Sample analysis system, liquid chromatography device, and control method for liquid chromatography device

Abstract

Provided are a sample analysis system (10), a liquid chromatography device, and a control method for the liquid chromatography device. The sample analysis system (10) comprises a liquid chromatography analyzer (100), a hematology analyzer (200), a sample transfer apparatus (300), and a control assembly (500). The liquid chromatography analyzer (100) comprises a sample supply assembly (110), a liquid-phase fluid supply assembly (120), a reversing valve (130), a reagent preparation channel (140), a chromatographic column (150), and a detector (160). The liquid-phase fluid supply assembly (120) comprises a first driving device (121), an energy storage device (122), and a locking / releasing device (123). The control assembly (500) is configured to: within a first preset period after a chromatographic analysis project on a blood sample is completed, if no information about other blood samples requiring to undergo the chromatographic analysis project is received, control the locking / releasing device (123) to switch to a locked state so as to prevent a potential energy storage and release assembly (1222) from releasing stored potential energy. The present invention solves the technical problems of low liquid-phase fluid utilization efficiency and low detection speed of the liquid chromatography device in an intermittent sample loading scenario.

Description

Sample analysis system, liquid chromatography equipment and control method thereof Technical Field

[0001] The present application relates to the field of in vitro diagnostic equipment, and in particular to a sample analysis system, a liquid chromatography device, and a control method for a liquid chromatography device. Background Art

[0002] The normal working process of a liquid chromatography analyzer provided by the related technology is: first, the pressure of the liquid phase fluid is driven by the driving device to reach the target pressure value or target pressure range to achieve pressure building, and then the chromatography analysis project is started. After the chromatography analysis project is completed, if there is no sample to perform the chromatography analysis project, the driving device is stopped to achieve pressure relief.

[0003] When the above-mentioned liquid chromatograph is applied to a scenario requiring frequent intermittent injection, the liquid circuit system needs to frequently repeat the process of pressure building, executing chromatographic analysis items, and pressure relief, which leads to the following problems in the specific application of the liquid chromatograph: (1) Frequent pressure building and pressure relief will lead to loss of liquid phase fluid, thereby resulting in relatively low utilization efficiency of liquid phase fluid; (2) The pressure building process takes a long time, and repeated pressure building leads to a relatively slow detection speed of the liquid chromatograph in the scenario of intermittent injection, making it difficult for the liquid chromatograph to be used online with analyzers of other analysis items, because when the liquid chromatograph is connected to other analyzers, the pressure building process will cause the sample to be stuck on the track, thereby blocking the sample transmission channel of other analyzers, thereby reducing the detection efficiency of the sample. Based on this, the liquid chromatograph is generally operated in a stand-alone mode, and it is recommended that the operator concentrate on injecting samples on the liquid chromatograph stand-alone to reduce the process of pressure building and pressure relief. In this way, it will take a long time for the chromatographic analysis items of some samples to issue test reports, which is likely to cause patient dissatisfaction. Summary of the Invention

[0004] The first purpose of the present application is to provide a sample analysis system, which aims to solve the technical problems of low liquid phase fluid utilization efficiency and slow detection speed when the liquid chromatograph is used in the intermittent sampling scenario in the related art.

[0005] To achieve the above objectives, the present application provides a solution: a sample analysis system comprising:

[0006] A sample input device, the sample input device is at least used for receiving a sample container loaded with a blood sample to achieve the loading of the blood sample;

[0007] a liquid chromatography analyzer, configured to draw a blood sample from a sample container and perform a chromatographic analysis on at least a portion of the drawn blood sample;

[0008] a blood cell analyzer for drawing a blood sample from a sample container and performing a blood cell analysis on at least a portion of the drawn blood sample;

[0009] A sample transfer device, the sample transfer device comprising a first transfer track and a second transfer track, the first transfer track being used to transfer the sample container from the sample input device to the liquid chromatograph analyzer, the second transfer track being used to transfer the sample container from the sample input device to the hematology analyzer, the first transfer track and the second transfer track being integrally formed or interconnected;

[0010] An information acquisition device, the information acquisition device is used to acquire information representing the type of the item to be tested of the blood sample in the sample container;

[0011] a control component configured to: determine the type of the item to be tested of the blood sample in the sample container based on the information characterizing the type of the item to be tested of the blood sample in the sample container fed back by the information acquisition device; and control the sample transfer device to transfer the sample container to the liquid chromatograph and / or the blood cell analyzer for sample aspiration based on the type of the item to be tested of the blood sample in the sample container;

[0012] The liquid chromatograph analyzer includes a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, and a detector. The chromatographic column is connected between the reversing valve and the detector. The reversing valve has a switchable first connection state and a second connection state: in the first connection state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second connection state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column.

[0013] The sample supply assembly is used to draw a blood sample from a sample container and supply a test solution made from at least a portion of the drawn blood sample to the test solution preparation channel via the reversing valve;

[0014] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0015] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0016] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0017] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. At least a portion of the potential energy storage and release assembly is capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release stored potential energy.

[0018] The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing the potential energy storage and release component from moving relative to the housing, thereby preventing the potential energy storage and release component from releasing stored potential energy; in the released state, the potential energy storage and release component can move relative to the housing under the pressure of the liquid fluid to store potential energy; and, when the locking and releasing device removes the force applied to the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the housing, thereby allowing the potential energy storage and release component to release stored potential energy;

[0019] The control component is further configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release component to move relative to the housing to store potential energy under the pressure of the liquid-phase fluid; within a first preset time period after completing a chromatographic analysis project for a blood sample, if no information is obtained that other blood samples need to be subjected to chromatographic analysis projects, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release component from moving relative to the housing, thereby preventing the potential energy storage and release component from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device is switched to the locked state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, control the locking and releasing device to switch from the locked state to the released state, allowing the potential energy storage and release component to move relative to the housing to release the stored potential energy, thereby assisting in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

[0020] A second object of the present application is to provide a sample analysis system, the sample analysis system comprising:

[0021] A sample input device, the sample input device is at least used for receiving a sample container loaded with a blood sample to achieve the loading of the blood sample;

[0022] a liquid chromatography analyzer, configured to draw a blood sample from a sample container and perform a chromatographic analysis on at least a portion of the drawn blood sample;

[0023] a blood cell analyzer for drawing a blood sample from a sample container and performing a blood cell analysis on at least a portion of the drawn blood sample;

[0024] A sample transfer device, the sample transfer device comprising a first transfer track and a second transfer track, the first transfer track being used to transfer the sample container from the sample input device to the liquid chromatograph analyzer, the second transfer track being used to transfer the sample container from the sample input device to the hematology analyzer, the first transfer track and the second transfer track being integrally formed or interconnected;

[0025] An information acquisition device, the information acquisition device is used to acquire information representing the type of the item to be tested of the blood sample in the sample container;

[0026] a control component configured to: determine the type of the item to be tested of the blood sample in the sample container based on the information characterizing the type of the item to be tested of the blood sample in the sample container fed back by the information acquisition device; and control the sample transfer device to transfer the sample container to the liquid chromatograph and / or the blood cell analyzer for sample aspiration based on the type of the item to be tested of the blood sample in the sample container;

[0027] The liquid chromatograph analyzer includes a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, and a detector. The reversing valve has a switchable first connection state and a second connection state: in the first connection state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second connection state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column, and the chromatographic column is connected between the reversing valve and the detector.

[0028] The sample supply assembly is used to draw a blood sample from a sample container and supply a test solution made from at least a portion of the drawn blood sample to the test solution preparation channel via the reversing valve;

[0029] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0030] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0031] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0032] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. The potential energy storage and release assembly is at least partially movable relative to the housing to change the size of the liquid cavity and store or release potential energy. The lock-and-release device is switchable between a locked state and a released state.

[0033] The control component is further configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release component to move relative to the housing under the pressure of the liquid-phase fluid to store potential energy; within a first preset time period after completing a chromatographic analysis project for a blood sample, if no information is obtained that other blood samples need to be subjected to chromatographic analysis projects, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release component from moving relative to the housing to prevent it from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow;

[0034] When the lock-and-release device is in the locked state and the reversing valve is in the first connected state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, the sample supply assembly is controlled to perform the following test solution preparation actions: aspirating the blood sample from the sample container and dispensing it into the first reaction container, and transferring the test solution composed of at least the blood sample and a hemolytic agent in the first reaction container to the sample preparation channel through the reversing valve;

[0035] During the process of the sample supply assembly performing the test solution preparation action, the first driving device is controlled to start and operate, and the locking and releasing device is controlled to switch from the locking state to the releasing state, so that the potential energy storage and release assembly moves relative to the housing to release the stored potential energy, thereby assisting in driving the liquid phase fluid to flow toward the reversing valve and the chromatographic column;

[0036] After the sample supply assembly completes the test solution preparation action, the reversing valve is controlled to switch from the first connection state to the second connection state, so that the liquid-phase fluid supply assembly drives the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid.

[0037] A third object of the present application is to provide a liquid chromatography device, comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller, wherein the chromatographic column is connected between the reversing valve and the detector, and the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column;

[0038] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0039] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0040] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0041] The detector is used to analyze the liquid to be tested flowing out of the chromatographic column;

[0042] The liquid-phase fluid supply assembly includes a first driving device and an energy storage device, wherein the first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column, and the energy storage device is provided between the first driving device and the reversing valve, and is used to store potential energy or release the stored potential energy;

[0043] The first controller is configured to: during the execution of a chromatographic analysis project for a sample, control the first driving device to drive the liquid-phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column, and control the energy storage device to store potential energy through the pressure of the liquid-phase fluid; after completing the chromatographic analysis project for the sample and when executing the chromatographic analysis project for the next sample, control the energy storage device to release the potential energy stored during the execution of the chromatographic analysis project for the sample, so as to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

[0044] A fourth object of the present application is to provide a liquid chromatography device, comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller, wherein the chromatographic column is connected between the reversing valve and the detector, and the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column;

[0045] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0046] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0047] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0048] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0049] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. At least a portion of the potential energy storage and release assembly is capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release stored potential energy.

[0050] The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device abuts against the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing it from moving relative to the housing, thereby preventing the potential energy storage and release component from releasing stored potential energy; in the released state, the potential energy storage and release component can move relative to the housing under the pressure of the liquid fluid to store potential energy; and, when the locking and releasing device is disengaged from the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the housing, thereby allowing the potential energy storage and release component to release stored potential energy;

[0051] The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state so as to allow the potential energy storage and release component to move relative to the shell to store potential energy through the pressure of the liquid-phase fluid; within a first preset time period after completing a chromatographic analysis project for a sample, if no information is obtained that other samples need to perform chromatographic analysis projects, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release component from moving relative to the shell to prevent it from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device is switched to the locked state, if information is obtained that a sample needs to perform a chromatographic analysis project, control the locking and releasing device to switch from the locked state to the released state so that the potential energy storage and release component can move relative to the shell to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

[0052] A fifth object of the present application is to provide a liquid chromatography device, the liquid chromatography device comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller, wherein the chromatographic column is connected between the reversing valve and the detector, and the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column;

[0053] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0054] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0055] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0056] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0057] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. At least a portion of the potential energy storage and release assembly is capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release stored potential energy.

[0058] The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device locks the potential energy storage and release component by a non-liquid path locking method, thereby preventing it from moving relative to the housing, thereby preventing the potential energy storage and release component from releasing stored potential energy; in the released state, the potential energy storage and release component can move relative to the housing under the pressure of the liquid phase fluid to store potential energy, and the locking and releasing device releases the potential energy storage and release component by a non-liquid path conduction method, thereby allowing the potential energy storage and release component to release the stored potential energy;

[0059] The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state so as to allow the potential energy storage and release component to move relative to the shell to store potential energy through the pressure of the liquid-phase fluid; within a first preset time period after completing a chromatographic analysis project for a sample, if no information is obtained that other samples need to perform chromatographic analysis projects, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release component from moving relative to the shell to prevent it from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device is switched to the locked state, if information is obtained that a sample needs to perform a chromatographic analysis project, control the locking and releasing device to switch from the locked state to the released state so that the potential energy storage and release component can move relative to the shell to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

[0060] A sixth object of the present application is to provide a liquid chromatography device, the liquid chromatography device comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller, wherein the chromatographic column is connected between the reversing valve and the detector, and the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column;

[0061] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0062] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0063] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0064] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0065] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage-and-release assembly. The potential energy storage-and-release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. The housing is formed with a liquid inlet for the liquid-phase fluid to flow into the liquid cavity and a liquid outlet for the liquid-phase fluid to flow out of the liquid cavity. At least a portion of the potential energy storage-and-release assembly is capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release stored potential energy.

[0066] The locking and releasing device can be switched between a locked state and a released state: in the locked state, the locking and releasing device prevents the potential energy storage and release component from releasing the stored potential energy; in the released state, the locking and releasing device allows the potential energy storage and release component to store potential energy and release the stored potential energy;

[0067] The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid phase fluid to flow at a target pressure value or a pressure value within a target pressure range to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release component to move relative to the shell under the pressure of the liquid phase fluid to store potential energy; within a first preset time after completing a chromatographic analysis project for a sample, if no other sample is obtained that needs to perform a chromatographic analysis project, then control the locking and releasing device from the released state Switching to the locked state to prevent the potential energy storage and release component from moving relative to the housing, thereby preventing it from releasing the stored potential energy, controlling the first driving device to stop driving the liquid-phase fluid to flow, so that the pressure of the liquid-phase fluid at the liquid outlet is maintained at a first pressure value; when the lock-release device is in the locked state, if information is obtained that a sample needs to be subjected to a chromatographic analysis project, controlling the lock-release device to switch from the locked state to the released state, so that the potential energy storage and release component can move relative to the housing to release the stored potential energy, thereby assisting in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column;

[0068] The first pressure value is substantially equal to the target pressure value or within the target pressure range, or the first pressure value is substantially equal to zero.

[0069] A seventh object of the present application is to provide a liquid chromatography device, the liquid chromatography device comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller, wherein the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column, and the chromatographic column is connected between the reversing valve and the detector;

[0070] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0071] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0072] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0073] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0074] The liquid-phase fluid supply assembly includes a first driving device, a second driving device, and an energy storage device. The first driving device is connected between the liquid-phase fluid container and the energy storage device, and is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is used to store potential energy when the first driving device drives the liquid-phase fluid to flow. The second driving device is connected to the liquid-phase fluid container and / or the energy storage device, and is used to suck the liquid-phase fluid for storage and use the stored liquid-phase fluid to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

[0075] The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column; within a first preset time period after completing a chromatographic analysis project for a sample, if no information is obtained that there are other samples that need to perform chromatographic analysis projects, control the second driving device to start and run to aspirate the liquid-phase fluid and store it in the second driving device, and control the first driving device to stop driving the liquid-phase fluid to flow; after the second driving device stores the liquid-phase fluid, if information is obtained that there are samples that need to perform chromatographic analysis projects, control the first driving device to start and run to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column, and control the second driving device to start and run to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column through the stored liquid-phase fluid.

[0076] An eighth object of the present application is to provide a liquid chromatography device, the liquid chromatography device comprising a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, and a detector, wherein the chromatographic column is connected between the reversing valve and the detector, and the reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column;

[0077] The sample supply assembly is used to supply a test liquid made of at least a sample to the test liquid preparation channel via the reversing valve;

[0078] The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence;

[0079] The chromatographic column is used to adsorb the test solution and to allow the liquid phase fluid to elute the test solution to form a test solution;

[0080] The detector is used to perform chromatographic analysis on the liquid to be tested flowing out of the chromatographic column;

[0081] The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a lock-and-release device. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatographic column. The energy storage device is disposed between the first driving device and the reversing valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and is separated within the housing to form a liquid cavity for the liquid-phase fluid to flow through. At least a portion of the potential energy storage and release assembly is capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release stored potential energy.

[0082] The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can store potential energy by moving relative to the shell through the pressure of the fluid, and, when the locking and releasing device removes the force applied to the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the shell, so as to allow the potential energy storage and release component to release the stored potential energy.

[0083] A ninth object of the present application is to provide a sample analysis system, the sample analysis system comprising:

[0084] A sample input device, the sample input device is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0085] a first analyzer, wherein the first analyzer is the aforementioned liquid chromatography device, the liquid chromatography device being used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0086] a second analyzer, the second analyzer being configured to draw a sample from a sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0087] A sample transfer device, the sample transfer device comprising a first transfer track and a second transfer track, the first transfer track being used to transfer the sample container from the sample input device to the liquid chromatography device, the second transfer track being used to transfer the sample container from the sample input device to the cell analyzer, the first transfer track and the second transfer track being integrally formed or interconnected;

[0088] The control component is configured to: according to the type of the test item of the sample in the sample container, control the sample transmission device to transmit the sample container to the first analyzer and / or the second analyzer for sample aspiration.

[0089] A tenth object of the present application is to provide a control method for a liquid chromatography device, the control method comprising the following steps:

[0090] Within a first preset time period after completing a chromatographic analysis project for a blood sample, if no information is obtained that another blood sample needs to be subjected to a chromatographic analysis project, the locking and releasing device is controlled to switch from a released state to a locked state to prevent the potential energy storage and release component from releasing stored potential energy, and the first driving device is controlled to stop driving the liquid phase fluid to flow;

[0091] After the locking and releasing device is switched to the locking state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, the locking and releasing device is controlled to switch from the locking state to the releasing state, so that the potential energy storage and release component releases the stored potential energy to assist in driving the liquid phase fluid to flow toward the chromatographic column.

[0092] As an embodiment, the control method further includes: before executing a first chromatographic analysis project after the liquid chromatograph is powered on, controlling the first driving device to start and keep running for a third preset time period so that the pressure of the liquid phase fluid flowing to the chromatographic column reaches a target pressure value or a target pressure range; during the execution of the chromatographic analysis project, controlling the first driving device to drive the liquid phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column;

[0093] If information is obtained that a chromatographic analysis project needs to be performed on a blood sample, controlling the lock-and-release device to switch from the locked state to the released state includes: first controlling the first driving device to start and keep running for a second preset time period so that the pressure of the liquid phase fluid flowing to the chromatographic column is greater than zero and less than the target pressure value or less than the lower limit of the target pressure range, and then controlling the lock-and-release device to switch from the locked state to the released state;

[0094] The control method further includes: after controlling the lock-release device to switch from the locked state to the released state, first controlling the first driving device to continue to operate for a fourth preset time period so that the pressure of the liquid-phase fluid flowing to the chromatographic column approximately reaches the target pressure value or the target pressure range, and then controlling the reversing valve to switch to a state connecting the liquid-phase fluid supply assembly, the test liquid preparation channel, and the chromatographic column, so that the liquid-phase fluid supply assembly drives the test liquid in the test liquid preparation channel to be delivered to the chromatographic column through the liquid-phase fluid;

[0095] The sum of the second preset time length and the fourth preset time length is less than the third preset time length.

[0096] An eleventh object of the present application is to provide a method for controlling a liquid chromatography device, the method comprising the following steps:

[0097] During a chromatographic analysis of a sample, the first driving device is controlled to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column and composed of at least the sample, and the energy storage device is controlled to store potential energy through the pressure of the liquid phase fluid.

[0098] After completing the chromatographic analysis project of the one sample and when executing the chromatographic analysis project of the next sample, the energy storage device is controlled to release the potential energy stored in the process of executing the chromatographic analysis project of the one sample to assist in driving the liquid phase fluid to flow toward the reversing valve and the chromatographic column.

[0099] The sample analysis system, liquid chromatography equipment and control method of the liquid chromatography equipment provided by the present application are provided with an energy storage device and a lock-and-release device in a liquid-phase fluid supply component, the lock-and-release device is provided to release the potential energy storage and release component of the energy storage device in a released state to allow the energy storage device to store potential energy and release potential energy under the pressure of the liquid-phase fluid, and the lock-and-release device is provided to lock the potential energy storage and release component in a locked state to prevent the energy storage device from releasing the stored potential energy, so that the liquid-phase fluid supply component has the function of storing and releasing potential energy in addition to the function of providing liquid-phase fluid of a certain pressure. The potential energy stored in the energy storage device can be used to reduce the energy loss in the intermittent sampling scenario, and the potential energy released by the energy storage device can be used to assist in the rapid pressure building of the liquid-phase fluid, thereby accelerating the speed of re-building pressure in the intermittent sampling scenario. Specifically, within the first preset time period after completing a chromatographic analysis project for a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, the present application controls the locking and releasing device to lock the potential energy storage and release component to prevent the potential energy storage and release component from releasing the stored potential energy, and controls the first driving component of the liquid-phase fluid supply component to stop running; when information is obtained again that there is a blood sample that needs to perform a chromatographic analysis project, the locking and releasing device is controlled to release the potential energy storage and release component so that the potential energy storage and release component assists in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column by releasing the stored potential energy, thereby reducing energy loss through the potential energy stored in the energy storage device, and accelerating the speed of re-pressure building through the potential energy released by the energy storage device. Applying the solution of the present application to the scenario of intermittent sampling can avoid the problem that the samples of intermittent sampling need to wait for a long time to build pressure before entering the liquid chromatograph for analysis, so that each chromatographic analysis project can quickly produce a test report, and when the liquid chromatograph is used online with other analyzers, the transmission track will not be blocked due to the long queue of samples of the liquid chromatograph, affecting the sample transmission of other analyzers, thereby fully ensuring the detection efficiency of samples in the online state. In addition, when the lock-release device locks the potential energy storage and release component, since the first drive device for driving the flow of the liquid phase fluid in the liquid phase fluid supply component is in a stopped state, it avoids the undesirable phenomenon of the first drive device continuing to run when there is no sample to be tested, resulting in the loss and waste of liquid phase fluid. BRIEF DESCRIPTION OF THE DRAWINGS

[0100] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.

[0101] FIG1 is a schematic structural diagram of a sample analysis system provided in Example 1 of the present application;

[0102] FIG2 is a schematic diagram of the composition of a sample analysis system provided in Example 1 of the present application;

[0103] 3 is a schematic diagram of the liquid path of the liquid chromatograph provided in Example 1 of the present application when the reversing valve is in a first connected state;

[0104] 4 is a schematic diagram of the liquid circuit of the liquid chromatograph provided in Example 1 of the present application when the reversing valve is in the second connection state;

[0105] 5 is a cross-sectional schematic diagram of the energy storage device and the lock-release device provided in Example 1 of the present application in an initial state;

[0106] 6 is a cross-sectional schematic diagram of the energy storage device and the lock-release device provided in Example 1 of the present application when performing a chromatographic analysis project;

[0107] 7 is a cross-sectional schematic diagram of the lock-release device provided in Example 1 of the present application in a state where the energy storage device is locked;

[0108] FIG8 is a schematic diagram of the external structure of the energy storage device provided in Example 1 of the present application;

[0109] FIG9 is a cross-sectional schematic diagram of the energy storage device provided in Example 1 of the present application;

[0110] FIG10 is a perspective schematic diagram of a liquid chromatography analyzer provided in Example 1 of the present application;

[0111] FIG11 is a schematic diagram of the structure of a liquid chromatography-mass spectrometry analyzer provided in Example 1 of the present application;

[0112] 12 is a schematic diagram of the liquid path of the liquid chromatograph analyzer provided in Example 6 of the present application when the reversing valve is in a first connected state;

[0113] Figure 13 is a schematic diagram of the liquid path of the liquid chromatograph analyzer provided in Example 7 of the present application when the reversing valve is in the first connected state.

[0114] Description of the accompanying drawings: 10, sample analysis system; 100, liquid chromatograph; 110, sample supply assembly; 111, sampling component; 112, first reaction container; 113, sample delivery line; 120, liquid phase fluid supply assembly; 121, first driving device; 122, energy storage device; 1221, housing; 1221a, liquid inlet; 1221b, liquid outlet; 1222, potential energy storage and release assembly; 122 2a, diaphragm; 1222b, elastic element; 1222c, guide rod; 1222d, latching portion; 1223, liquid chamber; 123, locking and releasing device; 1231, power component; 1232, locking component; 1232a, locking portion; 1233, transmission component; 1234, detection component; 1235, two-way valve; 124, third driving component; 125, mixing component; 126, second driving component; 130 , reversing valve; 140, test solution preparation channel; 150, chromatographic column; 160, detector; 170, display screen assembly; 180, housing assembly; 190, waste liquid channel; 101, liquid chromatography-mass spectrometry analyzer; 1010, chromatographic device; 1011, pretreatment device; 1011a, magnetic separation component; 1011b, magnetic bead elution component; 1011c, reagent storage component; 1011d, reagent distribution component; 1011e, pipetting component; 1011f, reaction container providing component; 1012, sample storage device; 200, blood cell analyzer; 300, sample transfer device; 310, first transfer track; 320, second transfer track; 400, sample input device; 500, control component; 600, information acquisition device; 20, first fluid container; 30, second fluid container; 40, hemolytic agent container. DETAILED DESCRIPTION

[0115] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0116] In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the fact that ordinary technicians in this field can implement them. When the combination of technical solutions is mutually contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0117] The solution provided in the embodiment of the present application can be applied to the scenario of continuous injection of liquid chromatography equipment (i.e., the sample is concentrated and continuously injected); it can also be applied to the scenario of intermittent injection of liquid chromatography equipment (i.e., the sample is not concentrated and continuously injected), so as to solve the problem of frequent pressure building and pressure relief of liquid chromatography equipment in intermittent injection scenario, resulting in loss of liquid phase fluid, low utilization efficiency, and the problem of slow detection speed and inability to be used online with other analyzers due to the long pressure building process. The liquid chromatography equipment performs elution detection on the sample by liquid chromatography. Liquid chromatography refers to the use of the different affinity such as distribution coefficient and adsorption capacity of various components in the sample in the liquid and solid phases to separate and elute. Due to the differences in properties and structures of the components, the size and strength of the forces generated between the components and the stationary phase are different. As the mobile phase moves, the mixture undergoes repeated distribution equilibrium between the two phases, so that the various components are retained by the stationary phase for different times, thereby flowing out from the stationary phase in a certain order.

[0118] The liquid chromatography device provided in the embodiment of the present application can be a glycated hemoglobin analyzer, or it can be other equipment that uses liquid chromatography, such as a device that combines liquid chromatography with mass spectrometry or a device that uses liquid chromatography to detect urine samples or other non-blood samples. The glycated hemoglobin analyzer provided in the embodiment of the present application uses liquid chromatography to detect glycated hemoglobin. Since in specific applications, there are not many samples that need to be analyzed for glycated hemoglobin, the glycated hemoglobin analyzer generally needs intermittent sampling. Applying the solution of the embodiment of the present application to the glycated hemoglobin analyzer is beneficial for the online use of the glycated hemoglobin analyzer with other analyzers, such as online as a cascade system or an assembly line.

[0119] Example 1:

[0120] As shown in Figures 1 to 11, a sample analysis system 10 provided in the first embodiment of the present application includes a sample input device 400, a first analyzer, a second analyzer, a sample transfer device 300, and a control assembly 500. The sample analysis system 10 is a sample analysis cascade system or a sample analysis pipeline for connecting at least two analyzers. The sample input device 400 is used to receive at least a sample container containing a sample to facilitate sample loading. The sample container is used to hold a sample collected from a patient. The first analyzer is used to draw a sample from the sample container and perform a first analysis on at least a portion of the drawn sample. The second analyzer is used to draw a sample from the sample container and perform a second analysis on at least a portion of the drawn sample. The sample transfer device 300 is used to transfer the sample container from the sample input device 400 to the first analyzer and / or the second analyzer. The control assembly 500 is used to control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer.

[0121] As an embodiment, the above-mentioned sample is a sample collected from a human body or an animal body, that is, the sample is a human sample or an animal sample.

[0122] In one embodiment, the sample is a blood sample, and the sample input device 400 is at least used to receive a sample container containing the blood sample to enable loading of the blood sample. Specifically, the sample analysis system 10 in this embodiment is a cascade system or pipeline for analyzing blood samples. Of course, in specific applications, the sample is not limited to a blood sample; for example, a urine sample or other body fluid sample may also be used.

[0123] In one embodiment, the first analyzer is a liquid chromatography device, i.e., the first analysis item is a chromatographic elution analysis item. The liquid chromatography device is used to aspirate a sample from a sample container and perform chromatographic elution and analysis on at least a portion of the aspirated sample. In this embodiment, the liquid chromatography device can be used in conjunction with other analyzers without affecting the detection efficiency of the other analyzers.

[0124] As an embodiment, the liquid chromatography device may be a liquid chromatography analyzer 100, or the liquid chromatography device may be a liquid chromatography-mass spectrometry analyzer 101. The liquid chromatography analyzer 100 uses an ultraviolet detector 160 or a fluorescence detector 160 as the detector 160; the liquid chromatography-mass spectrometry analyzer 101 uses a mass spectrometry detector 160 as the detector 160.

[0125] In one embodiment, the first analyzer is a liquid chromatograph 100, i.e., the first analysis item is a chromatographic analysis item. The liquid chromatograph 100 is configured to draw a sample from a sample container and perform a chromatographic analysis on at least a portion of the drawn sample. In this embodiment, the liquid chromatograph 100 can be used in conjunction with other analyzers without affecting the detection efficiency of the other analyzers.

[0126] As an embodiment, the liquid chromatograph 100 is used to draw a blood sample from a sample container and perform chromatographic analysis on at least a portion of the drawn blood sample. Of course, in specific applications, the liquid chromatograph 100 is not limited to performing chromatographic analysis on blood samples. For example, the liquid chromatograph 100 can also be used to perform chromatographic analysis on urine samples or other samples. That is, the liquid chromatograph 100 can be used to draw a urine sample or other sample from a sample container and perform chromatographic analysis on at least a portion of the drawn urine sample or other sample.

[0127] As an embodiment, the second analyzer is a flow analyzer, which uses an optical detection component to perform optical detection on the optical detection test liquid flowing through the flow chamber.

[0128] As an embodiment, the second analyzer is a cell analyzer, that is, the second analysis item mentioned above is a cell analysis item.

[0129] As an embodiment, the second analyzer is a blood cell analyzer 200, that is, the second analysis item mentioned above is a blood cell analysis item. The blood cell analyzer 200 is also called a routine blood analyzer or a hematology analyzer, and the blood cell analysis item is also called a routine blood analysis item. The blood cell analyzer 200 is used to draw a blood sample from a sample container and perform a blood cell analysis on at least a portion of the drawn blood sample. In specific applications, the demand for blood cell analysis is relatively large. Connecting the liquid chromatography analyzer 100 with the blood cell analyzer 200 is conducive to the chromatographic analysis item and the blood cell analysis item sharing the blood sample in the same sample container, so that the blood sample in one sample container can produce two test results, namely liquid chromatography analysis results and blood cell analysis results, thereby helping to reduce the amount of blood samples collected from patients and reduce the consumption of sample containers.

[0130] As an embodiment, the sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatograph analyzer 100, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the hematology analyzer 200. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected, that is, the first transfer track 310 and the second transfer track 320 can be the same transfer track or two transfer tracks spliced ​​together. The sample transfer device 300 allows the sample container of the sample input device 400 to be automatically transported to the liquid chromatograph analyzer 100 or automatically transferred to the hematology analyzer 200, without the need for manual sorting and transfer of sample containers between the liquid chromatograph analyzer 100 and the hematology analyzer 200, thereby reducing the workload of operators and improving the efficiency of batch sample testing.

[0131] As an embodiment, the sample suction position of the liquid chromatograph analyzer 100 can be inside the machine or on the first transfer track 310 outside the machine. When the sample suction position of the liquid chromatograph analyzer 100 is inside the machine, the liquid chromatograph analyzer 100 has a first sample suction channel inside. The sample container transferred to the side of the liquid chromatograph analyzer 100 by the first transfer track 310 can be dispatched to the sample suction position of the first sample suction channel through the first sample scheduling component.

[0132] As an embodiment, the sample aspiration position of the hematology analyzer 200 can be inside the machine or on the second transfer track 320 outside the machine. When the sample aspiration position of the hematology analyzer 200 is inside the machine, the hematology analyzer 200 has a second sample aspiration channel inside. The sample container transferred to the side of the hematology analyzer 200 by the second transfer track 320 can be dispatched to the sample aspiration position of the second sample aspiration channel through the second sample scheduling component.

[0133] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is configured to acquire information characterizing the type of test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of test item of the blood sample in the sample container based on the information characterizing the type of test item of the blood sample in the sample container fed back by the information acquisition device 600; and, based on the type of test item of the blood sample in the sample container, control the sample transfer device 300 to transfer the sample container to the liquid chromatograph analyzer 100 and / or the blood cell analyzer 200 for sample aspiration. The configuration of the information acquisition device 600 enables the control component 500 to automatically determine which analyzer to transfer the sample container to for analysis based on the information fed back by the information acquisition device 600.

[0134] As an embodiment, the liquid chromatograph analyzer 100 includes a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, and a detector 160. The sample supply assembly 110, the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150 are respectively connected to different interfaces of the reversing valve 130 through liquid circuits. The reversing valve 130 is mainly used to switch the flow direction of the liquid in the liquid circuit. The sample supply assembly 110 is used to draw a blood sample from a sample container and supply a test solution made from at least a portion of the drawn blood sample to the test solution preparation channel 140 through the reversing valve 130. The liquid-phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence. The chromatographic column 150 is used to adsorb the test solution and to provide a liquid phase fluid to elute the test solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150 .

[0135] In one embodiment, the reversing valve 130 has a switchable first and second communication states. In the first communication state, the reversing valve 130 connects the sample supply assembly 110 with the test solution preparation channel 140 and connects the liquid-phase fluid supply assembly 120 with the chromatographic column 150. In the second communication state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150, with the chromatographic column 150 connected between the reversing valve 130 and the detector 160. The reversing valve 130 can be switched between the first and second communication states under the control of the control assembly 500. In the first communication state, the sample supply assembly 110 can drive the test solution into the test solution preparation channel 140, and the liquid-phase fluid supply assembly 120 can drive the liquid-phase fluid into the chromatographic column 150. In the second communication state, the liquid-phase fluid supply assembly 120 can drive the liquid-phase fluid to transport the test solution in the test solution preparation channel 140 to the chromatographic column 150, while the sample supply assembly 110 cannot drive the test solution into the test solution preparation channel 140.

[0136] As an embodiment, the liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device 122. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 is used to store potential energy and release the stored potential energy. In this embodiment, by providing the energy storage device 122 in the liquid-phase fluid supply assembly 120, the liquid-phase fluid supply assembly 120 not only has the function of providing a liquid-phase fluid of a certain pressure, but also has the function of storing potential energy and releasing potential energy.

[0137] As an embodiment, the liquid-phase fluid supply assembly 120 further includes a locking and releasing device 123, which is used to lock and release the energy storage device 122. The locking and releasing device 123 can switch between a locked state and a released state. In a specific application, when the locking and releasing device 123 is in the released state, the energy storage device 122 can store potential energy under the pressure of the liquid-phase fluid; when the locking and releasing device 123 is in the locked state, the energy storage device 122 is locked and the potential energy stored in the energy storage device 122 cannot be released; when the locking and releasing device 123 switches from the locked state to the released state, the potential energy stored in the energy storage device 122 can be released. In this embodiment, an energy storage device 122 and a locking and releasing device 123 are provided in the liquid-phase fluid supply component 120, and the locking and releasing device 123 is provided to release the potential energy storage and release component 1222 of the energy storage device 122 in the released state to allow the energy storage device 122 to store and release potential energy under the pressure of the liquid-phase fluid, and the locking and releasing device 123 is provided to lock the potential energy storage and release component 1222 in the locked state to prevent the energy storage device 122 from releasing the stored potential energy, so that the liquid-phase fluid supply component 120 has the function of storing and releasing potential energy in addition to providing liquid-phase fluid of a certain pressure.

[0138] As an embodiment, the energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially disposed in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid phase fluid to flow through. The potential energy storage and release component 1222 is at least partially capable of moving relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy.

[0139] In one embodiment, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the housing 1221 and releasing the stored potential energy. In the released state, the potential energy storage and release component 1222 can move relative to the housing 1221 under the pressure of the liquid fluid to store potential energy. When the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the housing 1221 and release the stored potential energy. In this embodiment, the locking and releasing device 123 locks the potential energy storage and release component 1222 by directly applying a force to the potential energy storage and release component 1222.

[0140] As an embodiment, the control component 500 is further configured to: during the execution of a chromatographic analysis project of a sample (for ease of distinction, it can also be described as the current sample or the previous sample), control the first driving device 121 to drive the liquid phase fluid to flow to elute the test solution adsorbed on the chromatographic column 150, and control the energy storage device 122 to store potential energy through the pressure of the liquid phase fluid; after completing the chromatographic analysis project of a sample (the previous sample), and when executing the chromatographic analysis project of the next sample, control the energy storage device 122 to release the potential energy stored during the execution of the chromatographic analysis project of a sample (the previous sample) to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. This embodiment utilizes the potential energy stored in the energy storage device 122 to reduce energy loss and liquid fluid loss; and utilizes the potential energy released by the energy storage device 122 to assist in rapidly building pressure of the liquid fluid, thereby accelerating the speed of re-building pressure for the next sample. This avoids the problem of the next sample having to wait for a long time for pressure building before entering the liquid chromatograph analyzer 100 for analysis. As a result, each chromatographic analysis project can quickly generate a test report. Furthermore, when the liquid chromatograph analyzer 100 is used online with other analyzers, the transmission track will not be blocked due to the long queueing of samples of the liquid chromatograph analyzer 100, which will affect the sample transmission of other analyzers. This fully ensures the detection efficiency of samples in the online state.

[0141] As an embodiment, the above-mentioned control of the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid includes: controlling the lock-release device 123 to be in a released state to allow the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid. The above-mentioned control of the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample after completing the chromatographic analysis project of a sample and when executing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of a sample, controlling the lock-release device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow; after the lock-release device 123 switches to the locked state, when executing the chromatographic analysis project of the next sample, controlling the lock-release device 123 to switch from the locked state to the released state to allow the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample. In this embodiment, after completing the chromatographic analysis project of a sample, the locking device 123 is switched from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, thereby achieving the effect of storing energy and maintaining pressure. When executing the chromatographic analysis project of the next sample, the energy stored in the previous sample can be used to assist the liquid phase fluid in quickly building up pressure; of course, in specific applications, as an alternative implementation scheme, when two adjacent samples are continuously injected or the injection interval is very small (for example, less than the first preset time length described below), the pressure can also be maintained by controlling the first driving device 121 to keep driving the liquid phase fluid to flow, without the need for the locking device 123 to switch from the released state to the locked state, but this may result in a large consumption of the liquid phase fluid.

[0142] As an embodiment, the control component 500 is further configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column 150, control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the shell 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after the completion of the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, then control the locking and releasing device 123 to be released from the state. The state is switched to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the shell 1221, thereby preventing the potential energy storage and release component 1222 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 is switched to the locked state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the shell 1221 and release the stored potential energy to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. In this embodiment, the potential energy stored in the energy storage device 122 is used to reduce energy loss in the intermittent injection scenario; the potential energy released by the energy storage device 122 is used to assist in the rapid pressure buildup of the liquid phase fluid, thereby accelerating the speed of re-building pressure in the intermittent injection scenario, thereby avoiding the problem that the intermittently injected blood samples need to wait for a long time to build pressure before entering the liquid chromatograph analyzer 100 for analysis, so that each chromatographic analysis project can quickly produce a test report, and when the liquid chromatograph analyzer 100 is used online with other analyzers, the blood samples of the liquid chromatograph analyzer 100 are not queued for a long time, resulting in the blockage of the transmission track and affecting the sample transmission of other analyzers, thereby fully ensuring the detection efficiency of the samples in the online state. In addition, when the lock and release device 123 locks the potential energy storage and release component 1222, since the first drive device 121 for driving the flow of the liquid phase fluid in the liquid phase fluid supply component 120 is in a stopped state, the first drive device 121 is prevented from continuing to operate when there is no blood sample to perform the chromatographic analysis project test, resulting in the waste of liquid phase fluid.

[0143] As an embodiment, the control component 500 is further configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column 150, control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the shell 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after the completion of the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, then control the locking and releasing device 123 to be released from the state. The state is switched to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the shell 1221, thereby preventing the potential energy storage and release component 1222 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 is switched to the locked state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the shell 1221 and release the stored potential energy to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. In this embodiment, the potential energy stored in the energy storage device 122 is used to reduce energy loss in the intermittent injection scenario; the potential energy released by the energy storage device 122 is used to assist in the rapid pressure buildup of the liquid phase fluid, thereby accelerating the speed of re-building pressure in the intermittent injection scenario, thereby avoiding the problem that the intermittently injected blood samples need to wait for a long time to build pressure before entering the liquid chromatograph analyzer 100 for analysis, so that each chromatographic analysis project can quickly produce a test report, and when the liquid chromatograph analyzer 100 is used online with other analyzers, the blood samples of the liquid chromatograph analyzer 100 are not queued for a long time, resulting in the blockage of the transmission track and affecting the sample transmission of other analyzers, thereby fully ensuring the detection efficiency of the samples in the online state. In addition, when the lock and release device 123 locks the potential energy storage and release component 1222, since the first drive device 121 for driving the flow of the liquid phase fluid in the liquid phase fluid supply component 120 is in a stopped state, the first drive device 121 is prevented from continuing to operate when there is no blood sample to perform the chromatographic analysis project test, resulting in the waste of liquid phase fluid.

[0144] In one embodiment, the potential energy stored and released by the potential energy storage and release assembly 1222 is elastic potential energy. Specifically, the assembly converts part of the pressure energy of the liquid fluid into elastic potential energy by driving the deformation of an elastic component, storing it and releasing it when needed. This simple structure and low cost are key features. By storing and releasing elastic potential energy, the assembly can also eliminate pressure or flow pulsations in the liquid fluid within the pipeline. Of course, in specific applications, the configuration of the potential energy storage and release component 1222 is not limited to this. For example, as an alternative embodiment, the potential energy stored and released by the potential energy storage and release component 1222 is gravitational potential energy, and it converts the pressure energy of the liquid fluid into gravitational potential energy and accumulates it by lifting the mass block loaded on the sealing piston; or, as another alternative embodiment, the potential energy stored and released by the potential energy storage and release component 1222 is gas internal energy, and energy conversion is completed by compressing the gas. When in use, gas with a predetermined pressure is first filled into the energy storage device 122. When the pressure of the liquid fluid exceeds the pressure inside the energy storage device 122, the liquid fluid compresses the gas and converts the pressure of the liquid fluid into gas internal energy; when the pressure of the liquid fluid is lower than the pressure inside the energy storage device 122, the liquid fluid in the energy storage device 122 flows out of the energy storage device 122 under the action of the high-pressure gas to release energy.

[0145] As an embodiment, the locking and releasing device 123 applies a force to the potential energy storage and release assembly 1222 to lock the potential energy storage and release assembly 1222 in a non-liquid path locking manner, and the locking and releasing device 123 removes the force applied to the potential energy storage and release assembly 1222 in a non-liquid path conduction manner to release the potential energy storage and release assembly 1222. In this embodiment, the locking and releasing device 123 is not connected to the energy storage device 122 via a liquid path, but rather locks and releases the potential energy storage and release assembly 1222 of the energy storage device 122 through a mechanical structure. In this way, the provision of the locking and releasing device 123 does not affect the original liquid path system of the liquid chromatograph analyzer 100.

[0146] As an embodiment, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 by abutting against the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 by separating from the potential energy storage and release component 1222 to release the potential energy storage and release component 1222. In this embodiment, the locking and releasing device 123 locks and limits the potential energy storage and release component 1222 by directly contacting the potential energy storage and release component 1222, and releases the limit on the potential energy storage and release component 1222 by separating from the potential energy storage and release component 1222. Of course, in specific applications, as an alternative embodiment, the locking and releasing device 123 can also apply a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222 by non-contacting the potential energy storage and release component 1222, for example, by magnetic attraction.

[0147] As an embodiment, the potential energy storage and release assembly 1222 has a latching portion 1222d extending outside the housing 1221. The locking and releasing device 123 applies a force to the potential energy storage and release assembly 1222 by limiting the latching portion 1222d, thereby locking the potential energy storage and release assembly 1222. The locking and releasing device 123 removes the force applied to the potential energy storage and release assembly 1222 by releasing the latching portion 1222d, thereby releasing the potential energy storage and release assembly 1222. In this embodiment, the locking and releasing device 123 locks the potential energy storage and release assembly 1222 by limiting the latching portion 1222d extending outside the housing 1221, eliminating the need to machine a structure that cooperates with the locking and releasing device 123 on the housing 1221, thereby simplifying the structure of the energy storage device 122. Of course, in a specific application, as an alternative implementation scheme, the locking and releasing device 123 can also be set to be inserted into the shell 1221 to lock and limit the potential energy storage and release component 1222.

[0148] In one embodiment, the locking and releasing device 123 includes a power component 1231, a locking component 1232, and a transmission component 1233 that is transmission-connected between the power component 1231 and the locking component 1232. The power component 1231 is used to drive the transmission component 1233, which in turn drives the locking component 1232, thereby moving the locking component 1232 between a locked position and an unlocked position. In the locked position, the locking component 1232 abuts the potential energy storage and release assembly 1222 to lock the potential energy storage and release assembly 1222. In the unlocked position, the locking component 1232 disengages from the potential energy storage and release assembly 1222 to release the potential energy storage and release assembly 1222.

[0149] As an embodiment, when the locking and releasing device 123 is in a locked state, the locking component 1232 is in a locked position to lock the potential energy storage and release assembly 1222 .

[0150] As an embodiment, the transmission component 1233 has a self-locking capability. When the lock-release device 123 is in the locked state, the power component 1231 is in a stopped state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233, thereby locking the potential energy storage and release assembly 1222. In this embodiment, the self-locking of the transmission component 1233 allows the locking component 1232 to maintain the state of locking the potential energy storage and release assembly 1222, without the need for the power component 1231 to provide power locking. The power component 1231 is only used to drive the transmission component 1233 to drive the locking component 1232 between the locked position and the unlocked position, thereby reducing the load requirement of the power component 1231 and thus helping to reduce the cost of the lock-release device 123.

[0151] As an embodiment, the power component 1231 is a motor; when the locking and releasing device 123 is in a locked state, the motor is in a stopped state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233 to lock the potential energy storage and release component 1222; when the locking and releasing device 123 is in a released state, the motor is in a stopped state, and the locking component 1232 is in an unlocked position to release the potential energy storage and release component 1222; in the process of the locking and releasing device 123 switching from the locked state to the released state, the motor is in a running state to drive the locking component 1232 to move from the locked position to the unlocked position through the transmission component 1233; in the process of the locking and releasing device 123 switching from the released state to the locked state, the motor is in a running state to drive the locking component 1232 to move from the unlocked position to the locked position through the transmission component 1233.

[0152] As an embodiment, the potential energy storage and release component 1222 has a locking portion 1222d extending outside the shell 1221, and the locking portion 1222d has a locking end face facing the liquid chamber 1223; the locking component 1232 is formed with a locking portion 1232a, and the locking portion 1232a is used to move between a locked position and an unlocked position under the drive of the power component 1231 and the transmission component 1233.

[0153] As an embodiment, the above-mentioned control of the locking and releasing device 123 to switch to a locked state to prevent the energy storage device 122 from releasing the stored potential energy includes: controlling the power component 1231 to start and run to drive the transmission component 1233 to drive the locking portion 1232a to move from the unlocked position to the locked position, so that the locking portion 1232a abuts against the locking end face; after the locking portion 1232a moves to the locked position, controlling the power component 1231 to stop running so that the locking portion 1232a remains in the locked position under the action of the locking force generated by the self-locking of the transmission component 1233.

[0154] As an embodiment, the above-mentioned control of the locking and releasing device 123 switches from a locked state to a released state, so that the energy storage device 122 releases the stored potential energy, including: controlling the power component 1231 to start and run, so as to drive the transmission component 1233 to drive the locking portion 1232a to move from the locked position to the unlocked position, so that the locking portion 1232a disengages from the locking end face, thereby causing the potential energy storage and release component 1222 to release the stored potential energy and move toward the liquid cavity 1223, so as to drive the liquid phase fluid in the liquid cavity 1223 to flow out of the liquid cavity 1223.

[0155] As an embodiment, the locking and releasing device 123 also includes a detection component 1234, and the control component 500 is further configured to: obtain feedback information from the detection component 1234 during the process of the power component 1231 driving the transmission component 1233 to drive the locking part 1232a to move from the unlocking position to the locking position; when it is determined based on the feedback information of the detection component 1234 that the locking part 1232a has moved to the locking position, the power component 1231 is controlled to stop running.

[0156] As an embodiment, the detection component 1234 is a reflective photoelectric sensor, a through-beam photoelectric sensor, or a proximity switch.

[0157] As an embodiment, the potential energy stored and released by the potential energy storage and release component 1222 is elastic potential energy; the potential energy storage and release component 1222 includes a diaphragm 1222a, an elastic element 1222b and a guide rod 1222c, the diaphragm 1222a is arranged in the shell 1221, and cooperates with the inner wall of the shell 1221 to form a liquid cavity 1223, one end of the guide rod 1222c is connected to the diaphragm 1222a, and the other end of the guide rod 1222c extends to the outside of the shell 1221 and forms a locking portion 1222d, and the elastic element 1222b is located in the shell 1221 and is sleeved on the guide rod 1222c. When the locking device 123 is in a locked state, it includes: the locking portion 1232a abuts the locking portion 1222d to lock the locking portion 1222d, thereby allowing the elastic element 1222b to store elastic potential energy; when the locking device 123 is in a released state, it includes: the locking portion 1232a disengages from the locking portion 1222d to release the locking portion 1222d, thereby allowing the elastic element 1222b to release the elastic potential energy.

[0158] As an embodiment, when the locking and releasing device 123 is in a released state, the guide rod 1222c can overcome the force of the elastic element 1222b under the action of the pressure of the liquid phase fluid and move in the direction away from the liquid cavity 1223, and can move in the direction close to the liquid cavity 1223 under the action of the elastic element 1222b; when the locking and releasing device 123 is in a locked state, the guide rod 1222c can overcome the force of the elastic element 1222b under the action of the pressure of the liquid phase fluid and move in the direction away from the liquid cavity 1223, but cannot move in the direction close to the liquid cavity 1223 under the action of the elastic element 1222b.

[0159] As an implementation manner, the first driving device 121 may be a plunger pump.

[0160] As an implementation manner, the energy storage device 122 can smooth the pulse flow output by the first driving device 121 through the elastic element 1222b, thereby reducing flow fluctuation.

[0161] As an embodiment, the diaphragm 1222a is a diaphragm made of elastic material, the periphery of which is sealed and fixed, and a rod is embedded in the center, and the rod is connected to or integrally formed with the guide rod 1222c.

[0162] As an embodiment, the stiffness of the elastic element 1222b is greater than or equal to 500 N / mm and less than or equal to 30,000 N / mm.

[0163] As an embodiment, the elastic element 1222b includes at least one pair of disc spring groups. The disc springs have high elasticity and can meet the requirement of providing a large driving force for the liquid phase fluid.

[0164] As an embodiment, the transmission component 1233 includes a screw transmission pair, and the thread lead angle of the screw transmission pair is smaller than the equivalent friction angle.

[0165] In one embodiment, transmission component 1233 includes a lead screw transmission pair, which is a trapezoidal lead screw transmission pair. In this embodiment, the motor torque only needs to be sufficient to drive the locking component 1232 to move under no-load conditions, and does not need to overcome the force of the elastic element 1222b. Therefore, in this embodiment, the motor output torque can be set to be much smaller than the torque required to pull the deformed elastic element 1222b.

[0166] As an embodiment, the screw drive pair includes a screw and a nut, the nut is connected to the screw, and the nut is connected to the guide shaft, the function of the guide shaft is to convert the rotational motion of the nut into linear motion. The locking component 1232 is connected to the nut of the screw pair. The screw drive pair of this embodiment is a trapezoidal screw drive pair with a self-locking function, which meets the self-locking condition that the thread lead angle is less than the equivalent friction angle. The output shaft of the motor is fixedly connected to the screw to provide power for the rotation of the screw.

[0167] As an embodiment, the detection component 1234 is an optical coupler fixed on the base. The locking component 1232 is connected to an optical coupler block.

[0168] As an embodiment, the working principle of the energy storage device 122 and the locking and releasing device 123 is as follows: when high-pressure liquid fluid flows into the energy storage device 122, the diaphragm 1222a deforms toward the side where the elastic element 1222b is located under the pressure of the liquid fluid. The load is transmitted to the elastic element 1222b by the guide rod 1222c, converting the pressure potential energy of the liquid fluid into the elastic potential energy of the elastic element 1222b. At the same time, the guide rod 1222c moves in a direction away from the liquid cavity 1223. In this embodiment, the locking portion 1232a pulls the locking portion 1222d of the extended guide rod 1222c, preventing it from rebounding under the action of the elastic element 1222b, thereby allowing the elastic element 1222b to retain its elastic potential energy. When the locking and releasing device 123 is in the initial position, the diaphragm 1222a of the energy storage device 122 is not deformed, and the elastic element 1222b in the energy storage device 122 is in the initial state (with pre-pressure or without force). When the energy storage device 122 is operating, the diaphragm 1222a deforms away from the liquid chamber 1223, causing the guide rod 1222c to move toward the elastic element 1222b. This displacement fluctuates within a small range as the pulsed flow of the liquid phase fluid is input. When the energy storage device 122 stops operating, the pressure slowly decreases due to system damping. At this point, the guide rod 1222c gradually moves toward the liquid chamber 1223 under the action of the elastic element 1222b. At this point, the motor of the locking and releasing device 123 rotates, driving the locking component 1232 away from the liquid chamber 1223 until the locking portion 1232a contacts the retaining portion 1222d of the guide rod 1222c. At this point, the motor drives locking member 1232 to move a certain distance away from liquid chamber 1223 and then stops. This distance is greater than the maximum rightward movement distance of guide rod 1222c. Because the motor's torque is insufficient to overcome the force of elastic element 1222b, it does not pull guide rod 1222c excessively to the right, potentially causing the motor to stall briefly. Due to the self-locking effect of the screw drive pair, guide rod 1222c does not continue to move leftward under the action of elastic element 1222b, but instead remains in this state. At this point, the liquid in liquid chamber 1223, without the effect of additional load, only flows out in small amounts, thereby reducing liquid phase fluid consumption. The next time pressure is built up, only a small amount of liquid phase fluid is needed to fill liquid chamber 1223, reducing pressure buildup time. Simultaneously, after the hydraulic system completes pressure buildup, pressure causes guide rod 1222c to move rightward again and disengage from locking member 1232. The motor then drives locking member 1232 back to its initial position, allowing it to lock guide rod 1222c again.

[0169] As an embodiment, if information is obtained that a chromatographic analysis project needs to be performed on a blood sample, the locking and releasing device 123 is controlled to switch from a locked state to a released state, including: if information is obtained that a chromatographic analysis project needs to be performed on a blood sample, the first driving device 121 is first controlled to start and run, and then the locking and releasing device 123 is controlled to switch from a locked state to a released state. In this embodiment, before the locking and releasing device 123 is switched from the locked state to the released state, the first driving device 121 is first controlled to start and run so that the liquid phase fluid has a certain pressure, thereby avoiding the undesirable phenomenon that the potential energy is completely released when the locking and releasing device 123 switches from the locked state to the released state, resulting in the need for a larger pressure to re-drive the potential energy storage and release component 1222 to expand.

[0170] As an embodiment, the control component 500 is further configured to: during the execution of a chromatographic analysis project, control the first drive device 121 to drive the liquid-phase fluid to flow at a target pressure value or a pressure value within a target pressure range to elute the test solution adsorbed on the chromatographic column 150; and before executing the first chromatographic analysis project after the liquid chromatograph 100 is powered on, first control the first drive device 121 to start and maintain operation for a third preset time period so that the pressure of the liquid-phase fluid flowing to the chromatographic column 150 reaches the target pressure value or the target pressure range. The third preset time period is the pressure buildup time before the execution of the first chromatographic analysis project after the liquid chromatograph 100 is powered on, that is, the time it takes for the pressure of the liquid-phase fluid in the liquid circuit system to increase from zero to the target pressure value or the target pressure range.

[0171] As an embodiment, the target pressure value is greater than or equal to 2 MPa and less than or equal to 10 MPa.

[0172] As an embodiment, the target pressure value is greater than or equal to 4 MPa and less than or equal to 6 MPa.

[0173] As an embodiment, the above-mentioned control of the first driving device 121 to start and run, and then controlling the lock-release device 123 to switch from the locked state to the released state includes: first controlling the first driving device 121 to start and keep running for a second preset time, so that the pressure of the liquid-phase fluid flowing to the chromatographic column 150 is greater than zero and less than the target pressure value or less than the lower limit of the target pressure range, and then controlling the lock-release device 123 to switch from the locked state to the released state. The control component 500 is also configured to: after controlling the lock-release device 123 to switch from the locked state to the released state, first control the first driving device 121 to continue to run for a fourth preset time, so that the pressure of the liquid-phase fluid flowing to the chromatographic column 150 approximately reaches the target pressure value or the target pressure range, and then control the reversing valve 130 to switch to the second connected state, so that the liquid-phase fluid supply component 120 drives the test solution in the test solution preparation channel 140 to be delivered to the chromatographic column 150 through the liquid-phase fluid; wherein the sum of the second preset time and the fourth preset time is less than the third preset time. The sum of the second preset time and the fourth preset time is the pressure buildup time during the intermittent sampling process. In this embodiment, the potential energy stored in the energy storage device 122 assists the pressure buildup drive during the intermittent sampling process, thereby shortening the pressure buildup time during the intermittent sampling process.

[0174] Preferably, the sum of the second preset time length and the fourth preset time length is less than half of the third preset time length.

[0175] Preferably, the sum of the second preset time length and the fourth preset time length is less than or equal to one tenth of the third preset time length.

[0176] As an embodiment, the housing 1221 is formed with a liquid inlet 1221a for supplying liquid-phase fluid into the liquid chamber 1223 and a liquid outlet 1221b for supplying liquid-phase fluid out of the liquid chamber 1223; after the control lock-release device 123 is switched to the locked state and the first driving device 121 is controlled to stop driving the liquid-phase fluid flow, and before the control first driving device 121 is started and the control lock-release device 123 is switched from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a first pressure value; after the first driving device 121 is started and maintained in operation for a second preset time period, and during the process of the lock-release device 123 switching from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a second pressure value; after the lock-release device 123 is switched from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a third pressure value. Wherein, the second pressure value is greater than the first pressure value and greater than the third pressure value. In this embodiment, during the process of intermittent injection and re-building pressure, the pressure of the liquid phase fluid first increases and then decreases under the auxiliary driving force of the potential energy released by the energy storage device 122, thereby facilitating the purpose of rapid pressure building.

[0177] As an embodiment, the first pressure value is less than the target pressure value or less than the lower limit of the target pressure range; the second pressure value is greater than the target pressure value or greater than the upper limit of the target pressure range; the third pressure value is approximately equal to the target pressure value or falls within the target pressure range.

[0178] As an embodiment, after the control lock-release device 123 switches to the locked state and the first drive device 121 stops driving the flow of the liquid phase fluid, and before the control first drive device 121 starts and the control lock-release device 123 switches from the locked state to the released state, the volume of the liquid chamber 1223 is the first volume; after the first drive device 121 starts and keeps running for a second preset time, and before the lock-release device 123 switches from the locked state to the released state, the volume of the liquid chamber 1223 is the second volume; after the lock-release device 123 switches from the locked state to the released state, the volume of the liquid chamber 1223 is the third volume; wherein, the second volume is greater than the first volume and greater than the third volume. In this embodiment, in the process of intermittent sampling and re-building pressure, the volume of the liquid chamber 1223 first increases and then decreases, which is conducive to achieving the purpose of rapid pressure building.

[0179] As an embodiment, the first volume is less than or approximately equal to the volume of the liquid cavity 1223 during the execution of the chromatographic analysis project, the second volume is greater than the volume of the liquid cavity 1223 during the execution of the chromatographic analysis project, and the third volume is approximately equal to the volume of the liquid cavity 1223 during the execution of the chromatographic analysis project.

[0180] As an embodiment, after controlling the locking and releasing device 123 to switch to the locked state and controlling the first driving device 121 to stop driving the flow of the liquid phase fluid, and before controlling the first driving device 121 to start running and controlling the locking and releasing device 123 to switch from the locked state to the released state, the potential energy stored in the energy storage device 122 is the first potential energy; after controlling the first driving device 121 to start and keep running for a second preset time, and before controlling the locking and releasing device 123 to switch from the locked state to the released state, the potential energy stored in the energy storage device 122 is the second potential energy; after the locking and releasing device 123 switches from the locked state to the released state, the potential energy stored in the energy storage device 122 is the third potential energy; wherein, the second potential energy is greater than the first potential energy and greater than the third potential energy.

[0181] As an embodiment, the first potential energy is less than or approximately equal to the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis project, the first potential energy is greater than the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis project, and the third potential energy is approximately equal to the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis project.

[0182] As an embodiment, the energy storage device 122 has a liquid inlet 1221a for supplying liquid-phase fluid to flow in and a liquid outlet 1221b for supplying liquid-phase fluid to flow out; after the control lock-release device 123 is switched to the locked state and the first drive device 121 is controlled to stop driving the flow of the liquid-phase fluid, and before the control first drive device 121 is started and the control lock-release device 123 is switched from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a first pressure value; the first pressure value is approximately zero. In this embodiment, when the first drive device 121 stops driving the flow of the liquid-phase fluid and the energy storage device 122 is in the locked state, the pressure value of the liquid-phase fluid is approximately zero, which helps to reduce the loss of the liquid circuit device components caused by maintaining high pressure in the liquid circuit for a long time.

[0183] As an embodiment, within the first preset time period after the completion of a chromatographic analysis project of a blood sample, if no other blood samples are obtained that need to be subjected to the chromatographic analysis project, the locking device 123 is controlled to switch to a locked state, and the first driving device 121 is controlled to stop driving the liquid-phase fluid to flow, including: within the first preset time period after the completion of a chromatographic analysis project of a blood sample, if no information is obtained that other blood samples need to be subjected to the chromatographic analysis project, the locking device 123 is first controlled to switch to a locked state, and then the first driving device 121 is controlled to stop driving the liquid-phase fluid to flow. In this embodiment, when it is necessary to lock the energy storage device 122 to lock potential energy, the locking device 123 is first controlled to switch to a locked state, and then the first driving device 121 is controlled to stop running. In this way, when the locking device 123 switches to a locked state, the pressure of the liquid-phase fluid prevents the energy storage device 122 from releasing potential energy, thereby better locking the potential energy of the energy storage device 122. Of course, in specific applications, the control sequence of the locking and releasing device 123 and the first driving device 121 is not limited to this. For example, as an alternative implementation scheme, within the first preset time after the completion of the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, the locking and releasing device 123 is controlled to switch to a locked state, and the first driving device 121 is controlled to stop driving the liquid-phase fluid flow; or, as another alternative implementation scheme, within the first preset time after the completion of the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, the first driving device 121 is first controlled to stop driving the liquid-phase fluid flow, and then the locking and releasing device 123 is controlled to switch to a locked state.

[0184] As an embodiment, the control component 500 is further configured to: control the sample supply component 110 to perform the following test solution preparation actions within a fifth preset time: draw the blood sample from the sample container and distribute it to the first reaction container 112, and transport the test solution made of at least the blood sample and the hemolytic agent in the first reaction container 112 to the sample preparation channel through the reversing valve 130; when the lock and release device 123 is in a locked state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, control the liquid phase fluid supply component 120 to perform the following test solution preparation actions within a sixth ... The following pressure-building action: control the first driving device 121 to start and run, control the lock-release device 123 to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply component 120 driving the liquid-phase fluid to flow to the chromatographic column 150 reaches the target pressure value or the target pressure range within the sixth preset time; in the process of executing the chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow at the target pressure value or the pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column 150; wherein the sixth preset time is less than the fifth preset time. The sixth preset time is equal to the sum of the second preset time and the fourth preset time. In this embodiment, in the intermittent scenario, the time for re-building pressure is less than the time for preparing the test solution, which is conducive to making the re-building pressure and the preparation of the test solution can be carried out simultaneously.

[0185] As an embodiment, the control component 500 is also configured to: when the locking and releasing device 123 is in a locked state and the reversing valve 130 is in a first connected state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, the sample supply component 110 is controlled to perform the following test solution preparation action: the blood sample is drawn from the sample container and distributed to the first reaction container 112, and the test solution made of at least the blood sample and the hemolytic agent in the first reaction container 112 is transported to the sample preparation channel through the reversing valve 130; in the process of the sample supply component 110 performing the test solution preparation action, the first driving device 121 is controlled to start and run, the locking and releasing device 123 is controlled to switch from the locked state to the released state, and the reversing valve 130 is controlled to remain in the first connected state; after the sample supply component 110 completes the test solution preparation action, the reversing valve 130 is controlled to switch from the first connected state to the second connected state, so that the liquid-phase fluid supply component 120 drives the test solution in the test solution preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid. In this embodiment, when a blood sample that needs to be subjected to a chromatographic analysis project is transferred to the liquid chromatograph analyzer 100, the test solution preparation action can be performed directly without waiting, thereby achieving the effect of immediate testing of the blood sample at the liquid chromatograph analyzer 100, and effectively avoiding the undesirable phenomenon of sample containers queuing on the transfer track causing blockage of the transfer track.

[0186] As an embodiment, the control component 500 is further configured to: when the lock-release device 123 is continuously locked for a seventh preset time period, if no information is obtained that a blood sample requires a chromatographic analysis project, control the lock-release device 123 to switch from the locked state to the released state, so that the energy storage device 122 releases stored potential energy; the seventh preset time period is greater than the time required to complete a chromatographic analysis project and greater than the first preset time period. This embodiment, by limiting the length of time that the lock-release device 123 continuously locks the energy storage device 122, helps avoid the undesirable phenomenon of the potential energy storage and release component 1222 being subjected to long-term deformation, which affects its lifespan.

[0187] As an embodiment, the seventh preset time period is greater than or equal to the time period required to complete 10 chromatographic analysis projects.

[0188] As an implementation manner, the seventh preset duration is greater than or equal to 5 minutes and less than or equal to 2 hours.

[0189] As an embodiment, the liquid chromatograph analyzer 100 also includes a waste liquid channel 190. In a first connection state, the reversing valve 130 connects the sample supply component 110, the test liquid preparation channel 140 and the waste liquid channel 190, and connects the liquid-phase fluid supply component 120 and the chromatographic column 150. In a second connection state, the reversing valve 130 connects the liquid-phase fluid supply component 120, the test liquid preparation channel 140 and the chromatographic column 150, and connects the sample supply component 110 and the waste liquid channel 190.

[0190] As an embodiment, the liquid-phase fluid supply assembly 120 further includes a third drive device 124. The first drive device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The first drive device 121 draws a first fluid from the first fluid container 20 and delivers it to the reversing valve 130 and the chromatographic column 150. The third drive device 124 draws a second fluid from the second fluid container 30 and delivers it to the reversing valve 130 and the chromatographic column 150. During the process of the liquid-phase fluid supply assembly 120 driving the test fluid in the test fluid preparation channel 140 to be delivered to the chromatographic column 150, the first drive device 121 is controlled to be in an operating state, and the third drive device 124 is controlled to be in a stopped state. The control assembly 500 is further configured to control the operation of the first driving device 121 and the second driving device 126 during elution of a test solution, and to adjust the operating parameters of the first driving device 121 and the second driving device 126 so that the liquid-phase fluid supply assembly 120 supplies at least two liquid-phase fluids containing a second fluid of different concentrations to the chromatographic column 150 at different time periods; wherein the ionic strength of the second fluid is greater than the ionic strength of the first fluid. This embodiment allows for the online configuration of liquid-phase fluids of different concentrations and achieves a gradient elution effect.

[0191] As an embodiment, the liquid-phase fluid supply assembly 120 further includes a housing assembly 180 and a mixing element 125. The mixing element 125 has a first input port, a second input port, and an output port. The energy storage device 122 is connected between the first input port and the first drive element 121 via a fluid path. The third drive element 124 is connected to the second input port. The reversing valve 130 is connected to the output port. The housing assembly 180 is formed with a first fluid reservoir and a second fluid reservoir. The first fluid reservoir is used to accommodate the first fluid container 20, and the second fluid reservoir is used to accommodate the second fluid container 30. The first drive element 121 is used to draw the first fluid from the first fluid container 20 and push it to the reversing valve 130. The third drive element 124 is used to draw the second fluid from the second fluid container 30 and push it to the reversing valve 130. In this embodiment, by adjusting the mixing ratio of the first and second fluids, eluents containing different concentrations of the second fluid can be produced. This enables the online preparation of eluents of varying concentrations, meets the requirements of different eluent concentrations, and helps reduce material volume and material costs.

[0192] As an embodiment, the first fluid may be liquid A, and the second fluid may be liquid B.

[0193] Of course, in specific applications, the liquid-phase fluid supply assembly 120 is not limited to employing the aforementioned gradient elution scheme. For example, as an alternative embodiment, the liquid-phase fluid supply assembly 120 may also employ an isocratic elution scheme. In this alternative embodiment, the liquid-phase fluid supply assembly 120 further includes a switching member, wherein the input end of the first driving device 121 is switchably connected to a third fluid container containing a third fluid and a fourth fluid container containing a fourth fluid via the switching member. The first driving device 121 is configured to drive the liquid-phase fluid toward the reversing valve 130 and the chromatographic column 150, including: when the switching member connects the first driving device 121 to the third fluid container, the first driving device 121 draws the third fluid from the third fluid container and discharges it to the reversing valve 130 and the chromatographic column 150; when the switching member connects the first driving device 121 to the fourth fluid container, the first driving device 121 draws the fourth fluid from the fourth fluid container and discharges it to the reversing valve 130 and the chromatographic column 150. The third fluid and the fourth fluid are two liquid-phase fluids containing different concentrations of the second fluid. During the process of the liquid-phase fluid supply assembly 120 driving the test solution in the test solution preparation channel 140 to be delivered to the chromatographic column 150, the switching member connects the state of the first driving device 121 and the third fluid container, and controls the first driving device 121 to be in an activated and running state. The control assembly 500 is further configured to: during the process of eluting a test solution, in the first elution phase, control the switching member to connect the state of the first driving device 121 and the third fluid container, and control the first driving device 121 to draw the third fluid from the third fluid container and discharge it to the reversing valve 130 and the chromatographic column 150; in the second elution phase, control the switching member to connect the state of the first driving device 121 and the fourth fluid container, and control the first driving device 121 to draw the fourth fluid from the fourth fluid container and discharge it to the reversing valve 130 and the chromatographic column 150, so that the liquid-phase fluid supply assembly 120 supplies at least two liquid-phase fluids containing different concentrations of the second fluid to the chromatographic column 150 at different time periods.

[0194] As an embodiment, the sample supply assembly 110 includes a sampling component 111, a first reaction container 112, and a sample infusion liquid circuit 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion liquid circuit 113 is used to draw the hemolytic agent from the hemolytic agent container 40 and distribute it to the first reaction container 112, and is used to transport the test solution made of at least the sample and the hemolytic agent in the first reaction container 112 to the test solution preparation channel 140 through the reversing valve 130. The sample infusion liquid circuit 113 is provided with a suction and discharge power component 1231. In this embodiment, the hemolytic agent is distributed to the first reaction container 112 by the sample infusion liquid circuit 113, so that the sample infusion liquid circuit 113 can be reused, and there is no need to set up an additional pipette needle to distribute the hemolytic agent. The hemolytic agent mainly dissolves the red blood cells to release hemoglobin in the red blood cells in the sample, so that the whole blood sample can be processed into a test solution. Of course, in specific applications, the hemolytic agent can also be replaced with deionized water, purified water, or distilled water, which swells and ruptures the red blood cells in the sample through osmotic pressure. Deionized water, purified water, or distilled water primarily swells and ruptures the red blood cells in the whole blood sample through osmotic pressure, causing the red blood cells in the sample to release hemoglobin, thereby processing the whole blood sample into a test solution.

[0195] As an embodiment, the sampling component 111 includes a sample needle and a motion driving component for driving the sample needle to move.

[0196] As an embodiment, the liquid chromatograph analyzer 100 further includes a display screen assembly 170 . The display screen assembly 170 is disposed on one side of the housing assembly 180 for allowing an operator to view chromatographic analysis information of a blood sample.

[0197] As an embodiment, the working process of the liquid chromatograph analyzer 100 includes: the sample supply component 110 draws the sample from the sample container and distributes it to the first reaction container 112, distributes the hemolytic agent to the first reaction container 112, the sample supply component 110 pushes the test solution made of the sample and the hemolytic agent in the first reaction container 112 to the test solution preparation channel 140, the liquid-phase fluid supply component 120 drives the test solution in the test solution preparation channel 140 to the chromatographic column 150 through the liquid-phase fluid, the liquid-phase fluid supply component 120 pushes the liquid-phase fluid to the chromatographic column 150 to elute the test solution adsorbed on the chromatographic column 150, and the detector 160 performs chromatographic analysis on the test solution eluted from the chromatographic column 150.

[0198] As an embodiment, the liquid chromatography analyzer 100 is a glycated hemoglobin analyzer.

[0199] As an embodiment, the blood cell analyzer 200 is at least used to perform white blood cell differential counting on a blood sample.

[0200] As an embodiment, the blood cell analyzer 200 is further configured to perform at least one of the following tests on the blood sample: reticulocyte count test, hemoglobin test, red blood cell test, and platelet test.

[0201] As an embodiment, the blood cell analyzer 200 performs white blood cell differential counting and reticulocyte counting tests on the optical detection test fluid (at least made of a sample) flowing through the detection area of ​​the flow chamber under the influence of the sheath fluid through the optical detection component.

[0202] As an embodiment, the blood cell analyzer 200 performs red blood cell detection and platelet detection on the impedance detection test fluid (at least made of a sample) through the impedance detection component.

[0203] As an embodiment, the control component 500 includes a first controller provided in the liquid chromatography device and a second controller provided in the blood cell analyzer 200 .

[0204] The present embodiment further provides a liquid chromatography device, comprising a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160, and a first controller. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first connection state and a second connection state: in the first connection state, the reversing valve 130 connects the sample supply assembly 110 and the test solution preparation channel 140 and connects the liquid-phase fluid supply assembly 120110 and the chromatographic column 150; in the second connection state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120110, the test solution preparation channel 140, and the chromatographic column 150; the sample supply assembly 110 is used to supply the sample to the test solution preparation channel 140 via the reversing valve 130. The test liquid is made of a sample; the liquid-phase fluid supply component 120110 is used to drive the test liquid in the test liquid preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence; the chromatographic column 150 is used to adsorb the test liquid, and to supply the liquid-phase fluid to elute the test liquid to form a test liquid; the detector 160 is used to analyze the test liquid flowing out of the chromatographic column 150; the liquid-phase fluid supply component 120110 includes a first drive device 121 and an energy storage device 122, the first drive device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150, the energy storage device 122 is arranged between the first drive device 121 and the reversing valve 130, and the energy storage device 122 is used to store potential energy or release the stored potential energy. The first controller is configured to: during the execution of a chromatographic analysis project for a sample, control the first driving device 121 to drive the liquid phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column 150, and control the energy storage device 122 to store potential energy through the pressure of the liquid phase fluid; after completing the chromatographic analysis project for a sample and when executing the chromatographic analysis project for the next sample, control the energy storage device 122 to release the potential energy stored during the execution of the chromatographic analysis project for a sample to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0205] As an embodiment, the liquid-phase fluid supply assembly 120 further includes a locking and releasing device 123, which is used to lock and release the energy storage device 122. The locking and releasing device 123 can switch between a locked state and a released state. In a specific application, when the locking and releasing device 123 is in the released state, the energy storage device 122 can store potential energy under the pressure of the liquid-phase fluid; when the locking and releasing device 123 is in the locked state, the energy storage device 122 is locked and the potential energy stored in the energy storage device 122 cannot be released; when the locking and releasing device 123 switches from the locked state to the released state, the potential energy stored in the energy storage device 122 can be released. In this embodiment, an energy storage device 122 and a locking and releasing device 123 are provided in the liquid-phase fluid supply component 120, and the locking and releasing device 123 is provided to release the potential energy storage and release component 1222 of the energy storage device 122 in the released state to allow the energy storage device 122 to store and release potential energy under the pressure of the liquid-phase fluid, and the locking and releasing device 123 is provided to lock the potential energy storage and release component 1222 in the locked state to prevent the energy storage device 122 from releasing the stored potential energy, so that the liquid-phase fluid supply component 120 has the function of storing and releasing potential energy in addition to providing liquid-phase fluid of a certain pressure.

[0206] As an embodiment, the energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially disposed in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid phase fluid to flow through. The potential energy storage and release component 1222 is at least partially capable of moving relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy.

[0207] In one embodiment, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the housing 1221 and releasing the stored potential energy. In the released state, the potential energy storage and release component 1222 can move relative to the housing 1221 under the pressure of the liquid fluid to store potential energy. When the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the housing 1221 and release the stored potential energy. In this embodiment, the locking and releasing device 123 locks the potential energy storage and release component 1222 by directly applying a force to the potential energy storage and release component 1222.

[0208] As an embodiment, the above-mentioned control of the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid includes: controlling the lock-release device 123 to be in a released state to allow the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid. The above-mentioned control of the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample after completing the chromatographic analysis project of a sample and when executing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of a sample, controlling the lock-release device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow; after the lock-release device 123 switches to the locked state, when executing the chromatographic analysis project of the next sample, controlling the lock-release device 123 to switch from the locked state to the released state to allow the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample. In this embodiment, after completing the chromatographic analysis project of a sample, the locking device 123 is switched from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, thereby achieving the effect of storing energy and maintaining pressure. When executing the chromatographic analysis project of the next sample, the energy stored in the previous sample can be used to assist the liquid phase fluid in quickly building up pressure; of course, in specific applications, as an alternative implementation scheme, when two adjacent samples are continuously injected or the injection interval is very small (for example, less than the first preset time length described below), the pressure can also be maintained by controlling the first driving device 121 to keep driving the liquid phase fluid to flow, without the need for the locking device 123 to switch from the released state to the locked state, but this may result in a large consumption of the liquid phase fluid.

[0209] As a first embodiment of a liquid chromatography device, the liquid chromatography device is a liquid chromatography analyzer 100, which includes a sample supply component 110, a liquid phase fluid supply component 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150 and a detector 160. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first connection state and a second connection state: in the first connection state, the reversing valve 130 is connected to the sample. The supply assembly 110 and the test solution preparation channel 140 are connected to the liquid phase fluid supply assembly 120 and the chromatographic column 150. In the second connection state, the reversing valve 130 connects the liquid phase fluid supply assembly 120, the test solution preparation channel 140 and the chromatographic column 150; the sample supply assembly 110 is used to draw a blood sample from the sample container and supply a test solution made from at least part of the drawn blood sample to the test solution preparation channel 140 through the reversing valve 130; the liquid phase fluid supply assembly 120 is used to drive the test solution preparation channel 140 through the liquid phase fluid. The test solution in the channel 140 is transported to the chromatographic column 150, and is used to drive the liquid phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence; the chromatographic column 150 is used to adsorb the test solution and to supply the liquid phase fluid to elute the test solution to form a test solution; the detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150; the liquid phase fluid supply assembly 120 includes a first driving device 121, an energy storage device 122 and a lock and release device 123, the first driving device 121 is used to drive the liquid phase fluid to reversing direction The valve 130 and the chromatographic column 150 flow, the energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130, the energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222, the potential energy storage and release component 1222 is at least partially arranged in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid phase fluid to flow through, the potential energy storage and release component 1222 is at least partially able to move relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the shell 1221, thereby preventing the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release component 1222 can move relative to the shell 1221 under the pressure of the liquid fluid to store potential energy, and, when the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the shell 1221, thereby allowing the potential energy storage and release component 1222 to release the stored potential energy.The control component 500 is further configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column 150, and control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the housing 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after the completion of the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to be subjected to the chromatographic analysis project, then control the locking and releasing device 123 to switch from the released state to the released state. The first drive device 121 is controlled to stop driving the liquid phase fluid to flow. After the lock-release device 123 is switched to the locked state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, the lock-release device 123 is controlled to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the housing 1221 to release the stored potential energy, thereby assisting in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The working principle and other parts of the liquid chromatograph analyzer 100 can refer to the introduction of the liquid chromatograph analyzer 100 in the sample analysis system 10 above, and will not be described in detail here.

[0210] When the liquid chromatography device is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0211] In one embodiment, the hemolysis treatment solution includes at least one of the following liquids: a hemolytic agent containing a surfactant that lyses and disrupts red blood cells in the sample; and deionized water, pure water, or distilled water that swells and disrupts red blood cells in the sample through osmotic pressure. The hemolytic agent containing a surfactant primarily lyses the red blood cells, causing them to release hemoglobin, thereby processing the whole blood sample into a test solution. Deionized water, pure water, or distilled water primarily swells and disrupts the red blood cells in the whole blood sample through osmotic pressure, causing them to release hemoglobin, thereby also processing the whole blood sample into a test solution.

[0212] As an embodiment, when the hemolysis treatment liquid is a hemolytic agent containing a surfactant to lyse and break red blood cells in the sample, the sample infusion path 113143 is used to draw the hemolytic treatment liquid from the hemolytic agent container 40 to the first reaction container 112 .

[0213] As a second embodiment of a liquid chromatography apparatus, the liquid chromatography apparatus is a liquid chromatography-mass spectrometry analyzer 101, the detector 160 is a mass spectrometer detector 160, and the liquid chromatography apparatus includes a chromatography device 1010 and a pre-treatment device 1011. The chromatography device 1010 includes a sample supply assembly 110, a liquid fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, and a chromatographic column 150. The pre-treatment device 1011 is used to pre-treat a sample from a sample container using at least one of magnetic separation, solid phase extraction, liquid-liquid extraction, and protein precipitation to obtain the test solution. The sample supply assembly 110 is used to transfer at least a portion of the test solution obtained by the pre-treatment device 1011 to the test solution preparation channel 140.

[0214] As an embodiment, the liquid chromatography-mass spectrometry apparatus 101 further includes a sample storage device 1012 for placing a sample container containing a sample to facilitate sample loading. The pre-treatment device 1011 is used to pre-treat the sample in the sample container of the sample storage device 1012 to obtain a test solution.

[0215] As a first embodiment in which the pre-treatment device 1011 employs a magnetic separation method, the pre-treatment device 1011 employs a magnetic separation method to pre-treat the sample. The pre-treatment device 1011 includes a magnetic separation component 1011a, a magnetic bead elution component 1011b, a reagent dispensing component 1011d, and a liquid transfer component 1011e. The liquid transfer component 1011e is used to aspirate at least a portion of the sample from the sample container of the sample storage device 1012 and dispense all or part of the aspirated sample into a second reaction container. The reagent dispensing component 1011d is used to dispense the internal standard reagent and the first magnetic bead reagent into the second reaction container, respectively. The magnetic separation component 1011a is used to perform magnetic separation and cleaning on a first mixed solution in the second reaction container containing at least the sample, the internal standard reagent, and the first magnetic bead reagent to obtain a first clear solution and a first magnetic bead solution, and to aspirate and drain the first clear solution from the second reaction container. The magnetic bead elution component 1011b is used to elute the first magnetic bead solution in the second reaction container to obtain a test solution. The sample supply assembly 110 is used to aspirate at least a portion of the test solution from the second reaction container and transfer all or part of the aspirated test solution to the test solution preparation channel 140. The reagent dispensing component 1011d and the liquid transfer component 1011e may be two separate components or a single component. In this embodiment, magnetic beads are used to adsorb target analytes, which are present in the first magnetic bead solution.

[0216] As an embodiment, the pre-treatment device 1011 further includes a reagent storage component 1011c, and the reagent dispensing component 1011d is used to absorb at least part of the first magnetic bead reagent from the reagent container from the reagent storage component 1011c and distribute all or part of the absorbed first magnetic bead reagent to the second reaction container.

[0217] As an embodiment, the pretreatment device 1011 also includes a reaction container providing component 1011f and a reaction container transfer component. The reaction container providing component 1011f is used to provide a second reaction container, and the reaction container transfer component is used to transfer the second reaction container from the reaction container providing component 1011f to the magnetic separation component 1011a and the magnetic bead elution component 1011b respectively.

[0218] As an embodiment, the pre-processing device 1011 also includes a mixing component; the first controller is also configured to control the pre-processing device 1011 to perform the following pre-processing actions: control the pipetting component 1011e to absorb at least part of the sample from the sample container from the sample storage device 1012 and distribute all or part of the absorbed sample to the second reaction container; control the reagent dispensing component 1011d to distribute the internal standard reagent to the second reaction container; control the mixing component to mix the sample and the internal standard reagent in the second reaction container to obtain a second mixed liquid; control the reagent dispensing component 1011d to distribute the first magnetic bead reagent to the second mixed liquid in the second reaction container to obtain a first mixed liquid; control the magnetic separation component 1011a to perform magnetic separation and cleaning on the first mixed liquid in the second reaction container to obtain a first clear liquid and a first magnetic bead liquid; control the magnetic separation component 1011a to absorb and discharge the first clear liquid in the second reaction container; control the magnetic bead elution component 1011b to elute the first magnetic bead liquid in the second reaction container to obtain a test solution.

[0219] As a second embodiment of the pre-treatment device 1011 using a magnetic separation method, the pre-treatment device 1011 uses a magnetic separation method to pre-treat the sample; the pre-treatment device 1011 includes a magnetic separation component 1011a, a reagent dispensing component 1011d and a pipetting component 1011e; wherein the pipetting component 1011e is used to absorb at least part of the sample from the sample container from the sample storage device 1012 and distribute all or part of the absorbed sample to the second reaction container; the reagent dispensing component 1011d is used to distribute the internal standard reagent and the second magnetic beads The reagents are distributed to the second reaction container. The magnetic separation component 1011a is used to perform magnetic separation and cleaning on the third mixed solution in the second reaction container, which contains at least the sample, the internal standard reagent, and the second magnetic bead reagent, to obtain a second clear solution and a second magnetic bead solution. The second clear solution is used as the test solution. The sample supply assembly 110 is used to aspirate at least a portion of the test solution from the second reaction container and transfer all or part of the aspirated test solution to the test solution preparation channel 140. The reagent dispensing component 1011d and the liquid transfer component 1011e can be two separate components or a single component. In this embodiment, the magnetic beads are used to adsorb impurities, and the target analyte is in the second clear solution.

[0220] This embodiment also provides a control method for a liquid chromatography device, which can specifically be a control method for a liquid chromatography analyzer 100. The control method includes the following steps: within a first preset time period after completing a chromatographic analysis project of a blood sample, if no information is obtained that other blood samples need to perform chromatographic analysis projects, the locking and releasing device 123 is controlled to switch from a released state to a locked state to prevent the potential energy storage and release component 1222 from releasing the stored potential energy, and the first driving device 121 is controlled to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 is switched to the locked state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from a locked state to a released state, so that the potential energy storage and release component 1222 releases the stored potential energy to assist in driving the liquid phase fluid to flow toward the chromatographic column 150.

[0221] As an embodiment, the above-mentioned control method also includes: before executing the first chromatographic analysis project after the liquid chromatograph analyzer 100 is turned on, first controlling the first driving device 121 to start and keep running for a third preset time period so that the pressure of the liquid fluid flowing to the chromatographic column 150 reaches the target pressure value or the target pressure range; during the execution of the chromatographic analysis project, controlling the first driving device 121 to drive the liquid fluid to flow at the target pressure value or the pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column 150.

[0222] As an embodiment, in the above-mentioned control method, if the information is obtained that a blood sample needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from a locked state to a released state, including: first controlling the first driving device 121 to start and keep running for a second preset time, so that the pressure of the liquid fluid flowing to the chromatographic column 150 is greater than zero and less than the target pressure value or less than the lower limit value of the target pressure range, and then controlling the locking and releasing device 123 to switch from the locked state to the released state.

[0223] As an embodiment, the above-mentioned control method also includes: after controlling the lock-release device 123 to switch from the locked state to the released state, first controlling the first driving device 121 to continue to run for the fourth preset time length, so that the pressure of the liquid-phase fluid flowing to the chromatographic column 150 approximately reaches the target pressure value or the target pressure range, and then controlling the reversing valve 130 to switch to a state connecting the liquid-phase fluid supply component 120, the test liquid preparation channel 140 and the chromatographic column 150, so that the liquid-phase fluid supply component 120 drives the test liquid in the test liquid preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid; wherein the sum of the second preset time length and the fourth preset time length is less than the third preset time length.

[0224] The specific principles and implementation of the control method provided in this embodiment are similar to those described in the above-mentioned sample analysis system 10 and will not be described in detail here.

[0225] This embodiment also provides a computer-readable storage medium storing a computer program. When executed by a processor (e.g., the control component 500 described above), the computer-readable storage medium causes the processor to implement the steps of the control method for the liquid chromatograph analyzer 100 described above. The computer-readable storage medium may be an internal storage unit of the sample analysis system 10 described above, such as a hard disk or memory of the sample analysis system 10; or, the computer-readable storage medium may be an external storage device of the sample analysis system 10, such as a plug-in hard disk, a smart media card (SMC), a secure digital (SD) card, a flash memory card, etc., provided in the sample analysis system 10.

[0226] In this embodiment, when the liquid chromatograph analyzer 100 stops measuring, the elastic potential energy in the energy storage device 122 is stored through the electromechanical structure (a structure composed of a motor, a transmission component 1233, and a locking component 1232), and the pressure of the liquid system instantly drops to zero pressure or close to zero pressure, and the liquid phase fluid stops flowing, achieving rapid pressure relief, and the liquid phase fluid is stored in the energy storage device 122 and / or in the pipeline. When the measurement is started next time, the electromechanical structure quickly releases the elastic potential energy in the energy storage device 122, and the elastic potential energy quickly recovers its deformation, squeezing the liquid phase fluid to flow quickly, thereby achieving rapid pressure buildup and reducing the consumption of liquid phase fluid during the pressure buildup process. Since the liquid phase fluid is also stored in the energy storage device 122 during the potential energy locking process, the consumption of liquid phase fluid is further reduced.

[0227] This embodiment has the following significant beneficial effects: (1) by storing and releasing potential energy, the effects of rapid pressure buildup and saving of liquid fluid are achieved; (2) the liquid chromatograph analyzer 100 can achieve the effect of immediate measurement in the cascade system and the assembly line; (3) the locking force of the energy storage device 122 is provided by the self-locking of the screw transmission pair, and the torque of the motor only needs to be able to drive the locking component 1232 to move under no-load, and there is no need to overcome the force of the elastic element 1222b. Therefore, the torque output by the motor can be set to be much smaller than the torque required to pull the deformed elastic element 1222b, and the structure is simple and the cost is low.

[0228] Example 2:

[0229] The sample analysis system 10, liquid chromatography equipment, and control method for the liquid chromatography equipment provided in this embodiment differ from those in the first embodiment mainly in the different protection focuses, which are specifically reflected in the following: in the first embodiment, the focus is on protecting the control timing of the re-establishment of pressure lock and release device 123 in the intermittent injection scenario; while in this embodiment, the focus is on protecting the sample in the intermittent injection scenario. The immediate detection scheme.

[0230] Specifically, the sample analysis system 10 provided in this embodiment includes a sample input device 400, a liquid chromatograph 100, a hematology analyzer 200, a sample transfer device 300, an information acquisition device 600, and a control component 500. The sample input device 400 is used to receive at least a sample container containing a blood sample to load the blood sample. The liquid chromatograph 100 is used to draw a blood sample from the sample container and perform chromatographic analysis on at least a portion of the drawn blood sample. The hematology analyzer 200 is used to draw a blood sample from the sample container and perform hematology analysis on at least a portion of the drawn blood sample. The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatograph 100, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the hematology analyzer 200. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected. The information acquisition device 600 is used to obtain information indicating the type of test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of test item of the blood sample in the sample container based on the information indicating the type of test item of the blood sample in the sample container fed back by the information acquisition device 600; and, based on the type of test item of the blood sample in the sample container, control the sample transfer device 300 to transfer the sample container to the liquid chromatograph analyzer 100 and / or the blood cell analyzer 200 for sample aspiration.

[0231] As one embodiment, the liquid chromatograph analyzer 100 includes a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, and a detector 160. The reversing valve 130 has a switchable first and second communication states. In the first communication state, the reversing valve 130 connects the sample supply assembly 110 with the test solution preparation channel 140 and the liquid-phase fluid supply assembly 120 with the chromatographic column 150. In the second communication state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150, with the chromatographic column 150 connected between the reversing valve 130 and the detector 160. The sample supply assembly 110 is used to draw a blood sample from a sample container and supply a test solution prepared from at least a portion of the drawn blood sample to the test solution preparation channel 140 via the reversing valve 130. The liquid-phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to the chromatographic column 150 using a liquid-phase fluid, and to drive the liquid-phase fluid to flow sequentially through the reversing valve 130 and the chromatographic column 150. The chromatographic column 150 is used to adsorb the test solution and to supply the liquid-phase fluid to elute the test solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150.

[0232] As an embodiment, the liquid-phase fluid supply component 120 includes a first driving device 121, an energy storage device 122 and a locking and releasing device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially arranged in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid-phase fluid to flow through. The potential energy storage and release component 1222 is at least partially able to move relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state.

[0233] As an embodiment, the control component 500 is also configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to flow to elute the test solution adsorbed on the chromatographic column 150, and control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the shell 1221 through the pressure of the liquid phase fluid to store potential energy; within a first preset time after completing the chromatographic analysis project of a blood sample, if no information is obtained that there are other blood samples that need to perform chromatographic analysis projects, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the shell 1221 to prevent it from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid phase fluid to flow. When the lock-and-release device 123 is in the locked state and the reversing valve 130 is in the first connected state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, the sample supply assembly 110 is controlled to perform the following test solution preparation action: the blood sample is drawn from the sample container and distributed to the first reaction container 112, and the test solution composed of at least the blood sample and the hemolytic agent in the first reaction container 112 is transported to the sample preparation channel through the reversing valve 130. While the sample supply assembly 110 is performing the test solution preparation action, the first driving device 121 is controlled to start and operate, and the lock-and-release device 123 is controlled to switch from the locked state to the released state, causing the potential energy storage and release assembly 1222 to move relative to the housing 1221 to release the stored potential energy, thereby assisting in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. After the sample supply assembly 110 completes the test solution preparation operation, the reversing valve 130 is controlled to switch from the first connection state to the second connection state, so that the liquid phase fluid supply assembly 120 drives the test solution in the test solution preparation channel 140 to be transported to the chromatographic column 150 through the liquid phase fluid.

[0234] As an embodiment, the control component 500 is further configured to: control the sample supply component 110 to perform the following test solution preparation actions within a fifth preset time: draw the blood sample from the sample container and distribute it to the first reaction container 112, and transport the test solution made of at least the blood sample and the hemolytic agent in the first reaction container 112 to the sample preparation channel through the reversing valve 130; when the lock and release device 123 is in a locked state, if information is obtained that a blood sample needs to be subjected to a chromatographic analysis project, control the liquid phase fluid supply component 120 to perform within a sixth preset time. Complete the following pressure building action: control the first driving device 121 to start and run, control the locking and releasing device 123 to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply component 120 to drive the liquid-phase fluid to flow to the chromatographic column 150 reaches the target pressure value or the target pressure range within the fifth preset time length; in the process of executing the chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow at the target pressure value or the pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column 150; the sixth preset time length is less than the fifth preset time length.

[0235] In one embodiment, the first controller is further configured to: before executing the first chromatographic analysis project after the liquid chromatograph 100 is powered on, control the first driving device 121 to start and run for a third preset time period, so that the pressure of the liquid fluid flowing to the chromatographic column 150 reaches a target pressure value or a target pressure range. The sixth preset time period is shorter than the third preset time period.

[0236] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in the first embodiment and will not be described in detail here.

[0237] Example 3:

[0238] The sample analysis system 10, liquid chromatography device, and control method for the liquid chromatography device provided in this embodiment differ from those in the first embodiment primarily in that this embodiment focuses on limiting the energy storage device 122 of the liquid chromatography device to store energy during the chromatographic analysis of the current sample and release the energy when performing the chromatographic analysis of the next sample.

[0239] Specifically, the liquid chromatography apparatus provided in this embodiment includes a sample supply assembly 110, a liquid phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160, and a first controller. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first connection state and a second connection state: in the first connection state, the reversing valve 130 connects the sample supply assembly 110 and the test solution preparation channel 140 and connects the liquid phase fluid supply assembly 120. 0 and the chromatographic column 150, in the second connection state, the reversing valve 130 connects the liquid-phase fluid supply component 120, the test liquid preparation channel 140 and the chromatographic column 150; the sample supply component 110 is used to supply at least a test liquid made of a sample to the test liquid preparation channel 140 through the reversing valve 130; the liquid-phase fluid supply component 120 is used to drive the test liquid in the test liquid preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence; the chromatographic column 150 is used to The first controller is configured to: During the execution of a chromatographic analysis project for a sample, the first driving device 121 is controlled to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column 150, and the energy storage device 122 is controlled to store potential energy through the pressure of the liquid phase fluid. After completing the chromatographic analysis project for a sample and when executing the chromatographic analysis project for the next sample, the energy storage device 122 is controlled to release the potential energy stored during the execution of the chromatographic analysis project for the sample to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0240] As an embodiment, the liquid-phase fluid supply assembly 120 also includes a locking and releasing device 123, which can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the energy storage device 122 to lock the energy storage device 122, thereby preventing the energy storage device 122 from releasing the stored potential energy; in the released state, the energy storage device 122 can store potential energy under the pressure of the liquid-phase fluid, and, when the locking and releasing device 123 removes the force applied to the energy storage device 122, the energy storage device 122 is released, thereby allowing the energy storage device 122 to release the stored potential energy.

[0241] As an embodiment, the above-mentioned control of the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid includes: controlling the lock-release device 123 to be in a released state to allow the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid. The above-mentioned control of the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample after completing the chromatographic analysis project of a sample and when executing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of a sample, controlling the lock-release device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow; after the lock-release device 123 switches to the locked state, when executing the chromatographic analysis project of the next sample, controlling the lock-release device 123 to switch from the locked state to the released state to allow the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample.

[0242] As an embodiment, after completing the chromatographic analysis project of a sample, the above-mentioned control of the locking and releasing device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and the control of the first driving device 121 to stop driving the flow of the liquid-phase fluid includes: within a first preset time after completing the chromatographic analysis project of a sample, if no information is obtained that there are other samples that need to perform chromatographic analysis projects, the control of the locking and releasing device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and the control of the first driving device 121 to stop driving the flow of the liquid-phase fluid. The above-mentioned process includes: after the lock-release device 123 is switched to the locked state, when executing the chromatographic analysis project of the next sample, controlling the lock-release device 123 to switch from the locked state to the released state, so that the energy storage device 122 releases the potential energy stored in the process of executing the chromatographic analysis project of a sample, including: after the lock-release device 123 is switched to the locked state, if information is obtained that a chromatographic analysis project needs to be executed for a sample, controlling the lock-release device 123 to switch from the locked state to the released state, so that the energy storage device 122 releases the potential energy stored in the process of executing the chromatographic analysis project of a sample, so as to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0243] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0244] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0245] This embodiment further provides a sample analysis system 10, which includes:

[0246] A sample input device 400, the sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0247] a first analyzer, wherein the first analyzer is the aforementioned liquid chromatography device, the liquid chromatography device being used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0248] a second analyzer, the second analyzer being configured to draw a sample from a sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0249] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device. The second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0250] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0251] As an embodiment, the second analyzer is a blood cell analyzer 200, which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0252] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0253] The control method for a liquid chromatography device provided in this embodiment includes the following steps: during the execution of a chromatographic analysis project for a sample, controlling the first driving device 121 to drive the flow of liquid-phase fluid to elute a test solution adsorbed on the chromatographic column 150 and composed of at least the sample, and controlling the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid; after completing the chromatographic analysis project for a sample and before executing the chromatographic analysis project for the next sample, controlling the energy storage device 122 to release the potential energy stored during the execution of the chromatographic analysis project for the sample to assist in driving the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0254] As an embodiment, the above-mentioned control of the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid includes: controlling the lock-release device 123 to be in a released state to allow the energy storage device 122 to store potential energy through the pressure of the liquid-phase fluid. The above-mentioned control of the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample after completing the chromatographic analysis project of a sample and when executing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of a sample, controlling the lock-release device 123 to switch from the released state to the locked state to prevent the energy storage device 122 from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow; after the lock-release device 123 switches to the locked state, when executing the chromatographic analysis project of the next sample, controlling the lock-release device 123 to switch from the locked state to the released state to allow the energy storage device 122 to release the potential energy stored in the process of executing the chromatographic analysis project of a sample.

[0255] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in the first and second embodiments and will not be described in detail here.

[0256] Example 4:

[0257] The sample analysis system 10, liquid chromatography equipment, and control method of the liquid chromatography equipment provided in this embodiment differ from those in the first embodiment mainly in that the locking method of the potential energy storage and release component 1222 by the locking and releasing device 123 may be different, which is specifically reflected in: in the first embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by applying a force; while in this embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by abutting.

[0258] Specifically, the liquid chromatography device provided in this embodiment includes a sample supply component 110, a liquid-phase fluid supply component 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160 and a first controller. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first and second communication states: in the first communication state, the reversing valve 130 connects the sample supply component 110 and the test solution preparation channel 140 and connects the liquid-phase fluid supply component 120 and the chromatographic column 150; in the second communication state, the reversing valve 130 connects the liquid-phase fluid supply component 120, the test solution preparation channel 140 and the chromatographic column 150; the sample supply component 110 is used to supply a test solution made of at least a sample to the test solution preparation channel 140 via the reversing valve 130. The liquid phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to be transported to the chromatographic column 150 through the liquid phase fluid, and to drive the liquid phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence; the chromatographic column 150 is used to adsorb the test solution and to supply the liquid phase fluid to elute the test solution to form a test solution; the detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150; the liquid phase fluid supply assembly 120 includes a first driving device 121, an energy storage device 122 and a lock and release device 123, the first driving device 121 21 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially arranged in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for the liquid-phase fluid to flow through. The potential energy storage and release component 1222 is at least partially able to move relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 abuts against the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing it from moving relative to the shell 1221, so as to prevent the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release component 1222 can move relative to the shell 1221 through the pressure of the liquid fluid to store potential energy, and, when the locking and releasing device 123 is separated from the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the shell 1221, so as to allow the potential energy storage and release component 1222 to release the stored potential energy.The first controller is configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column 150, control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the shell 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after the completion of the chromatographic analysis project of a sample, if no information is obtained that other samples need to perform chromatographic analysis projects, then control the locking and releasing device 123 from the released state Switch to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the shell 1221, thereby preventing it from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 is switched to the locked state, if information is obtained that there is a sample that needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the shell 1221 and release the stored potential energy to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0259] As an embodiment, the potential energy storage and release component 1222 has a locking portion 1222d extending outside the shell 1221. The locking and releasing device 123 locks the potential energy storage and release component 1222 by abutting and limiting the locking portion 1222d. The locking and releasing device 123 releases the potential energy storage and release component 1222 by disengaging to release the locking portion 1222d.

[0260] As an embodiment, the locking and releasing device 123 includes a power component 1231, a locking component 1232 and a transmission component 1233 that is transmission-connected between the power component 1231 and the locking component 1232. The transmission component 1233 has a self-locking capability. When the locking and releasing device 123 is in a locked state, the power component 1231 is in a stopped state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233 to abut against the locking potential energy storage and release component 1222.

[0261] As an embodiment, the first controller is also configured to: control the sample supply component 110 to perform the following test liquid preparation action within the fifth preset time: draw the sample from the sample container and distribute it to the first reaction container 112, and transport the test liquid made of at least the sample and the hemolytic agent in the first reaction container 112 to the sample preparation channel through the reversing valve 130; when the locking and releasing device 123 is in a locked state, if information is obtained that there is a sample that needs to perform a chromatographic analysis project, the liquid-phase fluid supply component 120 is controlled to perform the following pressure building action within the sixth preset time: control the first driving device 121 to start and run, and control the locking and releasing device 123 to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply component 120 driving the liquid-phase fluid to flow to the chromatographic column 150 reaches the target pressure value or the target pressure range within the fifth preset time; in the process of executing the chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow at the target pressure value or the pressure value within the target pressure range to elute the test liquid adsorbed on the chromatographic column 150; the sixth preset time is less than the fifth preset time.

[0262] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0263] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0264] This embodiment further provides a sample analysis system 10, which includes:

[0265] The sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0266] a first analyzer, which is the aforementioned liquid chromatography device, and is used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0267] a second analyzer, the second analyzer being configured to draw a sample from the sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0268] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0269] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0270] As an embodiment, the second analyzer is a blood cell analyzer 200 , which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0271] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0272] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in Embodiments 1 to 3 and will not be described in detail here.

[0273] Embodiment 5:

[0274] The sample analysis system 10, liquid chromatography equipment, and control method of the liquid chromatography equipment provided in this embodiment differ from those in the first embodiment mainly in that the locking method of the potential energy storage and release component 1222 by the locking and releasing device 123 may be different, which is specifically reflected in: in the first embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by applying a force; while in this embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by a non-liquid path locking method.

[0275] Specifically, the liquid chromatography apparatus provided in this embodiment includes a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160, and a first controller. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first and second communication states: in the first communication state, the reversing valve 130 connects the sample supply assembly 110 with the test solution preparation channel 140 and the liquid-phase fluid supply assembly 120 with the chromatographic column 150; in the second communication state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150. The sample supply assembly 110 is configured to supply a test solution composed of at least a sample to the test solution preparation channel 140 via the reversing valve 130. The liquid-phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to the chromatographic column 150 using a liquid-phase fluid, and to drive the liquid-phase fluid to flow sequentially through the reversing valve 130 and the chromatographic column 150. The chromatographic column 150 is used to adsorb the test solution and to supply the liquid-phase fluid to elute the test solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150. The liquid-phase fluid supply assembly 120 includes a first driving device 121, an energy storage device 122 and a lock-and-release device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 includes a shell 1221 and a potential energy storage and release assembly 1222. The potential energy storage and release assembly 1222 is at least partially arranged in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid-phase fluid to flow through. The potential energy storage and release assembly 1222 is at least partially able to move relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 locks the potential energy storage and release component 1222 by a non-liquid path locking method, thereby preventing it from moving relative to the shell 1221, so as to prevent the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release component 1222 can move relative to the shell 1221 by the pressure of the liquid fluid to store potential energy, and the locking and releasing device 123 releases the potential energy storage and release component 1222 by a non-liquid path conduction method, thereby allowing the potential energy storage and release component 1222 to release the stored potential energy.The first controller is configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to elute the test solution adsorbed on the chromatographic column 150, control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the shell 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after the completion of the chromatographic analysis project of a sample, if no information is obtained that other samples need to perform chromatographic analysis projects, then control the locking and releasing device 123 from the released state Switch to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the shell 1221, thereby preventing it from releasing the stored potential energy, and controlling the first driving device 121 to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 is switched to the locked state, if information is obtained that there is a sample that needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the shell 1221 and release the stored potential energy to assist in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0276] As an embodiment, the potential energy storage and release component 1222 has a locking portion 1222d extending outside the shell 1221. The locking and releasing device 123 locks the potential energy storage and release component 1222 by abutting and limiting the locking portion 1222d. The locking and releasing device 123 releases the potential energy storage and release component 1222 by disengaging to release the locking portion 1222d.

[0277] As an embodiment, the locking and releasing device 123 includes a power component 1231, a locking component 1232 and a transmission component 1233 that is transmission-connected between the power component 1231 and the locking component 1232. The transmission component 1233 has a self-locking capability. When the locking and releasing device 123 is in a locked state, the power component 1231 is in a stopped state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233 to abut against the locking potential energy storage and release component 1222.

[0278] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0279] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0280] This embodiment further provides a sample analysis system 10, which includes:

[0281] The sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0282] a first analyzer, which is the aforementioned liquid chromatography device, and is used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0283] a second analyzer, the second analyzer being configured to draw a sample from the sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0284] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0285] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0286] As an embodiment, the second analyzer is a blood cell analyzer 200 , which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0287] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0288] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in Embodiments 1 to 4 and will not be described in detail here.

[0289] Example 6:

[0290] 1 to 4 and 12 , the sample analysis system 10, liquid chromatography equipment, and control method for liquid chromatography equipment provided in this embodiment differ from those in the first embodiment mainly in the different protection focuses and the different locking methods for the energy storage device 122, which are specifically reflected in the following: In the first embodiment, the focus is on protecting the locking and releasing device 123 by applying a force to lock the potential energy storage and release component 1222 and removing the force to achieve rapid pressure buildup; whereas in the present embodiment, the focus is on protecting the pressure of the liquid fluid during the locking and pressure building process, and the locking method of the energy storage device 122 can be a liquid circuit locking method.

[0291] Specifically, the liquid chromatography apparatus provided in this embodiment includes a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160, and a first controller. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first and second communication states: in the first communication state, the reversing valve 130 connects the sample supply assembly 110 with the test solution preparation channel 140 and the liquid-phase fluid supply assembly 120 with the chromatographic column 150; in the second communication state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150. The sample supply assembly 110 is configured to supply a test solution composed of at least a sample to the test solution preparation channel 140 via the reversing valve 130. The liquid-phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to the chromatographic column 150 via the liquid-phase fluid, and to drive the liquid-phase fluid to flow sequentially through the reversing valve 130 and the chromatographic column 150. The chromatographic column 150 is used to adsorb the test solution and to supply the liquid-phase fluid to elute the test solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150.

[0292] As an embodiment, the liquid phase fluid supply assembly 120 includes a first driving device 121, an energy storage device 122 and a lock-release device 123. The first driving device 121 is used to drive the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 includes a housing 1221 and a potential energy storage and release assembly 1222. The potential energy storage and release assembly 1222 is at least partially arranged in the housing 1221 and is separated in the housing 1221 to form a liquid cavity 1223 for the liquid phase fluid to flow through. The housing 1221 is formed with A liquid inlet 1221a is provided for supplying liquid phase fluid into the liquid cavity 1223, and a liquid outlet 1221b is provided for supplying liquid phase fluid out of the liquid cavity 1223. The potential energy storage and release component 1222 is at least partially capable of moving relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 prevents the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the locking and releasing device 123 allows the potential energy storage and release component 1222 to store potential energy and release the stored potential energy.

[0293] As an embodiment, the first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to flow at a target pressure value or a pressure value within a target pressure range to elute the test solution adsorbed on the chromatographic column 150, and control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the housing 1221 under the pressure of the liquid phase fluid to store potential energy; within a first preset time after completing a chromatographic analysis project for a sample, if no other sample is obtained that needs to perform a chromatographic analysis project, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release component 122 from moving relative to the housing 1221. 2 moves relative to the housing 1221 to prevent it from releasing the stored potential energy, controls the first driving device 121 to stop driving the liquid phase fluid to flow, so that the pressure of the liquid phase fluid at the liquid outlet 1221b is maintained at a first pressure value. When the lock-release device 123 is in the locked state, if information is obtained that a sample needs to be subjected to a chromatographic analysis project, controls the lock-release device 123 to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the housing 1221 to release the stored potential energy, thereby assisting in driving the liquid phase fluid to flow toward the reversing valve 130 and the chromatographic column 150; wherein the first pressure value is substantially equal to the target pressure value or within the target pressure range, or the first pressure value is substantially equal to zero.

[0294] As an embodiment, if information is obtained that a sample needs to perform a chromatographic analysis project, the locking and releasing device 123 is controlled to switch from a locked state to a released state, including: first controlling the first driving device 121 to start and keep running for a second preset time, so that the pressure of the fluid flowing to the chromatographic column 150 reaches the target pressure value or the target pressure range, and then controlling the locking and releasing device 123 to switch from the locked state to the released state; after the first driving device 121 starts running for the second preset time, and in the process of switching the locking and releasing device 123 from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a second pressure value, and the second pressure value is greater than the target pressure value or greater than the upper limit value of the target pressure range; after the locking and releasing device 123 switches from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is a third pressure value, and the third pressure value is approximately equal to the target pressure value or falls within the target pressure range.

[0295] As an embodiment, the control component 500 is also configured to: after controlling the lock and release device 123 to switch from the locked state to the released state, first control the first drive device 121 to continue to run for the fourth preset time length, so that the pressure of the liquid-phase fluid flowing to the chromatographic column 150 approximately reaches the target pressure value or target pressure range, and then control the reversing valve 130 to switch to the second connected state, so that the liquid-phase fluid supply component 120 drives the test liquid in the test liquid preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid; wherein the sum of the second preset time length and the fourth preset time length is less than the third preset time length.

[0296] As an embodiment, the lock-release device 123 includes a two-way valve 1235 connected between the energy storage device 122 and the reversing valve 130; the lock-release device 123 is in a locked state: the two-way valve 1235 is in a closed state; the lock-release device 123 is in a released state: the two-way valve 1235 is in an open state; the first pressure value is approximately equal to the target pressure value or within the target pressure range. In this embodiment, when the liquid chromatograph 100 stops measuring, the two-way valve 1235 is switched to a blocked state, and the pressure between the first drive device 121 and the two-way valve 1235 can be preserved. When the measurement is started next time, the two-way valve 1235 is switched to a conducting state, and the pressure between the first drive device 121 and the two-way valve 1235 can be quickly released, achieving rapid pressure buildup and reducing the consumption of liquid phase fluid during the pressure buildup process. Since the liquid phase fluid is also stored between the first drive device 121 and the two-way valve 1235 during the pressure preservation process, the consumption of liquid phase fluid is further reduced.

[0297] As an embodiment, the first pressure value is greater than or equal to 2 MPa and less than or equal to 10 MPa.

[0298] As an embodiment, the first pressure value is greater than or equal to 4 MPa and less than or equal to 6 MPa.

[0299] As an embodiment, the second analyzer is a blood cell analyzer 200 .

[0300] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0301] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0302] This embodiment further provides a sample analysis system 10, which includes:

[0303] The sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0304] a first analyzer, which is the aforementioned liquid chromatography device, and is used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0305] a second analyzer, the second analyzer being configured to draw a sample from the sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0306] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0307] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0308] As an embodiment, the second analyzer is a blood cell analyzer 200 , which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0309] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0310] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in Embodiments 1 to 5 and will not be described in detail here.

[0311] Embodiment seven:

[0312] 1 to 4 and 13 , the sample analysis system 10, liquid chromatography equipment, and control method for the liquid chromatography equipment provided in this embodiment differ from those in the first embodiment mainly in the different ways of energy storage and release in the intermittent injection scenario, which is specifically reflected in that: in the first embodiment, the energy storage device 122 is locked and released by the locking and releasing device 123 to achieve energy storage and release; while in this embodiment, energy storage and release is achieved by storing liquid fluid through the second driving device 126.

[0313] Specifically, the liquid chromatography device provided in this embodiment includes a sample supply component 110, a liquid fluid supply component 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, a detector 160 and a first controller, and the chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first and second connecting states: in the first connecting state, the reversing valve 130 connects the sample supply assembly 110 and the test liquid preparation channel 140, and connects the liquid-phase fluid supply assembly 120 and the chromatographic column 150; in the second connecting state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test liquid preparation channel 140, and the chromatographic column 150; the sample supply assembly 110 is used to supply at least a test liquid made of a sample to the test liquid preparation channel 140 through the reversing valve 130; the liquid-phase fluid supply assembly 120 is used to drive the test liquid in the test liquid preparation channel 140 to be transported to the chromatographic column 150 through the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve 130 and the chromatographic column 150 in sequence; the chromatographic column 150 is used to adsorb the test liquid and to supply the liquid-phase fluid to elute the test liquid to form a test liquid; the detector 160 is used to perform chromatographic analysis on the test liquid flowing out of the chromatographic column 150.

[0314] As an embodiment, the liquid-phase fluid supply assembly 120 includes a first driving device 121, a second driving device 126 and an energy storage device 122. The first driving device 121 is connected between the liquid-phase fluid container and the energy storage device 122. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is used to store potential energy when the first driving device 121 drives the liquid-phase fluid to flow. The second driving device 126 is connected to the liquid-phase fluid container and / or the energy storage device 122. The second driving device 126 is used to suck the liquid-phase fluid for storage and use the stored liquid-phase fluid to assist in driving the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150.

[0315] As an embodiment, the first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device 121 to drive the flow of liquid-phase fluid to elute the test solution adsorbed on the chromatographic column 150; within a first preset time period after completing the chromatographic analysis project of a sample, if no information is obtained that there are other samples that need to perform chromatographic analysis projects, control the second driving device 126 to start and run to aspirate the liquid-phase fluid and store it in the second driving device 126, and control the first driving device 121 to stop driving the flow of the liquid-phase fluid; after the second driving device 126 stores the liquid-phase fluid, if information is obtained that there are samples that need to perform chromatographic analysis projects, control the first driving device 121 to start and run to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150, and control the second driving device 126 to start and run to assist in driving the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150 through the stored liquid-phase fluid.

[0316] As an embodiment, the second driving device 126 is connected to the energy storage device 122, and the second driving device 126 is started and operated to pump liquid-phase fluid and store it in the second driving device 126, including: the second driving device 126 is started and operated to pump liquid-phase fluid from the energy storage device 122 and store it in the second driving device 126. Alternatively, as an alternative embodiment, the second driving device 126 is connected between the liquid-phase fluid container and the energy storage device 122, and the second driving device 126 is started and operated to pump liquid-phase fluid and store it in the second driving device 126, including: the second driving device 126 is started and operated to pump liquid-phase fluid from the liquid-phase fluid container and store it in the second driving device 126.

[0317] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0318] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0319] This embodiment further provides a sample analysis system 10, which includes:

[0320] The sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0321] a first analyzer, which is the aforementioned liquid chromatography device, and is used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0322] a second analyzer, the second analyzer being configured to draw a sample from the sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0323] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0324] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0325] As an embodiment, the second analyzer is a blood cell analyzer 200 , which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0326] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0327] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in Embodiments 1 to 6 and will not be described in detail here.

[0328] Embodiment 8:

[0329] The sample analysis system 10, liquid chromatography equipment, and control method of the liquid chromatography equipment provided in this embodiment differ from those of the first embodiment mainly in that this embodiment does not limit the timing control of the pressure building process, but only requires that the liquid fluid supply component 120 has an energy storage device 122 and a lock-and-release device 123.

[0330] Specifically, the liquid chromatography apparatus provided in this embodiment includes a sample supply assembly 110, a liquid-phase fluid supply assembly 120, a reversing valve 130, a test solution preparation channel 140, a chromatographic column 150, and a detector 160. The chromatographic column 150 is connected between the reversing valve 130 and the detector 160. The reversing valve 130 has a switchable first and second communication states: in the first communication state, the reversing valve 130 connects the sample supply assembly 110 with the test solution preparation channel 140 and the liquid-phase fluid supply assembly 120 with the chromatographic column 150; in the second communication state, the reversing valve 130 connects the liquid-phase fluid supply assembly 120, the test solution preparation channel 140, and the chromatographic column 150. The sample supply assembly 110 is used to supply a test solution composed of at least a sample to the test solution preparation channel 140 via the reversing valve 130. The liquid-phase fluid supply assembly 120 is used to drive the test solution in the test solution preparation channel 140 to the chromatographic column 150 using a liquid-phase fluid, and to drive the liquid-phase fluid to flow sequentially through the reversing valve 130 and the chromatographic column 150. The chromatographic column 150 is used to adsorb the test solution and to supply the liquid-phase fluid to elute the test solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatographic column 150.

[0331] As an embodiment, the liquid-phase fluid supply component 120 includes a first driving device 121, an energy storage device 122 and a lock-and-release device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the reversing valve 130 and the chromatographic column 150. The energy storage device 122 is arranged between the first driving device 121 and the reversing valve 130. The energy storage device 122 includes a shell 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially arranged in the shell 1221 and is separated in the shell 1221 to form a liquid cavity 1223 for liquid-phase fluid to flow through. The potential energy storage and release component 1222 is at least partially able to move relative to the shell 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy.

[0332] As an embodiment, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing it from moving relative to the shell 1221, so as to prevent the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release component 1222 can move relative to the shell 1221 through the pressure of the fluid to store potential energy, and, when the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the shell 1221, so as to allow the potential energy storage and release component 1222 to release the stored potential energy.

[0333] As an embodiment, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 by abutting against the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 by disengaging from the potential energy storage and release component 1222 to release the potential energy storage and release component 1222.

[0334] As an embodiment, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 in a non-liquid locking manner to lock the potential energy storage and release component 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 in a non-liquid conduction manner to release the potential energy storage and release component 1222.

[0335] As an embodiment, the liquid chromatography equipment is a liquid chromatography analyzer 100, the detector 160 is an ultraviolet detector 160 or a fluorescence detector 160, and the sample supply assembly 110 includes a sampling component 111, a first reaction container 112 and a sample infusion path 113. The sampling component 111 is used to draw the sample from the sample container and distribute it to the first reaction container 112. The sample infusion path 113 is used to distribute the hemolysis treatment liquid to the first reaction container 112 and to transport the test liquid made of at least the sample and the hemolysis treatment liquid in the first reaction container 112 to the test liquid preparation channel 140 through the reversing valve 130.

[0336] Alternatively, as another embodiment, the liquid chromatography device is a liquid chromatography and mass spectrometry analyzer 101, the detector 160 is a mass spectrometry detector 160, and the liquid chromatography device also includes a pretreatment device 1011. The pretreatment device 1011 is used to pre-treat the sample from the sample container using at least one of a magnetic separation method, a solid phase extraction method, a liquid-liquid extraction method, and a protein precipitation method to obtain a test solution. The sample supply component 110 is used to transfer at least part of the test solution obtained by the pretreatment device 1011 to the test solution preparation channel 140.

[0337] This embodiment further provides a sample analysis system 10, which includes:

[0338] The sample input device 400 is at least used for receiving a sample container loaded with a sample to achieve sample loading;

[0339] a first analyzer, which is the aforementioned liquid chromatography device, and is used to draw a sample from a sample container and perform chromatographic analysis on at least a portion of the drawn sample;

[0340] a second analyzer, the second analyzer being configured to draw a sample from the sample container and analyze at least a portion of the drawn sample, wherein the second analyzer performs a different measurement on the sample than the measurement performed on the sample by the first analyzer;

[0341] The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography device, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the cell analyzer. The first transfer track 310 and the second transfer track 320 are integrally formed or interconnected.

[0342] The control component 500 is configured to: control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration according to the type of the test item of the sample in the sample container.

[0343] As an embodiment, the second analyzer is a blood cell analyzer 200 , which is used at least to draw a sample from a sample container and perform blood cell analysis on at least a portion of the drawn sample.

[0344] As an embodiment, the sample analysis system 10 further includes an information acquisition device 600, which is used to acquire information representing the type of the item to be tested of the sample in the sample container; the control component 500 is configured to: determine the type of the item to be tested of the sample in the sample container based on the information representing the type of the item to be tested of the sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration based on the type of the item to be tested of the sample in the sample container.

[0345] In addition to the above, other parts of the sample analysis system 10, the liquid chromatography device, and the control method of the liquid chromatography device provided in this embodiment can be referred to in Embodiments 1 to 7 and will not be described in detail here.

[0346] The above description is only a preferred embodiment of the present application and does not limit the patent scope of the present application. All equivalent structural transformations made by using the contents of the present application description and drawings under the inventive concept of the present application, or direct / indirect application in other related technical fields are included in the patent protection scope of the present application.

Claims

1. A sample analysis system, characterized in that: Comprising: A sample input device, which is at least used for placing a sample container loaded with a blood sample to achieve sample loading of the blood sample; A liquid chromatography analyzer, which is used to aspirate a blood sample from the sample container and perform chromatographic analysis on at least a part of the aspirated blood sample; A blood cell analyzer, which is used to aspirate a blood sample from the sample container and perform blood cell analysis on at least a part of the aspirated blood sample; A sample transfer device, which includes a first transfer track and a second transfer track. The first transfer track is used to transfer the sample container from the sample input device to the liquid chromatography analyzer, and the second transfer track is used to transfer the sample container from the sample input device to the blood cell analyzer. The first transfer track and the second transfer track are integrally formed or connected to each other; An information acquisition device, which is used to acquire information characterizing the type of test item of the blood sample in the sample container; A control component, which is configured to: determine the type of test item of the blood sample in the sample container according to the information characterizing the type of test item of the blood sample in the sample container fed back by the information acquisition device; and control the sample transfer device to transfer the sample container to the liquid chromatography analyzer and / or the blood cell analyzer for sample aspiration according to the type of test item of the blood sample in the sample container; Wherein, the liquid chromatography analyzer includes a sample supply component, a liquid phase fluid supply component, a switching valve, a test solution preparation channel, a chromatographic column and a detector. The chromatographic column is connected between the switching valve and the detector. The switching valve has a switchable first connection state and a second connection state: in the first connection state, the switching valve connects the sample supply component and the test solution preparation channel and connects the liquid phase fluid supply component and the chromatographic column; in the second connection state, the switching valve connects the liquid phase fluid supply component, the test solution preparation channel and the chromatographic column; The sample supply component is used to aspirate a blood sample from the sample container and supply, through the switching valve, a test solution made from at least a part of the aspirated blood sample to the test solution preparation channel; The liquid phase fluid supply component is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve and the chromatographic column in sequence; The chromatographic column is used to adsorb the test solution and is used to allow the liquid phase fluid to elute the test solution to form a test solution to be measured; The detector is used to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a locking and releasing device. The first driving device is used to drive the liquid-phase fluid to flow toward the switching valve and the chromatographic column. The energy storage device is arranged between the first driving device and the switching valve. The energy storage device includes a housing and a potential energy storage and release assembly. At least part of the potential energy storage and release assembly is arranged inside the housing and forms a liquid chamber for the liquid-phase fluid to flow through inside the housing. At least part of the potential energy storage and release assembly can move relative to the housing to change the size of the liquid chamber and store potential energy or release the stored potential energy; The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release assembly to lock the potential energy storage and release assembly, thereby preventing the potential energy storage and release assembly from moving relative to the housing and preventing the potential energy storage and release assembly from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing under the pressure of the liquid-phase fluid to store potential energy, and when the locking and releasing device removes the force applied to the potential energy storage and release assembly, the potential energy storage and release assembly is released, thereby allowing the potential energy storage and release assembly to move relative to the housing to allow the potential energy storage and release assembly to release the stored potential energy; The control assembly is further configured to: during the process of performing a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release assembly to move relative to the housing under the pressure of the liquid-phase fluid to store potential energy; within a first preset time period after completing the chromatographic analysis project of a blood sample, if no information about other blood samples that need to perform the chromatographic analysis project is obtained, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release assembly from moving relative to the housing and thus prevent the potential energy storage and release assembly from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device switches to the locked state, if information about a blood sample that needs to perform the chromatographic analysis project is obtained, control the locking and releasing device to switch from the locked state to the released state, so that the potential energy storage and release assembly can move relative to the housing to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve and the chromatographic column.

2. The sample analysis system according to claim 1, characterized in that: The potential energy stored and released by the potential energy storage and release assembly is elastic potential energy; or, The potential energy stored and released by the potential energy storage and release assembly is gravitational potential energy; or, The potential energy stored and released by the potential energy storage and release assembly is gas internal energy.

3. The sample analysis system according to claim 1, wherein: The locking and releasing device applies the force to the potential energy storage and release assembly to lock the potential energy storage and release assembly by abutting against the potential energy storage and release assembly, and the locking and releasing device removes the force applied to the potential energy storage and release assembly to release the potential energy storage and release assembly by disengaging from the potential energy storage and release assembly.

4. The sample analysis system according to claim 1, characterized in that: The locking and releasing device applies the force to the potential energy storage and release component in a non-liquid locking manner to lock the potential energy storage and release component, and the locking and releasing device removes the force applied to the potential energy storage and release component in a non-liquid conduction manner to release the potential energy storage and release component.

5. The sample analysis system according to claim 1, characterized in that: The potential energy storage and release component has a locking portion extending outside the housing, and the locking and releasing device applies the force to the potential energy storage and release component by limiting the locking portion, so as to lock the potential energy storage and release component; The locking and releasing device removes the force applied to the potential energy storage and release component by releasing the locking portion, so as to release the potential energy storage and release component.

6. The sample analysis system according to claim 1, wherein: The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component; When the lock-and-release device is in the locked state, the locking component is in a locked position to lock the potential energy storage-release component, and in the locked position, the locking component abuts against the potential energy storage-release component; Preferably, the transmission component has a self-locking capability, and when the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by the locking force generated by the self-locking of the transmission component to lock the potential energy storage and release component.

7. The sample analysis system according to claim 6, wherein: The power component is a motor; When the locking and releasing device is in the locked state, the motor is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to lock the potential energy storage and release assembly; When the locking and releasing device is in the released state, the motor is in a stopped state, the locking component is in an unlocked position to release the potential energy storage and release component, and in the unlocked position, the locking component is separated from the potential energy storage and release component; During the process of the lock-release device switching from the locked state to the released state, the motor is in a running state to drive the locking component to move from the locked position to the unlocked position through the transmission component; During the process of the lock-and-release device switching from the released state to the locked state, the motor is in a running state to drive the locking component to move from the unlocked position to the locked position through the transmission component.

8. The sample analysis system according to claim 7, characterized in that: The potential energy storage and release component has a locking portion extending outside the shell, and the locking portion has a locking end surface facing the liquid cavity; The locking component is formed with a locking portion, and the locking portion is used to move between the locking position and the unlocking position under the drive of the power component and the transmission component; Controlling the lock-release device to switch to the locked state to prevent the energy storage device from releasing the stored potential energy includes: controlling the power component to start and operate to drive the transmission component to drive the locking portion to move from the unlocked position to the locked position, so that the locking portion abuts against the clamping end face. After the locking portion moves to the locked position, control the power component to stop operating, so that the locking portion is held at the locked position under the action of the locking force generated by the self-locking of the transmission component; Controlling the lock-release device to switch from the locked state to the released state to enable the energy storage device to release the stored potential energy includes: controlling the power component to start and operate to drive the transmission component to drive the locking portion to move from the locked position to the unlocked position, so that the locking portion disengages from the clamping end face, thereby enabling the potential energy storage and release assembly to release the stored potential energy and move towards the liquid chamber to drive the liquid-phase fluid in the liquid chamber to flow out of the liquid chamber.

9. The sample analysis system according to claim 8, wherein: The lock-release device further includes a detection component, and the control component is further configured to: during the process of the power component driving the transmission component to drive the locking portion to move from the unlocked position to the locked position, obtain the feedback information of the detection component, and when it is determined according to the feedback information of the detection component that the locking portion moves to the locked position, control the power component to stop operating; Preferably, the detection component is a reflective photoelectric sensor or an opposed photoelectric sensor or a proximity switch.

10. The sample analysis system according to claim 8, wherein: The potential energy stored and released by the potential energy storage and release assembly is elastic potential energy; The potential energy storage and release assembly includes a diaphragm, an elastic element, and a guide rod. The diaphragm is disposed in the housing and cooperates with the inner wall of the housing to form the liquid chamber. One end of the guide rod is connected to the diaphragm, and the other end of the guide rod extends outside the housing and forms the clamping portion. The elastic element is located in the housing and sleeved on the guide rod; The lock-release device being in the locked state includes: the locking portion abutting against the clamping portion to lock the clamping portion, thereby enabling the elastic element to store the elastic potential energy; The lock-release device being in the released state includes: the locking portion disengaging from the clamping portion to release the clamping portion, thereby allowing the elastic element to release the elastic potential energy.

11. The sample analysis system according to claim 10, characterized in that: The stiffness of the elastic element is greater than or equal to 500 N / mm and less than or equal to 30,000 N / mm; and / or, The elastic element includes at least a pair of disc spring groups.

12. The sample analysis system according to any one of claims 6 to 11, characterized in that: The transmission component includes a screw drive pair, and the lead angle of the screw drive pair is less than the equivalent friction angle; and / or, The transmission component includes a screw drive pair, and the screw drive pair is a trapezoidal screw drive pair.

13. The sample analysis system according to any one of claims 1 to 11, characterized in that: If information that a blood sample needs to perform a chromatographic analysis item is obtained, then controlling the lock-release device to switch from the locked state to the released state includes: first controlling the first driving device to start and operate, and then controlling the lock-release device to switch from the locked state to the released state.

14. The sample analysis system according to claim 13, characterized in that: Controlling the first driving device to start and operate first, and then controlling the locking and releasing device to switch from the locked state to the released state includes: first controlling the first driving device to start and keep operating for a second preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatographic column is greater than zero and less than the target pressure value or less than the lower limit of the target pressure range, and then controlling the locking and releasing device to switch from the locked state to the released state; The control component is further configured to: during the process of performing a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column; before performing the first chromatographic analysis project after the liquid chromatograph is powered on, first control the first driving device to start and keep operating for a third preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatographic column reaches the target pressure value or the target pressure range; The control component is further configured to: after controlling the locking and releasing device to switch from the locked state to the released state, first control the first driving device to continue to keep operating for a fourth preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatographic column substantially reaches the target pressure value or the target pressure range, and then control the switching valve to switch to the second communication state, so that the liquid-phase fluid supply component drives the test solution in the test solution preparation channel to be delivered to the chromatographic column through the liquid-phase fluid; Wherein, the sum of the second preset duration and the fourth preset duration is less than the third preset duration; Preferably, the sum of the second preset duration and the fourth preset duration is less than half of the third preset duration.

15. The sample analysis system according to claim 14, characterized in that: The housing is formed with a liquid inlet for the liquid-phase fluid to flow into the liquid chamber and a liquid outlet for the liquid-phase fluid to flow out of the liquid chamber; After controlling the locking and releasing device to switch to the locked state and controlling the first driving device to stop driving the liquid-phase fluid to flow, and before controlling the first driving device to start and controlling the locking and releasing device to switch from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet is a first pressure value, and the first pressure value is less than the target pressure value or less than the lower limit of the target pressure range; After the first driving device starts and keeps operating for the second preset duration and during the process of the locking and releasing device switching from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet is a second pressure value, and the second pressure value is greater than the target pressure value or greater than the upper limit of the target pressure range; After the locking and releasing device switches from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet is a third pressure value, and the third pressure value is substantially equal to the target pressure value or falls within the target pressure range.

16. The sample analysis system according to claim 14, wherein: After controlling the locking and releasing device to switch to the locked state and controlling the first driving device to stop driving the liquid-phase fluid from flowing, and before controlling the first driving device to start and controlling the locking and releasing device to switch from the locked state to the released state, the volume of the liquid chamber is a first volume; after the first driving device starts and operates for the second preset duration and before the locking and releasing device switches from the locked state to the released state, the volume of the liquid chamber is a second volume; after the locking and releasing device switches from the locked state to the released state, the volume of the liquid chamber is a third volume; wherein, the second volume is greater than the first volume and greater than the third volume; and / or, After controlling the locking and releasing device to switch to the locked state and controlling the first driving device to stop driving the liquid-phase fluid from flowing, and before controlling the first driving device to start operating and controlling the locking and releasing device to switch from the locked state to the released state, the potential energy stored in the energy storage device is a first potential energy; after the first driving device starts and operates for the second preset duration and before the locking and releasing device switches from the locked state to the released state, the potential energy stored in the energy storage device is a second potential energy; after the locking and releasing device switches from the locked state to the released state, the potential energy stored in the energy storage device is a third potential energy; wherein, the second potential energy is greater than the first potential energy and greater than the third potential energy.

17. The sample analysis system according to any one of claims 1 to 11, characterized in that: The energy storage device has an inlet for the liquid-phase fluid to flow in and an outlet for the liquid-phase fluid to flow out. After controlling the locking and releasing device to switch to the locked state and controlling the first driving device to stop driving the liquid-phase fluid from flowing, and before controlling the first driving device to start and controlling the locking and releasing device to switch from the locked state to the released state, the pressure value of the liquid-phase fluid at the outlet is a first pressure value. The first pressure value is approximately zero.

18. The sample analysis system according to any one of claims 1 to 11, characterized in that: Within the first preset duration after completing the chromatographic analysis project of a blood sample, if there is no situation where other blood samples need to perform the chromatographic analysis project, controlling the locking and releasing device to switch to the locked state and controlling the first driving device to stop driving the liquid-phase fluid from flowing includes: Within the first preset duration after completing the chromatographic analysis project of a blood sample, if there is no information that other blood samples need to perform the chromatographic analysis project, first control the locking and releasing device to switch to the locked state, and then control the first driving device to stop driving the liquid-phase fluid from flowing; or, Within the first preset duration after completing the chromatographic analysis project of a blood sample, if there is no information that other blood samples need to perform the chromatographic analysis project, control the locking and releasing device to switch to the locked state and at the same time control the first driving device to stop driving the liquid-phase fluid from flowing; or, Within the first preset duration after completing a chromatographic analysis project on a blood sample, if no information indicating that there is another blood sample requiring a chromatographic analysis project is obtained, first control the first driving device to stop driving the liquid-phase fluid to flow, and then control the locking and releasing device to switch to the locked state.

19. The sample analysis system according to claim 1, wherein: The control component is further configured to: Control the sample supply component to complete the following test solution preparation actions within the fifth preset duration: suck a blood sample from the sample container and distribute it to the first reaction container, and transport the test solution made of at least the blood sample and a hemolytic agent in the first reaction container to the sample preparation channel through the switching valve; When the locking and releasing device is in the locked state, if information indicating that there is a blood sample requiring a chromatographic analysis project is obtained, control the liquid-phase fluid supply component to complete the following pressure building actions within the sixth preset duration: control the first driving device to start and operate, and control the locking and releasing device to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply component driving the liquid-phase fluid to flow to the chromatographic column reaches the target pressure value or the target pressure range within the sixth preset duration; During the process of performing the chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column; Wherein, the sixth preset duration is less than the fifth preset duration.

20. The sample analysis system according to any one of claims 1 to 11 or claim 19, characterized in that: The control component is further configured to: When the locking and releasing device is in the locked state and the switching valve is in the first connection state, if information indicating that there is a blood sample requiring a chromatographic analysis project is obtained, control the sample supply component to perform the following test solution preparation actions: suck a blood sample from the sample container and distribute it to the first reaction container, and transport the test solution made of at least the blood sample and a hemolytic agent in the first reaction container to the sample preparation channel through the switching valve; During the process of the sample supply component performing the test solution preparation actions, control the first driving device to start and operate, control the locking and releasing device to switch from the locked state to the released state, and control the switching valve to remain in the first connection state; After the sample supply component completes the test solution preparation actions, control the switching valve to switch from the first connection state to the second connection state, so that the liquid-phase fluid supply component drives the test solution in the sample preparation channel to be transported to the chromatographic column through the liquid-phase fluid.

21. The sample analysis system according to any one of claims 1 to 11 or claim 19, characterized in that: The control component is further configured to: in the case where the locking and releasing device continuously remains in the locked state for the seventh preset duration, if no information indicating that there is a blood sample requiring a chromatographic analysis project is obtained, control the locking and releasing device to switch from the locked state to the released state, so that the energy storage device releases the stored potential energy; The seventh preset duration is greater than the duration required to complete one chromatographic analysis project and greater than the first preset duration.

22. The sample analysis system according to claim 21, characterized in that: The seventh preset duration is greater than or equal to the duration required to complete 10 of the chromatographic analysis items; and / or, The seventh preset duration is greater than or equal to 5 minutes and less than or equal to 2 hours.

23. A sample analysis system, characterized in that: Comprising: A sample input device, which is at least used for placing a sample container loaded with a blood sample to achieve the loading of the blood sample; A liquid chromatography analyzer, which is used for sucking a blood sample from the sample container and performing chromatographic analysis on at least part of the sucked blood sample; A blood cell analyzer, which is used for sucking a blood sample from the sample container and performing blood cell analysis on at least part of the sucked blood sample; A sample transmission device, which includes a first transmission track and a second transmission track. The first transmission track is used for transmitting the sample container from the sample input device to the liquid chromatography analyzer, and the second transmission track is used for transmitting the sample container from the sample input device to the blood cell analyzer. The first transmission track and the second transmission track are integrally formed or connected to each other; An information acquisition device, which is used for acquiring information characterizing the type of the test item of the blood sample in the sample container; A control component, which is configured to: determine the type of the test item of the blood sample in the sample container according to the information characterizing the type of the test item of the blood sample in the sample container fed back by the information acquisition device; and control the sample transmission device to transmit the sample container to the liquid chromatography analyzer and / or the blood cell analyzer for sucking the sample according to the type of the test item of the blood sample in the sample container; Wherein, the liquid chromatography analyzer includes a sample supply component, a liquid phase fluid supply component, a reversing valve, a test solution preparation channel, a chromatographic column and a detector. The reversing valve has a switchable first communication state and a second communication state: in the first communication state, the reversing valve connects the sample supply component and the test solution preparation channel and connects the liquid phase fluid supply component and the chromatographic column; in the second communication state, the reversing valve connects the liquid phase fluid supply component, the test solution preparation channel and the chromatographic column. The chromatographic column is connected between the reversing valve and the detector; The sample supply component is used for sucking a blood sample from the sample container and supplying, through the reversing valve, a test solution made of at least part of the sucked blood sample to the test solution preparation channel; The liquid phase fluid supply component is used for driving the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid phase fluid, and for driving the liquid phase fluid to flow through the reversing valve and the chromatographic column in sequence; The chromatographic column is used for adsorbing the test solution and for allowing the liquid phase fluid to elute the test solution to form a test solution to be measured; The detector is used for performing chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a locking and releasing device. The first driving device is used to drive the liquid-phase fluid to flow toward the switching valve and the chromatographic column. The energy storage device is disposed between the first driving device and the switching valve. The energy storage device includes a housing and a potential energy storage and release assembly. At least part of the potential energy storage and release assembly is disposed inside the housing and forms a liquid chamber for the liquid-phase fluid to flow through inside the housing. At least part of the potential energy storage and release assembly can move relative to the housing to change the size of the liquid chamber and store potential energy or release the stored potential energy. The locking and releasing device can switch between a locked state and a released state; The control assembly is further configured to: during the process of performing a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release assembly to move relative to the housing under the pressure action of the liquid-phase fluid to store potential energy; within a first preset time period after completing the chromatographic analysis project of a blood sample, if information indicating that there is no other blood sample requiring a chromatographic analysis project is not obtained, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release assembly from moving relative to the housing, thereby preventing it from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; When the locking and releasing device is in the locked state and the switching valve is in the first communication state, if information indicating that there is a blood sample requiring a chromatographic analysis project is obtained, control the sample supply assembly to perform the following test solution preparation actions: suck a blood sample from a sample container and distribute it to a first reaction container, and transport the test solution made at least of the blood sample and a hemolytic agent in the first reaction container to the sample preparation channel through the switching valve; During the process of the sample supply assembly performing the test solution preparation actions, control the first driving device to start and operate, and control the locking and releasing device to switch from the locked state to the released state, so that the potential energy storage and release assembly moves relative to the housing to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve and the chromatographic column; After the sample supply assembly completes the test solution preparation actions, control the switching valve to switch from the first communication state to the second communication state, so that the liquid-phase fluid supply assembly drives the test solution in the test solution preparation channel to the chromatographic column through the liquid-phase fluid.

24. The sample analysis system according to claim 23, characterized in that: The control assembly is further configured to: control the sample supply assembly to complete the following test solution preparation actions within a fifth preset time period: suck a blood sample from a sample container and distribute it to a first reaction container, and transport the test solution made at least of the blood sample and a hemolytic agent in the first reaction container to the sample preparation channel through the switching valve; When the lock-and-release device is in the locked state, if information indicating that a blood sample needs to undergo a chromatographic analysis project is obtained, the liquid-phase fluid supply assembly is controlled to complete the following pressure-building operation within a sixth preset duration: control the first driving device to start and operate, and control the lock-and-release device to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supplied by the liquid-phase fluid supply assembly flowing to the chromatographic column reaches a target pressure value or a target pressure range within a fifth preset duration; During the process of performing the chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column; The sixth preset duration is less than the fifth preset duration.

25. The sample analysis system according to claim 24, characterized in that: The first controller is further configured to: before the first chromatographic analysis project after the liquid chromatograph is powered on, first control the first driving device to start and operate for a third preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatographic column reaches the target pressure value or the target pressure range; The sixth preset duration is less than the third preset duration.

26. A liquid chromatography device, characterized in that: It includes a sample supply assembly, a liquid-phase fluid supply assembly, a switching valve, a test-solution preparation channel, a chromatographic column, a detector, and a first controller. The chromatographic column is connected between the switching valve and the detector. The switching valve has a switchable first communication state and second communication state: in the first communication state, the switching valve connects the sample supply assembly and the test-solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the switching valve connects the liquid-phase fluid supply assembly, the test-solution preparation channel, and the chromatographic column; The sample supply assembly is used to supply a test solution made at least of a sample to the test-solution preparation channel through the switching valve; The liquid-phase fluid supply assembly is used to drive the test solution in the test-solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the switching valve and the chromatographic column in sequence; The chromatographic column is used to adsorb the test solution and to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured; The detector is used to analyze the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply assembly includes a first driving device and an energy storage device. The first driving device is used to drive the liquid-phase fluid to flow towards the switching valve and the chromatographic column. The energy storage device is arranged between the first driving device and the switching valve. The energy storage device is used to store potential energy or release the stored potential energy; The first controller is configured to: during the process of performing a chromatographic analysis project on a sample, control the first driving device to drive the liquid-phase fluid to flow to elute the test solution adsorbed on the chromatographic column, and control the energy storage device to store potential energy through the pressure action of the liquid-phase fluid; After completing the chromatographic analysis project of the one sample and when performing the chromatographic analysis project of the next sample, control the energy storage device to release the potential energy stored during the process of performing the chromatographic analysis project of the one sample to assist in driving the liquid-phase fluid to flow towards the switching valve and the chromatographic column.

27. The liquid chromatography device according to claim 26, wherein: The liquid-phase fluid supply assembly further includes a locking and releasing device that can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the energy storage device to lock the energy storage device, thereby preventing the energy storage device from releasing the stored potential energy; In the released state, the energy storage device can store potential energy under the pressure of the liquid-phase fluid, and when the force applied by the locking and releasing device to the energy storage device is removed, the energy storage device is released, thereby allowing the energy storage device to release the stored potential energy; The control of the energy storage device to store potential energy under the pressure of the liquid-phase fluid includes: controlling the locking and releasing device to be in the released state to allow the energy storage device to store potential energy under the pressure of the liquid-phase fluid; The control of the energy storage device to release the potential energy stored during the process of performing the chromatographic analysis project of the one sample after completing the chromatographic analysis project of the one sample and when performing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of the one sample, controlling the locking and releasing device to switch from the released state to the locked state to prevent the energy storage device from releasing the stored potential energy, and controlling the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device switches to the locked state, when performing the chromatographic analysis project of the next sample, controlling the locking and releasing device to switch from the locked state to the released state so that the energy storage device releases the potential energy stored during the process of performing the chromatographic analysis project of the one sample.

28. The liquid chromatography device according to claim 27, wherein: The control of the locking and releasing device to switch from the released state to the locked state to prevent the energy storage device from releasing the stored potential energy and the control of the first driving device to stop driving the liquid-phase fluid to flow after completing the chromatographic analysis project of the one sample includes: within a first preset time period after completing the chromatographic analysis project of the one sample, if information that there are other samples that need to perform chromatographic analysis projects is not obtained, then control the locking and releasing device to switch from the released state to the locked state to prevent the energy storage device from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; After the locking and releasing device is switched to the locked state, when performing the chromatographic analysis item of the next sample, control the locking and releasing device to switch from the locked state to the released state, so that the energy storage device releases the potential energy stored during the process of performing the chromatographic analysis item of one sample, including: after the locking and releasing device is switched to the locked state, if information that a sample needs to perform a chromatographic analysis item is obtained, control the locking and releasing device to switch from the locked state to the released state, so that the energy storage device releases the potential energy stored during the process of performing the chromatographic analysis item of one sample, to assist in driving the liquid-phase fluid to flow towards the switching valve and the chromatographic column.

29. The liquid chromatography device according to any one of claims 26 to 28, characterized in that: The liquid chromatography device is a liquid chromatography analyzer, the detector is an ultraviolet detector or a fluorescence detector, the sample supply assembly includes a sampling component, a first reaction container and a sample liquid delivery path. The sampling component is used to suck a sample from the sample container and distribute it to the first reaction container. The sample liquid delivery path is used to distribute the hemolysis treatment liquid to the first reaction container and to transport the test solution made of at least the sample and the hemolysis treatment liquid in the first reaction container to the test solution preparation channel through the switching valve. Alternatively, the liquid chromatography device is a liquid chromatography-mass spectrometry combined analyzer, the detector is a mass spectrometry detector, the liquid chromatography device further includes a pre-processor. The pre-processor is used to pre-process the sample from the sample container by at least one of magnetic separation, solid-phase extraction, liquid-liquid extraction, and protein precipitation methods to obtain the test solution. The sample supply assembly is used to transfer at least part of the test solution obtained by the pre-processor to the test solution preparation channel.

30. A liquid chromatography device, characterized in that: It includes a sample supply assembly, a liquid-phase fluid supply assembly, a switching valve, a test solution preparation channel, a chromatographic column, a detector and a first controller. The chromatographic column is connected between the switching valve and the detector. The switching valve has switchable first and second communication states: in the first communication state, the switching valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the switching valve connects the liquid-phase fluid supply assembly, the test solution preparation channel and the chromatographic column. The sample supply assembly is used to supply the test solution made of at least the sample to the test solution preparation channel through the switching valve. The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the switching valve and the chromatographic column in sequence. The chromatographic column is used to adsorb the test solution and to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured. The detector is used to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column. The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a locking and releasing device. The first driving device is used to drive the liquid-phase fluid to flow toward the switching valve and the chromatographic column. The energy storage device is arranged between the first driving device and the switching valve. The energy storage device includes a housing and a potential energy storage and release assembly. At least part of the potential energy storage and release assembly is arranged inside the housing and forms a liquid cavity for the liquid-phase fluid to flow through inside the housing. At least part of the potential energy storage and release assembly can move relative to the housing to change the size of the liquid cavity and store potential energy or release the stored potential energy; The locking and releasing device can be switched between a locked state and a released state: in the locked state, the locking and releasing device abuts against the potential energy storage and release assembly to lock the potential energy storage and release assembly, thereby preventing it from moving relative to the housing and preventing the potential energy storage and release assembly from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing under the pressure of the liquid-phase fluid to store potential energy, and, when the locking and releasing device disengages from the potential energy storage and release assembly, the potential energy storage and release assembly is released, thereby allowing the potential energy storage and release assembly to move relative to the housing to allow the potential energy storage and release assembly to release the stored potential energy; The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release assembly to move relative to the housing under the pressure of the liquid-phase fluid to store potential energy; Within a first preset time period after the execution of a chromatographic analysis project for a sample is completed, if no information about other samples that need to execute chromatographic analysis projects is obtained, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release assembly from moving relative to the housing and thus prevent it from releasing the stored potential energy, and control the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device switches to the locked state, if information about a sample that needs to execute a chromatographic analysis project is obtained, control the locking and releasing device to switch from the locked state to the released state, so that the potential energy storage and release assembly can move relative to the housing to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve and the chromatographic column.

31. The liquid chromatography device according to claim 30, characterized in that: The potential energy storage and release assembly has a clamping portion extending outside the housing. The locking and releasing device locks the potential energy storage and release assembly by abutting and limiting the clamping portion, and the locking and releasing device releases the potential energy storage and release assembly by disengaging to release the clamping portion; and / or, The locking and releasing device includes a power component, a locking component, and a transmission component that is transmission-connected between the power component and the locking component. The transmission component has a self-locking ability. When the locking and releasing device is in the locked state, the power component is in a stopped operating state, and the locking component is in a locked position by the locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release assembly.

32. The liquid chromatography device according to claim 30 or 31, characterized in that: The first controller is further configured to: Control the sample supply assembly to perform the following test solution preparation actions within a fifth preset time period: suck a sample from a sample container and distribute it to a first reaction container, and transport the test solution made at least of the sample and a hemolytic agent in the first reaction container to the sample preparation channel through the switching valve; When the locking and releasing device is in the locked state, if information that a sample needs to perform a chromatographic analysis item is obtained, control the liquid-phase fluid supply assembly to perform the following pressure building actions within a sixth preset time period: control the first driving device to start and operate, and control the locking and releasing device to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply assembly driving the liquid-phase fluid to flow to the chromatographic column reaches a target pressure value or a target pressure range within the fifth preset time period; During the process of performing the chromatographic analysis item, control the first driving device to drive the liquid-phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column; The sixth preset time period is less than the fifth preset time period.

33. A liquid chromatography device, characterized in that: It includes a sample supply assembly, a liquid-phase fluid supply assembly, a switching valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller. The chromatographic column is connected between the switching valve and the detector. The switching valve has a switchable first communication state and a second communication state: in the first communication state, the switching valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the switching valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column; The sample supply assembly is used to supply a test solution made at least of a sample to the test solution preparation channel through the switching valve; The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve and the chromatographic column in sequence; The chromatographic column is used to adsorb the test solution and to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured; The detector is used to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid phase fluid supply assembly comprises a first driving device, an energy storage device and a lock-release device, wherein the first driving device is used to drive the liquid phase fluid to flow toward the reversing valve and the chromatographic column, the energy storage device is arranged between the first driving device and the reversing valve, the energy storage device comprises a housing and a potential energy storage and release assembly, the potential energy storage and release assembly is at least partially arranged in the housing and is separated in the housing to form a liquid cavity for the liquid phase fluid to flow through, and the potential energy storage and release assembly is at least partially capable of moving relative to the housing to change the size of the liquid cavity and store potential energy or release the stored potential energy; The lock-release device can switch between a locked state and a released state: in the locked state, the lock-release device locks the potential energy storage-release component by non-liquid path locking, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage-release component from releasing the stored potential energy; in the released state, the potential energy storage-release component can move relative to the shell by the pressure of the liquid phase fluid to store potential energy, and the lock-release device releases the potential energy storage-release component by non-liquid path conduction, thereby allowing the potential energy storage-release component to release the stored potential energy; The first controller is configured to: during the execution of the chromatographic analysis project, control the first driving device to drive the liquid phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column, and control the lock-release device to be in the release state so as to allow the potential energy storage and release component to move relative to the shell under the pressure of the liquid phase fluid to store potential energy; Within a first preset time period after completing a chromatographic analysis project for a sample, if no information is obtained that there are other samples that need to perform chromatographic analysis projects, the lock-and-release device is controlled to switch from the released state to the locked state to prevent the potential energy storage-release component from moving relative to the shell to prevent it from releasing the stored potential energy, and the first driving device is controlled to stop driving the liquid-phase fluid to flow; after the lock-and-release device is switched to the locked state, if information is obtained that there are samples that need to perform chromatographic analysis projects, the lock-and-release device is controlled to switch from the locked state to the released state, so that the potential energy storage-release component can move relative to the shell to release the stored potential energy, so as to assist in driving the liquid-phase fluid to flow toward the reversing valve and the chromatographic column.

34. The liquid chromatography device according to claim 33, characterized in that: The potential energy storage and release component has a locking portion extending outside the housing, the locking and releasing device locks the potential energy storage and release component by abutting and limiting the locking portion, and the locking and releasing device releases the potential energy storage and release component by disengaging to release the locking portion; and / or, The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component, wherein the transmission component has a self-locking capability. When the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release component.

35. A liquid chromatography device, characterized in that: It includes a sample supply component, a liquid-phase fluid supply component, a switching valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller. The chromatographic column is connected between the switching valve and the detector. The switching valve has a switchable first communication state and second communication state: in the first communication state, the switching valve connects the sample supply component and the test solution preparation channel and connects the liquid-phase fluid supply component and the chromatographic column; in the second communication state, the switching valve connects the liquid-phase fluid supply component, the test solution preparation channel, and the chromatographic column; The sample supply component is configured to supply a test solution made at least of a sample to the test solution preparation channel through the switching valve; The liquid-phase fluid supply component is configured to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the switching valve and the chromatographic column in sequence; The chromatographic column is configured to adsorb the test solution and to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured; The detector is configured to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply component includes a first driving device, an energy storage device, and a locking and releasing device. The first driving device is configured to drive the liquid-phase fluid to flow towards the switching valve and the chromatographic column. The energy storage device is disposed between the first driving device and the switching valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially disposed within the housing and divides the interior of the housing to form a liquid chamber for the liquid-phase fluid to flow through. The housing is formed with an inlet for the liquid-phase fluid to flow into the liquid chamber and an outlet for the liquid-phase fluid to flow out of the liquid chamber. At least a part of the potential energy storage and release assembly is capable of moving relative to the housing to change the size of the liquid chamber and store potential energy or release the stored potential energy; The locking and releasing device is capable of switching between a locked state and a released state: in the locked state, the locking and releasing device prevents the potential energy storage and release assembly from releasing the stored potential energy; in the released state, the locking and releasing device allows the potential energy storage and release assembly to store potential energy and release the stored potential energy; The first controller is configured to: during the execution of a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow at a target pressure value or a pressure value within a target pressure range to elute the test solution adsorbed on the chromatographic column, and control the locking and releasing device to be in the released state to allow the potential energy storage and release assembly to store potential energy by moving relative to the housing under the pressure action of the liquid-phase fluid; Within the first preset duration after completing the chromatographic analysis project of a sample, if there is no situation where other samples need to perform the chromatographic analysis project, then control the locking and releasing device to switch from the release state to the locking state, so as to prevent the potential energy storage and release component from moving relative to the housing, thereby preventing the release of the stored potential energy. Control the first driving device to stop driving the liquid-phase fluid to flow, so that the pressure of the liquid-phase fluid at the liquid outlet is maintained at a first pressure value. When the locking and releasing device is in the locked state, if information that a sample needs to perform the chromatographic analysis project is obtained, then control the locking and releasing device to switch from the locked state to the release state, so that the potential energy storage and release component can move relative to the housing to release the stored potential energy, so as to assist in driving the liquid-phase fluid to flow towards the reversing valve and the chromatographic column; Wherein, the first pressure value is approximately equal to the target pressure value or within the target pressure range, or the first pressure value is approximately equal to zero.

36. The liquid chromatography device according to claim 35, wherein: If information that a sample needs to perform the chromatographic analysis project is obtained, then controlling the locking and releasing device to switch from the locked state to the release state includes: first controlling the first driving device to start and keep running for a second preset duration, so that the pressure of the fluid flowing towards the chromatographic column reaches the target pressure value or the target pressure range, and then controlling the locking and releasing device to switch from the locked state to the release state; After the first driving device starts running and reaches the second preset duration and during the process of the locking and releasing device switching from the locked state to the release state, the pressure value of the liquid-phase fluid at the liquid outlet is a second pressure value, and the second pressure value is greater than the target pressure value or greater than the upper limit value of the target pressure range; After the locking and releasing device switches from the locked state to the release state, the pressure value of the liquid-phase fluid at the liquid outlet is a third pressure value, and the third pressure value is approximately equal to the target pressure value or falls within the target pressure range.

37. The liquid chromatography device according to claim 36, characterized in that: The first controller is further configured to: after controlling the locking and releasing device to switch from the locked state to the release state, first control the first driving device to continue to keep running for a fourth preset duration, so that the pressure of the liquid-phase fluid flowing towards the chromatographic column approximately reaches the target pressure value or the target pressure range, and then control the reversing valve to switch to the second communication state, so that the liquid-phase fluid supply component drives the test solution in the test solution preparation channel to the chromatographic column through the liquid-phase fluid; Wherein, the sum of the second preset duration and the fourth preset duration is less than the third preset duration.

38. The liquid chromatography device according to any one of claims 35 to 37, characterized in that: The locking and releasing device includes a two-way valve connected between the energy storage device and the reversing valve; The locking and releasing device is in the locked state: the two-way valve is in the closed state; The locking and releasing device is in the release state: the two-way valve is in the open state; The first pressure value is approximately equal to the target pressure value or within the target pressure range; Preferably, the first pressure value is greater than or equal to 2 MPa and less than or equal to 10 MPa; More preferably, the first pressure value is greater than or equal to 4 MPa and less than or equal to 6 MPa.

39. A liquid chromatography device, characterized in that: It includes a sample supply assembly, a liquid-phase fluid supply assembly, a reversing valve, a test solution preparation channel, a chromatographic column, a detector, and a first controller. The reversing valve has a switchable first connection state and second connection state: in the first connection state, the reversing valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second connection state, the reversing valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column. The chromatographic column is connected between the reversing valve and the detector; The sample supply assembly is used to supply a test solution made at least of a sample to the test solution preparation channel through the reversing valve; The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and to drive the liquid-phase fluid to flow through the reversing valve and the chromatographic column in sequence; The chromatographic column is used to adsorb the test solution and to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured; The detector is used to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply assembly includes a first driving device, a second driving device, and an energy storage device. The first driving device is connected between a liquid-phase fluid container and the energy storage device. The first driving device is used to drive the liquid-phase fluid to flow towards the reversing valve and the chromatographic column. The energy storage device is used to store potential energy when the first driving device drives the liquid-phase fluid to flow. The second driving device is connected to the liquid-phase fluid container and / or the energy storage device. The second driving device is used to suck and store the liquid-phase fluid and to use the stored liquid-phase fluid to assist in driving the liquid-phase fluid to flow towards the reversing valve and the chromatographic column; The first controller is configured to: during the process of performing a chromatographic analysis project, control the first driving device to drive the liquid-phase fluid to flow to elute the test solution adsorbed on the chromatographic column; Within a first preset time period after completing the chromatographic analysis project of a sample, if no information about other samples that need to perform the chromatographic analysis project is obtained, then control the second driving device to start and operate to suck and store the liquid-phase fluid in the second driving device, and control the first driving device to stop driving the liquid-phase fluid to flow; after the second driving device stores the liquid-phase fluid, if information about a sample that needs to perform the chromatographic analysis project is obtained, then control the first driving device to start and operate to drive the liquid-phase fluid to flow towards the reversing valve and the chromatographic column, and control the second driving device to start and operate to assist in driving the liquid-phase fluid to flow towards the reversing valve and the chromatographic column by the stored liquid-phase fluid.

40. The liquid chromatography device according to claim 39, characterized in that: The second driving device is connected to the energy storage device. The second driving device starts and operates to suck the liquid-phase fluid and store it in the second driving device, including: the second driving device starts and operates to suck the liquid-phase fluid from the energy storage device and store it in the second driving device; or, The second driving device is connected between the liquid-phase fluid container and the energy storage device. The second driving device starts and operates to suck the liquid-phase fluid and store it in the second driving device, including: the second driving device starts and operates to suck the liquid-phase fluid from the liquid-phase fluid container and store it in the second driving device.

41. A liquid chromatography device, characterized in that: It includes a sample supply assembly, a liquid-phase fluid supply assembly, a switching valve, a test solution preparation channel, a chromatographic column, and a detector. The chromatographic column is connected between the switching valve and the detector. The switching valve has a switchable first communication state and second communication state: in the first communication state, the switching valve connects the sample supply assembly and the test solution preparation channel and connects the liquid-phase fluid supply assembly and the chromatographic column; in the second communication state, the switching valve connects the liquid-phase fluid supply assembly, the test solution preparation channel, and the chromatographic column; The sample supply assembly is used to supply a test solution made at least of the sample to the test solution preparation channel through the switching valve; The liquid-phase fluid supply assembly is used to drive the test solution in the test solution preparation channel to be transported to the chromatographic column by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve and the chromatographic column in sequence; The chromatographic column is used to adsorb the test solution and is used to allow the liquid-phase fluid to elute the test solution to form a test solution to be measured; The detector is used to perform chromatographic analysis on the test solution to be measured flowing out of the chromatographic column; The liquid-phase fluid supply assembly includes a first driving device, an energy storage device, and a locking and releasing device. The first driving device is used to drive the liquid-phase fluid to flow towards the switching valve and the chromatographic column. The energy storage device is arranged between the first driving device and the switching valve. The energy storage device includes a housing and a potential energy storage and release assembly. The potential energy storage and release assembly is at least partially arranged in the housing and forms a liquid cavity for the liquid-phase fluid to flow through in the housing by partitioning. At least part of the potential energy storage and release assembly can move relative to the housing to change the size of the liquid cavity and store potential energy or release the stored potential energy; The locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release assembly to lock the potential energy storage and release assembly, thereby preventing it from moving relative to the housing and preventing the potential energy storage and release assembly from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing under the pressure of the fluid to store potential energy, and, when the locking and releasing device removes the force applied to the potential energy storage and release assembly, the potential energy storage and release assembly is released, thereby allowing the potential energy storage and release assembly to move relative to the housing and allowing the potential energy storage and release assembly to release the stored potential energy.

42. The liquid chromatography device according to claim 41, characterized in that: The locking and releasing device applies the force to the potential energy storage and release assembly to lock the potential energy storage and release assembly by abutting against the potential energy storage and release assembly, and the locking and releasing device removes the force applied to the potential energy storage and release assembly to release the potential energy storage and release assembly by disengaging from the potential energy storage and release assembly; and / or, The locking and releasing device applies the force to the potential energy storage and release assembly to lock the potential energy storage and release assembly by a non-liquid path locking method, and the locking and releasing device removes the force applied to the potential energy storage and release assembly to release the potential energy storage and release assembly by a non-liquid path conducting method.

43. A sample analysis system, characterized in that: Comprising: A sample input device for at least allowing a sample container loaded with a sample to be placed therein to achieve sample loading; A first analyzer, which is a liquid chromatography device according to any one of claims 26 to 42, and the liquid chromatography device is used to aspirate a sample from the sample container and perform chromatographic analysis on at least a part of the aspirated sample; A second analyzer for aspirating a sample from the sample container and analyzing at least a part of the aspirated sample, and the measurement items performed by the second analyzer on the sample are different from the measurement items performed by the first analyzer on the sample; A sample transfer device, which includes a first transfer track and a second transfer track. The first transfer track is used to transfer the sample container from the sample input device to the liquid chromatography device, and the second transfer track is used to transfer the sample container from the sample input device to the cell analyzer. The first transfer track and the second transfer track are integrally formed or connected to each other; A control component configured to: according to the type of the measurement item of the sample in the sample container, control the sample transfer device to transfer the sample container to the first analyzer and / or the second analyzer for sample aspiration.

44. The sample analysis system according to claim 43, characterized in that: The second analyzer is a blood cell analyzer, and the blood cell analyzer is at least used to aspirate a sample from the sample container and perform blood cell analysis on at least a part of the aspirated sample; And / or, the sample analysis system further includes an information acquisition device configured to acquire information characterizing the type of the item to be measured of the sample in the sample container; the control component is configured to: determine the type of the item to be measured of the sample in the sample container according to the information characterizing the type of the item to be measured of the sample in the sample container fed back by the information acquisition device; and control the sample transfer device to transfer the sample container to the first analyzer and / or the second analyzer for sampling according to the type of the item to be measured of the sample in the sample container.

45. A control method for a liquid chromatography device, characterized in that: The method includes the following steps: Within a first preset time period after the chromatographic analysis item of a blood sample is completed, if no information indicating that there is another blood sample that needs to perform the chromatographic analysis item is obtained, control the locking and releasing device to switch from the released state to the locked state to prevent the potential energy storage and release component from releasing the stored potential energy, and control the first driving device to stop driving the liquid phase fluid to flow; After the locking and releasing device switches to the locked state, if information indicating that there is a blood sample that needs to perform the chromatographic analysis item is obtained, control the locking and releasing device to switch from the locked state to the released state, so that the potential energy storage and release component releases the stored potential energy to assist in driving the liquid phase fluid to flow toward the chromatographic column.

46. The control method of the liquid chromatography device according to claim 45, characterized in that: The control method further includes: before the first chromatographic analysis item after the liquid chromatography device is powered on, first control the first driving device to start and keep running for a third preset time period, so that the pressure of the liquid phase fluid flowing toward the chromatographic column reaches a target pressure value or a target pressure range; during the process of performing the chromatographic analysis item, control the first driving device to drive the liquid phase fluid to flow at the target pressure value or a pressure value within the target pressure range to elute the test solution adsorbed on the chromatographic column; The step of, if information indicating that there is a blood sample that needs to perform the chromatographic analysis item is obtained, controlling the locking and releasing device to switch from the locked state to the released state includes: first controlling the first driving device to start and keep running for a second preset time period, so that the pressure of the liquid phase fluid flowing toward the chromatographic column is greater than zero and less than the target pressure value or less than the lower limit of the target pressure range, and then controlling the locking and releasing device to switch from the locked state to the released state; The control method further includes: after controlling the locking and releasing device to switch from the locked state to the released state, first control the first driving device to continue to keep running for a fourth preset time period, so that the pressure of the liquid phase fluid flowing toward the chromatographic column substantially reaches the target pressure value or the target pressure range, and then control the switching valve to switch to a state of connecting the liquid phase fluid supply component, the test solution preparation channel and the chromatographic column, so that the liquid phase fluid supply component drives the test solution in the test solution preparation channel to be transported to the chromatographic column through the liquid phase fluid; Wherein, the sum of the second preset time period and the fourth preset time period is less than the third preset time period.

47. A control method for a liquid chromatography device, characterized in that: The method includes the following steps: In the process of performing a chromatographic analysis project on a sample, control the first driving device to drive the liquid-phase fluid to flow so as to elute the test solution adsorbed on the chromatographic column and made at least of the sample, and control the energy storage device to store potential energy through the pressure action of the liquid-phase fluid; After completing the chromatographic analysis project of the sample and when performing the chromatographic analysis project of the next sample, control the energy storage device to release the potential energy stored in the process of performing the chromatographic analysis project of the sample to assist in driving the liquid-phase fluid to flow towards the switching valve and the chromatographic column.

48. The control method of the liquid chromatography device according to claim 47, characterized in that: The control of the energy storage device to store potential energy through the pressure action of the liquid-phase fluid includes: controlling the locking and releasing device to be in the releasing state to allow the energy storage device to store potential energy through the pressure action of the liquid-phase fluid; The control of the energy storage device to release the potential energy stored in the process of performing the chromatographic analysis project of the sample after completing the chromatographic analysis project of the sample and when performing the chromatographic analysis project of the next sample includes: after completing the chromatographic analysis project of the sample, controlling the locking and releasing device to switch from the releasing state to the locking state to prevent the energy storage device from releasing the stored potential energy, and controlling the first driving device to stop driving the liquid-phase fluid to flow; after the locking and releasing device switches to the locking state and when performing the chromatographic analysis project of the next sample, controlling the locking and releasing device to switch from the locking state to the releasing state so that the energy storage device releases the potential energy stored in the process of performing the chromatographic analysis project of the sample.

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