All-solid corneal surgery system guided by ssoct monitoring

Abstract

An all-solid corneal surgery system guided by SSOCT monitoring, which system relates to the technical field of medical devices. The all-solid corneal surgery system guided by SSOCT monitoring combines a multi-wavelength medical laser system with SSOCT monitoring technology, such that real-time, high-resolution ocular images can be provided during surgery, and on the basis of the all-solid corneal surgery system, surgical operations can be performed more accurately, thereby avoiding errors and risks. By means of SSOCT monitoring, detailed information of ocular anatomical structures, including a plurality of parameters such as corneal morphology and thickness, can be acquired, such that personalized adjustments can be made to a surgical process on the basis of individual characteristics of a patient, thereby improving surgical outcomes and prognosis. By means of real-time monitoring of ocular conditions, the all-solid corneal surgery system guided by SSOCT monitoring can better control risks during the surgical process, and can enhance control over factors including ablation depth and corneal structural stability, thereby minimizing surgical risks to the greatest extent possible.

Description

All-solid corneal surgery system under SSOCT monitoring guidance

[0001] Cross Reference to Related Applications

[0002] The present application claims priority to the Chinese patent application No. 202410625038.1, filed on May 20, 2024, and entitled "All-solid corneal surgery system under SSOCT monitoring guidance", the whole content of which is incorporated herein by reference. TECHNICAL FIELD

[0003] Embodiments of the present application relate to the technical field of medical equipment, and in particular to an all-solid corneal surgery system under SSOCT monitoring guidance BACKGROUND

[0004] According to the data of the World Health Organization (WHO), 1 billion people worldwide had vision impairment that could have been prevented or addressed in 2020, including 65.2 million cataracts and 69 million glaucoma, etc. The prevention and treatment rate needs to be improved. Among the causes of blindness, cataract accounts for 9%, and glaucoma accounts for 10%, both of which are the main causes of blindness and visual impairment in the world. The number of ophthalmic beds in ophthalmic hospitals and health institutions in China has been increasing continuously, which directly promotes the demand for the procurement of ophthalmic microscopes. Compared with foreign ophthalmic microscope products, domestic products have obvious price advantages, which is conducive to reducing the operating costs of hospitals and the medical costs of patients. However, in the field of high-end products, domestic products have a great competitive disadvantage in reputation and quality.

[0005] In the prior art, the eye is usually treated or diagnosed using individual instruments, which are designed to match the respective application purpose. For example, if a refractive error is to be corrected by means of a laser surgical procedure on the cornea, first an instrument is used which is suitable for diagnosing the eye, such as a slit lamp, an optical arrangement for three-dimensional measurement of the cornea, an arrangement for optical coherence tomography, etc. The results achieved using this diagnostic instrument are subsequently used to determine the measures for the treatment, to select and prepare the instruments available for the treatment. During the treatment, a so-called "Flapschneide" laser (also known as a laser keratome, or in its mechanical variant as a microkeratome) is first used to produce a flap-like cover (Deckel), which is referred to as a "flap", on the surface of the cornea before the refractive error is corrected. This flap-like cover is significantly thinner than the cornea. In order to be able to produce this flap-like cover as precisely as possible, a laser keratome is used in the prior art, which produces a treatment laser beam with a pulse width of less than 10-12 s. By this, a locally limited breakthrough with an extension of only a few micrometers is achieved in the cornea. By purposefully arranging a plurality of such breakthroughs next to one another, the desired "flap" can be produced and made reversible. After the "flap" has been produced, another instrument is used to cut tissue from the exposed inner area of the cornea in the reversed "flap" for the purpose of correcting the refractive error. The cutting operation in turn requires the introduction of energy by means of a pulsed treatment laser beam, which can come from an excimer laser. After the treatment, the use of a diagnostic instrument is usually also required in order to be able to evaluate the treatment result and, if necessary, to be able to schedule a follow-up treatment.

[0006] It can thus be seen that during the treatment, the sequence of the instruments used for diagnosing or treating the eye must be carefully considered, wherein in particular the patient-related identification data, the diagnostic data and / or the treatment data and the treatment-related configuration data or protocol data and control signals are considered, so that the physician or user who carries out the treatment can make the necessary adjustments on the respective instruments used for the treatment or diagnosis. The patient also needs to be repositioned because of the different instruments, or the individual instruments need to be moved in order to be aligned with the eye of the patient to be diagnosed or treated.

[0007] In the prior art, the patient is transported from one instrument to the next instrument during the treatment, since the instruments used are usually separate from one another. However, this alone does not guarantee the precise positioning necessary for the treatment or diagnosis on the respective instrument. Since the geometrical dimensions of the instruments do not match one another, not only does the patient need to be transported between the instruments, but also the position of the patient needs to be adjusted according to the respective instrument design. SUMMARY

[0008] Swept-Source Optical Coherence Tomography (SSOCT) is a non-contact imaging mode that can detect backscattered photons from tissue with high sensitivity and micron-scale spatial resolution. The advent of Fourier-domain detection of SSOCT and its confirmation of sensitivity advantage over time-domain technology has facilitated the transition from real-time two-dimensional B-SCAN imaging to real-time three-dimensional volumetric imaging.

[0009] Based on this, the embodiment of the present application proposes a full solid corneal surgery system under SSOCT monitoring guidance to realize the whole process of full solid corneal surgery through an integrated surgical system under SSOCT monitoring guidance.

[0010] The first aspect of the embodiment of the present application provides a full solid corneal surgery system under SSOCT monitoring guidance, comprising: an SSOCT system and a multi-wavelength medical laser system, the multi-wavelength medical laser system comprising a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first mirror, a second laser transmission device, a positioning laser device eye tracking system, and a surgical microscope, the deep ultraviolet nanometer laser generates laser with a wavelength of 190 nanometers to 213 nanometers, the femtosecond laser generates laser with a wavelength of 800 nanometers to 1100 nanometers, the laser with a wavelength of 190 nanometers to 213 nanometers is transmitted to the first mirror through the first laser transmission device, and the laser with a wavelength of 800 nanometers to 1100 nanometers is transmitted to the first mirror through the large digital aperture focusing lens group; the laser passing through the first mirror is transmitted to the target position through the second laser transmission device, and the positioning laser device adjusts the position of the laser based on the eye tracking system and the surgical microscope; the laser with a wavelength of 190 nanometers to 213 nanometers is used for cutting processing of the cornea; and the laser with a wavelength of 800 nanometers to 1100 nanometers is used for cutting in the middle layer of the cornea.

[0011] The SSOCT system acquires real-time eye images, outputs a control signal based on the real-time eye images, and controls the working parameters of each component in the multi-wavelength medical laser system.

[0012] Optionally, the deep ultraviolet nanometer laser generates laser with a wavelength of 213 nanometers, the femtosecond laser generates laser with a wavelength of 1053 nanometers, the first mirror reflects the 1053 nanometer laser and transmits the 213 nanometer laser in the first state, and the first mirror reflects the 213 nanometer laser and transmits the 1053 nanometer laser in the second state.

[0013] The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls related parameters of each component in the multi-wavelength medical laser system, including:

[0014] The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls the state of the first mirror, the working parameters of the femtosecond laser, and the working parameters of the deep ultraviolet nanosecond laser.

[0015] Optionally, the femtosecond laser is a high-repetition-frequency femtosecond laser between 800 nanometers and 1100 nanometers.

[0016] Optionally, the deep ultraviolet laser is a 213 nanometer pulse laser of a Nd:YAG five times frequency, and the frequency of the solid laser is converted to generate a deep ultraviolet pulse laser with a wavelength between 190 nanometers and 213 nanometers.

[0017] Optionally, the first laser transmission device comprises a beam compensator, a mirror, a beam expander, and a beam homogenizer.

[0018] Optionally, the second laser transmission device comprises an X-Y scanning mirror and a focusing lens.

[0019] Optionally, the femtosecond laser is a fiber laser, the pulse energy is 1 muJ, the pulse width is 300 fs, the pulse frequency is less than 4 MHz, and the cooling mode is air cooling.

[0020] Optionally, the fiber laser generates laser with a spot diameter of 3 mu m and a focusing energy of 150 nJ / pulse, and the focusing range is 300 mu m.

[0021] The all-solid corneal surgery system under the guidance of the SSOCT monitoring provided in the embodiment of the application combines the all-solid corneal surgery system with the SSOCT monitoring technology, can provide a real-time and high-resolution eye image during the surgery process, and can perform the surgery operation more accurately based on the system to avoid errors and risks. In the embodiment of the application, detailed eye anatomical structure information, including corneal morphology, thickness, and multiple parameters, can be acquired through the SSOCT monitoring, so that the surgery process can be individually adjusted according to the individual characteristics of the patient to improve the surgery effect and prognosis. The all-solid corneal surgery system under the guidance of the SSOCT monitoring can better control the risks in the surgery process through real-time monitoring of the eye condition, including control of the cutting depth and the stability of the corneal structure, so as to minimize the surgery risks.

[0022] The SSOCT monitoring guided all-solid corneal surgery system provided by the embodiment of the application, the multi-wavelength medical laser system can control the state conversion of the first reflector under the SSOCT monitoring guidance, the 1053nm laser is reflected by the first reflector, the 213nm laser is transmitted by the first reflector, or the 213nm is reflected by the first reflector and the 1053nm is transmitted, so that one instrument can be used to realize that the 213nm laser can be used for precise cutting treatment of the cornea and the 1053nm laser can be used for cutting in the middle layer of the cornea, so that the treatment process is simplified, the treatment efficiency is improved, and the patient is not transferred. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments of the present application will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0024] Fig. 1 shows a structure schematic diagram of a SSOCT monitoring guided all-solid corneal surgery system provided by the embodiment of the application;

[0025] Fig. 2 shows a structure schematic diagram of a multi-wavelength medical laser system in a SSOCT monitoring guided all-solid corneal surgery system provided by the embodiment of the application. DETAILED DESCRIPTION

[0026] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the present application will be further described in detail below with reference to the drawings and specific embodiments.

[0027] In the embodiment of the present application, a full solid corneal surgery system under SSOCT monitoring guidance is provided, as shown in Figure 1, which shows a structural schematic diagram of the full solid corneal surgery system under SSOCT monitoring guidance provided by the embodiment of the present application. Specifically, the system comprises an SSOCT system and a multi-wavelength medical laser system. In the embodiment of the present application, a structural schematic diagram of the multi-wavelength medical laser system in the full solid corneal surgery system under SSOCT monitoring guidance is also provided, as shown in Figure 2. Specifically, the multi-wavelength medical laser system comprises a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first mirror, a second laser transmission device, a positioning laser device eye tracking system, and a surgical microscope. The deep ultraviolet nanometer laser generates laser with a wavelength of 190-213 nm. The femtosecond laser generates laser with a wavelength of 800-1100 nm. The laser with a wavelength of 190-213 nm is transmitted to the first mirror through the first laser transmission device. The laser with a wavelength of 800-1100 nm is transmitted to the first mirror through the large digital aperture focusing lens group. The laser passing through the first mirror is transmitted to the target position through the second laser transmission device. The positioning laser device adjusts the position of the laser based on the eye tracking system and the surgical microscope. The laser with a wavelength of 190-213 nm is used for cutting processing of the cornea. The laser with a wavelength of 800-1100 nm is used for cutting in the middle layer of the cornea.

[0028] The SSOCT system acquires real-time eye images, outputs control signals based on the real-time eye images, and controls the working parameters of each component in the multi-wavelength medical laser system.

[0029] In the embodiment of the present application, SSOCT is a non-invasive imaging technology for imaging eye structures. It uses a laser light source to emit a beam of near-infrared light and generates high-resolution eye images by measuring the reflection of the light beam. SSOCT can provide detailed information about eye structures such as the retina, vitreous body, optic nerve, and cornea. The SSOCT system uses a swept source to provide faster imaging speed and higher resolution. The SSOCT system uses a swept source to emit a series of wave packets, thereby achieving higher speed and resolution.

[0030] In specific applications, the SSOCT system can provide real-time eye images to help doctors accurately locate the surgical area and structure, and perform precise surgical planning and operation. Based on the real-time eye images, control signals can be output to control the working parameters of each component in the multi-wavelength medical laser system.

[0031] In the embodiment of the present application, the SSOCT system avoids additional damage to the eye tissue while imaging at high speed. Specifically, SSOCT is a non-invasive imaging technique that uses optical principles for imaging without the need for direct contact with the eyeball or eye tissue. This means that during surgery, the SSOCT system does not directly cause physical damage to the eye tissue. In addition, the SSOCT system uses a swept source technology, which can provide faster imaging speed. This means that the image acquisition time is very short, reducing the exposure time of the eye tissue and thus reducing the risk of additional damage. In addition, the SSOCT system has the advantage of high resolution, which can provide clear and detailed high-resolution imaging of the eye. This allows doctors to more accurately observe the eye structure and avoid misoperation or unnecessary damage to the surrounding tissue. Thus, the SSOCT system can accurately guide the multi-wavelength medical laser system to perform cutting on the cornea and in the middle layer of the cornea by non-invasive imaging, fast imaging and high-resolution imaging while imaging at high speed to avoid additional damage to the eye tissue.

[0032] In the embodiment of the present application, the SSOCT system can also provide real-time eye images, and doctors can observe the eye structure through the monitor screen during surgery. This allows doctors to accurately locate the surgical area and structure and make timely adjustments. Specifically, the high-resolution imaging of the SSOCT system can clearly display the eye anatomical structure, including the retina, vitreous body, optic nerve and cornea. Doctors can understand the state and position of the eye tissue according to these image information, thereby guiding the surgical operation. The SSOCT system also has a guide marker and measurement function, and doctors can mark and measure on the image to help determine the surgical position and angle. These markers and measurements can provide quantitative references to make the surgical operation more accurate.

[0033] In the embodiment of the present application, the SSOCT system can reconstruct three-dimensional images of the eye structure, and doctors can obtain a more comprehensive view by rotating and zooming in on the images. This helps doctors better understand the spatial relationship of the eye structure and perform more accurate surgical planning and operation.

[0034] In the embodiment of the present application, the femtosecond laser can be a high-repetition-rate femtosecond laser with a wavelength of 800-1100 nm.

[0035] In the embodiment of the present application, the deep ultraviolet laser is a Nd:YAG five times frequency 213 nm pulsed laser, which can generate deep ultraviolet pulsed laser with a wavelength of 190-213 nm by frequency conversion technology.

[0036] In actual application, either the 213 nm laser or the deep ultraviolet nanometer laser can be selected.

[0037] In actual application, the first mirror has two states, in the first state, the 213nm laser can be transmitted to the second laser transmission device, and in the second state, the 1053nm femtosecond laser can be transmitted to the second laser transmission device.

[0038] Optionally, in the first state of the first mirror, the 1053nm laser can be reflected, and the 213nm laser can be transmitted, and in the second state of the first mirror, the 213nm laser can be reflected, and the 1053nm laser can be transmitted.

[0039] In this case, in actual application, the first mirror can be set to the second state by default, so that even if one or more of the two lasers are started, the laser will not reach the eyeball position, and misoperation can be avoided. During the operation of the surgery, the femtosecond laser can be started first, the first mirror can be set to the second state, so that the 1053nm femtosecond laser generated by the femtosecond laser is reflected by the first mirror to reach the eyeball position, and precise cutting in the intermediate layer of the cornea is completed under the monitoring and guidance of the SSOCT. After the cutting of the intermediate layer of the cornea is determined to be completed under the monitoring and guidance of the SSOCT, a control signal is output to control the state of the first mirror, and the deep ultraviolet nanometer laser is started, so that the 213nm laser generated by the deep ultraviolet nanometer laser is transmitted through the first mirror to reach the eyeball position, and the cornea is cut and processed.

[0040] In the embodiment of the application, the eyeball tracking system can monitor the position and movement of the eyeball in real time to ensure that the laser is irradiated at the correct position. The eyeball tracking system can further help to reduce errors in surgery and improve the accuracy and safety of surgery.

[0041] Optionally, the first state of the first mirror can be to transmit the 213nm laser, and the second state can be to reflect the 1053nm laser.

[0042] In this case, in actual application, the femtosecond laser can be controlled to start first, and the first mirror can be controlled to adjust to the reflection function, so that the laser beam generated by the femtosecond laser is reflected into the second laser transmission device through the first mirror, and finally transmitted to the eyeball for cutting in the intermediate layer of the cornea. Subsequently, the femtosecond laser is controlled to be turned off. The 213nm laser or the deep ultraviolet nanometer laser is controlled to be started, and the first mirror is controlled to adjust to the transmission function, so that the laser beam is transmitted into the second laser transmission device through the first mirror, and finally transmitted to the eyeball for cutting and processing the cornea.

[0043] Specifically, the first mirror can be a lens with two faces of different curvatures, so that one face reflects the received light beam and the other face transmits the received light beam. In practical applications, the two states of the first mirror can be switched by flipping and adjusting the angle of the first mirror.

[0044] Specifically, the first mirror can also be a lens system composed of multiple lenses. By adjusting the number, position and curvature of the lenses, the two states of the first mirror can be switched.

[0045] In the embodiments of the present application, the large numerical aperture focusing lens group functions to focus light beams onto very small points or areas. Such a lens group is usually composed of multiple lenses to achieve more complex optical functions.

[0046] Specifically, the functions of the large numerical aperture focusing lens group include:

[0047] High numerical aperture: Large numerical aperture means that the diameter of the lens is larger than its focal length, which means that it can receive a larger range of incident light rays. Such a design enables the focusing lens group to collect more light rays and handle larger incident angles, improving the light collection efficiency and the luminous flux of the lens system.

[0048] High resolution: The large numerical aperture focusing lens group can provide higher resolution, i.e. can focus light rays more clearly, so that the size of the focal point is smaller. This is very important for applications that require high precision imaging or high resolution, such as microscopes, laser engraving and optical sensors, etc.

[0049] Optical correction: The focusing lens group can correct optical aberrations by combining lenses of different curvatures and shapes. This includes spherical aberration, chromatic aberration and aberration, etc. By optimizing the design and combination of the lens group, better optical performance can be achieved, improving the imaging quality and the clarity of the focal point.

[0050] Beam shape adjustment: The large numerical aperture focusing lens group can also adjust the shape of the light beam by the shape and combination of the lenses. For example, by using aspherical lenses or non-uniform lens curvature, the shape of the light beam can be adjusted, such as converting a circular light beam into an elliptical light beam.

[0051] In the embodiments of the present application, the second laser transmission device includes an X-Y scanning mirror and a focusing lens.

[0052] In the embodiments of the present application, the femtosecond laser is a fiber laser, the pulse energy is 1 mu J, the pulse width is 300 fs, the pulse frequency is less than 4 MHz, and the cooling method is air cooling.

[0053] In the embodiment of the application, the laser spot diameter generated by the fiber laser is 3 microns, the focused energy is 150 nJ / pulse, and the focusing range is 300 microns.

[0054] In the embodiment of the application, the X-Y scanning mirror is a component commonly used in optical systems and laser technology. It is composed of two mutually perpendicular mirrors, one for the horizontal direction (X-axis) and the other for the vertical direction (Y-axis). By controlling the movement of these two mirrors, precise positioning and orientation of the laser beam can be achieved. The main function of the X-Y scanning mirror is to change the direction and position of the light beam. By controlling the angle and speed of the scanning mirror, the light beam can be scanned, focused, deflected, and positioned on a plane.

[0055] The focusing lens in the multi-wavelength medical laser system provided by the embodiment of the application can focus the light beam onto a smaller point or area. The focusing lens can change the propagation direction of the light beam and the intensity distribution of the light rays, making the light beam more concentrated and powerful.

[0056] Specifically, the focusing lens has the following functions:

[0057] Focusing: The focusing lens can focus parallel incident light beams onto a focal point. By changing the relative position of the lens and the light beam or adjusting the curvature of the lens, the focal length and the position of the focal point of the light beam can be controlled.

[0058] Light beam shape adjustment: The focusing lens can change the shape of the laser light beam, such as converting a circular light beam into an elliptical light beam.

[0059] Light beam adjustment: The focusing lens can adjust the diameter and divergence angle of the light beam. By changing the aperture and curvature of the lens, the degree of divergence or focusing of the light beam can be controlled.

[0060] Optical correction: The focusing lens can also be used to correct optical aberrations in the light beam. For example, a spherical lens can correct spherical aberration, so that the light beam maintains better quality and clarity of the focal point during focusing.

[0061] Specifically, in actual application, the working parameters of the large digital aperture focusing lens group, X-Y scanning mirror and focusing lens can be controlled based on the real-time eye image obtained by the SSOCT system to adjust the direction, position, diameter and divergence angle of the laser light beam reflected by the first mirror, so as to meet the needs of the operation.

[0062] In the embodiment of the application, the first laser transmission device comprises a beam compensator, a mirror, a beam expander and a beam homogenizer.

[0063] In the embodiment of the present application, the light beam compensator is a device for adjusting the focal point position of the laser beam inside the eye. Its function is to correct the errors caused by the corneal shape, diopter and other factors when the light beam is refracted in the eyeball, to ensure that the laser can accurately focus on the retina, so as to achieve precise and effective treatment effect. In the embodiment of the present application, the light beam compensator can adjust the direction and intensity of the light beam at any time during the treatment process to correct the specific conditions of the patient's eye, thereby improving the accuracy and safety of the operation. This technology can greatly reduce the risk of surgery and improve the success rate of surgery and the treatment experience of patients.

[0064] In the embodiment of the present application, the beam expander can adjust and limit the diameter and shape of the 213 nanometer laser beam. The beam expander plays a role in focusing and controlling the laser beam, so that it can accurately irradiate to the specific part of the patient's eye, thereby achieving precise treatment effect.

[0065] In the embodiment of the present application, the beam expander can ensure the focusing degree and accuracy of the laser beam, improve the safety and precision of the operation, and limit the diameter of the laser beam within a smaller range, so that it can accurately concentrate on the specific area of the eye, while also maximizing the protection of surrounding tissues from unnecessary damage. By reasonably adjusting and using the beam expander, the doctor can better control the intensity and focusing range of the laser, thereby effectively performing various ophthalmic surgical treatments.

[0066] In the embodiment of the present application, the beam expander can also help control the energy density of the laser, ensuring that the laser produces appropriate thermal effects in the ocular tissues to achieve the desired treatment effect.

[0067] In the embodiment of the present application, the beam expander is usually composed of high-quality optical elements, which can maintain the quality and stability of the laser beam.

[0068] In the embodiment of the present application, the beam homogenizer can adjust the intensity distribution of the laser beam, so that it can uniformly cover the entire target area when processing the patient's ocular tissues. This can ensure that the patient receives uniform laser energy, improving the accuracy and safety of the operation. The beam homogenizer is usually made of special optical design and materials to ensure that the laser beam can be effectively homogenized when passing through the device. In addition, the beam homogenizer can also help adjust the diameter and shape of the laser beam to meet different surgical needs.

[0069] In the embodiment of the present application, in the application process of the multi-wavelength medical laser system, the doctor can cooperate with the eye tracking system, observe under the surgical microscope, and combine with the SSOCT system to obtain real-time eye images, control the working parameters of the light beam compensator, beam expander and beam homogenizer, and adjust the shape, position, focusing degree and intensity of the laser beam to adapt to the needs of patients.

[0070] In the embodiment of the present application, the 213nm laser or deep ultraviolet laser generated by the 213nm laser or deep ultraviolet nanometer laser can be first adjusted based on the cooperation of the beam compensator, beam expander and beam homogenizer to obtain a laser beam suitable for the actual situation of the patient. The laser beam is transmitted through the first mirror, and then transmitted to the cornea of the eyeball through the X-Y scanning mirror and the focusing lens, so as to complete the corneal cutting.

[0071] In the embodiment of the present application, during the transmission of the 213nm laser beam, the related parameters of the X-Y scanning mirror and the focusing lens in the second laser transmission device are fixed, and the related parameters of the beam compensator, the mirror, the beam expander and the beam homogenizer in the first laser transmission device are adjusted to make the shape, position, focusing degree and intensity of the 213nm laser beam meet the actual needs.

[0072] The multi-wavelength medical laser system provided by the embodiment of the present application can reflect the laser generated by the femtosecond laser machine through the first mirror, and can also transmit the laser generated by the 213nm or deep ultraviolet nanometer laser. One instrument can not only use 213nm laser to cut the cornea, but also use femtosecond solid laser to cut the middle layer of the cornea. In the treatment process, multiple instruments do not need to be used, and the patient does not need to be transferred, so that the treatment process can be simplified and the treatment efficiency can be improved.

[0073] In the embodiment of the present application, the SSOCT system can not only obtain real-time eyeball images during the operation process, output control signals based on the real-time eyeball images, and control the working parameters of each component in the multi-wavelength medical laser system, but also provide detailed information of the eye anatomical structure in the preoperative evaluation stage to help the doctor to plan the operation and simulate the preoperative, and can be used for checking the operation results and monitoring the recovery of the patient after the operation.

[0074] In the embodiment of the present application, a control method of the full solid corneal surgery system under the monitoring and guidance of the SSOCT is also provided. Specifically, the method comprises:

[0075] Step 1: Start the SSOCT system to obtain real-time eyeball images, and output the working parameters of the femtosecond laser, the large numerical aperture focusing lens group and the second laser transmission device based on the real-time eyeball images;

[0076] Step 2: Control the femtosecond laser to start, and control the X-Y scanning mirror and the focusing lens in the large numerical aperture focusing lens group and the second laser transmission device to work according to the working parameters determined in step 1.

[0077] Step 3: Control the femtosecond laser to emit laser to cut in the middle layer of the cornea.

[0078] Step 4: controlling the femtosecond laser to be closed, controlling the deep ultraviolet nanosecond laser to be started, controlling the first mirror to be switched to work, and outputting the working parameters of the beam compensator, the mirror, the beam expander and the beam homogenizer in the first laser transmission device based on the real-time eyeball image.

[0079] Step 5: controlling the deep ultraviolet nanosecond laser to emit laser, and performing cutting treatment on the cornea.

[0080] The above is only the preferred embodiment of the present application, and is not used to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

[0081] The above description of aspects of the application is provided so that any person skilled in the art can make or use the application. Various modifications to these aspects will be apparent to those skilled in the art, and the general principles defined herein can be applied to other aspects without departing from the scope of the application. Thus, the present application is not intended to be limited to the aspects shown herein, but is to be accorded the widest scope consistent with the principles and novel features herein.

[0082] The above description has been given for the purpose of illustration and description. Furthermore, this description is not intended to limit embodiments of the application to forms disclosed herein. Although a number of example aspects and embodiments have been discussed above, those of skill in the art will recognize certain variations, modifications, changes, additions, and sub-combinations thereof.

Claims

1. A system for all-solid corneal surgery under SSOCT monitoring guidance, characterized by, Comprise: SSOCT system and multi-wavelength medical laser system, the multi-wavelength medical laser system includes femtosecond laser, large digital aperture focusing lens group, deep ultraviolet nanometer laser, beam compensator, first laser transmission device, first mirror, second laser transmission device, positioning laser device eyeball tracking system, surgical microscope, the deep ultraviolet nanometer laser generates laser with wavelength between 190 nanometers and 213 nanometers, the femtosecond laser generates laser with wavelength between 800 nanometers and 1100 nanometers, the laser between 190 nanometers and 213 nanometers is transmitted to the first mirror through the first laser transmission device, the laser between 800 nanometers and 1100 nanometers is transmitted to the first mirror through the large digital aperture focusing lens group;The laser passing through the first mirror is transmitted to the target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the eyeball tracking system and the surgical microscope;The laser between 190 nanometers and 213 nanometers is used for cutting processing on the cornea;The laser between 800 nanometers and 1100 nanometers is used for cutting in the middle layer of the cornea; The SSOCT system obtains real-time eyeball images, and outputs control signals based on the real-time eyeball images to control the working parameters of each component in the multi-wavelength medical laser system.

2. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 1, wherein, The deep ultraviolet nanometer laser generates laser with wavelength of 213 nanometers, the femtosecond laser generates laser with wavelength of 1053 nanometers, the first mirror reflects 1053 nanometer laser and transmits 213 nanometer laser in the first state, and the first mirror reflects 213 nanometer laser and transmits 1053 nanometer laser in the second state; The SSOCT system obtains real-time eyeball images, and outputs control signals based on the real-time eyeball images to control the related parameters of each component in the multi-wavelength medical laser system, including: The SSOCT system obtains real-time eyeball images, and outputs control signals based on the real-time eyeball images to control the state of the first mirror, the working parameters of the femtosecond laser and the working parameters of the deep ultraviolet nanometer laser.

3. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 1, wherein, The femtosecond laser is a high-repetition-frequency femtosecond laser with wavelength between 800 nanometers and 1100 nanometers.

4. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 1, wherein, The deep ultraviolet laser is a 213 nanometer pulse laser of Nd:YAG five times frequency, and the solid laser is frequency converted to generate deep ultraviolet pulse laser with wavelength between 190 nanometers and 213 nanometers.

5. The multi-wavelength medical laser system of claim 1, wherein, The first laser transmission device comprises a beam compensator, a mirror, a beam expander and a beam homogenizer.

6. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 1, wherein, The second laser transmission device comprises an X-Y scanning mirror and a focusing lens.

7. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 1, wherein, The femtosecond laser is a fiber laser with pulse energy of 1 μJ, pulse width of 300 fs and pulse frequency of less than 4 MHz, and the cooling mode is air cooling.

8. The SS-OCT monitoring-guided all-solid corneal surgery system according to claim 4, wherein, The laser generated by the fiber laser has a spot diameter of 3 μm, a focusing energy of 150 nJ / pulse and a focusing range of 300 μm.

Images