Amino acid-based technology to enhance plant performance

Abstract

The disclosure relates to methods and compositions for improving plant growth. Agricultural compositions and methods of producing and applying them are disclosed.

Description

ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 AMINO ACID-BASED TECHNOLOGY TO ENHANCE PLANT PERFORMANCE CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority to U.S. Provisional Application No. 63 / 625,813, filed on January 26, 2024, the entire contents of which are incorporated herein by reference. FIELD OF THE DISCLOSURE

[0002] The disclosure relates to compositions for improving plant productivity and / or harvestable crop value and methods of application. BACKGROUND

[0003] Fertilizers are ubiquitous throughout the agricultural industry to promote plant growth such that healthier plants and higher yields may be achieved. Generally, fertilizers provide nitrogen (N), phosphorus (P), and / or potassium (K), along with other nutrients, to the plant, whether it be in solid (e.g., granule or powder) or liquid form.

[0004] However, many commercially available fertilizers are limited in their ability to improve plant yield and overall growth characteristics. Thus, there continues to be a need for compositions capable of improving plant growth and yield. BRIEF SUMMARY

[0005] In one aspect, the present disclosure provides an agricultural composition comprising: a) a proteogenic amino acid; b) a non-proteogenic amino acid; c) a desert plant extract; and d) an algae extract.

[0006] In one aspect, the present disclosure provides an agricultural composition comprising: a) an amino acid mixture comprising proteogenic and non-proteogenic amino acids; b) a desert plant extract; c) an algae extract; d) and sugar.

[0007] In one aspect, the present disclosure provides an agricultural composition comprising: a) 0.1-10% w / w desert plant extract; b) 0.05-5% w / w GABA; c) 0.1-5% w / w Kelp extract; d) 0.1-15% w / w sugar; and e) 0.5-10% w / w protein hydrolysates; f) 10-50% w / w potassium acetate; and g) 0.5-20% w / w urea.

[0008] In one aspect, the present disclosure provides a composition comprising: (a) a compound of Formula (I) having the structure:ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 (I), or a stereoisomer thereof,R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6- membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2; and (b) one or more additives.

[0009] In one aspect, the present disclosure provides a method of preparing a compound of Formula (I-1) having the structure: , the methodacid (2) under acidic conditions and at a temperature greater that 40°C, according to the following reaction scheme: .one a a according to any one of the foregoing embodiments.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0011] In one aspect, the present disclosure provides a method of growing a plant, said method comprising applying the composition of any one of the foregoing embodiments to a plant. BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

[0012] The accompanying figures, which are incorporated herein and form a part of the specification, illustrate some, but not the only or exclusive, example embodiments and / or features. It is intended that the embodiments and figures disclosed herein are to be considered illustrative rather than limiting.

[0013] FIG. 1A-1B show results from the application of an illustrative composition of the disclosure on cotton plants, in comparison to the grower standard and a commercially available crop additive product. FIG.1A shows the overall boll count per cotton plant. FIG. 1B shows the total boll weight per cotton plant. Results are averaged across three plants per condition.

[0014] FIG. 2A-2D show results from the application of an illustrative composition of the disclosure on soybean plants, in comparison to the grower standard and a commercially available crop additive product. FIG. 2A shows the total pods per soybean plant. FIG. 2B shows the distribution of pods with 1, 2, 3, or 4 seeds per soybean plant. FIG. 2C shows the total pod weight per soybean plant. FIG. 2D shows the total root mass per soybean plant. Results are averaged across three plants per condition.

[0015] FIG. 3A-3D show the results of field trials of an agricultural composition of the disclosure on cotton plants. FIG. 3A and FIG. 3B show the total number of bolls and boll weight, respectively, for control compared to application of the agricultural composition at 3rdleaf and first bloom. FIG. 3C and FIG. 3D show the total number of bolls and boll weight, respectively, for control compared to application of the agricultural composition at 5thleaf.

[0016] FIG. 4A-4B show the results of field trials of an agricultural composition of the disclosure on peanut plants. FIG. 4A shows total nut weight for control and treated groups, while FIG.4B shows the count of 1 nut shells, 2 nut shells, and total nut shells for control and treated groups.

[0017] FIG. 5 shows the yield results of field trials of an agricultural composition of the disclosure on corn plants in terms of bushels per acre.

[0018] FIG. 6A-6B show the results of field trials of an agricultural composition of the disclosure on soybeans. FIG.6A shows the distribution of beans per pod per treatment group, while FIG.6B shows total pod counts per treatment group.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0019] FIG. 7A-7B show the results of field trials of an agricultural composition of the disclosure on soybeans. FIG.7A shows the distribution of beans per pod per treatment group, while FIG.7B shows total pod counts per treatment group.

[0020] FIG. 8A-8C show the results of field trials of an agricultural composition of the disclosure on soybeans. FIG.8A shows total pods, FIG.8B shows total pod weight, and FIG. 8C shows the distribution of number of beans per pod.

[0021] FIG. 9A-9C show the results of field trials of an agricultural composition of the disclosure on soybeans. FIG.9A shows total pods, FIG.9B shows total pod weight, and FIG. 9C shows the distribution of number of beans per pod. DETAILED DESCRIPTION

[0022] All publications, patents and patent applications, including any drawings and appendices, are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

[0023] The following description includes information that may be useful in understanding the present disclosure. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed disclosures, or that any publication specifically or implicitly referenced is prior art. Definitions

[0024] As used herein, the term “about” refers to plus or minus 10% of the referenced number, unless otherwise stated or otherwise evident by the context (such as when a range would exceed 100% of a possible value or fall below 0% of a possible value). For example, reference to an absolute content of a fertilizer ingredient of “about 1%” means that that ingredient can be present at any amount ranging from 0.9% to 1.1% content by weight. The term “about” also refers to plus or minus a day when referring to a length of time measured in days.

[0025] The term "a" or "an" refers to one or more of that entity; for example, “a solvent” refers to one or more solvents or at least one solvent. As such, the terms "a" (or "an"), "one or more" and "at least one" are used interchangeably herein. In addition, reference to “an element” by the indefinite article "a" or "an" does not exclude the possibility that more than one of the elements is present, unless the context clearly requires that there is one and only one of the elements.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0026] The International Code of Zoological Nomenclature defines rank, in the nomenclatural sense, as the level, for nomenclatural purposes, of a taxon in a taxonomic hierarchy (e.g., all families are for nomenclatural purposes at the same rank, which lies between superfamily and subfamily). While somewhat arbitrary, there are seven main ranks defined by the international nomenclature codes: kingdom, phylum / division, class, order, family, genus, and species. Overview

[0027] The disclosure relates to compositions for improving plant health and productivity, wherein the composition is an agricultural composition comprising a) proteogenic amino acids; b) non-proteogenic amino acids; c) desert plant extract; and d) a chelating agent. The disclosure further relates to methods of using the compositions for improving plant health and / or productivity. Methods of making such compositions are also described. Proteogenic amino acids

[0028] The present disclosure provides agricultural compositions comprising proteogenic amino acids. Proteogenic amino acids are amino acids that are incorporated biosynthetically into proteins during translation. The proteogenic amino acids are: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine.

[0029] In some embodiments, the proteogenic amino acids comprised by the agricultural composition are provided by a protein hydrolysate. In some embodiments, the hydrolysate is soy protein hydrolysate. In some embodiments, the proteogenic amino acids are provided by corn steep.

[0030] In some embodiments, the proteogenic amino acids comprised by the agricultural composition are provided by corn steep liquor. Corn steep liquor (CSL) is a dense liquid, typically with specific gravity of around 1.25 and with a pH of around 3.7 to 4.1. CSL has nitrogen in the form of amino acids and peptides, macro and micronutrients, and vitamins. Most corn steep liquors have a nitrogen content around 4% mostly in the form of amino acids (alanine, arginine, aspartic acid, cystine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine tyrosine, and valine) and polypeptides. It also has around 3% of phosphorus and potassium. CSLs also have a low sugar content (1 to 2%) and high lactic acid content (13 to 15%), a result of fermentation in the steep water by lactic acid bacteria. The NPK content varies due to corn quality and processing differences between mills. CSL contains considerable amounts of B-complex vitamins such as riboflavin, niacin,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 pantothenic acid, pyridoxine, and biotin with the exception of thiamine. Vitamins play important roles when converted into cofactors for enzymes that are involved in stress reduction, nitrogen metabolism, nutrient transport, and photosynthesis. CSL also typically has very low amounts of heavy metals such as Al, Ce, Cu, Fe, Pb, Mn, Mo, and Zn, low amounts of S, and moderate amounts of Mg (around 1%), and P (2-3%) (see world wide web at growerssecret.com / corn-steep-liquor-and-powder-fertilizers).

[0031] In some embodiments, the agricultural composition comprises corn steep powder. Corn Steep Powder (CSP) is a fine, yellow to yellow-brown, water-soluble powder made by spray drying corn steep liquor (CSL). Corn steep liquor is a concentrated liquid derived from the water that is used in the initial stage of the corn wet milling process. Once considered a waste stream by-product, its properties lent well for other uses. In some embodiments, both CSP and CSL comprise protein hydrolysates.

[0032] In some embodiments, the proteogenic amino acids comprised by the agricultural composition are provided by protein hydrolysates. Protein hydrolysates (PHs) are mixtures of polypeptides, oligopeptides, and amino acids as produced from the partial hydrolysis of protein sources (Shubhpriya et al. Chapter 1 - Categories of various plant biostimulants – mode of application and shelf-life, Biostimulants for Crops from Seed Germination to Plant Development, Academic Press, 2021). PHs are classified based on their protein source and techniques applied for their hydrolysis (e.g., chemical, thermal, or enzymatic hydrolysis).

[0033] Persons having skill in the art will be familiar with methods of producing protein hydrolysates, a representative number of which are described herein. Chemical Hydrolysis

[0034] In some embodiments, the protein hydrolysate is produced via chemical hydrolysis. Until recently, the production of PHs was mainly carried out chemically, employing acid or basic hydrolysis at high temperatures. Acid hydrolysis is usually carried out by using 6 M HCl at 110°C for more than 24 hours leading to the degradation of some amino acids, namelyarginine and tryptophan, and causes the formation of unwanted secondary compounds such as chlorides (Corte et al., Journal of the Science of Food and Agriculture, 94(2), 235-245.). Similarly, alkaline hydrolysis, conducted with strong bases, namely NaOH or KOH, causes the degradation of amino acids such as cysteine, arginine, threonine, serine, and isoleucine and also leads to the formationATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 of modified amino acids such as lysinoalanine and lanthionine (Tavano, O.L. (2013). Journal of Molecular Catalysis B: Enzymatic, 90, 1-11). Microbial Hydrolysis

[0035] In some embodiments, the protein hydrolysate is produced via microbial hydrolysis. Another viable route to the preparation of PHs is based on the use microorganisms, which, through the action of specific enzymes such as proteases, lead to the formation of small peptides and free amino acids. Microorganisms are endowed with a whole series of enzymatic capabilities that enable the degradation of organic matter, not only of protein origin but also polysaccharides and lipids (Hou et al., 2017, Journal of Animal Science and Biotechnology, 8(1), 24). The microbiological hydrolysis of the biomass protein component is divided into liquid or solid depending on the percentage of humidity of the substrate used; as a rule, what varies is the microbial flora involved. Enzymatic hydrolysis

[0036] In some embodiments, the protein hydrolysate is produced via enzymatic hydrolysis. PHs can also be obtained enzymatically by resorting to purified enzymes in their free or immobilized form. In this case, the hydrolysis process is again more advantageous than the chemical one, since it is carried out under mild conditions of temperature (40-60°C) and pH (6-8), resulting extremely favourable from an economic and environmental point of view. Enzymatic hydrolysis does not lead to the formation of unwanted and often toxic secondary products and, just like microbial hydrolysis, preserves the structure of the amino acids, which maintain their biologically active form (Clemente et al., 2000, Trends in Food Science & Technology, 11(7), 254-262).

[0037] In some embodiments, the hydrolysates obtained through the enzymatic approach also tend to be more soluble, more resistant to heat and more resistant to precipitation (Clemente et al., 2000). The most preferred enzymes for the preparation of PHs are proteases of microbial origin, composed of exopeptidases and endopeptidases according to the type of catalytic reaction performed; in fact, the exopeptidases make cuts at the level of the terminal region of the protein, while endopeptidases give internal cuts (Hou et al., 2017, Journal of Animal Science and Biotechnology, 8(1), 24). The enzymes involved in the production of PHs can derive from animal, vegetable or microbial sources. Pancreatin, trypsin, and pepsin are the main proteolytic enzymes obtained from animal sources, while papain and bromelain are extracted from plant organisms. Bacteria and fungi, however, represent the largest source of proteolytic enzymes, as they release enzymes directlyATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 into the extracellular environment, making the latter easier to extract. Moreover, proteases of bacterial and fungal origin exhibit a large range of optimal temperatures and pH (Journal of Animal Science and Biotechnology, 8(1), 24).

[0038] For example, the PHs produced enzymatically from perilla seed meal (PSM), a by-product of the production of perilla seed oil, were found to have a very high content of essential amino acids (e.g. lysine). Another example is the partial hydrolysis of quinoa protein (QP) isolates, by means of a fungal serin peptidase, for the production of QP hydrolysates to be used as food additives in semi-solid healthy foods with both antioxidant activity and gelling capability (Galante et al., 2020m, LWT, 118, 108845).

[0039] In some embodiments, the present disclosure is compatible with a variety of protein hydrolysates known to those having skill in the art. A non-limiting list of protein hydrolysates is provided in Table 1. Table 1. Hydrolysates Protein source Hydrolysates References or peptides of nt ssATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Protein source Hydrolysates References or peptides n , n S. f S. n kATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Non-proteogenic amino acid

[0040] The present disclosure provides agricultural compositions comprising non-proteogenic amino acids. Non-proteogenic amino acids are amino acids other than those that are incorporated biosynthetically into proteins during translation.

[0041] In some embodiments, the non-proteogenic amino acid comprises 2-aminoadipic acid, 2-aminobutyric acid, 2-aminopimelic acid, 3-aminobutyric acid, 3-aminopropionic acid, 4- aminobutyric acid, 6-aminocaproic acid, azetidine-2-carboxylic acid, beta-alanine, canaline, citrulline, gamma-aminobutyric acid (GABA), hydroxylysine, hydroxyproline, homocysteine, homoserine, isovaline, L-3,4-dihydroxyphenylalanine (L-DOPA), norleucine, norvaline, ornithine, pipecolic acid, sarcosine, selenocysteine, selenomethionine, or taurine.

[0042] In some embodiments, the non-proteogenic amino acid comprises γ-aminobutyric acid (GABA), selenomethionine or a derivate thereof, ornithine, selenocystine, pipecolic acid or a derivate thereof, or L-3,4-dihydroxyphenylalanine (L-DOPA).

[0043] In some embodiments, the non-proteogenic amino acid comprises GABA.

[0044] In some embodiments, the present disclosure teaches an agricultural composition comprising γ-Aminobutyric Acid (GABA). GABA is a four-carbon non-protein amino acid ubiquitous in organisms, and it is a zwitterion containing amino and carboxyl groups. γ-GABA can provide nutrients for plants, regulate plant growth and development, induce ethylene production, regulate cell fluid concentration in plants, and participate in many stress-resistant responses, such as resistance to salt stress, high-temperature stress, and low-temperature stress and resistance to drought stress. Additional information on GABA is available at doraagri.com / fertilizer-synergist-gamma-aminobutyric-acid-gaba-in-agriculture.

[0045] In some embodiments, adding GABA to soil and / or spraying GABA can reduce the nitrate content in plants, accelerate the development process, increase the activity of nitrate reductase, accelerate the consumption of soluble sugar, promote protein synthesis, and then improve crop yield and quality. GABA combined with chemical fertilizer application can achieve the effect of reducing fertilizer usage and efficiency enhancement. See Guo Z, Gong J, Luo S, Zuo Y, Shen Y. Role of Gamma-Aminobutyric Acid in Plant Defense Response. Metabolites.2023 Jun 10;13(6):741. Desert Plant Extract

[0046] In some embodiments, the present disclosure teaches an agricultural composition comprising a desert plant extract. As used herein, the term desert plant extract refers to extractsATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 from one or more plants found in any of the North American desserts. Without wishing to be bound by any theory, the present inventors believe that the desert plant extract provides valuable nutrients and compounds capable of enhancing plant growth.

[0047] In some embodiments, the desert plant extract comprises extracts from one or more plants of the following genera: Abronia, Acacia, Agave, Baileya, Berberis, Bursera, Carnegiea, Chilopsis, Dasylirion, Echinocactus, Encelia, Eremophila, Euphorbia, Ferocactus, Flourensia, Fouquieria, Hesperocallis, Larrea, Oenothera, Opuntia, Parkinsonia, Salvia, Stenocereus, Xerophyllum, and Yucca.

[0048] In some embodiments, the desert plant extract comprises extracts from one or more plants from the group consisting of: Acacia rigidula, Agave sp., Aloe dichotomum, Barrel cactus (Echinocactus sp. and Ferocactus sp.), Beargrass (Xerophyllum tenax), Berberis trifoliolata, Brittle bush (Encelia farinosa), Candelilla (Euphorbia antisyphilitica), Cholla Cactus (Opuntia), Creosote bush (Larrea tridentata), Desert lily (Hesperocallis undulata), Desert marigold (Baileya spp.), Desert sage (Salvia dorrii), Desert spoon (Dasylirion wheeleri), Desert willow tree (Chilopsis linearis), Dune Primrose (Oenothera deltoides), Elephant tree (Bursera microphylla), Eremophila glabra, Euphorbia antisyphilitica, Ferocactus pilosus, Fishhook barrel cactus (Ferocactus wislizeni), Mahonia trifoliolata, Organ pipe cactus (Stenocereus thurberi), Ocotillo (Fouquieria splendens), Palm plants, Palo verde (Parkinsonia sp.), Prickly pear cactus (Opuntia sp.), Saguaro cactus (Carnegiea gigantea), Sand Verbena (Abronia villosa), Sotol (Dasylirion sp.), Tarbush (Flourensia cernua), and Yucca sp.

[0049] In some embodiments, the desert plant extract comprises an extract from a plant from the group consisting of: Elephant tree (Bursera microphylla), Organ pipe cactus (Stenocereus thurberi), Desert sage (Salvia dorrii), Desert lily (Hesperocallis undulata), Desert willow tree (Chilopsis linearis), Palm tree (all species), Barrel cactus (Echinocactus sp. and Ferocactus sp.), Yucca sp., Saguaro cactus (Carnegiea gigantea), Creosote bush (Larrea tridentata), Agave sp., Brittle bush (Encelia farinosa), Ferocactus pilosus, Ocotillo (Fouquieria splendens), Aloe dichotomum, Acacia rigidula, Fishhook barrel cactus (Ferocactus wislizeni), Euphorbia antisyphilitica, Prickly pear cactus (Opuntia sp.), Palo verde (Parkinsonia sp.), Desert spoon (Dasylirion wheeleri), Tarbush (Flourensia cernua), Candelilla (Euphorbia antisyphilitica), Beargrass (Xerophyllum tenax), and Sotol (Dasylirion sp.).ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0050] In some embodiments, the Yucca species is Joshua Tree (Yucca brevifolia). In some embodiments, the Agave species is Agave americana, Agave parryi, Agave tequilana, Agave utahensis, Agave chrysantha, Agave victoriae-reginae, Agave toumeyana, or Agave lechuguilla. In some embodiments, the palm plant is a species of Sabal, Pseudopheoenix, Washingtonia, Coccothrinax, Thrinax, Leucothrinax, Rhapidophysllum, Sereno, Acoelorrhaphe, or Roystonea.

[0051] In some embodiments, the palm plant is Pseudophoenix sargentii, Washingtonia filifera, Sabal palmetto, Sabal minor, Coccothrinax argentata, Thrinax parviflora, Leucothrinax morrisii, Sabal louisiana, Rhapidophyllum hystrix, Acoelorrhaphe wrightii, Roystonea regia, Sabal etonia, Serenoa repens, or Sabal Mexicana.

[0052] Persons having skill in the art will be familiar with the many methods available for making plant extracts, including maceration, digestion, decoction, infusion, percolation, Soxhlet extraction, superficial extraction, ultrasound-assisted, and microwave-assisted extractions. Additional methods of extraction are discussed in later sections of this disclosure. Desert plants extracts are also commercially available, including at world wide web bulknaturalswholesale.com / products / american-desert-plant-extract-water-soluble. Chelating Agent

[0053] In some embodiments, the present disclosure teaches an agricultural composition comprising a chelating agent.

[0054] In agriculture, chelation is used to improve plant nutrient uptake by making certain nutrients more available to plants. This is particularly useful in soils deficient in certain nutrients, such as iron or zinc. Chelating agents are used to chelate micronutrients, such as iron, copper, zinc, and manganese, making them more soluble and available for plant uptake. This process can improve plant growth and development, as well as increase crop yield and quality.

[0055] For example, iron deficiency is a problem in many crops, particularly in alkaline soils. In this case, iron chelating agents can be applied to the soil or foliage of a wide variety of crops to improve iron uptake for the crop. Similarly, zinc chelating agents can be used to address zinc deficiencies in crops. Additional descriptions of chelating agents in agricultures can be found at andersonsplantnutrient.com / agriculture / market-feed / 4911.

[0056] Persons having skill in the art will be familiar with chelating agents amenable for agricultural use. A non-limiting list of chelating agents compatible with the present invention are provided herein.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0057] In some embodiments, the agricultural composition comprises a chelating agent selected from the group consisting of AB-DTPA (Ammonium Bicarbonate Diethylene Triamine Penta Acetic acid), DTPA (Diethylenetriamine penta acetic acid), EDTA- (Ethylenediaminetetraacetic acid), sodium gluconate, sodium glucoheptonate, glucoheptonate, and Fe-EDTA.

[0058] In some embodiments, the agricultural composition comprises a citric chelating agent. Citric chelating agent are derived from citric acid, a weak organic acid found in many fruits and vegetables. Citric acid is an effective chelator of metals but does not typically interact directly with NPK fertilizers or change them except that it helps absorb these nutrients more efficiently. In some embodiments, citric does not cause a long-term pH change to the potting media because the plants absorb and use most of the citric acid.

[0059] In some embodiments, the agricultural composition comprises humic and / or fulvic acids. Humic and fulvic acids are organic acids found in soil, peat, and other natural sources. Humic and fulvic acids can chelate both applied nutrients and nutrients in the soil, making them more available for plant use.

[0060] In some embodiments, the agricultural composition comprises ammoniated chelating agents. Ammoniated chelating agents are chelating agents that contain both a metal ion and ammonia groups. The metal ion, typically iron, zinc, copper, or manganese, is bound to the chelating agent molecule through a chelation process, while the ammonia groups help to stabilize the metal ion and make it more available.

[0061] In some embodiments, the agricultural composition comprises EDTA. EDTA stands for ethylenediaminetetraacetic acid, a synthetic compound that can chelate metal ions. They are particularly useful for chelating micronutrients, such as iron, zinc, copper, and manganese which help improve crop growth and overall crop quality and yields.

[0062] In some embodiments, the agricultural composition comprises sodium glucoheptonate. Enhancer Compound

[0063] In some embodiments, the present disclosure provides a composition comprising a compound of Formula (I) having the structure:ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 (I), or a stereoisomerwherein: R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6- membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2.

[0064] In some embodiments, R is the sidechain of a proteogenic amino acid. In some embodiments, the sidechain is -CH3, -CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, - CH(CH3)CH2CH3, -CH2OH, -CH(OH)CH3, -(CH2)4NH2, -(CH2)3NH(C=N)NH2, -CH2COOH, -(CH2)2COOH, -CH2CONH2, -(CH2)2CONH2, -(CH2)2SCH3, -CH2SH, -CH2Ph, -CH2-(4- hydroxyphenyl), -CH2-(1H-imidazol-4-yl), or -CH2-(1H-indol-3-yl).

[0065] In some embodiments, R is the sidechain of a non-proteogenic amino acid. In some embodiments, the sidechain is -CH2NH2, -(CH2)2NH2, -(CH2)3NH2, -(CH2)2SeCH3, -CH2SeH, -CH2-(CO)-NH2, -(CH2)2-(CO)-NH2, -CH2CH2O-NH2, -CH2CH2Ph, -(CH2)3NH-(CO)-NH2, - oralkylene-CO-NH2, alkylene-NH(C=N)NH2, alkylene-SH, alkylene-S-alkyl, alkylene-phenyl, or alkylene-heteroaryl.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0067] In some embodiments, R is -CH3, -CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, - CH(CH3)CH2CH3, -CH2OH, -CH(OH)CH3, -CH2NH2, -(CH2)2NH2, -(CH2)3NH2, - (CH2)2SeCH3, -CH2SeH, -(CH2)4NH2, -(CH2)3NH(C=N)NH2, -CH2COOH, -(CH2)2COOH, - CH2CONH2, -(CH2)2CONH2, -CH2-(CO)-NH2, -(CH2)2-(CO)-NH2, -CH2CH2O-NH2, - (CH2)3NH-(CO)-NH2, -CH2CH(COOH)2, -(CH2)2SCH3, -CH2SH, -CH2Ph, -CH2CH2Ph, -CH2- ,R1is H.

[0069] In some embodiments, R and R1taken together with the atoms to which they are attached form a 5-membered heterocyclic ring. In some embodiments, the 5-membered ring is a pyrrolidinyl ring. In some embodiments, R and R1taken together with the atoms to which they are attached form a 6-membered heterocyclic ring. In some embodiments, the 6-membered ring is a piperidinyl or piperazinyl ring. In some embodiments, the 6-membered ring has the , wherein m is as defined herein.m is 0. In some embodiments, m is 1. In some embodiments, m is 2.

[0071] In some embodiments, when m is 2, R is H. In some embodiments, when m is 0, R is the sidechain of a proteogenic or non-proteogenic amino acid as defined herein.

[0072] In some embodiments, X is Na+and n is 1. In some embodiments, X is K+and n is 1. In some embodiments, X is Ca2+and n is 2.

[0073] In some embodiments, the compound disclosed herein has the structure of Formula (Ia):ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 , wherein R, X, and

[0074] The present disclosure also provides methods of preparing a compound of Formula (I) or Formula (Ia). In some embodiments, the method comprises reacting a glucoheptonate salt and an amino acid under acidic conditions and at a temperature greater than 40°C, e.g., according to the following reaction scheme:

[0075] In some embodiments, an agricultural composition herein comprises an enhancer compound according to Formula (I). In some embodiments, the enhancer compound increases the efficacy of the agricultural composition for promoting improved plant health and / or productivity. In some embodiments, the enhancer compound improves uptake or availability of nutrients comprised by the agricultural composition. Sugar and / or Molasses

[0076] In some embodiments, the present disclosure teaches an agricultural composition comprising a sugar and / or molasses. In some embodiments, the agricultural composition comprises sugar. In some embodiments, the agricultural composition comprises molasses. Thus, in some embodiments, the sugar is comprised within molasses.

[0077] Molasses is the by-product of beating sugarcane, grapes or sugar beets into sugar. The dark, rich, and somewhat sweet liquid is commonly used as a sweetener in baked goods, as a natural remedy for many ailments, and added to animal feed. Even though it is a by-product, molasses is full of vitamins and minerals, which can be beneficial for plant-growth.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0078] In some embodiments, the agricultural composition comprises blackstrap molasses. Blackstrap molasses is a by-product of sugar production. It contains sugar but also beneficial nutrients, including iron. Sugar production starts with boiling sugarcane juice to crystallize the sugar, which is then filtered to separate it from the juice. This leaves a thick, brown liquid called molasses.

[0079] Persons having skill in the art will be familiar with methods of making molasses, which are generally disclosed in multiple journals (see e.g., Olbrich, Hubert. "The molasses." Principles of sugar technology 3 (1963): 511-697.). Briefly, to produce molasses, sugarcane is harvested and stripped of leaves. Its juice is then extracted, usually by cutting, crushing or mashing. The juice is boiled to produce a concentrate and encourage sugar crystallization. The result of this first boiling is called first syrup ('A' Molasses) and has the highest sugar content. First syrup is usually referred to in the Southern United States as cane syrup rather than molasses. Second molasses ('B' Molasses) is produced by a second boiling and sugar extraction and has a slightly bitter taste. Boiling the sugar syrup a third time yields dark, viscous blackstrap molasses ('C' Molasses), known for its robust flavour. During this process, the majority of sucrose from the original juice is crystallized and removed. Therefore, unless otherwise specified, the term “molasses” may encompass A Molasses, B Molasses, C. Molasses, or combinations thereof.

[0080] In some embodiments, the composition comprises cane water. Cane water refers to the liquid extracted from sugarcane, typically obtained by pressing or crushing sugarcane stalks. In some embodiments, the composition comprises 1-50% w / w cane water. In some embodiments, the composition comprises 0.1-15% w / w cane water. Algae Extract

[0081] In some embodiments, the present disclosure teaches an agricultural composition comprising an algae extract. In some embodiments, the algae extract comprises microalgae. In some embodiments, the algae extract comprises macroalgae. In some embodiments, the algae is kelp. In some embodiments, the algae extract comprises an extract from an algae selected from the group consisting of Bull Kelp (Nereocystis luetkeana); Giant Kelp (Macrocystis pyrifera); Sea Palm (Postelsia palmaeformis); Grapestone or Turkish washcloth (Mastocarpus papillatus); Bladderwrack (Fucus distichus); Kombu (Laminaria setchellii); Wakame (Alaria marginata); Sea Cabbage or sweet kombu (Saccharina sessilis); Bladder Chain Kelp or sea fern (Stephanocystis osmundacea); Nori (Pyropia species); and Sea Lettuce (Ulva species). InATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 some embodiments, the algae extract comprises Ascophyllum nodosum and / or Ecklonia maxima.

[0082] In some embodiments, the algae is microalgae. Microalgae encompass a wide variety of microscopic photosynthetic organisms that thrive in aquatic environments. Some common examples of microalgae include diatoms, which are characterized by intricate silica shells and play a crucial role in phytoplankton communities. Chlamydomonas, a single-celled green alga, is known for its versatility and is often studied for its simple cellular structure. Euglena, another microalga, exhibits both plant-like and animal-like characteristics, possessing a flexible outer covering and a flagellum for movement. Cyanobacteria, although technically bacteria, are often referred to as blue-green algae due to their photosynthetic abilities. These microorganisms contribute to the aquatic ecosystem's primary production. Dinoflagellates, with their two flagella, are diverse microalgae found in various aquatic habitats, with some species responsible for bioluminescence or harmful algal blooms. In some embodiments, the algae extract is derived from any microalgae disclosed herein.

[0083] In some embodiments, the algae is macroalgae. Macroalgae, also known as seaweeds, are larger, multicellular algae that can be found in marine and freshwater environments. Brown algae, such as kelp, are among the most prominent macroalgae. Kelp forests, composed of large, brown kelp species, create complex underwater ecosystems and provide habitat for diverse marine life. Red algae, like coralline algae and dulse, are common macroalgae found in marine environments. Coralline algae contribute to reef structures and provide a hard substrate for other organisms. Dulse is a red alga consumed by humans in various cuisines. Green algae also include macroscopic forms, with examples such as Ulva, commonly known as sea lettuce. Ulva species form bright green, sheet-like structures in intertidal zones. Additionally, certain species of green and red macroalgae, like Gracilaria and Porphyra, are cultivated for commercial purposes, including use in food products and agar production. In some embodiments, the algae extract is derived from any macroalgae disclosed herein.

[0084] Persons having skill in the art will be familiar with the many methods available for making algae extracts, including maceration, digestion, decoction, infusion, percolation, soxhlet extraction, superficial extraction, ultrasound-assisted, and microwave-assisted extractions. Additional methods of extraction are discussed in later sections of this disclosure. Algae extracts are also commercially available, including at world wide web kelpak.com / eckloniamaxima.html.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0085] Ascophyllum nodosum

[0086] As noted above, in some embodiments, the algae extract comprises Ascophyllum nodosum. Ascophyllum nodosum is commonly known as rockweed, and is abundantly distributed throughout the northwest coast of Europe and the northeastern coast of North America (Moreira, R. et al., 2017, Aqueous extracts of Ascophyllum nodosum obtained by ultrasound-assisted extraction: effects of drying temperature of seaweed on the properties of extracts J. Appl. Phycol.29, 3191–3200).

[0087] Other publications reviewed the unique characteristics of A. nodosum as a prominent source for the production and synthesis of biostimulants (Craigie, J. S. (2011). Seaweed extract stimuli in plant science and agriculture. J. Appl. Phycol. 23, 371–393. doi: 10.1007 / s10811- 010-9560-4). One unique feature of A. nodosum is its mutualistic association with the fungal endophyte Mycosphaerella ascophylli (Craigie, J. S. (2011). Thus, in some embodiments, algae extracts further comprise endophyte extracts, which may confer some of the benefits associated with algae extracts. For example, results published in U.S. Patent No. 12 / 936,074, showed that M. ascophylli-derived fungal sterols present in the ethyl acetate extract of A. nodosum mitigated salinity stress in plants.

[0088] Commercially dried and milled, A. nodosum meal is reported to contain carbohydrate (44.7 ± 2.1%), ash (18.6 ± 0.9%), protein (5.2 ± 0.2%), lipids (3.0 ± 0.1%), phenolics (1.4 ± 0.2%), and other compounds (13.6%) (Moreira, R. et al. , J. Appl. Phycol.29, 3191–3200). In some embodiments, extracts from A. nodosum promote plant growth (Van Oosten, et al., 2017, Chem. Biol. Technol. Agric.4:5).

[0089] Ecklonia maxima

[0090] As noted above, in some embodiments, the algae extract comprises Ecklonia maxima. Ecklonia maxima is a brown algae seaweed typically found along the southern Atlantic coast of Africa, from the very south of South Africa to northern Namibia (Miceli, A. et al., Horticulturae 2021, 7, 440). In these areas the species dominates the shallow, temperate water, reaching a depth of up to 8 metres (26 ft) in the offshore kelp forests. The kelp anchors itself by attaching itself to a rock or other kelp via its holdfast. From this root-like structure a single long stipe rises to the surface waters, where a large pneumatocyst keeps a tangle of blades at the surface to aid photosynthesis. Ecklonia maxima has been harvested over the last years and used to produce alginate, animal feed, fertilizers, and plant biostimulants. is a species of kelp native to the southern oceans.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Micronutrients

[0091] In some embodiments, an agricultural composition of the disclosure comprises a micronutrient. In some embodiments, the composition comprises one or more of: Boron (B), Chlorine (Cl), Copper (Cu), Iron (Fe), Manganese (Mn), Molybdenum (Mo), Nickel (Ni), and Zinc (Zn). In some embodiments, a composition herein comprises zinc, magnesium, boron, iron, and manganese.

[0092] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w boron.

[0093] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w chlorine.

[0094] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w copper.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0095] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w iron.

[0096] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w manganese.

[0097] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w molybdenum.

[0098] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w nickel.

[0099] In some embodiments the agricultural composition comprises about 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, or 5% w / w zinc.

[0100] In some embodiments, the agricultural composition comprises about 0.0001%-0.01% w / w of a micronutrient listed here. Macronutrient

[0101] In some embodiments, an agricultural composition of the disclosure comprises a macronutrient. In some embodiments, the composition comprises one or more of: Nitrogen (N), Phosphorous (P), Potassium (K), Calcium (Ca), Magnesium (Mg), and Sulphur (S).

[0102] In some embodiments, a composition herein comprises nitrogen. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w nitrogen. In some embodiments, a composition herein comprises 1-15% w / w nitrogen.

[0103] In some embodiments, a composition herein comprises phosphorus. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w phosphorus. In some embodiments, a composition herein comprises 0.1-10% w / w phosphorus.

[0104] In some embodiments, a composition herein comprises potassium. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w potassium. In some embodiments, a composition herein comprises 5-50% w / w potassium.

[0105] In some embodiments, a composition herein comprises calcium. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w calcium. In some embodiments, a composition herein comprises 0.1-10% w / w calcium.

[0106] In some embodiments, a composition herein comprises magnesium. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w magnesium. In some embodiments, a composition herein comprises 0.0001-1% w / w magnesium.

[0107] In some embodiments, a composition herein comprises sulphur. In some embodiments, a composition herein comprises 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% w / w sulphur. In some embodiments, a composition herein comprises 0.1-10% w / w sulphur. Formulation

[0108] The present disclosure teaches various agricultural composition recipes. In some embodiments, the agricultural composition comprises a) proteogenic amino acids; b) non- proteogenic amino acids, e.g., γ -aminobutyric acid (GABA); c) desert plant extract and d) chelating agent. In some embodiments, the composition comprises algae extract. In some embodiments, the composition comprises sugar.

[0109] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% desert plant extract by weight of the composition, including all values and subranges therebetween.

[0110] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% non-proteogenic amino acid, e.g., γ -aminobutyric acid (GABA), by weight of the composition, including all values and subranges therebetween.

[0111] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% algae extract by weight of the composition, including all values and subranges therebetween.

[0112] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% sugar (e.g., cane water, molasses, or blackstrap molasses) by weight of the composition, including all values and subranges therebetween.

[0113] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% proteogenic amino acids (e.g., protein hydrolysates or corn steep) by weight of the composition, including all values and subranges therebetween.

[0114] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% corn steep by weight of the composition, including all values and subranges therebetween.

[0115] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% protein hydrolysates (e.g., from soy) by weight of the composition, including all values and subranges therebetween.

[0116] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 69%, or 70% chelating agent by weight of the composition, including all values and subranges therebetween.

[0117] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% Sodium Glucoheptonate by weight of the composition, including all values and subranges therebetween.

[0118] In some embodiments the agricultural composition comprises about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% Citric Acid (Anhydrous) by weight of the composition, including all values and subranges therebetween.

[0119] In some embodiments, the agricultural composition of the present disclosure comprises other agriculturally acceptable additives, auxiliaries, and / or excipients. Additional components may act to improve the stability of the composition, improve the homogeneity of the composition, improve the function of the composition in planta, or provide other qualities to the composition and / or to the methodology of the present disclosure.

[0120] For example, in some embodiments, the agricultural composition of the present disclosure comprises a surfactant. By the term "surfactant" it is understood that wetting agents, surface-active agents or surfactants, dispersing agents, suspending agents, emulsifying agents, and combinations thereof, are included therein. Ionic and non-ionic surface-active agents can be used.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0121] Examples of non-ionic surface-active agents include, but are not limited to, alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof, allinol, nonoxynol, octoxynol, oxycastrol, oxysorbic (for example, polyoxyethylated sorbitol fatty-acid esters, thalestol, and polyethylene glycol octylphenol ether (TRITON®). In some embodiments, the surfactant is polysorbate-20.

[0122] Examples of ionic surfactants for use with the compositions described herein may include anionic surfac-tants such as alkali, alkaline earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates, and mixtures thereof. Examples of sulfonates are alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates, lignin sul-fonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphe-nols, sulfonates of condensed naphthalenes, sulfonates of dodecyl- and tridecylbenzenes, sulfonates of naphthalenes and alkylnaphthalenes, sulfosuccinates or sulfosuccina-mates. Examples of sulfates are sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl car-boxylates, and carboxylated alcohol or alkylphenol ethoxy-lates.

[0123] Persons having skill in the art will be able to formulate the compositions of the present disclosure with appropriate surfactants to allow for plant applications. In some embodiments, the amount of surfactant used is the minimum amount required to get the compound into solution / emulsion, and will generally be 0.1% to 5% by weight.

[0124] In some embodiments, the agricultural composition of the present disclosure further comprises amino acids, minerals, salts, solvents, stabilizers, hormones, enzymes, vitamins, chitin, chitosan, carboxylic acids, carboxylic acid derivatives, linoleic acid and other fatty acids, volatile organic compounds (VOCs), microbial consortia or isolates, bioregulators, biostimulants, and other additives known in the art to elicit a biological, biochemical, physiological, and / or physiochemical response from the plant, or to stabilize the composition, or to elicit specific metabolite production in the plant.

[0125] In some embodiments, the agricultural composition of the present disclosure comprises other active or inactive ingredients. In some embodiments, the composition includes at least one fungicide. Example fungicides include, but are not limited to, azoxystrobin, bifujunzhi, coumethoxystrobin, coumoxystrobin; dimoxystrobin, enes-troburin, enoxastrobin, fenaminstrobin, fenoxystrobin, flufenoxystrobin, fluoxastrobin, jiaxiangjunzhi, kresoxim-ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 methyl, mandestrobin, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraox-ystrobin, triclopyricarb, trifloxystrobin, methyl 2-[2-(2,5-dimethy lphenyloxymethy l)pheny l]-3-methoxyacry late, pyribencarb, triclopyricarb / chlorodincarb, famoxadon, fena-midon, cyazofamid, amisulbrom, benodanil, bixafen, boscalid, carboxin, fenfuram, fluopyram, flutolanil, fluxapy-roxad, furametpyr, isopyrazam, mepronil, oxycarboxin, pen-flufen, penthiopyrad, sedaxane, tecloftalam, thifluzamide, N-( 4 '- trifluoromethy lthio-bipheny 1-2-yl )-3-difluoromethy 1-1-methy l-1 H-pyrazole-4- carboxamide, N-(2-(1,3,3-trimeth-ylbutyl)phenyl)-1,3-dimethyl-5-fluoro-l H-pyrazole-4- car-boxamide, N-[9-( dichloromethylene )-1,2,3,4-tetrahydro-l, 4-methanonaphthalen-5-yl]-3- ( difluoromethyl)-1-methyl- H-pyrazole-4-carboxamide, diflumetorim, binapacryl, dinobuton, dinocap, meptyl-dinocap, fluazinam, ferimzone, ametoctradin, silthiofam, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole; fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, oxpoconazole, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, imazalil, pefurazoate, prochloraz, triflumizole, pyrimidines, fenari-mol, nuarimol, pyrifenox, triforine, aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph, fenpropidin, piperalin, spiroxamine, fenhexamid, benalaxyl, benal- axyl-M, kiralaxyl; metalaxyl, metalaxyl-M (mefenoxam), ofurace; oxadixyl, hymexazole, octhilinone, oxolinic acid, bupirimate, benomyl, carbendazim, fuberidazole, thiaben-dazole, thiophanate-methyl, 5-chloro-7-( 4-methyl-piperi-din-1-yl)-6- (2,4,6-trifluorophenyl)-[1,2,4 ]triazolo[l ,5-a ]pyrimidine, diethofencarb, ethaboxam, pencycuron, fluopicolid, zoxainid, metrafenon, pyriofenon, cyprodinil, mepanipyrim, pyrimethanil, fluoroimide, iprodione, procymidone, vinclozolin fenpiclonil, fludioxonil, quinoxyfen, edifenphos, iprobenfos, pyrazophos, isoprothiolane, dicloran, quintozene, tecnazene, tolclofos-methyl, biphenyl, chloroneb, etridiazole, dimethomorph, flumorph, mandipropamid, pyrimorph, benthiavalicarb, iprovalicarb, valifenal-ate and 4-fluorophenyl N- (1-(1-( 4-cyanophenyl)ethanesul-fonyl)but-2-yl)carbamate, propamocarb, propamocarb hydrochloride, ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, ziram, anilazine, chlorothalonil, captafol, captan, folpet, dichlofluanid, dichlorophen, flusulfamide, hexachlorobenzene, pentachlorophenol, phthalid, tolylfluanid, N-( 4-chloro-2-nitrophenyl)-N- ethyl-4-methyl-benzenesulfonamide, guanidine, dithianon, validamycin, polyoxin B, pyroquilon, tricyclazole, carpropamid, dicyclomet, fenoxanil, and mixtures thereof.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0126] In some embodiments, the agricultural composition of the present disclosure comprises at least one growth regulator. In some aspects, the growth regulator an ethylene inhibitor. In some aspects, the growth regulator is 1-methylcyclopropene (1-MCP).

[0127] In some embodiments, the agricultural composition may be prepared as a concentrate for industrial application and further dilution or as a fully diluted ready-to-apply composition. The agricultural composition disclosed herein include liquid and / or dry forms and include dry stock components that are added to water or other liquids prior to application to the plant in an aqueous form. Liquid compositions include aqueous, polar, or non-polar solutions. The compositions may comprise an oil-in-water emulsion or a water-in-oil emulsion. In some embodiments, the agricultural composition is diluted. In some embodiments the agricultural composition is concentrated. In some embodiments the composition is aqueous. Modes of Extraction

[0128] Various embodiments of this disclosure comprise one or more biological extract. Persons having skill in the art will be well-versed in available techniques for producing extracts (Front. Plant Sci., 29 May 2019 Sec. Plant Nutrition Volume 10 – 2019). A non-limiting list of known extraction techniques is discussed for convenience.

[0129] Water-Based Extractions

[0130] The name of this extraction method is indicative of the process: biostimulatory compounds are harvested by blending and hydrating biological material (e.g., seaweed meal or desert plant biomass) in the presence of water. In this technique, the solid residues are separated using different filtration methods based on the end use of the resulting ingredient.

[0131] Acid Hydrolysis

[0132] In this method, freshly chopped biomass (e.g., e.g., seaweed meal or desert plant biomass) is treated with sulfuric acid or hydrochloric acid at 40–50°C for 30 min. In some embodiments, acid hydrolysis

[0133] Alkaline Hydrolysis

[0134] Alkaline hydrolysis is perhaps the most widely used industrial hydrolysis process for the production of biomass extracts (e.g., seaweed meal or desert plant biomass). This method involves extracting biomass in NaOH or KOH solutions, at “relatively low” temperatures, between 70 and 100°C. This process breaks down complex polysaccharides into smaller, lower-molecular-weight oligomers.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0135] Microwave-Assisted Extraction

[0136] Microwave-assisted extraction (MAE) is an eco-friendly extraction method for the manufacture of extracts from biomass, (e.g., seaweed meal or desert plant biomass), as compared to other solvent-based extraction procedures. In this method, slurry prepared from biomass, in either water or microwave-supported solvent, is heated by microwave energy to extract bioactive compounds (Flórez-Fernández, N., Torres, M. D., González-Muñoz, M. J., and Domínguez, H. (2018). Potential of intensification techniques for the extraction and depolymerization of fucoidan. Algal Res.30, 128–148).

[0137] Ultrasound-Assisted Extraction

[0138] Ultrasound-assisted extraction (UAE) is another eco-friendly method for obtaining extracts from biomass. Ultrasound waves are high frequency (greater than 20 kHz), which transmit through solid, liquid, and gas media by rarefactions (largest distance between wave particles) and compression (smallest distance between wave particles) (Kadam et al. (2013). Application of novel extraction technologies for bioactives from marine algae. J. Agric. Food Chem. 61, 4667–4675). When cavitation (i.e., the formation and eventual implosion of empty spaces or bubbles) occurs near seaweed cell walls, the transfer of compounds from the cell to the solvent is facilitated following cellular breakdown (Kadam et al.2013).

[0139] Enzyme-Assisted Extraction

[0140] Enzyme-assisted extraction (E-AE) is another eco-friendly and efficient extraction method for producing biomass extracts (Kadam et al. 2013, J. Agric. Food Chem. 61, 4667– 4675). The efficiency of the extraction lies in the enzymatic degradation of the complex molecules present in the biomass cell walls (e.g., of desert plants or kelp) (Wijesinghe, W. A., and Jeon, Y. J. (2012). Enzyme-assistant extraction (EAE) of bioactive components: a useful approach for recovery of industrially important metabolites fromalgae: a review. Fitoterapia 83, 6–12). Persons having skill in the art are equipped to select enzymes based on the desired extracts. Various carbohydrate-degrading enzymes and proteases such as Viscozyme, Cellucast, Termamyl, Ultraflo, carrageenanase, agarase, xylanase, Kojizyme, Neutrase, Alcalase, and Umamizyme are commonly used for the extraction of bioactive compounds from plant material, including seaweeds (Wijesinghe, W. A., and Jeon, Y. J. (2012). Fitoterapia 83, 6–12). The application of hydrolytic enzymes converts the water-insoluble chemical components of selected seaweed biomass to water-soluble products, thus eliminating the problem of water solubility of bioactive compounds. E-AE extracts have been produced in aATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 variety of seaweeds, including Ecklonia cava, Ishige okamurae, Sargassum fulvellum, S. horneri, S. coreanum, S. thunbergii, and Scytosiphon lomentaria.

[0141] Super-Critical Fluid Extraction

[0142] The super-critical fluid extraction (SFE) method is yet another eco-friendly method of bioactive extraction from biomass. (Michalak et al.2016, Supercritical fluid extraction of algae enhances levels of biologically active compounds promoting plant growth. Eur. J. Phycol.51, 1–10). This method protects the biomass against thermal or biochemical degradation of the bioactive compounds. Bioactive compounds within the biomass are extracted in the presence of super-critical organic solvents (often CO2, based on its critical conditions, availability, and high diffusivity when mixed with ethanol). The higher penetration of the solvent into the biomass during SFE results in better mass transfer between solvent phases.

[0143] Pressurized Liquid Extraction

[0144] Pressurized liquid extraction (PLE) was first reported by Richter et al. (1996). Accelerated solvent extraction: a technique for sample preparation. Anal. Chem. 68, 1033– 1039. In this method, extraction was carried out under high pressure (3.5–20 MPa) and temperature (50–200°C). The high pressure elevated the temperature of solvents above their boiling point, facilitating bioactive compound extraction by increasing the solubility of complex molecules and increasing mass transfer rate (Chojnacka et al. 2015, Algae as production systems of bioactive compounds. Eng. Life Sci. 15, 160–176.). PLE has been applied to produce a variety of extracts, including from A. nodosum, Pelvetia canaliculata, Fucus spiralis, and Ulva intestinalis. Methods of Application

[0145] In some embodiments, the methods and compositions disclosed herein can be applied to seed, seedling, clone stock, vegetative tissues, root tissues, leaves, flowering tissues, and mature plant parts, and / or the locus where plants are grown, such as soil or other growth media. In some embodiments, the agricultural composition of the present disclosure may be applied in liquid or dry form, using a foliar spray, a root drench or a gas to subterranean plant cells and / or aerial plant cells. In some embodiments, the agricultural composition of the present disclosure may be applied to the soil, to the plant, or to both the soil and the plant. In some embodiments, the agricultural composition of the present disclosure may be applied to plant parts using methods known in the art, such as foliar spray, atomization, fumigation, or chemigation. In some embodiments, the may be applied to the soil using methods known in theATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 art such as irrigation, chemigation, fertigation, or injection. In some embodiments, the agricultural composition of the present disclosure may be applied to a soil or a water or a carbon dioxide or a composition source, including hydroponic and aeroponic and carbon dioxide injection systems, which is delivered to the plant in a liquid, dry, or gaseous form. In some embodiments, the plant may be grown indoors or outdoors, in a controlled or uncontrolled environment, in fields or in containers. The plant may be grown in soil-based media, soil-less media, or a media containing both soil-less and soil-based components. The plant may be grown in coco, rockwool, peat moss, or other acceptable medias well-known in the art. The plant may be grown with organic (Carbon-based), inorganic (synthetic), or a combination of both, compositions, amendments, adjuvants, pesticides, and supplements.

[0146] In some embodiments the agricultural composition of the present disclosure is applied to immature plants, seeds, or seedlings. In some embodiments, the agricultural composition of the present disclosure is applied to mature plants and / or plants in the reproductive stages. In some embodiments, the agricultural composition of the present disclosure is applied before harvest. In some embodiments, the agricultural composition of the present disclosure is applied between 24 and 72 hours before harvest. When agricultural composition of the present disclosure is applied to growing plant parts or flowers, the same, or a different composition may be applied at a later stage of growth, or before harvest.

[0147] In some embodiments, the agricultural composition of the present disclosure is used independently or as a mixture to alter the production of valuable primary and / or secondary metabolites by contacting some part of the plant or its environment at one or more distinct timepoints throughout the plant's lifecycle. The agricultural composition of the present disclosure may be applied once or more about: every day, every 2 days, every 3 days, every 4 days, every 5 days, every 6 days, every 7 days, every 8 days, every 9 days, every 10 days, every 11 days, every 12 days, every 13 days, every 14 days, every 15 days, every 16 days, every 17 days, every 18 days, every 19 days, every 20 days, every 21 days, every 22 days, every 23 days, every 24 days, every 25 days, every 26 days, every 27 days, every 28 days, every 29 days, every 30 days, every 31 days, every 32 days, every 33 days, every 34 days, every 35 days, every 36 days, every 37 days, every 38 days, every 39 days, every 40 days, every 41 days, every 42 days, every 43 days, every 44 days, every 45 days, every 46 days, every 47 days, every 48 days, every 49 days, every 50 days, every 51 days, every 52 days, every 53 days, every 54 days, every 55 days, every 56 days, every 57 days, every 58 days, every 59 days, every 60 days, every 61 days, every 62 days, every 63 days, every 64 days, every 65 days,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 every 66 days, every 67 days, every 68 days, every 69 days, every 70 days, every 71 days, every 72 days, every 73 days, every 74 days, every 75 days, every 76 days, every 77 days, every 78 days, every 79 days, every 80 days, every 81 days, every 82 days, every 83 days, every 84 days, every 85 days, every 86 days, every 87 days, every 88 days, every 89 days, every 90 days, every 91 days, every 92 days, every 93 days, every 94 days, every 95 days, every 96 days, every 97 days, every 98 days, every 99 days, every 100 days, every 101 days, every 102 days, every 103 days, every 104 days, every 105 days, every 106 days, every 107 days, every 108 days, every 109 days, every 110 days, or any combination of those days.

[0148] In some embodiments, the agricultural composition of the present disclosure may be applied only once during the entire plant life cycle, for example, at pre-veraison stage (berry development phase), or veraison stage (berry ripening phase).

[0149] In some embodiments, the agricultural composition of the present disclosure is applied prior to veraison. In some embodiments, the agricultural composition of the present disclosure is applied at or after veraison. In some embodiments, the agricultural composition of the present disclosure is applied between 72 and 24 hours prior to harvest. In some embodiments, the agricultural composition of the present disclosure is applied more than once during the plant lifecycle. In some embodiments, the agricultural composition of the present disclosure is applied every 3 to 10 days.

[0150] The effect on plants of the disclosed methods and compositions can be observed both genetically and chemically by any or all of the well-known analysis techniques including genomics, transcriptomics, proteomics, and metabolomics. The effect of different treatments on primary and secondary metabolite production can influence the taste, smell, appearance, effect, quality, yield, stress tolerance, and / or productivity of the living plant and its harvestable plant parts.

[0151] The methods of the present disclosure may be used on any host plant. In some embodiments, the host plant is an agricultural crop. Agricultural crops include agronomic crops, horticultural crops, and ornamental plants. In some embodiments, a method of the present disclosure is employed on an agronomical crop selected from the list consisting of wheat, rice, corn, soybean, alfalfa, forage crops, beans, sugar beets, canola, and cotton. In some embodiments, a method of the disclosure is employed on a horticultural crop selected from the list consisting of vegetables, fruits, flowers, ornamentals, and lawn grasses. In someATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 embodiments, a method of the disclosure is employed on an ornamental plant selected from the list consisting of flowers, shrubs, grasses, and trees.

[0152] Host plants include both monocots and dicots. In some embodiments, the methods of the disclosure are employed on monocots, such as agapanthus, asparagus, bamboo, bananas, corn, daffodils, garlic, ginger, grass, lilies, onions, orchids, rice, sugarcane, tulips, and wheat. In some embodiments, the methods of the disclosure are employed on dicots, such as apples, beans, broccoli, carrots, cauliflower, cosmos, daisies, peaches, peppers, potatoes, roses, sweet pea, and tomatoes. In some embodiments, the agricultural crop is a food crops, feed crop, cereal crop, oil seed crop, pulse, fiber crop, sugar crop, forage crop, medicinal crop, root crop, tuber crop, vegetable crop, fruit crop, or garden crop.

[0153] Compositions of the present invention may be applied to any plant or plant propagation material that may benefit from improved growth including agricultural crops, annual grasses, trees, shrubs, ornamental flowers and the like.

[0154] In some embodiments, the agricultural crop is selected from cereals, plantation crops, groundnut crops, grams, pulses, vegetables, fruits, proteaginous crops, citrus crops, berry crops, melon crops, vine crops. In some embodiments, the agricultural crop is selected from the list consisting of apple, barley, sunflower, plum, rice, paddy rice, agave, strawberry, watermelon, coffee, tomato, lentil, pea, chickpea, potato, cotton, sugarcane, wheat, banana, soybean, corn, sorghum, onion, carrot, bean, zucchini, lettuce, chicory, fennel, sweet pepper, pear, peach, cherry, kiwifruit, soft wheat, durum wheat, grapevine, table grape, olive, almond, hazelnut, cotton, canola, and maize. EXAMPLES Example 1: Manufacture of illustrative agricultural compositions of the disclosure. Materials and Methods

[0155] In one illustrative embodiment of the disclosure, 648 g water is added to a 1 L vessel, followed by desert plant extract comprising 25 g of yucca extract powder and 2 g of Lechuguilla liquid extract, which are then mixed until fully dissolved. Next, proteogenic amino acids in the form of 50 g of glutamic acid powder and 50 g of proline powder are added into the vessel and mixed until fully dissolved. Non-proteogenic amino acids in the form of 125 g of pipecolic acid powder are then added and mixed until fully dissolved. Finally, a chelating agent in the form of 200 g of a 50% sodium glucoheptonate solution is added and mixed until fully incorporated.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0156] In one illustrative embodiment of the disclosure, 562 g water is added to a 1 L vessel, followed by desert plant extract comprising 10 g of yucca extract powder and 3 g of tarbush liquid extract, which are then mixed until fully dissolved. Next, proteogenic amino acids in the form of 50 g of aspartic acid powder and 50 g of proline powder are added into the vessel and mixed until fully dissolved. Non-proteogenic amino acids in the form of 25 g of GABA and 100 g of ornithine are then added and mixed until fully dissolved. Finally, a chelating agent in the form of 200 g of a 50% sodium glucoheptonate solution is added and mixed until fully incorporated.

[0157] In one illustrative embodiment of the disclosure, 548 g water is added to a 1 L vessel, followed by desert plant extract comprising 25 g of yucca extract powder and 2 g of desert lily liquid extract, which are then mixed until fully dissolved. Next, proteogenic amino acids in the form of 50 g of lysine powder and 50 g of proline powder are added into the vessel and mixed until fully dissolved. Non-proteogenic amino acids in the form of 125 g of pipecolic acid powder are then added and mixed until fully dissolved. Finally, a chelating agent in the form of 200 g of a 50% sodium glucoheptonate solution is added and mixed until fully incorporated. Results

[0158] The combination of proteogenic amino acids, non-proteogenic amino acids, desert plant extract and sodium glucoheptonate results in increased uptake in plant nutrients and increased resistance to plant stressors such as heat and drought compared to using these components alone. Example 2: Illustrative enhancer compound comprised by agricultural compositions of the disclosure. Materials and Methods

[0159] In some embodiments, an agricultural composition of the disclosure comprises a compound according to Formula (I) having the structure: , or a stereoisomerwherein: R is H or a sidechain of an amino acid;ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6- membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2.

[0160] In this Example, compounds according to Formula (I) or Formula (Ia) are produced by reacting a glucoheptonate salt and an amino acid under acidic conditions and at a temperature greater than 40°C, e.g., according to the following reaction scheme:Example 3: Manufacture of an illustrative agricultural composition of the disclosure. Materials and Methods

[0161] An agricultural composition was produced comprising the following ingredients: Desert Plant Extract – 1-20%; Non-proteogenic amino acid in the form of Γ-aminobutyric acid (GABA) – 0.25-15%; Algae extract in the form of Kelp Extract Powder (Ascophyllum nodosum and / or Ecklonia maxima) – 0.1-5%; Sugar, provided in the form of Blackstrap Molasses – 1-50%; Proteogenic amino acids, provided in the form of Corn Steep or Soy Protein Hydrolysates – 0.5-10%; Chelating agents, provided in the form of Sodium Glucoheptonate Solution – 1-20% and Citric Acid (Anhydrous) – 0.01-5%. Example 4: Illustrative application of an enhanced agricultural composition on cotton plants. Materials and Methods

[0162] An agricultural composition of the disclosure was prepared according to Example 3 and applied to cotton plants. Plants treated with the agricultural composition of the disclosure were compared to cotton plants receiving the grower standard fertilizer (Control) and to cotton plants receiving application of a commercially available foliar nitrogen-phosphate (20 / 20 / 0) product.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of the disclosure and the commercial product were each applied at a rate of 16 oz / acre twice over the growing period, for a total application of 32 oz / acre.

[0163] Triplicate plants from each treatment condition were collected. Number of bolls and total boll weight were measured and averaged among the three plants in each treatment group. Results

[0164] Application of the agricultural composition resulted in more than double the number of cotton bolls, and nearly double the total boll weight, compared to application of the grower standard fertilizer. The agricultural composition also outperformed the commercially available product in both boll count and total boll weight. See Table 2 and FIG.1A-1B. Table 2: Cotton boll yield. Fertilizer Boll Count Total Boll Weight (Oz) Grower Standard 30 1021Example 5: Illustrative application of an enhancer composition on soybean plants. Materials and Methods

[0165] An agricultural composition of the disclosure was prepared according to Example 3 and applied to soybean plants. Plants treated with the agricultural composition of the disclosure were compared to soybean plants receiving the grower standard fertilizer and to soybean plants receiving application of a commercially available foliar nitrogen-phosphate (20 / 20 / 0) product. The agricultural composition of the disclosure and the commercial product were each applied at a rate of 16 oz / acre or 32 oz / acre twice over the growing period, for a total application of 32 oz / acre or 64 oz / acre. Applications occurred during V4-V5 and R1-R3 stages.

[0166] Triplicate plants from each treatment condition were collected at R5 stage. Number of soybean pods, seeds per pod, total pod weight, and total root mass were measured and averaged among the three plants in each treatment group. Results

[0167] Application of the agricultural composition resulted in a marked increase in total pods, seeds / pod, total pod weight, and total root mass compared to the grower standard or the commercial product at either application rate. See Table 3 and FIG.2A-2D.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Table 3: Soybean growth and yield. Fertilizer Total Pods Pods Pods Pods Total Total Pods w / 1 w / 2 w / 3 w / 4 Pod Wt. Root z)Example 6: Manufacture of an agricultural composition of the disclosure. Materials and Methods

[0168] An agricultural composition was produced comprising the following ingredients: Desert Plant Extract – 0.1-10% w / w; Proteogenic and non-proteogenic amino acid mixture including GABA – 0.5-15% w / w; Algae extract in the form of Kelp Powder – 0.1-5% w / w; Cane Water (as a source of sugar) – 0.1-20% w / w; Potassium, in the form of potassium acetate – 10-40% w / w; Nitrogen, in the form of urea – 0.5-15% w / w; Micronutrient blend, 0.1-5% w / w; and 30-70% w / w water. Example 7: Application of enhanced agricultural composition on cotton plants increases total boll count and total boll weight. Materials and Methods

[0169] An agricultural composition of the disclosure was prepared according to Example 6 and applied to cotton plants to determine effects on yield (total cotton boll weight in ounces). Cotton plants treated with the agricultural composition of the disclosure were compared to untreated plants (Control) in two separate trials. Both treatment groups received grower standard fertilizer. In each trial, yields were compared between cotton plants in triplicate (n=3) from each experimental group. Cotton plants were analyzed for total boll count and total boll weight. In the first trial, the number of cotton boll squares was also documented.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0170] Trial #1: In the first trial, the agricultural composition of the disclosure was applied twice by foliar application at a rate of 16 oz / acre. Application occurred during 3rdleaf and 1stbloom stages of the cotton life cycle.

[0171] Trial #2: In the second trial, the agricultural composition of the disclosure was applied by foliar application at a rate of 16 oz / acre. Application occurred during the 5thleaf stage of the cotton life cycle. Results

[0172] Results are shown in Table 4 and Table 5, as well as FIG.3A-3D. In each trial, with comparison to the Control group, treatment with the agricultural composition of the disclosure increased yield by at least 20%. Application of the agricultural composition of the disclosure increased not only the number of cotton bolls per plant but also the total boll weight in both trials.

[0173] Trial #1: Treatment with the agricultural composition of the disclosure increased total boll weight by about 94% and boll count by 113%. Table 4: Cotton Trial #1 Results Treatment Application Boll Count Square Count Total Boll Weight (oz)

[0174] Trial #2: Treatment with the agricultural composition of the disclosure increased total boll weight by about 21%. Table 5: Cotton Trial #2 Results Treatment Application Boll Count Total BollATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Treatment Application Boll Count Total Boll Weight (oz) Exampe pp ca o o e a ce ag cu u a co pos o o pea u p a s increases yield, number of nuts per shell. Materials and Methods

[0175] An agricultural composition of the disclosure was prepared according to Example 6 and applied to peanut plants to determine effects on yield. Peanut plants were treated with an agricultural composition of the disclosure by foliar application at a rate of 16 oz / acre at both R2 (early-stage pod formation) and R4 (completion of pod development) stages of the peanut life cycle. Peanut yield, measured as total nut weight in ounces, was then compared in triplicate between plants receiving the agricultural composition of the disclosure and untreated plants (Control). All treatment groups received grower standard fertilizer. Results

[0176] Results are shown in Table 6 and FIG. 4A-4B. In comparison to the Control group, treatment with the agricultural composition of the disclosure increased total nut weight by about 24% (FIG. 4A). Additionally, application of the agricultural composition of the disclosure increased the number of 1-nut shells, 2-nut shells, and total number of nuts per plant (FIG.4B). Table 6: Peanut Trial Results Treatment Application 1-Nut 2-Nut Total Nuts Total Nut z)ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Example 9: Application of an enhanced agricultural composition on corn plants increases bushels per acre yield. Materials and Methods

[0177] An agricultural composition of the disclosure was prepared according to Example 6 and applied to corn plants to determine effects on yield. In two independent trials, corn plants were treated with the agricultural composition of the disclosure by foliar application at a rate of either 32 oz / acre or 64 oz / acre, applied at V6-VT stage. Corn yield, measured as bushels of corn per acre, was then compared in triplicate between plants receiving the agricultural composition of the disclosure and untreated (Control). All treatment groups received grower standard fertilizer. Results

[0178] Results are shown in Table 7 and FIG.5. In comparison to the Control group, treatment with the agricultural composition of the disclosure increased yield (number of bushels of corn per acre) by at least about 15%. Additionally, the number of corn kernels increased following foliar application of the agricultural composition of the disclosure (data not shown). Table 7: Corn Trial Results Treatment Application Yield (bushels / acre) Yield DifferenceExample 10: Application of an enhanced agricultural composition on soybean increased total pod yield. Materials and Methods

[0179] An agricultural composition of the disclosure was prepared according to Example 6 and applied to soybean plants to determine effects on yield. Soybean yield, determined by total number of soybean pods, was compared between plants treated with the agricultural composition of the disclosure and untreated plants (Control) in two independent trials. AllATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 treatment groups received grower standard fertilizer. Three plants were measured in each treatment group.

[0180] Trial #1: The agricultural composition of the disclosure was applied twice by foliar application at a rate of 16 oz / acre or 32 oz / acre. Application occurred at V3 (the vegetative stage characterized by the presence of three fully developed trifoliate leaves) and R1 (the reproductive stage characterized by the appearance of the first flower on the main stem) of the soybean life cycle. Root mass and number of beans per pod were also measured in this trial.

[0181] Trial #2: The agricultural composition of the disclosure was applied at a rate of 16 oz / acre at stage V3, at stage R1, or at both stages V3 and R1 of the soybean life cycle. Results

[0182] Trial #1: Results are shown in Table 8 and FIG.6A-6B. Relative to the Control group, two foliar applications of the agricultural composition of the disclosure at a rate of either 16 oz / acre or 32 oz / acre at both stage V3 and R1 increased total soybean yield significantly: the total number of soybeans was increased by about 11% for the 16 oz / acre treatment group and by about 56% for the 32 oz / acre treatment group. Significantly more 2 and 3-bean pods were collected from both treated groups compared to the control group Table 8: Soybean Trial #1 Results Treatment Application Total 1-Bean 2-Bean 3-Bean 4-Bean Total Total R t P d P d P d P d P d P d tATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005

[0183] Trial #2: Results are shown in Table 9 and FIG.7A-7B. Relative to the Control group, a single foliar application (16 oz / acre) of the agricultural composition of the disclosure at soybean life cycle stage V3 increased yield by about 31%. Application at the R1 stage increased yield by about 50% relative to the Control. Two foliar applications (16 oz / acre) at both V3 and R1 stages increased yield by about 44% in comparison to the Control group. Significantly more 2 and 3-bean pods were collected from both treated groups compared to the control group Table 9: Soybean Trial #2 Results Treatment Application 1-Bean 2-Bean 3-Bean 4-Bean Total Pods Pods Pods Pods PodsExample 11: Application of an enhanced agricultural composition on soybean increases yield and affects plant morphology. Materials and Methods

[0184] An agricultural composition of the disclosure was prepared according to Example 6 and applied to soybean plants to determine effects on yield. The composition was applied at 16 oz / acre at V3-V4 and again at R1. Soybean yield, determined by total number of soybean pods and total pod weight, was compared between plants treated with the agricultural composition of the disclosure and plants receiving only the grower standard fertilizer (Control) at multiple time points in two independent locations. Additionally, the morphological traits, such as height, lateral branches, blooms, fruiting sites, and inner-node length were measured in the treated and control groups. Five plants were measured and averaged per treatment condition at each time point in each location.

[0185] Location #1: Measurements were taken at R1 / beginning bloom (day 0), on day 7, on day 14, on day 21, on day 29, on day 45, on day 59, and on day 70. GDUs were recorded atATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 numerous time points in this location: 486 (day 0), 630 (day 7), 786.5 (day 14), 966 (day 21), 1192.5 (day 29), 1636.5 (day 45), and 2028 (day 59).

[0186] Location #2: Measurements were taken at R1 / beginning bloom (day 0), on day 13, on day 24, on day 52, and on day 71. Results

[0187] Location #1: Results for Location #1 are shown in Table 10 and FIG. 8A-8C. Application of the agricultural composition of the disclosure increased total pods, average pods per plant, and total pod weight compared to the control group. By day 59, there were also significantly more 2, 3, and 4-bean pods in the treated group compared to the control. FIG. 8A-8C show the results on day 59 for total pods (FIG. 8A), total pod weight (FIG. 8B), and the distribution of pod counts (FIG.8C) Table 10: Soybean Location #1 Results Characteristic Treatment Day Day Day Day Day Day Day Day 0 7 14 21 29 45 59 70ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Characteristic Treatment Day Day Day Day Day Day Day Day 0 7 14 21 29 45 59 70

[0188] Location #2: Results are shown in Table 11 and FIG.9A-9C. By day 71, application of the agricultural composition of the disclosure had resulted in significantly increased total pods, average pods per plant, total pod weight, and numbers of 3- and 4-bean pods. In this location, it was also observed that height, number of lateral branches, and number of fruiting sites were higher in the treated group compared to the control at all documented time points. FIG.9A-9C show the results on day 71 for total pods (FIG.9A), total pod weight (FIG.9B), and the distribution of pod counts (FIG.9C). Table 11: Soybean Location #2 Results Characteristic Treatment Day 0 Day 13 Day 24 Day 52 DayATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 Characteristic Treatment Day 0 Day 13 Day 24 Day 52 Day 71ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 INCORPORATION BY REFERENCE

[0189] All references, articles, publications, patents, patent publications, and patent applications cited herein are incorporated by reference in their entireties for all purposes. However, mention of any reference, article, publication, patent, patent publication, and patent application cited herein is not, and should not be taken as an acknowledgment or any form of suggestion that they constitute valid prior art or form part of the common general knowledge in any country in the world. NUMBERED EMBODIMENTS OF THE DISCLOSURE

[0190] Notwithstanding the appended claims, the disclosure sets forth the following numbered embodiments: 1. An agricultural composition comprising: a) a proteogenic amino acid; b) a non-proteogenic amino acid; c) a desert plant extract; and d) an algae extract. 2. The agricultural composition of embodiment 1, wherein the proteogenic amino acid is selected from the group consisting of: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine. 3. The agricultural composition of embodiment 1 or embodiment 2, wherein the proteogenic amino acid is at least partially comprised within a protein hydrolysate. 4. The agricultural composition of any one of embodiments 1-3, wherein the proteogenic amino acid is at least partially comprised within a soy protein hydrolysate. 5. The agricultural composition of any one of embodiments 1-4, wherein the proteogenic amino acid is at least partially comprised within corn steep. 6. The agricultural composition of any one of embodiments 1-5, wherein the composition comprises 0.1-30% w / w proteogenic amino acid. 7. The agricultural composition of any one of embodiments 1-5, wherein the composition comprises 0.1-10% w / w proteogenic amino acid.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of any one of embodiments 1-5, wherein the composition comprises 0.5-5% w / w proteogenic amino acid. The agricultural composition of any one of embodiments 1-8, wherein the non- proteogenic amino acid is selected from the group consisting of 2-aminoadipic acid, 2- aminobutyric acid, 2-aminopimelic acid, 3-aminobutyric acid, 3-aminopropionic acid, 4-aminobutyric acid, 6-aminocaproic acid, azetidine-2-carboxylic acid, beta-alanine, canaline, citrulline, gamma-aminobutyric acid (GABA), hydroxylysine, hydroxyproline, homocysteine, homoserine, isovaline, L-3,4-dihydroxyphenylalanine (L-DOPA), norleucine, norvaline, ornithine, pipecolic acid, sarcosine, selenocysteine, selenomethionine, and taurine. The agricultural composition of any one of embodiments 1-8, wherein the non- proteogenic amino acid is selected from the group consisting of γ-aminobutyric acid (GABA), selenomethionine or a derivative thereof, ornithine, selenocysteine, pipecolic acid or a derivative thereof, and L-3,4-dihydroxyphenylalanine (L-DOPA). The agricultural composition of any one of embodiments 1-8, wherein the non- proteogenic amino acid comprises γ-aminobutyric acid (GABA). The agricultural composition of any one of embodiments 1-11, wherein the agricultural composition comprises 0.01-20% w / w non-proteogenic amino acid. The agricultural composition of any one of embodiments 1-11, wherein the agricultural composition comprises 0.1-10% w / w non-proteogenic amino acid. The agricultural composition of any one of embodiments 1-13, wherein the desert plant extract comprises an extract from a plant of a genera selected from the group consisting of: Abronia, Acacia, Agave, Baileya, Berberis, Bursera, Carnegiea, Chilopsis, Dasylirion, Echinocactus, Encelia, Eremophila, Euphorbia, Ferocactus, Flourensia, Fouquieria, Hesperocallis, Larrea, Oenothera, Opuntia, Parkinsonia, Salvia, Stenocereus, Xerophyllum, and Yucca. The agricultural composition of any one of embodiments 1-14, wherein the desert plant extract comprises an extract from a plant of a species selected from the group consisting of: Acacia rigidula, Agave sp., Aloe dichotomum, Barrel cactus (Echinocactus sp. and Ferocactus sp.), Beargrass (Xerophyllum tenax), Berberis trifoliolata, Brittle bush (Encelia farinosa), Candelilla (Euphorbia antisyphilitica), Cholla Cactus (Opuntia), Creosote bush (Larrea tridentata), Desert lily (Hesperocallis undulata), DesertATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 marigold (Baileya spp.), Desert sage (Salvia dorrii), Desert spoon (Dasylirion wheeleri), Desert willow tree (Chilopsis linearis), Dune Primrose (Oenothera deltoides), Elephant tree (Bursera microphylla), Eremophila glabra, Euphorbia antisyphilitica, Ferocactus pilosus, Fishhook barrel cactus (Ferocactus wislizeni), Mahonia trifoliolata, Organ pipe cactus (Stenocereus thurberi), Ocotillo (Fouquieria splendens), Palm plants, Palo verde (Parkinsonia sp.), Prickly pear cactus (Opuntia sp.), Saguaro cactus (Carnegiea gigantea), Sand Verbena (Abronia villosa), Sotol (Dasylirion sp.), Tarbush (Flourensia cernua), and Yucca sp. The agricultural composition of any one of embodiments 1-15, wherein the desert plant extract comprises an extract from Desert lily (Hesperocallis undulata), Agave Lechuguilla, Yucca sp., or Tarbush (Flourensia cernua). The agricultural composition of any one of embodiments 1-16, wherein the desert plant extract comprises an extract from Yucca. The agricultural composition of any one of embodiments 1-17, wherein the composition comprises 0.01-20% w / w desert plant extract. The agricultural composition of any one of embodiments 1-17, wherein the composition comprises 0.1-10% w / w desert plant extract. The agricultural composition of any one of embodiments 1-17, wherein the composition comprises 0.5-5% w / w desert plant extract. The agricultural composition of any one of embodiments 1-20, wherein the composition comprises a chelating agent. The agricultural composition of any one of embodiments 1-21, wherein the composition comprises a chelating agent selected from citric acid and sodium glucoheptonate. The agricultural composition of any one of embodiments 1-22, wherein the composition comprises citric acid and sodium glucoheptonate. The agricultural composition of any one of embodiments 1-23, wherein the composition comprises sodium glucoheptonate. The agricultural composition of any one of embodiments 1-24, wherein the composition comprises 0.01-25% w / w chelating agent.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of any one of embodiments 1-24, wherein the composition comprises 0.01-5% w / w chelating agent. The agricultural composition of any one of embodiments 1-26, wherein the composition comprises an algae extract. The agricultural composition of any one of embodiments 1-27, wherein the composition comprises an algae extract derived from microalgae. The agricultural composition of any one of embodiments 1-28, wherein the composition comprises an algae extract derived from macroalgae. The agricultural composition of any one of embodiments 1-29, wherein the composition comprises an algae extract derived from kelp. The agricultural composition of any one of embodiments 1-30, wherein the composition comprises an algae extract, and wherein the algae extract comprises Ascophyllum nodosum and / or Ecklonia maxima extract. The agricultural composition of any one of embodiments 1-30, wherein the composition comprises 0.01-20% w / w algae extract. The agricultural composition of any one of embodiments 1-30, wherein the composition comprises 0.1-10% w / w algae extract. The agricultural composition of any one of embodiments 1-30, wherein the composition comprises 0.5-5% w / w algae extract. The agricultural composition of any one of embodiments 1-34, wherein the composition comprises sugar. The agricultural composition of any one of embodiments 1-35, wherein the composition comprises sugar, and wherein the sugar is at least partially comprised within molasses or cane water. The agricultural composition of any one of embodiments 1-36, wherein the composition comprises sugar, and wherein the sugar is at least partially comprised within cane water. The agricultural composition of any one of embodiments 1-37, wherein the composition comprises 0.1-50% w / w cane water. The agricultural composition of any one of embodiments 1-38, wherein the composition comprises 1-5% w / w cane water.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of any one of embodiments 1-39, wherein the composition comprises 0.5-50% w / w molasses. The agricultural composition of any one of embodiments 1-40, wherein the composition comprises 0.05-25% w / w sugar. The agricultural composition of any one of embodiments 1-41, wherein the composition comprises nitrogen, phosphorous, and / or potassium. The agricultural composition of any one of embodiments 1-42, wherein the composition comprises nitrogen and potassium. The agricultural composition of any one of embodiments 1-43, wherein the composition comprises 1-10% w / w nitrogen. The agricultural composition of any one of embodiments 1-44, wherein the composition comprises 5-20% w / w potassium. The agricultural composition of any one of embodiments 1-45, wherein the composition comprises a micronutrient or macronutrient selected from boron, calcium, chlorine, copper, iron, magnesium, manganese, molybdenum, sulfur, zinc, and nickel. The agricultural composition of any one of embodiments 1-46, wherein the composition comprises 0.1-100 ppm of a micronutrient or macronutrient selected from boron, calcium, chlorine, copper, iron, magnesium, manganese, molybdenum, sulfur, zinc, and nickel. The agricultural composition of any one of embodiments 1-47, wherein the composition comprises zinc, magnesium, boron, iron, and / or manganese. The agricultural composition of any one of embodiments 1-48, wherein the composition comprises a compound of Formula (I) having the structure: (I),or a wherein:ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2. The composition of any one of embodiments 1-49, wherein the composition comprises a compound of Formula (I), and wherein X is Na+and n is 1. The composition of any one of embodiments 1-49, wherein the composition comprises a compound of Formula (I), and wherein X is K+and n is 1. The composition of any one of embodiments 1-49, wherein the composition comprises a compound of Formula (I), and wherein X is Ca2+and n is 2. The composition of any one of embodiments 1-52, wherein the composition comprises a compound of Formula (I), and wherein R is the sidechain of a proteogenic amino acid. The composition of any one of embodiments 1-52, wherein the composition comprises a compound of Formula (I), wherein R is the sidechain of a proteogenic amino acid, and wherein the sidechain is -CH3, -CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, - CH(CH3)CH2CH3, -CH2OH, -CH(OH)CH3, -(CH2)4NH2, -(CH2)3NH(C=N)NH2, - CH2COOH, -(CH2)2COOH, -CH2CONH2, -(CH2)2CONH2, -(CH2)2SCH3, -CH2SH, - CH2Ph, -CH2-(4-hydroxyphenyl), -CH2-(1H-imidazol-4-yl), or -CH2-(1H-indol-3-yl). The composition of any one of embodiments 1-52, wherein the composition comprises a compound of Formula (I), and wherein R is the sidechain of a non-proteogenic amino acid. The composition of any one of embodiments 1-55, wherein the composition comprises a compound of Formula (I), and wherein R is -CH2NH2, -(CH2)2NH2, -(CH2)3NH2, - (CH2)2SeCH3, -CH2SeH, -CH2-(CO)-NH2, -(CH2)2-(CO)-NH2, -CH2CH2O-NH2, -ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 - - - ,a compound of Formula (I), and wherein R is alkyl, alkylene-OH, alkylene-COOH, alkylene-NH2, alkylene-CO-NH2, alkylene-NH(C=N)NH2, alkylene-SH, alkylene-S- alkyl, alkylene-phenyl, or alkylene-heteroaryl. The composition of any one of embodiments 1-57, wherein the composition comprises a compound of Formula (I), and wherein R1is H. The composition of any one of embodiments 1-58, wherein the composition comprises a compound of Formula (I), and wherein R and R1taken together with the atoms to which they are attached form a 6-membered ring, wherein the 6-membered ring has the . Theof embodiments 1-59, wherein the composition comprises a compound of Formula (I), and wherein m is 0. The composition of any one of embodiments 1-59, wherein the composition comprises a compound of Formula (I), and wherein R is H and m is 2. The composition of any one of embodiments 1-48, wherein the composition comprises a compound of Formula (I), and wherein the compound has the structure of Formula (Ia): ,ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 or a stereoisomer thereof. The composition of any one of embodiments 1-48, wherein the composition comprises a compound of Formula (I), and wherein the compound has the structure of Formula (Ib): (Ib). Thecomposition comprises a compound of Formula (I), and wherein the compound has the structure of Formula (I- 1): 1). An agriculturala) an amino acid mixture comprising proteogenic and non-proteogenic amino acids; b) γ -aminobutyric acid (GABA); c) a desert plant extract; d) an algae extract; e) and sugar. The agricultural composition of embodiment 65, wherein the agricultural composition comprises 0.1-10% w / w desert plant extract. The agricultural composition of embodiment 65 or 66, wherein the agricultural composition comprises 0.5-5% w / w desert plant extract. The agricultural composition of any one of embodiments 65-67, wherein the agricultural composition comprises 0.1-30% w / w amino acid mixture. The agricultural composition of any one of embodiments 65-67, wherein the agricultural composition comprises 0.1-10% w / w amino acid mixture.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of any one of embodiments 65-67, wherein the agricultural composition comprises 0.5-5% w / w amino acid mixture. The agricultural composition of any one of embodiments 65-70, wherein the agricultural composition comprises 0.01-15% w / w GABA. The agricultural composition of any one of embodiments 65-70, wherein the agricultural composition comprises 0.05-5% w / w GABA. The agricultural composition of any one of embodiments 65-72, wherein the agricultural composition comprises 0.1-10% w / w algae extract. The agricultural composition of any one of embodiments 65-72, wherein the agricultural composition comprises 0.5-5% w / w algae extract. The agricultural composition of any one of embodiments 65-74, wherein the agricultural composition comprises 0.05-25% w / w sugar. The agricultural composition of any one of embodiments 65-74, wherein the agricultural composition comprises 0.1-5% w / w sugar. The agricultural composition of any one of embodiments 65-76, wherein the composition comprises nitrogen, phosphorous, and / or potassium. The agricultural composition of any one of embodiments 65-77, wherein the composition comprises nitrogen and potassium. The agricultural composition of any one of embodiments 65-78, wherein the composition comprises 1-10% w / w nitrogen. The agricultural composition of any one of embodiments 65-79, wherein the composition comprises 5-20% w / w potassium. The agricultural composition of any one of embodiments 65-80, wherein the composition comprises a micronutrient or macronutrient, optionally selected from boron, calcium, chlorine, copper, iron, magnesium, manganese, molybdenum, sulfur, zinc, and nickel. The agricultural composition of any one of embodiments 65-81, wherein the composition comprises 0.1-100 ppm of a micronutrient or macronutrient, optionally selected from boron, calcium, chlorine, copper, iron, magnesium, manganese, molybdenum, sulfur, zinc, and nickel.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The agricultural composition of any one of embodiments 65-82, wherein the composition comprises a micronutrient or macronutrient selected from zinc, magnesium, boron, iron, and / or manganese. An agricultural composition comprising: a) 0.1-10% w / w desert plant extract; b) 0.05-5% w / w GABA; c) 0.1-5% w / w Kelp extract; d) 0.1-15% w / w sugar; e) 0.5-10% w / w protein hydrolysates; f) 10-50% w / w potassium acetate; and g) 0.5-20% w / w urea. A composition comprising: (a) a compound of Formula (I) having the structure: (I),wherein: R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2; and (b) one or more additives.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The composition of embodiment 85, wherein X is Na+and n is 1. The composition of embodiment 85, wherein X is K+and n is 1. The composition of embodiment 85, wherein X is Ca2+and n is 2. The composition of any one of embodiments 85-88, wherein R is the sidechain of a proteogenic amino acid. The composition of any one of embodiments 85-88, wherein R is the sidechain of a proteogenic amino acid , and the sidechain is -CH3, -CH2CH3, -CH(CH3)2, - CH2CH(CH3)2, -CH(CH3)CH2CH3, -CH2OH, -CH(OH)CH3, -(CH2)4NH2, - (CH2)3NH(C=N)NH2, -CH2COOH, -(CH2)2COOH, -CH2CONH2, -(CH2)2CONH2, - (CH2)2SCH3, -CH2SH, -CH2Ph, -CH2-(4-hydroxyphenyl), -CH2-(1H-imidazol-4-yl), or -CH2-(1H-indol-3-yl). The composition of any one of embodiments 85-88, wherein R is the sidechain of a non-proteogenic amino acid. The composition of any one of embodiments 85-88, wherein R is -CH2NH2, - (CH2)2NH2, -(CH2)3NH2, -(CH2)2SeCH3, -CH2SeH, -CH2-(CO)-NH2, -(CH2)2-(CO)- NH2, -CH2CH2O-NH2, -CH2CH2Ph, -(CH2)3NH-(CO)-NH2, -CH2CH(COOH)2, .OH, alkylene-COOH, alkylene-NH2, alkylene-CO-NH2, alkylene-NH(C=N)NH2, alkylene- SH, alkylene-S-alkyl, alkylene-phenyl, or alkylene-heteroaryl. The composition of any one of embodiments 85-93, wherein R1is H. The composition of any one of embodiments 85-94, wherein R and R1taken together with the atoms to which they are attached form a 6-membered ring, wherein the 6- membered ring has the .The composition of any one of 95, wherein m is 0.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The composition of any one of embodiments 85-88, wherein R is H and m is 2. The composition of any one of embodiments 85-97, wherein the compound has the structure of Formula (Ia): (Ia), or aThe composition of any one of embodiments 85-97, wherein the compound has the structure of Formula (Ib): . Thethe structure of Formula (I-1): .(I-1) having the structure: , the methodan amino acid (2) under acidic conditions and at a temperature greater that 40°C, according to the following reaction scheme:ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 .A method of growing a plant, said method comprising applying the composition of any one of embodiments 1-100 to a plant. The method of embodiment 103, wherein the plant displays a phenotype selected from the group consisting of: improved germination, improved stress tolerance, improved resistance to at least one disease, increased growth, increased fresh weight, increased dry weight, increased secondary metabolite content; increased flowering, increased fruit size, increased number of marketable fruit and increased harvest index. The method of embodiment 103 or 104, wherein the plant demonstrates increased yield in number of harvestable plant parts or total weight of harvestable plant parts. The method of any one of embodiments 103-105, wherein the plant has beans, and wherein the plant demonstrates a higher number of beans per pod compared to control. The method of any one of embodiments 103-106, wherein the agricultural composition is applied as a soil spray or soil drench. The method of any one of embodiments 103-107, wherein the agricultural composition is applied as a foliar spray. The method of any one of embodiments 103-108, wherein the agricultural composition is applied as a seed treatment or seed coating. The method of any one of embodiments 103-109, wherein the agricultural composition is applied as a granular fertilizer. The method of any one of embodiments 103-110, wherein the plant is a monocot or dicot.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 The method of any one of embodiments 103-110, wherein the plant is an agronomical crop. The method of any one of embodiments 103-110, wherein the plant is a cotton plant, peanut plant, soybean plant, or corn plant.

Claims

ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 CLAIMS 1. An agricultural composition comprising: a) a proteogenic amino acid; b) a non-proteogenic amino acid; c) a desert plant extract; and d) an algae extract.

2. The agricultural composition of claim 1, wherein the proteogenic amino acid is selected from the group consisting of: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, optionally wherein the proteogenic amino acid is at least partially comprised within a protein hydrolysate, optionally a soy protein hydrolysate or corn steep.

3. The agricultural composition of claim 1, wherein the non-proteogenic amino acid is selected from the group consisting of 2-aminoadipic acid, 2-aminobutyric acid, 2- aminopimelic acid, 3-aminobutyric acid, 3-aminopropionic acid, 4-aminobutyric acid, 6-aminocaproic acid, azetidine-2-carboxylic acid, beta-alanine, canaline, citrulline, gamma-aminobutyric acid (GABA), hydroxylysine, hydroxyproline, homocysteine, homoserine, isovaline, L-3,4-dihydroxyphenylalanine (L-DOPA), norleucine, norvaline, ornithine, pipecolic acid, sarcosine, selenocysteine, selenomethionine, and taurine, optionally wherein the non-proteogenic amino acid is selected from the group consisting of γ-aminobutyric acid (GABA), selenomethionine or a derivative thereof, ornithine, selenocysteine, pipecolic acid or a derivative thereof, and L-3,4- dihydroxyphenylalanine (L-DOPA), optionally wherein the non-proteogenic amino acid comprises γ-aminobutyric acid (GABA).

4. The agricultural composition of claim 1, wherein the desert plant extract comprises an extract from: a) a plant of a genera selected from the group consisting of: Abronia, Acacia, Agave, Baileya, Berberis, Bursera, Carnegiea, Chilopsis, Dasylirion, Echinocactus, Encelia, Eremophila, Euphorbia, Ferocactus, Flourensia, Fouquieria, Hesperocallis, Larrea, Oenothera, Opuntia, Parkinsonia, Salvia, Stenocereus, Xerophyllum, and Yucca;ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 b) a plant of a species selected from the group consisting of: Acacia rigidula, Agave sp., Aloe dichotomum, Barrel cactus (Echinocactus sp. and Ferocactus sp.), Beargrass (Xerophyllum tenax), Berberis trifoliolata, Brittle bush (Encelia farinosa), Candelilla (Euphorbia antisyphilitica), Cholla Cactus (Opuntia), Creosote bush (Larrea tridentata), Desert lily (Hesperocallis undulata), Desert marigold (Baileya spp.), Desert sage (Salvia dorrii), Desert spoon (Dasylirion wheeleri), Desert willow tree (Chilopsis linearis), Dune Primrose (Oenothera deltoides), Elephant tree (Bursera microphylla), Eremophila glabra, Euphorbia antisyphilitica, Ferocactus pilosus, Fishhook barrel cactus (Ferocactus wislizeni), Mahonia trifoliolata, Organ pipe cactus (Stenocereus thurberi), Ocotillo (Fouquieria splendens), Palm plants, Palo verde (Parkinsonia sp.), Prickly pear cactus (Opuntia sp.), Saguaro cactus (Carnegiea gigantea), Sand Verbena (Abronia villosa), Sotol (Dasylirion sp.), Tarbush (Flourensia cernua), and Yucca sp; and / or c) a plant selected from Desert lily (Hesperocallis undulata), Agave Lechuguilla, Yucca sp., and Tarbush (Flourensia cernua).

5. The agricultural composition of claim 1, wherein the desert plant extract comprises an extract from Yucca.

6. The agricultural composition of claim 1, wherein the composition comprises an algae extract, optionally derived from microalgae or macroalgae.

7. The agricultural composition of claim 1, wherein the algae extract is derived from kelp, optionally wherein the algae extract comprises Ascophyllum nodosum and / or Ecklonia maxima extract.

8. The agricultural composition of claim 1, wherein the composition comprises sugar, optionally in the form of molasses or cane water.

9. The agricultural composition of claim 1, wherein the composition comprises a chelating agent, optionally selected from citric acid or sodium glucoheptonate.

10. The agricultural composition of claim 1, wherein the composition comprises a compound of Formula (I) having the structure:ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 ,wherein: R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2.

11. The composition of claim 10, wherein: a) X is Na+and n is 1; b) X is K+and n is 1; or c) X is Ca2+and n is 2.

12. The composition of claim 10, wherein: a) R is the sidechain of a proteogenic amino acid, optionally wherein the sidechain is -CH3, -CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3, -CH2OH, - CH(OH)CH3, -(CH2)4NH2, -(CH2)3NH(C=N)NH2, -CH2COOH, - (CH2)2COOH, -CH2CONH2, -(CH2)2CONH2, -(CH2)2SCH3, -CH2SH, -CH2Ph, -CH2-(4-hydroxyphenyl), -CH2-(1H-imidazol-4-yl), or -CH2-(1H-indol-3-yl); b) R is the sidechain of a non-proteogenic amino acid, optionally wherein R is - CH2NH2, -(CH2)2NH2, -(CH2)3NH2, -(CH2)2SeCH3, -CH2SeH, -CH2-(CO)- NH2, -(CH2)2-(CO)-NH2, -CH2CH2O-NH2, -CH2CH2Ph, -(CH2)3NH-(CO)-ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 , c)alkylene-NH(C=N)NH2, alkylene-SH, alkylene-S-alkyl, alkylene-phenyl, or alkylene-heteroaryl.

13. The composition of claim 10, wherein R1is H.

14. The composition of claim 10, wherein R and R1taken together with the atoms to which they are attached form a 6-membered ring, wherein the 6-membered ring has the .

15. The10, wherein m is 0.

16. The composition of claim 10, wherein R is H and m is 2.

17. The composition of claim 10, wherein the compound has the structure of Formula (Ia): , or a18. The composition of claim 10, wherein the compound has the structure of Formula (Ib): (Ib).ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 19. The composition of claim 10, wherein the compound has the structure of Formula (I- 1): 1).

20. An agriculturala) an amino acid mixture comprising proteogenic and non-proteogenic amino acids; b) a desert plant extract; c) an algae extract; d) and sugar.

21. The agricultural composition of claim 20, wherein the desert plant extract comprises 0.01-10% w / w of the agricultural composition, optionally 0.5-5% w / w of the agricultural composition.

22. The agricultural composition of claim 20, wherein the amino acid mixture comprises 0.1-10% w / w of the agricultural composition, optionally 0.5-5% w / w of the agricultural composition 23. The agricultural composition of claim 20, wherein the amino acid mixture comprises GABA, optionally wherein the GABA comprises 0.05-5% w / w of the agricultural composition.

24. The agricultural composition of claim 20, wherein the algae extract comprises 0.1-10% w / w of the agricultural composition, optionally 0.5-5% w / w of the agricultural composition.

25. The agricultural composition of claim 20, wherein the sugar comprises 0.05-25% w / w of the agricultural composition, optionally 0.1-5% w / w of the agricultural composition.

26. The agricultural composition of claim 20, wherein the composition comprises nitrogen, phosphorous, or potassium, optionally wherein the composition comprises nitrogen and potassium, optionally wherein the composition comprises 1-10% w / w nitrogen and / or 5-20% w / w potassium.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 27. The agricultural composition of claim 20, wherein the composition comprises 0.1-100 ppm of a micronutrient, optionally zinc, magnesium, boron, iron, and / or manganese.

28. An agricultural composition comprising: a) 0.1-10% w / w desert plant extract; b) 0.05-5% w / w GABA; c) 0.1-5% w / w Kelp extract; d) 0.1-15% w / w sugar; and e) 0.5-10% w / w protein hydrolysates; f) 10-50% w / w potassium acetate; and g) 0.5-20% w / w urea.

29. A composition comprising: (a) a compound of Formula (I) having the structure: (I),wherein: R is H or a sidechain of an amino acid; R1is H or C1-5 alkyl; or R and R1taken together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring; X is Na+, K+, or Ca2+; m is 0, 1, or 2; and n is 1 or 2; and (b) one or more additives.

30. The composition of claim 29, wherein X is Na+and n is 1.ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 31. The composition of claim 29, wherein X is K+and n is 1.

32. The composition of claim 29, wherein X is Ca2+and n is 2.

33. The composition of claim 29, wherein R is the sidechain of a proteogenic amino acid.

34. The composition of claim 29, wherein R is the sidechain of a proteogenic amino acid, and wherein the sidechain is -CH3, -CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, - CH(CH3)CH2CH3, -CH2OH, -CH(OH)CH3, -(CH2)4NH2, -(CH2)3NH(C=N)NH2, - CH2COOH, -(CH2)2COOH, -CH2CONH2, -(CH2)2CONH2, -(CH2)2SCH3, -CH2SH, - CH2Ph, -CH2-(4-hydroxyphenyl), -CH2-(1H-imidazol-4-yl), or -CH2-(1H-indol-3-yl).

35. The composition of claim 29, wherein R is the sidechain of a non-proteogenic amino acid.

36. The composition of claim 29, wherein R is -CH2NH2, -(CH2)2NH2, -(CH2)3NH2, - (CH2)2SeCH3, -CH2SeH, -CH2-(CO)-NH2, -(CH2)2-(CO)-NH2, -CH2CH2O-NH2, - , 37.alkylene-NH2, alkylene-CO-NH2, alkylene-NH(C=N)NH2, alkylene-SH, alkylene-S- alkyl, alkylene-phenyl, or alkylene-heteroaryl.

38. The composition of claim 29, wherein R1is H.

39. The composition of claim 29, wherein R and R1taken together with the atoms to which they are attached form a 6-membered ring, wherein the 6-membered ring has the .

40. The 29, wherein m is 0.

41. The composition of claim 29, wherein R is H and m is 2.

42. The composition of claim 29, wherein the compound has the structure of Formula (Ia):ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 (Ia), or a43. The composition of claim 29, wherein the compound has the structure of Formula (Ib): .

44. Theof Formula (I- 1): . 45.(I-1) having the structure: (I-1), the methodand an amino acid (2) under acidic conditions and at a temperature greater that 40°C, according to the following reaction scheme: .ATTORNEY DOCKET NO.: COAG-001 / 01WO 351598-2005 46. A method of producing a composition according to any one of claims 1-44.

47. A method of growing a plant, said method comprising applying the composition of any one of claims 1-44 to a plant.

48. The method of claim 67, wherein the plant displays a phenotype selected from the group consisting of: improved germination, improved stress tolerance, improved resistance to at least one disease, increased growth, increased fresh weight, increased dry weight, increased secondary metabolite content; increased flowering, increased fruit size, increased number of marketable fruit and increased harvest index.

49. The method of claim 67, wherein the agricultural composition is applied: a) as a soil spray or soil drench; b) as a foliar spray; c) as a seed treatment or seed coating; and / or d) as a granular fertilizer.

Images