Composition containing lipid peptide and sucrose ester

Abstract

[Problem] To provide a novel composition which contains a lipid peptide and a sucrose ester that comprises a contamination suppressing effect and a penetration enhancing effect. [Solution] This composition contains: a lipid peptide-type compound in which a peptide moiety formed by the repetition of at least two or more identical or different amino acids is bonded to a lipid moiety that is composed of an aliphatic group having 10-24 carbon atoms; a sucrose ester; a 1,2-alkanediol; a fatty acid; and water.

Description

Compositions Comprising Lipid Peptides and Sucrose Esters

[0001] The present invention relates to a composition comprising a lipid peptide and a sucrose ester.

[0002] Lipid peptides are used as excellent gelling agents in view of the high safety and biocompatibility required for medical and cosmetic applications (Patent Document 1).

[0003] In recent years, new functions have been discovered, such as anti-fouling effects (Patent Document 3) and penetration-promoting effects (Patent Document 4), due to films formed by lipid peptides (Patent Document 2), and the usefulness of lipid peptide-containing compositions has increased in medical, cosmetic, and other applications.

[0004] Patent No. 5700222 International Publication No. 2020 / 004649 International Publication No. 2021 / 132653 International Publication No. 2021 / 132668

[0005] Conventional lipid peptide-containing compositions tend to precipitate or sediment over time at low temperatures or room temperature, making it difficult to maintain dispersion stability. Therefore, the object of the present invention is to provide a new lipid peptide composition that can be used safely and securely, prevents adhesion of particulate matter and the like at least at a level equivalent to that of conventional lipid peptide compositions, and has the effect of preventing contamination of skin, hair, clothing, or paper by these substances and the effect of promoting the penetration of the composition into skin, hair, clothing, or paper, while also having high dispersion stability at low temperatures or room temperature.

[0006] The present inventors have found that the above-mentioned object can be achieved by a composition containing at least one lipid peptide-type compound, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water, and have completed the present invention.

[0007] That is, in a first aspect, the present invention relates to a composition containing a lipid peptide-type compound in which a peptide moiety formed by repeating at least two or more identical or different amino acids is bound to a lipid moiety consisting of an aliphatic group having 10 to 24 carbon atoms, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water. In a second aspect, the present invention relates to the composition according to the first aspect, in which the sucrose ester is sucrose polystearate or sucrose stearate. In a third aspect, the present invention relates to the composition according to the first or second aspect, in which the 1,2-alkanediol is 1,2-pentanediol or 1,2-hexanediol. In a fourth aspect, the present invention relates to the composition according to any one of the first to third aspects, in which the lipid peptide-type compound comprises at least one of compounds represented by the following formulas (1) to (3) or pharmaceutically usable salts thereof: (In the formula, R １ represents an aliphatic group having 9 to 23 carbon atoms; R ２ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R ３ Ha-(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. (In the formula, R ４ represents an aliphatic group having 9 to 23 carbon atoms; R ５ ~R ７ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. (In the formula, R ８represents an aliphatic group having 9 to 23 carbon atoms; R ９ ~R １２ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２(R) represents a group, or a 5- or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5- and a 6-membered ring.) In a fifth aspect, the present invention relates to the composition according to any one of the first to fourth aspects, in which the fatty acid is stearic acid. In a sixth aspect, the present invention relates to the composition according to any one of the first to fifth aspects, in which the content of the lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition. In a seventh aspect, the present invention relates to the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide type compound is 0.001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition, the content of the sucrose ester is 0.0005% by mass or more and 0.25% by mass or less, relative to the total mass of the composition, the content of the 1,2-alkanediol is 0.0014% by mass or more and 0.7% by mass or less, relative to the total mass of the composition, and the content of the fatty acid is 0.0001% by mass or more and 0.05% by mass or less, relative to the total mass of the composition, and the composition is a transparent dispersion at a temperature of 0° C. or more and 40° C. or less. In an eighth aspect, the present invention relates to the composition according to the seventh aspect, wherein the lipid peptide type compound is palmitoyl-Gly-His. In a ninth aspect, the present invention relates to the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide type compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition. In a tenth aspect, the present invention provides a composition comprising a composition having a lipid peptide type compound content of 4.0% by mass or more and 6.0% by mass or less, the sucrose ester content of 2.0% by mass or more and 3.0% by mass or less, the 1,2-alkanediol content of 5.6% by mass or more and 8.4% by mass or less, the fatty acid content of 0.4% by mass or more and 0.6% by mass or less, and a breaking strength of 2.0 to 4.0 × 10 ５The present invention relates, in an eleventh aspect, to the composition according to the tenth aspect, in which the lipid peptide compound is palmitoyl-Gly-His. The present invention, in a twelfth aspect, to a cosmetic comprising the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide compound is 0.0001 mass % or more and 5.0 mass % or less, relative to the total mass of the cosmetic. The present invention, in a thirteenth aspect, to a method for reducing hair damage, comprising the steps of applying the cosmetic according to the twelfth aspect to hair, and forming a film. The present invention, in a fourteenth aspect, to a method for improving the water resistance of hair, comprising the steps of applying the cosmetic according to the twelfth aspect to hair, and forming a film. The present invention, in a fifteenth aspect, to the method according to the thirteenth or fourteenth aspect, in which the lipid peptide compound is palmitoyl-Gly-His. In a sixteenth aspect, the present invention relates to a method for producing the composition according to any one of the first to fifth aspects, comprising the steps of mixing the components of the composition according to any one of the first to fifth aspects and stirring at room temperature or with heating so that the content of the lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition, and allowing the mixture to cool and obtain a solid composition. In a seventeenth aspect, the present invention relates to a method for producing a dispersion of a lipid peptide compound, comprising the steps of: mixing the components of the composition according to any one of the first to fifth aspects and stirring at room temperature or with heating to produce a composition having a content of the lipid peptide compound of 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; and mixing the composition with water and stirring at room temperature or with heating so that the content of the lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less, to produce a liquid composition. In an eighteenth aspect, the present invention relates to a method for producing a cosmetic preparation, comprising the steps of:a step of mixing the components of the composition according to any one of the first to fifth aspects and stirring at room temperature or with heating to produce a composition in which the content of the lipid peptide type compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; a step of storing the resulting composition at room temperature or at a low temperature; a step of mixing the composition with water and stirring at room temperature or with heating so that the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, and storing the resulting composition at room temperature or at a low temperature; and a step of mixing the composition with water, various solvents, and other additives without heating, and stirring at room temperature or at a low temperature to produce a cosmetic in which the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, relative to the total mass of the cosmetic. The present invention relates to a method for promoting penetration of an active ingredient, comprising: a step of mixing the components of the composition according to any one of the first to fifth aspects and stirring the mixture at room temperature or under heating to produce a composition having a content of the lipid peptide compound of 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; a step of storing the obtained composition at room temperature or a low temperature; and a step of heating the composition, mixing it with various solvents and other additives, and stirring the mixture to obtain a cosmetic product such that the content of the lipid peptide compound is 0.0001% by mass or more and 5.0% by mass or less, relative to the total mass of the cosmetic product. The present invention relates, in a twentieth aspect, to a method for promoting penetration of an active ingredient, comprising a film-forming step of forming a film on the skin epidermis or hair surface comprising the composition according to the sixth aspect. The present invention relates, in a twenty-first aspect, to a method for promoting penetration of an active ingredient, comprising a film-forming step of forming a film on the skin epidermis or hair surface comprising the composition according to the ninth aspect. The present invention relates, in a twenty-second aspect, to a method for promoting penetration of an active ingredient, comprising a film-forming step of forming a film on the skin epidermis or hair surface comprising the composition according to the twelfth aspect.

[0008] According to the present invention, the lipid peptide compound used in the present invention is an extremely safe, artificial low-molecular-weight compound composed only of lipids and peptides. Furthermore, the lipid peptide composition of the present invention, which contains the specific lipid peptide compound, sucrose ester, 1,2-alkanediol, fatty acid, and water, can provide excellent effects on biological samples, including skin and hair, similar to conventional lipid peptide compositions. Specifically, the composition can form a lipid peptide film on the surface of skin, hair, clothing, or paper. This film prevents the adhesion of dust, pollen, particulate matter, and the like, and can prevent contamination of skin, hair, clothing, or paper by these substances. Furthermore, this film can protect skin, hair, clothing, or paper from UV damage. Furthermore, the formation of the film can promote penetration of the composition into skin, hair, clothing, or paper. Furthermore, the formed film repairs hair, thereby improving its humidity resistance, suppressing frizz, improving firmness and body, and imparting manageability and suppleness. Furthermore, in addition to having anti-fouling and penetration-enhancing effects, the lipid peptide composition of the present invention provides a novel lipid peptide composition that is highly safe to living organisms and can be used safely and securely. Therefore, the composition of the present invention is extremely useful from the perspective of the high level of safety required for pharmaceutical and cosmetic applications. Furthermore, the present invention provides compositions containing lipid peptide compounds at various concentrations. These compositions not only have the above-mentioned safety characteristics, but also exhibit unique effects depending on their respective concentrations. When the lipid peptide compound is present in an amount of 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition, the composition is uniformly dispersed in a liquid state at low or room temperature without precipitation or sedimentation over time, resulting in a dispersion with high dispersion stability. The dispersion can be mixed with other solvents and additives at room or low temperatures without heating, allowing further processing and easy handling. Furthermore, because the composition of the present invention, which is a dispersion, can maintain a stable dispersion state, it can be provided as a composition with excellent usability and appearance, for example, in pharmaceutical and cosmetic applications.When the lipid peptide compound is present in an amount of 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition, the composition becomes a white solid at room temperature, making it easier to store than a liquid, saving storage space and improving transportation efficiency. Furthermore, the dilution rate can be adjusted to suit the user's needs. Furthermore, the hardness of the solid can be adjusted by selecting an appropriate sucrose ester. A low hardness has the advantage of making it easier to scoop during weighing, while a high hardness prevents collapse during transportation. When the lipid peptide compound is present in an amount of 0.0001% by mass or more and 5.0% by mass or less relative to the total mass of the composition, a small amount of the lipid peptide compound is incorporated into the composition, but the composition can form an extremely thin lipid peptide film, which can provide anti-fouling and penetration-enhancing effects in a thin film. Furthermore, by selecting an appropriate sucrose ester, the moisture penetration of the formed film can be adjusted. Higher penetration enhances moisturizing effects and penetration-enhancing effects of active ingredients, while lower penetration enhances waterproofing effects. Furthermore, according to the present invention, a cosmetic containing a lipid peptide compound in an amount of 0.0001% by mass or more and 5.0% by mass or less relative to the total mass obtained by diluting a lipid peptide composition can form an extremely thin lipid peptide film on the surface of skin, hair, clothing, or paper, making it suitable for daily use.

[0009] Figure 1 is a graph showing the amount of nicotinamide permeation extracted from a three-dimensional cultured epidermal model after a skin permeation test was performed on the three-dimensional cultured epidermal model using aqueous dispersions of 0.001% by mass, 0.0025% by mass, and 0.005% by mass Pal-GH in Example 1. Figure 2 is a graph showing the amount of nicotinamide permeation detected in the reservoir solution after a skin permeation test was performed on the three-dimensional cultured epidermal model using aqueous dispersions of 0.001% by mass, 0.0025% by mass, and 0.005% by mass Pal-GH in Example 1. Figure 3 is a graph showing the amount of nicotinamide permeation extracted from a three-dimensional cultured epidermal model after a skin permeation test was performed on the three-dimensional cultured epidermal model using the aqueous dispersion of 0.025% by mass Pal-GH in Example 3 and the aqueous dispersions of 0.005% by mass or 0.025% by mass Pal-GH in Examples 4 and 5. Figure 4 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was performed on a three-dimensional cultured epidermal model using the 0.025% by mass Pal-GH aqueous dispersion of Example 3, and the 0.005% by mass or 0.025% by mass Pal-GH aqueous dispersions of Examples 4 and 5. Figure 5 is a graph showing the amount of nicotinamide permeation extracted from a three-dimensional cultured epidermal model after a skin permeation test was performed on a three-dimensional cultured epidermal model using the 0.025% by mass Pal-GH aqueous dispersion of Examples 6 to 10, and the 0.05% by mass Pal-GH aqueous dispersion of Example 11. Figure 6 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was performed on a three-dimensional cultured epidermal model using the 0.025% by mass Pal-GH aqueous dispersion of Examples 6 to 10, and the 0.05% by mass Pal-GH aqueous dispersion of Example 11. Fig. 7 is a graph showing the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model after a skin permeation test was performed on the three-dimensional cultured epidermal model using an aqueous dispersion of 0.05% by mass Pal-GH from each of Examples 11 to 14. Fig. 8 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was performed on the three-dimensional cultured epidermal model using an aqueous dispersion of 0.05% by mass Pal-GH from each of Examples 11 to 14.Figure 9 is a photograph obtained by taking a Schottky field emission scanning electron microscope of the surface of a fiber membrane formed on the surface of an artificial leather supplier sprayed with an aqueous dispersion of 0.05% by mass of Pal-GH for each of Examples 11 to 14. Figure 10 is a photograph of PM2.5 particles adhering to the surface of an artificial leather supplier sprayed with purified water and then dried, and PM2.5 particles adhering to a fiber membrane formed on the surface of an artificial leather supplier sprayed with an aqueous dispersion of 0.05% by mass of Pal-GH for each of Examples 11 to 14 and then dried. Figure 11 is a graph showing the amount of water adsorption of hair treated with an aqueous dispersion of 0.025% by mass of Pal-GH for each of Examples 3 and 5, compared to damaged hair not treated with a lipid peptide solution. Figure 12 is a graph showing the amount of water adsorption of hair treated with a 1% by mass SDS solution, the 0.005% by mass Pal-GH and 1% by mass SDS solution of Example 10, and the 0.025% by mass Pal-GH and 1% by mass SDS solution of Example 10, compared to damaged hair not treated with a lipid peptide solution. Figure 13 is a graph showing the results of measuring the amount of lipid peptide that penetrated and adhered to damaged hair treated with 0.001% by mass, 0.0025% by mass, and 0.005% by mass Pal-GH aqueous dispersions of Examples 1 and 2, respectively. Figure 14 is a graph showing the results of measuring the amount of lipid peptide that penetrated and adhered to damaged hair treated with 0.0025% by mass, 0.005% by mass, and 0.025% by mass Pal-GH aqueous dispersions of Examples 3 to 5, respectively. Figure 15 is a graph showing the results of measuring the amount of lipid peptides that penetrated into and adhered to damaged hair treated with 0.0025% by mass, 0.005% by mass, and 0.025% by mass Pal-GH aqueous dispersions from Examples 9 and 10, respectively. Figure 16 is a graph showing the results of measuring the amount of lipid peptides that penetrated into and adhered to damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 1 or Preparation Example 2, respectively. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid alone, 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 16), and 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 17).Figure 17 is a graph showing the amount of succinic acid extracted from damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 1 or Preparation Example 2. The concentrations of succinic acid and Pal-GH were 1% by mass succinic acid alone, 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 16), and 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 17). Figure 18 is a graph showing the results of measuring the amount of lipid peptides that penetrated and adhered to damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 3, Preparation Example 4, or Preparation Example 5. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid only, 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 18), 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 19), and 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 20). Fig. 19 is a graph showing the amount of succinic acid extracted from damaged hair treated with a commercially available shampoo and conditioner containing only succinic acid, or succinic acid and Preparation Example 3, Preparation Example 4, or Preparation Example 5. The concentrations of succinic acid and Pal-GH were 1% by mass succinic acid only, 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 18), 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 19), and 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 20). Fig. 20 is a graph showing the results of measuring the breaking strength of the composition (5% by mass Pal-GH) of Preparation Example 5 shown in Example 5 and the compositions (5% by mass Pal-GH) of Comparative Preparation Examples 6 and 7 shown in Comparative Examples 6 and 7. Fig. 21 is a photograph of an aqueous dispersion of a Pal-GH composition [from left: Example 5 (Preparation Example 5 diluted with water to a Pal-GH concentration of 0.25%), Comparative Example 4 (Comparative Preparation Example 4 diluted with water to a Pal-GH concentration of 0.25%), and Comparative Example 5 (Comparative Preparation Example 5 diluted with water to a Pal-GH concentration of 0.25%)]. Fig. 22 is a graph showing the results of measurement of water contact angles according to the examples. Fig. 23 is a graph showing the results of measurement by the SAXS method for the Pal-GH compositions of Example 5 and Comparative Examples 4 and 5.FIG. 24 is a graph showing the results of measurement by the SAXS method for the Pal-GH aqueous dispersions of Example 5 and Comparative Examples 4 and 5.

[0010] The present invention relates to a composition containing a specific lipid peptide-type compound, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water. The composition of the present invention can form a film on the surface of skin, hair, nails, clothing, or paper, thereby preventing the adhesion of contaminants such as dust to the skin, hair, clothing, or paper surface, thereby preventing contamination by these substances (anti-pollution effect), as well as promoting skin penetration, repairing hair, and preventing damage to hair caused by ultraviolet rays. Target substances to be prevented from adhering to and contaminating the skin, hair, clothing, or paper surface include dust, pollen, air pollutants such as exhaust gases and factory smoke, particulate matter contained in cigarette smoke (PM10, suspended particulate matter (SPM), PM2.5 (fine particulate matter), etc.), gaseous substances (such as SOx and CO), odorous substances, and even house dust, allergens such as fungi, mites (including dead mites), and viruses such as influenza viruses. Each component will be described below.

[0011] [Composition] [Lipid peptide type compound] The lipid peptide type compound used in the composition of the present invention has a lipid portion consisting of an aliphatic group having 10 to 24 carbon atoms (the total number of carbon atoms in the lipid portion is 10 to 24), to which a peptide portion formed by repeating at least two or more identical or different amino acids is bound. For example, compounds (lipid peptides) represented by the following formulas (1) to (3) or pharmaceutically usable salts thereof (low molecular weight compounds having a lipid portion as a hydrophobic portion and a peptide portion as a hydrophilic portion) can be used.

[0012]

[0013] In the above formula (1), R １ represents an aliphatic group having 9 to 23 carbon atoms, and preferably, R １ R is preferably a linear aliphatic group having 11 to 23 carbon atoms and which may have 0 to 2 unsaturated bonds.１ and an adjacent carbonyl group. Specific examples of the lipid moiety (acyl group) composed of a lauroyl group, a dodecylcarbonyl group, a myristoyl group, a tetradecylcarbonyl group, a palmitoyl group, a margalloyl group, an oleoyl group, an elideyl group, a linoleoyl group, a stearoyl group, a vaccenoyl group, an octadecylcarbonyl group, an arachidoyl group, an eicosylcarbonyl group, a behenoyl group, an elcanoyl group, a docosylcarbonyl group, a lignoceyl group, a nervonoyl group, and the like can be mentioned. Particularly preferred are a lauroyl group, a myristoyl group, a palmitoyl group, a margalloyl group, a stearoyl group, an oleoyl group, an elideyl group, and a behenoyl group.

[0014] In the above formula (1), R contained in the peptide portion ２ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. The alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms means an alkyl group having 1 to 4 carbon atoms in the main chain and which may have a branched chain having 1 or 2 carbon atoms, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, an i-butyl group, a sec-butyl group, and a tert-butyl group. ２ is preferably a hydrogen atom or an alkyl group of 1 to 3 carbon atoms which may have a branched chain of 1 carbon atom, and more preferably a hydrogen atom. The alkyl group of 1 to 3 carbon atoms which may have a branched chain of 1 carbon atom means an alkyl group having 1 to 3 carbon atoms in the main chain and which may have a branched chain of 1 carbon atom, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, and a sec-butyl group, and preferably a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group.

[0015] In the above formula (1), R ３ Ha-(CH ２ )n-X group. ２ In the n-X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２group, a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. ３ Representing -(CH ２ In the n-X group, X is preferably an amino group, a guanidino group, a carbamoyl group (-CONH ２ group), a pyrrole group, an imidazole group, a pyrazole group or an indole group, and more preferably an imidazole group. ２ In the —(CH )n-X group, n is preferably 1 or 2, and more preferably 1. ２ ) The n-X group preferably represents an aminomethyl group, a 2-aminoethyl group, a 3-aminopropyl group, a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-carbamoylbutyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, more preferably a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-guanidinobutyl group, a 4-imidazolemethyl group, or a 3-indolemethyl group, and even more preferably a 4-imidazolemethyl group.

[0016] Particularly suitable lipid peptides in the compound represented by formula (1) as lipid peptide compounds are compounds formed from the following lipid portion and peptide portion (amino acid assembly portion): alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp), and valine (Val). : Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl-Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala-Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl palmitoyl-Gly-His, palmitoyl-Gly-Gln, palmitoyl-Gly-Asn, palmitoyl-Gly-Trp, palmitoyl-Gly-Lys, palmitoyl-Ala-His, palmitoyl-Ala-Gln, palmitoyl-Ala-Asn, palmitoyl-Ala-Trp, palmitoyl-Ala-Lys; Stearoyl-Gly-His, stearoyl-Gly-Gln, stearoyl-Gly-Asn, stearoyl-Gly-Trp, stearoyl-Gly-Lys, stearoyl-Ala-His, stearoyl-Ala-Gln, stearoyl-Ala-Asn, stearoyl-Ala-Trp, stearoyl-Ala-Lys.

[0017] Most preferred are lauroyl-Gly-His, lauroyl-Ala-His, myristoyl-Gly-His, myristoyl-Ala-His, palmitoyl-Gly-His, palmitoyl-Ala-His, stearoyl-Gly-His, and stearoyl-Ala-His.

[0018]

[0019] In the above formula (2), R ４ represents an aliphatic group having 9 to 23 carbon atoms, and preferred examples thereof include the above-mentioned R １ In the above formula (2), R ５ ~R ７ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) represents an n-X group, preferably R ５ ~R ７ At least one of the following is -(CH ２ ) represents an n-X group, where n is a number from 1 to 4, and X represents an amino group, a guanidino group, or —CONH ２ group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. ５ ~R ７ Preferred examples of R ２ and R ３ The same groups as defined above are included.

[0020] In the compound represented by the above formula (2), preferred lipid peptides are compounds formed from the following lipid portion and peptide portion (amino acid assembly portion): for example, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, myristoyl-Gly-Gly-Gln, myristoyl-Gly-Gly-Asn, myristoyl-Gly-Gly-Trp, myristoyl-Gly-Gly-Lys, myristoyl-Gly-Ala-His, myristoyl-Gly-Ala-Gln, myristoyl-Gly-Ala-A sn, myristoyl-Gly-Ala-Trp, myristoyl-Gly-Ala-Lys, myristoyl-Ala-Gly-His, myristoyl-Ala-Gly-Gln, myristoyl-Ala-Gly-Asn, myristoyl-Ala-Gly-Trp, myristoyl-Ala-Gly-Lys, myristoyl-Gly-His-Gly, myristoyl-His-Gly-Gl y, palmitoyl-Gly-Gly-His, palmitoyl-Gly-Gly-Gln, palmitoyl-Gly-Gly-Asn, palmitoyl-Gly-Gly-Trp, palmitoyl-Gly-Gly-Lys, palmitoyl-Gly-Ala-His, palmitoyl-Gly-Ala-Gln, palmitoyl-Gly-Ala-Asn, palmitoyl-Gly-Ala-Trp , palmitoyl-Gly-Ala-Lys, palmitoyl-Ala-Gly-His, palmitoyl-Ala-Gly-Gln, palmitoyl-Ala-Gly-Asn, palmitoyl-Ala-Gly-Trp, palmitoyl-Ala-Gly-Lys, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl-Gly-Gly-His.

[0021] Of these, most preferred are lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, and stearoyl-Gly-Gly-His.

[0022]

[0023] In the above formula (3), R ８ represents an aliphatic group having 9 to 23 carbon atoms, and preferred examples thereof include the above-mentioned R １ In the above formula (3), R ９ ~R １２ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) represents an n-X group, preferably R ９ ~R １２ At least one of the following is -(CH ２ ) represents an n-X group, where n is a number from 1 to 4, and X represents an amino group, a guanidino group, or —CONH ２ group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. ９ ~R １２ Preferred examples of R ２ and R ３ The same groups as defined above are included.

[0024] Therefore, in the compound represented by the above formula (3), preferred lipid peptide compounds, particularly preferred lipid peptides, include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-His-Gly, palmitoyl-Gly-His-Gly-Gly, palmitoyl-His-Gly-Gly, palmitoyl-His-Gly-Gly, stearoyl-Gly-Gly-Gly-His, and the like.

[0025] In the present invention, the amount of the lipid peptide compound is adjusted depending on the intended use of the composition, as described below. The lipid peptide compound used in the present invention is at least one of the compounds (lipopeptides) represented by the above formulas (1) to (3) or pharmaceutically acceptable salts thereof, and these compounds can be used alone or in combination of two or more.

[0026] [Sucrose Esters] In the present invention, preferred sucrose esters include sucrose caprate, sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose oleate, sucrose arachidate, sucrose behenate, sucrose polystearate, sucrose stearate, etc., and particularly preferred sucrose esters are sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose polystearate, and sucrose stearate, more preferably sucrose polystearate and sucrose stearate, and most preferably sucrose stearate.

[0027] In the present invention, the amount of sucrose ester to be blended is, for example, 0.001 to 20% by mass, preferably 0.005 to 10.0% by mass, more preferably 0.01 to 10.0% by mass, even more preferably 0.05 to 5.0% by mass, and particularly preferably 0.1 to 5.0% by mass, relative to the total mass of the composition. The sucrose ester used in the present invention is at least one of the above sucrose esters, and these sucrose esters can be used alone or in combination of two or more.

[0028] [1,2-Alkanediol] The 1,2-alkanediol used in the present invention has the function of promoting the solubility of the lipid peptide-type compound. Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol. 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol are preferred. 1,2-pentanediol or 1,2-hexanediol are more preferred. 1,2-pentanediol is most preferred. The 1,2-alkanediol used in the present invention is at least one member of the 1,2-alkanediol group described above, and these 1,2-alkanediols can be used alone or in combination of two or more members. In particular, when 1,2-pentanediol or 1,2-hexanediol is used, when the composition of the present invention containing the diol, lipid peptide, and sucrose ester is in a solid state, the diol functions to adjust the hardness at that time and also functions to adjust the water penetration of the lipid peptide film formed when added to a cosmetic product.

[0029] In the present invention, the amount of 1,2-alkanediol blended can be, for example, 0.001 to 60% by mass, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass, relative to the total mass of the composition. The 1,2-alkanediol used in the present invention is at least one of the above 1,2-alkanediols, and these 1,2-alkanediols can be used alone or in combination of two or more.

[0030] [Fatty Acid] The composition of the present invention contains a fatty acid. The fatty acid has the function of stabilizing the structure (fiber structure, membrane structure, etc.) of the lipid peptide-type compound. In the present invention, the fatty acid is preferably at least one selected from the group consisting of saturated and unsaturated fatty acids having 10 to 20 carbon atoms and salts of these fatty acids, and examples of fatty acids include capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, and stearic acid. More preferred are capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid, with stearic acid being the most preferred.

[0031] In the present invention, the amount of the fatty acid to be added may be, for example, 0.0001 to 10.0% by mass, preferably 0.005 to 5.0% by mass, and more preferably 0.01 to 1.0% by mass, relative to the total mass of the composition. The fatty acid used in the present invention is at least one of the above fatty acids, and these fatty acids may be used alone or in combination of two or more.

[0032] [Other Components] The composition of the present invention contains water. The composition of the present invention may contain, in addition to the lipid peptide compound, 1,2-alkanediol, sucrose ester, fatty acid, and water, an alcohol, a polyhydric alcohol, or a mixture thereof.

[0033] Examples of the water include purified water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

[0034] The alcohol is a monohydric alcohol, and examples thereof include alcohols having 1 to 6 carbon atoms that dissolve in water in any proportion, specifically methanol, ethanol, 2-propanol, and i-butanol, as well as higher alcohols, specifically oleyl alcohol and phenoxy alcohol.

[0035] The polyhydric alcohol is a dihydric or higher alcohol (excluding the above-mentioned 1,2-alkanediols), and examples thereof include propylene glycol, 1,3-butanediol, 2-ethyl-1,3-hexanediol, glycerin, isopentyldiol, ethylhexanediol, erythrulose, ozonated glycerin, caprylyl glycol, glycol, (C15-18) glycol, (C20-30) glycol, diethylene glycol, diglycerin, dithiaoctanediol, DPG, thioglycerin, 1,10-decanediol, decylene glycol, triethylene glycol, methylhydroxymethylcyclohexanol, phytantriol, phenoxypropanediol, 1,2-butanediol, 2,3-butanediol, butylethylpropanediol, 1,2-hexanediol, hexylene glycol, pentylene glycol, methylpropanediol, menthanediol, lauryl glycol, and polypropylene glycol.

[0036] In the present invention, when a polyhydric alcohol is contained, the content thereof can be, for example, 0.001% by mass to 60% by mass, preferably 0.001% by mass to 30% by mass, and more preferably 0.01% by mass to 10% by mass. In the present invention, when a polyhydric alcohol is contained, the polyhydric alcohol can be used alone or in combination of two or more kinds.

[0037] [Other Additives] The composition of the present invention may contain additives that can generally be used as cosmetic additives, quasi-drug additives, and pharmaceutical additives (additive components such as physiologically active substances and functional substances to be incorporated into topical skin preparations such as cosmetics, quasi-drugs, or pharmaceuticals), as needed. Examples of additive components such as physiologically active substances and functional substances to be incorporated into topical skin preparations such as cosmetics, quasi-drugs, or pharmaceuticals include pigments, oily bases, moisturizers, texture improvers, surfactants, polymers / thickeners / gelling agents, solvents, antioxidants, reducing agents, oxidizing agents, preservatives, antibacterial agents, disinfectants, chelating agents, pH adjusters / acids / alkalis, powders, inorganic salts, UV absorbers, whitening agents, vitamins and their derivatives, and hair growth agents / blood circulation promoters. Examples of such additives include irritants, hair graying prevention agents, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation alleviators, analgesics, cell activators, plant / animal / microbial extracts, antipruritics, exfoliating / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, pigments / coloring agents / dyes, anti-inflammatory / anti-inflammatory agents, antiasthmatic agents, anti-chronic obstructive pulmonary disease agents, antiallergic agents, immunomodulators, anti-infective agents, antifungal agents, etc. The content of these other additives may vary depending on the type, but may be, for example, about 0.001% to 20% by mass, or 0.01% to 10% by mass, relative to the total mass of the composition.

[0038] inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride and fish scale leaf; extender pigments such as talc, sericite, mica, kaolin, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate and aluminum hydroxide; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; organic pigments such as zirconium, barium or aluminum lake;

[0039] Examples of oily bases include higher (polyhydric) alcohols such as oleyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols such as benzyl alcohol and derivatives thereof; stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, and isohe xadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, etc.; hydrocarbons such as liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, and microcrystalline Waxes such as petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated yam Vegetable oils and fats such as oat oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, grapeseed oil, apricot oil (almond oil), and camellia oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil; lanolins such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, acetated lanolin alcohol, and cetyl lanolyl acetate esters;Sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid, etc.; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl acyl sarcosine alkyl esters such as di(phytosteryl / octyldodecyl)-L-glutamate and N-lauroyl sarcosine isopropyl, sterol esters such as cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, hexyldecyl dimethyloctanoate, octyl erucate Monoalcohol carboxylic acid esters such as tildodecyl, hydrogenated castor oil isostearate, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, and hydrogenated castor oil monoisostearate;Glyceryl trioctanoate (glyceryl tri-2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosandioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, diisostearate Neopentyl glycol octanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, pentaerythrityl hydrogenated rosin, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearate / stearic acid / rosin acid, diglyceride diisostearate Polyhydric alcohol fatty acid esters such as lyceryl, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca(erucic acid / isostearate / ricinoleic acid)polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; diisopropyl dimer dilinoleate, dimer Derivatives of dimer acid or dimer diol such as diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane (also simply cyclopentasiloxane)), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethylaminopropylmethicone / dimethicone). Preferred examples of the silicone oil include silicones such as methyl methicone copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, and polysiloxane-oxyalkylene copolymer; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

[0040] Examples of moisturizing agents and texture improvers include polyols and polymers thereof such as glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 and tetradecanedioic acid polyglyceryl-10; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and maltose), Modified cyclodextrins (e.g., cyclodextrins modified by silylating or hydroxyalkylating), β-glucan, chitin, chitosan, heparin and its derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymers or copolymers, and other sugars and derivatives thereof; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide, or naturally derived Polysaccharides; organic acids such as citric acid, tartaric acid, and lactic acid and their salts; urea and its derivatives; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, glucocyamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine and their salts;Collagen, fish collagen, atelocollagen, gelatin, elastin, collagen hydrolysis peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolysis peptides, keratin hydrolysis peptides, hydrolyzed keratin, conchiolin hydrolysis peptides, hydrolyzed conchiolin, silk proteolysis peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolysis peptides, wheat proteolysis peptides, hydrolyzed wheat protein, casein hydrolysis peptides, acylated peptides and their derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; Preferred examples of such ingredients include silylated peptides; lactic acid bacteria culture medium, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; animal and plant extracts such as placenta extract, alastin, collagen, aloe extract, witch hazel water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, Rosa robur extract, yarrow extract, eucalyptus extract, and melilot extract; and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and glycoceramide-containing extracts.

[0041] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants, etc. Preferred examples of the surfactant include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methylamino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl methyl alanine glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, triethanolamine cocoyl alanine glutamate, sodium methyl ... ethanolamine and the like; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactate salts; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecylbenzenesulfonate;alkyl naphthalene sulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethphosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate salts; fatty acid amide ether phosphate salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants such as laureths (polyoxyethylene lauryl ethers), ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), octyldodeceths (polyoxyethylene octyl dodecyl ethers); polyoxyethylene alkylphenyl ethers; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, and polyoxyethylene-polyoxypropylene alkyl ethers such as polyoxyethylene-polyoxypropylene glycerin ether;Polyoxyethylene polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, α,α'-oleic acid pyroglutamic acid glycerin, glycerin monostearate malic acid, etc.; polyglyceryl stearate 2, 3, 4, 5, 6, 8, 10, Polyglyceryl-6 distearate, 10, Polyglyceryl-2 tristearate, Polyglyceryl-10 decastearate, Polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, Polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decastearate, Polyglyceryl-2 oleate, 3, 4, 5, 6, 8 , 10, polyglycerin fatty acid esters such as polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monooleate Sorbitan fatty acid esters such as urate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; partial esters of sugar derivatives such as methyl glucoside fatty acid esters and trehalose undecylenate; alkyl glucosides such as lauryl glucoside, (caprylyl / capryl) glucoside, and caprylyl glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin;Polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl Glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA);Alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyltrimethylammonium chlorides such as limonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl ether amines and salts or quaternary salts thereof such as stearoxypropyldimethylamine; ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium, Fatty acid amide type quaternary ammonium salts such as lanolin ethyl sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl ether amine ammonium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; aminopropyl dimethicone and amodimethicone silicone-based cationic surfactants such as amino-modified silicones, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate;alkyl sulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate esters; phosphate-type betaines such as alkyldimethylaminoethanol phosphate esters; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; and preferred polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants.

[0042] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its sodium salt and other salts, alginic acid and its sodium salt and other salts, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, and chitin. cellulose, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose and its salts such as sodium salt, methylhydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder; soluble starch, carboxymethyl starch, Starch-based polymers such as methylhydroxypropyl starch, methyl starch, and the like, starch derivatives such as hydroxypropyltrimonium starch chloride, corn starch aluminum octenylsuccinate, and the like; alginic acid derivatives such as sodium alginate, propylene glycol alginate, and the like; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer;Acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymers such as Polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymers, acrylic acid-cationized methacrylic acid amide copolymers, acrylic acid-methyl acrylate-methacrylamide propyl chloride such as Polyquaternium-47 trimethylammonium copolymer, methacrylic acid chloride choline ester polymer; cationic polysaccharides such as cationic oligosaccharides, cationized dextran, and guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers, etc.; polymer emulsions such as acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate;Preferred examples include anhydrous silicic acid, fumed silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, and fructooligosaccharide fatty acid ester. Among these examples, cellulose and its derivatives, alginic acid and its salts, polyvinyl alcohol, hyaluronic acid and its salts, and collagen are preferred.

[0043] Preferred examples of the solvent include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; glycol ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; and toluene.

[0044] Preferred examples of the antioxidant include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride.

[0045] Preferred reducing agents include thioglycolic acid, cysteine, cysteamine, and the like.

[0046] Preferred examples of the oxidizing agent include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

[0047] Preferred examples of the preservative, antibacterial agent, and disinfectant include hydroxybenzoic acids such as methylparaben, ethylparaben, propylparaben, and butylparaben, and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions.

[0048] Preferred examples of the chelating agent include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA 2Na, EDTA 3Na, and EDTA 4Na; hydroxyethylethylenediaminetriacetates such as EDTA 3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as sodium salts; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0049] Preferred examples of the pH adjuster, acid, or alkali include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0050] Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate such as tricalcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, iron blue, carbon black, titanium oxide, fine and ultrafine titanium oxide particles, zinc oxide, fine and ultrafine zinc oxide particles, alumina, silica, fumed silica (ultrafine silicic anhydride particles), mica titanium dioxide, and the like. Preferred examples include inorganic powders of various sizes and shapes, such as tan, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine phlogopite, fine particle composite powders, gold, silver, platinum, and aluminum, and inorganic powders obtained by treating these with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, and Teflon (registered trademark) powder, as well as surface-treated powders and organic-inorganic composite powders.

[0051] Preferred examples of inorganic salts include sodium chloride-containing salts such as table salt, ordinary salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0052] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid methyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; octyl cinnamate, ethyl ... cinnamic acid-based ultraviolet absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, ferulic acid and its derivatives;Benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl Preferred examples include hydantoin derivatives such as 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives;

[0053] Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides and fatty acid esters thereof such as ascorbic acid-2-glucoside, ascorbic acid sulfate, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; Preferred examples include diacid, ellagic acid, tranexamic acid and derivatives thereof, ferulic acid and derivatives thereof, placenta extract, glutathione, oryzanol, butylresorcinol, plant extracts such as oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract and saxifrage extract, 4-n-butylresorcinol (Rucinol), linoleic acid S (Linolec S), 4-methoxysalicylic acid potassium salt, adenosine phosphate disodium, 5,5'-dipropyl-biphenyl-2,2'-diol (magnolignan), dexpanthenol W, tranexamic acid cetyl hydrochloride, and rhododenol.

[0054] Vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and cholines; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; and vitamin B such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred examples include ascorbic acid derivatives such as scorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides and fatty acid esters thereof such as ascorbic acid-2-glucoside, and tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate; tocotrienol; and various other vitamin derivatives.

[0055] Examples of hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharides tincture; capsaicin, nonylic acid vanillylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, vitamin E, and derivatives such as tocopherol nicotinate and tocopherol acetate, nicotinic acid, and nicotinamide (niacin). Preferred examples of the inhibitor include nicotinic acid derivatives such as benzophenone amide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotinic alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and glycosides thereof, minoxidil, the ALK5 inhibitory compounds described in the specification of WO 2005 / 085241, and the WNT-5 inhibitory compounds described in the specification of WO 2003 / 086334.

[0056] Preferred examples of the anti-graying agent include watercress, soapberry, saxifrage, and thyme.

[0057] Preferred examples of hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0058] Other medicinal agents such as anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation soothing agents, analgesics, and cell activators include retinols, retinoic acids, and tocopheryl retinoate; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid, and derivatives thereof such as glycosides and esters thereof, hydroxycapric acid, long-chain α-hydroxy fatty acids, and long-chain α-hydroxy fatty acid cholesteryl, and other α- or β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine, and derivatives thereof; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, α-lipoic acid, platinum Preferred examples include antioxidants / active oxygen scavengers such as nanocolloids and fullerenes; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, and apple polyphenol; rutin and its derivatives; hesperidin and its derivatives; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances and derivatives thereof such as menthol and cedrol; capsaicin, vanillin, and derivatives thereof; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

[0059] Plant, animal and microbial extracts include iris extract, angelica extract, douglas fir extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althaea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica tree extract, echinacea leaf extract, emmeiso extract, scutellaria root extract, phellodendron bark extract, coptis extract, barley extract, ginseng extract, St. John's wort extract, and odo extract. Lycosoma extract, Ononis extract, Watercress extract, Orange extract, Dried seawater, Seaweed extract, Oyster leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria root extract, Chamomilla extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karkade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Angelica root extract, Wood ear extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora root extract, Gardenia extract, Sasa veitchii extract Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, Chinese radish extract, Bupleurum Root extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, Chinese radish extract , Zanthoxylum extract, Shiitake mushroom extract, Rehmannia root extract, Lithospermum root extract, Perilla extract, Tilia extract, Meadowsweet extract, Jatoba extract, Peony extract, Angelica root extract, Calamus root extract, Birch extract, White wood ear extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Ivy extract, Hawthorn extract, Elderberry extract, Yarrow extract, Peppermint extract, Sage extract, Mallow extract, Cnidium extract, Swertia japonica extract, Sophora japonica extract, Rhubarb extract,Soybean extract, Chinese laurel extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, jasmine extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, poria cocos extract, butcher's broom extract, grape extract, grape seed extract Preferred examples of extracts include kiss, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0060] Antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance P inhibitors, and the like.

[0061] Examples of keratin exfoliating / dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine.

[0062] Antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, and the like.

[0063] Cooling agents include menthol and methyl salicylate.

[0064] Astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, and the like.

[0065] Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease.

[0066] Preferred examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

[0067] Fragrances include acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, ISOE Super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styrallyl acetate, cedryl acetate, terpinel acetate, and p-t-butylcyclohexyl acetate. , vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripluran, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzene Preferred examples of the fragrance include synthetic fragrances, natural fragrances, and various blended fragrances such as maltodextrin, borneol, myrrh resinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils.

[0068] Pigments, colorants, and dyes include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, and Red No. 1. No. 02, Red 104-1, Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225 No., Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red Color No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Legal dyes such as Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, and Yellow No. 5; Acid Other acid dyes such as Arianor Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes;Preferred examples include natural pigments and dyes such as anthraquinones such as astaxanthin and alizarin, naphthoquinones such as anthocyanidin, β-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, cochineal, and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

[0069] Preferred examples of the anti-inflammatory agent include glycyrrhizinic acid and derivatives thereof, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

[0070] Preferred examples of antiasthmatic agents, anti-chronic obstructive pulmonary disease agents, antiallergic agents, and immunomodulators include aminophylline, theophyllines, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, β2 agonists (formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorfan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, mequitazine, tacrolimus, cyclosporine, sirolimus, methotrexate, cytokine regulators, interferon, omalizumab, and protein / antibody preparations.

[0071] Preferred examples of the anti-infective agent and anti-fungal agent include oseltamivir, zanamivir, and itraconazole. In addition to these, known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as ingredients listed in the Standards for Cosmetic Raw Materials, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additive Standards, Food Additives Official Standards, etc., and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) classified under the International Patent Classification IPC A61K7 and A61K8, can be contained in known combinations, blending ratios, and blending amounts.

[0072] The composition of the present invention may be in any formulation as long as it can form a film (layer) on the skin or hair surface. Examples include, but are not limited to, emulsions such as oil-in-water (O / W), water-in-oil (W / O), W / O / W, and O / W / O, as well as oils, solids, liquids, pastes, sticks, volatile oils, powders, jellies, gels, pastes, emulsified polymers, sheets, mist forms, and sprays. The composition may also be in any product form, such as a dispersion, emulsion, cream, pack, spray, or gel. The composition may contain various ingredients known to those skilled in the art to achieve the desired formulation or product form. When the content of the lipid peptide compound in the composition is, for example, 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition, the composition can be used as a cosmetic, particularly a hair cosmetic.

[0073] [Content of Lipid Peptide Compound in Composition] When the content of the lipid peptide compound relative to the total mass of the composition of the present invention is 1.0 mass% or more and 20.0 mass% or less, preferably 1.0 mass% or more and 10.0 mass% or less, and more preferably 4.0 mass% or more and 6.0 mass% or less, the composition of the present invention becomes a white solid at room temperature and can be stored at room temperature. Furthermore, the breaking strength (breaking stress) is, for example, 1.0 to 5.0 × 10５ Pa, preferably 2.0 to 4.0 × 10 ５ Pa, more preferably 2.0 to 3.0 × 10 ５ In the case of 0.05 Pa, the composition is resistant to crumbling and is excellent in transportation, storage, etc. The breaking strength can be measured, for example, using a YAMADEN RHEONER II CREEEP METER RE2-33005B (Yamaden Co., Ltd.) at a measurement speed of 1 mm / sec, a measurement strain rate of 80%, a storage pitch of 0.10 sec, and a jig: 30349-3. When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the sucrose ester is 0.5% by mass or more and 10.0% by mass or less, preferably 0.5% by mass or more and 5.0% by mass or less, and more preferably 2.0% by mass or more and 3.0% by mass or less, relative to the total mass of the composition of the present invention. When the content of the lipid peptide-type compound in the composition of the present invention is within the above range, the content of the 1,2-alkanediol is 1.4% by mass or more and 28.0% by mass or less, preferably 1.4% by mass or more and 14.0% by mass or less, and more preferably 5.6% by mass or more and 8.4% by mass or less, relative to the total mass of the composition of the present invention. When the content of the lipid peptide-type compound in the composition of the present invention is within the above range, the content of the fatty acid is 0.1% by mass or more and 2.0% by mass or less, preferably 0.1% by mass or more and 1.0% by mass or less, and more preferably 0.4% by mass or more and 0.6% by mass or less, relative to the total mass of the composition of the present invention. When the content of the lipid peptide-type compound in the composition of the present invention is within the above range, the content of water is 40.0% by mass or more and 97.0% by mass or less, preferably 70.0% by mass or more and 97.0% by mass or less, and more preferably 82.0% by mass or more and 88.0% by mass or less.

[0074] Furthermore, when the composition of the present invention is further diluted with water, the content of the lipid peptide type compound relative to the total mass of the composition is 0.0001% by mass or more and 0.5% by mass or less, preferably 0.0001% by mass or more and 0.2% by mass or less, more preferably 0.001% by mass or more and 0.05% by mass or less, even more preferably 0.005% by mass or more and 0.05% by mass or less, or preferably 0.001% by mass or more and 0.5% by mass or less, more preferably 0.005% by mass or more and 0.25% by mass or less, even more preferably 0.01% by mass or more and 0.25% by mass or less, and the lipid peptide type compound is uniformly dispersed in the liquid without causing precipitation or sedimentation over time at low temperatures or room temperature, and the composition of the present invention becomes a transparent dispersion liquid with high dispersion stability. In the present invention, low temperature refers to a temperature lower than room temperature, and refers to a temperature of 0° C. or higher but lower than 15° C., or 4° C. or higher but lower than 15° C., and room temperature refers to 15° C. or higher but lower than 40° C., or 15° C. or higher but lower than 30° C. When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the sucrose ester is 0.00005% by mass or higher but lower than 0.25% by mass, preferably 0.00005% by mass or higher but lower than 0.1% by mass, more preferably 0.0005% by mass or higher but lower than 0.025% by mass, even more preferably 0.0025% by mass or higher but lower than 0.025% by mass, or preferably 0.0005% by mass or higher but lower than 0.25% by mass, more preferably 0.0025% by mass or higher but lower than 0.125% by mass, and even more preferably 0.005% by mass or higher but lower than 0.125% by mass. When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the 1,2-alkanediol is, relative to the total mass of the composition of the present invention, 0.00014% by mass or more and 0.7% by mass or less, preferably 0.00014% by mass or more and 0.28% by mass or less, more preferably 0.0014% by mass or more and 0.07% by mass or less, even more preferably 0.007% by mass or more and 0.07% by mass or less, or preferably 0.0014% by mass or more and 0.7% by mass or less, more preferably 0.007% by mass or more and 0.35% by mass or less, even more preferably 0.014% by mass or more and 0.35% by mass or less.When the content of the lipid peptide type compound in the composition of the present invention is within the above range, the content of the fatty acid is 0.00001% by mass or more and 0.05% by mass or less, preferably 0.00001% by mass or more and 0.02% by mass or less, more preferably 0.0001% by mass or more and 0.005% by mass or less, even more preferably 0.0005% by mass or more and 0.005% by mass or less, or preferably 0.0001% by mass or more and 0.05% by mass or less, more preferably 0.0005% by mass or more and 0.025% by mass or less, even more preferably 0.001% by mass or more and 0.025% by mass or less. Because the dispersion stability of the composition of the present invention, which is a dispersion, is high, the composition of the present invention can be further diluted or directly mixed with other components in a subsequent process to produce a product, and the final product can be mixed evenly without any variation in quality.

[0075] [Method for Producing the Composition] The composition of the present invention can be produced, for example, by mixing at least one lipid peptide-type compound, a sucrose ester, a 1,2-alkanediol, water, a fatty acid, and other additives, stirring the mixture at room temperature or under heating, and then allowing the mixture to cool to about room temperature. The heating and stirring temperature is not particularly limited as long as the components can be mixed uniformly. For example, the stirring temperature can be 0°C to 90°C, 30°C to 90°C, e.g., 20°C, 30°C, 50°C, or 80°C, and the stirring time can be appropriately selected, for example, from 5 minutes to 3 hours.

[0076] [Method for Producing Lipid Peptide Dispersion Liquid] When the amount of lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition of the present invention, the composition of the present invention becomes a white solid at room temperature. Furthermore, when the white solid composition of the present invention is mixed with water and stirred at room temperature or under heat, the composition of the present invention becomes a transparent liquid with high dispersion stability at low or room temperature. In this case, the amount of lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition. This liquid composition of the present invention is also referred to as a lipid peptide dispersion liquid. It is a stable dispersion at low or room temperature, can be mixed uniformly without heating when used, and is easy to handle. The prepared lipid peptide dispersion liquid may be stored at room or low temperature. The amount of lipid peptide dispersion is preferably 0.0001% by mass or more and 0.2% by mass or less, more preferably 0.005% by mass or more and 0.5% by mass or less, and most preferably 0.01% by mass or more and 0.1% by mass or less relative to the total mass of the composition.

[0077] [Method for producing a cosmetic] The composition (white solid) stored at room temperature or low temperature can be heated and dissolved, mixed with various solvents and other additives, and stirred to produce a cosmetic that is solid at room temperature. The composition (dispersion) stored at room temperature or low temperature can be mixed with water, various solvents, and other additives, with or without heating, and stirred at room temperature or low temperature to produce a cosmetic. In this case, the amount of the lipid peptide compound is 0.0001% by mass or more and 5.0% by mass or less, preferably 0.0001% by mass or more and 0.5% by mass or less, and more preferably 0.0001% by mass or more and 0.25% by mass or less, relative to the total mass of the cosmetic. There are no particular restrictions on whether the cosmetic is solid or liquid. The amount of sucrose ester is, for example, 0.001 to 20% by mass, preferably 0.005 to 10.0% by mass, more preferably 0.01 to 10.0% by mass, even more preferably 0.05 to 5.0% by mass, and particularly preferably 0.1 to 5.0% by mass, relative to the total mass of the cosmetic. The amount of 1,2-alkanediol is, for example, 0.001 to 60% by mass, preferably 0.001 to 30% by mass, and even more preferably 0.01 to 10% by mass, relative to the total mass of the cosmetic. The amount of fatty acid is, for example, 0.0001 to 10.0% by mass, preferably 0.005 to 5.0% by mass, and even more preferably 0.01 to 1.0% by mass, relative to the total mass of the cosmetic.

[0078] In the present invention, the term "transparent" refers to a state in which no precipitates are visible in the composition when visually inspected. Alternatively, the transparency of a composition can be determined by evaluating the turbidity or transmittance using a turbidimeter or spectrophotometer, etc.

[0079] The present invention will be described in detail below using Examples 1 to 15 and Comparative Examples 1 to 4, but the present invention is not limited to these examples.

[0080] Synthesis Example 1: Synthesis of Lipid Peptide (N-Palmitoyl-Gly-His) The lipid peptide used as the gelling agent in this example was synthesized by the following method. 14.2 g (91.6 mmol) of histidine, 30.0 g (91.6 mmol) of N-palmitoyl-Gly-methyl, and 300 g of toluene were placed in a 500 mL four-neck flask, and 35.3 g (183.2 mmol) of a 28% methanol solution of sodium methoxide (a base) was added. The mixture was heated to 60°C in an oil bath and stirred for 1 hour. The oil bath was then removed, and the mixture was allowed to cool to 25°C. The solution was reprecipitated with 600 g of acetone and collected by filtration. The resulting solid was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and neutralized by adding 30.5 ml (183.2 mmol) of 6 N hydrochloric acid to precipitate a solid, which was then filtered. Next, the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60°C, 150 g of ethyl acetate was added, and the mixture was cooled from 60°C to 30°C. Thereafter, the precipitated solid was filtered. The obtained solid was further dissolved in a solvent of 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60°C, stirred for 1 hour, cooled, and filtered. The obtained solid was washed with 120 g of water, filtered, and then dried under reduced pressure to obtain 26.9 g (yield 65%) of white crystals of N-palmitoyl-Gly-His free form (hereinafter also simply referred to as Pal-GH).

[0081] Preparation Examples 1 to 15, Comparative Preparation Examples 1 to 4: Preparation of Pal-GH Compositions Using Various Sucrose Esters Pal-GH obtained in Synthesis Example 1 above, a 1,2-alkanediol, a sucrose ester or a surfactant, a fatty acid, and purified water were weighed out and placed in a 200 mL beaker (manufactured by HARIO Corporation) so as to give the compositions (mass: g) shown in Table 1, and the mixture was heated and stirred at 200 rpm for 30 minutes in a water bath set at a temperature of about 80°C to obtain Pal-GH compositions.

[0082]

[0083] Comparative Preparation Examples 5 to 7: Preparation of Pal-GH Compositions Pal-GH obtained in Synthesis Example 1 above, 1,2-alkanediol, sucrose ester or surfactant, fatty acid, and purified water were weighed out and placed in a 200 mL beaker (manufactured by HARIO Corporation) so as to have the composition (mass: g) shown in Table 2, and the mixture was heated and stirred at 200 rpm for 30 minutes in a water bath set at a temperature of about 80°C to obtain a Pal-GH composition.

[0084]

[0085] [Examples 1 to 15, Comparative Examples 1 to 4: Preparation of Aqueous Dispersions of Pal-GH Composition] The Pal-GH compositions obtained in Preparation Examples 1 to 15 and Comparative Preparation Examples 1 to 4 above and water were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred for 5 minutes at 200 rpm, and then allowed to stand at 25°C or cooled to 4°C, thereby diluting the mixture 200-fold or 1000-fold with water to prepare aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) shown in Tables 3 and 4. The prepared Pal-GH aqueous dispersions were visually evaluated with the following criteria: O: Pal-GH was uniformly dispersed in water (no precipitation or aggregation occurred), △: Pal-GH was uniformly dispersed in water but became non-uniform after a few days, and ×: Pal-GH was non-uniformly dispersed in water (precipitation or aggregation occurred). The results are shown in Tables 3 and 4.

[0086]

[0087]

[0088] [Example 5, Comparative Examples 4, 5, and 7: Preparation of Aqueous Dispersions of Pal-GH Composition] The Pal-GH compositions and water obtained in Preparation Example 5 and Comparative Preparation Examples 4, 5, and 7 above were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred for 5 minutes at 200 rpm and allowed to stand at room temperature to dilute the mixture 20-fold or 1000-fold with water to prepare aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) shown in Table 5. These were stored at 4°C or 25°C to compare their stability. The prepared Pal-GH aqueous dispersions were visually evaluated with the following criteria: O: Pal-GH was uniformly dispersed in water (no precipitation or aggregation occurred), △: Pal-GH was uniformly dispersed in water but became non-uniform after a few days, and ×: Pal-GH was non-uniformly dispersed in water (precipitation or aggregation occurred). The results are also shown in Table 5.

[0089]

[0090] Example 5, Comparative Examples 4 and 5: Preparation of Aqueous Dispersions of Pal-GH Composition The Pal-GH compositions obtained in Preparation Example 5, Comparative Preparation Example 4, and Comparative Preparation Example 5 and water were weighed, and the Pal-GH compositions were added to a 200 mL beaker (manufactured by HARIO Corporation) while stirring the water. The mixture was stirred at 200 rpm for 5 minutes and allowed to stand at room temperature. The mixture was diluted with water to a Pal-GH concentration of 0.25%, thereby preparing aqueous dispersions of the Pal-GH composition (also referred to as Pal-GH aqueous dispersions). These were stored at 25°C and compared for stability. The results are shown in FIG. 21 . As shown in FIG. 21 , Pal-GH was uniformly dispersed in water in Example 5 (diluted solution of Preparation Example 5), whereas precipitation or aggregation of Pal-GH was observed in Comparative Example 4 (diluted solution of Comparative Preparation Example 4) and Comparative Example 5 (diluted solution of Comparative Preparation Example 5).

[0091] Example 1: Skin penetration-enhancing effect of the active ingredient (nicotinamide: NA) of the lipid peptide composition A human three-dimensional cultured epidermal model (LabCyte EPI-MODEL24, φ6.4 mm, lot number #LCE12-200706-A, manufactured by Japan Tissue Engineering Co., Ltd.) was placed in a 24-well tissue culture plate (IWAKI, manufactured by Asahi Glass Co., Ltd.), and 1 mL of phosphate-buffered saline (pH 7.4) (PBS) was dispensed into each well, which served as a reservoir solution. On the donor side, Pal-GH aqueous dispersions of Example 1 were prepared with Pal-GH concentrations of 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, from Preparation Example 1. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by weight nicotinamide aqueous solution (NA water only) was also prepared. 200 μL of each preparation was added, and the tissue culture plate was covered with a lid and placed in an incubator at 37°C to conduct a skin permeability test. After 4 hours of permeation from the addition of each preparation, the reservoir solution and three-dimensional cultured epidermal model were collected. The collected three-dimensional cultured epidermal model was washed three times with 500 μL of PBS, cut into four equal pieces with a scalpel, and placed in a 1.5 mL microtube (manufactured by Eppendorf). Subsequently, 750 μL of a 1 / 1 v / v methanol / purified water extraction solution was added, and the mixture was treated in a vortex mixer (manufactured by Kenis Co., Ltd.) for 1 hour to extract nicotinamide from the three-dimensional cultured epidermal model, followed by filtration using a 0.45 μm pore size syringe filter (manufactured by Merck). The nicotinamide concentration in the obtained filtrate and reservoir solution is measured by high performance liquid chromatography (HPLC manufactured by Agilent), and the amount of nicotinamide permeated through the skin per unit area is calculated.The test is carried out three times for each specimen, and the average value is calculated, and the amount of permeated through the skin after 3 hours is calculated from this value.The HPLC measurement conditions are as follows:Detector: ultraviolet absorptiometer (measurement wavelength: 260 nm), column: stainless steel column with an inner diameter of 4.6 mm and a length of 25 cm packed with 3 μm octadecylsilylated silica gel for HPLC (ODS-4, GL Sciences Inc.), column temperature: 40°C, mobile phase: 0.1% aqueous acetic acid / 5 mM aqueous ICP-ALKS7:methanol=9:1 (v / v).

[0092] The results obtained are shown in Figures 1 and 2. Figure 1 shows the amount of nicotinamide permeated extracted from the three-dimensional cultured epidermal model, and Figure 2 shows the amount of nicotinamide permeated detected in the reservoir. The preparation solution of Example 1 showed a higher amount of nicotinamide permeated than when only a 1% by mass aqueous nicotinamide solution was added, at all concentrations.

[0093] Examples 3 to 5: Skin Permeation Enhancement Effect of the Active Ingredient (Nicotinamide) of the Lipid Peptide Composition Pal-GH aqueous dispersions of Examples 3 to 5 were prepared, each having a Pal-GH concentration of 0.025% by mass from Preparation Example 3, and 0.005% by mass and 0.025% by mass from Preparation Examples 4 and 5. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to a tissue culture plate, which was then covered with a lid and allowed to stand in an incubator at 37°C, whereupon a skin permeation test was performed.

[0094] The results are shown in Figures 3 and 4. Figure 3 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 4 shows the amount of nicotinamide permeation detected in the reservoir. The preparations of Examples 3 to 5 showed higher amounts of nicotinamide permeation at all concentrations than when only a 1% by mass aqueous nicotinamide solution was added.

[0095] [Examples 6 to 11: Skin Permeation Enhancement Effect of the Active Ingredient (Nicotinamide) of the Lipid Peptide Composition] Pal-GH aqueous dispersions of Examples 6 to 10, each with a Pal-GH concentration of 0.025% by mass, and Pal-GH aqueous dispersions of Examples 11 to 11, each with a Pal-GH concentration of 0.05% by mass, were prepared. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to a tissue culture plate, which was then covered with a lid and allowed to stand in an incubator at 37°C, whereupon a skin permeation test was performed.

[0096] The results are shown in Figures 5 and 6. Figure 5 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 6 shows the amount of nicotinamide permeation detected in the reservoir. The 0.025 mass% Pal-GH preparations of Examples 6 to 10 and the 0.05 mass% Pal-GH preparation of Example 11 showed a higher amount of nicotinamide permeation than when only a 1 mass% nicotinamide aqueous solution was added.

[0097] [Examples 11 to 14: Skin Permeation Enhancement Effect of the Active Ingredient (Nicotinamide) of the Lipid Peptide Composition] Pal-GH aqueous dispersions of Examples 11 to 14, each with a Pal-GH concentration of 0.05% by mass, were prepared from Preparation Examples 11 to 14, and nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to a tissue culture plate, which was then covered with a lid and allowed to stand in an incubator at 37°C, whereupon a skin permeation test was performed.

[0098] The results are shown in Figures 7 and 8. Figure 7 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 8 shows the amount of nicotinamide permeation detected in the reservoir. The 0.05% by mass Pal-GH preparations of Examples 11 to 14 showed a higher amount of nicotinamide permeation than when a 1% by mass aqueous nicotinamide solution was added.

[0099] Examples 11 to 14: Confirmation of film formation of lipid peptide composition Artificial leather Sapler (Idemitsu Technofine Co., Ltd.) was cut into 4 cm squares, and 1.0 mL of the 0.05% by mass Pal-GH aqueous dispersion prepared for each of Examples 11 to 14 above was applied, followed by drying for 1 hour in a thermostatic chamber at 32°C. The surface of each dried film produced was observed using a Schottky field emission scanning electron microscope JSM-7800F (JEOL Ltd.). Carbon tape was used to fix the sample, and measurements were taken at an acceleration voltage of 0.7 kV. The results are shown in Figure 9. It was confirmed that all of the dried films from Examples 11 to 14 formed fibrous films.

[0100] Examples 11-14: Inhibition of PM2.5 Particle Adhesion by Lipid Peptide Compositions Artificial leather, Sapler (Idemitsu Technofine Co., Ltd.), was cut into 4 cm squares and coated with 1.0 mL of each of the 0.05% by mass Pal-GH aqueous dispersions prepared in Examples 11-14 above, or purified water for comparison, followed by drying for 1 hour in a thermostatic chamber at 32°C. 1.5 g of PM2.5 particles (NIES-CRM No. urban airborne dust) were placed in a 4 cm square weighing dish. Each of the prepared Sapler was brought into contact with the PM2.5 particles, pressed with tweezers 10 times, and then shaken for 10 seconds after removal to remove excess PM2.5 particles. The PM2.5 particles adhering to each Sapler were then photographed and observed. The results are shown in Figure 10. It was confirmed that the adhesion of PM2.5 particles was suppressed in all of the samples to which the 0.05% by mass Pal-GH aqueous dispersion of Examples 11 to 14 had been dropped.

[0101] [Examples 3 and 5: Measurement of Moisture Adsorption and Desorption of Lipid Peptide Composition-Treated Hair] 30 mL of the Pal-GH aqueous dispersions of Examples 3 and 5, each containing 0.025% by mass of Pal-GH, was prepared. A strand (approximately 10 cm, approximately 1 g) of damaged hair (also referred to as bleached hair) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then rinsed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The resulting hair-treated samples were sheared to 1 cm lengths, and the moisture adsorption and desorption of each hair weighed 100 mg was evaluated using a DVS Adventure dynamic moisture adsorption and desorption analyzer. The hair was dried at 0% relative humidity for two days, and then the humidity was suddenly increased to 90% relative humidity, at which point the change in mass (% by mass) was measured. The above procedure was performed automatically using a program. The results are shown in Figure 11. It was confirmed that compared to damaged hair not treated with the lipid peptide solution, damaged hair treated with the 0.025% by mass Pal-GH aqueous dispersion of each of Examples 3 and 5 had reduced moisture adsorption.

[0102] Example 10: Measurement of Moisture Adsorption and Desorption of Lipid Peptide Composition-Treated Hair 30 mL of the Pal-GH aqueous dispersion of Example 10, each containing Pal-GH at a concentration of 0.005% by mass and 0.025% by mass, was prepared. Sodium dodecyl sulfate (SDS, Fujifilm Wako Pure Chemical Industries, Ltd.) was added to the dispersion to a concentration of 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The resulting hair-treated samples were then washed with water, towel-dried, and then dried overnight in a constant-temperature oven at 50°C. The moisture adsorption and desorption of each hair sample was evaluated using a dynamic moisture adsorption and desorption analyzer, DVS Adventure. The hair was dried at 0% relative humidity for two days, and the humidity was then suddenly increased to 90% relative humidity, at which point the change in mass (% by mass) was measured. The above procedure was performed automatically using a program. The results are shown in Figure 12. It was confirmed that the damaged hair treated with Example 10 had reduced moisture adsorption compared to the damaged hair not treated with the lipid peptide composition.

[0103] [Examples 1 and 2: Amount of Lipid Peptide Adhesion to Hair] 30 mL of Pal-GH aqueous dispersions of Examples 1 and 2, with Pal-GH concentrations of 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, were prepared from Preparation Examples 1 and 2. A bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant temperature bath at 50°C. The prepared hair-treated sample was sheared to 1 cm, 200 mg was weighed, placed in a 50 mL sample tube, and 10 mL of methanol was added. The sample was then sonicated for 1 hour to extract lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, manufactured by Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. The test was performed three times for each sample, and the average value was calculated. The results obtained are shown in Figure 13. It was confirmed that the amount of lipid peptide attached to the damaged hair treated in both Examples 1 and 2 increased in a concentration-dependent manner.

[0104] [Examples 3 to 5: Amount of Lipid Peptide Adhesion to Hair] 30 mL of Pal-GH aqueous dispersions of Examples 3 to 5, each with a Pal-GH concentration of 0.0025% by mass, 0.005% by mass, or 0.025% by mass, were prepared from Preparation Examples 3 to 5. A bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant temperature bath at 50°C. The prepared hair-treated sample was sheared to 1 cm, 200 mg was weighed, placed in a 50 mL sample tube, and 10 mL of methanol was added. The sample was then sonicated for 1 hour to extract the lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, manufactured by Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. The test was performed three times for each sample, and the average value was calculated. The results obtained are shown in Figure 14. It was confirmed that the amount of lipid peptide attached to the damaged hair treated in Examples 3 to 5 increased in a concentration-dependent manner.

[0105] [Examples 9 and 10: Amount of lipid peptide attached to hair] 30 mL of Pal-GH aqueous dispersions of Examples 9 and 10, with Pal-GH concentrations of 0.0025% by mass, 0.005% by mass, and 0.025% by mass, respectively, were prepared from Preparation Examples 9 and 10. A bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant temperature bath at 50 °C. The prepared hair-treated sample was sheared to 1 cm, 200 mg was weighed, placed in a 50 mL sample tube, and 10 mL of methanol was added. The sample was then sonicated for 1 hour to extract lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. The test was performed three times for each sample, and the average value was calculated. The results are shown in Figure 15. The adhesion of lipid peptides to damaged hair treated in Examples 9 and 10 was confirmed at all concentrations.

[0106] [Examples 16 and 17: Amount of lipid peptide and succinic acid deposited on hair when blended into shampoo and conditioner] Preparation Examples 1 and 2 were added to a commercially available shampoo (Botanist Botanical Shampoo Smooth) and conditioner (Botanist Botanical Conditioner Smooth), respectively, to prepare shampoo and conditioner of Examples 16 and 17 so that the Pal-GH concentration was 0.005% by mass, and succinic acid was blended therein so that the concentration was 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was washed with a 10-yen coin-sized amount of each shampoo, rinsed with water, and towel-dried. A 10-yen coin-sized amount of each conditioner was uniformly applied to the towel-dried hair, allowed to stand for 30 minutes, washed with water, towel-dried, and then dried overnight in a constant temperature bath at 50°C. The prepared hair treatment sample was sheared to 1 cm, and 200 mg was weighed and placed in a 50 mL sample tube. 10 mL of methanol was added, and the tube was sonicated for 1 hour to extract the lipid peptides and succinic acid that had penetrated and adhered to the hair. The extract was analyzed using a mass spectrometer LC / MS (Waters) to calculate the lipid peptides and succinic acid extracted from the hair. The results are shown in Figures 16 and 17. Figure 16 shows the amount of lipid peptides detected in the hair extract, and Figure 17 shows the amount of succinic acid detected in the hair extract. High penetration of lipid peptides and succinic acid was confirmed in both the damaged hair treated in Example 16 and Example 17.

[0107] [Examples 18 to 20: Amount of lipid peptide and succinic acid deposited on hair when blended into shampoo and conditioner] Preparation Examples 3 to 5 were added to a commercially available shampoo (Botanist Botanical Shampoo Smooth) and conditioner (Botanist Botanical Conditioner Smooth), and shampoo and conditioner of Examples 18 to 20 were prepared so that the Pal-GH concentration was 0.025% by mass, respectively, and succinic acid was blended therein so that the concentration was 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was washed with a 10-yen coin-sized amount of each shampoo, rinsed with water, and towel-dried. A 10-yen coin-sized amount of each conditioner was evenly applied to the towel-dried hair, allowed to stand for 30 minutes, washed with water, towel-dried, and then dried overnight in a constant temperature bath at 50°C. The prepared hair treatment sample was sheared to 1 cm, and 200 mg was weighed and placed in a 50 mL sample tube. 10 mL of methanol was added, and the tube was sonicated for 1 hour to extract the lipid peptides and succinic acid that had penetrated and adhered to the hair. The extract was analyzed using a mass spectrometer LC / MS (Waters) to calculate the amount of lipid peptides and succinic acid extracted from the hair. The results are shown in Figures 18 and 19. Figure 18 shows the amount of lipid peptides detected in the hair extract, and Figure 19 shows the amount of succinic acid detected in the hair extract. High penetration of lipid peptides and succinic acid was confirmed in all damaged hair treated in Examples 18 to 20.

[0108] [Example 5, Comparative Examples 6 and 7: Measurement of Hardness of Lipid Peptide Compositions] The Pal-GH compositions of Preparation Example 5 and Comparative Preparation Examples 6 and 7 were subjected to breaking strength measurement using a YAMADEN RHEONER II CREEP METER RE2-33005B (Yamaden Co., Ltd.) at a measurement speed of 1 mm / sec, a measurement strain rate of 80%, a storage pitch of 0.10 sec, and a jig model 30349-3. The results are shown in Figure 20. This suggests that the Pal-GH composition of Preparation Example 5 shown in Example 5 has a higher hardness than the Pal-GH compositions of Comparative Preparation Examples 6 and 7 shown in Comparative Examples 6 and 7.

[0109] [Example 5, Comparative Examples 4 to 7: Contact Angle Measurement of Lipid Peptide Composition] The Pal-GH compositions and water obtained in Preparation Example 5 and Comparative Preparation Examples 4 to 7 above were weighed, and the Pal-GH compositions were added to a 200 mL beaker (manufactured by HARIO Corporation) while stirring the water. The mixture was stirred at 200 rpm for 5 minutes and allowed to stand at room temperature to dilute the mixture 200-fold with water, preparing aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) for Example 5 and Comparative Examples 4 to 7, respectively. Si substrates (manufactured by Matsuzaki Manufacturing Co., Ltd., thickness 525±25 μm) were treated with hexamethyldisiloxane and cut into 2.5 cm x 2.5 cm pieces. 0.25 mL of each of the 200-fold diluted solutions was applied to the substrates and dried in a constant temperature bath at 32°C for 20 hours. The contact angle was measured when a 2 μL droplet of water was placed on the dried film using a fully automatic contact angle meter (DM-701, manufactured by Kyowa Interface Science Co., Ltd.). The contact angle was also measured over time, at 0.01 minutes, 1.01 minutes, and 3.01 minutes after droplet deposition. The results are shown in FIG. 22. As shown in FIG. 22, Example 5 maintained the highest contact angle. The film formed from Example 5 has high water resistance, and is expected to have the effect of reducing damage, etc., associated with water adsorption when applied to hair, for example.

[0110] [Example 5, Comparative Examples 4 and 5: Structural Analysis of Pal-GH Compositions by Small-Angle X-ray Scattering (SAXS)] The results of structural analysis of Example 5 (Pal-GH composition obtained in Preparation Example 5), Comparative Example 4 (Pal-GH composition obtained in Comparative Preparation Example 4), and Comparative Example 5 (Pal-GH composition obtained in Comparative Preparation Example 5) by measurement using small-angle X-ray scattering (SAXS) are shown in FIG. 23. From FIG. 23, it can be seen that q=0.1 Å －１ With respect to the intensity in the vicinity, Example 5 had a profile different from those of Comparative Examples 4 and 5, indicating that the self-assembly patterns formed were different.

[0111] [Example 5, Comparative Examples 4 and 5: Structural Analysis of Aqueous Dispersions of Pal-GH Composition (Diluted 200 Times) by SAXS Method] The Pal-GH compositions obtained in Preparation Example 5 and Comparative Preparation Examples 4 and 5 above and water were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred at 200 rpm for 5 minutes and allowed to stand at room temperature to dilute the mixture 200 times with water, thereby preparing aqueous dispersions of the Pal-GH composition (also referred to as Pal-GH aqueous dispersions) as Example 5, Comparative Examples 4 and 5, respectively. The results of structural analysis of the Pal-GH aqueous dispersions of Example 5, Comparative Example 4 and Comparative Example 5 by measurement using the SAXS method are shown in FIG. 24. From FIG. 24, it is clear that q=0.1 Å －１ With respect to the intensity in the vicinity, Example 5 had a profile different from those of Comparative Examples 4 and 5, indicating that the self-assembly patterns formed were different.

Claims

1. A composition comprising a lipid peptide-type compound in which a peptide portion formed by repeating at least two or more identical or different amino acids is bound to a lipid portion consisting of an aliphatic group having 10 to 24 carbon atoms, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water.

2. The composition of claim 1, wherein the sucrose ester is sucrose polystearate or sucrose stearate.

3. The composition of claim 2, wherein the 1,2-alkanediol is 1,2-pentanediol or 1,2-hexanediol.

4. The composition according to claim 3, characterized in that the lipid peptide type compound consists of at least one of the compounds represented by the following formulas (1) to (3) or pharmaceutically acceptable salts thereof: (In the formula, R １ represents an aliphatic group having 9 to 23 carbon atoms; R ２ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R ３ Ha-(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. (In the formula, R ４ represents an aliphatic group having 9 to 23 carbon atoms; R ５ ~R ７ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. (In the formula, R ８ represents an aliphatic group having 9 to 23 carbon atoms; R ９ ~R １２ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a 5-membered ring group or a 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.

5. The composition of claim 4, wherein said fatty acid is stearic acid.

6. The composition described in claim 5, wherein the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition.

7. The composition according to claim 5, wherein the content of the lipid peptide type compound is 0.001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition, the content of the sucrose ester is 0.0005% by mass or more and 0.25% by mass or less, relative to the total mass of the composition, the content of the 1,2-alkanediol is 0.0014% by mass or more and 0.7% by mass or less, relative to the total mass of the composition, and the content of the fatty acid is 0.0001% by mass or more and 0.05% by mass or less, relative to the total mass of the composition, and the composition is a transparent dispersion at a temperature of 0°C or more and 40°C or less.

8. The composition according to claim 7, wherein the lipid peptide type compound is palmitoyl-Gly-His.

9. The composition described in claim 5, wherein the content of the lipid peptide type compound is 1.0 mass % or more and 20.0 mass % or less relative to the total mass of the composition.

10. A composition comprising a lipid peptide-type compound having a content of 4.0% by mass or more and 6.0% by mass or less, a sucrose ester having a content of 2.0% by mass or more and 3.0% by mass or less, and a 1,2-alkanediol having a content of 5.6% by mass or more and 8.4% by mass or less, and a fatty acid having a content of 0.4% by mass or more and 0.6% by mass or less, and a breaking strength of 2.0 to 4.0 x 10 ５ The composition of claim 5, wherein the 11. The composition according to claim 10, wherein the lipid peptide type compound is palmitoyl-Gly-His.

12. A cosmetic comprising the composition described in claim 5, wherein the content of the lipid peptide type compound is 0.0001% by mass or more and 5.0% by mass or less relative to the total mass of the cosmetic.

13. A method for reducing hair damage, comprising the steps of applying the cosmetic composition according to claim 12 to hair, and forming a film.

14. A method for improving the water resistance of hair, comprising the steps of applying the cosmetic composition according to claim 12 to hair and forming a film.

15. The method according to claim 13 or 14, wherein the lipid peptide type compound is palmitoyl-Gly-His.

16. A method for producing the composition described in claim 5, comprising the steps of mixing the components of the composition described in claim 5 so that the content of the lipid peptide type compound is 1.0 mass% or more and 20.0 mass% or less relative to the total mass of the composition, stirring at room temperature or heated, and allowing to cool to obtain a solid composition.

17. A method for producing a dispersion of a lipid peptide compound, comprising the steps of: mixing the components of the composition according to claim 5 and stirring at room temperature or with heating to produce a composition in which the content of the lipid peptide compound obtained is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; and mixing the composition with water and stirring at room temperature or with heating to produce a liquid composition in which the content of the lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less.

18. A method for producing a cosmetic, comprising the following steps: A step of mixing the components of the composition according to claim 5 and stirring the mixture at room temperature or while heated to produce a composition in which the content of the lipid peptide type compound is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition; A step of storing the obtained composition at room temperature or a low temperature; A step of mixing the composition with water and stirring the composition at room temperature or while heated to produce a composition in which the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, and storing the obtained composition at room temperature or a low temperature; And A step of mixing the composition with water, various solvents, and other additives without heating and stirring the composition at room temperature or a low temperature to produce a cosmetic in which the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the cosmetic.

19. A method for producing a cosmetic, comprising the following steps: A step of mixing the components of the composition according to claim 5 and stirring the mixture at room temperature or under heating to produce a composition in which the content of the lipid peptide type compound obtained is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; A step of storing the obtained composition at room temperature or at a low temperature; And A step of heating the composition, mixing it with various solvents and other additives, and stirring the mixture to obtain a cosmetic in which the content of the lipid peptide type compound is 0.0001% by mass or more and 5.0% by mass or less, relative to the total mass of the cosmetic.

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