Luer connection and corresponding luer connector

Abstract

The invention relates to a Luer connection between a first component (15) of a medical fluid line system, in particular a CSTD component having a dry-break coupling, and a second component, such as a syringe, which can be connected to the first component (15) by means of a releasable screw connection (52) via a Luer connector (20). In order to create a Luer connection with which production and operating costs can be reduced with minimal operating safety risk, the Luer connector (20) is attached to the first component (15) in such a way that the Luer connector is fixed to the first component (15) for conjoint rotation in an initial use state and, after applying a specified threshold torque, can be brought into a second use state, in which the Luer connector can be freely rotated relative to the first component (15) in said first component at least in the direction opposite the thread direction of the releasable screw connection, preferably in both rotatoinal directions.

Description

[0001] Luer connection and associated Luer connector

[0002] Description

[0003] The present disclosure relates to a Luer connection between a first component of a medical fluid piping system, in particular a CSTD component with a dry-break coupling, and a second component, such as a syringe, which can be connected to the first component via a Luer connector using a detachable Luer screw connection. The disclosure further relates to a Luer connector adapted for this Luer connection.

[0004] Carcinogenic, mutagenic, or reprotoxic (CMR) drugs, used for example in cancer therapy, primarily damage rapidly growing tumor cells during therapeutic use. Many of these drugs also possess carcinogenic properties due to their mechanism of action. To prevent contact between CMR drugs and individuals not undergoing treatment, so-called "closed system transfer devices" (CSTDs) are increasingly used in the manufacture and administration of ready-to-use preparations. A key component of CSTDs are coupling systems, also known as dry breaks, which enable the safe transfer of CMR drugs and create a dry seal after the connection is broken, thus protecting the surrounding area from contamination (e.g., through leakage or droplet formation on the surfaces of the coupling partners after disconnection).Coupling systems of this type are generally associated with terms such as "dry connection", "automatic self-sealing technology", "closed connection" and "dry break" and represent important components for the realization of CSTDs, which are becoming increasingly important for the use of so-called "ready-to-use" drugs (see CDC guideline USP 800).

[0005] Such a so-called dry break coupling consists of two parts: a male dry break and a female dry break. Several manufacturers of CSTD dry breaks are already on the market, for example under the names Chemfort (from Simpliva), ChemoLock (from ICU medical), Equashield (from Equashield), or PhaSeal (from BD).

[0006] One embodiment of such a "Vial-to-Vein Closed System Drug-Transfer Device" (CSTD system), i.e., a closed / self-sealing vial liquid withdrawal and transfer device, is described by way of example in publication WO 2022 / 232405 A1, the disclosure of which is expressly incorporated into the present application, and shown in Figures 1 and 2, to which reference is made here. Figures 1A and 1B show sectional views of the CSTD system in the decoupled (Figure 1A) and coupled (Figure 1B) states, respectively. Figure 2 shows the CSTD system in a perspective view.

[0007] As shown in Figures 1A and 2, this CSTD system 1 comprises a first coupling adapter part 3, hereinafter referred to as the Female Dry Break, with a housing 4 in which an axially extending through-flow fluid channel or fluid channel component 5 is formed or inserted, and which is closed at a proximal flange side 7 by means of a membrane 9. The fluid channel component 5, together with the housing 4, forms a (Luer Lock) coupling 6 at the distal end section of the first coupling adapter part 3, with which the first coupling adapter part 3 can be connected to a medical device, for example, to a vial / ampoule containing a medical drug. The housing 4 or the fluid channel component 5 of the first coupling adapter part 3 also forms a number of locking elements in the form of undercuts 11.

[0008] The CSTD system 1 further comprises a second coupling adapter part 13, hereinafter referred to as the Male Dry Break, with a housing 15 which forms a number of detent elements in the form of undercuts 16, a slide or piston 17 which is relatively displaceable in the housing 15, a hollow needle 19 which is relatively displaceable in the piston 17 and which is held at its proximal end section (away from the needle tip) by a retaining anchor or an anchor sleeve 20 in the housing 15, and a number of elastically deformable detent arms 21 which are fixed or formed on the piston 17 and are designed and configured to engage with both the undercuts 11 of the first coupling adapter part 3 and the undercuts 16 of the second coupling adapter part 13.

[0009] For the relatively movable mounting of the hollow needle 19 in the piston 17, the piston has a (central) through-channel 23, which is closed at a distal coupling or flange side 25 of the second coupling adapter part 13 by means of a membrane 27.

[0010] As can be seen from the illustration in Figure 2, the arrangement is such that the two housing parts 4 and 15 can be inserted into one another in a rotationally secure manner. This is made possible by the fact that the housing 15 has a rectangular receiving opening 18 in cross-section, in which the housing 4 of the first coupling adapter part 3 can be received with a snug fit, wherein the cheeks 10 of the housing 4, in conjunction with the inner side walls 12 of the receiving opening 18, perform a guiding function and ensure rotational security.

[0011] Fig. 1B shows the function of the CSTD system 1 according to Fig. 1A.

[0012] Accordingly, to establish a fluid connection between the first and second coupling adapter parts 3, 13, the diaphragm 27 of the second coupling adapter part 13 is pressed against the diaphragm 9 of the first coupling adapter part 3 in a sealing manner during a first movement window. During a second movement window, the housing 15 of the second coupling adapter part 13 is moved further forward towards the housing 4 of the first coupling adapter part 3. This further forward movement causes the hollow needle 19 to pierce both adjacent diaphragms 9, 27, thereby establishing a fluid connection between the through-flow fluid channel 5 and the hollow needle 19. The movement of the second coupling adapter part 13 during the second movement window ends with the locking arms 21 engaging in the undercuts 11 and 16 of the two coupling adapter parts 3, 13.As explained above, the hollow needle is held at its proximal end by the anchor sleeve 20, which also serves as a connection / connector for, for example, a syringe, and whose interior is in fluid communication with the fluid channel 5 of the first coupling adapter part 3 via the hollow needle 19.

[0013] The separation / disconnection of both coupling adapter parts 3, 13 takes place in exactly the reverse order, whereby after disengaging the locking arms 21 by means of a push button, the hollow needle 19 is first pulled out of the two membranes 9, 27 by moving the second coupling adapter part 13 away from the first coupling adapter part 3 (i.e. according to the aforementioned second movement time window) and subsequently (i.e. according to the aforementioned first movement time window) the two membranes 9, 27 are lifted apart from each other, without any liquid being able to drip from either the syringe or the vial / fluid line system.

[0014] Typically, one end of the dry break is connected to a syringe via a Luer-lock fitting. A Luer-lock fitting is a standardized conical connection with an optional male or female thread (male or female coupling part). It is described in the ISO 80369-7 standard and is generally used for infusion products to standardize connection types.

[0015] The syringe typically has a ma / e Luer coupling, so the Dry Break has a fema / e Luer coupling, i.e., a fema / e Luer connector, which is intended to connect to the syringe. A Luer lock connection is a so-called open connection; it is therefore not dry. Because the Dry Break is meant to provide a dry connection to the CSTD system, but the Luer connection to the Dry Break is not dry, it is advisable to equip the Luer connection with a free-running or rotating mechanism. This allows the syringe to be connected to the Luer connector only once and then not disconnected again. As a result, the Luer connection becomes dry due to the permanently engaged free-running mechanism.Document EP 3415 136 A2 discloses a Luer connection with a freewheel rotation mechanism, in which the Luer connector 47 is received in a housing such that a connection is secured against rotation in the screw-in direction of the Luer thread. Furthermore, the connection between the housing 25 and the Luer connector 47 is designed such that when the Luer connector is rotated in the opposite direction, a freewheel or ratchet mechanism is engaged, allowing the Luer connector to rotate freely in this opposite direction.

[0016] Nevertheless, for some applications, such as in emergency situations, it is necessary that the connection to the dry break can be disconnected. This is made possible by the fact that the Luer connector is no longer rotatable. Therefore, currently, dry break products with a fixed Luer connector, from which the syringe can be disconnected, and dry break products with a freely rotatable Luer connector, from which the syringe cannot be removed, are available on the market.

[0017] Thus, a disadvantage is that two different products have to be manufactured, one with a rotationally fixed Luer connector and one with a rotatable Luer connector, which leads to additional production costs and results in the life cycle of the components not being used efficiently.

[0018] Furthermore, the user of these products has to buy and keep in stock two different products, which brings further economic disadvantages.

[0019] Finally, a safety issue also arises. When selecting a product for a specific application, the user must be certain that they have chosen the correct product, and replacing an incorrectly chosen product poses a safety risk. The invention therefore aims to create a Luer connection that reduces production and operating costs while minimizing operational safety risks.

[0020] This problem is solved with a Luer connection having the features of claim 1 and with a Luer connector having the features of claim 13.

[0021] The Luer connection is designed such that the Luer connector is attached to the first component in such a way that, in an initial operating state, it is rotationally fixed to the first component. After applying a predetermined limit torque, it can be moved into a second operating state in which it is freely rotatable relative to the first component in at least one direction opposite to the thread direction of the detachable screw connection, and preferably in both directions. This results in a Luer connection with an initially locked free movement, allowing the second component, such as a syringe, to be mounted and dismounted via the Luer screw connection by applying ordinary torque.With a simple adjustment, namely by applying a specific, higher torque to the Luer connector, the Luer connection can be switched to a state in which the Luer connector is locked, preventing the removal of a syringe. The limiting torque is, of course, set so that it can be easily applied by the operator.

[0022] The freewheel does not need to be designed to allow free rotation in both directions. Therefore, a configuration can also be used in which the Luer connector interacts with the first component via a ramp / lock arrangement. When a syringe is connected to the Luer connector, the latter cannot rotate in the direction of the screw thread due to the locks. Conversely, when the Luer connector is rotated against the direction of the screw thread, flat sides of the ramps slide over the locks, preventing torque transmission. Thanks to the inventive design of the Luer connection, a single Luer connector is sufficient to ensure both operating states, thus completely solving the aforementioned problem.

[0023] The conversion of the function of the Luer connector, which is identical for both operating states, can be achieved in a variety of ways. A particularly simple design in terms of production and tooling is the subject of claim 2. To move the Luer connector from the first operating state to the second operating state, it is sufficient to apply a predetermined torque sufficient to break the material and / or substance and / or form fit. An advantage of this is that the forces required can be small, so that the points where a rotary locking mechanism of the Luer connector is implemented can be designed with a small volume, thus eliminating the need for additional installation space.

[0024] An advantageous positive-locking anti-rotation device in the first operating state is achieved with the features of claim 3. An advantageously designed Luer connector for this variant of the Luer connection is the subject of claim 13, according to which at least one locking element, preferably made of plastic, is located in a receiving opening in the first component between the latter and the Luer connector, and which fixes the Luer connector rotationally fixed with respect to the receiving opening and can be sheared off by applying the limiting torque. By means of the locking element, which has a small cross-section of only a few mm² 2 Because the locking mechanism can be designed in such a way that the limit torque can be precisely defined, thus preventing operating errors. Shearing can be achieved within the locking element or at the connection point, for example, an adhesive joint, to the first component and / or at the Luer connector.

[0025] If the fragment of the locking element produced during shearing remains trapped in the Luer connector or the first component, it cannot escape into the surrounding area and potentially cause damage, which further enhances operational safety. According to an advantageous embodiment, the Luer connector has a circular cylindrical main part that is received with a clearance fit in a cup-shaped receptacle of the first component, and the locking element is formed by a rod-shaped body that projects from a radial shoulder of the receptacle and engages positively in an axial groove of the circular cylindrical main part of the Luer connector. Although it is fundamentally possible to reverse the kinematic configuration and attach or form the locking element on the Luer connector, this further development results in a particularly simple design of the Luer connector.

[0026] The rod-shaped body can be a separate component that engages with corresponding recesses in the first component and / or the Luer connector. If the rod-shaped body is integrally connected to the first component, assembly is advantageously simplified. This design is particularly suitable when the components of the Luer connection are injection-molded plastic parts.

[0027] Alternatively, it is also possible to glue or weld the rod-shaped body to the first component or to the Luer connector.

[0028] Instead of or in addition to the positive-locking anti-rotation device for the Luer connector described above, the Luer connection can be designed, according to one variant, such that the Luer connector, with a circular cylindrical main part featuring a clearance fit, is received in a cup-shaped receptacle of the first component and has at least one material- and / or chemically bonded connection point in this receptacle, which can be irreversibly released by applying the limiting torque. It has been found that a single connection point with an area in mm² is sufficient. 2 -area to implement a rotation lock for the Luer connector, which significantly simplifies the assembly of the Luer connector.

[0029] Preferably, the material- and / or chemically bonded connection of the Luer connector to the first component is achieved using a technique from the group consisting of bonding with solvent-based adhesives, UV bonding, ultrasonic welding, laser welding, hot bonding, and crimping or flaring techniques. All these techniques require only minimal intervention in the shape of the Luer connector or the first component and require little effort in producing the Luer connection.

[0030] The Luer connection can be used for a wide variety of products, although it offers particular advantages in conjunction with infusion products. A particularly advantageous application of the Luer connection arises when the first component is part of a Closed System Transfer Device (CSTD), especially when formed by a male dry break. The application is not limited to the use of a syringe as the second component. The Luer connection can be used for any male / female Luer coupling. A male Luer connector (according to ISO 80369-7) can also be used instead of a female Luer connector. Furthermore, the Luer connection can be used for male and female conical connections for tube feeding according to ISO 80369-3 and for neuraxial applications in spinal anesthesia according to ISO 80369-6.

[0031] A Luer connector advantageously designed for both operating states of the Luer connection described above is the subject of claims 13 to 15. It differs from a conventional Luer connector essentially in that the central main body is equipped on its radial shoulder with a recess designed for the preferably positive engagement of a locking element fixed in the medical device.

[0032] Exemplary embodiments of the invention are explained in more detail below with reference to schematic drawings. These show:

[0033] Figures 1A, 1B and 2 show a CSTD system of known construction and function; Figures 3 and 4 show top views of a male dry break with an inserted Luer connector according to the invention, rotated by 90°; Figures 5 and 6 show sectional views according to AA in Figure 4 and BB in Figure 3; Figures 7 and 8 show sectional views according to DD and CC in Figure 3;

[0034] Figure 9 shows a perspective view of the components of the Luer connection according to the invention; and

[0035] Figure 10 shows a partial sectional view of a modified Luer connector as part of the Luer connection according to the invention.

[0036] Figures 3 to 9 show a Luer connection of a CSTD system between a male dry break 13 and a female Luer connector 20, which is coaxially coupled to the male dry break 13 to establish a connection to a fluid transfer component, such as a syringe. The male dry break 13 is essentially identical in construction to the male dry break 13 shown in Figures 1 and 2. In general, the Luer connection thus lies between a first component of a medical fluid piping system—in this case, a CSTD component 13 with a dry break coupling—and a second (not shown) component, such as a syringe, which can be connected to the first component, i.e., the male dry break 13, via a detachable screw connection (Luer threaded connection) and a Luer connector 20, in this case a female Luer connector.

[0037] The Luer connector 20 with axis 20A has – as can best be seen from the sectional views according to Figures 5 and 6 and Figure 9 – a hollow cylindrical shape with three sections: a central, essentially circular cylindrical main body 30, which is prepared for preferably precise insertion into a mounting recess 80 of the Male Dry Break 13; a first hollow cylindrical extension 50, which extends away from the central main body 30 in a first axial direction and forms a Luer thread 52; and a second hollow cylindrical extension 40, which extends away from a radial shoulder 32 of the central main body 30 in the second axial direction and has a snap collar 70 on its end face, which is prepared to secure the Luer connector 20 against being pulled out in an axial mounting stop position shown in Figures 3 to 6.In this position, the snap fastener 70 interacts with at least one spring-loaded snap tongue 66 in the housing 15 of the medical device, configured as a male dry break 13, such that the Luer connector 20 is secured against being pulled out. The Luer connector 20 is thus in a first operating state, in which it is possible to connect a syringe via the Luer screw connection.

[0038] To save weight, the main body 30 of the Luer connector 20—as best seen in Figure 9—has the form of a hollow cylinder with a plurality of radial recesses 31 between the end surfaces. The radial shoulder 32 carries a preferably diametrically extending rib 34 (see also Figure 8), which provides an axial stop for the Luer connector 20 in the mounting recess 80. More precisely, in the illustrated mounting position of the Luer connector 20, the rib 34, which can also be referred to as a stiffening rib, rests against a ring- and cross-shaped projection configuration 36 on a bottom surface 82 of the mounting recess 80, which is designed as a radial shoulder.

[0039] In order for a syringe or the like to be screwed onto the Luer connector 20, the Luer connector 20 must be locked against rotation in the thread direction of the Luer screw connection in the first operating state shown. For this purpose, the central main body 30 is equipped on its radial shoulder 32 with a groove-like recess 38, which is designed for the positive engagement of a locking element 86 fixed against rotation in the medical device, i.e., in the male dry break 13. The locking element 86 is preferably made of plastic and, in this case, is preferably injection-molded onto the base surface 82. However, the connection can also be made in another way, for example by a weld or adhesive bond. A plug connection is also possible.

[0040] Crucially, the stability of the locking element 86 and / or its adhesive strength on the housing 15 of the Male Dry Break 13 must be sufficient to ensure that the Luer connector 20 remains undamaged when the syringe is screwed on and off, thus maintaining the first operating state of the Luer connector 20. Conversely, the stability of the locking element 86 and / or its adhesive strength on the housing 15 of the Male Dry Break 13 must be such that applying a predetermined limit torque to the Luer connector 20 releases its locking effect, allowing the Luer connector 20 to enter a second operating state in which it is freely rotatable relative to the housing 15 of the Male Dry Break 13. In this second operating state, the Luer screw connection to the syringe can no longer be loosened.

[0041] The embodiment shown in Figures 3 to 9 is designed such that the Luer connector 20 is rotationally fixed in the male dry break 13 by positive locking in its initial operating state, and that this positive locking can be broken by applying the limiting torque, thereby allowing the Luer connector 20 to be moved into its second operating state. In this process, the locking element 86, which fits snugly into the groove-like recess 38, is sheared off. The arrangement is such that the fragment of the locking element 86 produced during shearing remains trapped in the Luer connector 20 or – in the case of an arrangement with kinematic reversal – in the housing 15 of the male dry break 13.

[0042] From the above description, it follows that with a single Luer connector 20 it is possible to represent two operating states of the Luer connection, thereby creating a Luer connection with which it is possible to reduce production and operating costs with minimal operational safety risk.

[0043] As an alternative to the embodiment described above, the functionality of the Luer connection can also be converted using a single Luer connector in another way. The Luer connector 20 shown in Figure 9 can still be accommodated with a circular cylindrical main part 30 with a clearance fit in a cup-shaped mounting recess 80 of the male dry break 13.

[0044] Instead of or in addition to the groove-like recess 38, the Luer connector 20 has at least one material- and / or substance-locking connection point in this mounting recess 80, marked by arrows AS in Figure 9, which can be irreversibly released by applying the limit torque.

[0045] The components of a CSTD system are generally made of plastic. Therefore, it is advantageous if the material- and / or chemically bonded connection of the Luer connector 20 to the male dry break 13 is achieved using a technique from the group of solvent-based adhesive bonding, UV bonding, ultrasonic welding, laser welding, hot bonding, and crimping or flaring techniques.

[0046] Of course, deviations from the described design are possible without abandoning the basic idea of ​​the invention:

[0047] The above describes a Luer connection where the first component, the Male Dry Break 13, is part of a Closed System Transfer Device (CSTD). However, it should be emphasized that its application is not limited to this. Nor is it limited to the use of a syringe as the second component. The Luer connection can be used for any male / female Luer coupling. A male Luer connector (according to ISO 80369-7) can also be used instead of a female Luer connector. Furthermore, the Luer connection can be used for male and female conical connections for tube feeding according to ISO 80369-3 and for neuraxial applications in spinal anesthesia according to ISO 80369-6.

[0048] Even though the described Luer connection is designed for the administration of infusion products, the Luer connector 20, which can also be designed as a male Luer connector 120 (as indicated in Figure 10) with a modified Luer thread 152, can also be used for other substances.

[0049] The freewheel of the Luer connector need not be a complete freewheel. A so-called directional freewheel can also be provided, in which the Luer connector interacts with the first component via a ramp / lock arrangement. This prevents the Luer connector from rotating in the direction of the thread when a syringe is connected to it, due to the locks. Conversely, when the Luer connector is rotated against the thread direction, flat sides of the ramps slide over the locks, preventing any torque transmission.

[0050] Instead of a locking element 86 attached to the Luer connector 20 or to the housing 15, a separate component can also be used, which is positioned between two contact surfaces of the Luer connector and the housing in such a way that it engages with both components.

[0051] The invention thus provides a Luer connection between a first component of a medical fluid piping system, in particular a CSTD component with a dry-break coupling, and a second component, such as a syringe, which can be connected to the first component via a Luer connector using a detachable screw connection. To create a Luer connection that reduces production and operating costs while minimizing operational safety risks, the Luer connector is attached to the first component in such a way that, in an initial operating state, it is rotationally fixed to the first component. After applying a predetermined limit torque, it can be moved into a second operating state in which it is freely rotatable relative to the first component in at least one direction opposite to the thread direction of the detachable screw connection, preferably in both directions.

[0052] Reference symbol list

[0053] 1 CSTD system

[0054] 3, 3* first coupling adapter part (Female Dry Break)

[0055] 4 cases

[0056] 5 Fluid channel component

[0057] 6 (Luer Lock) coupling

[0058] 7 proximal flange side membrane

[0059] Cheeks as guide surfaces in 4

[0060] Undercuts

[0061] Inner side walls, second coupling adapter part (Male Dry Break)

[0062] Housing

[0063] Undercuts

[0064] Pistons

[0065] Opening in 15

[0066] Hollow needle * Anchor sleeve

[0067] Luer connector A axis

[0068] Locking arms

[0069] (central) through channel

[0070] Coupling or flange side 25 of the second coupling adapter part 13

[0071] Membrane central main body radial recesses

[0072] radial shoulder

[0073] rib

[0074] Protrusion configuration second process first process

[0075] Luer thread (external thread)

[0076] Snapping tongue

[0077] Snap fastener

[0078] Mounting recess

[0079] Ground surface as radial shoulder

[0080] Locking element 0 male Luer connector 0 first extension

Claims

Claims 1. Luer connection between a first component (13, 15) of a medical fluid piping system, in particular a CSTD component with dry-break coupling, and a second component, such as a syringe, which can be connected to the first component (13) via a detachable screw connection (52; 152) and a Luer connector (20; 120), characterized in that the Luer connector (20) is attached to the first component (13, 15) in such a way that it is rotatably connected to the first component (13, 15) in an initial first operating state and can be brought into a second operating state after the application of a predetermined limit torque, in which it is freely rotatable relative to the first component (13, 15) in at least one direction opposite to the thread direction of the detachable screw connection, preferably in both directions of rotation.

2. Luer connection according to claim 1, characterized in that the Luer connector (20) is rotationally fixed in the first component (13, 15) in the initial first operating state by material and / or substance and / or form locking, and that the material and / or substance and / or form locking can be destroyed by applying the limiting torque, whereby the Luer connector (20) can be brought into the second operating state.

3. Luer connection according to claim 2, characterized in that in a receiving opening (80) in the first component (13, 15) between the latter and the Luer connector (20) there is at least one locking element (86) which fixes the Luer connector (20) rotationally fixed with respect to the receiving opening and which can be sheared off by applying the limit torque.

4. Luer connection according to claim 3, characterized in that the fragment of the locking element (86) produced during shearing remains trapped in the Luer connector (20) or in the first component (13, 15).

5. Luer connection according to claim 3 or 4, characterized in that the Luer connector (20) is received with a circular cylindrical main part (30) with clearance fit in a cup-shaped receptacle (80) of the first component (13, 15), and the locking element (86) is formed by a rod-shaped body which projects from a radial shoulder (82) of the receptacle (80) and engages positively in an axial groove (38) of the circular cylindrical main part (30).

6. Luer connection according to claim 5, characterized in that the rod-shaped body (86) is integrally connected to the first component (13, 15).

7. Luer connection according to claim 5, characterized in that the rod-shaped body (86) is bonded or welded to the first component (13, 15).

8. Luer connection according to claim 1 or 2, characterized in that the Luer connector (20) is received with a circular cylindrical main part (30) with clearance fit in a cup-shaped receptacle (80) of the first component (13, 15) and has in this receptacle (80) at least one material- and / or substance-bonded connection point (AS) which can be irreversibly released by applying the limit torque.

9. Luer connection according to claim 8, characterized in that the material- and / or substance-locking connection of the Luer connector (20) to the first component (13, 15) is produced by a technique from the group consisting of bonding with solvent-based adhesives, UV bonding, ultrasonic welding, laser welding, hot bonding and crimping or flanging techniques.

10. Luer connection according to one of claims 1 to 9, characterized in that the first component (13, 15) is part of a “Closed System Transfer Device” (CSTD), in particular formed by a Male Dry Break (13).

11. Luer connection according to one of claims 1 to 10, characterized in that the Luer connector (20) is designed for the administration of infusion products.

12. Luer connection according to claim 11, characterized in that the Luer connector (20; 120) is configured as a male or female Luer connector.

13. Luer connector (20; 120) for a Luer connection according to one of claims 1 to 12, comprising a central, substantially circular cylindrical main body (30) which is preferably designed for precise fit in a mounting recess (80) of a medical device (13), in particular a CSTD system, a first hollow cylindrical extension (50) which extends away from the central main body (30) in a first axial direction and forms a Luer thread (52), and a second hollow cylindrical extension (40) which extends away from a radial shoulder (32) of the central main body (30) in the second axial direction and has a snap collar (70) on its end face, which secures the Luer connector (20) against being pulled out in an axial mounting stop position for interaction with at least one snap tongue (66) in the housing (15) of the medical device (13) is preparedwherein the central main body (30) is provided on its radial shoulder (32) with a recess (38) which is designed for the preferably positive engagement of a locking element (86) fixed in the medical device (13) in a rotationally fixed manner.

14. Luer connector (20; 120) according to claim 13, characterized in that the central main body (30) has the form of a hollow cylinder with several radial recesses (31) between its end faces.

15. Luer connector (20; 120) according to claim 13 or 14, characterized in that the central main body (30) has a second hollow cylindrical extension (40) facing end surface has a radial stiffening rib (34) to form an axial stop with a base surface (82, 36) of the mounting recess (80).

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