Composition with robinin and hydrotrope agents

Abstract

The present invention relates to a cosmetic composition comprising: (a) at least one compound according to formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates, (b) at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent, and (c) water. It also relates to a method for care of the skin and / or mucosa comprising application of the composition according to the invention on the skin and / or mucosa.

Description

[0001] Composition with robinin and hydrotrope agents

[0002] The present invention relates to a cosmetic composition comprising:

[0003] (a) at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates,

[0004] (b) at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent, and

[0005] (c) water.

[0006] Human skin is composed of two compartments, namely a deep compartment (the dermis) and a surface compartment (the epidermis). The epidermis is in contact with the external environment, and it particularly has the role of protecting the body from dehydration and stress in particular external, chemical or mechanical stress.

[0007] There is still a need for novel cosmetic compositions having advantageous properties, in particular on the skin.

[0008] Robinin may be an advantageous active agent in this aim. Indeed, this type of active agent is known in cosmetics, for example from application EP4171476.

[0009] However, robinin is soluble in some solvents such as hot alcohols, which poses flammability and therefore safety problems. Robinin is soluble in hot water, but is not soluble in water at ambient temperature. Therefore, it does not allow, per se, the formulation of cosmetic compositions that are stable and applicable on the skin.

[0010] Therefore, the formulator seeks compositions comprising robinin which are stable and applicable in particular topically (i.e. on the skin and / or mucosa).

[0011] Such compositions must furthermore comprise a certain quantity of water, in order to be able to formulate robinin in a wide range of cosmetic substrates including lotions, gels or emulsions.

[0012] In this context, the inventors surprisingly discovered that particular hydrotrope agents allow the solubilization of robinin in water. Therefore, the aim of the invention is that of providing a cosmetic composition addressing these issues.

[0013] Thus, the present invention relates to a cosmetic composition comprising:

[0014] (a) at least one compound according to formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates:

[0015] [Chem 1] wherein:

[0016] - R’ and R”, identical or different, preferably different, represent a hydrogen or a (Ci- C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, or a monosaccharide or a polysaccharide including up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide optionally being substituted by an obligatorily free hydroxyl group, and / or optionally substituted by one or more optionally protected amine function(s), said monosaccharide or polysaccharide being optionally substituted on its - CH2OH group by a -C(O)-CC>2H group, and said monosaccharide or polysaccharide being optionally substituted on one or more of its hydroxy groups by a (Ci-C4)acyl group, preferably an acetyl group, or by a hydroxycinnamyl fragment, chosen from among coumaroyl, cafeoyl, feruloyl and sinapoyl;

[0017] - R’” and R””, identical or different, represent a hydrogen or a (Ci-C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, it being understood that R’, R”, R’” and R”” do not represent H at the same time,

[0018] (b) at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent, and

[0019] (c) water.

[0020] Preferably, the present invention relates to a cosmetic composition consisting of: (a) at least one compound according to formula (I) as defined above, or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates,

[0021] (b) at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent, and

[0022] (c) water.

[0023] The invention also relates to a method for care of the skin and / or mucosa comprising application of the composition according to the invention on the skin and / or mucosa.

[0024] The invention also relates to the use of a composition according to the invention for care of the skin and / or mucosa.

[0025] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99%, and more preferably from 70% to 95% with respect to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)). This final composition corresponds in particular to the marketed final cosmetic product.

[0026] The composition according to the invention is preferably presented in the form of a lotion, an emulsion or a gel.

[0027] According to the present invention, and unless indicated otherwise: a "sugar" radical is a monosaccharide or disaccharide radical. As sugar radical, mention may be made of: sucrose (or saccharose), glucose, galactose, rhamnose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose or lactose;

[0028] - "monosaccharide" means a mono-glycoside sugar comprising at least 5 carbon atoms of formula CX(H2O)X, where x is an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is between 5 and 7 inclusive, preferably x is 6. They may be D or L series, and of alpha or beta anomer, as well as one of their salts or their solvates such as hydrates;

[0029] - "disaccharide" means a di-glycoside sugar which is a compound consisting of two glycosides bonded together by O-glycosidic bonds, said compounds consisting of two monosaccharides (also referred to as mono-glycosides) as defined above, said monosaccharide units comprising at least 5 carbon atoms, preferably 6, particularly the mono-glycoside units are bonded together at 1 ,4 or 1 ,6 in a (alpha) or (beta) anomer, each glycoside unit being capable of being L or D series, as well as one of its salts or its solvates such as hydrates. A disaccharide is more particularly a polymer formed from two glycosides (or monosaccharides) having the following general formula: -[Cx(H2O)y)]2- or -[(CFW h-, where x is an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is between 5 and 7 inclusive, preferably x is 6, and y is an integer which represents x - 1 "transparent composition" means according to the present invention a composition having a turbidity value less than 200 NTU, preferably less than 150 NTU, preferably less than 100 NTU. Preferably, the turbidity of the compositions is equal to at least 1 NTU.

[0030] NTUs (nephelometric turbidity units) are units for measurement of the turbidity of a composition. The turbidity measurement is made, for example, with a model 2100P turbidity meter from Hach Company, the tubes used for the measurement being referenced AR397A cat 24347-06. The measurements are made at ambient temperature (from 20°C to 25°C). Preferably, the composition is transparent and has a turbidity value between 1 and 200 NTU, preferably between 1 and 150 NTU, and preferably less than 100 NTU;

[0031] - "skin" means facial skin and / or body skin, and the scalp;

[0032] - "appendages" means eyelashes, eyebrows, nails and hair, and particularly eyelashes and hair; hereinafter, and unless indicated otherwise, the ranges of values are inclusive, in particular in the expressions "between and" and "ranging from ... to ..."; moreover, the expression "at least one" used in the present description is equivalent to the expression "one or more".

[0033] Compound according to formula (I)

[0034] The compound according to the invention comprises at least one compound according to the following formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates:

[0035] [Chem 1] wherein:

[0036] - R’ and R”, identical or different, preferably different, represent a hydrogen or a (Ci- C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, or a monosaccharide or a polysaccharide including up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide optionally being substituted by an obligatorily free hydroxyl group, and / or optionally substituted by one or more optionally protected amine function(s), said monosaccharide or polysaccharide being optionally substituted on its - CH2OH group by a -C(O)-CC>2H group, and said monosaccharide or polysaccharide being optionally substituted on one or more of its hydroxy groups by a (Ci-C4)acyl group, preferably an acetyl group, or by a hydroxycinnamyl fragment, chosen from among coumaroyl, cafeoyl, feruloyl and sinapoyl;

[0037] - R’” and R””, identical or different, represent a hydrogen or a (Ci-C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, it being understood that R’. R”, R’” and R”” do not represent H at the same time.

[0038] Advantageously, R’ and R” are identical or different and represent a monosaccharide or a polysaccharide containing up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide having at least one obligatorily free hydroxyl function and / or optionally one or more obligatorily protected amine function(s).

[0039] Advantageously, the monosaccharide is chosen from D-glucose, D-allose, D- galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L-rhamnose, D- glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine, N-acetyl-D- galactosamine and advantageously denotes D-glucose, L-rhamnose, D-xylose, N-acetyl-D- glucosamine or L-fucose, and more preferably L-rhamnose.

[0040] Advantageously, the polysaccharide containing up to 6 sugar units is chosen from D-maltose, D-lactose, D-cellobiose, D-maltotriose, a disaccharide associating a uronic acid chosen from D-iduronic acid or D-glucuronic acid with a hexosamine chosen from D- galactosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, a disaccharide associating L-rhamnose and D-galactose, an oligosaccharide containing at least one xylose which may be advantageously chosen from xylobiose, methyl-p- xylobioside, xylotriose, xylotetraose, xylopentaose and xylohexaose and in particular xylobiose which is composed to xylose molecules bonded by a 1-4 bond.

[0041] More preferably, R’ and R” are different and represent a monosaccharide or a polysaccharide chosen from D-glucose, D-allose, D-xylose, L-fucose, L-rhamnose, D- galactose, and D-maltose, preferably L-rhamnose and D-galactose in monosaccharide or disaccharide form. More preferably R’ represents a monosaccharide such as L-Rhamnose and R” represents a disaccharide such as a disaccharide associating L-Rhamnose and D- galactose.

[0042] Preferably, R’” and R”” represent a hydrogen.

[0043] The monosaccharide and / or polysaccharide of R’ and / or R” may be substituted on one or more hydroxymethyl residue(s) by a -C(O)-COOH group.

[0044] The salt of the compound according to formula (I) may be an alkali metal salt or an alkaline-earth metal salt, preferably a calcium, magnesium, sodium or potassium salt.

[0045] Preferably, the compound according to formula (I) or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates is chosen from robinin and its salts.

[0046] The compound according to formula (I) or one of its optical isomers, or its cis-trans isomer (such as an alpha or beta anomer), or its tautomer, or its salt, or its hydrate, preferably robinin or one of its salts, is present in solubilized form in the composition. "In solubilized form" means that the compound does not form crystals visible to the naked eye in the composition.

[0047] Robinin (C33H40O19) (or Kaempferol-3-o-gal-rham-7-o-rham, or 3-[[6-o-(6-deoxy-a-l- mannopyranosyl)-p-d-galactopyranosyl]oxy]-7-[(6-deoxy-a-l-mannopyranosyl)oxy]-5- hydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one) is the compound according to the following formula (I):

[0048] [Chem 2]

[0049] Robinin can exist in two a and p anomer forms.

[0050] The compound according to formula (I) is the anomer of robinin.

[0051] Robinin may also be presented in salt form.

[0052] Preferably, the composition according to the invention comprises robinin or one of its salts in p form. Preferably, the compound according to formula (I) or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates is chosen from robinin and its salts in p form.

[0053] Robinin is a molecule derived from kaempferol. It is a flavone presented in the form of an orange-yellow powder. This molecule is for example present in the leaves and seeds of black locust (Robinia pseudoacacia).

[0054] Robinin is for example marketed by INTERCHIM under the name NAVQll®, or by SIGMA under the name Robinin®.

[0055] Preferably, the composition comprises between 0.1 and 10% by weight of compound according to formula (I) or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates, preferably of robinin or one of its salts, with respect to the total weight of the composition, preferably between 0.2 and 8% by weight, preferably between 0.3 and 5% by weight, preferably between 0.4 and 4% by weight, and more preferably between 0.4 and 1 % by weight.

[0056] Hydrotrope agent The composition according to the invention comprises at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent.

[0057] Preferably, the composition according to the invention comprises at least 6% by weight with respect to the total weight of the composition of at least two hydrotrope agents.

[0058] Preferably, the hydrotrope agents are cosmetically acceptable hydrotrope agents.

[0059] "Hydrotrope" or "hydrotrope agent" means a water-soluble compound which has an amphiphilic molecular structure and which is capable of considerably increasing the solubility of organic molecules slightly soluble in water. A hydrotrope is different from a polymer (i.e. chemical compound that is constituted of repetitions of a structural unit and having a molar mass greater than 10 000 g / mol). A hydrotrope is a small molecule; typically it presents a molar mass comprised between 1 and 600 g / mol.

[0060] Hydrotropes are like surfactants, but are distinguished by their hydrophobic part which is shorter and does not make it possible to induce spontaneous autoagreggation. Unlike surfactants, these compounds do not have a critical micellar concentration.

[0061] Among the hydrotrope agents known from the prior art, mention may be made of sodium 1 ,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate (sodium PCA), sodium salicylate, sodium benzene sulfonate, caffeine, sodium p-toluene sulfonate, sodium butyl monoglycolsulfate, 4-aminobenzoic acid and its HCI salt, sodium cumene sulfonate, N,N-diethylnicotinamide, N-picolylnicotinamide, N-allylnicotinamide, 2- methacryloyloxyethyl phosphorylcholine, resorcinol, urea, hydroxyethyl urea, N,N-dimethyl urea, pyrogallol, N-picolylacetamide 3.5, procaine hydrochloride, proline hydrochloride, niacinamide (or nicotinamide), pyridine, 3-picolylamine, ibuprofen sodium, sodium xylene sulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N,N-dimethylacetamide, N-methylacetamide or isoniazide.

[0062] A list of hydrotropes is detailed in the following publications: Lee J. et al, "Hydrotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property", Pharmaceutical Research, Vol. 20, No. 7, 2003, Lee S. et al., "Hydrotropic Polymers: Synthesis and Characterization of Polymers Containing Picolylnicotinamide Moieties", Macromolecules, 36, 2248-2255, 2003, and Hodgon T.K., Kaier E.W., "Hydrotropic Solutions", Current Opinion in Colloid and Interface Science, 12, 121-128, 2007.

[0063] Cosmetically acceptable hydrotropes denote hydrotropes which are compatible with a cosmetic application, i.e. application on the skin, mucosa and / or skin appendages. Preferably, the suitable hydrotrope according to the invention is chosen from the following hydrotropes and mixtures thereof:

[0064] [Table 1] Preferably, the composition according to the invention comprises at least one hydrotrope agent chosen from caffeine, niacinamide and mixtures thereof.

[0065] Preferably, the composition according to the invention comprises a mixture of caffeine and niacinamide.

[0066] Preferably, caffeine and niacinamide are present in the composition according to the invention in a caffeine: niacinamide weight ratio between 1 :1 and 1 :2. Preferably, the quantity of hydrotrope agent(s) in the composition according to the invention is between 6 and 20% by weight with respect to the total weight of the composition, preferably between 6 and 15% by weight, preferably between 6 and 10% by weight.

[0067] Preferably, the weight ratio of hydrotrope agent(s): compound according to formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates in the composition according to the invention is at least 12:1.

[0068] Preferably, the weight ratio of hydrotrope agent(s): robinin in the composition according to the invention is at least 12:1.

[0069] Water

[0070] The composition according to the invention comprises water.

[0071] The water used may be sterile demineralized water and / or floral water such as rose water, cornflower water, chamomile water or linden water, and / or a spring or natural mineral water, such as VITTEL water, LUCAS water or LA ROCHE POSAY water.

[0072] The composition preferably comprises at least 30% by weight of water, preferably at least 50% by weight, preferably at least 60% by weight, preferably at least 70% by weight.

[0073] The composition preferably comprises from 15% to 98% by weight of water with respect to the total weight of the composition, more preferably from 30% to 95% by weight, even more preferably from 50% to 90% by weight.

[0074] The composition according to the invention may also contain usual ingredients in the cosmetics field, such as preservatives, perfumes, fillers, oils, waxes, pasty fats, sun protection filters or UV filters, odor absorbers, dyestuffs, alkaline agents, sequestering agents, or active agents.

[0075] The quantities of these various ingredients are conventionally the quantities used in the field considered, for example from 0.01 to 20% of the total weight of the composition. These ingredients, depending on their nature, may be introduced into the oily phase and / or into the aqueous phase. Obviously, those skilled in the art will take care to choose the optional compound(s) to add to the composition according to the invention and their quantities in such a way that the advantageous properties intrinsically associated with the composition according to the invention are not altered, or are not substantially altered, by the envisaged addition.

[0076] The composition according to the invention may be obtained conventionally by those skilled in the art.

[0077] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight with respect to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)), preferably from 60 to 99% by weight, more preferably from 70 to 95% by weight. The final composition corresponds in particular to the marketed final cosmetic product, based on robinin. Cosmetically acceptable medium means a medium compatible with the skin and / or its appendages.

[0078] The invention also relates to a method for care of the skin and / or mucosa comprising application of the composition according to the invention or the final composition according to the invention on the skin and / or mucosa.

[0079] The invention also relates to the use of a composition according to the invention or the final composition according to the invention for care of the skin and / or mucosa.

[0080] The following examples make it possible to understand the invention better, without being in any way limitative. The raw materials are referred to with the chemical or INCI name thereof. The quantities indicated are as a % by weight of raw materials with respect to the total weight of the composition (% w / w), unless specified otherwise.

[0081] Examples

[0082] Example 1 : preparation of compositions according to the invention and evaluation compared to comparative compositions

[0083] Comparative compositions A, B, C and D and compositions E, F, G and H according to the invention were prepared. Comparative compositions A, B, C and D have a quantity of hydrotrope agents (i.e. caffeine and niacinamide) strictly less than 6% by weight with respect to the total weight of the composition.

[0084] 5 Compositions E, F, G and H according to the invention have a quantity of hydrotrope agents greater than or equal to 6% by weight with respect to the total weight of the composition.

[0085] The compositions in Table 2 were prepared according to the following protocol:

[0086] - a hydrotrope solution is produced by mixing caffeine and niacinamide in water, then

[0087] 10 - robinin is solubilized by sprinkling in the hydrotrope solution under magnetic stirring and heated to a maximum temperature of 50°C.

[0088] The niacinamide used is Niacinalide PC® marketed by DSM NUTRITIONAL PRODUCTS.

[0089] The caffeine used is CAFFEINE POWDER® marketed by CSPC Innovation

[0090] 15 Pharmaceutical.

[0091] [Table 2]

[0092] The results show that robinin is soluble in water when the overall quantity of hydrotrope 20 agents in the composition is greater than or equal to 6% by weight with respect to the total weight of the composition.

[0093] On the other hand, robinin is not soluble in water when the overall quantity of hydrotrope agents in the composition is less than 6% by weight with respect to the total weight of the composition.

[0094] 25

[0095] Example 2: preparation of a composition according to the invention in gel form

[0096] The composition described in Table 3 hereinafter is prepared according to the following protocol: - Phase A is prepared by mixing niacinamide in a portion of the water for 2 minutes at 40 °C, then adding caffeine and mixing further for 20 minutes at 40°C,

[0097] - Robinin (B) is then solubilized in the mixture,

[0098] - The compounds of phase C are added and mixed for 3 minutes at 230 rpm, - The compounds of phase D are added by mixing at 230 rpm and heating to 40°C for 5 min until a smooth and shiny gel is obtained.

[0099] - Water is added and mixed for 2 minutes at 500 rpm.

[0100] [Table 3]

[0101] The viscosity is measured with a Rheomat RM 180 spindle 3, at ambient temperature (approximately 20°C). The viscosity value of the composition is read at 30 seconds and 10 minutes. The composition obtained is a translucent gel, the application of which on the skin is pleasant, and wherein robinin has indeed been solubilized.

Claims

CLAIMS1. Cosmetic composition comprising:(a) at least one compound according to formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates:[Chem 1]wherein:- R’ and R”, identical or different, preferably different, represent a hydrogen or a (Ci- C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, or a monosaccharide or a polysaccharide including up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide optionally being substituted by an obligatorily free hydroxyl group, and / or optionally substituted by one or more optionally protected amine function(s), said monosaccharide or polysaccharide being optionally substituted on its - CH2OH group by a -C(O)-CC>2H group, and said monosaccharide or polysaccharide being optionally substituted on one or more of its hydroxy groups by a (Ci-C4)acyl group, preferably an acetyl group, or by a hydroxycinnamyl fragment, chosen from among coumaroyl, cafeoyl, feruloyl and sinapoyl;- R’” and R””, identical or different, represent a hydrogen or a (Ci-C4)alkyl group for example chosen from among methyl, ethyl, propyl, isopropyl, butyl and isobutyl, preferably a methyl, it being understood that R’, R”, R’” and R”” do not represent H at the same time,(b) at least 6% by weight with respect to the total weight of the composition of at least one hydrotrope agent, and(c) water.

2. Composition according to claim 1 , wherein the compound according to formula (I) or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates is chosen from robinin and its salts, preferably in p form.

3. Composition according to claim 1 or 2, which comprises between 0.1 and 10% by weight of compound according to formula (I) or one of its optical isomers, its cistrans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates, preferably with respect to the total weight of the composition, preferably between 0.2 and 8% by weight, preferably between 0.3 and 5% by weight, preferably between 0.4 and 4% by weight.

4. Composition according to one of the preceding claims, which comprises at least two hydrotrope agents.

5. Composition according to one of the preceding claims, wherein the quantity of hydrotrope agent(s) is between 6 and 20% by weight with respect to the total weight of the composition, preferably between 6 and 15% by weight, preferably between 6 and 10% by weight.

6. Composition according to one of the preceding claims, wherein the weight ratio of hydrotrope agent(s): compound according to formula (I), or one of its optical isomers, its cis-trans isomers (such as an alpha or beta anomer), tautomers, or one of its salts or hydrates, preferably the weight ratio of hydrotrope agent(s): robinin, is at least 12:1.

7. Composition according to one of the preceding claims, which comprises at least one hydrotrope agent chosen from niacinamide, caffeine, urea, sodium PCA, sodium salicylate, hydroxyethyl urea and mixtures thereof.

8. Composition according to one of the preceding claims, which comprises at least one hydrotrope agent chosen from caffeine, niacinamide and mixtures thereof.

9. Composition according to one of the preceding claims, which comprises a mixture of caffeine and niacinamide in a caffeine: niacinamide weight ratio between 1 :1 and 1 :2.

10. Composition according to one of the preceding claims, which comprises from 15% to 98% by weight of water with respect to the total weight of the composition, preferably from 30% to 95% by weight, preferably from 50% to 90% by weight.

11. Composition according to one of the preceding claims, in the form of a lotion, an emulsion or a gel.

12. Final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99%, more preferably from 70% to 95% with respect to the total weight of the composition of a composition according to one of claims 1 to 11.

13. Method for care of the skin and / or mucosa comprising application of the composition according to one of the claims 1 to 11 or 12 on the skin and / or mucosa.

14. Use of a composition according to one of claims 1 to 11 or 12 for care of the skin and / or mucosa.

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