Fully-automatic chemiluminescence apparatus for multi-channel multiplexed poct

Abstract

A fully-automatic chemiluminescence apparatus (100) for multi-channel multiplexed POCT, comprising: a mounting frame (10); a reaction chamber assembly (30) for loading multiplexed test reagent strips (20), wherein each multiplexed test reagent strip (20) is used for testing at least two markers, and the multiplexed test reagent strip (20) comprises a liquid storage area (211) which comprises a common liquid area (2112) and a dedicated liquid area (2111); a multi-channel multiplexed test parallel pretreatment device (40) comprising at least two rows of magnetic rods (4331), wherein each row of magnetic rods (4331) comprises at least two magnetic rods (4331), and the at least two rows of magnetic rods (4331) are used for transferring magnetic nanoparticles in adjacent holes of the multiplexed test reagent strips (20) into the liquid storage area (211); a film breaking assembly (50) for breaking sealing films in the common liquid area (2112); and a PMT assembly (60), wherein the reaction chamber assembly (30) moves the multiplexed test reagent strips (20) to the PMT assembly (60), so that luminescence value measurement is performed on the test positions of the multiplexed test reagent strips (20). Multiplexed test is realized while multi-channel parallel treatment is realized, the analysis efficiency of the apparatus is ensured, and efficient test of multiple items under test is realized while the volume of the apparatus is controlled.

Description

Multi-channel multi-association POCT full-automatic chemiluminescence equipment TECHNICAL FIELD

[0001] The application belongs to the technical field of medical equipment, and particularly relates to a multi-channel multi-association POCT full-automatic chemiluminescence equipment. BACKGROUND

[0002] Chemiluminescence immunoassay technology, as a rapidly developed non-radioactive immunoassay technology, has become one of the important directions of immunological detection, and its principle is to directly determine the immune reaction by using a chemiluminescence signal. The chemiluminescence equipment using the chemiluminescence immunoassay technology has the advantages of high sensitivity, good repeatability, high accuracy, good specificity and wide linear range.

[0003] POCT (Point-Of-Care Testing) is a detection method of performing clinical detection on a sampling site immediately, omitting the complex processing procedures of sample detection in a laboratory, and then quickly obtaining a detection result, and has the characteristics of simple instrument programming, easy operation and rapid report result.

[0004] At present, the multi-channel multi-association POCT full-automatic chemiluminescence equipment is manufactured by applying the chemiluminescence immunoassay technology to the POCT product, and has the advantages of instant detection and rapid diagnosis result, and is rapidly and widely promoted in the in-vitro diagnosis industry.

[0005] The multi-channel multi-association POCT full-automatic chemiluminescence equipment generally comprises a reaction bin module and a multi-channel parallel pretreatment module, the reaction bin module loads a reagent strip in which various reagents are sealed, and moves the reagent strip to the multi-channel parallel pretreatment module for corresponding treatment, such as breaking the sealing film on the reagent hole, transferring magnetic particles and the like. The length of the reagent strip is affected by the number of detection items, and the reagent strip needs to be increased accordingly, and then the length of the reagent strip is also increased.

[0006] When the equipment is used for detection and analysis of multiple items, the distance that the reaction bin module needs to move with the reagent strip in the equipment will be increased, so as to move the reagent strip to the multi-channel parallel pretreatment module for corresponding treatment, such as breaking the sealing film on the reagent strip by moving a long distance, which will cause the volume of the equipment to increase, is not conducive to the miniaturization of the equipment, and will also prolong the detection and diagnosis result time.

[0007] And, the current multi-channel parallel pre-processing module can only transfer magnetic particles in one well of a reagent strip at a time, if magnetic particles in multiple wells need to be transferred, multiple operations are required, which increases the risk of cross interference, prolongs the transfer time of magnetic particles, and affects the analysis efficiency of the equipment. TECHNICAL PROBLEM

[0008] One of the purposes of the embodiments of the present application is to provide a multi-channel multi-association POCT full-automatic chemiluminescence equipment, aiming to solve the problems of how to control the size of the equipment and ensure the detection speed of the equipment when the reagent strip is increased to adapt to multiple detection requirements, and the existing multi-channel parallel pre-processing module needs multiple operations when transferring magnetic particles in multiple wells, which increases the risk of cross interference, prolongs the transfer time of magnetic particles, and affects the analysis efficiency of the equipment. TECHNICAL SOLUTION

[0009] The embodiments of the present application are implemented as follows: a multi-channel multi-association POCT full-automatic chemiluminescence equipment, comprising:

[0010] a mounting frame;

[0011] a reaction chamber assembly arranged on the mounting frame and used for loading a multi-association reagent strip, the reaction chamber assembly being movable back and forth along the length direction of the mounting frame, the multi-association reagent strip being used for detecting at least two markers, the multi-association reagent strip comprising a liquid storage area, the liquid storage area comprising a common liquid area and a special liquid area distributed along the length direction of the multi-association reagent strip;

[0012] a multi-channel multi-association parallel pre-processing device arranged on the mounting frame, the multi-channel multi-association parallel pre-processing device comprising at least two rows of magnetic rods arranged side by side along the movement direction of the reaction chamber assembly, each row of the magnetic rods comprising at least two magnetic rods, and the at least two rows of magnetic rods being used for transferring magnetic particles in adjacent wells of the multi-association reagent strip in the liquid storage area;

[0013] a membrane breaking assembly arranged on the mounting frame and located at the rear end of the multi-channel multi-association parallel pre-processing device, the membrane breaking assembly being used for breaking the sealing film of the common liquid area; and

[0014] a PMT assembly arranged on the mounting frame and located at the rear end of the membrane breaking assembly, the reaction chamber assembly being used for moving the multi-association reagent strip to the PMT assembly, and the PMT assembly being used for detecting the luminescence value of the detection site of the multi-association reagent strip.

[0015] Further, the multi-channel multi-association parallel pre-processing device comprises:

[0016] A gantry arranged on the bottom plate of the mounting frame, a top of the gantry is provided with a first driving element;

[0017] A sample extraction mechanism arranged on the gantry, the sample extraction mechanism is in transmission connection with the first driving element, and can be lifted and lowered under the driving of the first driving element to suck and spit the sample on the multi-union detection reagent strip; and

[0018] A sample pretreatment mechanism arranged on the gantry, the sample pretreatment mechanism is in transmission connection with the first driving element, and can be lifted and lowered under the driving of the first driving element, and at least two rows of the magnetic rods are arranged on the sample pretreatment mechanism.

[0019] Further, the sample pretreatment mechanism comprises:

[0020] A first mounting frame arranged on the gantry and in transmission connection with the first driving element, the first driving element can drive the first mounting frame to lift and lower;

[0021] A second driving element arranged on the first mounting frame; and

[0022] A pretreatment assembly arranged on the first mounting frame and in transmission connection with the second driving element, at least two rows of the magnetic rods are arranged on the pretreatment assembly and in transmission connection with the second driving element, and the second driving element can drive at least two rows of the magnetic rods to lift and lower to transfer magnetic particles.

[0023] Further, the pretreatment assembly comprises:

[0024] A magnetic rod device arranged on the first mounting frame, a plurality of movable through holes are formed in the magnetic rod device, a plurality of first loading heads for loading disposable magnetic separation sleeves are arranged on the bottom of the magnetic rod device, and the plurality of first loading heads are in one-to-one correspondence with the plurality of movable through holes and communicate with each other;

[0025] A first push plate arranged above the magnetic rod device, the first push plate is in transmission connection with the second driving element; and

[0026] A plurality of connecting rods arranged on the first push plate, at least two rows of the magnetic rods are arranged on the free ends of the plurality of connecting rods in one-to-one correspondence, and the second driving element can drive the first push plate to lift and lower the magnetic rods in the corresponding movable through holes to be spaced apart from or pass through the first loading heads.

[0027] Further, the magnetic rods are in multiple rows, and the multiple rows of the magnetic rods are uniformly distributed along the width direction of the first push plate;

[0028] A plurality of said magnetic rods are arranged in each row, and the plurality of said magnetic rods in each row are evenly distributed along the length direction of said first push plate.

[0029] Further, the sample extraction mechanism comprises:

[0030] A second mounting frame is arranged on said gantry and is in transmission connection with said first driving element, and said first driving element can drive said second mounting frame to ascend and descend;

[0031] A third driving element is arranged on said second mounting frame; and

[0032] An extraction assembly is arranged on said second mounting frame and is in transmission connection with said third driving element, and said third driving element can drive said extraction assembly to ascend and descend to suck and spit samples.

[0033] Further, the extraction assembly comprises:

[0034] An injection device is arranged on said second mounting frame, a plurality of injection cavities are formed in said injection device, a plurality of second loading heads for loading tip heads are arranged at the bottom of said injection device, and a plurality of said second loading heads are in one-to-one correspondence with a plurality of said injection cavities and are in communication therewith;

[0035] A second push plate is arranged above said injection device, and said second push plate is in transmission connection with said third driving element; and

[0036] A plurality of piston rods are arranged on said second push plate, said piston rods are in movable sealing connection with said injection cavities, and said third driving element can drive said second push plate to drive said piston rods to ascend and descend in said injection cavities to perform sucking and spitting actions.

[0037] Further, the sample extraction mechanism further comprises:

[0038] A push rod is movably arranged in said injection device, and the top end of said push rod is spaced from said second push plate;

[0039] An elastic element is sleeved on said push rod in said injection device, and said elastic element is simultaneously stretched or compressed when said push rod ascends and descends relative to said injection device; and

[0040] A separation plate is arranged at the bottom of said injection device, said second loading heads pass through said separation plate, the bottom end of said push rod is connected with said separation plate, and said push rod can drive said separation plate to ascend and descend relative to said second loading heads.

[0041] Further, the plurality of injector cavities are evenly distributed along a length direction of the injector device, the plurality of second loading heads are evenly distributed along the length direction of the injector device, and the plurality of piston rods are evenly distributed along a length direction of the second pushing plate.

[0042] Further, the sample extraction mechanism is opposite to the sample pretreatment mechanism, and the sample extraction mechanism is located in front of the sample pretreatment mechanism. The first driving element, the second driving element, and the third driving element are linearly arranged on the top of the gantry.

[0043] Further, the gantry is provided with a movable space, a transmission shaft of the first driving element passes through the movable space, and a transmission plate is sleeved on the transmission shaft. When the transmission shaft moves, the transmission plate can ascend and descend in the movable space.

[0044] The first mounting frame is provided with a first connecting portion on one side facing the gantry, and the second mounting frame is provided with a second connecting portion on one side facing the gantry. The first connecting portion and the second connecting portion are connected with the transmission plate.

[0045] Further, the first mounting frame is provided with a first sliding seat on one side facing the gantry, and the gantry is provided with a first sliding rail on one side facing the first mounting frame. The first sliding rail extends along the height direction of the gantry, and the first sliding seat is slidingly connected with the first sliding rail.

[0046] The second mounting frame is provided with a second sliding seat on one side facing the gantry, and the gantry is provided with a second sliding rail on one side facing the second mounting frame. The second sliding rail extends along the height direction of the gantry, and the second sliding seat is slidingly connected with the second sliding rail.

[0047] Further, one side of the top of the first mounting frame is provided with a first sensing element, and one side of the top of the gantry is provided with a first detector. The first sensing element can be inducted or disconnected with the first detector when the first mounting frame ascends and descends.

[0048] One side of the top of the second mounting frame is provided with a second sensing element, and one side of the top of the gantry is provided with a second detector. The second sensing element can be inducted or disconnected with the second detector when the second mounting frame ascends and descends.

[0049] Further, the reaction chamber assembly comprises:

[0050] A guide rail arranged on the bottom plate of the mounting frame.

[0051] A reaction chamber body is arranged on the guide rail, and a guide block is arranged on the bottom of the reaction chamber body and connected with the guide rail in a sliding mode. A plurality of accommodation grooves for loading the multi-connection detection reagent strips are arranged on the reaction chamber body in a uniform distribution mode, and the accommodation grooves extend along the length direction of the reaction chamber body.

[0052] A fourth driving element is arranged on the bottom plate of the mounting frame and located at the rear end of the guide rail, and a first driving pulley is arranged on the transmission shaft of the fourth driving element.

[0053] A mounting seat is arranged on the bottom plate of the mounting frame and located at the front end of the guide rail, and a first driven pulley is arranged on the mounting seat, and the first driving pulley is connected with the first driven pulley in a transmission mode through a belt.

[0054] A first synchronous belt pressing plate is arranged on one side of the reaction chamber body and connected with the belt.

[0055] Further, the PMT assembly comprises:

[0056] A mounting bracket is arranged on the bottom plate of the mounting frame.

[0057] A third mounting frame is arranged on the mounting bracket.

[0058] A fourth mounting frame is arranged on the bottom of the third mounting frame.

[0059] A PMT module is arranged on the fourth mounting frame.

[0060] A fifth driving element is arranged on the top of the third mounting frame and connected with the fourth mounting frame in a transmission mode, and the fifth driving element can drive the fourth mounting frame to lift and lower to drive the PMT module to lift and lower.

[0061] A sixth driving element and a second driven pulley are respectively arranged on the top of the two sides of the mounting bracket, a second driving pulley is arranged on the transmission shaft of the sixth driving element, and the second driving pulley is connected with the second driven pulley in a transmission mode through a belt.

[0062] A second synchronous belt pressing plate is arranged on the third mounting frame and connected with the belt.

[0063] Further, the membrane breaking assembly comprises:

[0064] A seventh driving element is arranged on the top of the mounting bracket.

[0065] A fifth mounting frame is arranged on the mounting bracket and located below the seventh driving element, the fifth mounting frame is connected with the seventh driving element in a transmission mode and can lift and lower under the driving of the seventh driving element.

[0066] a plurality of membrane breaking heads arranged at the bottom of the fifth mounting rack, the plurality of membrane breaking heads being evenly distributed along the length direction of the fifth mounting rack.

[0067] Further, the multi-association detection reagent strip comprises:

[0068] a reagent strip body, the liquid storage area being arranged on the reagent strip body;

[0069] a handle arranged at one end of the reagent strip body; and

[0070] a sample hole, a tip head, at least two disposable magnetic separation sleeves, the special liquid area and the common liquid area arranged in sequence from the handle to the other end of the reagent strip body on the reagent strip body;

[0071] the special liquid area comprising at least two kinds of magnetic micro-particle labeled ligands and at least two kinds of enzyme labeled ligands, and the common liquid area comprising a washing solution and a luminescent substrate solution.

[0072] In the embodiments of the present application, the multi-channel multi-association detection parallel pre-processing device comprises at least two rows of magnetic rods for transferring magnetic micro-particles, and each row of magnetic rods is at least two, that is, the multi-channel multi-association detection parallel pre-processing device can simultaneously transfer magnetic micro-particles in at least two adjacent reagent holes of a single multi-association detection reagent strip and transfer magnetic micro-particles in adjacent reagent holes of at least two parallelly arranged multi-association detection reagent strips, thereby realizing analysis and detection of at least two markers, achieving multi-channel parallel processing while realizing multi-association detection, reducing the risk of cross infection, shortening the time for transferring magnetic micro-particles, and ensuring the analysis efficiency of the equipment.

[0073] Moreover, on the basis of the structure of the equipment and in combination with the special design of the multi-association detection reagent strip, the operation of breaking the sealing film of the multi-association detection reagent strip does not need to be completely performed by the multi-channel multi-association detection parallel pre-processing device, but the sealing film of the common liquid area can be broken by the membrane breaking assembly at the rear end, the reaction chamber assembly does not need to move the multi-association detection reagent strip for a long distance to realize targeted membrane breaking, the repeated and long-distance movement of the reaction chamber assembly is reduced, the repeated membrane breaking work of the multi-channel multi-association detection parallel pre-processing device is reduced, the size of the multi-channel multi-association detection POCT full-automatic chemiluminescence equipment can be controlled, and efficient detection of multiple detection items can be realized. BRIEF DESCRIPTION OF DRAWINGS

[0074] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the embodiments or exemplary technical descriptions will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without any creative effort.

[0075] Fig. 1 is a perspective view of a multi-channel multi-association POCT full-automatic chemiluminescence equipment according to an embodiment of the present application;

[0076] Fig. 2 is another perspective view of a multi-channel multi-association POCT full-automatic chemiluminescence equipment according to an embodiment of the present application;

[0077] Fig. 3 is another perspective view of a multi-channel multi-association POCT full-automatic chemiluminescence equipment according to an embodiment of the present application;

[0078] Fig. 4 is a structural view of a multi-association reagent strip according to an embodiment of the present application;

[0079] Fig. 5 is a cross-sectional view of a multi-association reagent strip according to an embodiment of the present application;

[0080] Fig. 6 is a perspective view of a multi-channel multi-association parallel pre-treatment device according to an embodiment of the present application;

[0081] Fig. 7 is another perspective view of a multi-channel multi-association parallel pre-treatment device according to an embodiment of the present application;

[0082] Fig. 8 is a perspective exploded view of a multi-channel multi-association parallel pre-treatment device according to an embodiment of the present application;

[0083] Fig. 9 is a structural view of a multi-channel multi-association parallel pre-treatment device according to an embodiment of the present application;

[0084] Fig. 10 is a perspective view of a gantry according to an embodiment of the present application;

[0085] Fig. 11 is another perspective view of a gantry according to an embodiment of the present application;

[0086] Fig. 12 is a perspective view of a sample pre-treatment mechanism according to an embodiment of the present application;

[0087] Fig. 13 is a perspective view of a sample extraction mechanism according to an embodiment of the present application;

[0088] Fig. 14 is a perspective view of a reaction chamber main body according to an embodiment of the present application;

[0089] Fig. 15 is a perspective view of a membrane breaking assembly and a PMT assembly according to an embodiment of the present application;

[0090] Fig. 16 is a perspective view of a PMT assembly according to an embodiment of the present application.

[0091] In the drawings:

[0092] Multi-channel multi-association POCT full-automatic chemiluminescence equipment - 100;

[0093] Mounting frame - 10;

[0094] Multi-association inspection reagent strip-20;reagent strip main body-21;liquid storage area-211;special liquid area-2111;public liquid area-2112;handle-22;sample hole-23;tip head-24;disposable magnetic separation sleeve-25;

[0095] Reaction chamber assembly-30;guide rail-31;reaction chamber main body-32;accommodation groove-33;fourth driving element-34;mounting seat-35;first driven pulley-36;

[0096] Multi-channel multi-association inspection parallel pre-processing device-40;gantry-41;first driving element-411;active space-412;transmission plate-413;first slide rail-414;second slide rail-415;sample extraction mechanism-42;second mounting bracket-421;second slide-4211;third driving element-422;extraction assembly-423;syringe device-4231;second loading head-4232;second push plate-4233;piston rod-4234;push rod-4235;elastic element-4236;separation plate-4237;sample pre-processing mechanism-43;first mounting bracket-431;first slide-4311;second driving element-432;pre-processing assembly-433;magnetic bar-4331;magnetic bar device-4332;first loading head-4333;first push plate-4334;connecting rod-4335;

[0097] Membrane breaking assembly-50;seventh driving element-51;fifth mounting bracket-52;membrane breaking head-53;

[0098] PMT assembly-60;mounting bracket-61;third mounting bracket-62;fourth mounting bracket-63;PMT module-64;fifth driving element-65;sixth driving element-66;second driven pulley-67;second synchronous belt pressing plate-68. Embodiments of the present application

[0099] In order to make the purposes, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application and do not limit the present application.

[0100] It should be noted that when a component is referred to as being "fixed" or "set" on another component, it can be directly on the other component or indirectly on the other component. When a component is referred to as being "connected" to another component, it can be directly or indirectly connected to the other component. The terms "upper", "lower", "left", "right", and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. For those skilled in the art, the specific meanings of the above terms can be understood according to the specific circumstances. The terms "first", "second" are only for the convenience of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features. The meaning of "a plurality of" is two or more, unless otherwise specifically limited.

[0101] In order to illustrate the technical solutions provided in the present application, the following will be described in detail in combination with specific drawings and examples.

[0102] Please refer to FIGS. 1 to 7 and 12, the multi-channel multi-association inspection POCT full-automatic chemiluminescence equipment 100 of the embodiment of the present application comprises:

[0103] a mounting frame 10;

[0104] a reaction chamber assembly 30 arranged on the mounting frame 10 and used for loading a multi-association inspection reagent strip 20, the reaction chamber assembly 30 being movable reciprocally along the length direction of the mounting frame 10, the multi-association inspection reagent strip 20 being used for detecting at least two markers, the multi-association inspection reagent strip 20 comprising a liquid storage area 211, the liquid storage area 211 comprising a common liquid area 2112 and a special liquid area 2111 distributed along the length direction of the multi-association inspection reagent strip 20;

[0105] a multi-channel multi-association inspection parallel pre-treatment device 40 arranged on the mounting frame 10 and located above the reaction chamber assembly 30, the multi-channel multi-association inspection parallel pre-treatment device 40 comprising at least two rows of magnetic rods 4331 arranged side by side along the movement direction of the reaction chamber assembly 30, each row of magnetic rods 4331 being at least two, the at least two rows of magnetic rods 4331 being used for transferring magnetic particles in adjacent hole positions of the multi-association inspection reagent strip 20 in the liquid storage area 211;

[0106] a membrane breaking assembly 50 arranged on the mounting frame 10 and located at the rear end of the multi-channel multi-association inspection parallel pre-treatment device 40, the membrane breaking assembly 50 being used for breaking the sealing film of the common liquid area 2112; and

[0107] The PMT assembly 60 is arranged on the mounting frame 10 and above the reaction chamber assembly 30 at the rear end of the film breaking assembly 50, and the reaction chamber assembly 30 is used to move the multi-item detection reagent strip 20 to the PMT assembly 60, and the PMT assembly 60 is used to detect the luminescence value of the detection position of the multi-item detection reagent strip 20.

[0108] In the multi-channel multi-item detection POCT full-automatic chemiluminescence equipment 100, the multi-channel multi-item detection parallel pre-processing device 40 includes at least two rows of magnetic rods 4331 for transferring magnetic particles, and each row of magnetic rods 4331 is at least two, that is, the multi-channel multi-item detection parallel pre-processing device 40 can simultaneously transfer magnetic particles in at least two adjacent reagent holes of a single multi-item detection reagent strip 20 and magnetic particles in adjacent reagent holes of at least two parallel multi-item detection reagent strips 20, thereby realizing analysis and detection of at least two markers, realizing multi-item detection while realizing multi-channel parallel processing, reducing the risk of cross infection, shortening the time of transferring magnetic particles, and ensuring the analysis efficiency of the equipment.

[0109] Moreover, on the basis of the structure of the equipment and in combination with the special design of the multi-item detection reagent strip 20, the operation of breaking the sealing film of the multi-item detection reagent strip 20 does not need to be completely performed by the multi-channel multi-item detection parallel pre-processing device 40, but the sealing film of the common liquid area 2112 can be broken by the rear-end film breaking assembly 50, and the reaction chamber assembly 30 can realize targeted film breaking without moving the multi-item detection reagent strip 20 for a long distance, thereby reducing the repeated and long-distance movement of the reaction chamber assembly 20, reducing the repeated film breaking work of the multi-channel multi-item detection parallel pre-processing device 40, and realizing efficient detection of multiple detection items while controlling the volume of the multi-channel multi-item detection POCT full-automatic chemiluminescence equipment 100.

[0110] Specifically, the multi-channel multi-item detection POCT full-automatic chemiluminescence equipment 100 is roughly in the shape of a rectangular body, and the mounting frame 10 is the basic structure of the multi-channel multi-item detection POCT full-automatic chemiluminescence equipment 100. The mounting frame 10 can include a bottom plate, a plurality of side plates arranged on the bottom plate, a top plate, and the like. The mounting frame 10 surrounded by the above-mentioned bottom plate, a plurality of side plates, and a top plate is also roughly in the shape of a rectangular body.

[0111] The mounting frame 10 is used to carry and install the above-mentioned reaction chamber assembly 30, multi-channel multi-item detection parallel pre-processing device 40, film breaking assembly 50, and PMT assembly 60, and the like. The above-mentioned reaction chamber assembly 30, multi-channel multi-item detection parallel pre-processing device 40, film breaking assembly 50, and PMT assembly 60, and the like are arranged in the space of the mounting frame 10. The mounting frame 10 provides stable support for the above-mentioned components and protects the above-mentioned components from interference from external impurities, water vapor, and the like.

[0112] The reaction chamber assembly 30 can be provided with a plurality of parallelly arranged accommodation grooves 33 extending along the length direction of the reaction chamber assembly 30, and the multi-association reagent strip 20 is loaded in the accommodation grooves 33. The plurality of accommodation grooves 33 can accommodate a plurality of multi-association reagent strips 20, that is, the reaction chamber assembly 30 can drive a plurality of multi-association reagent strips 20 to move in the multi-channel multi-association POCT full-automatic chemiluminescence equipment 100, so that the multi-channel multi-association POCT full-automatic chemiluminescence equipment 100 can sequentially perform multi-channel detection and analysis.

[0113] Please refer to FIG. 4 and FIG. 5, further, the multi-association reagent strip 20 comprises:

[0114] The reagent strip body 21, and the liquid storage area 211 is arranged on the reagent strip body 21;

[0115] The handle 22 arranged at one end of the reagent strip body 21; and

[0116] The sample hole 23, the tip head 24, the at least two disposable magnetic separation sleeves 25, the special liquid area 2111 and the common liquid area 2112 arranged in sequence on the reagent strip body 21 from the handle 22 to the other end of the reagent strip body 21;

[0117] The special liquid area 2111 comprises at least two magnetic micro-particle labeled ligands and at least two enzyme labeled ligands, and the common liquid area 2112 comprises a cleaning liquid and a luminescent substrate liquid.

[0118] In the embodiment of the application, the multi-association reagent strip 20 is a disposable consumable, which can be directly discarded and destroyed after use. The multi-association reagent strip 20 is roughly in the shape of a long strip, and a handle 22 can be arranged at one end thereof. The handle 22 can be provided with anti-slip lines to improve the friction between the multi-association reagent strip 20 and the fingers of the operator, thereby facilitating the operator to hold it tightly.

[0119] The handle 22 is sequentially provided with the sample hole 23, the tip head hole, the at least two disposable magnetic separation sleeve holes, the at least two magnetic labeled ligand holes, the at least two enzyme labeled ligand holes, the plurality of cleaning liquid holes and the plurality of substrate reading holes (i.e. the above-mentioned detection sites) in the direction from one end of the handle 22 to the other end of the multi-association reagent strip 20. The magnetic labeled ligand holes and the enzyme labeled ligand holes constitute the special liquid area 2111, the cleaning liquid holes and the substrate reading holes constitute the common liquid area 2112, and the special liquid area 2111 and the common liquid area 2112 constitute the liquid storage area 211.

[0120] The sample hole 23 is used for adding a blood sample, the tip head hole is provided with a tip head 24, the disposable magnetic separation sleeve hole is provided with a disposable magnetic separation sleeve 25, the magnetic label ligand hole contains a magnetic label ligand, and the enzyme label ligand hole contains an enzyme label ligand. The ligand includes but is not limited to hapten, antigen, monoclonal antibody, polyclonal antibody, and nucleic acid ligand. The washing liquid hole contains a washing liquid, and the substrate reading hole contains a substrate reading. The number of rows of the magnetic rod 4331 is equal to the number of disposable magnetic separation sleeve holes, magnetic label ligand holes, enzyme label ligand holes, and substrate reading holes.

[0121] In addition, after the corresponding reagents are packaged in the corresponding hole positions of the multi-item detection reagent strip 20, the surface of the multi-item detection reagent strip 20 can be heat-sealed with a film to prevent the reagents in the hole positions from leaking or being contaminated, and to facilitate storage and transportation of the multi-item detection reagent strip 20.

[0122] The tip head 24 is a hollow structure with a sharp end, and a through hole is formed in the end, so that the tip head 24 can be used to transfer samples or reagents, and can also be used to break the sealing film on the hole positions. The disposable magnetic separation sleeve 25 can be used to adsorb, mix, wash, and transfer magnetic microparticles. The washing liquid hole can be used to wash the magnetic microparticles. The substrate reading hole is used for chemiluminescence reaction and reading of the luminescence value.

[0123] In the embodiment of the present application, the special liquid area 2111 can be understood as a component directly related to the detection item (such as magnetic bead labeled ligand, enzyme labeled ligand, and pretreatment liquid), wherein the ligand includes hapten, antigen, antibody, and nucleic acid probe, etc. The common liquid area 2112 can be understood as a component that can be shared among detection items (such as washing liquid and luminescence liquid).

[0124] In the common liquid area 2112, even if the film breaking assembly 50 contaminates the liquid in one hole position in the previous film breaking process, and then contaminates the liquid in other hole positions, it will not have a significant impact on the detection result. Therefore, the film breaking assembly 50 is designed to break the sealing film of the common liquid area 2112, reduce the film breaking work of the multi-channel multi-item detection parallel pretreatment device 40, shorten the moving distance of the reaction chamber assembly 30, control the size of the equipment, and improve the multi-item analysis efficiency of the equipment.

[0125] Since the reaction chamber assembly 30 is arranged on the bottom plate of the mounting frame 10, the PMT assembly 60 can be arranged above the bottom plate by a support or the like, that is, the PMT assembly 60 is located opposite the reaction chamber assembly 30. To ensure that the PMT assembly 60 can detect the luminescence values of all the multi-association reagent strips 20 in the reaction chamber assembly 30, the PMT assembly 60 can move up and down and left and right in the mounting frame 10, that is, can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 10), so as to move close to, away from, and between the multi-association reagent strips 20.

[0126] Similarly, the multi-channel multi-association parallel pre-processing device 40 can also be arranged above the bottom plate by a support or the like, that is, the multi-channel multi-association parallel pre-processing device 40 is located opposite the reaction chamber assembly 30. To ensure that the multi-channel multi-association parallel pre-processing device 40 can pre-process all the multi-association reagent strips 20 in the reaction chamber assembly 30, the multi-channel multi-association parallel pre-processing device 40 can also move up and down in the mounting frame 10, that is, can move in the vertical direction, so as to move close to, away from, and between the multi-association reagent strips 20 to transfer samples or reagents, break the sealing film on the multi-association reagent strip 20 hole, and adsorb, mix, clean, and transfer magnetic particles.

[0127] In the embodiment of the present application, the multi-channel multi-association parallel pre-processing device 40 can include two structures, one structure is used in combination with the tip head 24 to transfer samples or reagents and break the sealing film of each hole, and the other structure is used in combination with the disposable magnetic separation sleeve 25 to adsorb, mix, clean, and transfer magnetic particles.

[0128] Further, the multi-channel multi-association parallel pre-processing device 40 includes:

[0129] The gantry 41 arranged on the bottom plate of the mounting frame 10, and the top of the gantry 41 is provided with a first driving element 411;

[0130] The sample extraction mechanism 42 arranged on the gantry 41, and the sample extraction mechanism 42 is in transmission connection with the first driving element 411 and can be lifted and lowered under the driving of the first driving element 411 to suck and spit the sample on the multi-association reagent strip 20;

[0131] The sample pre-processing mechanism 43 arranged on the gantry 41, and the sample pre-processing mechanism 43 is in transmission connection with the first driving element 411 and can be lifted and lowered under the driving of the first driving element 411, and at least two rows of magnetic rods 4331 are arranged on the sample pre-processing mechanism 43 to transfer the magnetic particles on the multi-association reagent strip 20.

[0132] Specifically, the gantry 41 can be made of metal materials, such as stainless steel, iron, aluminum, and various alloys, etc., with high strength, which can improve the service life of the multi-channel pre-processing device 40. The gantry 41 spans the width direction of the installation frame 10, so that the sample extraction mechanism 42 and the sample pre-processing mechanism 43 can span above the reaction chamber assembly 30 to realize multi-channel parallel pre-processing.

[0133] In the embodiment of the present application, the first driving element 411 can be a lead screw motor, which has high motion accuracy and is more accurate and stable in position adjustment. The first driving element 411 arranged at the top of the gantry 41 drives the sample extraction mechanism 42 and the sample pre-processing mechanism 43 to ascend and descend on the gantry 41, so that the sample extraction mechanism 42 and the sample pre-processing mechanism 43 are close to or away from the multi-association reagent strip 20, thereby enabling the sample extraction mechanism 42 and the multi-association reagent strip 20 to be in close contact or away from each other, and the sample pre-processing mechanism 43 and the multi-association reagent strip 20 to be in close contact or away from each other. p The head 24 cooperates to realize the functions of film breaking, sample transfer or reagent transfer, etc., and the sample pre-processing mechanism 43 cooperates with the disposable magnetic separation sleeve 25 on the multi-association reagent strip 20 to realize the adsorption, mixing, washing and transfer of magnetic particles, etc.

[0134] In addition, the sample pre-processing mechanism 43 and the sample extraction mechanism 42 are arranged on opposite sides of the gantry 41, for example, the sample pre-processing mechanism 43 is arranged on the side of the gantry 41 close to the PMT assembly 60, and the sample extraction mechanism 42 is arranged on the other side of the gantry 41.

[0135] In this way, it can not only avoid the problem of space crowding, heavy weight, inconvenient operation and unstable structure of the gantry 41 caused by arranging the sample pre-processing mechanism 43 and the sample extraction mechanism 42 on the same side of the gantry 41, but also enable the sample extraction mechanism 42 and the sample pre-processing mechanism 43 to correspond to different functional reagent holes on the multi-association reagent strip 20, for example, the front part of the multi-association reagent strip 20 needs more participation of the sample extraction mechanism 42, and the rear part needs more participation of the sample pre-processing mechanism 43, which can further improve the pre-processing speed of the multi-channel multi-association parallel pre-processing device 40 on the multi-association reagent strip 20.

[0136] Please refer to FIGS. 6 to 12, further, the sample pre-processing mechanism 43 comprises:

[0137] The first mounting frame 431 arranged on the gantry 41 and in transmission connection with the first driving element 411, the first driving element 411 can drive the first mounting frame 431 to ascend and descend;

[0138] The second driving element 432 arranged on the first mounting frame 431; and

[0139] The front treatment component 433 is arranged on the first mounting frame 431 and is in transmission connection with the second driving element 432. The second driving element 432 can drive the front treatment component 433 to move in the vertical direction to transfer the magnetic microparticles.

[0140] Specifically, the first driving element 411 can drive the first mounting frame 431 to move up and down, thereby driving the sample front treatment mechanism 43 to move up and down to perform corresponding processing such as transferring magnetic microparticles on the multi-test reagent strip 20. The first mounting frame 431 can be substantially in the shape of "L" and include two parts, such as a horizontal extension plate and a vertical extension plate. The second driving element 432 can be arranged on the horizontal extension plate to ensure stable arrangement, thereby providing stable power for the up and down movement of the front treatment component 433.

[0141] The front treatment component 433 is arranged on the vertical extension plate. The second driving element 432 can be a lead screw motor. The lead screw motor has high movement precision and is more accurate and stable in position adjustment. The transmission shaft (i.e., the transmission lead screw) of the lead screw motor extends downward through the horizontal extension plate and is in transmission connection with the front treatment component 433. The transmission connection between the two can be screw connection, which can ensure the stability of the connection between the two. Meanwhile, the second driving element 432 can drive the front treatment component 433 to move in the vertical direction stably and accurately through screw driving, thereby stably and accurately adsorbing and then transferring the magnetic microparticles.

[0142] Further, to ensure that the front treatment component 433 moves up and down stably on the first mounting frame 431, a slide rail extending in the vertical direction can be arranged on the first mounting frame 431, and a slide block adapted to the slide rail can be arranged on the first pushing plate 4334. The stable movement of the front treatment component 433 on the first mounting frame 431 can be realized through the cooperation of the slide rail and the slide block.

[0143] In addition, a first detector (such as a photoelectric switch) can be arranged on one side of the top of the gantry 41, and a first sensing element (such as a baffle) can be arranged on one side of the top of the first mounting frame 431. The first sensing element can be in sensing or out of sensing with the first detector as the first mounting frame 431 moves up and down. When the first mounting frame 431 moves the first sensing element to the first detector to make it out of sensing, it indicates that the sample front treatment mechanism 43 has moved to the set height. At this time, the power supply of the first driving element 411 can be disconnected to avoid overloading and damage of the first driving element 411 and save power consumption.

[0144] Further, one side of the first mounting frame 431 facing the gantry 41 can be provided with a first sliding seat 4311, and one side of the gantry 41 facing the first mounting frame 431 can be provided with a first slide rail 414 extending in the height direction of the gantry 41. The first sliding seat 4311 is in sliding connection with the first slide rail 414.

[0145] The first sliding seat 4311 and the first sliding rail 414 are two groups, which are respectively arranged on the left and right sides of the gantry 41 and the first mounting frame 431. Through cooperation of the two groups of first sliding seat 4311 and first sliding rail 414, the stable lifting of the first mounting frame 431 on the gantry 41 driven by the first driving element 411 can be ensured, and in turn, the stable and accurate lifting of the sample extraction mechanism 42 can be ensured.

[0146] In the embodiment of the present application, the sample extraction mechanism 42 is opposite to the sample pretreatment mechanism 43 on the gantry 41, and the sample extraction mechanism 42 is located in front of the sample pretreatment mechanism 43. The first driving element 411, the second driving element 432 and the third driving element 422 are linearly arranged on the top of the gantry 41, so that the top structure of the multi-channel multi-association inspection parallel pretreatment device 40 is distributed regularly, and the three driving elements are basically concentrated in the middle part of the gantry 41 when force is exerted, so that the gantry 41 is not easy to shake and deviate.

[0147] Please refer to FIG. 9 and FIG. 12, further, the pretreatment assembly 433 comprises:

[0148] A magnetic rod device 4332 arranged on the first mounting frame 431, a plurality of movable through holes are formed in the magnetic rod device 4332, and a first loading head 4333 for loading a disposable magnetic separation sleeve 25 is arranged at the bottom of the magnetic rod device 4332, the first loading head 4333 is in communication with the movable through holes;

[0149] A first push plate 4334 arranged above the magnetic rod device 4332, the first push plate 4334 is in transmission connection with the second driving element 432; and

[0150] A plurality of connecting rods 4335 arranged on the first push plate 4334, at least two rows of magnetic rods 4331 are arranged on the free ends of the plurality of connecting rods 4335 one by one, and the second driving element 432 can drive the first push plate 4334 to drive the magnetic rods 4331 to lift in the corresponding movable through holes, so as to be spaced apart from or pass through the first loading head 4333.

[0151] Specifically, the magnetic rod device 4332 is roughly in the shape of a cuboid, which is distributed along the width direction of the first mounting frame 431, so that the movable through holes therein can be distributed in the width direction of the pretreatment assembly 433 to correspond to the positions of the multi-association inspection reagent strip 20.

[0152] When the disposable magnetic separation sleeve 25 needs to be loaded, the first driving element 411 drives the first mounting frame 431 to descend to the first loading head 4333 to contact and load the disposable magnetic separation sleeve 25, and the two are in interference fit, so as to ensure the stability of the disposable magnetic separation sleeve 25 loaded on the first loading head 4333, and also facilitate separation. The first loading head 4333 is in communication with the movable hole, so that the movable hole is in communication with the disposable magnetic separation sleeve 25, and when the second driving element 432 drives the connecting rod 4335 to drive the magnetic rod 4331 to pass through the first loading head 4333 to extend into the disposable magnetic separation sleeve 25, the magnetic microparticles can be adsorbed through the disposable magnetic separation sleeve 25.

[0153] When the disposable magnetic separation sleeve 25 needs to be separated, the second driving element 432 is controlled to drive the magnetic rod 4331 to descend to abut against the bottom end of the disposable magnetic separation sleeve 25, so that the disposable magnetic separation sleeve 25 is removed from the first loading head 4333. When the second driving element 432 drives the connecting rod 4335 to drive the magnetic rod 4331 to separate from the first loading head 4333 and separate from the disposable magnetic separation sleeve 25, the magnetic field generated by the magnetic rod 4331 disappears, and the magnetic microparticles are separated from the disposable magnetic separation sleeve 25 to realize transfer.

[0154] Based on the design of at least two rows of magnetic rods 4331 in the pretreatment assembly 433, at least two rows of disposable magnetic separation sleeves 25 can be loaded at a time, and at least two magnetic microparticles in the reagent hole can be transferred at a time through at least two rows of disposable magnetic separation sleeves 25. Not only can the transfer speed of the magnetic microparticles be improved to ensure the analysis efficiency of the equipment, but also the multi-association detection function of the equipment can be realized.

[0155] In addition, on the basis of transferring the magnetic microparticles, the pretreatment assembly 433 combined with the disposable magnetic separation sleeve 25 can also be used to transfer the magnetic microparticles to the reagent for reaction and mixing, or separate the magnetic microparticles in the reaction solution to the cleaning solution, or transfer the magnetic microparticles to the substrate reading for reaction and complete the luminescence detection.

[0156] The transmission shaft of the second driving element 432 extends downward through the top of the first mounting frame 431 and the first pushing plate 4334. A fixing member can be provided on the transmission shaft and screwed with the transmission shaft, and the first pushing plate 4334 is fixed on the fixing member. When the transmission shaft of the second driving element 432 acts, the first pushing plate 4334 can be lifted through the fixing member to realize the lifting of the magnetic rod 4331.

[0157] Alternatively, a threaded hole can also be directly provided on the first pushing plate 4334, and a thread is provided on the transmission shaft of the second driving element 432. The transmission shaft is screwed with the first pushing plate 4334 (threaded hole), so as to ensure the stability of the connection between the two, and the second driving element 432 can also drive the first pushing plate 4334 to stably ascend and descend through the threaded driving mode.

[0158] Referring to FIG. 9 and FIG. 12, further, the magnetic rods 4331 are in multiple rows, the multiple rows of magnetic rods 4331 are evenly distributed along the width direction of the first push plate 4334, the number of rows of magnetic rods 4331 is equal to the number of substrate reading holes, so as to realize detection of multiple items, that is, realize multi-association detection.

[0159] Each row of magnetic rods 4331 is multiple, the multiple magnetic rods 4331 in each row are evenly distributed along the length direction of the first push plate 4334, the number of magnetic rods 4331 in each row is equal to the number of multi-association detection reagent strips 20, so as to realize multi-channel parallel processing of multiple multi-association detection reagent strips 20.

[0160] In the embodiment of the application, the magnetic rods 4331 are in 3 rows, that is, 3 items can be detected, the space occupied by the 3 rows of magnetic rods 4331 is not too large, and 3 items can be detected, so that the volume of the multi-channel multi-association detection POCT full-automatic chemiluminescence equipment 100 can be controlled while multi-association detection is realized.

[0161] Of course, in other embodiments, the magnetic rods 4331 can also be in 2 rows or 4 rows or even more, so as to realize detection of different numbers of items.

[0162] The sample pretreatment mechanism 43 in the embodiment of the application can drive the magnetic rods 4331 to reciprocate by lifting and lowering the magnetic rods 4331 through the second driving element 432, the efficiency of magnetic separation is higher, and the multi-channel parallel separation processing further improves the separation and transfer efficiency of magnetic particles. At the same time, the reciprocating motion of the disposable magnetic separation sleeve 25 is realized through the second driving element 432, and the mixing of the reaction liquid and the resuspension of the cleaning liquid can also be completed.

[0163] Exemplarily, the process of the sample pretreatment mechanism 43 transferring magnetic particles is as follows:

[0164] After the sample is injected into the corresponding reagent hole of the multi-association detection reagent strip 20, the reaction chamber assembly 30 drives the multi-association detection reagent strip 20 to move to the corresponding position, so that the sample pretreatment mechanism 43 is located directly above the disposable magnetic rod 4331 sleeve, at this time, the first driving element 411 drives the first mounting frame 431 to lower by a certain height, so that the disposable magnetic rod 4331 sleeve is loaded on the first loading head 4333, the first driving element 411 drives the first mounting frame 431 to rise, and the disposable magnetic rod 4331 sleeve is driven by the first loading head 4333 to rise to a certain height.

[0165] Afterwards, the reaction chamber assembly 30 moves to the position above the corresponding hole of the multi-well test strip 20, the first driving element 411 drives the first mounting frame 431 to lower until the disposable magnetic separation sleeve 25 is inserted into the liquid containing magnetic particles (such as the magnetic labeled ligand as described above), and the second driving element 432 drives the magnetic rod 4331 to lower until the magnetic rod 4331 contacts the bottom of the disposable magnetic separation sleeve 25. At this time, the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve 25. The adsorption of the magnetic particles can be completed by multiple slow lifting and lowering operations.

[0166] After the adsorption of the magnetic particles is completed, the first driving element 411 is controlled to drive the first mounting frame 431 to rise. At this time, the magnetic particles are all adsorbed to the outer wall of the disposable magnetic separation sleeve 25. The reaction chamber assembly 30 is moved to the position above the washing liquid, and the first driving element 411 is controlled to drive the first mounting frame 431 to lower until the disposable magnetic separation sleeve 25 is inserted into the washing liquid. Afterwards, the second driving element 432 is controlled to drive the magnetic rod 4331 to rise from the disposable magnetic separation sleeve 25, so that the magnetic field disappears, and the magnetic particles are separated from the outer wall of the disposable magnetic separation sleeve 25 and fall into the washing liquid.

[0167] In order to accelerate the separation process of the magnetic particles, the first driving element 411 can drive the first mounting frame 431 to repeatedly rise and fall at different frequencies, so that the magnetic particles repeatedly move in the washing liquid, thereby ensuring that the magnetic particles are fully mixed and suspended in the washing liquid. After the magnetic particles are completely separated from the outer wall of the disposable magnetic separation sleeve 25, the first driving element 411 drives the first mounting frame 431 to rise to the initial height, thereby completing the separation, washing and mixing of the magnetic particles. If multiple magnetic separation and washing operations are required, the above operations can be repeated.

[0168] Similarly, if it is required to transfer the magnetic particles to other holes, the first driving element 411 is controlled to drive the first mounting frame 431 to lower until the disposable magnetic separation sleeve 25 is inserted into the bottom of the corresponding liquid surface. Then, the second driving element 432 is controlled to drive the magnetic rod 4331 to lower until the magnetic rod 4331 contacts the bottom end of the disposable magnetic separation sleeve 25, so that the magnetic particles are all adsorbed to the outer wall of the disposable magnetic separation sleeve 25. The first driving element 411 is controlled to drive the first mounting frame 431 to rise.

[0169] Afterwards, the reaction chamber assembly 30 is controlled to move, and the disposable magnetic separation sleeve 25 with the adsorbed magnetic particles is moved to be directly above the target hole position. Then the first driving element 411 is controlled to drive the first mounting frame 431 to descend, and the disposable magnetic separation sleeve 25 is extended into the target liquid. At this time, the second driving element 432 is controlled to drive the magnetic rod 4331 to ascend, so that the magnetic field disappears. The magnetic particles can be gradually separated into the target liquid. The first driving element 411 can be repeatedly controlled to drive the first mounting frame 431 to ascend and descend, so that the disposable magnetic separation sleeve 25 repeatedly moves in the target liquid, thereby accelerating the separation of the magnetic particles.

[0170] Further, referring to FIGS. 6-11 and 13, the sample extraction mechanism 42 includes:

[0171] The second mounting frame 421 is arranged on the gantry 41 and is in transmission connection with the first driving element 411. The first driving element 411 can drive the second mounting frame 421 to ascend and descend;

[0172] The third driving element 422 is arranged on the second mounting frame 421; and

[0173] The extraction assembly 423 is arranged on the second mounting frame 421 and is in transmission connection with the third driving element 422. The third driving element 422 can drive the extraction assembly 423 to ascend and descend to suck and spit the sample.

[0174] Specifically, the first driving element 411 can drive the second mounting frame 421 to ascend and descend, thereby driving the sample extraction mechanism 42 to ascend and descend to perform corresponding processing such as sucking and spitting the sample on the multi-reagent strip 20. The second mounting frame 421 can be substantially in the shape of "L" and include two parts, such as a horizontal extension plate and a vertical extension plate. The third driving element 422 can be arranged on the horizontal extension plate to ensure stable arrangement, thereby providing stable power for the ascent and descent of the extraction assembly 423.

[0175] The extraction assembly 423 is arranged on the vertical extension plate. The third driving element 422 can be a lead screw motor. The lead screw motor has high movement precision and is more accurate and stable in position adjustment. The transmission shaft (i.e., the transmission screw rod) of the lead screw motor extends downward through the horizontal extension plate and is in transmission connection with the extraction assembly 423. The transmission connection between the two can be screw connection, which can ensure the stability of the connection between the two. Meanwhile, the third driving element 422 can drive the extraction assembly 423 to move stably and accurately in the vertical direction through screw driving, thereby stably and accurately contacting the sample to suck and spit the sample.

[0176] In addition, a second detector (such as a photoelectric switch) can be arranged on one side of the top of the gantry 41, and a second sensing member (such as a baffle) can be arranged on one side of the top of the second mounting frame 421. The second sensing member can be in sensing connection or disconnected with the second detector as the second mounting frame 421 ascends and descends.

[0177] When the second mounting frame 421 drives the second sensing member to move to the second detector to disconnect the induction, it indicates that the sample extraction mechanism 42 has moved to the set height, at this time the power supply of the first driving element 411 can be disconnected to avoid the first driving element 411 being damaged due to overload, and also save power consumption.

[0178] Further, the second mounting frame 421 can be provided with a second sliding seat 4211 on one side of the gantry 41, and the gantry 41 can be provided with a second sliding rail 415 extending along the height direction of the gantry 41 on one side of the gantry 41, and the second sliding seat 4211 is in sliding connection with the second sliding rail 415.

[0179] Moreover, the second mounting frame 421 and the second sliding seat 4211 and the second sliding rail 415 on the gantry 41 are two groups, which are respectively arranged on the left and right sides of the gantry 41 and the second mounting frame 421. In this way, through the cooperation between the two groups of second sliding seats 4211 and second sliding rails 415, the stable lifting of the first driving element 411 driving the second mounting frame 421 on the gantry 41 can be ensured, and further the stable and accurate lifting of the sample extraction mechanism 42 can be ensured, and the stable operation of the equipment can be ensured.

[0180] Please refer to FIG. 13, further, the extraction assembly 423 comprises:

[0181] a second injection member 4231 arranged on the second mounting frame 421, a plurality of injection cavities are formed in the second injection member 4231, and a plurality of second loading heads 4232 for loading tip heads 24 are arranged on the bottom of the second injection member 4231, and the plurality of second loading heads 4232 are in one-to-one correspondence with the plurality of injection cavities;

[0182] a second pushing plate 4233 arranged above the second injection member 4231, and the second pushing plate 4233 is in transmission connection with the third driving element 422; and

[0183] a plurality of piston rods 4234 arranged on the second pushing plate 4233, the piston rods 4234 are in movable sealing connection with the injection cavities, and the third driving element 422 can drive the second pushing plate 4233 to drive the piston rods 4234 to ascend and descend in the injection cavities to perform suction and discharge actions.

[0184] Specifically, the second injection member 4231 is roughly in the shape of a cuboid, which is distributed along the width direction of the second mounting frame 421, so that the injection cavities therein can be distributed in the width direction of the extraction assembly 423 to correspond to the positions of the multi-union detection reagent strip 20. The second injection member 4231 also has a certain height to ensure that the space of the injection cavities is large enough, so that the piston rods 4234 can generate a large enough suction and discharge force when moving in the injection cavities.

[0185] The second loading head 4232 is in interference fit with the tip head 24, so as to ensure the stability of the tip head 24 loaded on the second loading head 4232, and facilitate the tip head 24 to be removed by pushing. When the first driving element 411 drives the second mounting frame 421 to lower the extraction assembly 423, the tip head 24 loaded on the second loading head 4232 can break the corresponding sealing film on the multi-union detection reagent strip 20. The second loading head 4232 is in communication with the syringe cavity, so that the syringe cavity is in communication with the tip head 24, and when the piston rod 4234 is pushed to rise and fall in the syringe cavity, the tip head 24 can be used to suck and spit the sample.

[0186] The transmission shaft of the third driving element 422 extends downward through the top of the second mounting frame 421 and the second pushing plate 4233. A fixing member in thread connection with the transmission shaft can be arranged on the transmission shaft, and the second pushing plate 4233 is fixed on the fixing member. When the transmission shaft of the third driving element 422 acts, the second pushing plate 4233 can be driven to rise and fall by the fixing member, so as to realize the rising and falling of the piston rod 4234.

[0187] Alternatively, a threaded hole can be arranged on the second pushing plate 4233, and a thread can be arranged on the transmission shaft of the third driving element 422. The transmission shaft is in thread connection with the second pushing plate 4233. In this way, the connection stability between the transmission shaft and the second pushing plate 4233 can be ensured, and the third driving element 422 can also drive the second pushing plate 4233 to rise and fall by thread driving.

[0188] In the embodiment, the end of the piston rod 4234 in the syringe cavity can be sealed with a sealing ring (such as a rubber ring or a plastic ring, etc.). When the piston rod 4234 is driven upward by the second pushing plate 4233 to rise in the syringe cavity, a negative pressure is generated in the syringe cavity to make the tip head 24 suck the sample. When the piston rod 4234 is pushed downward by the second pushing plate 4233 to fall in the syringe cavity, a positive pressure is generated in the syringe cavity to make the tip head 24 spit the sample.

[0189] Further, in order to ensure that the second pushing plate 4233 stably drives the piston rod 4234 to rise and fall, a slide rail extending in the vertical direction is arranged on the syringe 4231, and a slide block adapted to the slide rail is arranged on the second pushing plate 4233. The slide rail and the slide block are matched to realize the stable movement of the second pushing plate 4233 relative to the second mounting frame 421, and ensure the stable driving of the piston rod 4234. The slide rail and the slide block are two groups, which are respectively arranged on the left and right sides of the sample extraction mechanism 42, to further ensure the stable rising and falling of the second pushing plate 4233.

[0190] More, the photoelectric switch can be arranged on the top of the second mounting frame 421, and the baffle can be arranged on the corresponding side of the second push plate 4233. When the second push plate 4233 drives the baffle to move to the photoelectric switch and the photoelectric switch is disconnected, it indicates that the second push plate 4233 has moved to the set height, that is, the piston rod 4234 has been reset. At this time, the power supply of the third driving element 422 can be disconnected to avoid damage of the third driving element 422 due to overloading.

[0191] Please combine FIG. 9 and FIG. 13. In the embodiment of the present application, the plurality of syringe cavities are uniformly distributed along the length direction of the syringe device 4231; the plurality of second loading heads 4232 are uniformly distributed along the length direction of the syringe device 4231; and the plurality of piston rods 4234 are uniformly distributed along the length direction of the second push plate 4233. That is, the plurality of piston rods 4234, the plurality of syringe cavities and the plurality of piston rods 4234 correspond one by one, thereby realizing multi-channel parallel processing of the plurality of multi-union detection reagent strips 20.

[0192] Please continue to refer to FIG. 13. Further, the sample extraction mechanism 42 further comprises:

[0193] The push rod 4235 is arranged in the syringe device 4231 in a liftable manner, and the top end of the push rod 4235 is spaced apart from the second push plate 4233;

[0194] The elastic element 4236 is arranged in the syringe device 4231 and surrounds the push rod 4235. When the push rod 4235 is lifted or lowered relative to the syringe device 4231, the elastic element 4236 is simultaneously stretched or compressed; and

[0195] The separation plate 4237 is arranged at the bottom of the syringe device 4231, the second loading head 4232 passes through the separation plate 4237, the bottom end of the push rod 4235 is connected with the separation plate 4237, and the push rod 4235 can drive the separation plate 4237 to be lifted or lowered relative to the second loading head 4232.

[0196] In the embodiment of the present application, the separation plate 4237 is provided with a through hole, and the size of the through hole is smaller than the size of the connection between the tip head 24 and the second loading head 4232. Therefore, the tip head 24 loaded on the second loading head 4232 can be removed through the arrangement of the separation plate 4237.

[0197] Specifically, since the top end of the push rod 4235 is spaced apart from the second push plate 4233, when the second push plate 4233 is pushed downward by the third driving element 422 to a certain height to contact the top end of the push rod 4235, the second push plate 4233 pushes the push rod 4235 to descend in the syringe device 4231, thereby pushing the separation plate 4237 at the bottom of the syringe device 4231 to descend and abut against the tip head 24, so as to push the tip head 24 to separate from the second loading head 4232.

[0198] After the separation of the tip head 24 is completed, the third driving element 422 stops driving, and the elastic element 4236 is stretched to generate an upward pushing force on the pushing rod 4235, so as to drive the separation plate 4237 to reset. The compression of the elastic element 4236 can provide a certain buffering force for the downward movement of the pushing rod 4235, so as to avoid that the tip head 24 is damaged due to too fast downward movement of the pushing rod 4235, or that the tip head 24 is pressed on the multi-association reagent strip 20 to cause the multi-association reagent strip 20 to be offset or shaken.

[0199] In the embodiment of the present application, the pushing rod 4235 and the elastic element 4236 are two, which are respectively arranged on the two sides of the syringe element 4231, so as to ensure that the pushing rod 4235 stably pushes the separation plate 4237, and further ensure the separation effect of the tip head 24 and the stable reset of the elastic element 4236 on the separation plate 4237.

[0200] Exemplarily, the process of the sample extraction mechanism 42 sucking and spitting the sample (and transferring / mixing the reagent) is as follows:

[0201] The reaction chamber assembly 30 drives the multi-association reagent strip 20 to move to the corresponding position, the first driving element 411 drives the second mounting frame 421 to descend, and the second mounting head 4232 is fixedly connected with the tip head 24 on the multi-association reagent strip 20.

[0202] After the loading of the tip head 24 is completed, the reaction chamber assembly 30 drives the multi-association reagent strip 20 to move, so that the tip head 24 moves above the sample hole 23, the third driving element 422 drives the piston rod 4234 to descend in the syringe cavity to a certain height or to the lowest point, then the first driving element 411 drives the second mounting frame 421 to descend to a certain height, so that the tip of the tip head 24 extends into the sample, the third driving element 422 drives the piston rod 4234 to ascend to suck the sample through the tip head 24. Then, the first driving element 411 drives the second mounting frame 421 to ascend, so that the tip head 24 is separated from the sample liquid surface, the reaction chamber assembly 30 drives the multi-association reagent strip 20 to move, so that the tip head 24 with the sample is moved above the target hole position.

[0203] The first driving element 411 drives the second mounting frame 421 to descend, so that the tip head 24 with the sample is lowered, and the tip of the tip head 24 extends below the liquid surface of the reagent, the third driving element 422 drives the piston rod 4234 to descend, so that the sample in the tip head 24 is injected into the reagent. Then, the first driving element 411 drives the second mounting frame 421 to ascend, so that the tip head 24 is separated from the reagent, and the third driving element 422 drives the piston rod 4234 to ascend to the original position, so as to realize the sucking and spitting transfer of the sample, and then the tip head 24 is retreated into the tip head hole.

[0204] The reagent transfer process is the same as the sample transfer process, which will not be described here.

[0205] If multiple pipetting is required, the tip head 24 is repeatedly loaded and the actions of suction and injection are repeated. In addition, the sample extraction mechanism 42 can also be used for mixing reagents. The third driving element 422 drives the piston rod 4234 to repeatedly rise and fall in the syringe cavity, and the tip head 24 repeatedly sucks and discharges under the liquid surface of the reagent, so that the reagents or samples required for reaction are fully mixed and reacted.

[0206] Referring to FIGS. 8, 10 and 11, the gantry 41 is further provided with a moving space 412, the transmission shaft of the first driving element 411 passes through the moving space 412, the transmission shaft is sleeved with a transmission plate 413, the transmission shaft is provided with threads, and the transmission plate 413 is provided with screw holes. Therefore, when the transmission shaft moves, the transmission plate 413 can be synchronously lifted and lowered in the moving space 412 through thread transmission.

[0207] In addition, the first mounting frame 431 is provided with a first connecting portion on the side facing the gantry 41, the first connecting portion is formed by extending the vertical extension plate of the first mounting frame 431 toward the gantry 41, the second mounting frame 421 is provided with a second connecting portion on the side facing the gantry 41, the second connecting portion is formed by extending the vertical extension plate of the second mounting frame 421 toward the gantry 41, and the first connecting portion and the second connecting portion are connected with the transmission plate 413 through fasteners (such as screws). Therefore, when the transmission plate 413 is lifted and lowered with the transmission shaft of the first driving element 411, the second mounting frame 421 and the first mounting frame 431 can be lifted and lowered, that is, the sample extraction mechanism 42 and the sample pretreatment mechanism 43 can be lifted and lowered on the gantry 41.

[0208] Referring to FIGS. 2, 3 and 14, the reaction chamber assembly 30 further includes:

[0209] a guide rail 31 provided on the bottom plate of the mounting frame 10;

[0210] a reaction chamber body 32 provided on the guide rail 31, the bottom of the reaction chamber body 32 is provided with a guide block in sliding connection with the guide rail 31, and the reaction chamber body 32 is provided with a plurality of evenly spaced accommodation grooves 33 for loading a plurality of test reagent strips 20, the accommodation grooves 33 extend along the length direction of the reaction chamber body 32;

[0211] a fourth driving element 34 provided on the bottom plate of the mounting frame 10 and located at the rear end of the guide rail 31, and a first driving pulley is provided on the transmission shaft of the fourth driving element 34;

[0212] The mounting seat 35 is arranged on the bottom plate of the mounting frame 10 and located at the front end of the guide rail 31, and the first driven pulley 36 is arranged on the mounting seat 35, and the first driving pulley is in transmission connection with the first driven pulley 36 through the belt.

[0213] The first synchronous belt pressing plate is arranged on one side of the reaction chamber body 32 and connected with the belt.

[0214] Specifically, the guide rail 31 extends along the length direction of the mounting frame 10, and the sliding connection of the guide rail 31 and the guide block enables the reaction chamber assembly 30 to move stably along the length direction of the mounting frame 10. The shape of the accommodating groove 33 is matched with the shape of the multi-parallel detection reagent strip 20, so that the multi-parallel detection reagent strip 20 can be stably loaded on the reaction chamber assembly 30, and the stability in the moving process and the pretreatment process is maintained, the deviation and shaking are avoided, and the leakage of reagents from the multi-parallel detection reagent strip 20 is avoided.

[0215] The fourth driving element 34 is located at the rear end of the mounting frame 10, and the mounting seat 35 is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the reaction chamber assembly 30 in the mounting frame 10 can be long enough to better cooperate with the movement of the multi-channel multi-parallel detection parallel pretreatment device 40.

[0216] The transmission efficiency of the transmission structure composed of the first driving pulley, the belt, the first synchronous belt pressing plate and the first driven pulley 36 is high, and the structure is simple and has sufficient power. Combined with the arrangement of the guide rail 31, the stable and rapid movement of the reaction chamber assembly 30 in the mounting frame 10 can be ensured, and the movement efficiency of the reaction assembly is improved.

[0217] Furthermore, a photoelectric switch for detecting the position of the reaction chamber body 32 in real time can be arranged on the bottom plate of the mounting frame 10, and a baffle can be arranged on the reaction chamber body 32. When the reaction chamber body 32 drives the baffle to move to the corresponding position, the baffle reaches the photoelectric switch and causes the photoelectric switch to be disconnected, which indicates that the reaction chamber assembly 30 has reached the set position. At this time, the power supply of the fourth driving element 34 can be disconnected, so as to avoid overloading and failure caused by continuous work of the fourth driving element 34, and save power consumption.

[0218] In addition, a heating module is further arranged at the bottom of the reaction chamber body 32, and the heating temperature of the heating module can be constant at human body temperature, i.e. 37℃. The temperature in the reaction chamber body 32 is constant within the preset value range, so that the reagents in the multi-parallel detection reagent strip 20 meet the temperature conditions of chemiluminescence determination.

[0219] Please refer to FIG. 2, FIG. 15 and FIG. 16, further, the PMT assembly 60 comprises:

[0220] A mounting bracket 61 is arranged on the bottom plate of the mounting frame 10;

[0221] A third mounting bracket 62 is arranged on the mounting bracket 61;

[0222] A fourth mounting bracket 63 is arranged at the bottom of the third mounting bracket 62;

[0223] A PMT module 64 is arranged on the fourth mounting bracket 63;

[0224] A fifth driving element 65 is arranged at the top of the third mounting bracket 62 and is in driving connection with the fourth mounting bracket 63, and the fifth driving element 65 can drive the fourth mounting bracket 63 to move up and down to drive the PMT module 64 to move up and down;

[0225] A sixth driving element 66 and a second driven pulley 67 are respectively arranged at the top of the two sides of the mounting bracket 61, the transmission shaft of the sixth driving element 66 is provided with a second driving pulley, and the second driving pulley is in driving connection with the second driven pulley 67 through a belt; and

[0226] A second synchronous belt pressing plate 68 is arranged on the third mounting bracket 62, and the second synchronous belt pressing plate 68 is connected with the belt.

[0227] In the embodiment, the structure of the mounting bracket 61 can be similar to that of the gantry 41, which also spans the width direction of the mounting frame 10, so that the PMT module 64 can move above the reaction chamber assembly 30 to realize chemiluminescence detection. In addition, the mounting bracket 61 can also be made of metal materials, such as stainless steel, iron, aluminum and various alloys, etc., which has high strength and can improve the service life of the PMT assembly 60.

[0228] The third mounting bracket 62 is used for mounting the fifth driving element 65 to provide stable support for the fifth driving element 65, so that the fifth driving element 65 is stably arranged at the top of the mounting bracket 61. The fourth mounting bracket 63 is used for mounting the PMT module 64, which is in driving connection with the fifth driving element 65, so that the PMT module 64 can move up and down under the driving of the fifth driving element 65. The third mounting bracket 62 is in driving connection with the belt, so that the fourth mounting bracket 63 and the PMT module 64 thereon can move horizontally, and the PMT module 64 can move up, down, left and right on the mounting bracket 61 through the combination of the fifth driving element 65 and the sixth driving element 66.

[0229] In this embodiment, the fifth driving element 65 can be a lead screw motor. The fifth driving element 65, located on the top of the mounting bracket 61, drives the fourth mounting bracket 63 to rise and fall, thereby driving the PMT module 64 to rise and fall. This allows the PMT assembly 60 to move closer to or further away from the multi-test strip 20. The lead screw motor has high motion precision, making the position adjustment of the PMT module 64 more accurate and stable. This enables the PMT assembly 60 to accurately and stably detect the luminescence value of the detection position on the multi-test strip 20.

[0230] The sixth drive element 66 can be a stepper motor, which is located on the top side of the mounting bracket 61 (e.g., the right side), while the second driven pulley 67 is located on the top other side of the mounting bracket 61 (e.g., the left side), so that the connection between the two can cover the length direction of the mounting bracket 61, thereby enabling the movement of the PMT module 64 on the mounting bracket 61 to cover the width range of the mounting frame 10.

[0231] The transmission structure consisting of the second active pulley, belt, second synchronous belt pressure plate 68 and second driven pulley 67 has high transmission efficiency, simple structure and sufficient power. The belt can increase the moving speed of PMT module 64 and thus improve detection efficiency, so that PMT component 60 can move and switch quickly between the various multi-unit test strips 20 in reaction chamber component 30 to perform luminescence value detection respectively.

[0232] Please refer to Figures 2, 15, and 16. Furthermore, the membrane breaking assembly 50 includes:

[0233] The seventh drive element 51 is located at the top of the mounting bracket 61;

[0234] A fifth mounting bracket 52 is mounted on the mounting bracket 61 and located below the seventh drive element 51. The fifth mounting bracket 52 is drively connected to the seventh drive element 51 and can be raised and lowered under the drive of the seventh drive element 51; and

[0235] Multiple film-breaking heads 53 are located at the bottom of the fifth mounting frame 52, and the multiple film-breaking heads 53 are evenly distributed at intervals along the length direction of the fifth mounting frame 52.

[0236] In this embodiment, the membrane breaking component 50 and the PMT component 60 share the mounting bracket 61, which improves the utilization rate of the mounting bracket 61, controls the internal volume of the device, and promotes the miniaturization of the device. The membrane breaking component 50 is located on the side of the mounting bracket 61 closer to the multi-channel multi-test parallel pretreatment device 40. This closer proximity to the multi-test reagent strip 20 shortens the movement distance of the multi-test reagent strip 20, allowing for faster membrane breaking in the common liquid area 2112 and improving the analytical efficiency of the device.

[0237] The seventh driving element 51 can be a lead screw motor. The seventh driving element 51 arranged on the top of the mounting bracket 61 drives the fifth mounting bracket 52 to lift to drive the membrane breaking head 53 to lift, so that the membrane breaking head 53 can be close to or away from the multi-association reagent strip 20, and then the sharp end of the membrane breaking head 53 breaks the sealing film and switches between different reagent holes. Moreover, the lead screw motor has high movement accuracy, and the position adjustment of the membrane breaking head 53 is more accurate and stable, so that the membrane breaking head 53 can accurately and stably break the sealing film of the common liquid area 2112, and avoid shaking and misplacement caused by pressing the multi-association reagent strip 20.

[0238] The number of the membrane breaking head 53 is the same as that of the multi-association reagent strip 20, so that all the multi-association reagent strips 20 can be broken at the same time, the processing speed is improved, and the analysis efficiency of the equipment is improved. Further, the membrane breaking head 53 can also be arranged in multiple rows, for example, the number of rows is the same as the number of reagent holes in the common liquid area 2112. In this way, the membrane breaking assembly 50 only needs to be operated once to break all the sealing films of the common liquid area 2112, the membrane breaking efficiency is improved, and the analysis efficiency of the equipment is improved.

[0239] In the embodiment of the present application, the transmission shaft of the seventh driving element 51 extends downward through the top of the fifth mounting bracket 52. A fixing member threadedly connected with the transmission shaft can be arranged on the transmission shaft, and the fifth mounting bracket 52 is fixed on the fixing member. When the transmission shaft of the seventh driving element 51 operates, the fifth mounting bracket 52 is lifted to realize the lifting of the membrane breaking head 53 through the fixing member.

[0240] Alternatively, a threaded hole can be arranged on the fifth mounting bracket 52, and a thread is arranged on the transmission shaft of the seventh driving element 51. The transmission shaft is threadedly connected with the fifth mounting bracket 52 (threaded hole). In this way, the connection stability between the two can be ensured, and the seventh driving element 51 can stably drive the fifth mounting bracket 52 to lift through the threaded driving mode.

[0241] In the embodiment of the present application, the membrane breaking head 53 and the fifth mounting bracket 52 can be detachably arranged. For example, the membrane breaking head 53 is arranged on the fifth mounting bracket 52 through a screw. The stability of the membrane breaking head 53 on the fifth mounting bracket 52 can be ensured, and the membrane breaking head 53 is convenient to disassemble and assemble. When the membrane breaking head 53 is damaged, the membrane breaking head 53 is convenient to replace.

[0242] Further, in order to stably drive the fifth mounting bracket 52 to lift by the seventh driving element 51, a slide rail extending in the vertical direction can be arranged on the mounting bracket 61, and a slide block matched with the slide rail can be arranged on the fifth mounting bracket 52. The stable movement of the fifth mounting bracket 52 relative to the mounting bracket 61 is realized through the cooperation of the slide rail and the slide block. The slide rail and the slide block are two groups and are arranged on the left and right sides of the above two groups, respectively. The stable lifting of the fifth mounting bracket 52 is further ensured.

[0243] Further, a photoelectric switch can be arranged on the top of the mounting bracket 61, and a baffle can be arranged on the corresponding side of the fifth mounting bracket 52. When the fifth mounting bracket 52 moves the baffle to the photoelectric switch, the photoelectric switch is turned off, indicating that the fifth mounting bracket 52 has moved to the set height reset position. At this time, the power supply of the seventh driving element 51 can be turned off to avoid overloading and damage of the seventh driving element 51, and to save power consumption.

[0244] Further, the multi-channel multi-association POCT full-automatic chemiluminescence equipment 100 can further include control modules, electrical modules, display modules, image acquisition modules, heat dissipation modules, and alarm modules. The control modules are electrically connected with the electrical modules, the display modules, the image acquisition modules, the heat dissipation modules, and the alarm modules. The electrical modules are also electrically connected with the display modules, the image acquisition modules, the heat dissipation modules, and the alarm modules.

[0245] For example, the electrical modules can be used to provide power support for the entire equipment, and the control modules can be used to control the operation of the equipment, such as controlling the opening and closing of the driving elements, the opening and closing of the heating modules, the display of the display modules, and the image acquisition and conversion of the image acquisition modules. The display modules can be used to display the running parameters and project analysis results of the equipment. The image acquisition modules can be used to take pictures and monitor the pre-processing work of the multi-channel multi-association POCT parallel pre-processing device 40. When an abnormality is monitored, the alarm module (such as an audible and visual alarm or a display alarm) can be controlled by the control module to issue a corresponding warning. The heat dissipation modules can be used to dissipate heat from the equipment to avoid overheating and affect normal operation.

[0246] The control modules, the electrical modules, the display modules, the image acquisition modules, the heat dissipation modules, and the alarm modules are not related to the application points of the present application, and therefore will not be described in detail here. Only their connection relationship and basic functions will be described. If there is any ambiguity, those skilled in the art can refer to the structure, position, and function of the control modules, the electrical modules, the display modules, the image acquisition modules, the heat dissipation modules, and the alarm modules in related technologies.

[0247] The above is only an optional embodiment of the present application and is not intended to limit the present application. Those skilled in the art can make various changes and modifications to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the scope of the claims of the present application.

Claims

1. A multi-channel multi-project POCT full-automatic chemiluminescence equipment, characterized in that, The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. 2.The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 1, wherein, The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. 3.The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 2, characterized in that, The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device.

4. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 3, characterized in that, The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. The application relates to a multi-channel multi-parallel detection front-end processing device. 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5. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 4, characterized in that, The magnetic rods are arranged in multiple rows, and the multiple rows of magnetic rods are uniformly distributed along the width direction of the first push plate. Each row of the magnetic rods is a plurality of magnetic rods, and the plurality of magnetic rods in each row are uniformly distributed along the length direction of the first push plate. 6.The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 3, characterized in that, The sample extraction mechanism comprises: A second mounting frame arranged on the gantry and in transmission connection with the first driving element, and the first driving element can drive the second mounting frame to ascend and descend; A third driving element arranged on the second mounting frame; and An extraction assembly arranged on the second mounting frame and in transmission connection with the third driving element, and the third driving element can drive the extraction assembly to ascend and descend to suck and spit samples.

7. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 6, characterized in that, The extraction assembly comprises: An injection device arranged on the second mounting frame, a plurality of injection cavities are formed in the injection device, and a plurality of second loading heads for loading tip heads are arranged at the bottom of the injection device, and the plurality of second loading heads are in one-to-one correspondence with the plurality of injection cavities; A second push plate arranged above the injection device, the second push plate is in transmission connection with the third driving element; and A plurality of piston rods arranged on the second push plate, the piston rods are in movable sealing connection with the injection cavities, and the third driving element can drive the second push plate to drive the piston rods to ascend and descend in the injection cavities to perform sucking and spitting actions.

8. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 7, characterized in that, The sample extraction mechanism further comprises: A push rod movably penetrating the injection device, the top end of the push rod is spaced from the second push plate; An elastic element sleeved on the push rod in the injection device, the elastic element is simultaneously stretched or compressed when the push rod ascends and descends relative to the injection device; and A separation plate arranged at the bottom of the injection device, the second loading heads pass through the separation plate, the bottom end of the push rod is connected with the separation plate, and the push rod can drive the separation plate to ascend and descend relative to the second loading heads. 9.The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 7, characterized in that, The plurality of injection cavities are uniformly distributed along the length direction of the injection device, the plurality of second loading heads are uniformly distributed along the length direction of the injection device, and the plurality of piston rods are uniformly distributed along the length direction of the second push plate.

10. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 6, characterized in that, The sample extraction mechanism is opposite to the sample pretreatment mechanism, and the sample extraction mechanism is located in front of the sample pretreatment mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

11. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 6, characterized in that, An activity space is arranged on the gantry, a transmission shaft of the first driving element penetrates the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can ascend and descend in the activity space when the transmission shaft operates. The first mounting frame is provided with a first connecting portion on one side thereof facing the gantry, and the second mounting frame is provided with a second connecting portion on one side thereof facing the gantry, and the first connecting portion and the second connecting portion are connected with the transmission plate.

12. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 6, characterized in that, The first mounting frame is provided with a first sliding seat on one side thereof facing the gantry, and the gantry is provided with a first sliding rail on one side thereof facing the first mounting frame, the first sliding rail extends along the height direction of the gantry, and the first sliding seat is in sliding connection with the first sliding rail. The second mounting frame is provided with a second sliding seat on one side thereof facing the gantry, and the gantry is provided with a second sliding rail on one side thereof facing the second mounting frame, the second sliding rail extends along the height direction of the gantry, and the second sliding seat is in sliding connection with the second sliding rail.

13. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 6, characterized in that, One side of the top of the first mounting frame is provided with a first sensing element, and one side of the top of the gantry is provided with a first detector, the first sensing element can be in induction or break induction with the first detector as the first mounting frame is lifted or lowered. One side of the top of the second mounting frame is provided with a second sensing element, and one side of the top of the gantry is provided with a second detector, the second sensing element can be in induction or break induction with the second detector as the second mounting frame is lifted or lowered.

14. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 1, characterized in that, The reaction bin assembly comprises: a guide rail provided on the bottom plate of the mounting frame; a reaction bin body provided on the guide rail, the bottom of the reaction bin body is provided with a guide block in sliding connection with the guide rail, and a plurality of evenly distributed accommodation grooves for loading the multi-connection detection reagent strips are provided on the reaction bin body and extend along the length direction of the reaction bin body; a fourth driving element provided on the bottom plate of the mounting frame and located at the rear end of the guide rail, a first driving pulley is provided on the transmission shaft of the fourth driving element; a mounting seat provided on the bottom plate of the mounting frame and located at the front end of the guide rail, a first driven pulley is provided on the mounting seat, and the first driving pulley is in transmission connection with the first driven pulley through a belt; and a first synchronous belt pressing plate provided on one side of the reaction bin body, the first synchronous belt pressing plate is connected with the belt.

15. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 1, characterized in that, The PMT assembly comprises: a mounting support provided on the bottom plate of the mounting frame; a third mounting frame provided on the mounting support; a fourth mounting frame provided at the bottom of the third mounting frame; a PMT module provided on the fourth mounting frame; a fifth driving element provided on the top of the third mounting frame and in transmission connection with the fourth mounting frame, the fifth driving element can drive the fourth mounting frame to lift or lower to drive the PMT module to lift or lower; a sixth driving element and a second driven pulley respectively provided on the top of the two sides of the mounting support, a second driving pulley is provided on the transmission shaft of the sixth driving element, the second driving pulley is in transmission connection with the second driven pulley through a belt; and a second synchronous belt pressing plate provided on the third mounting frame, the second synchronous belt pressing plate is connected with the belt.

16. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 15, characterized in that, The membrane breaking assembly comprises: a seventh driving element provided on the top of the mounting support; A fifth mounting bracket is arranged on the mounting bracket and below the seventh driving element, and the fifth mounting bracket is in transmission connection with the seventh driving element and can be lifted under the driving of the seventh driving element. A plurality of membrane breaking heads are arranged on the bottom of the fifth mounting bracket, and the plurality of membrane breaking heads are uniformly distributed along the length direction of the fifth mounting bracket.

17. The multi-channel multi-project POCT full-automatic chemiluminescence equipment according to claim 1, characterized in that, The multi-union detection reagent strip comprises: A reagent strip main body, and the liquid storage area is arranged on the reagent strip main body; A handle arranged on one end of the reagent strip main body; and A sample hole, a tip head, at least two disposable magnetic separation sleeves, the special liquid area and the common liquid area arranged on the reagent strip main body in sequence from the handle to the other end of the reagent strip main body. The special liquid area comprises at least two kinds of magnetic micro-particle labeled ligands and at least two kinds of enzyme labeled ligands, and the common liquid area comprises a cleaning liquid and a luminescent substrate liquid.

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