Analgesia administration regulation and control system

Abstract

The present invention relates to an analgesia administration regulation and control system. The system comprises a hand grip, an analgesic drug delivery device connected to the hand grip, and an information processing unit. The system is further provided with a uterine contraction detection module and an electroencephalogram signal detection module. Upon receiving a request signal sent by a patient request unit, the information processing unit generates, on the basis of brain information presented by the electroencephalogram signal detection module, a drug injection amount corresponding to the brain information, wherein limited by an original biological potential signal related to uterine muscle contraction presented by the uterine contraction detection module, the drug injection amount adjusted on the basis of the brain information is adjusted within a division range that matches the uterine contraction rhythm reflected by the original biological potential signal. The present application generates an injection control signal comprising an injection type and an injection amount using a uterine contraction state as a body objective reference factor of a parturient woman, and adjusts a point value within an injection amount range on the basis of a subjective factor using the pressure of the parturient woman as main reference information.

Description

A pain medication dosing regulation system TECHNICAL FIELD

[0001] The present application relates to the technical field of injection pump, and particularly relates to a pain medication dosing regulation system. BACKGROUND

[0002] Each woman has significant differences in physiological characteristics and pain tolerance, which makes it difficult for traditional analgesia or drug delivery systems to effectively respond. Childbirth is a complex and dynamic process, and the needs of the woman change throughout the process. As the labor progresses, the woman's drug tolerance can also change. For example, in the first stage of labor, some women may respond well to low doses of medication, but in the second stage of labor, as the intensity of contractions increases, the same dose may no longer be sufficient. Existing analgesia systems often cannot monitor and adapt to these changes in tolerance in real time, resulting in unstable analgesia effects. For example, Siyoum, M., & Mekonnen, S. in 2019 published "Labor pain control and associated factors among women who gave birth at Leku primary hospital, southern Ethiopia" (see BMC research notes, 12(1), 619) explored the perception and control of labor pain among different women, and found that there were individual differences in the control of labor pain, and also found that the perception of labor pain control was affected by the progress of labor. Some women may have a strong pain response to mild contractions, while others may show significant pain under more intense contractions. This individual difference is not only reflected in the perception of pain, but also involves other physiological parameters such as heart rate, blood pressure, respiratory rate, etc. Kuhn, J.C., Falk, RS., & Langesaeter, E. in 2017 published "Haemodynamic changes during labour: continuous minimally invasive monitoring in 20 healthy parturients" (see International journal of obstetric anesthesia, 31, 74-83.) monitored the hemodynamics of women during childbirth, and found that in the two stages of labor, the hemodynamic pressure during systole was greater, especially in the second stage of labor, and there were certain fluctuations in the monitoring items such as cardiac output, stroke volume, heart rate, systolic blood pressure, and systemic vascular resistance.In addition, Wu, Y., Chu, Y., Zhao, X., Wang, X., Chen, L, Duan, R., Li, Y., & Liu, X. in 2024 published The Chinese version of rating scale of pain expression during childbirth (see (ESVADOPA): reliability and validity assessment. BMC nursing, 23(1), 520.) pointed out that the difference in pain assessment methods will affect the individual's response to pain, and there is a difference between the subjective assessment of pain and the objective assessment of pain. Due to the complex subjective nature of pain, the measurement of pain, especially the measurement of childbirth pain, is more challenging and specific than other vital sign measurements. US20140316371A1 discloses a computer-implemented method for controlling the dispensing of a biologically active agent, which technical solution relates to controlling the dispensing of a biologically active agent, particularly using a computer-implemented method in the management of labor pain. The method comprises: starting the intermittent dosage dispensing of the biologically active agent at a first background dosage rate; adjusting the background dosage rate according to the number of input signals received from the signal device. Although this technical solution can dynamically adjust the drug dosage according to the needs of the patient, it relies on the patient to express the pain needs through the signal device (such as a button). This self-reporting method may be affected by the patient's communication ability, cognitive state and pain tolerance, resulting in inaccurate input signals.

[0003] US20070233203A1 provides an obstetric analgesia system, which uses EHG signals and other monitoring means (such as fetal heart monitoring, uterine contraction monitoring, etc.) to predict the onset of uterine contraction, so as to automatically or through patient-controlled administration of analgesic drugs before uterine contraction causes pain. However, the assessment results of pain pressure related to pain management implementation or delivery method in this technical solution are relatively subjective, resulting in inaccurate input judgment signals. For example, CN111671505A also discloses an intelligent injection system and method, which adjusts the injection volume gear by the size of the cervix and the pain level. This application uses VAS score to assess the pain perception of the parturient. VAS score standard (pain level score standard) is a method of judging the severity of pain by visual simulation. The scoring standard usually uses a scale divided into 10 equal parts, with a score range of 0 to 10, where 0 represents no pain, 1-3 represents mild pain, 4-6 represents moderate pain, and 7-10 represents severe pain. The patient marks the position corresponding to the degree of pain he feels on the scale. However, due to the lack of control, the parturient often cannot clearly distinguish the specific pain level when the pain level reaches 5 or above, and there is a situation of randomly selecting pain levels or reporting high pain levels.

[0004] US20070299389A1 provides a system and method for optimizing the control of patient-controlled analgesia (PCA) and patient-controlled epidural analgesia (PCEA) systems. Since the threshold values of physiological parameters differ from individual to individual, the system cannot adapt to the physiological and tolerance differences of different individuals during use, especially for groups such as puerperae, and the system obviously cannot meet the adjustment requirements of body changes. CN115006678A discloses a drug concentration adjustable labor analgesia method and device, which comprises a handheld pressure sensing component, a uterine contraction monitoring component, a sound collecting component, a control component and an injection component. The technical solution measures the pain degree of the puerpera through the handheld pressure sensing component and the sound collecting component placed in the hand of the puerpera, detects the uterine contraction pressure through the uterine contraction monitoring component placed on the abdomen of the puerpera, stores different types of drugs by setting a drug bin, and controls the opening or closing of the valve provided on each drug bin according to the measurement results, so as to obtain mixed drugs of different concentrations. The technical solution can adjust the concentration of mixed drugs and the infusion amount of drugs according to the pain degree and uterine contraction pressure of the puerpera, thereby improving the effect of labor analgesia. However, the purpose of the pressure data and / or sound decibel data detection involved in the technical solution is to determine different pain levels, and different pain levels correspond to the use of different preferred drugs. The matching result of this setting method can only determine a single drug administration scheme, and the different detection data are only used to obtain a unique drug administration scheme. Once the drug administration scheme is determined, if the above detection data of the puerpera changes and the preset drug administration scheme needs to be adjusted, a new drug administration scheme must be determined again by combining a plurality of different detection data, and the drug administration scheme cannot be matched with the real-time update and adjustment of the actual physiological pain of the puerpera.

[0005] The analgesia systems provided by the prior art generally use static or semi-static drug administration schemes, which cannot respond to these dynamic changes in real time. For example, some systems may adjust the drug dose according to a preset time interval or a fixed uterine contraction frequency, but this cannot accurately reflect the actual needs of the puerpera. Therefore, when the uterine contraction is particularly strong or the emotional fluctuation is large, the puerpera may feel that the pain relief is insufficient, affecting the delivery experience. In addition, the prior art fails to provide a personalized analgesia scheme, which cannot be adjusted according to the physiological characteristics and pain tolerance of each puerpera. For example, some systems may set the same initial dose for all puerperae, ignoring the differences between individuals. SUMMARY

[0006] In view of these prior arts, the purpose of the present application is to determine the dynamic changes of drug needs of puerperae during delivery.

[0007] The present application also aims to provide an analgesic administration system for labor process, which obtains physiological characteristic difference and pain tolerance difference of a parturient by obtaining uterine contraction state of the parturient and information of emotional change of the parturient, so as to provide personalized administration strategy for different parturients.

[0008] Another object of the present application is also to integrate physiological index monitoring and drug demand of the parturient under the comprehensive reflection of pain stress, so as to avoid that the precondition of administration is too subjective. Specifically, the initial drug injection amount is generated according to the brain information matched with the brain information, and the initial drug injection amount is dynamically adjusted according to the presented raw bioelectric potential signal.

[0009] Still another object of the present application is to provide a handgrip for identifying the request signal sent by the parturient in the awake state, so as to obtain the handgrip of the parturient in the process accompanied by the increase of the uterine contraction degree, so as to reflect the real demand of the parturient for the drug.

[0010] The present application provides an analgesic administration control system. The system comprises a handgrip provided with a patient request unit, an analgesic drug delivery device connected with the handgrip and providing drug delivery to the parturient when the patient request unit delivers a request signal, and an information processing unit generating a signal of injection amount of the drug output by the analgesic drug delivery device based on the received information related to the parturient.

[0011] The system is also provided with a contraction detection module for collecting the contraction reflecting the pain rhythm of the parturient, and an electroencephalogram detection module for collecting the brain information reflecting the pain state of the parturient, wherein, when the request signal sent by the patient request unit is received, the information processing unit generates the drug injection amount corresponding to the brain information based on the brain information presented by the electroencephalogram detection module, wherein, limited by the raw bioelectric potential signal related to the uterine muscle contraction presented by the contraction detection module, the drug injection amount adjusted based on the brain information is adjusted within the divided range matched with the contraction rhythm reflected by the raw bioelectric potential signal.

[0012] Compared with the prior art, the present application can generate an initial drug injection amount matched with the brain information presented by the brain electrical signal detection module, and can simultaneously dynamically adjust the initial drug injection amount according to the original bioelectric potential signal related to uterine muscle contraction presented by the uterine contraction detection module. Based on the above-mentioned distinguishing technical features, the problem to be solved by the present application can include: how to dynamically adjust the injection amount of analgesic drugs according to different periods of uterine contraction rhythm during labor, so as to finely adjust the amount of analgesic drugs in response to the dynamically changing pain of the parturient woman. Specifically, the rhythm of uterine contraction during labor includes an intermittent period and a peak period, and the intensity of the contraction response gradually increases with the arrival of the labor time, thereby causing the patient to feel different degrees of pain. Therefore, the injection amount of analgesic drugs should also be dynamically adjusted according to the production process of the patient. The beneficial effects of the technical solution are as follows:

[0013] The prior art disclosed in the patent application with publication number CN111671505A uses the pain level and the size of the cervix mouth fed back by the feedback parameter receiving module to divide the injection mode and the injection parameter. Unlike the intelligent injection system disclosed in the prior art, the present application uses the uterine contraction state as an objective reference factor of the parturient woman to generate an injection control signal containing the injection type and the injection amount, and adjusts the point value within the injection amount range based on the subjective factor of the parturient woman's stress as the main reference information.

[0014] The objective factor of the parturient woman's body is a standard value reflecting the parturient woman's pain state, and the change of this state can be predicted by medical personnel and the corresponding analgesic means can be given based on the process change. Therefore, the present application reflects the pain rhythm based on the parturient woman's uterine contraction rhythm, and at the same time makes the analgesic drug delivery device provide the parturient woman with the corresponding drug delivery according to the preset rules.

[0015] Further, the subjective factor (or pain perception) of the parturient woman is affected by individual differences and shows differences. When the parturient woman requests delivery of analgesic drugs based on pain, individuals who feel more pain need higher doses of analgesic drugs to alleviate their pain. The patent application CN111671505A discloses a VAS scoring method to adjust the drug injection mode. However, the VAS scoring method requires the parturient woman to judge her perception while experiencing pain, which cannot eliminate the deviation caused by subjectivity. In particular, the parturient woman's head is not clear in the state of pain stimulated by progesterone, and the scoring given in this state has low reliability, which also makes the pain level assessment under the VAS scoring method unable to effectively adjust the drug delivery dose to alleviate the parturient woman's pain, or excessively increase the drug delivery dose at a time (since a large dose reduces the baseline value of pain, the parturient woman will only need a higher drug delivery dose to achieve the change in perception of pain relief, which reduces the experience of painless delivery for parturient women whose pain degree increases with the degree of uterine contraction in the later period).

[0016] Meanwhile, unlike the evaluation parameter of the size of the cervix opening disclosed in the CN111671505A patent application, the present application evaluates the injection type and injection amount of the analgesic drug based on the detection information of the uterine contraction rhythm. Since the cervix opening of the parturient gradually opens to more than ten centimeters in a long time (for example, 6-18 hours), and the change range in the early stage is small, using the cervix opening change as the reference data will reduce the maneuverability of the evaluation, and the change range of the evaluation result will be small, which cannot match the change of the real pain of the parturient. The present application takes the uterine contraction rhythm of the parturient as the reference index, and the uterine contraction rhythm is also the main basis for directly reflecting the pain rhythm of the parturient. With the change of the uterine contraction rhythm, the injection type and injection amount of the analgesic drug can be adjusted at the peak period or the intermittent period of each or several uterine contractions. In particular, the pain feeling brought by the intermittent period of the uterine contraction is smaller than that of the peak period, so the injection time will affect the analgesic feeling of the parturient.

[0017] According to a preferred embodiment, the brain information at least contains the brain electrical signals detected by the brain electrical detection electrodes of the brain electrical detection module, wherein the time domain and frequency domain of the brain electrical signals representing the brain activity are used to match the injection amount of the drug adjusted based on the brain information in a manner representing the stress state of the parturient.

[0018] According to a preferred embodiment, the information processing unit is configured to:

[0019] The regular waveform curve is formed based on the original bioelectric potential signal related to uterine muscle contraction collected by the uterine contraction detection module. When the regular waveform curve has a feature corresponding to the peak period of uterine contraction, a preset injection amount range is provided for the parturient to inject drugs, wherein the preset injection amount range is increased / decreased by a preset value according to the generation time node of the regular waveform curve corresponding to the peak period of uterine contraction as the driving basis for modifying the injection amount range. The prior art has appeared the technical solution of detecting uterine contraction state data to realize the parturient state judgment. For example, CN113018618A discloses a device for assisting anesthesia in clinical anesthesiology, which includes a breathing, blood oxygen, fetal movement, and uterine contraction pressure sensor for monitoring the physiological state of the parturient and the fetus. The main control unit receives all signals and analyzes and judges the state of the parturient. Based on different states, the main control unit controls the respirator to perform different modes of ventilation, sends in anesthetic gas, injects oxytocin, or enters the anesthetic drug preparation state. The technical solution calculates the uterine contraction pressure value through the uterine contraction pressure signal obtained by the uterine contraction pressure sensor, and performs corresponding treatment scheme regulation and control by monitoring the change of the uterine contraction pressure signal. However, the uterine contraction pressure data obtained in this technical solution is only limited to controlling the working mode of a single respirator, and cannot be superimposed on the basis of other detection data for fine adjustment of the analgesic drug injection amount. Further, the uterine contraction pressure value obtained in this technical solution can only be used to reflect the node parameter in the current state, and cannot be used to realize continuous and periodic treatment scheme regulation and control, so it is not possible to dynamically adjust the analgesic drug injection amount according to the physiological state data of the patient in different uterine contraction periods. Compared with the above prior art, the information processing unit of the present application can form a regular waveform curve according to the original bioelectric potential signal collected by the uterine contraction detection module, and can increase the injection amount according to the generation time node of the regular waveform curve corresponding to the peak period of uterine contraction. Based on the above technical features, the problem to be solved by the present application can include: how to dynamically adjust the analgesic drug injection amount according to the different uterine contraction peak period characteristics of the patient. Specifically, the cyclic drug administration in the present application is divided into a first dose of drug and a mixed drug. When the parturient enters the uterine contraction state and the parturient has regular uterine contraction for the first time, the parturient is injected with the first dose of drug at the peak period of uterine contraction. When the parturient has regular uterine contraction for the second time and subsequent times, the parturient is injected with the mixed drug at the peak period of uterine contraction, and the injection amount is increased by a preset injection amount with the increase of the number of uterine contractions, so as to realize the dynamic matching of the analgesic drug injection amount and the parturient uterine contraction state to reduce the pain of the parturient.

[0020] According to a preferred embodiment, the analgesic drug delivery device comprises a first drug liquid box and a second drug liquid box driven by the driven module, wherein the first drug liquid box and the second drug liquid box respectively place different types of drugs.

[0021] According to a preferred embodiment, based on the first occurrence of the regular waveform curve formed by the raw bioelectric potential signals associated with uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit controls the driving module of the analgesic drug delivery device to drive the second liquid cartridge to inject the first dose of drug into the parturient at a preset content, wherein, under the control of the request signal sent by the patient request unit and the brain information representing the stress state of the parturient, the information processing unit sends the drug delivery signal to the analgesic drug delivery device to control the second liquid cartridge and the first liquid cartridge to supply drugs at a preset ratio.

[0022] Preferably, the first liquid cartridge and the second liquid cartridge of the analgesic drug delivery device are respectively placed with ropivacaine and sufentanil, wherein, based on the first occurrence of the regular waveform curve formed by the raw bioelectric potential signals associated with uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit controls the driving module of the analgesic drug delivery device to drive the second liquid cartridge placed with sufentanil to inject the first dose of drug into the parturient at a preset content, wherein, under the control of the request signal sent by the patient request unit and the brain information representing the stress state of the parturient, the information processing unit sends the drug delivery signal to the analgesic drug delivery device to control the second liquid cartridge placed with sufentanil and the first liquid cartridge placed with ropivacaine to supply drugs at a preset ratio.

[0023] According to a preferred embodiment, based on the non-first occurrence of the regular waveform curve formed by the raw bioelectric potential signals associated with uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit controls the driving module of the analgesic drug delivery device to drive the second liquid cartridge and the first liquid cartridge to inject drugs during the uterine contraction cycle at a preset ratio, wherein the injection amount of the liquid mixture generated by the second liquid cartridge and the first liquid cartridge at a preset ratio is increased in accordance with a preset increase value driven by the generation time node of the regular waveform curve in accordance with the characteristics of the peak period of uterine contraction.

[0024] Preferably, based on the non-first occurrence of the regular waveform curve formed by the raw bioelectric potential signals associated with uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit is configured to:

[0025] control the driving module of the analgesic drug delivery device to drive the second liquid cartridge placed with sufentanil and the first liquid cartridge placed with ropivacaine to inject drugs during the uterine contraction cycle at a preset ratio.

[0026] According to a preferred embodiment, based on the non-first occurrence of the regular waveform curve formed by the raw bioelectric potential signals associated with uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit is configured to:

[0027] The drug injection amount in the first drug liquid box or the second drug liquid box is increased according to a preset increase value under the control of the request signal sent by the patient request unit and the brain information representing the stress state of the parturient.

[0028] Preferably, based on the regular waveform curve formed by the original bioelectric potential signals related to the uterine muscle contraction collected by the contraction detection module in accordance with the characteristics of the peak period of uterine contraction, the information processing unit is configured to:

[0029] The drug injection amount in the first drug liquid box or the second drug liquid box is increased according to a preset increase value under the control of the request signal sent by the patient request unit and the brain information representing the stress state of the parturient.

[0030] According to a preferred embodiment, the handgrip comprises an elastic shell, at least two elastic support rods arranged in a cross inside the elastic shell, and a pressure sensor arranged at the center of the cross of the elastic support rods and capable of sensing the pressure value of the corresponding elastic support rod, wherein when the pressure value transmitted by the pressure sensor exceeds a preset threshold value, the spring decompressor arranged at one end of the elastic support rod for adjusting the spring compression range of the elastic support rod is controlled by the information processing unit to decompress the spring, so that the fingers of the parturient stretch with the expansion of the elastic shell.

[0031] According to a preferred embodiment, the patient request unit comprises a vibration sensor to identify the tapping behavior of the parturient in a conscious state for sending a request signal to the analgesic drug delivery device.

[0032] According to a preferred embodiment, at least one finger sleeve is arranged on the surface of the elastic shell, wherein the area corresponding to the at least one finger sleeve is provided with a vibration sensor capable of sensing the tapping behavior generated by the corresponding area. BRIEF DESCRIPTION OF DRAWINGS

[0033] Fig. 1 is a use state diagram of the pregnant woman in a lying position provided by the present application;

[0034] Fig. 2 is a use state diagram of the pregnant woman in a sitting position provided by the present application;

[0035] Fig. 3 is a functional structure diagram of the guidance module provided by the present application;

[0036] Fig. 4 is a functional structure diagram of the guidance module in another embodiment provided by the present application;

[0037] Fig. 5 is a perspective view of the handgrip provided by the present application;

[0038] Fig. 6 is a perspective view of another embodiment of the handgrip provided by the present application;

[0039] Fig. 7 is an internal structure diagram of the handgrip provided by the present application;

[0040] Fig. 8 is a system flowchart provided by the present application;

[0041] Fig. 9 is a flowchart of a method for relieving pain provided by the present application.

[0042] List of reference signs 100: analgesic drug delivery device; 110: driving module; 120: first drug solution box; 130: second drug solution box; 200: handgrip; 210: patient request unit; 211: vibration sensor; 220: pressure assembly; 221: elastic support rod; 222: spring compressor; 223: pressure sensor; 230: emotional information acquisition unit; 231: voice recognizer; 232: player; 240: elastic shell; 250: elastic wrist rope; 251: button; 252: ring; 260: finger sleeve; 300: electroencephalogram signal detection module; 310: electroencephalogram detection electrode; 320: first filter amplifier circuit; 400: uterine contraction detection module; 410: potential signal acquisition unit; 500: information processing unit; 600: physiological parameter detection module. DETAILED DESCRIPTION

[0043] The present application will be described in detail below with reference to the accompanying drawings.

[0044] In the description of the present application, the terms "first" and "second" are only used for the purpose of description, and should not be understood as indicating or implying relative importance. In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "provided with", "connected" and the like should be understood in a broad sense, for example, "connected" can be fixed connection, or detachable connection, or integral connection; can be directly connected, or indirectly connected through an intermediate medium; can be internal communication of two elements. The meaning of "several" is two or more, unless otherwise explicitly specified and limited. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0045] Embodiment 1

[0046] The present embodiment provides a system for regulating the labor pain of a parturient during the labor process, which regulates the administration of different drug amounts and drug types to reduce the pain of the parturient.

[0047] One aspect of the present application relates to an analgesic drug administration regulation system. Figs. 3 and 4 show the functional structure diagram of the present system. In the application, the handgrip 200, the electroencephalogram signal detection module 300, the analgesic drug delivery device 100 and the uterine contraction detection module 400 can establish a communication connection, such as data, signals and / or control signals, through a wireless network (such as Bluetooth, WIFI, Zigbee, etc.).

[0048] Another aspect of the present application relates to a painkilling drug delivery device 100. The painkilling drug delivery device 100 is capable of establishing a drug delivery relationship with a parturient through puncture or other means. Preferably, the painkilling drug delivery device 100 is capable of delivering at least one anesthetic drug to the parturient through an epidural catheter left in the intervertebral space.

[0049] Specifically, as shown in FIG. 1 and FIG. 3, the painkilling drug delivery device 100 comprises a first drug cartridge 120, a second drug cartridge 130, a communication module and a driving module 110. The communication module is capable of receiving a drug delivery signal sent by the information processing unit 500. The driving module 110 is capable of driving the flow of the drug in the first drug cartridge 120 and the second drug cartridge 130 simultaneously, and is also capable of driving the flow of the drug in the first drug cartridge 120 or the second drug cartridge 130 individually, such as a PCA pump (patient-controlled analgesia pump).

[0050] Preferably, the first drug cartridge 120 and the second drug cartridge 130 respectively place different types of drugs, for example, the first drug cartridge 120 places ropivacaine; the second drug cartridge 130 places sufentanil.

[0051] Another aspect of the present application relates to a uterine contraction detection module 400. The uterine contraction detection module 400 comprises a potential signal acquisition unit 410 and a power supply unit for powering the potential signal acquisition unit 410. Preferably, as shown in FIG. 1 and FIG. 2, during the process of painless delivery of a parturient, the potential signal acquisition unit 410 is in the form of an electrode patch attached to the upper abdomen of the parturient to acquire the myoelectric signal of the uterus, such as EMG. The uterine contraction detection module 400 is capable of transmitting the acquired signal to the information processing unit 500 to obtain the fluctuation state of the uterus during uterine contraction.

[0052] Specifically, the waveform curve composed of the signal representing the uterine contraction state acquired by the potential signal acquisition unit 410 comprises a regular waveform curve and an irregular waveform curve. The system involved in the present application is capable of distinguishing whether the parturient enters the state of labor based on the regularity of the waveform curve, that is, to identify the authenticity of the uterine contraction state. Since false contractions belong to the phenomenon of false labor of parturients, in the current common sense of pregnancy, in order to avoid the parturient losing the perception of true contractions, the injection of painkilling drugs, especially the injection mode of intraspinal labor analgesia, is required to be avoided as much as possible. Since the parturient before labor (especially the parturient who gives birth for the first time) may have the phenomenon of false contractions before the occurrence of true contractions, it is necessary to distinguish the timing of the first injection of painkilling drugs through the waveform curve.

[0053] The rhythm of uterine contractions includes an intermittent period and a peak period, and gradually increases the intensity of contraction response with the arrival of the time of labor. Therefore, the injection amount of painkilling drugs should not be constant.

[0054] In the present application, the information processing unit 500 is driven by the generation time node of the regular waveform curve conforming to the characteristics of the peak period of uterine contraction, and the injection amount will increase as the uterine contraction progresses. Preferably, the injection amount will increase by a preset increase value every time the regular waveform curve conforming to the characteristics of the peak period of uterine contraction is generated. Preferably, since the injection amounts of different drugs are different, the increase (preset increase value) of the injection amount involved in the present application can include the increase of the injection amount of a single drug.

[0055] At the same time, the rhythm of uterine contraction, i.e. the interval period and the peak period, also needs to be concerned. The administration method in labor analgesia generally includes cyclic administration and on-demand administration, i.e. based on the rhythm of uterine contraction, the patient is injected with drugs of a preset injection amount and drug category during the peak period of uterine contraction. Since the uterine contraction is a regular change state with gradually increasing peak value, this type of administration is called cyclic administration.

[0056] In the present application, the applicant divides the cyclic administration into first dose drugs and mixed drugs based on years of obstetric anesthesia experience. When the patient has the first regular uterine contraction, the patient is injected with 5 μg sufentanil during the peak period of uterine contraction. At the same time, an injection amount of 0.3 μg / mL sufentanil + 0.1% ropivacaine is set to provide drug delivery to the patient at the injection amount determined by the information processing unit 500 when the patient requests injection. When the patient has the second and subsequent regular uterine contractions, the patient is injected with a drug mixture of 0.3 μg / mL sufentanil + 0.1% ropivacaine during the peak period of uterine contraction, and the injection amount increases by a preset injection amount as the number of contractions increases, and the patient is provided with single drug delivery at the injection amount determined by the information processing unit 500 when the patient requests injection.

[0057] It should be noted that in order to ensure the stability of the blood concentration of the anesthetic drugs of the patient, the injection amount of 0.3 μg / mL sufentanil + 0.1% ropivacaine cannot exceed 5 mL every 20-30 minutes since the regular uterine contraction begins.

[0058] Another aspect of the present application relates to an electroencephalogram signal detection module 300. The electroencephalogram signal detection module 300 comprises an electroencephalogram detection electrode 310, a first filter-amplifier circuit 320 and a power supply unit, as shown in FIG. 3 and FIG. 4. The electroencephalogram signal detection module 300 can be set as a wearable device, and is connected to the information processing unit 500 in a wireless manner. When the parturient enters labor, the electroencephalogram signal detection module 300 worn on the head of the parturient does not affect the auxiliary operation of the medical staff on the parturient during labor, nor does it affect the behavior of the parturient when she exercises off the bed to relieve the pain of uterine contraction, as shown in FIG. 2. When the electroencephalogram detection electrode 310 collects an electroencephalogram signal, such as EEG, the electroencephalogram signal detection module 300 sends the collected signal to the information processing unit 500 through the screening and adjustment of the first filter-amplifier circuit 320, so as to generate information for judging the stress state of the parturient. Preferably, the electroencephalogram signal detection module 300 can be an electroencephalogram (EEG) device disclosed in CN107690308B, a multi-channel portable EEG device (such as Emotiv EPOC X), etc.

[0059] Another aspect of the present application relates to an information processing unit 500. The information processing unit 500 can be set as an integrated device integrated on the handgrip 200 or the analgesic drug delivery device 100, or it can be set as a separate device. Preferably, the information processing unit 500 can be a smart phone, a smart watch or other wearable device, a tablet computer, a computer, a cloud server or other smart device with CPU and communication module. The CPU receives the detection signals sent from the electroencephalogram signal detection module 300, the uterine contraction detection module 400, the handgrip 200 or the physiological parameter detection module 600 with blood oxygen, blood pressure and heart rate detection functions through the communication module, and converts the detection signals into processable data, which is used to further generate signals for controlling the analgesic drug delivery device 100.

[0060] Another aspect of the present application relates to a handgrip 200. The handgrip 200 comprises an elastic shell 240 and a patient request unit 210, a power supply unit and a pressure assembly 220.

[0061] Specifically, as shown in FIG. 7, the pressure assembly 220 comprises at least two elastic support rods 221 arranged in a cross inside the elastic shell 240, and a pressure sensor 223 arranged at the center of the intersection of the elastic support rods 221 and capable of sensing the pressure value of the corresponding elastic support rod 221. The elastic support rod 221 is connected with the elastic shell 240 through a spring compressor 222. Based on a preset pressure value, the spring compressor 222 adjusts the elastic force of the elastic support rod 221, so that the handgrip 200 matches the grip strength of the parturient.

[0062] With the increase of the degree of uterine contraction (or the increase of the degree of pain), the grip of the mother will gradually increase. When the pressure value transmitted by the pressure sensor 223 exceeds the preset threshold value, the spring decompressor 222 arranged at one end of the elastic support rod 221 for adjusting the spring compression range of the elastic support rod 221 is controlled to decompress the spring by the information processing unit 500. The spring is sleeved on the elastic support rod 221, and after the spring is decompressed, the length of the elastic support rod 221 is increased, that is, the expanded elastic shell 240 after decompression, and the bending degree of the fingers of the mother holding the handgrip 200 is reduced. At this time, the fingers of the mother stretch with the expansion of the elastic shell 240.

[0063] The handgrip 200 is also provided with a vibration sensor 211. Since the mother in a state of pain cannot control herself, her hands will unconsciously apply pressure to the object in the palm. The pain pump controller in the prior art is basically a thumb pressing device, which also causes the mother in a state of pain to unconsciously press repeatedly, so that the pain pump basically provides the mother with the maximum output of painkillers, and the effect of the system setting based on the state of the mother is not obvious. Therefore, the patient request unit 210 of the present application is set as a component of the signal sending mode of the tapping type, that is, the patient request unit 210 includes a vibration sensor 211 to identify the tapping behavior of the mother in a state of sending a request signal to the painkiller delivery device 100, as shown in FIGS. 1 and 6.

[0064] In order to accurately locate the tapping area, the elastic shell 240 of the present application is provided with one of the following two structures on the surface.

[0065] The surface of the elastic shell 240 is provided with at least one finger sleeve 260, wherein the area corresponding to the at least one finger sleeve 260 is provided with a vibration sensor 211 capable of sensing the tapping behavior generated in the area corresponding thereto, as shown in FIG. 5.

[0066] The surface of the elastic shell 240 is provided with a rebound wrist connecting rope 250. One end of the rebound wrist connecting rope 250 is provided with an adjusting unit including a spring and a locking component, and the other end is provided with a ring 252 sleeved on the wrist of the mother. Preferably, the structure of the adjusting unit can be the same as the telescopic structure of the telescopic traction rope, or the same as the automatic telescopic structure of the tape measure. When the mother needs to get out of bed to relieve the pain of uterine contraction, the mother can put down the handgrip 200, and the handgrip 200 is suspended, as shown in FIG. 2, and the mother can support the wall with both palms to complete the relevant action.

[0067] After getting back to bed, the handgrip 200 is rebounded into the hand by pressing the button 251 to regain control of the painkiller delivery device 100. Preferably, the button 251 can be arranged on the ring 252 or the surface of the elastic shell 240.

[0068] According to a preferred embodiment, the analgesic regulation system involved in the present application is located in the clinical information system of the hospital, and can be connected to the hospital information system.

[0069] Specifically, when the parturient emergency enters the hospital or is judged to enter the labor in the ward, based on the occurrence of the parturient entering the delivery room, the obstetrician intelligent device (such as an obstetrician mobile phone) in the clinical information system is connected to the analgesic regulation system, and the obstetrician can remotely send an instruction to the information processing unit 500 through the communication module in the obstetrician intelligent device equipped by himself before he arrives at the delivery room, and the midwife has arrived, based on the medical history of the parturient, to adjust the initial dose value of the analgesic drug delivery device 100 in the delivery room.

[0070] In this process, since the use of analgesic drugs is monitored (such as supervision of the use dose, and the used analgesic drug bottle needs to be recycled), the information processing unit 500 can record the analgesic drug use dose of the analgesic drug delivery device 100, and send it to the hospital information system, to check whether the amount of recycled analgesic drugs is correct.

[0071] Embodiment 2

[0072] This embodiment provides an analgesic administration regulation method for parturients in a stress state. In this embodiment, taking the CPU integrated on the handgrip 200 as an example, as shown in FIG. 3, except that the control method of the information processing unit 500 to the analgesic drug delivery device 100 is different, the other hardware is the same as the previous embodiment.

[0073] The potential signal acquisition unit 410 of the uterine contraction detection module 400 acquires the raw bioelectric potential signal of the parturient on the abdomen of the parturient. After receiving the signal sent by the uterine contraction detection module 400, the information processing unit 500 of the handgrip 200 analyzes the uterine contraction state of the parturient by using the model disclosed in CN109875556B. When the waveform curve formed by the raw bioelectric potential signal of the parturient first appears regular fluctuations, the information processing unit 500 of the handgrip 200 generates an instruction for the analgesic drug delivery device 100 to inject 5 μg of sufentanil into the parturient at the peak period of the uterine contraction. Subsequently, during the uterine contraction period of the current uterine contraction or several cycles, when the parturient taps the handgrip 200 to make the vibration sensor 211 of the handgrip 200 generate a request signal sent to the information processing unit 500, the information processing unit 500 analyzes the scaling index a of the electroencephalogram signal acquired by the electroencephalogram signal detection module 300, as shown in FIG. 8. The scaling index includes data for showing the emotional changes of the parturient, which characterizes the amplitude of the electroencephalogram signal. For example: the scaling index includes the time domain or frequency domain of the electroencephalogram signal. The time domain refers to extracting the information contained therein by analyzing the time sequence of the electroencephalogram signal. Common time domain features include: average amplitude, variance, slope, peak time, maximum and minimum value, etc. The frequency domain feature refers to extracting the frequency characteristic information contained therein by frequency analysis of the electroencephalogram signal. Common frequency domain features include: wave frequency, power spectral density, energy spectrum, absolute / relative normalized power, spectral bandwidth, etc.

[0074] Taking the wave frequency of the electroencephalogram signal as an example, when the scaling index a is lower than the preset threshold value, the information processing unit 500 controls the analgesic drug delivery device 100 to provide the parturient with a first preset injection amount of 0.3 μg / mL of sufentanil + 0.1% ropivacaine.

[0075] When the scaling index a is higher than the preset threshold value, the information processing unit 500 controls the analgesic drug delivery device 100 to provide the parturient with a second preset injection amount of 0.3 μg / mL of sufentanil + 0.1% ropivacaine.

[0076] Preferably, the first preset injection amount is less than the second preset injection amount.

[0077] Compared with the VAS score generated by relying on the parturient's own feelings, the present application uses objective parameters (such as physiological parameters) to judge the subjective feelings (pain perception) of the parturient, avoiding the occurrence of the situation that the parturient cannot distinguish the specific pain level when the pain level reaches 5 or more due to the lack of control.

[0078] Embodiment 3

[0079] The analgesic method provided in this embodiment is realized based on the system provided in embodiment 1. The analgesic method based on the analgesic drug delivery control system includes the following steps.

[0080] The medical staff connects the analgesic administration regulation system to the hospital's clinical information system (CIS) and inputs the basic information of the parturient (such as age, weight, height, pregnancy history, etc.). The medical staff puts the electroencephalogram signal detection module 300 on the parturient, ensuring that the electrodes are attached to the appropriate position on the parturient's head to collect accurate brain wave signals. The medical staff attaches the potential signal acquisition unit 410 of the uterine contraction detection module 400 to the parturient's abdomen, ensuring that it can monitor the uterine muscle contraction in real time. The medical staff gives the parturient the handgrip 200 and guides the parturient on how to use the patient request unit 210. The handgrip 200 is worn on the parturient's hand, ensuring that it can send a request signal at any time when it feels pain. The uterine contraction detection module 400 begins to collect raw bioelectric potential signals reflecting uterine muscle contraction in real time and transmits the data to the information processing unit 500. The information processing unit 500 analyzes the collected waveform curve to determine whether the contraction is regular. The information processing unit 500's analysis of whether the contraction is regular includes: calculating the frequency of the contraction to determine whether there is a stable periodic change; assessing the intensity of each contraction to observe whether there is a gradually increasing trend; measuring the duration of each contraction to determine whether it is gradually lengthening; assessing the symmetry of the waveform to determine whether there is a uniform rising and falling trend. If the information processing unit 500 determines that the waveform curve is irregular, the system identifies it as a false contraction and continues to monitor. At this time, the system will not start the analgesic drug injection program. If the information processing unit 500 determines that the waveform curve is regular, the system identifies it as a true contraction and proceeds to the next step of operation. When the peak period characteristic of the contraction appears again, the information processing unit 500 obtains a regular waveform curve and determines the time node of this contraction, and the system records these time nodes and provides a time framework for subsequent drug delivery, making the delivery more targeted. The analgesic method of this embodiment is shown in FIG. 9.

[0081] When the system first identifies the peak period of true contraction, the information processing unit 500 generates a control signal to control the analgesic drug delivery device 100 to inject the first dose of drug into the parturient. The first dose of drug usually contains 5 μg of sufentanil to quickly relieve the initial pain of the parturient. The drug is delivered into the parturient's body through an epidural catheter. The information processing unit 500 records the time node of the first contraction and begins to monitor the frequency and intensity changes of subsequent contractions. In this embodiment, the analgesic drug can also include fentanyl, bupivacaine (suitable for cases that require long-term analgesia, such as the second stage of labor or cesarean section surgery), lidocaine, tetracaine, tramadol, nalbuphine, etc., and the administration is adjusted according to the actual situation of the clinic, the doctor's advice and the feedback of the parturient.

[0082] In this embodiment, the analgesic drug delivery device 100 comprises a driving module 110, a first drug cartridge 120 and a second drug cartridge 130. The driving module 110 is the core component for controlling the drug delivery. The first drug cartridge 120 is used to store one kind of analgesic drug (e.g. bupivacaine). The second drug cartridge 130 is used to store another kind of analgesic drug (e.g. fentanyl). Before delivery, the medical staff connects the analgesic drug delivery device 100 to the parturient and ensures that the first drug cartridge 120 and the second drug cartridge 130 are filled with appropriate analgesic drugs respectively. Before the device is started, necessary system self-checking is performed to ensure that the drug delivery system is working properly. The driving module 110 calculates the optimal injection ratio of the two drugs according to the set algorithm to ensure that the analgesic effect is maximized and the risk of side effects is reduced.

[0083] Through the patient request unit 210, the parturient can actively request analgesia. After the driving module 110 receives the request signal, the drug delivery is started. For example, the first drug cartridge 120 starts the delivery of bupivacaine according to the set dose and injection speed, and the initial dose is 0.25%-0.5% bupivacaine injected at 10-15 mL. The second drug cartridge 130 simultaneously starts the delivery of fentanyl to enhance the analgesic effect, and the specific dose is 1-2 μg / kg, which is adjusted according to the specific response of the parturient.

[0084] In this embodiment, according to the detected regular waveform curve and the characteristics of the peak period of uterine contraction, the information processing unit 500 calculates the preset ratio of drug delivery, for example, the ratio of bupivacaine and fentanyl is set to 1:1, and the second drug cartridge 130 and the first drug cartridge 120 are driven by the driving module 110 to inject drugs at the same time.

[0085] At each peak of uterine contraction, the electroencephalogram signal detection module 300 collects the maternal electroencephalogram signals in real time and transmits the data to the information processing unit 500. These signals reflect the active state of the maternal brain, especially in terms of pain perception and emotional changes. The information processing unit 500 pre-processes the received electroencephalogram signals, including filtering, denoising, etc., to remove interference signals and ensure data accuracy. The information processing unit 500 analyzes the characteristics of the electroencephalogram signals to assess the maternal pain state. The specific analysis of the information processing unit 500 to assess the maternal pain state includes: calculating the frequency of the electroencephalogram, judging whether there is a specific frequency band related to pain (such as the increase of β wave or γ wave); evaluating the energy distribution of different frequency bands to judge whether there is a high frequency component related to pain; calculating the average amplitude, variance, slope, etc. of the electroencephalogram, to evaluate the trend of brain activity. The information processing unit 500 preferably can also extract time domain and frequency domain features from the electroencephalogram signals to assess the maternal stress state. The specific features extracted by the information processing unit 500 include: 1. Time domain features: calculate the average voltage level of the electroencephalogram signal, reflecting the overall intensity of brain activity; evaluate the volatility of the electroencephalogram signal, a larger variance indicating a higher active state of the brain; measure the rising or falling rate of the electroencephalogram signal, a larger slope indicating a rapid response of the brain to stimulation; record the time point at which the electroencephalogram signal reaches the maximum value, helping to identify the peak period of brain activity. 2. Frequency domain features: convert the electroencephalogram signal to the frequency domain and analyze the energy distribution of different frequency components. Common electroencephalogram frequency bands include δ wave (0.5-4 Hz), θ wave (4-8 Hz), α wave (8-12 Hz), β wave (12-30 Hz) and γ wave (30-100 Hz). In particular, the increase of β wave and γ wave is usually related to high stress state; calculate the energy density of each frequency band to evaluate the relative contribution of different frequency components, a higher power spectral density indicating a stronger energy in that frequency band, which is related to the anxiety or pain perception of the maternal; calculate the absolute power or proportion relative to the total power of each frequency band to help quantify the importance of different frequency bands; measure the width of the frequency spectrum to evaluate the complexity of the electroencephalogram signal, a wider frequency spectrum bandwidth indicating a more complex activity state of the brain.

[0086] Further, the information processing unit 500 constructs a comprehensive stress index (Stress Index, SI) according to the extracted time domain and frequency domain features. This index is used to quantify the current stress level of the maternal, and the specific calculation method of the stress index SI is as follows:

[0087] SI = w1 × average amplitude + w2 × variance + w3 × β wave power + w4 × γ wave power

[0088] wherein w1, w2, w3, w4 are weight coefficients, in the present embodiment, these weight coefficients are obtained based on clinical experience and literature review, or based on statistical analysis of experimental data. These weight coefficients are preferably optimized according to clinical experience and experimental data.

[0089] The information processing unit 500 compares the SI with a preset threshold value to determine the stress state of the parturient. When the SI exceeds the threshold value, it indicates that the parturient is in a high stress state; otherwise, when the SI is lower than the threshold value, it indicates that the stress state of the parturient is relatively stable. Based on the analysis result of the brain wave signal, the information processing unit 500 dynamically adjusts the drug injection amount. If the brain wave signal shows that the parturient is in a high stress state, the information processing unit 500 controls the analgesic drug delivery device 100 to increase the drug dose; if the brain wave signal shows that the stress state of the parturient is relatively stable, the information processing unit 500 controls the analgesic drug delivery device 100 to maintain the current dose or appropriately reduce the dose.

[0090] According to a preferred embodiment, the information processing unit 500 dynamically adjusts the drug injection amount according to the stress state index SI of the parturient.

[0091] Specifically, the information processing unit 500 is configured to control the analgesic drug delivery device 100 to maintain the current drug dose when the SI is lower than the threshold value, to avoid overuse of drugs. At this time, the system appropriately reduces the drug injection amount to prevent side effects caused by drug accumulation.

[0092] Specifically, the information processing unit 500 is configured to control the analgesic drug delivery device 100 to increase the drug dose when the threshold value ≤ SI < high threshold value, to relieve the pain and discomfort of the parturient. In the present embodiment, the specific increase is linearly or non-linearly adjusted according to the specific value of SI.

[0093] Specifically, the information processing unit 500 is configured to control the analgesic drug delivery device 100 to significantly increase the drug dose when SI ≥ high threshold value, to quickly relieve the high stress state of the parturient. At this time, the system will preferentially use more potent analgesic drugs (such as sufentanil), and if necessary, combined with other auxiliary drugs (such as ropivacaine).

[0094] In this embodiment, when the parturient feels an increase in pain, a request signal can be sent through the patient request unit 210 on the handgrip 200. The patient request unit 210 includes a vibration sensor 211 that can recognize the parturient's tapping behavior. After receiving the request signal, the information processing unit 500 re-evaluates the parturient's pain state in combination with the current contraction rhythm and the brain wave signal, and generates a new drug injection instruction. If the parturient's pain state requires additional analgesic drugs, the patient request unit 210 will appropriately increase the drug dose within the pre-set safety range. To avoid excessive drug use, the patient request unit 210 will set a minimum interval time (e.g., 5 minutes) after each manual request to prevent excessive drug use caused by frequent requests.

[0095] The information processing unit 500 further optimizes the adjustment of the drug injection amount in combination with the contraction rhythm data collected by the contraction detection module 400. The specific cooperative adjustment mode of the information processing unit 500 is as follows: at the peak period of each contraction, the drug injection amount is increased according to the parturient's stress state index (SI) and contraction intensity to ensure that the parturient obtains sufficient analgesic effect when it is most needed; during the contraction interval, the drug injection amount is reduced or even suspended to avoid side effects caused by drug accumulation; as the contraction frequency increases, the baseline level of the drug injection amount is gradually increased to adapt to the parturient's gradually increasing pain demand. For example, when the contraction frequency increases from once every 10 minutes to once every 5 minutes, the system will correspondingly increase the increase amplitude of the drug injection amount.

[0096] In this embodiment, as the number of contractions increases, the information processing unit 500 gradually adjusts the drug injection amount according to the changes in contraction rhythm. The specific adjustment mode of the information processing unit 500 is as follows: at the first contraction peak period, 5 μg of sufentanil is injected as the first dose of drug; at the subsequent contraction peak periods, 0.3 μg / mL of sufentanil + 0.1% ropivacaine mixed drug is injected at each contraction peak period, and the injection amount is gradually increased by a pre-set increase value (e.g., 0.5 mL each time) as the number of contractions increases; maximum injection amount limit: to ensure safety, the information processing unit 500 sets a total injection amount of no more than 5 mL within every 20-30 minutes. During the contraction interval, the information processing unit 500 will reduce the drug injection amount to avoid side effects caused by drug accumulation. For example, during the contraction interval, the information processing unit 500 will suspend drug injection or only maintain a low dose of background infusion.

[0097] The emotional information collection unit 230 on the handgrip 200 includes a voice recognizer 231 and a player 232, which are used to collect the voice of the parturient woman and provide emotional support. When the parturient woman shows signs of anxiety or fear, the system will play soothing music or voice prompts through the player 232 to help the parturient woman relax and reduce psychological stress. If the voice decibel of the parturient woman exceeds the preset threshold (such as 80 dB) and lasts for a long time, the system will issue an alarm to remind medical staff to pay attention to the emotional state of the parturient woman and provide additional support as needed.

[0098] The system monitors the vital signs of the parturient woman (such as heart rate, blood pressure, blood oxygen, etc.) in real time, and combines the data with the data from the uterine contraction detection module 400 and the electroencephalogram signal detection module 300 to comprehensively assess the health status of the parturient woman. When the system detects any abnormal conditions (such as abnormal fetal heart rate, excessively high or low blood pressure of the parturient woman, etc.), it will immediately stop drug injection and issue an alarm to notify medical staff. Medical staff can take necessary intervention measures in a timely manner according to the system's prompts to ensure the safety of the mother and baby.

[0099] The information processing unit 500 records data such as the time node of each uterine contraction, the amount of drug injection, the electroencephalogram signal, and the emotional information, and stores them in the system. The system automatically learns and optimizes the analgesic regimen based on historical data to ensure that the analgesic effect is more accurate and effective each time. Medical staff can view the reports generated by the system at any time to understand the analgesic effect and physiological response of the parturient woman, so as to make more reasonable treatment decisions. For example, during drug delivery, if the parturient woman feels pain again and sends a new request signal, the information processing unit 500 will re-evaluate the stress state and uterine contraction signal of the parturient woman and make a second adjustment to the amount of drug delivery.

[0100] The present embodiment also provides an analgesic method. In the present embodiment, the CPU is integrated on the analgesic drug delivery device 100 as an example, as shown in FIG. 4. Except that the control method of the information processing unit 500 on the analgesic drug delivery device 100 is different, the other hardware is the same as the previous embodiment.

[0101] Another aspect of the present application relates to a physiological parameter detection module 600. The physiological parameter detection module 600 includes a blood oxygen detection unit, a blood pressure detection unit, and / or a heart rate detection unit. The physiological parameter detection module 600 also includes a power supply unit for powering the above-mentioned detection units.

[0102] The physiological parameter detection module 600 can be configured as a smart bracelet worn on the wrist of the parturient woman. The physiological parameter detection module 600 can replace the ring 252 provided at one end of the rebound wrist rope 250 in the handgrip 200.

[0103] The handgrip 200 is provided with an emotion information collection unit 230 comprising a voice recognizer 231 and a player 232. The emotion information collection unit 230 is capable of collecting the voice of the parturient. When the physiological parameters (e.g. blood pressure, blood oxygen, heart rate) of the parturient are out of the range of normal parturient signs, the information processing unit 500 controls the analgesic drug delivery device 100 to stop delivering analgesic drug to the parturient, and issues a voice prompt through the emotion information collection unit 230. When the medical staff confirms that the physiological parameters of the parturient have no influence, based on the secondary confirmation of the medical staff through his handheld device or other means (i.e. sending a signal of secondary confirmation to the information processing unit 500 through his handheld device or other means), the information processing unit 500 controls the analgesic drug delivery device 100 to resume work, and continues the above-mentioned drug delivery method after resuming the historical data. The historical data includes all data generated by the parturient during this production before the analgesic drug delivery device 100 stops delivering analgesic drug to the parturient. For example: when the second regular uterine contraction is in the intermittent period, the blood oxygen of the parturient is lower than the preset threshold, the information processing unit 500 controls the analgesic drug delivery device 100 to stop delivering analgesic drug to the parturient, and based on the voice collected by the voice recognizer 231 of the emotion information collection unit 230 exceeding the preset decibel for more than a preset time, the information processing unit 500 issues a prompt to the medical staff through the player 232, which contains the voice information of the parturient's blood oxygen and the parturient's voice exceeding the preset decibel for more than a preset time. After the medical staff sends a signal of secondary confirmation through the button 251 provided on the analgesic drug delivery device 100, the information processing unit 500 acquires the signal collected by the uterine contraction detection module 400 which has not stopped collecting before, and controls the analgesic drug delivery device 100 to provide analgesic drug for the parturient according to the current uterine contraction state of the parturient.

[0104] It should be noted that the above-mentioned specific embodiments are exemplary, and those skilled in the art can think of various solutions under the inspiration of the disclosure of the present application, and these solutions also belong to the disclosed range of the present application and fall within the protection scope of the present application. Those skilled in the art should understand that the specification and drawings of the present application are illustrative and not constitute a limitation on the claims. The protection scope of the present application is defined by the claims and their equivalents. The specification of the present application contains multiple inventive concepts, such as "preferably", "according to a preferred embodiment" or "specifically", which all indicate that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to file a divisional application according to each inventive concept. Throughout the text, the features introduced by "preferably" are only optional ways, and should not be understood as necessarily provided, therefore the applicant reserves the right to abandon or delete the relevant preferred features at any time.

Claims

1. A pain relief administration system for labor process, comprising: a pain relief drug delivery device (100) for administering pain relief drugs to a parturient during uterine contraction process, characterized in that, the system further comprises: an electroencephalogram signal detection module (300) for collecting electroencephalogram signals representing brain activity characteristics of the brain; a uterine contraction detection module (400) for acquiring uterine fluctuation state signals during uterine contraction, and an information processing unit (500) connected to the pain relief drug delivery device (100), the electroencephalogram signal detection module (300), and the uterine contraction detection module (400) respectively, wherein the information processing unit (500) is configured to control the pain relief drug delivery device (100) to adjust the type and amount of drugs during the process of the parturient producing labor pain to reduce the parturient's pain according to the uterine contraction state reflected by the signals collected by the uterine contraction detection module (400) and the parturient stress state information reflected by the signals collected by the electroencephalogram signal detection module (300).

2. The analgesic dosing system of claim 1, wherein, The uterine contraction detection module (400) is used to collect characteristics conforming to the peak period of uterine contraction, and the information processing unit (500) is driven by the generation time node of the regular waveform curve conforming to the characteristics of the peak period of uterine contraction to control the type and amount of drugs administered by the pain relief drug delivery device (100) during the process of the parturient producing labor pain.

3. The analgesic administration system according to claim 1 or 2, characterized in that The information processing unit (500) is configured to control the injection amount of the pain relief drug delivery device (100) to increase by a preset amount each time a regular waveform curve conforming to the characteristics of the peak period of uterine contraction is generated.

4. The analgesic administration system according to claim 1 or 2, characterized in that The pain relief drug delivery device (100) comprises a first drug liquid box (120) and a second drug liquid box (130) driven by driven modules (110) respectively placed for different types of drugs.

5. The analgesic dosing system of claim 1, wherein, The uterine contraction detection module (400) comprises a potential signal acquisition unit (410), wherein the potential signal acquisition unit (410) acquires the original bioelectric potential signal of the parturient on the abdomen of the parturient to obtain the uterine contraction state of the parturient.

6. The analgesic administration system of claim 3, wherein, The information processing unit (500) is configured to generate an initial drug injection amount matched with the brain information presented by the electroencephalogram signal detection module (300), and dynamically adjust the initial drug injection amount according to the original bioelectric potential signal presented by the uterine contraction detection module (400).

7. The analgesic administration system of claim 6, wherein, The system further comprises a handgrip (200) capable of sending a request signal to the pain relief drug delivery device (100), wherein the sending of the request signal is realized by a patient request unit (210) comprising a vibration sensor (211) in the handgrip (200).

8. The analgesic administration system of claim 7, wherein, The handgrip (200) further comprises an elastic shell (240) and a pressure assembly (220) for adjusting the expansion degree of the elastic shell (240), the pressure assembly (220) is in signal connection with an information processing unit (500), during the process of the increase of the contraction degree of the puerpera, the information processing unit (500) controls the elastic deformation of the pressure assembly (220) to make the handgrip (200) match the grip of the puerpera.

9. The analgesic administration system of claim 8, wherein, The pressure assembly (220) comprises at least two elastic support rods (221) and a pressure sensor (223) arranged at the intersection center of the elastic support rods (221) and capable of sensing the pressure value of the corresponding elastic support rod (221), wherein when the pressure value transmitted by the pressure sensor (223) exceeds the preset threshold value, the spring compressor (222) arranged at one end of the elastic support rod (221) for adjusting the spring compression range of the elastic support rod (221) is controlled by the information processing unit (500) to decompress the spring, so as to adjust the expansion degree of the elastic shell of the handgrip (200).

10. The analgesic administration system of claim 7, wherein, The patient request unit (210) is a component of a tapping signal sending mode.

11. The analgesic administration system of claim 8, wherein, The surface of the elastic shell (240) is provided with at least one finger sleeve (260), wherein the area corresponding to the at least one finger sleeve (260) is provided with a vibration sensor (211) capable of sensing the tapping behavior generated by the corresponding area.

12. The analgesic administration system of claim 8, wherein, The surface of the elastic shell (240) is provided with a rebound wrist connecting rope (250) to enable the suspended handgrip (200) to rebound to the hand of the puerpera and re-recover the control of the analgesic drug delivery device (100).

13. The analgesic administration system of claim 12, wherein, One end of the rebound wrist connecting rope (250) is provided with an adjusting unit comprising a spring and a locking assembly, and the other end is provided with a ring (252) sleeved on the wrist of the puerpera.

14. The analgesic dosing system of claim 1, wherein, The information processing unit (500) is configured to record the analgesic drug use dose of the analgesic drug delivery device (100) and send it to the hospital information system for checking whether the amount of recovered analgesic drug is correct.

15. An analgesic drug administration control system comprising a handgrip (200) provided with a patient request unit (210), an analgesic drug delivery device (100) connected with the handgrip (200) and capable of providing drug delivery to the patient when the patient request unit (210) comprising a vibration sensor (211) transmits a request signal, and an information processing unit (500) for generating a signal for controlling the injection amount of the analgesic drug delivered by the analgesic drug delivery device (100) based on the received information related to the patient, characterized in that, The system is further provided with a contraction detection module (400) for collecting the contraction of the puerpera and an electroencephalogram detection module (300) for collecting the pain state of the puerpera, wherein, Upon receiving the request signal sent by the patient request unit (210), the information processing unit (500) generates an initial drug injection amount corresponding to the brain information based on the brain information presented by the brain electrical signal detection module (300), wherein the drug injection amount adjusted based on the brain information is adjusted within a partition range matching the uterine contraction rhythm reflected by the raw bioelectric potential signal presented by the uterine contraction detection module (400).

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