh coil 15a of the first coil 15, the twelfth front coil region 15b1 of the twelfth coil 15b, and the thirteenth insertion region 11a3 of the first insertion portion 11a of the first core wire 11 are joined. In the thirteenth joining region 16c, the thirteenth insertion region 11a3 of the first insertion portion 11a of the first core wire 11 and the twelfth rear end coil region 15b3 of the twelfth coil 15b of the first coil 15 are joined.

[0055] (Tapered Shape of the Thirteenth Bonding Region 16c) In order to reduce the possibility of the first guide wire 10 getting caught on a catheter or the like that is combined with the first guide wire 10, it is desirable that the thirteenth bonding region 16c on the first base end 12a side have a tapered shape in which the diameter decreases as it approaches the first base end 12a.

[0056] (Effect of Length Ratio of Bending) By providing the first straight portion 13a, which is not bent and has a length that is one-third of the length of the bent portion 13b, on the first tip portion 12b side of the bent portion 13b, the first straight portion 13a acts as a trigger for displacement in a desired direction. As a result, compared to a configuration in which the first straight portion 13a is not provided and has a length that is one-third the length of the bent portion 13b, the first guide wire 10 can be twisted, pushed, or pulled to move the first tip portion 12b in a desired direction, making it easier to reach the target site through a curved or narrowed tube.

[0057] (Effect of Bending Angle) By bending at a predetermined angle θ (70 degrees to 85 degrees), the convex portion of the bent portion 13b triggers displacement in the desired direction, and by twisting, pushing, or pulling the first guide wire 10, the first tip portion 12b can be moved in the desired direction, making it easier to reach the target site through the curved tube, compared to a configuration in which the first guide wire 10 is not bent at the predetermined angle θ.

[0058] (Effect of bending area) Compared to a form formed by applying force to the narrow surface (xz surface) of the rectangular parallelepiped shape of the bending portion 13b, the wide surface (xy surface) is easier to bend and it is easier to form a bend at the desired angle.

[0059] (Effect of forming the rectangular parallelepiped shape of the eleventh insertion region 11a1 including the bending portion 13b by press working) By applying press working to a member of another shape, such as a cylinder, the eleventh insertion region 11a1 can be formed integrally with other regions, such as the twelfth insertion region 11a2. Furthermore, because the rectangular parallelepiped shape of the eleventh insertion region 11a1 is formed by press working, directionality can be imparted when bending, making the bending portion 13b easier to bend.

[0060] (Effect of the eleventh insertion region 11a1 including the bent portion 13b being made of a shape memory alloy) The desired shape obtained by bending can be easily maintained.

[0061] (Effect of making the short side of the rectangle in the yz cross section of the eleventh insertion region 11a1 1 / 10 to 1 / 5 of the diameter of the first base end 12a) The second moment of area of ​​the region including the first tip end 12b (eleventh insertion region 11a1) can be made 1% or less of the second moment of area of ​​the region including the first base end 12a (twelfth holding region 11b2), which increases the rigidity on the first base end 12a side and makes it easier to design a configuration in which the first tip end 12b side is more easily bent.

[0062] (Effect of widening the coil pitch of the eleventh distal end coil region 15a1) The joining material can easily enter the eleventh joining region 16a, facilitating joining to the eleventh insertion region 11a1.

[0063] (Effect of making the winding direction of the 11th coil 15a and the 12th coil 15b the same and widening the coil pitch of the 11th rear end coil region 15a3 and the 12th front end coil region 15b1) The coils in the 11th rear end coil region 15a3 and the coils in the 12th front end coil region 15b1 are easily entangled, and the joining material can easily enter the 12th joining region 16b, making it easier to join the 11th coil 15a and the 12th coil 15b.

[0064] (Effect of constructing the 11th coil 15a from a high-density material) By using the 11th coil 15a, it is possible to form an area on the first tip portion 12b side that is easily projected on an X-ray image without adding other components such as an X-ray marker.

[0065] Second Embodiment Next, a second embodiment will be described.

[0066] To explain the directions, the front-to-rear direction in which the second guide wire 20 extends from the second base end 22a to the second tip end 22b when the second guide wire 20 is extended straight will be referred to as the x-direction, the left-to-right direction perpendicular to the x-direction will be referred to as the y-direction, and the approximately vertical direction perpendicular to the x- and y-directions will be referred to as the z-direction. In Figures 8 to 10, the directions indicated by the arrows on the x, y, and z-axes will be defined as the front, left, and upward directions, respectively. However, the definitions of the x-direction and the like are merely examples, and the x-direction may represent the left-to-right direction and the y-direction the front-to-rear direction, for example.

[0067] To facilitate understanding of the configuration of each part, the aspect ratios of some components in Fig. 8 and other figures do not match those described in the second embodiment. In particular, the region where the second core wire 21 and the second coil 25 are joined (e.g., the 21st joining region 26a) has a dimension in the x direction of approximately 0.5 mm, which is very short compared to other parts. Furthermore, to illustrate the structure of the second insertion portion 21a and the second coil 25, the 21st insertion region 21a1 to the 27th insertion region 21a7 are shown longer in Fig. 8 than in Figs. 9 and 10.

[0068] (Second Guide Wire 20) As shown in Fig. 8, the second guide wire 20 according to the second embodiment includes a second core wire 21, a second coil 25, and a second joint 26. The second guide wire 20 is flexible and is introduced into a body cavity, such as a blood vessel, via a guide wire supplying tool and a puncturing tool (not shown). For example, the second guide wire 20 is used in a preliminary step of introducing a catheter in interventional radiology (IVR).

[0069] (Second Core Wire 21) The second core wire 21 is composed of a second insertion portion (distal portion) 21a that is inserted into the body, and a second holding portion (proximal portion) 21b that is held by a surgeon or the like to insert the second insertion portion 21a. The surgeon holds the portion of the second guide wire 20 on the second base end portion 22a side and pushes, pulls, and twists it. This causes the portion of the second guide wire 20 on the second tip end portion 22b side to move inside the body.

[0070] (Second Insertion Portion 21a) The second insertion portion 21a has a 21st insertion region 21a1 to a 29th insertion region 21a9. The 21st insertion region 21a1 to the 29th insertion region 21a9 are integrally formed. The second insertion portion 21a is made of a first material including a shape memory alloy. A hydrophilic coating is applied to the surface of the second insertion portion 21a.

[0071] (21st insertion region 21a1) The 21st insertion region 21a1 includes the second tip end 22b located at the farthest end from the second base end 22a and has a substantially rectangular parallelepiped shape with a rectangular y-z cross section. As shown in Figure 9, the substantially rectangular parallelepiped shape of the 21st insertion region 21a1 has an x-z ​​plane perpendicular to the y direction and an x-y plane perpendicular to the z direction. The substantially rectangular parallelepiped shape of the 21st insertion region 21a1 is formed by pressing a substantially cylindrical material, for example.

[0072] The dimension in the z direction of the approximately rectangular parallelepiped shape of the second insertion region 21a1 (width w211) is smaller than the dimension in the y direction of the approximately rectangular parallelepiped shape of the second insertion region 21a1 (width w201) (w211<w201). The second insertion region 21a1 has a wide surface (xy surface) having a y direction dimension of width w201 and a narrow surface (xz surface) having a z direction dimension of width w211.

[0073] (22nd Insertion Region 21a2) The 22nd insertion region 21a2 is adjacent to the 21st insertion region 21a1 and is closer to the second base end 22a than the 21st insertion region 21a1. The yz cross section of the 22nd insertion region 21a2 has a substantially rectangular shape. The 22nd insertion region 21a2 has a truncated quadrangular pyramid shape whose yz cross section increases with increasing distance from the second base end 22a.

[0074] The x-direction dimension of the 22nd insertion region 21a2 (22nd length L22) is longer than the x-direction dimension of the 21st insertion region 21a1 (21st length L21) (L22>L21). The 22nd length L22 is approximately seven times the 21st length L21.

[0075] The y-direction dimension (202nd width w202) of the region of the 22nd insertion region 21a2 that contacts the 23rd insertion region 21a3 is longer than the short side (211th width w211) of the rectangle in the y-z cross section of the 21st insertion region 21a1, but shorter than the long side (201st width w201) of the rectangle in the y-z cross section of the 21st insertion region 21a1 (w211 < w202 < w201).

[0076] The z-direction dimension (212th width w212) of the region of the 22nd insertion region 21a2 that contacts the 23rd insertion region 21a3 is longer than the short side (211th width w211) of the rectangle in the yz cross section of the 21st insertion region 21a1, but shorter than the long side (201st width w201) of the rectangle in the yz cross section of the 21st insertion region 21a1 (w211 < w212 < w201).

[0077] (23rd Insertion Region 21a3) The 23rd insertion region 21a3 is adjacent to the 22nd insertion region 21a2 and is closer to the second base end 22a than the 22nd insertion region 21a2. The yz cross section of the 23rd insertion region 21a3 has a substantially rectangular shape. The 23rd insertion region 21a3 has a truncated quadrangular pyramid shape whose yz cross section becomes smaller with increasing distance from the second base end 22a.

[0078] The x-direction dimension of the 23rd insertion region 21a3 (23rd length L23) is longer than the x-direction dimension of the 21st insertion region 21a1 (21st length L21) and shorter than the x-direction dimension of the 22nd insertion region 21a2 (22nd length L22) (L22 > L23 > L21). The 23rd length L23 is approximately 4.5 times the 21st length L21.

[0079] The y-direction dimension (203rd width w203) of the region of the 23rd insertion region 21a3 that contacts the 24th insertion region 21a4 is longer than the y-direction dimension (202nd width w202) of the region of the 22nd insertion region 21a2 that contacts the 23rd insertion region 21a3 (w203 > w202).

[0080] The z-direction dimension (213th width w213) of the region of the 23rd insertion region 21a3 that contacts the 23rd insertion region 21a3 is longer than the z-direction dimension (212th width w212) of the region of the 22nd insertion region 21a2 that contacts the 23rd insertion region 21a3 (w213 > w212).

[0081] (24th Insertion Region 21a4) The 24th insertion region 21a4 is adjacent to the 23rd insertion region 21a3 and is closer to the second base end 22a than the 23rd insertion region 21a3. The yz cross section of the 24th insertion region 21a4 has a generally rectangular shape on the 23rd insertion region 21a3 side and a generally circular shape on the 25th insertion region 21a5 side. That is, the yz cross section of the 24th insertion region 21a4 on the 23rd insertion region 21a3 side has a truncated quadrangular pyramid shape whose yz cross section becomes smaller and whose corners become sharper as it moves away from the second base end 22a. Furthermore, the 24th insertion region 21a4 on the 25th insertion region 21a5 side has a generally truncated cone shape whose diameter increases as it approaches the second base end 22a.

[0082] The x-direction dimension of the 24th insertion region 21a4 (24th length L24) is longer than the x-direction dimension of the 23rd insertion region 21a3 (23rd length L23) (L24>L23). The 24th length L24 is approximately three times the 23rd length L23.

[0083] The diameter (201st diameter d201) of the region of the 24th insertion region 21a4 that contacts the 25th insertion region 21a5 is longer than the y-direction dimension (203rd width w203) of the region of the 23rd insertion region 21a3 that contacts the 24th insertion region 21a4 and the z-direction dimension (213th width w213) of the region of the 23rd insertion region 21a3 that contacts the 23rd insertion region 21a3 (d201>w203, d201>w213).

[0084] The 25th insertion region 21a5 is adjacent to the 24th insertion region 21a4 and is closer to the second base end 22a than the 24th insertion region 21a4. The 25th insertion region 21a5 has a generally truncated cone shape whose diameter increases as it approaches the second base end 22a.

[0085] The taper angle of the generally truncated cone shape of the 25th insertion region 21a5 is smaller than the taper angle of the generally truncated cone shape of the 24th insertion region 21a4.

[0086] The x-direction dimension of the 25th insertion region 21a5 (25th length L25) is longer than the x-direction dimension of the 24th insertion region 21a4 (24th length L24) (L25>L24). For example, the 25th length L25 is approximately 1.6 times the 24th length L24.

[0087] The diameter of the region of the 25th insertion region 21a5 that contacts the 26th insertion region 21a6 (the 202nd diameter d202) is larger than the diameter of the region of the 24th insertion region 21a4 that contacts the 25th insertion region 21a5 (the 201st diameter d201) (d202>d201). The 202nd diameter d202 is approximately 1.25 times the 201st diameter d201.

[0088] (26th Insertion Region 21a6) The 26th insertion region 21a6 is adjacent to the 25th insertion region 21a5 and is closer to the second base end 22a than the 25th insertion region 21a5. The 26th insertion region 21a6 has a generally truncated cone shape whose diameter increases as it approaches the second base end 22a.

[0089] The taper angle of the generally truncated cone shape of the 26th insertion region 21a6 is smaller than the taper angle of the generally truncated cone shape of the 25th insertion region 21a5.

[0090] The x-direction dimension of the 26th insertion region 21a6 (26th length L26) is longer than the x-direction dimension of the 25th insertion region 21a5 (25th length L25) (L26>L25). The 26th length L26 is approximately three times the 25th length L25.

[0091] The diameter of the region of the 26th insertion region 21a6 where it contacts the 27th insertion region 21a7 (the 203rd diameter d203) is larger than the diameter of the region of the 26th insertion region 21a6 where it contacts the 25th insertion region 21a5 (the 202nd diameter d202) (d203>d202). The 203rd diameter d203 is approximately 1.15 times the 202nd diameter d202.

[0092] The 27th insertion region 21a7 is adjacent to the 26th insertion region 21a6 and is closer to the second base end 22a than the 26th insertion region 21a6. The 27th insertion region 21a7 has a substantially cylindrical shape with a uniform diameter (diameter d203).

[0093] The x-direction dimension of the 27th insertion region 21a7 (27th length L27) is shorter than the x-direction dimension of the 26th insertion region 21a6 (26th length L26) (L27<L26). The 27th length L27 is approximately 0.4 times the 26th length L26.

[0094] (28th Insertion Region 21a8) The 28th insertion region 21a8 is adjacent to the 27th insertion region 21a7 and is closer to the second base end 22a than the 27th insertion region 21a7. The 28th insertion region 21a8 has a generally truncated cone shape whose diameter increases as it approaches the second base end 22a.

[0095] The taper angle of the generally truncated cone shape of the 28th insertion region 21a8 is larger than the taper angle of the generally truncated cone shape of the 26th insertion region 21a6.

[0096] The x-direction dimension of the 28th insertion region 21a8 (28th length L28) is longer than the x-direction dimension of the 27th insertion region 21a7 (27th length L27) (L28>L27). The 28th length L28 is approximately 2.3 times the 27th length L27.

[0097] The diameter of the region of the 28th insertion region 21a8 that contacts the 29th insertion region 21a9 (the 204th diameter d204) is larger than the diameter of the region of the 28th insertion region 21a8 that contacts the 27th insertion region 21a7 (the 203rd diameter d203) (d204>d203). The 204th diameter d204 is approximately 1.5 times the 203rd diameter d203.

[0098] The 29th insertion region 21a9 is adjacent to the 28th insertion region 21a8 and is closer to the second base end 22a than the 28th insertion region 21a8. The 29th insertion region 21a9 has a substantially cylindrical shape with a uniform diameter (204th diameter d204).

[0099] The x-direction dimension of the 29th insertion region 21a9 (29th length L29) is shorter than the x-direction dimension of the 28th insertion region 21a8 (28th length L28) (L29<L28). The 29th length L29 is approximately 0.35 times the 28th length L28.

[0100] (Taper Angle) The second insertion section 21a of the second core wire 21 has at least four insertion regions (five in the second embodiment, the 23rd insertion region 21a3, the 24th insertion region 21a4, the 25th insertion region 21a5, the 26th insertion region 21a6, and the 28th insertion region 21a8) each having a truncated pyramid shape whose cross section increases toward the second base end 22a or a truncated cone shape whose diameter increases toward the second base end 22a. However, four or more such tapered insertion regions may be provided. The taper angle of the 23rd insertion region 21a3 (first tapered portion) is larger than the 24th insertion region 21a4 (second tapered portion). The taper angle of the 24th insertion region 21a4 (second tapered portion) is larger than the taper angle of the 25th insertion region 21a5 (third tapered portion). The taper angle of the 25th insertion region 21a5 (third tapered portion) is larger than the taper angle of the 26th insertion region 21a6 (fourth tapered portion), and the taper angle of the 26th insertion region 21a6 (fourth tapered portion) is smaller than the taper angle of the 28th insertion region 21a8 (fifth tapered portion).

[0101] (Second holding portion 21b) The second holding portion 21b is made of a second material different from the first material. The second holding portion 21b has a first holding area 21b1 and a second holding area 21b2. The first holding area 21b1 and the second holding area 21b2 are integrally formed.

[0102] (21st holding region 21b1) The 21st holding region 21b1 is adjacent to the 29th insertion region 21a9 and is closer to the second base end 22a than the 29th insertion region 21a9. The 21st holding region 21b1 has a substantially cylindrical shape with a uniform diameter (204th diameter d204).

[0103] The 29th insertion region 21a9 of the second insertion portion 21a and the 21st holding region 21b1 of the second holding portion 21b are integrally formed by thermal bonding.

[0104] The x-direction dimension of the 21st holding region 21b1 (a thirtieth length L30) is shorter than the x-direction dimension of the 29th insertion region 21a9 (a thirtieth length L29) (L30<L29). The thirtieth length L30 is approximately 0.4 times the 29th length L29.

[0105] (22nd holding region 21b2) The 22nd holding region 21b2 is adjacent to the 21st holding region 21b1 and is closer to the second base end 22a than the 21st holding region 21b1. The 22nd holding region 21b2 has a substantially cylindrical shape with a uniform diameter (205th diameter d205).

[0106] The x-direction dimension of the 22nd hold region 21b2 (a 31st length L31) is longer than the x-direction dimension of the 21st hold region 21b1 (a 30th length L30) (L31>L30). The 31st length L31 is approximately 80 times the 30th length L30.

[0107] The surface of the second holding portion 21b's second holding region 21b2 is coated with PTFE (polytetrafluoroethylene). Due to the PTFE coating, the diameter of the second holding region 21b2 (the second diameter d205) is larger than the diameter of the first holding region 21b1 (the second diameter d204) (d205>d204).

[0108] (Second Coil 25) As shown in Figure 10, the second coil 25 has a 21st coil 25a and a 22nd coil 25b. The second coil 25 is attached to the 21st insertion region 21a1 to the 27th insertion region 21a7 of the second insertion portion 21a of the second core wire 21. The 21st coil 25a and the 22nd coil 25b have the same winding direction. The outer diameters (206 diameter d206) of the 21st coil 25a and the 22nd coil 25b are larger than the 203 diameter d203 (d206 > d203). A hydrophilic coating is applied to the surface of the second coil 25.

[0109] (21st coil 25a) The 21st coil 25a includes a 21st front coil region 25a1, a 21st main coil region 25a2, and a 21st rear coil region 25a3 (see FIG. 8). The 21st coil 25a is made of a third material that has a higher density than the first material of the second insertion portion 21a. The 21st front coil region 25a1, the 21st main coil region 25a2, and the 21st rear coil region 25a3 are integrally formed.

[0110] (21st Distal End Coil Region 25a1) The 21st distal end coil region 25a1 is located on the second distal end portion 22b side. The coil pitch of the 21st distal end coil region 25a1 is wider than the coil pitch of the 21st main coil region 25a2.

[0111] The 21st distal coil region 25a1 is joined by soldering to the second distal end portion 22b of the 21st insertion region 21a1 of the second insertion portion 21a of the second core wire 21. This joining forms the 21st joining region 26a. The distal end of the 21st joining region 26a (the region furthest from the second base end 22a) is formed in a hemispherical shape.

[0112] (21st main coil region 25a2) The 21st main coil region 25a2 is a main portion of the 21st coil 25a. The 21st main coil region 25a2 is adjacent to the 21st front end coil region 25a1 on the front side in the x direction and adjacent to the 21st rear end coil region 25a3 on the rear side in the x direction.

[0113] (21st Rear-End Coil Region 25a3) The 21st rear-end coil region 25a3 is located on the second base end portion 22a side. The coil pitch of the 21st rear-end coil region 25a3 is wider than the coil pitch of the 21st main coil region 25a2.

[0114] (22nd coil 25b) The 22nd coil 25b includes a 22nd front coil region 25b1, a 22nd main coil region 25b2, and a 22nd rear coil region 25b3. The 22nd coil 25b is made of the second material. The 22nd front coil region 25b1, the 22nd main coil region 25b2, and the 22nd rear coil region 25b3 are integrally formed.

[0115] (22nd front end coil region 25b1) The 22nd front end coil region 25b1 is located on the second front end portion 22b side. The coil pitch of the 22nd front end coil region 25b1 is wider than the coil pitch of the 22nd main coil region 25b2. The 21st rear end coil region 25a3 and the 22nd front end coil region 25b1 are configured with a bifilar winding in which the windings of the 21st rear end coil region 25a3 and the 22nd front end coil region 25b1 are arranged alternately.

[0116] The 22nd front end coil region 25b1 is joined to the 21st rear end coil region 25a3 by soldering, thereby forming a 22nd joining region 26b.

[0117] (22nd main coil region 25b2) The 22nd main coil region 25b2 is a main part of the 22nd coil 25b. The 22nd main coil region 25b2 is adjacent to the 22nd front end coil region 25b1 on the front side in the x direction and adjacent to the 22nd rear end coil region 25b3 on the rear side in the x direction.

[0118] (22nd Rear-End Coil Region 25b3) The 22nd rear-end coil region 25b3 is located on the second base end portion 22a side. The coil pitch of the 22nd rear-end coil region 25b3 is wider than the coil pitch of the 22nd main coil region 25b2.

[0119] The 22nd rear end coil region 25b3 is joined to the 27th insertion region 21a7 by soldering, thereby forming a 23rd joining region 26c.

[0120] The x-direction dimension of the 21st coil 25a (21st coil length LC21) is longer than the x-direction dimension of the 21st insertion region 21a1 (21st length L21) (LC21>L21). The x-direction dimension of the 21st coil 25a (21st coil length LC21) is shorter than the x-direction dimension of the 22nd coil 25b (22nd coil length LC22) (LC21<LC22). The 21st coil length LC21 is approximately 0.2 times the 22nd coil length LC22 and approximately 25 times the 21st length L21.

[0121] (Second Joint 26) The second joint 26 includes a 21st joint region 26a, a 22nd joint region 26b, and a 23rd joint region 26c. In the 21st joint region 26a, the 21st insertion region 21a1 of the second insertion portion 21a of the second core wire 21 is joined to the 21st distal coil region 25a1 of the 21st coil 25a of the second coil 25. In the 22nd joint region 26b, the 21st proximal coil region 25a3 of the 21st coil 25a of the second coil 25, the 22nd distal coil region 25b1 of the 22nd coil 25b, and the 24th insertion region 21a4 of the second insertion portion 21a of the second core wire 21 are joined. In the 23rd joining region 26c, the 27th insertion region 21a7 of the second insertion portion 21a of the second core wire 21 and the 22nd rear end coil region 25b3 of the 22nd coil 25b of the second coil 25 are joined.

[0122] (Tapered shape of the 23rd bonding region 26c) In order to reduce the possibility of snagging on a catheter or the like combined with the second guide wire 20, it is desirable that the 23rd bonding region 26c on the second base end 22a side have a tapered shape in which the diameter decreases as it approaches the second base end 22a.

[0123] (Bending) In the second embodiment, bending is not performed as in the first embodiment, but the 21st insertion region 21a1 and the like may be bent by an operator or the like.

[0124] (Effect of widening the coil pitch of the 21st distal end coil region 25a1) The joining material can easily enter the 21st joining region 26a, facilitating joining to the 21st insertion region 21a1.

[0125] (Effect of making the winding direction of the 21st coil 25a and the 22nd coil 25b the same and widening the coil pitch of the 21st rear end coil region 25a3 and the 22nd front end coil region 25b1) The coils in the 21st rear end coil region 25a3 and the coils in the 22nd front end coil region 25b1 are easily entangled, and the joining material can easily enter the 22nd joining region 26b, making it easier to join the 21st coil 25a and the 22nd coil 25b.

[0126] (Effect of constructing the 21st coil 25a from a high-density material) By using the 21st coil 25a, it is possible to form an area on the second tip portion 22b side that is easily projected on an X-ray image without adding other components such as an X-ray marker.

[0127] (Effect of Providing Four or More Insertion Regions Having a Frustrum Shape) By providing multiple steps, it is easier to smoothly transmit torsion on the second base end portion 22a side to the second tip portion 22b side, compared to a configuration configured with a stepless taper. In particular, because four tapered portions (the 23rd insertion region 21a3, the 24th insertion region 21a4, the 25th insertion region 21a5, and the 26th insertion region 21a6) are continuously configured in the region close to the second tip portion 22b, it is easier to smoothly transmit torsion on the second base end portion 22a side to the second tip portion 22b side.

[0128] (Effect of providing the 28th insertion region 21a8 (fifth tapered portion) with a larger taper angle on the second base end 22a side) By making the taper angle of the region closer to the second tip end 22b than the fifth tapered portion smaller, it becomes easier to control subtle displacements on the second tip end 22b side when performing operations such as twisting that region.

[0129] (Correspondence of Terms) The first guide wire 10 and the second guide wire 20 correspond to the guide wires in the claims. The first core wire 11 and the second core wire 21 correspond to the core wires in the claims. The eleventh insertion region 11a1 and the twenty-first insertion region 21a1 correspond to the first insertion region in the claims. The first coil 15 and the second coil 25 correspond to the coils in the claims. The eleventh coil 15a and the twenty-first coil 25a correspond to the first coil in the claims. The eleventh distal end coil region 15a1 and the twenty-first distal end coil region 25a1 correspond to the first distal end coil region in the claims. The eleventh main coil region 15a2 and the twenty-first main coil region 25a2 correspond to the first main coil region in the claims. The eleventh proximal end coil region 15a3 and the twenty-first proximal end coil region 25a3 correspond to the first proximal end coil region in the claims. The twelfth coil 15b and the 22nd coil 25b correspond to the second coil in the claims. The twelfth distal end coil region 15b1 and the 22nd distal end coil region 25b1 correspond to the second distal end coil region in the claims. The twelfth main coil region 15b2 and the 22nd main coil region 25b2 correspond to the second main coil region in the claims.

[0130] Although several embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, substitutions, and modifications can be made without departing from the spirit of the invention. These embodiments and their modifications are intended to be included within the scope and spirit of the invention, as well as within the scope of the invention described in the claims and their equivalents.

[0131] According to the present specification, the following guidewire aspects are provided: (Aspect 1) Aspect 1 comprises a core wire having a first insertion region and a coil joined to at least a portion of the first insertion region, the first insertion region having a first straight portion and a bent portion adjacent to the first straight portion and located closer to the proximal end than the first straight portion, and the length of the first straight portion is 1 / 4 to 2 / 3 times the length of the bent portion.

[0132] According to the above-described aspect, the first straight section triggers displacement in a desired direction, which allows the distal end of the guidewire to be moved in a desired direction by twisting, pushing, or pulling the guidewire, thereby facilitating the guidewire reaching a target site through a curved vessel.

[0133] (Aspect 2) In aspect 2, the first insertion region has a second straight portion adjacent to the bent portion and located closer to the base end than the bent portion, and an angle between a line parallel to the extension direction of the first straight portion and a line parallel to the extension direction of the second straight portion is 70 degrees to 85 degrees.

[0134] According to the above-described embodiment, the convex portion of the bending section triggers displacement in a desired direction, which allows the distal end of the guidewire to be moved in a desired direction by twisting, pushing, or pulling the guidewire, facilitating its reaching of the target site through a curved tube.

[0135] (Aspect 3) In aspect 3, the bent portion includes a rectangular parallelepiped shape formed by applying force to a wide surface.

[0136] According to the above-described aspect, compared to a configuration in which force is applied to the narrow surface of the rectangular parallelepiped shape of the bending portion, the wide surface (xy surface) is easier to bend and it is easier to form a bend at a desired angle.

[0137] (Aspect 4) In aspect 4, the rectangular parallelepiped shape is formed by press working, and the bent portion is made of a shape memory alloy.

[0138] According to the above-described embodiment, the first insertion region can be formed integrally with other regions by pressing a member of another shape, such as a cylinder. In addition, the desired shape after bending can be easily maintained, and even if the bent portion is deformed into an unintended shape, it can be restored to the desired shape by annealing or the like.

[0139] (Aspect 5) In aspect 5, the cross section of the rectangular parallelepiped shape is rectangular, and the length of the short side of the rectangle is 1 / 10 to 1 / 5 times the diameter of the base end side.

[0140] According to the above-described aspect, the second moment of area of ​​the region including the tip (first insertion region) can be made 1% or less of the second moment of area of ​​the region including the base end, which increases the rigidity on the base end side and makes it easier to design a configuration that makes the tip side easier to bend.

[0141] (Aspect 6) In aspect 6, the coil includes a first distal end coil region that is joined to at least a portion of the first insertion region, and a first main coil region that is adjacent to the first distal end coil region and located closer to the base end than the first distal end coil region, and the coil pitch of the first distal end coil region is wider than the coil pitch of the first main coil region.

[0142] According to the above-described aspect, the joining member can easily be inserted, and joining to the first insertion region can be easily performed.

[0143] (Aspect 7) In aspect 7, the coil includes a first coil and a second coil located closer to the base end than the first coil, the first coil includes a first main coil region and a first rear-end coil region adjacent to the first main coil region and located closer to the base end than the first main coil region, the second coil includes a second front-end coil region joined at a second insertion region and a second main coil region adjacent to the second front-end coil region and located closer to the base end than the second front-end coil region, the first coil and the second coil have the same winding direction, the coil pitch of the first rear-end coil region is wider than the coil pitch of the first main coil region, and the coil pitch of the second front-end coil region is wider than the coil pitch of the second main coil region.

[0144] According to the above-described aspect, the coil of the first rear end coil region and the coil of the second front end coil region are easily entangled, and the joining member is easily inserted, making it easy to join the first coil and the second coil.

[0145] (Aspect 8) In aspect 8, the coil includes a first coil and a second coil located closer to the base end than the first coil, and the material constituting the first coil has a higher density than the material constituting the first insertion region and the material constituting the second coil.

[0146] According to the above-described aspect, it is possible to form a region on the distal end side that is easily projected on an X-ray image using the first coil without adding other members such as an X-ray marker.

[0147] (Aspect 9) In aspect 9, the core wire has at least four insertion regions located proximal to the first insertion region, each having a frustum shape whose cross section increases toward the proximal side.

[0148] According to the above-described embodiment, it is easier to smoothly transmit twist on the base end side to the tip end side compared to an embodiment configured with a stepless taper.

[0149] (Aspect 10) In aspect 10, the at least four insertion regions include a first tapered portion, a second tapered portion closer to the base end than the first tapered portion, a third tapered portion closer to the base end than the second tapered portion, a fourth tapered portion closer to the base end than the third tapered portion, and a fifth tapered portion closer to the base end than the fourth tapered portion, wherein the taper angle of the first tapered portion is larger than the taper angle of the second tapered portion, the taper angle of the second tapered portion is larger than the taper angle of the third tapered portion, the taper angle of the third tapered portion is larger than the taper angle of the fourth tapered portion, and the taper angle of the fourth tapered portion is smaller than the taper angle of the fifth tapered portion.

[0150] According to the above-described aspect, the taper angle of the region located on the tip side of the fifth tapered portion is made smaller, and when such region is twisted or otherwise manipulated, it becomes easier to control subtle displacement on the tip side.

[0151] 10 First guide wire 11 First core wire 11a1 Eleventh insertion region 13a First straight portion 13b Bent portion 13c Second straight portion 15 First coil 15a Eleventh coil 15a1 Eleventh distal coil region 15a2 Eleventh main coil region 15a3 Eleventh proximal coil region 15b Twelfth coil 15b1 Twelfth distal coil region 15b2 Twelfth main coil region θ Predetermined angle 20 Second guide wire 21 Second core wire 21a1 Twenty-first insertion region 21a4 Twenty-fourth insertion region 21a5 Twenty-fifth insertion region 21a6 Twenty-sixth insertion region 21a8 Twenty-eighth insertion region 25 Second coil 25a Twenty-first coil 25a1 Twenty-first distal coil region 25a2 Twenty-first main coil region 25a3 Twenty-first proximal coil region 25b 22nd coil 25b1 22nd tip coil region 25b2 22nd main coil region

Claims

1. A guidewire comprising: a core wire having a first insertion region; and a coil joined to at least a portion of the first insertion region, wherein the first insertion region has a first straight portion and a bent portion adjacent to the first straight portion and located closer to the proximal end than the first straight portion, and the length of the first straight portion is 1 / 4 to 2 / 3 times the length of the bent portion.

2. The guidewire as described in claim 1, wherein the first insertion region has a second straight portion adjacent to the bent portion and located on the base end side of the bent portion, and an angle between a line parallel to the extension direction of the first straight portion and a line parallel to the extension direction of the second straight portion forms an angle of 70 degrees to 85 degrees.

3. The guidewire of claim 1, wherein said bent portion includes a rectangular parallelepiped shape formed by applying force to a broad surface.

4. The guide wire according to claim 3, wherein the rectangular parallelepiped shape is formed by pressing, and the bent portion is made of a shape memory alloy.

5. The guide wire according to claim 3, wherein the cross section of the rectangular parallelepiped is rectangular, and the length of the short side of the rectangle is 1 / 10 to 1 / 5 times the diameter of the base end side.

6. The guidewire according to claim 1, wherein the coil includes a first distal coil region that is joined at least a portion of the first insertion region, and a first main coil region that is adjacent to the first distal coil region and located on the proximal side of the first distal coil region, and the coil pitch of the first distal coil region is wider than the coil pitch of the first main coil region.

7. The guidewire according to claim 1, wherein the coil includes a first coil and a second coil located on the base end side of the first coil, the first coil includes a first main coil region and a first rear end coil region adjacent to the first main coil region and located on the base end side of the first main coil region, the second coil includes a second distal end coil region joined at a second insertion region and a second main coil region adjacent to the second distal end coil region and located on the base end side of the second distal end coil region, the first coil and the second coil have the same winding direction, the coil pitch of the first rear end coil region is wider than the coil pitch of the first main coil region, and the coil pitch of the second distal end coil region is wider than the coil pitch of the second main coil region.

8. The guidewire according to claim 1, wherein the coil includes a first coil and a second coil located closer to the base end than the first coil, and the material constituting the first coil has a higher density than the material constituting the first insertion region and the material constituting the second coil.

9. The guidewire of claim 1, wherein said core wire has at least four insertion regions proximal to said first insertion region, said insertion regions having a frustum shape whose cross section increases toward the proximal end.

10. The guidewire of claim 9, wherein the at least four insertion regions include a first tapered portion, a second tapered portion closer to the base end than the first tapered portion, a third tapered portion closer to the base end than the second tapered portion, a fourth tapered portion closer to the base end than the third tapered portion, and a fifth tapered portion closer to the base end than the fourth tapered portion, wherein a taper angle of the first tapered portion is greater than a taper angle of the second tapered portion, a taper angle of the second tapered portion is greater than a taper angle of the third tapered portion, a taper angle of the third tapered portion is greater than a taper angle of the fourth tapered portion, and a taper angle of the fourth tapered portion is smaller than a taper angle of the fifth tapered portion.

Images