Polymer-containing composition having increased UV blocking boosting effect and cosmetic composition comprising same

Abstract

The present invention relates to a UV blocking efficacy booster composition comprising a polymer, and a cosmetic composition comprising same. More specifically, by using a polymer as a cosmetic composition additive, a sticky feeling when used may be reduced, skin permeation may be blocked, a high sun protection factor (SPF) may be realized even with a small amount of a UV blocking agent, and the SPF in vivo may be enhanced.

Description

Polymer-containing composition having enhanced UV protection boosting effect and cosmetic composition comprising the same

[0001] The present invention relates to a composition having an enhanced UV protection boosting effect, including a polymer. More specifically, the present invention relates to a composition having an enhanced UV protection boosting effect, including a polymer as an additive to a cosmetic composition, which improves a sticky feeling when used, prevents skin penetration, provides a high SPF (sun protection factor) despite a low content of sunscreen, and can enhance the SPF in vivo, and a cosmetic composition comprising the same.

[0002] Sunscreens can be broadly categorized into inorganic and organic sunscreens. Each sunscreen ingredient has a mixing limit set by the Ministry of Food and Drug Safety. Considering these mixing limits, inorganic sunscreens can cause a white cast on the skin and have a thick consistency that makes them difficult to apply. Furthermore, they are known to cause cancer or increase the risk of dementia if absorbed through the skin. Organic sunscreens are also absorbed through the skin, and if absorbed in amounts exceeding safety standards, they can increase the risk of adverse effects such as cancer and birth defects.

[0003] When UV protection ingredients are absorbed into the dermis layer of the skin in this way, side effects that cause skin cancer occur. To solve this problem, if UV protection ingredients are contained in a material that can strengthen SPF, the UV protection ingredient can be used less and absorption into the skin can be suppressed. In addition, existing organic sunscreens have a high content of organic sunscreen ingredients of 30% by weight of the total weight of the sunscreen, and due to the sticky nature of organic sunscreens, they have the disadvantage of not being comfortable to use.

[0004] Additionally, there was a recent issue with SPF manipulation in sunscreen products on the market. The common characteristic of these products was that they used organic sunscreen ingredients, and the commonly used organic sunscreen ingredients included UV-A blocking ingredients such as Diethylamino Hydroxybenzoyl Hexyl Benzoate (Diethylamino Hydroxybenzoyl Hexyl Benzoate) Uvinul A+, UV-B ingredients such as Ethylhexyl Triazone (Ethylhexyl Triazone) Uvinul T 150, and UV-A blocking ingredients such as Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) Tinosorb S, and it was said that these products contained two or three sunscreen ingredients.

[0005] It is known that it is not easy to create the effect of SPF 50+ or ​​PA ++++ with these two or three ingredients when manufacturing sunscreen, and adding each ingredient at the maximum amount has become a problem because it can cause irritation regardless of the EWG grade. In addition, since the SPF value is affected by UV-B blocking, a lot of UV-B blocking agent must be added to increase the value, so the SPF value is usually increased by adding 5 to 7% by weight of organic sunscreen ingredients and a lot of inorganic sunscreen related to coverage. In addition, SPF can be increased with UV-A blocking agent, but since the amount added has to be large, most products use UV-B, and most products use a mixture of two or three organic sunscreen ingredients and inorganic sunscreen.

[0006] Accordingly, there was a need to develop a sunscreen having an effect of SPF 50+ and PA ++++ while minimizing the content of organic sunscreens to less than 5% by weight and without using inorganic sunscreens, and an additive that can be added to existing sunscreens.

[0007] (Patent Document 1) Korean Publication No. 10-2011-0137157 A (December 22, 2011)

[0008] The inventors of the present invention conducted research to address the shortcomings of the prior art as described above, and as a result, discovered that the present invention has a booster effect that maximizes UV protection efficacy despite having a lower content of UV protection agent than existing products, and improves the sticky feeling of use, and also suppresses the phenomenon of organic sunscreen ingredients being absorbed into the skin and naturally decomposes when disposed of, thereby minimizing environmental pollution.

[0009] Accordingly, the present invention aims to provide a UV blocking efficacy booster composition having the above-described function.

[0010] According to one embodiment of the present invention, a UV-blocking effect booster composition comprising a polymer is provided, wherein the D50 (volume) of the polymer included in the composition is 0.1 to 10 μm.

[0011] In addition, according to one embodiment of the present invention, the polymer is characterized in that it is a biodegradable polymer.

[0012] In addition, according to one embodiment of the present invention, the polymer is characterized by having at least one functional group among an NH- group and a carbonyl group.

[0013] In addition, according to one embodiment of the present invention, the polymer is characterized in that it is at least one selected from the group consisting of PHA (Poly hydroxyalkanoate), PBAT (Polybutylene adipate terephthalate), PBS (polybutylene succinate), PCL (polycaprolactone), PMMA (Poly methyl methacrylate), PLLA (Poly L-lactic acid), and PEI (Poly ethylene imine).

[0014] According to one embodiment of the present invention, a polymer; and an oil; are included in the composition, and D of the polymer included in the composition 50 A cosmetic composition having a volume of 0.1 to 10 μm is provided.

[0015] In addition, according to one embodiment of the present invention, a cosmetic composition characterized in that the polymer encapsulates a sunscreen ingredient.

[0016] In addition, according to one embodiment of the present invention, the polymer is characterized in that the composition is included in an amount of more than 0 and less than 10 wt% relative to the total weight of the cosmetic composition.

[0017] In addition, according to one embodiment of the present invention, the cosmetic composition further comprises an organic sunscreen other than the polymer, and the organic sunscreen is characterized in that it is at least one selected from the group consisting of ethylhexyl methoxycinnamate (OMC), bis-ethylhexyloxyphenol methoxyphenyl triazine (TS), polysilicon-15, isoamyl p-methoxycinnamate, diethylaminohydroxybenzoylhexyl benzoate, ethylhexyl triazone, butyl methoxydibenzoylmethane, ethylhexyl salicylate, ethylhexyl cinnamate, homosalate, ethylhexyl triazone, and octocrylene.

[0018] In addition, according to one embodiment of the present invention, the cosmetic composition is characterized in that it is for blocking ultraviolet rays.

[0019]

[0020] In addition, according to one embodiment of the present invention, the composition is characterized in that it has a formulation selected from the group consisting of a solution, an ointment, an external ointment, a cream, an essence, a foam, a toner, a nourishing toner, an emollient, an emollient toner, a pack, a milky lotion, a makeup base, a soap, a cleanser, a bath agent, a sunscreen, a sun oil, a suspension, an emulsion, a paste, a gel, a lotion, a powder, a soap, a cleansing agent containing a surfactant, an oil, a foundation, a powder foundation, an emulsion foundation, a wax foundation, a patch, and a spray.

[0021] The UV-blocking efficacy booster composition and the cosmetic composition comprising the same according to the present invention have a booster effect that can maximize UV-blocking efficacy despite containing less UV-blocking ingredients than existing products, and improve the feeling of use by containing less UV-blocking ingredients that have a sticky feel. In addition, not only does it have a booster effect that can maximize UV-blocking efficacy by suppressing the phenomenon of organic sunscreen ingredients being absorbed into the skin, but it also has the advantage of being naturally decomposed when disposed of, thereby minimizing environmental pollution.

[0022] Figure 1 is a graph of UV Spectrum data, which is the result of an in vitro analysis showing that when a dispersion (including PHA) according to one embodiment of the present invention is added, the UV-A and B regions are expanded overall, and thus the SPF / PA is increased.

[0023] Hereinafter, the present invention will be described in more detail.

[0024] Terms or words used in this specification and claims should not be interpreted as limited to their usual or dictionary meanings, but should be interpreted as meanings and concepts that conform to the technical idea of ​​the present invention, based on the principle that the inventor can appropriately define the concept of the term to explain his or her own invention in the best way.

[0025] The terminology used in the present invention is only used to describe specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In the present invention, it should be understood that the terms "comprise" or "have" are intended to specify the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not exclude in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0026]

[0027] First, the present invention is a UV blocking efficacy booster composition comprising a polymer, wherein D of the polymer included in the composition 50 A booster composition having a UV blocking effect having a volume of 0.1 to 10 μm is provided.

[0028] The inventors of the present invention have discovered that by using a polymer to suppress the absorption of sunscreen ingredients into the skin, not only can it have a booster effect that maximizes the effectiveness of sunscreen, but it can also minimize environmental pollution by naturally decomposing when disposed of.

[0029] The UV blocking efficacy booster composition according to the present invention comprises a polymer, which may be, but is not limited to, a biodegradable polymer.

[0030] The polymer included in the UV blocking efficacy booster composition according to the present invention is PHA (Poly hydroxyalkanoate), and further, according to one embodiment of the present invention, the polymer is characterized in that it is at least one selected from the group consisting of PHA (Poly hydroxyalkanoate), PBAT (Polybutylene adipate terephthalate), PBS (polybutylene succinate), PCL (polycaprolactone), PMMA (Poly methyl methacrylate), PLLA (Poly L-lactic acid), and PEI (Poly ethylene imine).

[0031] When these polymers are used together with sunscreen ingredients, they not only have a booster effect that maximizes the effectiveness of sunscreen by suppressing the absorption of the sunscreen ingredients into the skin, but also minimize environmental pollution as they are naturally decomposed when disposed of.

[0032] Additionally, the polymer included in the UV-blocking efficacy booster composition according to the present invention may have at least one functional group selected from the group consisting of an NH- group and a carbonyl group. When polymers having these functional groups are used together with a UV-blocking agent, the phenomenon of the UV-blocking agent being absorbed into the skin can be suppressed.

[0033] In addition, the polymer included in the UV blocking efficacy booster composition according to the present invention is D of the polymer included in the composition. 50 (volume) can be 0.1 to 10 ㎛. Here, D 50 (volume) means the particle size corresponding to the cumulative particle size distribution percentage in the polymer powder reaching 50% by volume. D of the polymer 50When (volume) has the above range, when used together with a sunscreen ingredient, it has a booster effect that can maximize the sunscreen effect and suppress the phenomenon of the sunscreen ingredient being absorbed into the skin.

[0034] Specifically, D of the polymer included in the above composition 50 (volume) may be 0.1 ㎛ or more, 0.3 ㎛ or more, 0.5 ㎛ or more, 1.0 ㎛ or more, 2.0 ㎛ or more, and may be 10 ㎛ or less, 8 ㎛ or less, 6 ㎛ or less, 5 ㎛ or less, 4 ㎛ or less, 3 ㎛ or less, or 1.5 ㎛ or less.

[0035] Next, the present invention provides a cosmetic composition comprising the above UV blocking efficacy booster composition.

[0036] The cosmetic composition of the present invention comprises a polymer; and an oil; and D of the polymer 50 (volume) is characterized by being 0.1 to 10 ㎛.

[0037] The polymer included in the cosmetic composition of the present invention may encapsulate a sunscreen ingredient, but is not limited thereto.

[0038] The polymer included in the cosmetic composition of the present invention may be included in an amount of 0 to 10 wt% based on the total weight of the cosmetic composition, preferably 0.001 wt% or more, 0.01 wt% or more, 0.1 wt% or more, 1.0 wt% or more, 2.0 wt% or more, and 8 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, or 3 wt% or less.

[0039] If the content of the above polymer is higher than the above standard, there is a problem of the phenomenon of it being pushed into the skin.

[0040]

[0041] The cosmetic composition of the present invention may further include an organic sunscreen other than the polymer. The organic sunscreen included in the cosmetic composition of the present invention may be included in an amount of 3 to 10 wt% based on the total weight of the cosmetic composition. The cosmetic composition of the present invention, by including the polymer as described above, has a booster effect that maximizes UV protection efficacy despite a small content of the organic sunscreen.

[0042] If the content of the above organic solvent is lower than 3 wt%, there is a problem of minimal UV blocking effect, and if it is higher than 10 wt%, there is a problem of poor usability (stickiness).

[0043] Specifically, the organic solvent may be included in an amount of 3.0 wt% or more, 3.5 wt% or more, 4.0 wt% or more, or 4.5 wt% or more, and may be included in an amount of 10.0 wt% or less, 8.0 wt% or less, 6.0 wt% or less, or 4.5 wt% or less, relative to the total weight of the cosmetic composition.

[0044] Specifically, the organic solvent may be at least one selected from the group consisting of ethylhexyl methoxycinnamate (OMC), bis-ethylhexyloxyphenol methoxyphenyl triazine (TS), polysilicon-15, isoamyl p-methoxycinnamate, diethylaminohydroxybenzoylhexyl benzoate, ethylhexyl triazone, butyl methoxydibenzoylmethane, ethylhexyl salicylate, ethylhexyl cinnamate, homosalate, ethylhexyl triazone, and octocrylene.

[0045] The cosmetic composition of the present invention includes a UV blocking effect booster composition, and when bis-ethylhexyloxyphenol methoxyphenyl triazine (TS) is used as an organic sunscreen, it can have a UV blocking synergy effect that is 5 times or more or 10 times or more than when it is not used.

[0046]

[0047] In addition, the cosmetic composition of the present invention includes a UV blocking effect booster composition, and when ethylhexyl methoxycinnamate (OMC) is used as an organic sunscreen, it can have a UV blocking synergy effect of 1.5 times or more, or 2 times or more, or 5 times or more, or 10 times or more compared to when it is not used.

[0048]

[0049] Specific examples of the above polymers are identical to the contents of the polymers included in the UV blocking efficacy booster composition discussed above.

[0050] Additionally, the polymer may be included as an additive in existing sunscreens.

[0051] The above existing sunscreen may be any sunscreen available on the market.

[0052] The cosmetic composition of the present invention can be used as an additive in any commercially available sunscreen. When used as an additive, the peak width of the UV spectrum and the SPF / PA value increase, as demonstrated in Experimental Example 4 below. Furthermore, even when the composition of the present invention is used as an additive at less than 1%, the boosting effect of the present invention occurs.

[0053]

[0054] The cosmetic composition of the present invention may include an inorganic sunscreen, and the inorganic sunscreen may be included in an amount of 1 to 10 wt% based on the total weight of the cosmetic composition.

[0055] If the content of the above-mentioned inorganic sunscreen is lower than 1 wt%, there is a problem that the physical UV blocking effect is minimal, and if it is higher than 10 wt%, there is a problem that the skin becomes white.

[0056] Specifically, the inorganic car may be included in an amount of 1.0 wt% or more, 2.0 wt% or more, 3.0 wt% or more, or 4.0 wt% or more, and may be included in an amount of 10.0 wt% or less, 8.0 wt% or less, 6.0 wt% or less, or 4.0 wt% or less, based on the total weight of the cosmetic composition.

[0057] Specifically, the above-mentioned inorganic self-cleaning agent may be at least one selected from the group consisting of zinc oxide, titanium dioxide, and cerium oxide.

[0058]

[0059] The oil included in the cosmetic composition of the present invention can be used without any special limitation as long as it is used in a cosmetic composition, and for example, MCT oil can be used.

[0060]

[0061] The cosmetic composition of the present invention may have a formulation selected from the group consisting of a solution, ointment, external ointment, cream, essence, foam, toner, nourishing toner, softening toner, softening toner, pack, emulsion, makeup base, soap, cleansing agent, bath agent, sunscreen, sun oil, suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, foundation, powder foundation, emulsion foundation, wax foundation, patch, and spray.

[0062]

[0063] The method for manufacturing the cosmetic composition of the present invention can be used without any particular limitation as long as it is a device capable of applying shear stress, and specifically, at least one device selected from the group consisting of a homogenizer, a high pressure homogenizer, packed silica, a rotor-stator homogenizer, a piston homogenizer, and a tube homogenizer can be used.

[0064] Specifically, the polymer of the present invention can be introduced into the above devices together with an emulsifier, and then mixed.

[0065] As the above emulsifier, polyoxyethylene sorbitan (Tween), polyoxyethylene-polyoxypropylene copolymer (poloxamer), sorbitan ester (Span), polyoxyethylene ether (Brij), and glycerin stearate citrate can be used, and an emulsifier such as Tween can be preferably used.

[0066] Additionally, the above mixing can be performed at a speed of 5000 to 10000 RPM for 3 to 10 minutes.

[0067] Afterwards, the process can be performed 1 to 5 times at a pressure of 1000 to 2000 bar using a high-pressure homogenizer (HPH).

[0068] After this, distilled water can be added again, and mixing can be done at a speed of 2000 to 5000 RPM for 5 to 15 minutes, after which the high-pressure homogenizer can be used again in the same manner as above.

[0069] After this, a solvent such as chloroform can be removed using a vacuum concentrator to prepare a final dispersion, which is a UV-blocking efficacy booster composition.

[0070] If necessary, an organic UV blocker such as TS or OMC may be added in advance during the step of manufacturing the booster composition.

[0071]

[0072] Thereafter, a cosmetic composition can be prepared by mixing various ingredients used in cosmetic compositions, such as MCT oil, phytosphingosine, lactic acid, 1-2-hexanediol, etc., and various organic or inorganic sunscreen ingredients discussed above, into the dispersion.

[0073] The present invention will be described in more detail below with reference to preferred embodiments. However, the scope of protection of the present invention is not limited by these embodiments.

[0074]

[0075] [Example]

[0076] 1. Chemicals used

[0077] 1) Preparation of dispersion

[0078] Chloroform, Glycerin Stearate Citrate (GSC), UV-filtering substances such as bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S), ethylhexyl methoxycinnamate (OMC); polyhydroxyalkanoate (PHA), 1-2-hexanediol (Activonol-6)

[0079] 2) Manufacturing of cosmetic composition

[0080] Caprylic / Capric Triglyceride (MCT Oil), Phytosphingosine, Lactic Acid, Titanium Dioxide (e.g., TiO2 Dispersion (Water Soluble, 30%), Agavati Commercial Product), 1-2-Hexanediol (Activonol-6 /

[0081]

[0082] Devices used

[0083] 1) Preparation of dispersion

[0084] Homomixer, high-pressure homogenizer (PandaPLUS 2000 from GEA Niro Soavi), rotary evaporator, oven, particle size analyzer (MasterSizer3000 from Malvern)

[0085] 2) Manufacturing of cosmetic composition

[0086] Homomixer, high pressure homogenizer (GEA Niro Soavi PandaPLUS 2000)

[0087] 3) SPF (sun protection factor) analysis

[0088] In vitro SPF measurement (SPF-290AS_Solar Light, Korea Institute of Ceramic Engineering and Technology)

[0089] In vivo SPF measurement (external analysis agency_Korea Institute of Dermatological Sciences, Gyeonggi-do / Skinmed, Daejeon)

[0090]

[0091] 1. Preparation of dispersion

[0092] Dispersion Manufacturing Example 1. Preparation of PHA (Polyhydroxyalkanoate) Dispersion Solution

[0093] In a beaker, 2.8 g of glycerin stearate citrate (GSC, dermofeel® GSC SG from EVONIK) powder and 14 g of polyhydroxyalkanoate (PHA, raw material from CJ-bio) powder were added. Then, chloroform was added so that the total weight became 400 g, and the homomixer was operated at 7,000 RPM for 5 minutes.

[0094] The solution thus prepared was homogenized three times at a pressure of 1,300 bar using a high-pressure homogenizer (HPH) to prepare the final solution.

[0095] Afterwards, 700 g of distilled water was added to the beaker, and the homomixer was operated at 3,000 RPM. 300 g of the previously prepared solution was slowly added, and the homomixer was operated at 5,000 RPM for 10 minutes to disperse the solution. Then, the HPH was used to perform the process 5 times at a pressure of 1,300 bar.

[0096] Afterwards, chloroform was completely removed at a temperature of 60°C using a rotary evaporator, and some distilled water was additionally removed using a vacuum evaporator to prepare the final dispersion.

[0097] The dry solid content of the manufactured dispersion (after drying in an 80℃ drying oven for more than 12 hours, the weight is measured to calculate the content of the residue) was confirmed to be 21 wt%, and the particle size distribution was analyzed using Malvern's MasterSizer3000 equipment and confirmed to be D50 (volume) 0.6㎛.

[0098]

[0099] Dispersion Manufacturing Example 2. Preparation of PHA Dispersion Solution Containing Organic UV Blocking Agent

[0100] 2.92 g of glycerin stearate citrate (GSC, dermofeel® GSC SG from EVONIK) powder and 14.60 g of polyhydroxyalkanoate (PHA) powder were added to a beaker.

[0101] Afterwards, chloroform was added so that the total weight was 400 g, and 5.26 g of bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S) powder and 12.26 g of ethylhexyl methoxycinnamate (OMC) solution were additionally added, and the homomixer was operated at 7,000 RPM for 5 minutes.

[0102] The solution thus prepared was processed three times at a pressure of 1,300 bar using HPH to prepare the final solution.

[0103] Afterwards, 700 g of distilled water was added to the beaker, and the homomixer was operated at 3,000 RPM. 300 g of the previously prepared solution was slowly added, and the mixture was dispersed by operating at 5,000 RPM for 10 minutes. Then, the HPH was used to perform the process 5 times at a pressure of 1,300 bar.

[0104] Afterwards, chloroform was completely removed at a temperature of 60°C using a rotary evaporator, and additionally, some distilled water was removed to prepare the final dispersion.

[0105] The dry solid content of the manufactured dispersion was confirmed to be 51 wt% as a result of analysis, and the particle size distribution was confirmed to be D50 (volume) 0.7 ㎛ as a result of analysis.

[0106]

[0107] Dispersion Manufacturing Example 3. Manufacturing of PMMA (Polymethylmethacrylate) Dispersion Solution

[0108] A dispersion was prepared in the same manner as Example 1, except that 14 g of polymethylmethacrylate (PMMA, molecular weight 350k, manufactured by Aldrich) was used instead of polyhydroxyalkanoate in the above dispersion preparation example 1.

[0109] The dry solid content of the manufactured dispersion was confirmed to be 18 wt% as a result of analysis, and the particle size distribution was confirmed to be D50 (volume) 0.6 ㎛ as a result of analysis.

[0110]

[0111] Dispersion Manufacturing Example 4. Preparation of Polylactic Acid (PLLA, Poly L-lactic acid) Dispersion Solution

[0112] A dispersion was prepared in the same manner as Example 1, except that 14 g of polylactic acid (PLLA, Poly L-lactic acid, molecular weight 100k, manufactured by Aldrich) was used instead of polyhydroxyalkanoate in the above dispersion preparation example 1.

[0113] The dry solid content of the manufactured dispersion was confirmed to be 18 wt% as a result of analysis, and the particle size distribution was confirmed to be D50 (volume) 1.2 ㎛ as a result of analysis.

[0114]

[0115] Dispersion Manufacturing Example 5. Preparation of Polystyrene Dispersion Solution

[0116] A dispersion was prepared in the same manner as Example 1, except that 14 g of polystyrene (PS, Polystyrene molecular weight 350k, manufactured by Aldrich) was used instead of polyhydroxyalkanoate in the above dispersion preparation example 1.

[0117] The dry solid content of the manufactured dispersion was confirmed to be 18 wt% as a result of analysis, and the particle size distribution was confirmed to be D50 (volume) 0.6 ㎛ as a result of analysis.

[0118] The above polystyrene has a structure without NH-groups or carbonyl groups, unlike the polymers of the present invention, and was therefore used to compare the effects of the present invention.

[0119]

[0120] Dispersion Manufacturing Example 6. Preparation of PHA Dispersion Solution Containing Organic UV Blocking Agent

[0121] A dispersion was prepared in the same manner as in the above Dispersion Preparation Example 2, except that ethylhexyl methoxycinnamate (OMC) was not used and 17.52 g of ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S) powder was used instead of OMC.

[0122] The dry solid content of the manufactured dispersion was confirmed to be 38 wt% as a result of analysis, and the particle size distribution was confirmed to be D50 (volume) 0.7 ㎛ as a result of analysis.

[0123]

[0124] 2. Preparation of cosmetic composition

[0125] Example 1.

[0126] A cosmetic composition was prepared by mixing 28.6 wt% of the dispersion prepared in the above Dispersion Preparation Example 1, 3.3 wt% of titanium dioxide (TiO2, TiO2 dispersion (water-soluble, 30%) manufactured by Agarbatti), 44.0 wt% of caprylic / capric triglyceride (MCT Oil), 2.0 wt% of phytosphingosine (PhSG, manufactured by Solus Biotech), 4.5 wt% of 1 mol lactic acid (Lactic Acid), 2.0 wt% of 1-2-hexanediol (Activonol-6), 1.8 wt% of bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S), 4.2 wt% of ethylhexyl methoxycinnamate (OMC), and the remainder of distilled water.

[0127]

[0128] Example 2. Preparation of cosmetic composition

[0129] A cosmetic composition was prepared by mixing 23.5 wt% of the dispersion prepared in the above dispersion preparation example 2, 3.3 wt% of titanium dioxide (TiO2, TiO2 dispersion (water-soluble, 30%), commercially available product Agarbatti (manufactured by Shinavit Co., Ltd.), 44.0 wt% of caprylic / capric triglyceride (MCT Oil), 2.0 wt% of phytosphingosine, 4.5 wt% of 1 mol lactic acid, 2.0 wt% of 1-2-hexanediol (Activonol-6), and the remainder of distilled water.

[0130]

[0131] Example 3. Preparation of cosmetic composition

[0132] In the above dispersion preparation example 2, a cosmetic composition was prepared in the same manner as in Example 2, except that the prepared dispersion was used in an amount of 35.3 wt% and titanium dioxide was used in an amount of 5.0 wt%.

[0133]

[0134] Example 4. Preparation of cosmetic composition

[0135] A cosmetic was manufactured using the same method as Example 1, except that the amount of bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S) was reduced to 0.9 wt% and the amount of ethylhexyl methoxycinnamate (OMC) was reduced to 2.1 wt%.

[0136]

[0137] Example 5. Preparation of cosmetic composition

[0138] A cosmetic was manufactured using the same method as Example 4, except that 33.3 wt% of the dispersion prepared in Example 3 was used.

[0139]

[0140] Example 6. Preparation of cosmetic composition

[0141] A cosmetic was manufactured using the same method as Example 4, except that 33.3 wt% of the dispersion prepared in Example 4 was used.

[0142]

[0143] Example 7. Preparation of cosmetic composition

[0144] A cosmetic was manufactured using the same method as Example 4, except that 33.3 wt% of the dispersion prepared in Example 5 was used.

[0145]

[0146] Example 8. Preparation of cosmetic composition

[0147] A cosmetic was manufactured in the same manner as in Example 1, except that 28.6 wt% of the dispersion manufactured in Example 1 was used, and 3.0 wt% of bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S) was used instead of bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S) and ethylhexyl methoxycinnamate (OMC).

[0148]

[0149] Example 9. Preparation of cosmetic composition

[0150] A cosmetic was prepared in the same manner as in Example 8, except that 3.0 wt% of ethylhexyl methoxycinnamate (OMC) was used instead of bis-ethylhexyloxyphenol methoxyphenyl triazine (TS, TINOSORB S).

[0151]

[0152] Example 10. Preparation of cosmetic composition

[0153] A cosmetic was prepared in the same manner as in Example 8, except that 3.0 wt% of methylenebis-benzotriazolyltetramethylbutylphenol (TM) was used instead of bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S).

[0154]

[0155] Example 11. Preparation of cosmetic composition

[0156] A cosmetic was manufactured in the same manner as in Example 8, except that 3.0 wt% of isoamyl p-methoxycinnamate (IMC) was used instead of bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S).

[0157]

[0158] Example 12. Preparation of cosmetic composition

[0159] A cosmetic was manufactured in the same manner as in Example 8, except that 3.0 wt% of homosalate (Parsol HMS) was used instead of bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S).

[0160]

[0161] Example 13. Preparation of a cosmetic composition

[0162] A cosmetic composition was prepared by adding 2.0 wt% of the dispersion prepared in Example 1 of Dispersion Preparation instead of water to the commercially available product, Celenin the young UV Moisture Milk.

[0163]

[0164] Example 14. Preparation of cosmetic composition

[0165] A cosmetic composition was prepared by adding 11.4 wt% of the dispersion prepared in Example 6 of Dispersion Preparation instead of water and bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S) to the commercially available product, Celenin the young UV Moisture Milk.

[0166]

[0167] Comparative Example 1. Preparation of cosmetic composition

[0168] A cosmetic was manufactured using the same method as Example 1, except that the dispersion prepared in Example 1 was not used.

[0169]

[0170] Comparative Example 2. Preparation of a cosmetic composition

[0171] In Comparative Example 1, a cosmetic was manufactured in the same manner as in Comparative Example 1, except that the amount of bis-ethylhexyloxyphenol methoxyphenyltriazine (TS, TINOSORB S) was reduced to 0.9 wt% and the amount of ethylhexyl methoxycinnamate (OMC) was reduced to 2.1 wt%.

[0172]

[0173] Comparative Example 3. Preparation of a cosmetic composition

[0174] In the above Example 8, a cosmetic was manufactured in the same manner as in the above Example 8, except that no dispersion was used.

[0175]

[0176] Comparative Example 4. Preparation of a Cosmetic Composition

[0177] In the above Example 9, a cosmetic was manufactured in the same manner as in the above Example 9, except that no dispersion was used.

[0178]

[0179] Comparative Example 5. Preparation of a Cosmetic Composition

[0180] In the above Example 10, a cosmetic was manufactured in the same manner as in the above Example 10, except that no dispersion was used.

[0181]

[0182] Comparative Example 6. Preparation of a cosmetic composition

[0183] In the above Example 11, a cosmetic was manufactured in the same manner as in the above Example 11, except that no dispersion was used.

[0184]

[0185] Comparative Example 7. Preparation of a Cosmetic Composition

[0186] In the above Example 12, a cosmetic was manufactured in the same manner as in the above Example 12, except that no dispersion was used.

[0187]

[0188] Comparative Example 8. Preparation of a Cosmetic Composition

[0189] I received and used a commercially available product called Celenin the young UV Moisture Milk.

[0190]

[0191] Experimental example

[0192] Experimental Example 1. Measurement of in vitro SPF and in vivo SPF / PA (Comparative Example 1, Examples 1 to 3)

[0193] In vitro SPF measurement method

[0194] Cosmetic formulations were applied to five polymethylmethacrylate (PMMA) plates at a concentration of 1.3 mg / cm2; nine measurements were taken per plate; Solar Light SPF-290AS, a device owned by the Korea Institute of Ceramic Engineering and Technology, was used.

[0195]

[0196] In vivo SPF / PA measurement method

[0197] The test was conducted by an external testing agency (Korea Institute of Dermatological Sciences, Seoul / SkinMed Clinical Trial Research Center, Daejeon) according to the standard UV protection factor measurement method (ISO24444:2019 / ISO24442:2011), and the results are shown in Table 1.

[0198] Composition INCI Name Comparative Example 1 Example 1 Example 2 Example 3 wt% wt% wt% wt% wt% AMCT Oil Caprylic / Capric Triglyceride 44.0 44.0 44.0 44.0 44.0 APhSG Phytosphingosine 2.0 2.0 2.0 2.0 2.0 Activonol-6 1,2-Hexanediol 2.0 2.0 2.0 2.0 ALactic acid (1 mol) Lactic acid 4.5 4.5 4.5 4.5 ATS Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 1.8 1.8 AOMC Ethylhexyl Methoxycinnamate 4.2 4.2 BTiO2 Dispersion (30%) Titanium dioxide; Water 1.02.31.02.31.02.31.53.5B Dispersion Preparation Example 1 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Water 5.01.022.6 B Dispersion Preparation Example 2 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; Ethylhexyl Methoxycinnamate; Water 5.01.01.84.211.57.51.52.76.317.3B Distilled water Add up to 100 Add up to 100 Add up to 100 Add up to 100 In vitro SPF 26 120118133 In vivo SPF 15 204452 In vivo PAPA++PA+++PA+++PA++++

[0199] As shown in the results in Table 1 above, it was confirmed that the in vitro SPF significantly increased in Examples 1 to 3 compared to Comparative Example 1 without PHA.

[0200] Comparing Comparative Example 1 and Example 1, it was confirmed that SPF increased slightly and PA increased significantly, and when comparing Comparative Example 1 and Example 2, it was confirmed that both SPF / PA of Example 3 increased significantly as the UV-blocking components TS or OMC were incorporated into PHA. This can be seen as because the organic UV-blocking components were incorporated into PHA, so they were not absorbed into the skin and their efficiency increased.

[0201] In addition, as in Example 3, SPF 50+ / PA++++ was achieved even with a small amount of inorganic and organic sunscreens, confirming that the effect of enhancing the UV protection factor in vivo is significant when the dispersion solution presented in the present invention is included.

[0202]

[0203] Experimental Example 2. Measurement of in vitro SPF and in vivo SPF / PA (Comparative Example 2, Examples 4 to 7)

[0204] In vitro SPF measurement method

[0205] Cosmetic formulations were applied to five polymethylmethacrylate (PMMA) plates at a concentration of 1.3 mg / cm2; nine measurements were taken per plate; Solar Light SPF-290AS, a device owned by the Korea Institute of Ceramic Engineering and Technology, was used.

[0206]

[0207] Composition INCI Name Comparative Example 2 Example 4 Example 5 Example 6 Example 7 wt% wt% wt% wt% wt% wt% AMCT Oil Caprylic / Capric Triglyceride 44.0 44.0 44.0 44.0 44.0 44.0 APhSG Phytosphingosine 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Activonol-6 1,2-Hexanediol 2.0 2.0 2.0 2.0 2.0 2.0 ALactic acid (1 mol) Lactic acid 4.5 4.5 4.5 4.5 4.5 4.5 ATS Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 0.9 0.9 0.9 0.9 0.9 0.9 AOMC Ethylhexyl Methoxycinnamate 2.12 12.12.12.1 BTiO2 Dispersion (30%) Titanium dioxide; water 1.02.31.02.31.02.31.02.31.02.3B Dispersion Preparation Example 1 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Water 5.01.022.6 B Dispersion Preparation Example 3 Polymethyl Methacrylate; Glycerin Stearate Citrate; Water 5.01.027.3 B Dispersion Preparation Example 4 Polylactic Acid; Glycerin Stearate Citrate; Water 5.01.027.3 B Dispersion Preparation Example 5 Polystyrene; Glycerin Stearate Citrate; Water 5.01.027.3B Distilled water Add up to 100 Add up to 100 Add up to 100 Add up to 100 Add up to 100 In a test tube SPF 1247414615

[0208] As shown in the results in Table 2 above, it was confirmed that the in vitro SPF significantly increased in Example 4 compared to Comparative Example 2, which did not contain PHA. In addition, it was confirmed that the SPF significantly increased in Examples 4 and 5, which contained PMMA and PLLA instead of PHA, compared to Comparative Example 2.

[0209] However, in Example 7, which used PS without NH- or carbonyl functional groups instead of PHA, the in vitro SPF did not increase compared to Comparative Example 2. Therefore, it can be seen that the functional group in the resin additive to be used is necessary for the in vivo UV protection factor enhancement effect to be significant. The molecular structures of the resin additives used in this test are presented in Table 3 below.

[0210] Resin Type INCI Name Molecular Structure PHA (Poly Hydroxy Alkanoate) Polyhydroxyalkanoate PMMA(Poly Methyl MethAcrylate) PLLA (Poly L-Lactic Acid) PS(Poly Styrene) polystyrene PEI (Poly Ethylen Imine)

[0211] Experimental Example 3. Comparison of the UV protection factor enhancement effects of PHA dispersions.

[0212] In vitro SPF measurement method

[0213] Cosmetic formulations were applied to five polymethylmethacrylate (PMMA) plates at a concentration of 1.3 mg / cm2; nine measurements were taken per plate; Solar Light SPF-290AS, a device owned by the Korea Institute of Ceramic Engineering and Technology, was used.

[0214] Composition INCI Name Comparative Example 3 (Placebo) Example 8 (Sample) Comparative Example 4 (Placebo) Example 9 (Sample) Comparative Example 5 (Placebo) Example 10 (Sample) Weight % Weight % Weight % Weight % Weight % Weight % AMCT Oil Caprylic / Capric Triglyceride 44.0 44.0 44.0 44.0 44.0 44.0 44.0 APhSG Phytosphingosine 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Activonol-6 1,2-Hexanediol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 ALactic acid (1 mol) Lactic acid 4.5 4.5 4.5 4.5 4.5 4.5 ATS Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 3.0 3.0 AOMC Ethylhexyl Methoxycinnamate 3.03.0 ATM Methylenebis-Benzotriazolyltetramethylbutylphenol 3.03.0BTiO2 Dispersion (30%) Titanium dioxide; Water 1.02.31.02.31.02.31.02.31.02.31.02.31.02.3B Dispersion Preparation Example 1 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Water 5.01.022.6 5.01.022.6 5.01.022.6B Distilled water Add up to 100 Add up to 100 Add up to 100 Add up to 100 Add up to 100 Add up to 100 In-vitro SPF 106 28 23 3 5 SPF Increase Rate * +520% +188% +67% * (Sample Value - Placebo Value) / Placebo Value X 100%

[0215] Composition INCI Name Comparative Example 6 (Placebo) Example 11 (Sample) Comparative Example 7 (Placebo) Example 12 (Sample) Weight % Weight % Weight % Weight % AMCT Oil Caprylic / Capric Triglyceride 44.0 44.0 44.0 44.0 44.0 APhSG Phytosphingosine 2.0 2.0 2.0 2.0 2.0 Activonol-6 1,2-Hexanediol 2.0 2.0 2.0 2.0 ALactic acid (1 mol) Lactic acid 4.5 4.5 4.5 4.5 AIMC Isoamyl p-methoxycinnamate 3.0 3.0 AParsol HMS Homosalate 3.0 3.0 BTiO2 Dispersion (30%) Titanium dioxide; Water 1.02.31.02.31.02.31.02.3B Dispersion Preparation Example 1 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Water 5.01.022.6 5.01.022.6B Distilled water Add up to 100 Add up to 100 Add up to 100 Add up to 100 SPF in test tube 92235 SPF increase rate * +144% +67% * (Sample value - Placebo value) / Placebo value X 100%

[0216] As shown in the results in Tables 4 and 5 above, when comparing the SPF change when PHA dispersion was added (sample, example) and when it was not added (placebo, comparative example) by type of organic sunscreen, it was found that the effect of strengthening the UV protection factor in the body was different depending on the type of organic sunscreen, and among them, it was confirmed that Example 8 including TS organic sunscreen showed the most significant effect. In addition, although the UV protection factor was strengthened in Example 10 including TM organic sunscreen and Example 12 including Parsol HMS organic sunscreen, it could not be considered to have a significant effect because the SPF value was low.

[0217] Therefore, when examining the UV protection factor enhancement effect of PHA dispersion, it was found that the effect was in the order of TS ≫ OMC > IMC > TM = Parsol HMS.

[0218]

[0219] Experimental Example 4. Comparison of UV protection index measured using the composition of the present invention as an additive to existing commercially available sunscreens.

[0220] In vitro SPF measurement method

[0221] Cosmetic formulations were applied to five polymethylmethacrylate (PMMA) plates at a concentration of 1.3 mg / cm2; nine measurements were taken per plate; Solar Light SPF-290AS, a device owned by the Korea Institute of Ceramic Engineering and Technology, was used.

[0222]

[0223] Composition INCI Name Comparative Example 8 Example 13 Example 14 wt% wt% wt% ACELENIN THE YOUNG UV Moisture Milk ATS Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 2.20 2.20 B Dispersion Preparation Example 1 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Water 0.41 0.08 1.51 B Dispersion Preparation Example 6 Polyhydroxyalkanoate; Glycerin Stearate Citrate; Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; Water 1.84 0.36 2.20 7.00 In vitro SPF 4 2 147 375 In vivo SPF 4 0 50 55 In vivo PA PA++ PA++++ PA++++

[0224] When the dispersion solution presented in the present invention was included in Celenin the young UV Moisture Milk, a commercial product containing various organic UV blockers, it was confirmed that both the in vitro SPF and the in vivo SPF / PA significantly increased, as shown in the results in Table 5 above. In addition, when the organic UV blocking ingredient TS contained in the commercial product Celenin the young UV Moisture Milk was changed to a dispersion solution containing PHA, the in vivo SPF significantly increased to 55, indicating that the UV blocking efficiency is further increased as described in Experimental Example 1.

[0225] In addition, since the SPF / PA is increased by adding only a small amount of the dispersion solution (dispersion preparation example 1) presented in this patent to a commercial product, it is expected that it can be universally applied as a UV protection booster when used as an additive to other sunscreen product groups.

Claims

1. A UV blocking efficacy booster composition comprising a polymer, A booster composition having UV protection efficacy, wherein the D50 (volume) of the polymer included in the above composition is 0.1 to 10 μm.

2. In paragraph 1, The above polymer is a biodegradable polymer, a UV blocking efficacy booster composition.

3. In paragraph 1, A UV-blocking efficacy booster composition, characterized in that the polymer has at least one functional group selected from the group consisting of an NH- group and a carbonyl group.

4. In paragraph 1, A UV-blocking efficacy booster composition, wherein the polymer is at least one selected from the group consisting of PHA (Poly hydroxyalkanoate), PBAT (Polybutylene adipate terephthalate), PBS (polybutylene succinate), PCL (polycaprolactone), PMMA (Poly methyl methacrylate), PLLA (Poly L-lactic acid), and PEI (Poly ethylene imine).

5. Containing polymers; and oils; D of the above polymer 50 A cosmetic composition having a volume of 0.1 to 10 μm.

6. In paragraph 5, A cosmetic composition characterized in that the polymer encapsulates a sunscreen ingredient.

7. In paragraph 5, A cosmetic composition, characterized in that the polymer is contained in an amount of more than 0 and less than 10 wt% relative to the total weight of the cosmetic composition.

8. In paragraph 5, A cosmetic composition wherein the polymer is a biodegradable polymer.

9. In paragraph 5, A cosmetic composition, characterized in that the polymer has at least one functional group selected from the group consisting of an NH group and a carbonyl group.

10. In paragraph 5, A cosmetic composition, wherein the polymer is at least one selected from the group consisting of PHA (Poly hydroxyalkanoate), PBAT (Polybutylene adipate terephthalate), PBS (polybutylene succinate), PCL (polycaprolactone), PMMA (Poly methyl methacrylate), PLLA (Poly L-lactic acid), and PEI (Poly ethylene imine).

11. In paragraph 5, The above cosmetic composition further comprises an organic dye other than the polymer, A cosmetic composition characterized in that the organic sunscreen is at least one selected from the group consisting of ethylhexyl methoxycinnamate (OMC), bis-ethylhexyloxyphenol methoxyphenyl triazine (TS), polysilicon-15, isoamyl p-methoxycinnamate, diethylaminohydroxybenzoylhexyl benzoate, ethylhexyl triazone, butyl methoxydibenzoylmethane, ethylhexyl salicylate, ethylhexyl cinnamate, homosalate, ethylhexyl triazone, and octocrylene.

12. In paragraph 5, A cosmetic composition characterized in that the above cosmetic composition is for blocking ultraviolet rays.

13. In paragraph 5, The composition is a cosmetic composition having a formulation selected from the group consisting of a solution, an ointment, an external ointment, a cream, an essence, a foam, a toner, a nourishing toner, an emollient, an emollient toner, a pack, an emulsion, a makeup base, a soap, a cleanser, a bath agent, a sunscreen, a sun oil, a suspension, an emulsion, a paste, a gel, a lotion, a powder, a soap, a cleansing agent containing a surfactant, an oil, a foundation, a powder foundation, an emulsion foundation, a wax foundation, a patch, and a spray.

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