Liquid spray plaster and wound protection method using same

Abstract

The group of inventions relates to chemistry, medicine and pharmaceutics, and more particularly to a liquid aerosol composition for the protection of wounds and to a wound protection method. The proposed liquid aerosol composition comprises a film-forming solution of a polymer in an organic solvent, and a propellant, wherein the film-forming solution consists of 2-5 wt.% styrene-ethylene-butylene-styrene (SEBS) block copolymer and 95-98 wt.% organic solvent selected from among dichloromethane, cyclohexane or a mixture thereof, and the propellant is a hydrocarbon propellant or dimethyl ether. According to the proposed method, the liquid aerosol composition is applied to the surface of a wound from a distance of 10-20 cm for 10-15 seconds by spraying from an aerosol can, wherein a polymer film is formed within 30-60 seconds and the formed polymer film has a thickness of 0.006-0.010 mm. The group of inventions provides an elastic film which has good adhesive properties and an optimal moisture vapour transmission rate.

Description

[0001] LIQUID AEROSOL PLASTER AND A METHOD OF PROTECTING A WOUND WITH ITS HELP

[0002] Field of technology

[0003] The invention relates to a medical device, namely to an aerosol composition for spraying film-forming solutions of synthetic polymers onto a wound surface in order to protect superficial wounds of various etiologies from mechanical damage and microbial contamination. In addition, the present invention relates to a method for protecting a wound using a liquid aerosol composition. The invention can be used in everyday life, cosmetology and minimally invasive surgery, in particular for protecting and accelerating the healing of superficial wounds, cuts, abrasions, scratches, mild burns, cracks, trophic ulcers, bedsores, after tattooing procedures, piercing, medical and aesthetic manipulations.

[0004] State of the art

[0005] The skin is an important barrier for the human body, protecting it from external influences. In everyday life, skin injuries are extremely common, such as skin abrasions, small cuts, minor burns, consequences of minor medical and aesthetic manipulations, local superficial wounds caused by accidents or diseases. The issue of traumatization and contamination of open wounds is a serious problem, especially in cases of increased risk of wound contamination.

[0006] The healing of small superficial wounds is often taken for granted, as it is assumed that in these cases the normal healing phases should proceed without any problems. However, small wounds also require proper care to prevent possible complications, particularly infection. The wound healing process can be disrupted by various external causes, as well as systemic diseases. In this case, wound healing can stop in the inflammatory phase, and disorders of proliferative and / or remodeling processes can also occur. Most symptoms associated with acute inflammatory processes during wound healing last about 2 weeks, however, if the inflammation persists for months or even years, this disorder leads to a chronic wound. Pathological changes in proliferative or remodeling processes often contribute to delayed and impaired healing.Some patients experience abnormal healing with the formation of scars or keloids that may extend beyond the original wound boundaries, which may lead to significant cosmetic defects (Korting H.C., Schollmann C., White R.J., Management of minor acute cutaneous wounds: importance of wound healing in a moist environment, J Eur Acad Dermatol Venereol, 2011 Feb;25(2):130-7. doi: 10.111 l / j.1468-3083.2010.03775.x. Epub 2010 Jul 6. PMID: 20626534).

[0007] In particular, the scientific literature describes cases of development of serious complications in hand injuries aggravated by an accompanying infection. Due to the anatomical features of the hand, rapid progression of initially unnoticeable infections can occur, leading to functional limitations (Enechukwu A.O.M., Wellkamp L., Vogt P.M., Krezdorn N., Infektionen der Hand und des Unterarms [Infections of the hand and forearm], Unfallchirurg. 2022 Jan;125(l):9-18. German, doi: 10.1007 / s00113-021-01106-3. Epub 2021 Nov 24. PMID: 34820739).

[0008] To care for the damaged skin barrier, medical dressings or plasters are used, which can play an important role in protecting the wound, preventing infection, and promoting wound healing. The medical dressings (plasters) used are not always able to effectively perform the barrier function for the wound surface, which can lead to secondary contamination of the wound surface of the skin, which in turn causes inflammation and prolongs the period of wound healing and restoration of the integrity of the skin barrier. Traditional dressings, such as absorbent cotton wool, gauze, etc., widely used in clinical practice today, have too much absorbency, which does not promote cell survival and tissue regeneration. Granulation tissue formed during wound healing is prone to adhesion to the dressing when replaced and secondary damage when removed.In addition, during use, they must be fixed with medical tape, the scope of application of which is relatively limited. Therefore, more and more researchers are paying attention to the development of new dressings. The optimal type of dressing is one that ensures that the wound remains moist, while the dressing must have good air permeability and perform a barrier function.

[0009] A number of studies dating back to the middle of the last century have shown that epidermal healing is enhanced in a moist wound environment compared to wounds exposed to open air. The benefits of maintaining a moist wound for the healing process are now well documented, and moist wound care has become the standard of care, particularly for chronic wounds with impaired healing (Korting H.C., Schollmann C., White R.J., Management of minor acute cutaneous wounds: importance of wound healing in a moist environment, J Eur Acad Dermatol Venereol, 2011 Feb;25(2): 130-7. doi: 10.1111 / j.l468-3083.2010.03775.x. Epub 2010 Jul 6. PMID: 20626534). A rather promising technological direction for the development of medical dressings has become liquid dressings or plasters - medical products produced in the form of solutions and / or emulsions, which, when applied to the skin, are capable of drying quickly, forming a protective film.The obvious advantages of such dressings or plasters are ease of application, convenience in treating wounds with uneven edges, as well as abrasions and cuts, in addition, the material of such dressings or plasters and the film they form often provide, along with protection, isolation from external influences, also an obstacle to excessive evaporation of wound exudate, thus creating optimal "wet" conditions for healing. At the same time, there are a number of disadvantages that limit the use of liquid dressings / plasters. Thus, the time of film formation (solvent evaporation) plays a significant role. If drying occurs for a long time (several minutes), the solution flows off the wound surface, not having time to form a dense protective film. In addition, one of the key characteristics of such dressings / plasters is vapor and gas permeability, which determine the modes of moisture evaporation from the wound surface and air access to it.In most liquid dressings / plasters, the film-forming component is a synthetic polymer and has too low vapor and gas permeability, which complicates wound healing due to the resulting “greenhouse” effect.

[0010] Liquid medical dressings / plasters produced in the form of aerosols are largely free of these disadvantages. The application of such dressings is much more convenient and simpler compared to solutions, aerosol spraying provides a high degree of dispersion of solution droplets, which allows for extremely rapid formation of a film on the wound surface (in a few seconds), as well as a small thickness of the formed film, providing optimal indicators of vapor and gas permeability.

[0011] The purpose of this invention is to solve the problem of accelerating the healing of and protecting against infection of superficial wounds, cuts, abrasions, scratches, mild burns, cracks, trophic ulcers, bedsores, after tattooing, piercing, medical and aesthetic procedures. Document CN114133480, 03 / 04 / 2022 describes a liquid polyacrylate dressing with a water-based antibacterial component and a method for its preparation. In addition to the antibacterial component (can be: cetyldimethylallylammonium chloride, octadecyldimethylallylammonium chloride, dimethyloctadecyl-3-trimethyl chloride, oligomeric salt of guanidine and chitosanguanidine), this dressing includes a silicon-containing additive, which is an alkoxysilane, alkylsiloxane, one or more peroxysilanes. The composition also includes an auxiliary agent comprising at least a polymerization initiator.

[0012] In some embodiments, the auxiliary agent additionally includes an emulsifier, as well as from 0.1 to 10 parts by weight of a rigid monomer, which is one or more compounds consisting of styrene, acrylonitrile and isobornyl methacrylate.

[0013] The advantages of the disclosed technical solution include: formation of an elastic film on the wound surface, good air permeability, antibacterial effect, and lack of irritating effect on the skin.

[0014] The disadvantages of this dressing include: the complexity of the composition and, accordingly, the technology of production, significantly different mechanical properties and permeability properties of the dressing in different versions, the structure-forming base of the dressing is formed by alginate gel, which has pronounced absorbent properties, which can lead to a violation of the natural water balance of the wound surface.

[0015] Document CN112274689, 29.01.2021, describes a liquid waterproof dressing and a method for producing it. The liquid dressing, in mass percentage, includes a film former of 6-16%, a tackifier of 0.5-3%, a plasticizer of 3-12%, a bacteriostatic of 0.5%-2%, and a solvent of 67-90%.

[0016] The film former is a mixture of polyvinyl alcohol and polyvinyl butyral, the mixing ratio is 0.5-1.0; phenolic resin and polyacrylic resin are used to increase stickiness; the plasticizer is a mixture of two or more diethyl / butyl phthalate, ethyl acetate, glycerin, rosin, propylene glycol and castor oil; the bacteriostatic agent is one or a mixture of two or more components consisting of ethylparaben, phenoxyethanol and chlorphenesin; the solvent is one type or a mixture of two types of isopropyl alcohol and absolute ethanol, while the mixing ratio of isopropyl alcohol and absolute ethanol is 0.5-1.0. Among the advantages of the invention are noted: the formation of an elastic film on the wound surface, good air permeability, antibacterial effect, no irritating effect on the skin

[0017] The disadvantages of this invention include: a significant time for film formation (up to 3 minutes), the use of phenolic resin in the composition, which can have a toxic effect when dry, and the application of the dressing in the form of a solution, which limits the scope of its application.

[0018] Document CN111184906, 05 / 22 / 2020, discloses a liquid dressing and a method for preparing it. The dressing contains: 1,2-epoxy-4-vinylcyclohexane, polyvinyl alcohol, xanthan gum, glycerin, ethanol, water and an antibacterial component.

[0019] The advantages of the invention include: formation of an elastic film on the wound surface, transparency, good vapor permeability, antibacterial effect, no irritating effect on the skin.

[0020] The disadvantages of this invention include: possible foam formation during the preparation of the solution, requiring an additional technological stage of foam suppression, significant film formation time (up to 20 minutes), the use of glycerin in the composition, which has a water-absorbing effect, which can lead to overdrying of the wound, application of the dressing in the form of a solution, which limits the scope of its application.

[0021] Document CN108144105, 12.06.2018, discloses an invention in the form of a liquid dressing and is intended for wound disinfection. The following materials were used for production: 0.1-0.2 parts povidone iodine, 0.1-0.3 parts polyhexamethylene biguanide, 0.1-0.3 parts potassium chloride, 1-3 parts sodium carbonate, deionized, 93-95 parts water, 2-3.5 parts hyaluronic acid powder, 4-6 parts triethanolamine, 6-9 parts witch hazel, 3-7 parts houttuynia cordata, 3-5 parts coix seeds, 6-8 parts myristic aldehyde, 4-7 parts perfluorocarboxylate.

[0022] The following are named among the advantages: absence of hormones in the composition, the ability to disinfect and promote wound healing.

[0023] The disadvantages of this invention include the suboptimal mechanical properties of hydrogels formed by hyaluronic acid, their low stability on the wound surface, and high degradation rate.

[0024] Document CN111588903, 08 / 28 / 2020, discloses an invention consisting of a liquid dressing for skin barrier care and restoration, as well as a method for its preparation. Each 1000 g of the liquid dressing contains: 25-38 g of pentylene glycol, 15-25 g of glycerin, 15-25 g of carboxymethyl dextran and 1-8 g of sodium hyaluronate, 15-25 g of yeast essence, 6-10 g of plant compound fermentation filtrate and 0.5-2 g of ethyl parahydroxybenzoate.

[0025] The advantages of the invention include: stimulation of the skin system immunity and the function of skin barrier restoration due to the combination of yeast essence, carboxymethyldextran, with sodium hyaluronate; provision of an optimal environment for wound healing and cell proliferation due to the inclusion of plant compounds in the fermentation filtrate.

[0026] The disadvantages of this invention include: non-optimal mechanical properties characteristic of hydrogels; the dressing material is a favorable environment for the development of microorganisms; the content of products of biological origin, increasing the risk of secondary contamination of the wound.

[0027] The closest technical solution (prototype) to the claimed object is disclosed in patent No. RU2312658, 20.12.2007, namely, a film-forming aerosol for protecting wounds during treatment is described, based on a synthetic polymer, characterized in that it consists, in parts by weight, of: 1) polysiloxane-polycarbonate block copolymer / PS-PC / with a ratio of PS:PC blocks = (35-55): (65-45), as a base for forming a coating film 3-10; 2) chloroform - a solvent for the block copolymer and as an anesthetic substance 97-90; 3) an antiseptic preparation in an alcohol solution 0.1-0.2; 4) a halogenated hydrocarbon or a mixture thereof as a propellant 100-120. A method of using the aerosol is also described.

[0028] The advantages of the invention include: tight fixation of the protective coating, which does not require any disinfection of the sprayed aerosol films, ensures high speed and ease of application of medical and protective polymer layers.

[0029] The disadvantages of this invention include: chloroform included in the composition, which when interacting with wet skin (wound surface) causes a burning sensation, this component also belongs to narcotic substances, the presence of halogenated hydrocarbons in the propellant, which pose a danger to the environment (ozone layer) and are expensive.

[0030] The proposed invention is aimed at eliminating the shortcomings of the above-mentioned known technical solutions.

[0031] The proposed invention differs from the prototype in several respects: the invention uses a different composition of film-forming and auxiliary substances on a polymer based on SEBS block copolymer, which forms a film with improved mechanical characteristics and moisture and gas exchange indicators; a mixture of organic solvents is used, which has low toxicological indicators and does not have a narcotic effect; a hydrocarbon propellant is used, which is safe for the ozone layer, in addition, the time of film formation on the wound surface upon application is 30-60 seconds.

[0032] Disclosure of the essence of the invention

[0033] The objective of the claimed invention is to create an effective liquid aerosol patch, devoid of the above-mentioned drawbacks and satisfying the requirements for these medical products. As a result of the studies, an aerosol patch of the following composition was developed, wt.%: polymer based on SEBS block copolymer - 2-5%; a mixture of organic solvents methylene chloride and / or cyclohexane and / or n-hexane - 95-98%

[0034] A polymer solution in an organic solvent and propellant are packaged in an aluminum aerosol can, equipped with a valve, a spray head and a protective cap.

[0035] Composition of the working solution in an aerosol can:

[0036] Liquid patch - 30-33%;

[0037] Hydrocarbon propellant and / or dimethyl ether - 67-70%

[0038] The polymer used in this composition based on SEBS block copolymer is SEBS (styrene-ethylene-butylene-styrene block copolymer), a modifier of thermoplastic materials, produced in the form of granules.

[0039] Preferably, the molecular weight of the SEBS block copolymer, expressed as Mreac, is in the range of 350,000 to 475,000 g / mol.

[0040] It is also possible to use methylene chloride and n-hexane in a 1:1 ratio as a solvent mixture.

[0041] Any known hydrocarbon propellant can be used as a propellant, for example, hydrocarbon propellant grade “A” according to TU 027239-002-43148658-2006 or aerosol propellant gas GVAU (GRAP)® TU 19.20.31-002.43148658-2018.

[0042] In one embodiment of the invention, it is possible to add dimethyl ether (DME) as a propellant, for example, liquid dimethyl ether according to TU 20.14.63-052-05761695-2017. In addition, according to the present invention, a method for protecting a wound using the developed liquid aerosol patch is proposed. The liquid patch is applied from an aerosol can from a distance of 10-20 cm from the treated skin surface until the wound is completely covered with a polymer solution (usually within 10-15 seconds). The propellant released under pressure from the aerosol can disperses the polymer solution and delivers the dispersion to the site of application. After contact with the skin, the solvent actively and completely evaporates within 30-60 seconds. A thin elastic waterproof film is formed, protecting the damaged surface from microbial infections, fungi and mechanical impact.The patch reduces pain due to the cooling effect of the solvent evaporation, maintains the natural balance of the skin, allows it to breathe and promotes its rapid regeneration. The patch is stable on the skin for 6-8 hours, does not require removal without special need, because it degrades along with the natural process of exfoliation of the keratinized epithelium of the skin.

[0043] The resulting film has a thickness of 0.006-0.010 mm and has the following characteristics: average tensile strength of 1.493 N / mm2; average tear strength of 1.557 N / mm2; average relative elongation at maximum load of 491.67%; average relative elongation at break of 498.50%; average peel force (adhesive properties) of 31.36 N / m; average vapor permeability for 24 hours of 14.2 kg / m2.

[0044] Thus, the technical result of the claimed invention consists in the formation within 30-60 seconds on the wound surface of a thin (0.006-0.010 mm thick), elastic film with good adhesive properties, possessing optimal vapor permeability to maintain “wet” wound healing and, at the same time, reducing the risk of the “greenhouse” effect.

[0045] The method proposed in the present invention is also applicable for protection against cuts, abrasions, scratches, mild burns, cracks, trophic ulcers, bedsores, after tattooing, piercing, medical and aesthetic procedures.

[0046] Examples of obtaining a patch.

[0047] Example 1

[0048] To prepare the working solution (liquid patch), only short-term dissolution in a mixture of organic solvents at room temperature is required. Example of obtaining a liquid aerosol dressing: 1 g of SEBS block copolymer was dissolved for 30 minutes with constant stirring and a temperature of 25 °C in a mixture of solvents (methylene chloride and cyclohexane in a ratio of 1: 1, total volume of 22 ml). Then the resulting solution was placed in an aerosol can with a capacity of 100 ml, the valve was pressurized and, using an aerosol production unit, 48.8 ml of propellant (hydrocarbon mixture) was placed into the can through the valve. A sprayer and a protective cap were installed.

[0049] Example 2

[0050] 0.98 g of SEBS block copolymer was dissolved in 22 ml of methylene chloride for 30 minutes with constant stirring and a temperature of 25°C. The resulting solution was then placed in a 100 ml aerosol can, the valve was pressurized, and 48.8 ml of propellant (hydrocarbon mixture) was placed into the can through the valve using an aerosol production unit. A sprayer and a protective cap were installed.

[0051] Example 3

[0052] 1.12 g of SEBS block copolymer was dissolved for 30 minutes with constant stirring and a temperature of 25°C in cyclohexane (volume 22 ml). Then the resulting solution was placed in an aerosol can with a capacity of 100 ml, the valve was pressed and 48.8 ml of propellant (dimethyl ether) was placed into the can through the valve using an aerosol production unit. A sprayer and a protective cap were installed.

[0053] Results of the conducted research.

[0054] Comparison of the strength characteristics of polymer films formed by the polymer according to the invention without filling the cylinder

[0055] During comparative studies of the formed polymer film when applying the polymer solution from a can and by evaporating the solvent from the polymer solution without using an aerosol can, it was found that the strength characteristics of the films are very similar with the same thickness and size of the films, while obtaining films of specified sizes without using cans is simpler and more reproducible during the course of the studies. Therefore, further studies of the films during stretching, tearing, as well as studying the adhesive properties were carried out without using aerosol cans.

[0056] 1 ml of the polymer solution was applied to a 2.5 x 5 cm cover glass, kept at room temperature for 30 minutes until the solvent completely evaporated, then the polymer film was carefully separated from the cover glass and placed in a tensile testing machine. The central section of the formed film measuring 2.5 x 3 cm was tested.

[0057] Polymer films formed by applying polymer solutions in methylene chloride (two concentrations under study); in a mixture of methylene chloride and cyclohexane 1:1 (polymer solutions with and without washing were studied). It was found that the strength characteristics of films formed by polymers with and without washing do not differ statistically significantly, therefore, Table 1 shows the combined measurement results for these solutions.

[0058] The study of the coefficient of extension and tensile strength for a given film thickness was conducted. The research methodology was adapted from GOST 14236-81.

[0059] The results of the research are presented in Table 1.

[0060] Table 1. Strength characteristics of polymer films

[0061] Additional observations: the thickness of the film formed when using methylene chloride as a solvent varies significantly both when applied from a can and when applied to glass with subsequent evaporation of the solvent, which leads to a significant spread in the values ​​of strength characteristics. The main reasons for the uneven thickness of the film are the fairly high viscosity of the polymer solution and, to a greater extent, the formation of air bubbles during active evaporation of the solvent - the thickness of the film in the bubble area can be 2-2.5 times greater than the average thickness of the rest of the film.

[0062] When cyclohexane and a mixture of cyclohexane and methylene chloride are used as solvents, the solvent evaporation rate is somewhat lower and fewer air bubbles are formed. Although the viscosity-related variability of film thickness is preserved, the film thickness values ​​are more uniform and the strength characteristics have fewer differences in the measurement series.

[0063] The polymer film obtained after evaporation of a 1:1 methylene chloride-cyclohexane solvent mixture demonstrated slightly lower tensile and tear strength, but a significantly higher average relative elongation.

[0064] Additional study. Determination of adhesive properties of polymer films formed by SEBS block copolymer without balloon filling

[0065] The tests were carried out using the adapted method “resistance to peeling of the adhesive layer” GOST R 53498 - 2019 at an angle of 90 degrees.

[0066] 1 ml of the polymer solution was applied to a 2.5 x 7 cm glass slide, kept at room temperature for 30 minutes until the solvent had completely evaporated, then the edge of the polymer film was carefully separated from the glass and placed in the clamp of the testing machine. The central section of the formed film measuring 2.5 x 5 cm was tested. The peeling speed was set according to the GOST method 300 ± 30 mm / min.

[0067] The results of the research are presented in Table 2.

[0068] Table 2. Adhesive characteristics of polymer films

[0069] All the studied films demonstrate similar and sufficiently high peel resistance values.

[0070] Comparison of vapor permeability of polymer films formed by polymers after application from a can

[0071] For the study, SEBS block copolymer films were obtained by applying them from aerosol cans from a distance of 20 cm onto the surface of the measuring device for 5 seconds; measurements were taken after the solvent evaporated.

[0072] A study of vapor permeability was conducted for the given film thickness. The research methodology was an adapted version of GOST 21472-81. The research results are presented in Table 3.

[0073] Table 3. Vapor permeability of polymer films

[0074] Conducting a study of the stability of the obtained samples using the accelerated aging method

[0075] Stability tests using the "accelerated aging" method were conducted in accordance with OFS.1.1.0009.15 "Shelf life of medicinal products". The samples under study were placed in a constant climatic conditions chamber at a constant temperature of +50 °C for 47 days. The strength characteristics and vapor permeability of polymer films were studied at the beginning of the study before loading the samples into the chamber, as well as after 15, 30 and 47 days.

[0076] Study of the strength characteristics of polymer films obtained from test samples of aerosols after testing using the "accelerated aging" method

[0077] To obtain a polymer film, the aerosol was sprayed from a canister from a distance of 10 cm for 5-6 seconds onto a 2.5x5 cm cover glass, kept at room temperature until the solvent completely evaporated, then the polymer film was carefully separated from the cover glass and placed in a tensile testing machine. The central section of the formed film measuring 2.5x3 cm was tested.

[0078] The study of the coefficient of extension and tensile strength for a given film thickness was conducted. The research methodology was adapted from GOST 14236-81.

[0079] The results of the studies are presented in Tables 4-6.

[0080] Table 4. Strength characteristics of polymer films after testing using the “accelerated aging” method (15 days)

[0081] Table 5. Strength characteristics of polymer films after testing using the “accelerated aging” method (30 days)

[0082] Table 6. Strength characteristics of polymer films after testing by the method

[0083] "accelerated aging" (47 days)

[0084] As a result of the conducted studies, it was established that the studied polymer films with methylene chloride solvent and cyclohexane (1:1) after the "accelerated aging" test generally retain their strength characteristics at the same or comparable to the previous level. When studying samples with methylene chloride solvent, the obtained data showed a significant decrease in the indicators of all the studied characteristics.

[0085] Study of vapor permeability of polymer films obtained from test samples of aerosols after conducting a test using the "accelerated aging" method

[0086] For the study, SEBS block copolymer films were obtained by applying them from aerosol cans from a distance of 20 cm onto the surface of the measuring device for 5 seconds; measurements were taken after the solvent evaporated.

[0087] A study of vapor permeability for a given film thickness was conducted. The research methodology was an adapted version of GOST 21472-81.

[0088] The results of the studies are presented in Tables 7-9.

[0089] Table 7. Vapor permeability of polymer films after the test using the “accelerated aging” method (15 days)

[0090] Table 8. Vapor permeability of polymer films after the test using the “accelerated aging” method (30 days) Table 9. Vapor permeability of polymer films after the test using the “accelerated aging” method (47 days)

[0091] All the samples tested after the "accelerated aging" test showed vapor permeability values ​​comparable to the initial values ​​of this indicator. Noteworthy is a slight increase in vapor permeability in samples with the solvent methylene chloride: cyclohexane (1:1).

[0092] The successful use of the proposed aerosol composition for protecting household wounds can be illustrated by clinical examples:

[0093] Example 1.

[0094] Patient S., 45, received a cut in the arch of the plantar part of her foot while swimming. The wound was bleeding moderately. After the bleeding stopped, a liquid aerosol plaster was applied to the wound area. The cooling effect of the solvent evaporation reduced the pain sensation. Within 20 seconds, a thin elastic waterproof film of uniform thickness formed on the surface of the damaged skin, which effectively protected against contamination by microorganisms (bacteria / fungi). The aerosol plaster reduced the contact mechanical effect (pressure, friction) of shoes on the wound surface, thereby further reducing the pain symptom. Given the localization of the wound surface (arch of the plantar part of the foot), fixation and use of standard plasters was difficult due to the complex relief and mobility of the skin in the wound area when walking.

[0095] In dynamics, repeated application of the liquid aerosol patch was carried out 1-2 times a day for 3 days depending on the volume of walking on the current day. Due to the optimal parameters of vapor permeability of the aerosol patch, a "greenhouse" effect was not created under it and the natural balance of the skin was maintained, which contributed to the rapid regeneration of damaged skin. By the 3rd day, the wound surface was completely healed, there were no exudation phenomena, signs of bacterial infection, which did not require further treatment.

[0096] Thus, the use of a liquid aerosol patch in the present clinical case for a cut provided the stated cooling effect, alleviating the pain symptom, protecting the wound from contamination by microorganisms (bacteria / fungi), protecting from mechanical impact, maintaining favorable conditions for skin regeneration, which in total was clinically confirmed by the optimal period (3 days) of healing of the wound surface, proceeding without any bacterial complications.

[0097] Example 2.

[0098] Patient R., 12 years old, received a deep abrasion in the area of ​​the extensor surface of the right knee joint when falling. The wound was bleeding moderately. After the bleeding stopped, a liquid aerosol plaster was applied to the wound area; the cooling effect of the solvent evaporation reduced the sensation of pain; within 20 seconds, a thin elastic waterproof film of uniform thickness formed on the surface of the damaged skin, which effectively protected against contamination by microorganisms (bacteria / fungi). The aerosol plaster reduced the contact mechanical effect (pressure, friction) of clothing on the wound surface, thereby further reducing the pain symptom. Given the localization of the wound surface (extensor surface of the right knee joint), fixation and use of standard plasters was difficult due to the complex relief and mobility of the skin in the wound area when walking.

[0099] In dynamics, repeated application of the liquid aerosol patch was carried out 1-2 times a day for 3 days. Due to the optimal parameters of vapor permeability of the aerosol patch, a "greenhouse" effect was not created under it and the natural balance of the skin was preserved, which contributed to the rapid regeneration of the damaged skin. By the 3rd day, the wound surface was completely healed, there were no exudation phenomena, signs of bacterial infection, which did not require further treatment.

[0100] Thus, the use of a liquid aerosol patch in the present clinical case of paresis provided the stated cooling effect, alleviating the pain symptom, protecting the wound from contamination by microorganisms (bacteria / fungi), protecting from mechanical impact, maintaining favorable conditions for skin regeneration, which in total was clinically confirmed by the optimal period (3 days) of healing of the wound surface, proceeding without any bacterial complications.

[0101] Example 3.

[0102] Patient M., 74, received a cut in the area of ​​the distal phalanx of the index finger of the left hand while preparing food. The wound was bleeding moderately. After the bleeding stopped, a liquid aerosol plaster was applied to the wound area; the cooling effect of the solvent evaporation reduced the sensation of pain; within 20 seconds, a thin elastic waterproof film of uniform thickness formed on the surface of the damaged skin, which effectively protected against contamination by microorganisms (bacteria / fungi). The aerosol plaster reduced the contact mechanical effect (pressure) on the wound surface, thereby further reducing the pain symptom. Given the localization of the wound surface (distal phalanx of the index finger), fixation and use of standard plasters was difficult due to the complex relief of the damaged area.

[0103] In dynamics, repeated application of the liquid aerosol patch was carried out 1-2 times a day for 3 days. Due to the optimal parameters of vapor permeability of the aerosol patch, a "greenhouse" effect was not created under it and the natural balance of the skin was preserved, which contributed to the rapid regeneration of the damaged skin. By the 3rd day, the wound surface was completely healed, there were no exudation phenomena, signs of bacterial infection, which did not require further treatment.

[0104] Thus, the use of a liquid aerosol patch in the present clinical case for a cut provided the stated cooling effect, alleviating the pain symptom, protecting the wound from contamination by microorganisms (bacteria / fungi), protecting from mechanical impact, maintaining favorable conditions for skin regeneration, which in total was clinically confirmed by the optimal period (3 days) of healing of the wound surface, proceeding without any bacterial complications.

[0105] The invention has been disclosed above with reference to a specific embodiment thereof. Other embodiments of the invention may be obvious to specialists, but do not change its essence as disclosed in the present description. Accordingly, the invention should be considered not limited in scope by the description and examples provided.

Claims

Invention formula 1. A liquid aerosol composition for wound protection, comprising a film-forming solution of a polymer in an organic solvent and a propellant, characterized in that the film-forming solution of the polymer in the organic solvent consists of 2-5 wt.% of a polymer, which is a styrene-ethylene-butylene-styrene (SEBS) block copolymer, and 95-98 wt.% of an organic solvent selected from methylene chloride, cyclohexane or a mixture thereof, wherein the propellant is selected from a hydrocarbon propellant or dimethyl ether.

2. A liquid aerosol composition according to item 1, characterized in that the organic solvent is a mixture of methylene chloride and cyclohexane in a volume ratio of 1:

1.

3. A method for protecting a wound, characterized in that a liquid aerosol composition according to paragraph 1 is applied to the surface of the wound from a distance of 10-20 cm for 10-15 seconds by spraying it from an aerosol can, wherein the formation of a polymer film occurs within 30-60 seconds, and the resulting polymer film has a thickness of 0.006-0.010 mm.