Oral appliance formed of polyurethane-based resin including ionically charged modifier

The oral appliance uses a polyurethane-based resin with ionically charged modifiers to sustainably release fluoride ions and antimicrobial agents, addressing dental caries and plaque issues through targeted delivery.

WO2025178766A1 Publication Date: 2025-08-28BECTON DICKINSON & CO
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Patent Information

Application Number
PCT/US2025/014850
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-02-21
Filing Date
2025-02-06
Publication Date
2025-08-28

AI Technical Summary

Technical Problem

Existing oral hygiene products do not effectively provide sustained release of fluoride ions and antimicrobial agents, leading to inadequate prevention of dental caries and plaque buildup.

Method used

An oral appliance formed of a polyurethane-based resin incorporating ionically charged modifiers, which are bonded with ionic active agents such as fluoride ions and antimicrobial agents, allowing for slow release and targeted delivery of these agents during use.

Benefits of technology

The appliance provides sustained release of fluoride ions to strengthen tooth enamel and inhibit dental caries, while also delivering antimicrobial agents to control plaque and gingivitis, offering improved oral hygiene with customizable and targeted treatment.

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Abstract

An oral appliance configured for temporary use in a patient's mouth. The oral appliance has an oral appliance body formed from an ionic polyurethane-based resin, which is a reaction product of ingredients including a diisocyanate, a diol chain extender, a polyglycol, and an ionically charged modifier. An ionic active agent is ionically bound to the ionically charged modifier. This may be done by solution imbibing technique or bulk mixing (e.g., thermal compounding or solvent mixing) technique. The ionic active agent may include fluoride ions. The ionic active agent may include an antimicrobial agent. The ionic active agent may include one or more essential oils.
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