Perfusion apparatus and manufacturing method therefor

Abstract

Disclosed are a perfusion apparatus and a manufacturing method therefor. The perfusion device comprises a first shell, a second shell, a first piston rod, and a second piston rod. The first shell defines, in an enclosing manner, a first flow channel and a second flow channel. The first flow channel comprises a first piston cavity, and the second flow channel comprises a second piston cavity. The second shell is connected to the first shell, and the second shell defines, in an enclosing manner, a third flow channel and a fourth flow channel. The third flow channel comprises a third piston cavity, and the fourth flow channel comprises a fourth piston cavity.

Description

Perfusion device and manufacturing method

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Chinese patent application CN202311853235.0, entitled “Infusion Device and Manufacturing Method,” filed on December 28, 2023, the entire contents of which are incorporated herein by reference. Technical Field

[0003] The present application belongs to the field of medical device technology, and in particular relates to a perfusion device and a manufacturing method. Background Art

[0004] A ventricular assist system (VAS) is an auxiliary system that can pump blood from the ventricles to other parts of the body. It is often used for patients with weak heart or heart failure and can partially or fully replace the pumping function of the ventricles.

[0005] In related technologies, the working devices of ventricular assist systems often need to be connected to a perfusion system, allowing the perfusion system to inject perfusion fluid into the working devices and extract waste fluid from the working devices. A related perfusion system uses a plunger pump to inject and extract perfusion fluid. However, existing plunger pump systems have many pipes, resulting in complex connections and cumbersome manufacturing processes. The internal pipes are prone to kinking, which can hinder the flow of perfusion fluid. Furthermore, the pipes are connected by glue, which can easily fail and cause perfusion fluid leakage, affecting product reliability. Summary of the Invention

[0006] Embodiments of the present application provide a perfusion device with a stable connection and a manufacturing method.

[0007] An embodiment of the first aspect of the present application provides a perfusion device, comprising a first housing, a second housing, a first piston rod, and a second piston rod, wherein the first housing encloses a first flow channel and a second flow channel, the first flow channel including a first piston chamber, and the second flow channel including a second piston chamber; the second housing is connected to the first housing, and the second housing encloses a third flow channel and a fourth flow channel, the third flow channel including a third piston chamber, and the fourth flow channel including a fourth piston chamber; the first piston rod is movably connected to both the first housing and the second housing, the first piston rod including a first piston head, a first connecting rod, and a second piston head arranged in sequence, at least a portion of the first piston head being located in the first piston chamber, at least a portion of the second piston head being located in the third piston chamber, and the first piston chamber and the third piston chamber being used to inject perfusion fluid into a blood pumping catheter; the second piston rod is movably connected to both the first housing and the second housing, the second piston rod including a third piston head, a second connecting rod, and a fourth piston head arranged in sequence, at least a portion of the third piston head being located in the second piston chamber, at least a portion of the fourth piston head being located in the fourth piston chamber, and the second piston chamber and the fourth piston chamber being used to aspirate perfusion fluid in the blood pumping catheter.

[0008] According to the implementation scheme of the first aspect of the present application, it also includes: a third shell, located between the first shell and the second shell, the third shell connects the first shell and the second shell, the third shell encloses to form a fifth flow channel and a sixth flow channel, the fifth flow channel is connected to the first piston chamber and the third piston chamber, and the fifth flow channel is used to connect to the blood pumping catheter; the sixth flow channel is connected to the second piston chamber and the fourth piston chamber, and the sixth flow channel is used to connect to the blood pumping catheter.

[0009] According to any of the aforementioned embodiments of the first aspect of the present application, the third shell further encloses a seventh flow channel and an eighth flow channel, the seventh flow channel is connected to both the first piston chamber and the third piston chamber, and the perfusion liquid flows into the first piston chamber or the third piston chamber through the seventh flow channel, and the eighth flow channel is connected to both the second piston chamber and the fourth piston chamber, and the perfusion liquid in the second piston chamber and the fourth piston chamber is discharged from the perfusion device through the eighth flow channel.

[0010] According to any of the aforementioned embodiments of the first aspect of the present application, the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel each include three branch flow channels that are interconnected, the three branch flow channels in the fifth flow channel are respectively connected to the first piston chamber, the third piston chamber and the blood pumping catheter, the three branch flow channels in the sixth flow channel are respectively connected to the second piston chamber, the fourth piston chamber and the blood pumping catheter, the two branch flow channels in the seventh flow channel are respectively connected to the first piston chamber and the third piston chamber, and the two branch flow channels in the eighth flow channel are respectively connected to the second piston chamber and the fourth piston chamber.

[0011] According to any of the aforementioned embodiments of the first aspect of the present application, it further includes: a unidirectional conductive element, wherein a unidirectional conductive element is provided between the first flow channel and the fifth flow channel, between the first flow channel and the seventh flow channel, between the third flow channel and the fifth flow channel, between the third flow channel and the seventh flow channel, between the second flow channel and the sixth flow channel, between the second flow channel and the eighth flow channel, between the fourth flow channel and the sixth flow channel, and between the fourth flow channel and the eighth flow channel. The unidirectional conductive element located between the seventh flow channel and the first and third flow channels is used to allow the perfusion fluid to flow only from the seventh flow channel into the first and third flow channels. The unidirectional conductive element located between the fifth flow channel and the first and third flow channels is used to allow the perfusion fluid to flow only from the first and third flow channels into the fifth flow channel. The unidirectional conductive element located between the sixth flow channel, the second flow channel, and the fourth flow channel is used to allow the perfusion fluid to flow only from the sixth flow channel into the second and fourth flow channels. The unidirectional conductive element located between the eighth flow channel, the second flow channel, and the fourth flow channel is used to allow the perfusion fluid to flow only from the second and fourth flow channels into the eighth flow channel.

[0012] According to any of the aforementioned embodiments of the first aspect of the present application, the first flow channel also includes a first branch channel and a second branch channel, the first branch channel connects the first piston chamber and the seventh flow channel, and the second branch channel connects the first piston chamber and the fifth flow channel; the second flow channel also includes a third branch channel and a fourth branch channel, the third branch channel connects the second piston chamber and the sixth flow channel, and the fourth branch channel connects the second piston chamber and the eighth flow channel; the third flow channel also includes a fifth branch channel and a sixth branch channel, the fifth branch channel connects the third piston chamber and the seventh flow channel, and the sixth branch channel connects the third piston chamber and the fifth flow channel; the fourth flow channel also includes a seventh branch channel and an eighth branch channel, the seventh branch channel connects the fourth piston chamber and the sixth flow channel, and the eighth branch channel connects the fourth piston chamber and the eighth flow channel.

[0013] According to any of the aforementioned embodiments of the first aspect of the present application, the first shell and at least one branch channel therein are prepared through an integrated molding process; the second shell and at least one branch channel therein are prepared through an integrated molding process; and the third shell and at least one branch channel therein are prepared through an integrated molding process.

[0014] According to any of the aforementioned embodiments of the first aspect of the present application, the third shell and at least one of the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are prepared by an integral molding process.

[0015] According to any of the aforementioned embodiments of the first aspect of the present application, the third shell and the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are all prepared by an integral molding process.

[0016] According to any of the aforementioned embodiments of the first aspect of the present application, the first piston chamber and the third piston chamber are spaced apart along the first direction, the second piston chamber and the fourth piston chamber are spaced apart along the first direction, and the first piston rod and the second piston rod both extend along the first direction.

[0017] According to any of the aforementioned embodiments of the first aspect of the present application, it also includes: a driving mechanism, the driving mechanism is connected to the first piston rod and the second piston rod, the driving mechanism is used to drive the first piston rod and the second piston rod to move in the first direction, thereby changing the pressure in the first piston chamber, the second piston chamber, the third piston chamber and the fourth piston chamber.

[0018] According to any of the aforementioned embodiments of the first aspect of the present application, the first shell and at least one of the first flow channel and the second flow channel therein are prepared through an integral molding process, and the second shell and at least one of the third flow channel and the fourth flow channel therein are prepared through an integral molding process.

[0019] According to any of the aforementioned embodiments of the first aspect of the present application, the first shell and the first and second flow channels therein are all prepared through an integral molding process, and the second shell and the third and fourth flow channels therein are all prepared through an integral molding process.

[0020] On the other hand, an embodiment of the present application also provides a method for manufacturing an infusion device, comprising the following steps: providing a first shell and a second shell, the first shell and the second shell are both prepared by an integral molding process, the first shell encloses a first flow channel and a second flow channel, the first flow channel includes a first piston chamber, the second flow channel includes a second piston chamber, the second shell encloses a third flow channel and a fourth flow channel, the third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; providing a first piston rod and a second piston rod, the first piston rod includes a first piston head, a first connecting rod and a second piston head arranged in sequence, the second piston rod includes a third piston head, a second connecting rod and a fourth piston head arranged in sequence; movably connecting the first piston rod and the first shell and the second shell, at least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber; movably connecting the second piston rod and the first shell and the second shell, at least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber.

[0021] According to the implementation of the second aspect of the present application, it also includes: providing a driving mechanism, and connecting the driving mechanism to the first piston rod and the second piston rod.

[0022] According to any of the aforementioned embodiments of the second aspect of the present application, it also includes: providing a third shell, the third shell is prepared by an integrated molding process, and the third shell encloses to form a fifth flow channel, a sixth flow channel, a seventh flow channel and an eighth flow channel; connecting the first shell, the second shell and the third shell, and the first shell and the second shell are located at both ends of the third shell in the first direction.

[0023] According to any of the aforementioned embodiments of the second aspect of the present application, the third shell and at least one of the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are prepared by an integral molding process.

[0024] According to any of the aforementioned embodiments of the second aspect of the present application, the third shell and the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are all prepared by an integral molding process.

[0025] According to any of the aforementioned embodiments of the second aspect of the present application, the first shell and at least one of the first flow channel and the second flow channel therein are prepared through an integral molding process, and the second shell and at least one of the third flow channel and the fourth flow channel therein are prepared through an integral molding process.

[0026] According to any of the aforementioned embodiments of the second aspect of the present application, the first shell and the first and second flow channels therein are all prepared through an integral molding process, and the second shell and the third and fourth flow channels therein are all prepared through an integral molding process.

[0027] The perfusion device of the embodiment of the present application includes a first housing, a second housing, a first piston rod and a second piston rod. The first housing encloses a first flow channel and a second flow channel, the first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber; the second housing is connected to the first housing, and the second housing encloses a third flow channel and a fourth flow channel, the third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; the first piston rod is movably connected to the first housing and the second housing, the first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence, at least a portion of the first piston head is located in the first piston chamber, at least a portion of the second piston head is located in the third piston chamber, and the first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter; the second piston rod is movably connected to the first housing and the second housing, the second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence, at least a portion of the third piston head is located in the second piston chamber, at least a portion of the fourth piston head is located in the fourth piston chamber, and the second piston chamber and the fourth piston chamber are used to aspirate perfusion fluid in the blood pumping catheter. By integrally molding the first and second shells and forming a flow channel within them, this application eliminates the need for a conduit connection within the infusion device. This prevents conduit kinking, reduces glue usage, and improves connection strength, thereby enhancing product reliability. Furthermore, the absence of a conduit within the infusion device reduces the number of pipe connection steps and improves manufacturing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0029] FIG1 is a diagram showing the connection relationship between a perfusion device and a blood pumping catheter in some embodiments of the present application;

[0030] FIG2 shows a front view of an exemplary perfusion device;

[0031] FIG3 is a schematic diagram showing the exploded structure of an exemplary perfusion device after hiding the first piston rod and the second piston rod;

[0032] FIG4 shows a top view of an exemplary perfusion device;

[0033] FIG5 shows an exemplary cross-sectional view of the filling device in FIG4 at section 00;

[0034] FIG6 shows an exemplary cross-sectional view of the filling device in FIG4 at the PP section;

[0035] FIG7 shows a cross-sectional view of an exemplary filling device in FIG4 at section QQ;

[0036] FIG8 shows a cross-sectional view of an exemplary filling device in FIG4 at section RR;

[0037] FIG9 shows a cross-sectional view of an example of the filling device in FIG4 at section VV;

[0038] FIG10 shows a bottom view of an example of a third housing;

[0039] FIG11 shows an exemplary cross-sectional view of the third housing in FIG10 taken along section GG;

[0040] FIG12 shows an example cross-sectional view of the third housing in FIG10 at section HH;

[0041] FIG13 shows a bottom view of an example of a first housing;

[0042] FIG14 shows an exemplary cross-sectional view of the first housing in FIG13 taken along section DD;

[0043] FIG15 shows an exemplary cross-sectional view of the first housing in FIG13 taken along section EE;

[0044] FIG16 shows a top view of an example of a second housing;

[0045] FIG17 shows an exemplary cross-sectional view of the second housing in FIG16 at section KK;

[0046] FIG. 18 shows an example cross-sectional view of the second shell in FIG. 16 taken along section LL.

[0047] Reference Signs: 10, perfusion device; 20, blood pumping catheter; 30, housing; 40, perfusion system; 50, discharge system; 110, first housing; 120, first flow channel; 121, first piston chamber; 122, first branch channel; 123, second branch channel; 130, second flow channel; 131, second piston chamber; 132, third branch channel; 133, fourth branch channel; 210, second housing; 220, third flow channel; 221, third piston chamber; 222, fifth branch channel; 223, sixth branch channel; 230, fourth flow channel; 231, fourth piston chamber; 232, seventh branch channel; 233, eighth branch channel; 300, first piston rod; 310, first piston head; 320, second piston head; 330, first connecting rod; 400, second piston rod; 410, third piston head; 420, fourth piston head; 430, second connecting rod; 500, driving mechanism; 510, gear; 610, third housing; 620, fifth flow channel; 630, sixth flow channel; 640, seventh flow channel; 650, eighth flow channel; 660, accommodating chamber; 670, through hole; 680, branch flow channel; 700, one-way conducting element; 800, sealing ring; x, first direction; y, second direction. DETAILED DESCRIPTION

[0048] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application, rather than to limit the present application. For those skilled in the art, the present application can be implemented without the need for some of these specific details. The following description of the embodiments is merely to provide a better understanding of the present application by illustrating the examples of the present application.

[0049] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, the elements defined by the phrase "comprising..." do not exclude the presence of other identical elements in the process, method, article, or device comprising the elements.

[0050] The applicant discovered that the numerous pipes in the prior art plunger pump system resulted in complex connections and a cumbersome manufacturing process. Furthermore, the internal pipes were prone to kinking, which could obstruct the flow of the perfusate. Furthermore, the pipes were all connected with glue, which could easily fail and cause perfusate leakage, impacting product reliability.

[0051] In view of the above problems, the applicant proposes a perfusion device, comprising a first housing, a second housing, a first piston rod, and a second piston rod. The first housing encloses a first flow channel and a second flow channel, the first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber; the second housing is connected to the first housing, and the second housing encloses a third flow channel and a fourth flow channel, the third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; the first piston rod is movably connected to the first housing and the second housing, the first piston rod includes a first piston head, a first connecting rod, and a second piston head, which are arranged in sequence, at least a portion of the first piston head is located in the first piston chamber, at least a portion of the second piston head is located in the third piston chamber, and the first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter; the second piston rod is movably connected to the first housing and the second housing, the second piston rod includes a third piston head, a second connecting rod, and a fourth piston head, which are arranged in sequence, at least a portion of the third piston head is located in the second piston chamber, at least a portion of the fourth piston head is located in the fourth piston chamber, and the second piston chamber and the fourth piston chamber are used to aspirate perfusion fluid in the blood pumping catheter.

[0052] The perfusion device provided herein utilizes an integrally formed first and second housings, with internal flow channels. This eliminates the need for internal conduit connections within the device, preventing conduit kinking while reducing glue usage and increasing connection strength, thereby enhancing product reliability. Furthermore, the absence of conduits within the device also reduces the number of pipe connection steps, improving manufacturing efficiency.

[0053] The following describes the perfusion device and manufacturing method provided by the embodiments of the present application with reference to the accompanying drawings. It should be noted that the x-direction in the accompanying drawings is the first direction, and the y-direction is the second direction. In the accompanying drawings, for ease of drawing, the dimensions in the drawings are not necessarily proportional to the actual dimensions.

[0054] Please refer to Figures 1 to 6, Figure 1 is a connection relationship diagram of the perfusion device and the blood pumping catheter in some embodiments of the present application; Figure 2 shows a front view of an example perfusion device; Figure 3 shows a schematic diagram of the decomposed structure of an example perfusion device after hiding the first piston rod and the second piston rod; Figure 4 shows a top view of an example perfusion device; Figure 5 shows an example sectional view of the filling device in Figure 4 at the OO section; Figure 6 shows an example sectional view of the filling device in Figure 4 at the PP section.

[0055] As shown in Figures 1 to 6, the present application provides a perfusion device 10 for connecting to a blood pumping catheter 20. The perfusion device 10 includes a first housing 110, a second housing 210, a first piston rod 300, and a second piston rod 400. The first housing 110 encloses a first flow channel 120 and a second flow channel 130. The first flow channel 120 includes a first piston chamber 121, and the second flow channel 130 includes a second piston chamber 131. The second housing 210 is connected to the first housing 110 and encloses a third flow channel 220 and a fourth flow channel 230. The third flow channel 220 includes a third piston chamber 221, and the fourth flow channel 230 includes a fourth piston chamber 231. The first piston rod 300 is movably connected to the second housing 210 and the first housing 110. The first piston rod 300 includes a first piston head 310, a first connecting rod 330, and a second piston head 320, which are arranged in sequence. At least a portion of the first piston head 310 is located in the first piston chamber 121, and at least a portion of the second piston head 320 is located in the third piston chamber 221. The first piston chamber 121 and the third piston chamber 221 are used to inject perfusion fluid (not shown) into the blood pumping catheter 20. The second piston rod 400 is movably connected to the second housing 210 and the first housing 110. The second piston rod 400 includes a third piston head 410, a second connecting rod 430, and a fourth piston head 420, which are arranged in sequence. At least a portion of the third piston head 410 is located in the second piston chamber 131, and at least a portion of the fourth piston head 420 is located in the fourth piston chamber 231. The second piston chamber 131 and the fourth piston chamber 231 are used to aspirate perfusion fluid from the blood pumping catheter 20.

[0056] Optionally, the first shell 110 and at least one of the first flow channel 120 and the second flow channel 130 therein are prepared through an integral molding process, and the second shell 210 and at least one of the third flow channel 220 and the fourth flow channel 230 therein are prepared through an integral molding process. Preferably, the first flow channel 120, the second flow channel 130 are all integrally molded with the first shell 110, and the third flow channel 220, the fourth flow channel 230 are all integrally molded with the second shell 210. It can be understood that after the first shell 110 and the second shell 210 are prepared through an integral molding process, the first flow channel 120 and the second flow channel 130 are already generated in the first shell 110, and the third flow channel 220 and the fourth flow channel 230 are already generated in the second shell 210. When there are flow channels in the shell that are not formed by integral injection molding with the shell, the flow channels can be processed in the shell by digging holes in the shell, etching, etc. at a later stage.

[0057] Among them, the one-piece molding process includes injection molding, compression molding and 3D printing.

[0058] Optionally, the first shell 110 and the second shell 210 are connected by connecting members such as bolts and connecting rods, or by welding, gluing, etc.

[0059] Optionally, the first piston chamber 121 and the third piston chamber 221 are spaced apart along the first direction (x direction in the figure), the second piston chamber 131 and the fourth piston chamber 231 are spaced apart along the first direction x, and the first piston rod 300 and the second piston rod 400 both extend along the first direction x.

[0060] Optionally, the first flow channel 120 and the third flow channel 220 form a perfusion system 40 for delivering perfusion fluid to the blood pumping catheter 20. The second flow channel 130 and the fourth flow channel 230 form a discharge system 50 for discharging the perfusion fluid in the blood pumping catheter 20.

[0061] The perfusion device 10 provided in this embodiment utilizes an integrally formed first housing 110 and second housing 210, creating an internal flow channel. This eliminates the need for internal conduit connections within the perfusion device 10, preventing conduit kinking while reducing glue usage and improving connection strength, thereby enhancing product reliability. Furthermore, the absence of conduits within the perfusion device reduces the number of pipe connection steps, improving manufacturing efficiency.

[0062] Please refer to Figures 1 to 9, Figure 7 shows an example cross-sectional view of the filling device in Figure 4 at the QQ section; Figure 8 shows an example cross-sectional view of the filling device in Figure 4 at the RR section; Figure 9 shows an example cross-sectional view of the filling device in Figure 4 at the VV section.

[0063] As shown in Figures 1 to 9, in some optional embodiments, the perfusion device 10 further includes a driving mechanism 500, which is connected to the first piston rod 300 and the second piston rod 400. The driving mechanism 500 is used to drive the first piston rod 300 and the second piston rod 400 to move along the first direction x, thereby changing the pressure in the first piston chamber 121, the second piston chamber 131, the third piston chamber 221 and the fourth piston chamber 231.

[0064] When the first piston rod 300 moves toward the first piston chamber 121, the first piston head 310 squeezes the first piston chamber 121, causing the pressure in the first piston chamber 121 to increase, and the perfusate in the first piston chamber 121 is pressed into the blood pumping catheter 20. At the same time, the movement of the second piston head 320 increases the volume and reduces the pressure in the third piston chamber 221, causing the perfusate to be drawn into the third piston chamber 221. When the first piston rod 300 moves toward the third piston chamber 221, the second piston head 320 squeezes the third piston chamber 221, causing the pressure in the third piston chamber 221 to increase, and the perfusate in the third piston chamber 221 is pressed into the blood pumping catheter 20. At the same time, the movement of the first piston head 310 increases the volume and reduces the pressure in the first piston chamber 121, causing the perfusate to be drawn into the first piston chamber 121.

[0065] When the second piston rod 400 moves toward the second piston chamber 131, the third piston head 410 squeezes the second piston chamber 131, causing the pressure in the second piston chamber 131 to increase and the perfusate in the second piston chamber 131 to be squeezed out. At the same time, the movement of the fourth piston head 420 causes the volume of the fourth piston chamber 231 to increase and the pressure to decrease, and the perfusate in the blood pumping catheter 20 is drawn into the fourth piston chamber 231. When the second piston rod 400 moves toward the fourth piston chamber 231, the fourth piston head 420 squeezes the fourth piston chamber 231, causing the pressure in the fourth piston chamber 231 to increase and the perfusate in the fourth piston chamber 231 to be squeezed out. At the same time, the movement of the third piston head 410 causes the volume of the second piston chamber 131 to increase and the pressure to decrease, and the perfusate in the blood pumping catheter 20 is drawn into the second piston chamber 131.

[0066] Optionally, the drive mechanism 500 can independently drive the first piston rod 300 and the second piston rod 400. For example, the drive mechanism 500 includes two independently operated motors, and the two motors respectively drive the movement of the first piston rod 300 and the second piston rod 400. The drive mechanism 500 can also drive the first piston rod 300 and the second piston rod 400 to move in conjunction.

[0067] The perfusion device 10 provided in this embodiment utilizes a first piston rod 300 to simultaneously control the pressures in the first and third piston chambers 121, 221. Both the first and third piston chambers 121, 221 are used to deliver perfusion fluid to the blood pumping catheter 20. This ensures that when the first piston rod 300 moves, one piston chamber is always delivering perfusion fluid to the blood pumping catheter 20 while the other piston chamber is replenishing perfusion fluid, thereby ensuring uninterrupted perfusion fluid flow within the blood pumping catheter 20. The second piston rod 400 also simultaneously controls the pressures in the second and fourth piston chambers 131, 231. Both the second and fourth piston chambers 131, 231 are used to aspirate perfusion fluid from the blood pumping catheter 20. This ensures that when the second piston rod 400 moves, one piston chamber is always aspirating perfusion fluid from the blood pumping catheter 20 while the other piston chamber is discharging perfusion fluid, thereby ensuring that perfusion fluid within the blood pumping catheter 20 does not accumulate. By providing four piston chambers, arranged in groups of two, this ensures smooth perfusion fluid flow within the blood pumping catheter 20.

[0068] In some optional embodiments, the driving mechanism 500 includes a gear 510 , and the first piston rod 300 and the second piston rod 400 are both provided with a rack (not shown) meshing with the gear 510 , and the rack extends along the first direction x.

[0069] Optionally, the rack is provided on the first connecting rod 330 and the second connecting rod 430 .

[0070] Optionally, the first piston rod 300 and the second piston rod 400 are spaced apart along a second direction (the y direction in the figure), and the first piston rod 300 and the second piston rod 400 are located on either side of the gear 510 in the second direction y. The first direction x and the second direction y intersect. When the gear 510 rotates in one direction, the first piston rod 300 and the second piston rod 400 both move in the first direction x, but in opposite directions. When the gear 510 moves in the opposite direction, the first piston rod 300 and the second piston rod 400 also move in the opposite direction of the first direction x. By causing the gear 510 to rotate back and forth, the drive mechanism 500 can drive the first piston rod 300 and the second piston rod 400 to continuously reciprocate in the first direction x.

[0071] The perfusion device 10 provided in this embodiment has the first piston rod 300 and the second piston rod 400 located on either side of the gear 510, and the racks on the first piston rod 300 and the second piston rod 400 are both engaged with the gear 510. Therefore, when the gear 510 rotates, the first piston rod 300 and the second piston rod 400 are both driven by the gear 510. This allows the perfusion device 10 to continuously perfuse and aspirate the blood pumping catheter 20 without interruption, thereby ensuring the continuity of the perfusion fluid.

[0072] Please refer to Figures 1 to 12, Figure 10 shows an example of a bottom view of the third shell; Figure 11 shows an example of a cross-sectional view of the third shell in Figure 10 at the GG section; Figure 12 shows an example of a cross-sectional view of the third shell in Figure 10 at the HH section.

[0073] As shown in Figures 1 to 12, in some optional embodiments, the perfusion device 10 further includes a third housing 610, which is located between the first housing 110 and the second housing 210, connecting the first housing 110 and the second housing 210. The third housing 610 encloses a fifth flow channel 620 and a sixth flow channel 630. The fifth flow channel 620 communicates with both the first piston chamber 121 and the third piston chamber 221, and is used to connect to the blood pumping conduit 20. The sixth flow channel 630 communicates with both the second piston chamber 131 and the fourth piston chamber 231, and is used to connect to the blood pumping conduit 20.

[0074] Optionally, the third housing 610 and at least one of the fifth flow channel 620 and the sixth flow channel 630 are formed in an integrated manner. The third housing 610 is connected to the first housing 110 and the second housing 210 by bolts, connecting rods or other connectors or by welding, gluing or other methods.

[0075] The first, second, and third shells 110, 210, and 610 are each injection-molded in three sections and then joined. The runners on each of these three sections are open in the first direction x, preventing material from clogging the runners during injection molding, thereby improving the injection molding yield. Furthermore, gates connected to the runners are reserved on the first, second, and third shells 110, 210, 610 to further reduce the risk of injection material clogging the runners. After hardening and molding, the gates can be sealed with plugs.

[0076] The injection device 10 provided in this embodiment is manufactured by an integrated molding process for the first shell 110 , the second shell 210 and the third shell 610 , thereby reducing the number of internal pipelines, facilitating the manufacturing process and connection, and improving the yield rate of injection molding.

[0077] In some optional embodiments, the third housing 610 further encloses a seventh flow channel 640 and an eighth flow channel 650. The seventh flow channel 640 is in communication with both the first piston chamber 121 and the third piston chamber 221, and the perfusion fluid flows into the first piston chamber 121 or the third piston chamber 221 through the seventh flow channel 640. The eighth flow channel 650 is in communication with both the second piston chamber 131 and the fourth piston chamber 231, and the perfusion fluid in the second piston chamber 131 and the fourth piston chamber 231 is discharged from the perfusion device 10 through the eighth flow channel 650.

[0078] Optionally, the third housing 610 and at least one of the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 therein are manufactured through an integral molding process. Preferably, the third housing 610 and the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 therein are all manufactured through an integral molding process. It can be understood that after the third housing 610 is manufactured through the integral molding process, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 are already formed inside.

[0079] It can be understood that the first housing 110, the second housing 210, and the third housing 610 together constitute the housing 30 of the perfusion device 10, and the housing 30 encloses the perfusion system 40 and the drainage system 50. The perfusion system 40 includes the first flow channel 120, the third flow channel 220, the fifth flow channel 620, and the seventh flow channel 640, and the drainage system 50 includes the second flow channel 130, the fourth flow channel 230, the sixth flow channel 630, and the eighth flow channel 650.

[0080] Optionally, the fifth and sixth flow channels 620 and 630 can be connected to an external blood pumping conduit 20 via a catheter (not shown). The seventh flow channel 640 is connected to an external perfusate input, such as a water tank, and the eighth flow channel 650 is connected to an external waste fluid collection device (not shown). The external perfusate input flows into the perfusion device 10 through the seventh flow channel 640. The perfusate is then drawn into the first piston chamber 121 or the third piston chamber 221 and pressed into the fifth flow channel 620. The fifth flow channel 620 then inputs the perfusate into the blood pumping conduit 20. Waste fluid in the blood pumping conduit 20 flows back into the perfusion device 10 through the sixth flow channel 630, where it is drawn into the second piston chamber 131 or the fourth piston chamber 231 and pressed into the eighth flow channel 650, ultimately exiting the perfusion device 10 through the eighth flow channel 650.

[0081] Optionally, the third shell 610 also encloses a accommodating cavity 660 and a through hole 670, the accommodating cavity 660 is used to accommodate the driving mechanism 500, and the through hole 670 passes through the third shell 610 along the first direction x, and the through hole 670 is used to enable the first piston rod 300 and the second piston rod 400 to extend from the first shell 110 to the second shell 210.

[0082] In some optional embodiments, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 each include three interconnected branch flow channels 680. The three branch flow channels 680 in the fifth flow channel 620 are respectively connected to the first piston chamber 121, the third piston chamber 221, and the blood pumping conduit 20. The three branch flow channels 680 in the sixth flow channel 630 are respectively connected to the second piston chamber 131, the fourth piston chamber 231, and the blood pumping conduit 20. Two branch flow channels 680 in the seventh flow channel 640 are respectively connected to the first piston chamber 121 and the third piston chamber 221, and another branch flow channel 680 is used to communicate with an external perfusate input port. Two branch flow channels 680 in the eighth flow channel 650 are respectively connected to the second piston chamber 131 and the fourth piston chamber 231, and another branch flow channel 680 is used to communicate with an external waste fluid collection device.

[0083] Among them, the branch flow channel 680 is also prepared through an integrated molding process. The three interconnected branch flow channels 680 among the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 can be understood as a structure similar to a tee. That is, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 can be regarded as four tees. However, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 in this application are simultaneously formed during the injection molding of the third shell 610. Compared with the solution of connecting the finished tee and the conduit, this solution reduces the number of pipe connections, reduces the amount of glue used, and avoids internal pipe kinking.

[0084] Please refer to Figures 1 to 18, Figure 13 shows an example of a bottom view of the first shell; Figure 14 shows an example of a cross-sectional view of the first shell in Figure 13 at the DD section; Figure 15 shows an example of a cross-sectional view of the first shell in Figure 13 at the EE section; Figure 16 shows an example of a top view of the second shell; Figure 17 shows an example of a cross-sectional view of the second shell in Figure 16 at the KK section; Figure 18 shows an example of a cross-sectional view of the second shell in Figure 16 at the LL section.

[0085] As shown in Figures 1 to 18, in some optional embodiments, the first flow channel 120 further includes a first branch channel 122 and a second branch channel 123. The first branch channel 122 connects the first piston chamber 121 with the seventh flow channel 640, and the second branch channel 123 connects the first piston chamber 121 with the fifth flow channel 620. The perfusate in the seventh flow channel 640 can enter the first piston chamber 121 through the first branch channel 122 and then flow into the fifth flow channel 620 through the second branch channel 123. The second flow channel 130 further includes a third branch channel 132 and a fourth branch channel 133. The third branch channel 132 connects the second piston chamber 131 with the sixth flow channel 630, and the fourth branch channel 133 connects the second piston chamber 131 with the eighth flow channel 650. The perfusate in the sixth flow channel 630 can flow into the second piston chamber 131 through the third branch channel 132 and then flow into the eighth flow channel 650 through the fourth branch channel 133. The third flow channel 220 further includes a fifth branch channel 222 and a sixth branch channel 223. The fifth branch channel 222 connects the third piston chamber 221 and the seventh flow channel 640, while the sixth branch channel 223 connects the third piston chamber 221 and the fifth flow channel 620. The perfusate in the seventh flow channel 640 can enter the third piston chamber 221 through the fifth branch channel 222 and then flow into the fifth flow channel 620 through the sixth branch channel 223. The fourth flow channel 230 further includes a seventh branch channel 232 and an eighth branch channel 233. The seventh branch channel 232 connects the fourth piston chamber 231 and the sixth flow channel 630, while the eighth branch channel 233 connects the fourth piston chamber 231 and the eighth flow channel 650. The perfusate in the sixth flow channel 630 can flow into the fourth piston chamber 231 through the seventh branch channel 232 and then flow into the eighth flow channel 650 through the eighth branch channel 233.

[0086] Optionally, the first shell 110 and at least one branch channel therein are manufactured through an integral molding process; the second shell 210 and at least one branch channel therein are manufactured through an integral molding process; and the third shell 610 and at least one branch channel therein are manufactured through an integral molding process.

[0087] Optionally, the first branch channel 122 , the second branch channel 123 , the third branch channel 132 , the fourth branch channel 133 , the fifth branch channel 222 , the sixth branch channel 223 , the seventh branch channel 232 and the eighth branch channel 233 and the shell enclosing the branches are prepared by an integrated molding process.

[0088] In some optional embodiments, the perfusion device 10 may further include a one-way conducting element 700, and a one-way conducting element 700 is provided between the first flow channel 120 and the fifth flow channel 620, between the first flow channel 120 and the seventh flow channel 640, between the third flow channel 220 and the fifth flow channel 620, between the third flow channel 220 and the seventh flow channel 640, between the second flow channel 130 and the sixth flow channel 630, between the second flow channel 130 and the eighth flow channel 650, between the fourth flow channel 230 and the sixth flow channel 630, and between the fourth flow channel 230 and the eighth flow channel 650.

[0089] The one-way conducting element 700 located between the seventh flow channel 640 and the first and third flow channels 120, 220 is configured to allow perfusion fluid to flow only from the seventh flow channel 640 into the first and third flow channels 120, 220. The one-way conducting element 700 located between the fifth flow channel 620 and the first and third flow channels 120, 220 is configured to allow perfusion fluid to flow only from the first and third flow channels 220 into the fifth flow channel 620. The one-way conducting element 700 located between the sixth flow channel 630, the second and fourth flow channels 130, 230 is configured to allow perfusion fluid to flow only from the sixth flow channel 630 into the second and fourth flow channels 130, 230. The one-way conducting element 700 located between the eighth flow channel 650, the second and fourth flow channels 130, 230 is configured to allow perfusion fluid to flow only from the second and fourth flow channels 230 into the eighth flow channel 650.

[0090] The one-way conducting element 700 may be a one-way valve or other components capable of achieving a one-way conducting function.

[0091] Optionally, the unidirectional conducting element 700 is located between the first branch 122 and the seventh flow channel 640, between the second branch 123 and the fifth flow channel 620, between the third branch 132 and the sixth flow channel 630, between the fourth branch 133 and the eighth flow channel 650, between the fifth branch 222 and the seventh flow channel 640, between the sixth branch 223 and the fifth flow channel 620, between the seventh branch 232 and the sixth flow channel 630, and between the eighth branch 233 and the eighth flow channel 650.

[0092] Optionally, the perfusion device 10 may further include a sealing ring 800, and the first flow channel 120 and the fifth flow channel 620, the first flow channel 120 and the seventh flow channel 640, the third flow channel 220 and the fifth flow channel 620, the third flow channel 220 and the seventh flow channel 640, the second flow channel 130 and the sixth flow channel 630, the second flow channel 130 and the eighth flow channel 650, the fourth flow channel 230 and the sixth flow channel 630, and the fourth flow channel 230 and the eighth flow channel 650 are all sealed and connected by the sealing ring 800.

[0093] The embodiment of the second aspect of the present application further provides a method for manufacturing a perfusion device 10, comprising the following steps:

[0094] Step S1: Provide a first housing 110 and a second housing 210. Both the first housing 110 and the second housing 210 are manufactured through an integral molding process. The first housing 110 encloses a first flow channel 120 and a second flow channel 130. The first flow channel 120 includes a first piston chamber 121, and the second flow channel 130 includes a second piston chamber 131. The second housing 210 encloses a third flow channel 220 and a fourth flow channel 230. The third flow channel 220 includes a third piston chamber 221, and the fourth flow channel 230 includes a fourth piston chamber 231.

[0095] Step S2: providing a first piston rod 300 and a second piston rod 400, wherein the first piston rod 300 includes a first piston head 310, a first connecting rod 330, and a second piston head 320, which are sequentially arranged; and the second piston rod 400 includes a third piston head 410, a second connecting rod 430, and a fourth piston head 420, which are sequentially arranged.

[0096] Step S3, movably connecting the first piston rod 300 and the first housing 110 and the second housing 210, so that at least a portion of the first piston head 310 is located in the first piston chamber 121, and at least a portion of the second piston head 320 is located in the third piston chamber 221;

[0097] Step S4 , movably connecting the second piston rod 400 and the first housing 110 and the second housing 210 , at least a portion of the third piston head 410 is located in the second piston chamber 131 , and at least a portion of the fourth piston head 420 is located in the fourth piston chamber 231 .

[0098] Since the manufacturing method of the perfusion device 10 provided in the second aspect embodiment of the present application is used to manufacture the perfusion device 10 of any embodiment of the first aspect above, the manufacturing method of the perfusion device 10 provided in the second aspect embodiment of the present application has the beneficial effects of the perfusion device 10 of any embodiment of the first aspect above, and will not be repeated here.

[0099] In some optional embodiments, the method for manufacturing the perfusion device 10 further includes the following steps:

[0100] Step S5 , providing a driving mechanism 500 , and connecting the driving mechanism 500 to the first piston rod 300 and the second piston rod 400 .

[0101] Optionally, step S5 is performed after step S4.

[0102] In some optional embodiments, the method for manufacturing the perfusion device 10 further includes the following steps:

[0103] Step S6, providing a third housing 610, which is manufactured by an integrated molding process. The third housing 610 encloses a fifth flow channel 620, a sixth flow channel 630, a seventh flow channel 640, and an eighth flow channel 650;

[0104] Step S7 : connecting the first shell 110 , the second shell 210 and the third shell 610 . The first shell 110 and the second shell 210 are located at two ends of the third shell 610 in the first direction x.

[0105] The first shell, the second shell and the third shell are connected, and the first shell and the second shell are located at two ends of the third shell in a first direction.

[0106] Optionally, step S6 is located after step S5.

[0107] The above description is only a specific embodiment of the present application. Those skilled in the art will clearly understand that for the convenience and brevity of description, the specific working processes of the systems, modules and units described above can refer to the corresponding processes in the aforementioned method embodiments, and will not be repeated here. It should be understood that the scope of protection of the present application is not limited thereto. Any person skilled in the art can easily think of various equivalent modifications or replacements within the technical scope disclosed in the present application, and these modifications or replacements should be included in the scope of protection of the present application.

Claims

1. An infusion device for connection to a blood pumping catheter, wherein, Comprising: A first housing which encloses and forms a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber; A second housing connected to the first housing. The second housing encloses and forms a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; A first piston rod movably connected to both the first housing and the second housing. The first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber. The first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter; A second piston rod movably connected to both the first housing and the second housing. The second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber. The second piston chamber and the fourth piston chamber are used to suck the perfusion fluid in the blood pumping catheter.

2. The perfusion device according to claim 1, wherein, Further comprising: A third housing located between the first housing and the second housing. The third housing connects the first housing and the second housing. The third housing encloses and forms a fifth flow channel and a sixth flow channel. The fifth flow channel is communicated with both the first piston chamber and the third piston chamber, and the fifth flow channel is used to communicate with the blood pumping catheter; the sixth flow channel is communicated with both the second piston chamber and the fourth piston chamber, and the sixth flow channel is used to communicate with the blood pumping catheter.

3. The perfusion device according to claim 2, wherein, The third housing also encloses and forms a seventh flow channel and an eighth flow channel. The seventh flow channel is communicated with both the first piston chamber and the third piston chamber, and the perfusion fluid flows into the first piston chamber or the third piston chamber through the seventh flow channel. The eighth flow channel is communicated with both the second piston chamber and the fourth piston chamber, and the perfusion fluid in the second piston chamber and the fourth piston chamber is discharged from the perfusion device through the eighth flow channel.

4. The perfusion device according to claim 3, wherein, The fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel each include three mutually connected branch flow channels. The three branch flow channels in the fifth flow channel are respectively communicated with the first piston chamber, the third piston chamber, and the blood pumping catheter. The three branch flow channels in the sixth flow channel are respectively communicated with the second piston chamber, the fourth piston chamber, and the blood pumping catheter. The two branch flow channels in the seventh flow channel are respectively communicated with the first piston chamber and the third piston chamber. The two branch flow channels in the eighth flow channel are respectively communicated with the second piston chamber and the fourth piston chamber.

5. The perfusion device according to claim 3, wherein, Further comprising: One-way conduction elements are provided between the first flow channel and the fifth flow channel, between the first flow channel and the seventh flow channel, between the third flow channel and the fifth flow channel, between the third flow channel and the seventh flow channel, between the second flow channel and the sixth flow channel, between the second flow channel and the eighth flow channel, between the fourth flow channel and the sixth flow channel, and between the fourth flow channel and the eighth flow channel. The one-way conduction elements located between the seventh flow channel and the first flow channel and the third flow channel are used to allow the perfusion liquid to only flow from the seventh flow channel into the first flow channel and the third flow channel. The one-way conduction elements located between the fifth flow channel and the first flow channel and the third flow channel are used to allow the perfusion liquid to only flow from the first flow channel and the third flow channel into the fifth flow channel. The one-way conduction elements located between the sixth flow channel and the second flow channel and the fourth flow channel are used to allow the perfusion liquid to only flow from the sixth flow channel into the second flow channel and the fourth flow channel. The one-way conduction elements located between the eighth flow channel and the second flow channel and the fourth flow channel are used to allow the perfusion liquid to only flow from the second flow channel and the fourth flow channel into the eighth flow channel.

6. The perfusion device according to claim 3, wherein, The first flow channel further includes a first branch channel and a second branch channel. The first branch channel connects the first piston chamber and the seventh flow channel, and the second branch channel connects the first piston chamber and the fifth flow channel. The second flow channel further includes a third branch channel and a fourth branch channel. The third branch channel connects the second piston chamber and the sixth flow channel, and the fourth branch channel connects the second piston chamber and the eighth flow channel. The third flow channel further includes a fifth branch channel and a sixth branch channel. The fifth branch channel connects the third piston chamber and the seventh flow channel, and the sixth branch channel connects the third piston chamber and the fifth flow channel. The fourth flow channel further includes a seventh branch channel and an eighth branch channel. The seventh branch channel connects the fourth piston chamber and the sixth flow channel, and the eighth branch channel connects the fourth piston chamber and the eighth flow channel.

7. The perfusion device according to claim 6, wherein, The first housing and at least one of its internal branch channels are prepared by an integral molding process; the second housing and at least one of its internal branch channels are prepared by an integral molding process; the third housing and at least one of its internal branch channels are prepared by an integral molding process.

8. The perfusion device according to claim 3, wherein, The third housing and at least one of the fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel therein are prepared by an integral molding process.

9. The perfusion device according to claim 8, wherein, The third housing and the fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel therein are all prepared by an integral molding process.

10. The perfusion device according to claim 1, wherein, The first piston chamber and the third piston chamber are spaced apart along a first direction, the second piston chamber and the fourth piston chamber are spaced apart along the first direction, and both the first piston rod and the second piston rod extend along the first direction.

11. The perfusion device according to claim 10, wherein, Further included: A driving mechanism, which is connected to the first piston rod and the second piston rod, and is used to drive the first piston rod and the second piston rod to move along the first direction, thereby changing the pressures in the first piston chamber, the second piston chamber, the third piston chamber and the fourth piston chamber.

12. The perfusion device according to claim 1, wherein, The first housing and at least one of the first flow channel and the second flow channel therein are prepared by an integral molding process, and the second housing and at least one of the third flow channel and the fourth flow channel therein are prepared by an integral molding process.

13. The perfusion device according to claim 1, wherein, The first housing and both the first flow channel and the second flow channel therein are prepared by an integral molding process, and the second housing and both the third flow channel and the fourth flow channel therein are prepared by an integral molding process.

14. A manufacturing method of a perfusion device, wherein, The method includes the following steps: Provide a first housing and a second housing, both of which are prepared by an integral molding process. The first housing encloses a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber. The second housing encloses a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; Provide a first piston rod and a second piston rod. The first piston rod includes a first piston head, a first connecting rod and a second piston head arranged in sequence, and the second piston rod includes a third piston head, a second connecting rod and a fourth piston head arranged in sequence; Actively connect the first piston rod to the first housing and the second housing. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber; Actively connect the second piston rod to the first housing and the second housing. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber.

15. The manufacturing method of the perfusion device according to claim 14, wherein, It further includes: Provide a driving mechanism and connect the driving mechanism to the first piston rod and the second piston rod.

16. The manufacturing method of the perfusion device according to claim 14, wherein, It further includes: Provide a third housing, which is prepared by an integral molding process. The third housing encloses a fifth flow channel, a sixth flow channel, a seventh flow channel and an eighth flow channel; Connect the first housing, the second housing and the third housing. The first housing and the second housing are located at both ends of the third housing in the first direction.

17. The manufacturing method of the perfusion device according to claim 16, wherein, The third housing and at least one of the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are prepared by an integral molding process.

18. The manufacturing method of the perfusion device according to claim 17, wherein, The third housing and all of the fifth flow channel, the sixth flow channel, the seventh flow channel and the eighth flow channel therein are prepared by an integral molding process.

19. The manufacturing method of the perfusion device according to claim 14, wherein, The first housing and at least one of the first flow channel and the second flow channel therein are prepared by an integral molding process, and the second housing and at least one of the third flow channel and the fourth flow channel therein are prepared by an integral molding process.

20. The manufacturing method of the perfusion device according to claim 19, wherein, The first housing and the first flow channel and the second flow channel therein are all prepared by an integral molding process, and the second housing and the third flow channel and the fourth flow channel therein are all prepared by an integral molding process.

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