Liquid oral composition

Abstract

A liquid oral composition containing component (a): copper gluconate, component (b): zinc chloride, and component (c): sodium L-aspartate.

Description

liquid oral composition

[0001] The present invention relates to a liquid oral composition.

[0002] Techniques for incorporating metal compounds into oral preparations are described in Patent Documents 1 to 5. Patent Document 1 (JP 2003-137755 A) describes an oral composition containing a compound that releases one or more metal ions selected from copper, zinc, aluminum, iron, and tin, and further containing one or more compounds selected from the group consisting of an L-menthol derivative and N-ethyl-p-menthane-3-carboxamide (Claim 1). A specific example of the oral composition is a mouthwash containing specific amounts of specific components, including copper gluconate and zinc chloride (Example 26). According to this document, the oral composition has an improved metallic taste, a pleasant feel when used, and high commercial value (Paragraph 0023).

[0003] Patent Document 2 (JP 2000-159647 A) describes a technique for improving the feel of a dentifrice composition (paragraph 0003), which is a dentifrice composition containing one or more members selected from the group consisting of condensed phosphates, hydrogen carbonates, and hydrogen sulfates, and a water-soluble transition metal compound, and further containing one or more members selected from amino acids and their salts, and proteins (claim 1).

[0004] Patent Document 3 (JP 2019-108276 A) describes an oral composition containing pyrrolidonecarboxylic acid or an inorganic base salt thereof and zinc oxide (claim 1). According to this document, it is possible to provide an oral composition that can improve the whitening effect on tooth root surfaces and the duration of the effect, as well as reduce the metallic taste that can be experienced when using the composition (paragraph 0009).

[0005] Patent Document 4 (JP 2022-99623 A) and Patent Document 5 (JP 2022-99624 A) describe that water-soluble copper salts such as copper gluconate have a deodorizing effect and are widely used in oral compositions such as dentifrices and mouthwashes for the purpose of preventing bad breath (paragraph 0002 of Patent Document 4, paragraph 0002 of Patent Document 5). These documents aim to provide oral compositions containing water-soluble copper salts and suppressing metallic taste (paragraph 0006 of Patent Document 4, paragraph 0006 of Patent Document 5), and describe oral compositions containing water-soluble copper salts and specific plant extracts (claim 1 of Patent Document 4, claim 1 of Patent Document 5).

[0006] JP 2003-137755 A JP 2000-159647 A JP 2019-108276 A JP 2022-99623 A JP 2022-99624 A

[0007] Through investigations by the present inventors, it was newly discovered that when copper gluconate and zinc chloride are blended together in an oral composition, the metallic taste increases and the feeling of use deteriorates, but when, for example, a metal chelating agent is further blended into the composition in order to prevent this deterioration in the feeling of use, the bad breath suppression effect is reduced.

[0008] Therefore, the present invention provides a technology that suppresses the metallic taste of a liquid oral composition while improving its bad breath suppression effect.

[0009] According to the present invention, the following liquid oral composition and metallic taste suppression method are provided. [1] A liquid oral composition comprising the following components (a) to (c): (a) copper gluconate (b) zinc chloride (c) sodium L-aspartate [2] The liquid oral composition according to [1], wherein the content of component (c) is 0.1% by mass or more and 2% by mass or less with respect to the total content of the liquid oral composition. [3] The liquid oral composition according to [1] or [2], wherein the mass ratio (c) / ((a) + (b)) of the content of component (c) to the total content of components (a) and (b) in the liquid oral composition is 0.1 or more and 20 or less. [4] The liquid oral composition according to any one of [1] to [3], which is a metallic taste suppressant. [5] The liquid oral composition according to any one of [1] to [4], which is a mouthwash. [6] A method for suppressing a metallic taste, comprising blending the following component (c) with a liquid oral composition containing the following components (a) and (b): (a) copper gluconate, (b) zinc chloride, and (c) sodium L-aspartate.

[0010] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention.

[0011] According to the present invention, the metallic taste of a liquid oral composition can be suppressed while its bad breath suppression effect is excellent.

[0012] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component alone or in combination of two or more. In this specification, the term "to" indicating a numerical range means "at least" or "at most," and both end values ​​are included.

[0013] (Liquid Oral Composition) In this embodiment, the liquid oral composition contains the following components (a) to (c): (a) copper gluconate, (b) zinc chloride, and (c) sodium L-aspartate.

[0014] The liquid oral composition of this embodiment contains a combination of the above components (a) to (c), thereby suppressing the metallic taste of the liquid oral composition and achieving an excellent effect of suppressing bad breath. Furthermore, in this embodiment, the liquid oral composition is also suitable as a metallic taste suppressant. Each component will be described below.

[0015] (Component (a)) Component (a) is copper gluconate. As component (a), for example, a commercially available product can be used.

[0016] The content of component (a) in the liquid oral composition is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.03% by mass or more, and even more preferably 0.08% by mass or more, based on the total mass of the liquid oral composition. This can improve the bad breath suppression effect. The content of component (a) in the liquid oral composition is preferably 10% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and even more preferably 0.2% by mass or less, based on the total mass of the liquid oral composition. This can improve the metallic taste suppression effect. The content of component (a) in the liquid oral composition can be equal to or less than the solubility in the solvent in the liquid oral composition.

[0017] (Component (b)) Component (b) is zinc chloride. As component (b), for example, a commercially available product can be used.

[0018] The content of component (b) in the liquid oral composition is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.03% by mass or more, and even more preferably 0.08% by mass or more, based on the total mass of the liquid oral composition. This can improve the bad breath suppression effect. The content of component (b) in the liquid oral composition is preferably 10% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and even more preferably 0.2% by mass or less, based on the total mass of the liquid oral composition. This can improve the metallic taste suppression effect. The content of component (b) in the liquid oral composition can be equal to or less than the solubility in the solvent in the liquid oral composition.

[0019] The mass ratio (b) / (a) of the content of component (b) to the content of component (a) in the liquid oral composition is preferably 0.1 or more, more preferably 0.3 or more, even more preferably 0.5 or more, and is preferably 10 or less, more preferably 5 or less, even more preferably 3 or less. This makes it possible to further improve the metallic taste suppression effect and bad breath suppression effect.

[0020] (Component (c)) Component (c) is sodium L-aspartate. As component (c), for example, a commercially available product can be used.

[0021] The content of component (c) in the liquid oral composition is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.5% by mass or more, and even more preferably 0.8% by mass or more, based on the total amount of the liquid oral composition. This can improve the metallic taste suppression effect. The content of component (c) in the liquid oral composition is preferably 2% by mass or less, more preferably 1.5% by mass or less, and even more preferably 1.2% by mass or less, based on the total amount of the liquid oral composition. This can improve the metallic taste suppression effect. The content of component (c) in the liquid oral composition can be equal to or less than the solubility in the solvent in the liquid oral composition.

[0022] The mass ratio (c) / ((a)+(b)) of the content of component (c) to the total content of components (a) and (b) in the liquid oral composition is preferably 0.1 or more, more preferably 1 or more, even more preferably 3 or more, and is preferably 20 or less, more preferably 10 or less, even more preferably 7 or less. This can improve the metallic taste suppression effect.

[0023] The liquid oral composition may contain components other than components (a) to (c). For example, the liquid oral composition may contain at least one compound selected from the group consisting of a copper compound other than component (a) and a zinc compound other than component (b). The liquid oral composition specifically contains water.

[0024] (Water) The content of water in the liquid oral composition can be, for example, the remainder after removing components other than water from the liquid oral composition. The content of water in the liquid oral composition is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 70% by mass or more, and preferably 99.9% by mass or less, more preferably 99.8% by mass or less, even more preferably 99% by mass or less, based on the entire liquid oral composition. The liquid oral composition is, for example, an aqueous composition, and preferably an aqueous composition containing 50% by mass or more of water.

[0025] (Ethanol) The liquid oral composition may further contain ethanol. The ethanol content in the liquid oral composition is preferably 0.1% by mass or more, more preferably 1% by mass or more, and even more preferably 2% by mass or more. This provides a moderately refreshing and pleasant feeling when used. The ethanol content in the liquid oral composition is preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 10% by mass or less, even more preferably 7.5% by mass or less, and even more preferably 5% by mass or less. This prevents strong irritation to the oral cavity. In this regard, it is also preferable that the liquid oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or that the liquid oral composition contains ethanol but the ethanol content is 5% by mass or less.

[0026] (Other Components) The liquid oral composition may contain components other than those described above, as long as they do not impair the effects of the present invention. Such components include, for example, medicinal components, binders, humectants, flavoring agents, preservatives, colorants, pH adjusters, solvents other than those mentioned above, solubilizers, bases, detergents, adsorbents, etc., and can be selected appropriately depending on the dosage form. Specific examples of added components are shown below, but the components that can be added in the present invention are not limited to these.

[0027] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0028] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0029] Examples of anti-inflammatory agents include one or more selected from the group consisting of β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0030] An example of a blood circulation promoter is sodium chloride.

[0031] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0032] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0033] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0034] Examples of vitamin preparations include one or more selected from the group consisting of ascorbic acid, L-ascorbic acid, sodium ascorbate, L-sodium ascorbate, pyridoxine hydrochloride, DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0035] An example of a plaque decomposing enzyme is dextranase.

[0036] Examples of the binder include one or more selected from the group consisting of organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers, thickening anhydrous silicic acid, and bentonite.

[0037] From the viewpoint of facilitating rinsing the oral cavity, the liquid oral composition preferably does not contain xanthan gum, and more preferably does not contain a binder. Here, "the liquid oral composition does not contain xanthan gum or a binder" specifically means that xanthan gum or a binder is not intentionally blended into the liquid oral composition, and more specifically means that the content of xanthan gum or a binder is 0.001% by mass or less of the entire liquid oral composition.

[0038] The humectant may be any one that is commercially available as a pharmaceutical, food, or cosmetic ingredient, and examples thereof include polyhydric alcohols, and more specifically, one or more selected from the group consisting of sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0039] From the viewpoint of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of glycerin and propylene glycol, and more preferably glycerin.

[0040] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose, or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0041] From the viewpoint of having a strong sweetness and being able to adjust the taste even with a small amount, the flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium.

[0042] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate; and alkyldiaminoethylglycine hydrochloride. The content of the preservative in the liquid oral composition can be, for example, 0.01 to 1% by mass of the entire liquid oral composition.

[0043] Examples of coloring agents include one or more selected from the group consisting of natural dyes such as safflower red dye, gardenia yellow dye, gardenia blue dye, perilla dye, red koji dye, red cabbage dye, carrot dye, hibiscus dye, cacao dye, spirulina blue dye, and coumarind dye; legally mandated dyes such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin, and titanium dioxide.

[0044] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffers. The content of the preservative in the liquid oral composition can be, for example, 0.001 to 1% by mass in the example based on the entire liquid oral composition.

[0045] Examples of the solvent include water and ethanol as mentioned above, as well as lower alcohols such as propanol.

[0046] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0047] The base may be, for example, sodium bicarbonate.

[0048] Detergents include, for example, sodium polyphosphate.

[0049] The adsorbent may be, for example, β-cyclodextrin.

[0050] Furthermore, in addition to the above components, components that are generally suitable for use in oral compositions such as liquid oral compositions can also be appropriately blended within the scope that does not impair the content of the present invention.

[0051] (pH) The pH of the liquid oral composition is preferably 4.0 or higher, more preferably 4.5 or higher, and even more preferably 4.7 or higher. This can prevent tooth decalcification. The pH of the liquid oral composition is preferably 7.0 or lower, more preferably 6.5 or lower, even more preferably 6.0 or lower, and even more preferably 5.5 or lower. The pH of the liquid oral composition can be measured at 25°C using a commercially available pH meter.

[0052] (Liquid Preparation) The liquid oral composition is specifically a liquid preparation. The liquid preparation is specifically an orally administered preparation. A specific embodiment of the liquid oral composition is one selected from the group consisting of mouthwash, liquid toothpaste, and mouth freshener. The liquid oral composition is preferably a mouthwash. This allows for the effect of suppressing bad breath to be easily achieved in daily life.

[0053] (Manufacturing method) In this embodiment, the liquid oral composition includes, for example, a step of blending components (a) to (c) and, as appropriate, other components.

[0054] (Method for suppressing metallic taste) In this embodiment, the method for suppressing metallic taste comprises blending the component (c) with the liquid oral composition containing the components (a) and (b). This method effectively suppresses the metallic taste while preventing a decrease in the bad breath suppressing effect of the liquid oral composition.

[0055] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted.

[0056] The present embodiment will be specifically described below with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0057] (Example 1, Comparative Example 1) The components listed in Table 1 were mixed to prepare mouthwashes for each example, and the mouthwashes were evaluated using the methods described below. Details of the components listed in each table are as follows: (a) Copper gluconate: Healthy Cu, manufactured by Fuso Chemical Co., Ltd. Paraoxybenzoic acid ester: Mekxance M, manufactured by Ueno Pharmaceutical Co., Ltd.

[0058] (Method of preparing mouthwash) Mouthwash of each example was obtained by mixing the components shown in Table 1. The pH of the obtained mouthwash at 25°C was measured using a pH meter (LAQUA F-72, manufactured by Horiba, Ltd.).

[0059] (Evaluation method) The metallic taste of each example of mouthwash was evaluated using the following method. One subject evaluated the usability. 10 mL of each example of mouthwash was placed in the mouth, rinsed thoroughly for 20 seconds, and then spat out. Each was evaluated using the following rating scale. Rating scale: 5: No metallic taste 4: Almost no metallic taste 3: Slight metallic taste, but within acceptable limits 2: Metallic taste 1: Strong metallic taste

[0060] Evaluation was made based on the following evaluation criteria using the scores given by one subject once. The evaluation results are shown in Table 1. A: 4.0 points or more B: 3.0 points or more but less than 4.0 points C: Less than 3.0 points

[0061]

[0062] As can be seen from Table 1, the metallic taste of the mouthwash in Example 1, which contains a combination of components (a) to (c), was effectively suppressed. Furthermore, by using the mouthwash of Example 1, a bad breath suppression effect can be obtained.

[0063] This application claims priority based on Japanese Patent Application No. 2024-029638, filed February 29, 2024, the disclosure of which is incorporated herein in its entirety by reference.

Claims

1. A liquid oral composition comprising the following ingredients (a) to (c): (a) copper gluconate, (b) zinc chloride, and (c) sodium L-aspartate.

2. A liquid oral composition as described in claim 1, wherein the content of component (c) is 0.1 mass% or more and 2 mass% or less of the total liquid oral composition.

3. A liquid oral composition as described in claim 1 or 2, wherein the mass ratio (c) / ((a) + (b)) of the content of component (c) to the total content of components (a) and (b) in the liquid oral composition is 0.1 or more and 20 or less.

4. A liquid oral composition described in any one of claims 1 to 3, which is a metallic taste suppressant.

5. A liquid oral composition described in any one of claims 1 to 4, which is a mouthwash.

6. A method for suppressing metallic taste, comprising blending the following component (c) with a liquid oral composition containing the following components (a) and (b): (a) copper gluconate, (b) zinc chloride, and (c) sodium L-aspartate.

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