Method and apparatus for determining irradiation parameter, and radiation therapy system

Abstract

The present application relates to a method and apparatus for determining an irradiation parameter, and a radiation therapy system. The apparatus comprises: a parameter preset module, configured to determine an initial irradiation center point and an initial irradiation angle on the basis of a first positional relationship between a target irradiation area and an irradiation object; and a parameter screening module, configured to enable a second positional relationship between the target irradiation region and a radiation outlet to satisfy a first preset radiation condition to give a first irradiation position, and further configured to determine whether a third positional relationship between the irradiation object and the radiation outlet satisfies a second preset radiation condition, and if yes, to use the initial irradiation center point and the initial irradiation angle as irradiation parameters, or if no, to increase a source-skin distance and determine whether a preset distance condition is satisfied. According to the present invention, the irradiation parameters are quickly determined on the basis of the first preset radiation condition, the second preset radiation condition, and the preset distance condition of the source-skin distance without considering complex dose calculation, thereby saving the calculation time.

Description

Radiation irradiation parameter determination method and device and radiation treatment system TECHNICAL FIELD

[0001] The present application relates to the technical field of nuclear physics, and relates to a radiation treatment system, in particular to a radiation irradiation parameter determination device and method. BACKGROUND

[0002] Radiation irradiation refers to the irradiation process of radiation (such as X-ray, gamma ray or neutron ray) on an object or a human body. Radiation irradiation has wide applications in the fields of medicine, industry and scientific research.

[0003] Radiation irradiation is applied to the medical field, that is, to radiotherapy. In the process of radiotherapy, a beam needs to be used to continuously irradiate a patient for a certain time. Before irradiation, a suitable incident angle needs to be selected to ensure that the radiation line can kill tumor cells in the patient's body to the maximum extent and reduce damage to the surrounding normal tissues as much as possible. For photon therapy, electron therapy, proton therapy and heavy particle therapy, the patient position is fixed, and a treatment is performed by rotating and adjusting the outlet of the radiation source to perform treatment at any and several incident angles. For neutron capture therapy, the neutron beam position is fixed, and the irradiation angle of the treatment plan needs to be realized by patient positioning. SUMMARY

[0004] In some radiation irradiation schemes, the irradiation time is long, and the number of irradiation fields is small. Since the particle migration simulation operation process is complicated and time-consuming, the selection of irradiation parameters also needs to consider the optimization of dose distribution, and the entire operation process is very time-consuming.

[0005] Therefore, it is necessary to provide a radiation irradiation parameter determination method, device and radiation treatment system capable of quickly determining irradiation parameters in view of the above technical problems.

[0006] In a first aspect, the present application provides a radiation irradiation parameter determination device, comprising: a parameter preset module, configured to determine an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object; the target irradiation region is a part of the irradiation object, and the radiation is generated by a radiation source; the target irradiation region is located in an effective irradiation field of a radiation outlet; a parameter screening module, configured to translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, so that a second positional relationship between the target irradiation region and the radiation outlet meets a first preset radiation condition, to obtain a first irradiation position; the parameter screening module is further configured to obtain a third positional relationship between the irradiation object and the radiation outlet under the first irradiation position; if the third positional relationship between the irradiation object and the radiation outlet meets a second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

[0007] In one of the embodiments, the parameter preset module is further configured to: determine a longest diameter of the target irradiation region; determine a shortest distance between a plane where the longest diameter is located and a surface of the irradiation object; take an intersection point between the straight line where the shortest distance is located and the surface of the irradiation object as the initial irradiation center point; and take an irradiation angle that meets the condition that the straight line where the shortest distance is located coincides with the initial irradiation center point and a center point of the radiation source as the initial irradiation angle.

[0008] In one of the embodiments, the parameter screening module is further configured to: determine a pre-protection region of the irradiation object; translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, to obtain a plurality of alternative irradiation positions in the case that the second positional relationship between the target irradiation region and the radiation outlet meets the first preset radiation condition; and obtain a plurality of projection areas of the pre-protection region in the effective irradiation field of the radiation outlet along the initial irradiation angle direction in the plurality of alternative irradiation positions, to take an alternative irradiation position with the minimum projection area as the first irradiation position.

[0009] In one of the embodiments, the first preset radiation condition comprises that the target irradiation region is located in the effective irradiation field of the radiation outlet, and an edge of the target irradiation region is greater than or equal to a preset distance threshold from an edge of the radiation outlet.

[0010] In one of the embodiments, the second preset radiation condition comprises that the irradiation object does not interfere with the radiation outlet.

[0011] In one of the embodiments, the parameter screening module is further configured to: if the third positional relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, increase the source-skin distance between the radiation outlet and the irradiation object until the third positional relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, determine whether the source-skin distance satisfies a preset distance condition; and if the source-skin distance satisfies the preset distance condition, take the initial irradiation center point and the initial irradiation angle as the radiation irradiation parameters.

[0012] In one of the embodiments, the parameter screening module is further configured to: if the source-skin distance does not satisfy the preset distance condition, keep the initial irradiation center point unchanged, change the initial irradiation angle within a preset angle range to obtain a plurality of reference irradiation angles; for each reference irradiation angle, translate the initial irradiation center point under the condition that the reference irradiation angle is fixed to make the second positional relationship between the target irradiation region and the radiation outlet satisfy the first preset radiation condition to obtain a plurality of reference irradiation positions, determine whether the third positional relationship between the irradiation object and the radiation outlet under each reference irradiation position satisfies the second preset radiation condition, if the third positional relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, take the initial irradiation center point and the reference irradiation angle as the radiation irradiation reference parameters; if the third positional relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, increase the source-skin distance between the radiation outlet and the irradiation object until the third positional relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, determine whether the source-skin distance between the radiation outlet and the irradiation object satisfies the preset distance condition; if the source-skin distance satisfies the preset distance condition, take the initial irradiation center point and the reference irradiation angle as the radiation irradiation reference parameters; and determine the farthest distance between the target irradiation region and the radiation outlet in each reference parameter, and take the reference parameter with the minimum farthest distance as the radiation irradiation parameter.

[0013] In one of the embodiments, the changing of the initial irradiation angle within the preset angle range specifically comprises: establishing an X-Y-Z three-dimensional coordinate with the center point of the radiation source as the origin, and the radiation outlet direction as the X axis, and the shortest distance deviates from the X axis by an angle θ around the initial irradiation center point in the X-Y plane, or the shortest distance deviates from the X axis by an angle Φ around the initial irradiation center point in the X-Z plane.

[0014] In one of the embodiments, the parameter preset module is further configured to: re-determine a second initial irradiation center point and a second initial irradiation angle; specifically, if the source-skin distance of the radiation outlet and the irradiation object at each of the reference irradiation positions does not satisfy the preset distance condition, it is determined that the current initial irradiation center point does not meet the radiation irradiation requirement; the current initial irradiation center point and the initial irradiation angle are excluded, and the second initial irradiation center point and the second initial irradiation angle are determined based on the target irradiation region and the fourth positional relationship of the irradiation object.

[0015] In one of the embodiments, the re-determination of the second initial irradiation center point and the second initial irradiation angle based on the target irradiation region and the fourth positional relationship of the irradiation object comprises: excluding the tangent plane of the longest diameter of the target irradiation region and the tangent plane within the angle of -α to +α of the longest diameter; defining the longest diameter of the remaining part of the target irradiation region as a second longest diameter, and defining the shortest distance between the plane where the second longest diameter is located and the surface of the irradiation object as a second shortest distance; taking the intersection point between the straight line where the second shortest distance is located and the surface of the irradiation object as the second initial irradiation center point, and taking the straight line where the second shortest distance is located as the second initial irradiation angle.

[0016] In one of the embodiments, the angle α is 5 degrees.

[0017] In a second aspect, the present application further provides a method for determining radiation irradiation parameters, which comprises: determining an initial irradiation center point and an initial irradiation angle based on a first positional relationship of a target irradiation region and an irradiation object; the target irradiation region is a part of the irradiation object, and the radiation is generated by a radiation source; the target irradiation region is located in the effective irradiation field of a radiation outlet; the initial irradiation center point is translated under the condition of fixing the initial irradiation angle, so that a second positional relationship between the target irradiation region and the radiation outlet satisfies a first preset radiation condition, to obtain a first irradiation position; a third positional relationship between the irradiation object and the radiation outlet at the first irradiation position is obtained; and if the third positional relationship between the irradiation object and the radiation outlet satisfies a second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

[0018] In one of the embodiments, the determination of the initial irradiation center point and the initial irradiation angle based on the first positional relationship of the target irradiation region and the irradiation object comprises: determining the longest diameter of the target irradiation region; determining the shortest distance between the plane where the longest diameter is located and the surface of the irradiation object; taking the intersection point between the straight line where the shortest distance is located and the surface of the irradiation object as the initial irradiation center point, and taking the irradiation angle that satisfies the coincidence of the straight line where the shortest distance is located with the initial irradiation center point and the center point of the radiation source as the initial irradiation angle.

[0019] In one of the embodiments, the method further comprises: determining a pre-protection area of the irradiation object; translating the initial irradiation center point under the condition of fixing the initial irradiation angle to obtain a plurality of candidate irradiation positions, in which the second positional relationship between the target irradiation area and the radiation outlet satisfies the first preset radiation condition; and obtaining a plurality of projection areas of the pre-protection area in the effective irradiation field of the radiation outlet along the initial irradiation angle direction in the plurality of candidate irradiation positions, and taking the candidate irradiation position with the minimum projection area as the first irradiation position.

[0020] In one of the embodiments, the first preset radiation condition comprises: the target irradiation area is located in the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation area and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

[0021] In one of the embodiments, the second preset radiation condition comprises: the irradiation object does not interfere with the radiation outlet.

[0022] In one of the embodiments, the method further comprises: if the third positional relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, increasing the source-skin distance between the radiation outlet and the irradiation object to a third positional relationship between the surface of the irradiation object and the radiation outlet that satisfies the second preset radiation condition, determining whether the source-skin distance satisfies a preset distance condition; and if the source-skin distance satisfies the preset distance condition, taking the initial irradiation center point and the initial irradiation angle as the radiation irradiation parameters.

[0023] In one of the embodiments, the method further comprises: if the source-skin distance does not satisfy the preset distance condition, keeping the initial irradiation center point unchanged, changing the initial irradiation angle within a preset angle range to obtain a plurality of reference irradiation angles; for each reference irradiation angle, under the condition of fixing the reference irradiation angle, translating the initial irradiation center point to make the second positional relationship between the target irradiation region and the radiation outlet satisfy the first preset radiation condition to obtain a plurality of reference irradiation positions, judging whether the third positional relationship between the irradiation object and the radiation outlet under each reference irradiation position satisfies the second preset radiation condition, if the third positional relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, taking the initial irradiation center point and the reference irradiation angle as the radiation irradiation reference parameters; if the third positional relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, increasing the source-skin distance between the radiation outlet and the irradiation object to the third positional relationship between the irradiation object and the radiation outlet satisfying the second preset radiation condition, judging whether the source-skin distance between the radiation outlet and the irradiation object satisfies the preset distance condition; if the preset distance condition is satisfied, taking the initial irradiation center point and the reference irradiation angle as the radiation irradiation reference parameters; determining the farthest distance between the target irradiation region and the radiation outlet in each reference parameter, and taking the reference parameter with the minimum farthest distance as the radiation irradiation parameter.

[0024] In one of the embodiments, the process of changing the initial irradiation angle within a preset angle range comprises: establishing an X-Y-Z three-dimensional coordinate with the center point of the radiation source as the origin, and the radiation exit direction as the X axis, and the shortest distance deviates from the X axis by an angle θ around the initial irradiation center point in the X-Y plane, or the shortest distance deviates from the X axis by an angle Φ around the initial irradiation center point in the X-Z plane.

[0025] In one of the embodiments, the method further comprises: re-determining a second initial irradiation center point and a second initial irradiation angle.

[0026] Specifically, if the source-skin distance between the radiation outlet and the irradiation object under each reference irradiation position does not satisfy the preset distance condition, it is determined that the current initial irradiation center point does not meet the radiation irradiation requirement; the current initial irradiation center point and the initial irradiation angle are excluded, and a second initial irradiation center point and a second initial irradiation angle are determined based on the fourth positional relationship between the target irradiation region and the irradiation object.

[0027] In one of the embodiments, the fourth position relationship between the target irradiation region and the irradiation object is used to re-determine the second initial irradiation center point and the second initial irradiation angle, which includes: excluding the tangent of the longest diameter of the target irradiation region and the tangent within the angle of -a~+a; defining the longest diameter of the remaining part of the target irradiation region as a second longest diameter, and the shortest distance between the plane of the second longest diameter and the surface of the irradiation object as a second shortest distance; taking the intersection point between the line direction of the second shortest distance and the surface of the irradiation object as the second initial irradiation center point, and taking the irradiation angle that satisfies the coincidence of the line of the second shortest distance, the second initial irradiation center point and the center point of the radiation source as the second initial irradiation angle.

[0028] In one of the embodiments, the angle a is 5 degrees.

[0029] In a third aspect, the present application further provides a radiotherapy system, which comprises: a placing device for supporting an irradiation object; a radiation generation device comprising a radiation source and a radiation outlet; the radiation source generates radiation, and the radiation generated by the radiation source is emitted from the radiation outlet and irradiates the irradiation object; and a radiation irradiation parameter determination device, which comprises: a parameter preset module for determining an initial irradiation center point and an initial irradiation angle based on a first position relationship between a target irradiation region and the irradiation object; the target irradiation region is a part of the irradiation object, and the radiation is generated by the radiation source; the target irradiation region is located within the effective irradiation field of the radiation outlet; a parameter screening module for translating the initial irradiation center point under the condition of fixing the initial irradiation angle, so that a second position relationship between the target irradiation region and the radiation outlet satisfies a first preset radiation condition, to obtain a first irradiation position; the parameter screening module is further used to obtain a third position relationship between the irradiation object and the radiation outlet under the first irradiation position; and if the third position relationship between the irradiation object and the radiation outlet satisfies a second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

[0030] In one of the embodiments, the first preset radiation condition includes that the target irradiation region is located within the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation region and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

[0031] In one of the embodiments, the second preset radiation condition includes that the irradiation object does not interfere with the radiation outlet.

[0032] In a fourth aspect, the present application provides a computer device comprising a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement the following steps: determining an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, wherein the target irradiation region is a part of the irradiation object, the radiation is generated by a radiation source, and the target irradiation region is located within an effective irradiation field of a radiation outlet; translating the initial irradiation center point under the condition of fixing the initial irradiation angle to make a second positional relationship between the target irradiation region and the radiation outlet meet a first preset radiation condition, to obtain a first irradiation position; obtaining a third positional relationship between the irradiation object and the radiation outlet at the first irradiation position; and if the third positional relationship between the irradiation object and the radiation outlet meets a second preset radiation condition, taking the initial irradiation center point and the initial irradiation angle as radiation irradiation parameters.

[0033] In a fifth aspect, the present application provides a computer readable storage medium having a computer program stored thereon, wherein the computer program is executed by a processor to implement the following steps: determining an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, wherein the target irradiation region is a part of the irradiation object, the radiation is generated by a radiation source, and the target irradiation region is located within an effective irradiation field of a radiation outlet; translating the initial irradiation center point under the condition of fixing the initial irradiation angle to make a second positional relationship between the target irradiation region and the radiation outlet meet a first preset radiation condition, to obtain a first irradiation position; obtaining a third positional relationship between the irradiation object and the radiation outlet at the first irradiation position; and if the third positional relationship between the irradiation object and the radiation outlet meets a second preset radiation condition, taking the initial irradiation center point and the initial irradiation angle as radiation irradiation parameters.

[0034] In a sixth aspect, the present application provides a computer program product comprising a computer program which, when executed by a processor, implements the following steps: determining an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, the target irradiation region being a part of the irradiation object, the radiation being generated by a radiation source, the target irradiation region being located within an effective irradiation field of a radiation outlet; translating the initial irradiation center point under the condition of fixing the initial irradiation angle to make a second positional relationship between the target irradiation region and the radiation outlet meet a first preset radiation condition, to obtain a first irradiation position; obtaining a third positional relationship between the irradiation object and the radiation outlet at the first irradiation position; and taking the initial irradiation center point and the initial irradiation angle as radiation irradiation parameters if the third positional relationship between the irradiation object and the radiation outlet meets a second preset radiation condition.

[0035] The above-mentioned radiation irradiation parameter determination method, device, computer equipment and storage medium, in the radiation irradiation parameter determination method, first, based on a first positional relationship between a target irradiation region and an irradiation object, an initial irradiation center point and an initial irradiation angle are determined; the initial irradiation center point is translated under the condition of fixing the initial irradiation angle, and a first preset radiation condition, a second preset radiation condition and a preset distance condition of source-skin distance are judged to obtain radiation irradiation parameters meeting irradiation requirements. By setting the first preset radiation condition, it is ensured that the target irradiation region is located within the effective irradiation field range, and the dose received by the pre-protection region is reduced; the second preset radiation condition is set to facilitate the positioning adjustment of the irradiation object; the source-skin distance is limited to meet the preset distance condition to ensure the irradiation treatment effect. The present application also provides that the irradiation center is determined according to the longest diameter of the target irradiation region, and the irradiation angle deflection can be set within a certain angle range to screen the irradiation scheme, effectively reducing the irradiation angle screening calculation time. BRIEF DESCRIPTION OF DRAWINGS

[0036] In order to more clearly illustrate the technical solutions in the embodiments or the related art, the following will briefly introduce the drawings needed to be used in the embodiments or the related art description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without any creative effort.

[0037] FIG. 1 is a flowchart of a radiation irradiation parameter determination method in an embodiment;

[0038]

[0038] FIG. 2 is a schematic diagram of the positional relationship between a radiation outlet, an irradiation object and a target irradiation object in an embodiment;

[0039] FIG. 3 is a flowchart of moving an initial position to obtain a target position in an embodiment;

[0040] FIG. 4 is a flowchart of a method for determining a radiation irradiation parameter in a case where a current distance does not satisfy a preset distance condition, according to an embodiment of the present disclosure;

[0041] FIG. 5 is a flowchart of a method for determining a second initial irradiation angle, according to an embodiment of the present disclosure;

[0042] FIG. 6A is a flowchart of a method for determining a radiation irradiation parameter, according to another embodiment of the present disclosure;

[0043] FIG. 6B is a flowchart of a method for determining a radiation irradiation parameter, according to another embodiment of the present disclosure;

[0044] FIG. 7 is a block diagram of a radiation irradiation parameter determination apparatus, according to an embodiment of the present disclosure;

[0045] FIG. 8 is a block diagram of a radiation therapy system, according to an embodiment of the present disclosure;

[0046] FIG. 9 is a block diagram of a computer device, according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0047] In order to make the objects, technical solutions, and advantages of the present application clearer, the present application will be described in further detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are merely intended to explain the present application and should not be used to limit the present application.

[0048] In an embodiment, as shown in FIG. 1, a method for determining a radiation irradiation parameter is provided, and the embodiment is exemplarily described by taking the method as applied to a terminal. It should be understood that the method can also be applied to a server, and can also be applied to a system including a terminal and a server, and can be realized through interaction between the terminal and the server.

[0049] In an optional embodiment, the method includes the following steps.

[0050] In step 102, an initial irradiation center point and an initial irradiation angle are determined based on a first positional relationship between a target irradiation region and an irradiation object. The target irradiation region is a part of the irradiation object, and the radiation is generated by a radiation source. The target irradiation region is located in an effective irradiation field of a radiation outlet.

[0051] In the simulation calculation of the present application, it is assumed that the radiation source is located at the radiation outlet, and the center of the radiation source is the center of the beam outlet.

[0052] Optionally, the electromagnetic radiation can be visible light, ultraviolet, X-ray, gamma ray, etc., and the energy propagation mode is composed of electromagnetic waves. Visible light is electromagnetic waves visible to the human eye, ultraviolet, X-ray and gamma ray have higher energy and shorter wavelength, and can penetrate matter and have different effects on biological tissues. Particle radiation can be alpha particles, beta particles, neutrons, etc. Alpha particles are charged particles composed of two protons and two neutrons, and are relatively large and heavy. Beta particles are high-speed electrons or positrons with negative charge. Neutrons are neutral particles without charge.

[0053] The target irradiation region is a substance that needs to be treated by radiation, such as a tumor that needs to be inactivated by neutron irradiation. The target irradiation region is located inside the irradiation object, such as a tumor located in an animal body or a human body, and the animal body or the human body is the irradiation object. Referring to FIG. 2, FIG. 2 shows a schematic diagram of the positional relationship between the radiation outlet, the irradiation object and the target irradiation region in an embodiment. After the radiation is emitted from the radiation outlet 202, it irradiates the target irradiation region 206 through part of the irradiation object 204.

[0054] The first positional relationship is determined based on the orientation of the target irradiation region in the irradiation object, and can include the distance between the target irradiation region and the center of the irradiation object, the distance between the target irradiation region and the edge of the irradiation object, the distance between the plane where the maximum diameter of the target irradiation region is located and the edge of the irradiation object, etc.

[0055] The initial irradiation center point refers to the point where the center axis of the initially determined radiation beam intersects the surface of the irradiation object, and the initial irradiation angle refers to the irradiation angle of the initially determined radiation.

[0056] Step 104, under the condition of fixing the initial irradiation angle, the initial irradiation center point is translated to make the second positional relationship between the target irradiation region and the radiation outlet meet the first preset radiation condition, and the first irradiation position is obtained.

[0057] Wherein, when the initial irradiation center point is translated, the relative position between the center point of the radiation source and the initial irradiation center point is kept unchanged, that is, the center point of the radiation source and the initial irradiation center point are translated together; the initial irradiation center point is translated in the plane perpendicular to the beam direction.

[0058] The first preset radiation condition is a radiation condition that can meet the radiation requirements. Optionally, the first preset radiation condition can include the distance requirement between the irradiation object and the radiation outlet, the projection area requirement of the target irradiation region on the radiation outlet, the proportion of the radiation irradiating the target irradiation region, etc.

[0059] Step 106, the third positional relationship between the irradiation object and the radiation outlet under the first irradiation position is obtained.

[0060] If the third positional relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

[0061] The radiation irradiation parameters at least include an irradiation center point and an irradiation angle. In addition, the radiation irradiation parameters can also include a source skin distance, a target dose, a neutron flux, etc.

[0062] In a feasible implementation, the second preset radiation condition includes that the irradiation object does not contact the radiation outlet.

[0063] In another optional embodiment, the method for determining the radiation irradiation parameters includes the steps 102, 104 and 106, and further includes steps 110 and 112.

[0064] Specifically, in the step 110, if the third positional relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, the source skin distance between the radiation outlet and the irradiation object is increased to a distance at which the irradiation object does not contact the radiation outlet, i.e., the second preset radiation condition is satisfied, and it is determined whether the source skin distance satisfies a preset distance condition.

[0065] The source skin distance SSD represents a distance from a radiation source center point to a surface of the irradiation object along a central axis of a radiation beam, or a distance from the radiation source center point to a center of an irradiation field of the irradiation object. Alternatively, a center of the beam outlet or a center of a target surface for generating radiation is taken as the radiation source center point.

[0066] The preset distance condition is applicable to the source skin distance. The target irradiation region is located at different positions of the irradiation object, and the source skin distance requirement is different, so the preset distance condition is different. For example, in the BNCT (Boron Neutron Capture Therapy), when a tumor is located in a head, the source skin distance requirement is within 3 mm, when the tumor is located in a face, the source skin distance requirement is within 30 mm, and when the tumor is located in a neck, the source skin distance requirement is within 50 mm.

[0067] In the step 112, if the source skin distance satisfies the preset distance condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

[0068] In the method for determining the radiation irradiation parameter, the initial irradiation center point and the initial irradiation angle are determined based on the first positional relationship between the target irradiation region and the irradiation object; the initial irradiation center point is translated under the condition of fixing the initial irradiation angle, and the first preset radiation condition, the second preset radiation condition and the preset distance condition of the source-skin distance are judged to obtain the radiation irradiation parameter meeting the irradiation requirement. The first preset radiation condition is set to ensure that the target irradiation region is located in the effective irradiation field range and to reduce the dose received by the pre-protection region. The second preset radiation condition is set to facilitate the positioning adjustment of the irradiation object. The source-skin distance is limited to meet the preset distance condition to ensure the irradiation treatment effect.

[0069] In the above embodiment, the initial irradiation center point and the initial irradiation angle are determined based on the first positional relationship between the target irradiation region and the irradiation object, including: determining the longest diameter of the target irradiation region; determining the shortest distance between the plane where the longest diameter is located and the surface of the irradiation object; taking the intersection point of the straight line where the shortest distance is located and the surface of the irradiation object as the initial irradiation center point, and taking the irradiation angle that satisfies the coincidence of the straight line where the shortest distance is located and the center point of the radiation source with the initial irradiation center point as the initial irradiation angle.

[0070] The target irradiation region can be a special-shaped structure, and the diameters at different angles are not equal. The longest diameter refers to the longest diameter of the target irradiation region.

[0071] Since the surface of the irradiation object can be a non-uniform surface, the distance between the plane where the longest diameter is located and the surface of the irradiation object is non-uniform, and the shortest vertical distance is the shortest distance.

[0072] In the embodiment, the initial irradiation center point and the initial irradiation angle are determined based on the shortest distance between the plane where the longest diameter of the target irradiation region is located and the surface of the irradiation object, which can maximize the coverage of the radiation on the target irradiation region and ensure the intensity of the radiation reaching the target irradiation region and the irradiation effect.

[0073] As shown in FIG. 3, in an exemplary embodiment, step 104 translates the initial irradiation center point under the condition of fixing the initial irradiation angle to make the second positional relationship between the target irradiation region and the radiation outlet meet the first preset radiation condition to obtain the first irradiation position, including:

[0074] Step 302, determining the pre-protection region of the irradiation object.

[0075] The pre-protection region is a substance or tissue on the irradiation object that is not expected to be irradiated by the radiation, which can be located on the surface of the irradiation object or inside the irradiation object.

[0076] Alternatively, during radiotherapy, the pre-protection area can be the primary organ at risk, which is the human organ that is to be avoided during radiotherapy, such as normal brain tissue, oral mucosa, and eyeballs.

[0077] Step 304: Under the condition of a fixed initial irradiation angle, the initial irradiation center point is translated, and multiple alternative irradiation positions are obtained when the second positional relationship between the target irradiation area and the radiation outlet satisfies the first preset radiation condition.

[0078] The first preset radiation condition is the radiation condition that must be met during radiation irradiation.

[0079] Step 306: Obtain multiple projected areas of the pre-protected area within the effective radiation field of the radiation exit along the initial radiation angle direction from multiple candidate irradiation positions, and select the candidate irradiation position with the smallest projected area as the first irradiation position.

[0080] Among these, there may be multiple alternative irradiation locations that meet the preset radiation conditions that the target irradiation area is located in the effective irradiation area. The minimum projected area means that among these feasible alternative locations, the area of ​​the pre-protected area projected onto the radiation exit is the smallest, so as to ensure that the pre-protected area is minimally affected.

[0081] In this embodiment, the initial irradiation center point is shifted under preset radiation conditions to obtain multiple candidate irradiation positions that meet the conditions. To minimize the impact on the pre-protected area during irradiation, the projected area of ​​the pre-protected area at the radiation exit is determined at each candidate irradiation position, and the candidate irradiation position with the smallest projected area is selected as the first irradiation position. In this way, when the radiation exits and irradiates the target irradiation area, the radiation dose received by the pre-protected area is minimized, reducing radiation damage to the pre-protected area while ensuring that the irradiated area receives a sufficient dose of radiation.

[0082] In an exemplary embodiment, the first preset radiation condition includes: the target irradiation area is located within the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation area and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

[0083] Optionally, when the radiation is neutron, the target irradiation region is tumor, i.e. BNCT radiation therapy is performed, it is necessary to ensure that the tumor is located in the effective irradiation range. Taking neutron flux as an example, the permissible neutron flux in the irradiation plane is more than 80% of the neutron flux emitted by the radiation outlet, and the range below 20% is considered as the ineffective irradiation field, so the tumor should be located in the effective irradiation field range of the radiation outlet. In addition, it should also meet the effective irradiation requirements of IAEA (International Atomic Energy Agency), the distance between the tumor edge and the radiation outlet edge should be above the preset distance threshold, which is set to 0mm-5mm. Ensure that the tumor can effectively receive neutron flux; the permissible field range is 5mm away from the edge of the radiation outlet, considering the possibility of displacement and neutron beam uniformity, limited to 5mm to ensure that the tumor is in the field range.

[0084] Wherein, the neutron flux refers to the number of neutrons per unit area per unit time, which can be used to evaluate the intensity and dose of neutron irradiation.

[0085] In this embodiment, the target irradiation region is located in the effective irradiation field of the radiation outlet, ensuring the effectiveness of the irradiation; the edge of the target irradiation region is greater than or equal to the preset distance threshold from the edge of the radiation outlet, the closer the target irradiation region is to the center of the radiation outlet, i.e. the farther the target irradiation region is from the edge of the radiation outlet, the higher the intensity of the received radiation, the better the irradiation effect, which can ensure the irradiation effect.

[0086] Referring to FIG. 4, in one exemplary embodiment thereof, the radiation irradiation parameter determination method further comprises the following steps:

[0087] Step 402, if the source skin distance does not meet the preset distance condition, the initial irradiation center point is kept unchanged, and the initial irradiation angle is changed in the preset angle range to obtain a plurality of reference irradiation angles.

[0088] Wherein, if the source skin distance does not meet the requirement after increasing the distance between the radiation outlet and the irradiation object, the irradiation angle needs to be determined again.

[0089] In a certain angle range, the initial irradiation angle is deflected to obtain a plurality of reference irradiation angles.

[0090] In one feasible implementation, the process of changing the initial irradiation angle in the preset angle range includes: establishing an X-Y-Z three-dimensional coordinate with the center point of the radiation source as the origin, and the radiation outlet direction as the X axis, and deflecting the X-Y plane by θ angle around the initial irradiation center point at the shortest distance, or deflecting the X-Z plane by Φ angle around the initial irradiation center point at the shortest distance.

[0091] The angle of the theta angle is an integer in the range of [-5, 5], and the angle of the phi angle is an integer in the range of [-5, 5]. The irradiation angle is offset by one degree each time steps 102-112 are performed.

[0092] In another possible implementation, a spherical coordinate system or a cylindrical coordinate system is established with the center point of the radiation source as the origin, and the initial irradiation angle as 0 degrees, and the polar angle or the azimuth angle is offset by a certain angle from 0 degrees.

[0093] In step 404, for each reference irradiation angle, the initial irradiation center point is translated under the condition of fixing the reference irradiation angle, so that the target irradiation region and the second position relationship of the radiation outlet satisfy the first preset radiation condition, to obtain a plurality of reference irradiation positions; and it is determined whether the third position relationship between the irradiation object and the radiation outlet under each reference irradiation position satisfies the second preset radiation condition.

[0094] In the above implementation, after the initial irradiation angle is rotated, the processing method similar to the initial irradiation angle can be used to obtain a plurality of reference irradiation positions for each reference irradiation angle.

[0095] In the above implementation, the first preset radiation condition includes that the target irradiation region is located in the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation region and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

[0096] The second preset radiation condition includes that the surface of the irradiation object does not interfere with the radiation outlet.

[0097] In step 405, if the third position relationship between the irradiation object and the radiation outlet satisfies the second preset radiation condition, the initial irradiation center point and the reference irradiation angle are taken as the irradiation line irradiation reference parameters.

[0098] In step 406, if the third position relationship between the irradiation object and the radiation outlet does not satisfy the second preset radiation condition, the source-skin distance between the irradiation object and the radiation outlet is increased to the distance at which the irradiation object does not interfere with the radiation outlet, i.e., the second preset radiation condition is satisfied, and then it is determined whether the source-skin distance between the radiation outlet and the irradiation object satisfies a preset distance condition.

[0099] In step 408, if the source-skin distance satisfies the preset distance condition, the initial irradiation center point and the reference irradiation angle are taken as the radiation irradiation reference parameters.

[0100] In step 410, the farthest distance between the target irradiation region and the radiation outlet under each irradiation line irradiation reference parameter is determined, and the reference parameter with the smallest farthest distance is taken as the radiation irradiation parameter.

[0101] The farthest distance refers to the distance from the deepest part of the target irradiation region to the exit of the radiation along the direction of the radiation irradiation. Since the irradiation intensity decays with distance, the smaller the distance, the higher the irradiation efficiency of the radiation.

[0102] In the embodiment, for the case where the source-skin distance does not satisfy the preset distance condition, the initial irradiation angle is changed in the preset angle range to obtain a plurality of reference irradiation angles, a plurality of reference irradiation positions satisfying the first preset irradiation condition are obtained for each reference irradiation angle, and the reference parameters satisfying the conditions are obtained according to the second preset irradiation condition and the preset distance condition. The reference parameter with the smallest farthest distance between the target irradiation region and the exit of the radiation is taken as the irradiation parameter, thereby improving the irradiation effect of the radiation on the target irradiation region.

[0103] In an exemplary embodiment, the radiation irradiation parameter determination method further comprises: re-determining a second initial irradiation center point and a second initial irradiation angle. Specifically, if the source-skin distance between the exit of the radiation and the irradiation object does not satisfy the preset distance condition at each reference irradiation position, it is determined that the current initial irradiation center point does not meet the radiation irradiation requirement. The current initial irradiation center point and the initial irradiation angle are excluded, and the second initial irradiation center point and the second initial irradiation angle are determined based on the fourth positional relationship between the target irradiation region and the irradiation object.

[0104] If no reference parameter is obtained at each reference irradiation position of all reference irradiation angles, it is considered that there is no irradiation angle that meets the irradiation requirement and matches the initially determined initial irradiation center point. After excluding the current initial irradiation center point and the initial irradiation angle, the second initial irradiation center point and the second initial irradiation angle are re-determined.

[0105] As shown in FIG. 5, in an exemplary embodiment, the second initial irradiation center point and the second initial irradiation angle are re-determined based on the fourth positional relationship between the target irradiation region and the irradiation object, comprising the following steps:

[0106] Step 502, the cut surface of the longest diameter of the target irradiation region and the cut surface within the angle of -a~+a rotated from the cut surface of the longest diameter are excluded.

[0107] The cut surface of the longest diameter and the cut surface within the angle of -a~+a rotated from the cut surface of the longest diameter are considered to have no irradiation parameter that meets the requirement.

[0108] Optionally, the angle a is 5 degrees. At this time, the cut surface of the longest diameter of the target irradiation region and the cut surface within the angle of -5~+5 rotated from the cut surface of the longest diameter are excluded.

[0109] Step 504, defining the longest diameter of the remaining part of the target irradiation region as a second longest diameter, and defining the shortest distance between the plane where the second longest diameter is located and the surface of the irradiation object as a second shortest distance.

[0110] Step 506, taking the intersection between the line where the second shortest distance is located and the surface of the irradiation object as a second initial irradiation center point, and taking the irradiation angle that satisfies the condition that the line where the second shortest distance is located coincides with the center point of the radiation source and the second initial irradiation center point as a second initial irradiation angle.

[0111] In this embodiment, when the longest diameter cannot determine the irradiation parameters, the longest diameter and a certain range of parameters are removed, and the second longest diameter and the second shortest distance are constructed based on the remaining target irradiation region, so as to construct the second initial irradiation center point and the second initial irradiation angle. Further, similar to the method of determining the irradiation parameters according to the initial irradiation angle and the initial irradiation position, the irradiation parameters are re-determined based on the second initial irradiation center point and the second initial irradiation angle. In this way, when the longest diameter cannot determine the irradiation parameters, the irradiation parameters can be determined based on the second longest diameter.

[0112] Referring to FIGS. 6A and 6B, FIGS. 6A and 6B show a flowchart of the steps of the method for determining the radiation irradiation parameters in another embodiment, including the following steps:

[0113] Step 602, determining the longest diameter of the target irradiation region; and determining the shortest distance between the plane where the longest diameter is located and the surface of the irradiation object.

[0114] Step 604, taking the intersection between the line where the shortest distance is located and the surface of the irradiation object as an initial irradiation center point, and taking the irradiation angle that satisfies the condition that the line where the shortest distance is located coincides with the center point of the radiation source and the initial irradiation center point as an initial irradiation angle. The target irradiation region is a part of the irradiation object, the radiation is generated by a radiation source, and the target irradiation region is located in the effective irradiation field of the radiation outlet.

[0115] Step 606, determining a pre-protection region of the irradiation object.

[0116] Step 608, translating the initial irradiation center point under the condition that the initial irradiation angle is fixed, and obtaining a plurality of candidate irradiation positions in the case that the second positional relationship between the target irradiation region and the radiation outlet satisfies the first preset radiation condition. The target irradiation region is located in the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation region and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

[0117] Step 610, obtaining a plurality of projection areas of the pre-protection region in the effective irradiation field of the radiation outlet along the direction of the initial irradiation angle in the plurality of candidate irradiation positions, and taking the candidate irradiation position with the smallest projection area as a first irradiation position.

[0118] Step 612, obtaining a third positional relationship between the irradiation object and the radiation outlet under the first irradiation position.

[0119] Step 614, if the third positional relationship between the irradiation object and the radiation outlet meets a second preset radiation condition, taking the initial irradiation center point and the initial irradiation angle as the radiation irradiation parameters; the second preset radiation condition includes that the irradiation object does not interfere with the radiation outlet.

[0120] Step 616, if the third positional relationship between the irradiation object and the radiation outlet does not meet the second preset radiation condition, increasing the source-skin distance between the radiation outlet and the irradiation object to the surface of the irradiation object and the radiation outlet not interfering, and judging whether the source-skin distance meets a preset distance condition.

[0121] Step 618, if the source-skin distance meets the preset distance condition, taking the initial irradiation center point and the initial irradiation angle as the radiation irradiation parameters.

[0122] Step 620, if the source-skin distance does not meet the preset distance condition, keeping the initial irradiation center point unchanged, establishing an X-Y-Z three-dimensional coordinate with the center point of the radiation source as the origin, the radiation outlet direction as the X axis, and the shortest distance deviating from the X axis by an angle θ in the X-Y plane or the shortest distance deviating from the X axis by an angle Φ in the X-Z plane around the initial irradiation center point to obtain a plurality of reference irradiation angles.

[0123] Step 622, for each reference irradiation angle, under the condition of fixing the reference irradiation angle, translating the initial irradiation center point to make the second positional relationship between the target irradiation region and the radiation outlet meet the first preset radiation condition to obtain a plurality of reference irradiation positions; and judging whether the third positional relationship between the irradiation object and the radiation outlet under each reference irradiation position meets the second preset radiation condition.

[0124] Step 623, if the second preset radiation condition is met, taking the initial irradiation center point and the reference irradiation angle meeting the condition as the radiation irradiation reference parameters.

[0125] Step 624, if the third positional relationship between the irradiation object and the radiation outlet does not meet the second preset radiation condition, increasing the source-skin distance to make the irradiation object and the radiation outlet not interfere, and then judging whether the source-skin distance between the radiation outlet and the irradiation object meets the preset distance condition.

[0126] Step 626, if the source-skin distance meets the preset distance condition, taking the initial irradiation center point and the reference irradiation angle as the radiation irradiation reference parameters.

[0127] Step 628, determining the farthest distance between the target irradiation region and the radiation outlet in each reference parameter, and taking the reference parameter with the smallest farthest distance as the radiation irradiation parameter.

[0128] If the source skin distance does not satisfy the preset distance condition, the second initial irradiation center point and the second initial irradiation angle need to be determined again.

[0129] Specifically, if the source skin distance of the radiation outlet and the irradiation object does not satisfy the preset distance condition at each reference irradiation position, it is determined that the current initial irradiation center point does not meet the radiation irradiation requirement.

[0130] In step 632, the current initial irradiation center point and the initial irradiation angle are excluded, and the section of the longest diameter of the target irradiation region and the section within the angle of -α~+α of the longest diameter are excluded.

[0131] In step 634, the longest diameter of the remaining part of the target irradiation region is defined as a second longest diameter, and the shortest distance between the plane where the second longest diameter is located and the surface of the irradiation object is defined as a second shortest distance.

[0132] In step 636, the intersection between the line where the second shortest distance is located and the surface of the irradiation object is taken as the second initial irradiation center point, and the irradiation angle that satisfies the condition that the line where the second shortest distance is located coincides with the center point of the radiation source and the second initial irradiation center point is taken as the second initial irradiation angle.

[0133] It should be understood that, although each step in the flowchart involved in the above embodiments is displayed in sequence according to the arrow, these steps are not necessarily executed in the order indicated by the arrow. Unless otherwise specified herein, the execution of these steps is not strictly limited in sequence, and these steps can be executed in other orders. Moreover, at least part of the steps in the flowchart involved in the above embodiments can include multiple steps or multiple stages, which are not necessarily executed at the same time, but can be executed at different times, and the execution sequence of these steps or stages is not necessarily sequential, but can be executed in rotation or alternation with at least part of other steps or stages.

[0134] Based on the same inventive concept, the embodiments of the present application also provide a radiation irradiation parameter determination device for implementing the above-mentioned radiation irradiation parameter determination method. The implementation scheme for solving the problem provided by the device is similar to the implementation scheme described in the above method, and therefore the specific limitations in one or more radiation irradiation parameter determination device embodiments provided below can refer to the limitations of the radiation irradiation parameter determination method described above, which will not be repeated here.

[0135] In an exemplary embodiment, as shown in FIG. 7, a radiation irradiation parameter determination device 700 is provided, which includes a parameter preset module 702 and a parameter screening module 704:

[0136] The parameter preset module 702 is configured to determine an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and the irradiation object, the target irradiation region being a part of the irradiation object, the radioactive rays being generated by the radioactive source and emitted from the radioactive ray outlet, and the target irradiation region being located in the effective irradiation field of the radioactive ray outlet.

[0137] The parameter screening module 704 is configured to translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, so that a second positional relationship between the target irradiation region and the radioactive ray outlet satisfies a first preset irradiation condition, to obtain a first irradiation position, and to obtain a third positional relationship between the irradiation object and the radioactive ray outlet under the first irradiation position, and if the third positional relationship between the irradiation object and the radioactive ray outlet satisfies a second preset irradiation condition, to determine the initial irradiation center point and the initial irradiation angle as the radioactive ray irradiation parameters.

[0138] In an exemplary embodiment, the parameter preset module 702 is further configured to, if the third positional relationship between the irradiation object and the radioactive ray outlet does not satisfy the second preset irradiation condition, increase a source-skin distance between the radioactive ray outlet and the irradiation object to a distance at which the surface of the irradiation object does not interfere with the radioactive ray outlet, determine whether the source-skin distance satisfies a preset distance condition, and if the source-skin distance satisfies the preset distance condition, determine the initial irradiation center point and the initial irradiation angle as the radioactive ray irradiation parameters.

[0139] In an exemplary embodiment, the parameter preset module 702 is further configured to determine a longest diameter of the target irradiation region, determine a shortest distance between a plane on which the longest diameter is located and a surface of the irradiation object, and determine an intersection point between a straight line on which the shortest distance is located and the surface of the irradiation object as the initial irradiation center point, and determine an irradiation angle at which the straight line on which the shortest distance is located coincides with the initial irradiation center point and a center point of the radioactive source as the initial irradiation angle.

[0140] In an exemplary embodiment, the parameter screening module 704 is further configured to determine a pre-protection region of the irradiation object, translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, and obtain a plurality of candidate irradiation positions in a case where the second positional relationship between the target irradiation region and the radioactive ray outlet satisfies the first preset irradiation condition, and obtain a plurality of projection areas of the pre-protection region in the effective irradiation field of the radioactive ray outlet along the initial irradiation angle direction in the plurality of candidate irradiation positions, and determine a candidate irradiation position with the smallest projection area as the first irradiation position.

[0141] In an exemplary embodiment, the first preset irradiation condition includes that the target irradiation region is located in the effective irradiation field of the radioactive ray outlet, and an edge of the target irradiation region is located at a distance greater than or equal to a preset distance threshold value from an edge of the radioactive ray outlet.

[0142] In an example embodiment, the second preset radiation condition comprises that the irradiation object does not contact the radiation outlet.

[0143] In an example embodiment, the parameter screening module 704 is further configured to: if the source-skin distance does not satisfy the preset distance condition, keep the initial irradiation center point unchanged, change the initial irradiation angle in a preset angle range to obtain a plurality of reference irradiation angles; for each reference irradiation angle, translate the initial irradiation center point under the condition of fixing the reference irradiation angle, so that the second positional relationship between the target irradiation region and the radiation outlet satisfies the first preset radiation condition to obtain a plurality of reference irradiation positions; judge whether the third positional relationship between the irradiation object and the radiation outlet under each irradiation position satisfies the second preset radiation condition, if the second preset radiation condition is satisfied, the initial irradiation center point and the reference irradiation angle are taken as the reference parameters for radiation irradiation; if the second preset radiation condition is not satisfied, the source-skin distance between the radiation outlet and the irradiation object is increased to make the irradiation object not contact the radiation outlet, so that the third positional relationship satisfies the second preset radiation condition, and then it is judged whether the source-skin distance satisfies the preset distance condition; if the preset distance condition is satisfied, the initial irradiation center point and the reference irradiation angle are taken as the reference parameters for radiation irradiation; and the farthest distance between the target irradiation region and the radiation outlet in each reference parameter is determined, and the reference parameter with the smallest farthest distance is taken as the radiation irradiation parameter.

[0144] In an example embodiment, the initial irradiation angle is changed in a preset angle range, specifically: an X-Y-Z three-dimensional coordinate is established with the center point of the radiation source as the origin, and the radiation outlet direction is the X axis; the shortest distance deviates from the X axis by an angle θ in the X-Y plane around the initial irradiation center point, or the shortest distance deviates from the X axis by an angle Φ in the X-Z plane around the initial irradiation center point.

[0145] The angle θ is an integer in the range of [-5, 5], and the angle range of the angle Φ is an integer in the range of [-5, 5].

[0146] In an example embodiment, the parameter preset module 702 is further configured to: redetermine the second initial irradiation center point and the second initial irradiation angle; specifically, if the source-skin distance between the radiation outlet and the irradiation object does not satisfy the preset distance condition at each reference irradiation position, it is determined that the current initial irradiation center point does not meet the requirements of radiation irradiation; the current initial irradiation center point and the initial irradiation angle are excluded, and the second initial irradiation center point and the second initial irradiation angle are determined based on the fourth positional relationship between the target irradiation region and the irradiation object.

[0147] In an exemplary embodiment, the re-determination of the second initial irradiation center point and the second initial irradiation angle based on the target irradiation region and the fourth positional relationship of the irradiation object comprises: excluding the tangent of the longest diameter of the target irradiation region and the tangent within the -a~+a angle of the tangent of the longest diameter; defining the longest diameter of the remaining part of the target irradiation region as a second longest diameter, and defining the shortest distance between the plane where the second longest diameter is located and the surface of the irradiation object as a second shortest distance; taking the intersection point between the line where the second shortest distance is located and the surface of the irradiation object as the second initial irradiation center point, and taking the irradiation angle that satisfies the coincidence of the line where the second shortest distance is located and the center point of the radiation source with the second initial irradiation center point as the second initial irradiation angle.

[0148] In an exemplary embodiment, the a angle is 5 degrees.

[0149] The modules in the above-described radiation irradiation parameter determination apparatus can be realized by software, hardware, or a combination thereof, in whole or in part. The modules can be embedded in or independent of a processor in a computer device in hardware form, or stored in a memory in a computer device in software form, so as to be called and executed by a processor to perform the operations corresponding to the modules.

[0150] As shown in FIG. 8, FIG. 8 shows a structural schematic diagram of a radiation therapy system in an embodiment, which comprises: a placement table 802 for supporting the irradiation object 204; a radiation generation apparatus 804 comprising the radiation outlet 202, the radiation generation apparatus 804 being configured to generate radiation and emit the radiation from the radiation outlet 202; and the above-described radiation irradiation parameter determination apparatus.

[0151] Optionally, the radiation generation apparatus 804 can be a neutron generation apparatus comprising an accelerator, a target beam shaping body, and a collimator, wherein the collimator serves as the radiation outlet 202. The accelerator accelerates the generated charged particle line to interact with the target material to generate a neutron line. The beam shaping body comprises a reflector, a moderator, a thermal neutron absorber, a radiation shielding body, and a beam outlet. The moderator slows down the neutrons generated from the target material to the super-thermal neutron energy region. The reflector surrounds the moderator and guides the deviated neutrons back to the moderator to improve the super-thermal neutron beam intensity. The thermal neutron absorber is used to absorb thermal neutrons to avoid excessive dose to the shallow normal tissue during treatment. The radiation shielding body is arranged at the rear part of the reflector around the beam outlet to shield the leaked neutrons and photons to reduce the dose to the normal tissue in the non-irradiation region. Then the neutrons are emitted after passing through the collimator.

[0152] In an example embodiment, a computer device, which can be a server, is provided, and an internal structure diagram of the computer device can be as shown in FIG. 9. The computer device includes a processor, a memory, an input / output interface (I / O) and a communication interface. The processor, the memory and the input / output interface are connected through a system bus, and the communication interface is connected to the system bus through the input / output interface. The processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for running the operating system and the computer program in the non-volatile storage medium. The database of the computer device is configured to store irradiation parameter data. The input / output interface of the computer device is configured to exchange information between the processor and external devices. The communication interface of the computer device is configured to communicate with terminals outside through a network connection. The computer program is executed by the processor to implement a method for determining a radiation irradiation parameter.

[0153] Those skilled in the art can understand that the structure shown in FIG. 9 is only a block diagram of part of the structure related to the scheme of the present application, and does not constitute a limitation on the computer device to which the scheme of the present application is applied. The specific computer device can include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0154] In an example embodiment, a computer device is provided, including a memory and a processor, the memory storing a computer program, and the processor executing the computer program to implement the steps in the above method embodiments.

[0155] In an example embodiment, a computer readable storage medium is provided, storing a computer program, and the computer program is executed by a processor to implement the steps in the above method embodiments.

[0156] In an example embodiment, a computer program product is provided, including a computer program, and the computer program is executed by a processor to implement the steps in the above method embodiments.

[0157] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program. The computer program can be stored in a non-volatile computer readable storage medium, and when the computer program is executed, the processes of the above-mentioned embodiments of the methods can be included. Any reference to memory, database or other medium used in the embodiments provided in the present application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (Read-Only Memory, ROM), magnetic tape, floppy disk, flash memory, optical storage, high-density embedded non-volatile memory, resistive memory (ReRAM), magnetoresistive memory (Magnetoresistive Random Access Memory, MRAM), ferroelectric memory (Ferroelectric Random Access Memory, FRAM), phase change memory (Phase Change Memory, PCM), graphene memory, etc. Volatile memory can include random access memory (Random Access Memory, RAM) or external cache memory, etc. As an illustration but not limitation, RAM can be in various forms, such as static random access memory (Static Random Access Memory, SRAM) or dynamic random access memory (Dynamic Random Access Memory, DRAM), etc. The database involved in the embodiments provided in the present application can include at least one of a relational database and a non-relational database. The non-relational database can include a distributed database based on a block chain, etc., without being limited thereto. The processor involved in the embodiments provided in the present application can be a general-purpose processor, a central processing unit, a graphics processing unit, a digital signal processor, a programmable logic device, a data processing logic device based on quantum computing, etc., without being limited thereto.

[0158] Any combination of the technical features of the above embodiments can be made. In order to make the description simple, all possible combinations of the technical features in the above embodiments are not described, however, as long as the combination of the technical features does not exist contradictory, it should be considered as the scope of the present application.

[0159] The above embodiments only express several implementation manners of the present application, and the description is more specific and detailed, but it should not be understood as a limitation on the scope of the patent of the present application. It should be noted that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are within the scope of protection of the present application. Therefore, the protection scope of the present application should be subject to the appended claims.

Claims

1. A device for determining radiation irradiation parameters, characterized in that, The device comprises: a parameter preset module configured to determine an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, wherein the target irradiation region is a part of the irradiation object, the radioactive rays are generated by a radioactive source, and the target irradiation region is located in an effective irradiation field of a radioactive ray outlet; a parameter screening module configured to translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, so that a second positional relationship between the target irradiation region and the radioactive ray outlet satisfies a first preset radioactive condition, and obtain a first irradiation position; the parameter screening module is further configured to obtain a third positional relationship between the irradiation object and the radioactive ray outlet at the first irradiation position, and if the third positional relationship between the irradiation object and the radioactive ray outlet satisfies a second preset radioactive condition, the initial irradiation center point and the initial irradiation angle are taken as radioactive ray irradiation parameters.

2. The apparatus of claim 1, wherein, The parameter preset module is further configured to: determine a longest diameter of the target irradiation region, determine a shortest distance between a plane where the longest diameter is located and a surface of the irradiation object, take an intersection point between a straight line where the shortest distance is located and the surface of the irradiation object as the initial irradiation center point, and take an irradiation angle that satisfies a condition that the straight line where the shortest distance is located coincides with the initial irradiation center point and a center point of the radioactive source as the initial irradiation angle.

3. The apparatus of claim 2, wherein, The parameter screening module is further configured to: determine a pre-protection region of the irradiation object, translate the initial irradiation center point under the condition that the initial irradiation angle is fixed, obtain a plurality of alternative irradiation positions in a case that the second positional relationship between the target irradiation region and the radioactive ray outlet satisfies the first preset radioactive condition, and obtain a plurality of projection areas of the pre-protection region in the effective irradiation field of the radioactive ray outlet along the initial irradiation angle direction in the plurality of alternative irradiation positions, and take an alternative irradiation position with the smallest projection area as the first irradiation position.

4. The apparatus of claim 1, wherein, The first preset radioactive condition comprises that the target irradiation region is located in the effective irradiation field of the radioactive ray outlet, and an edge of the target irradiation region is located at a distance greater than or equal to a preset distance threshold value from an edge of the radioactive ray outlet.

5. The apparatus of claim 4, wherein, The second preset radioactive condition comprises that the irradiation object does not interfere with the radioactive ray outlet.

6. The apparatus of claim 2, wherein, The parameter screening module is further configured to: if the third positional relationship between the irradiation object and the radioactive ray outlet does not satisfy the second preset radioactive condition, increase a source-skin distance between the radioactive ray outlet and the irradiation object to a third positional relationship between the surface of the irradiation object and the radioactive ray outlet that satisfies the second preset radioactive condition, determine whether the source-skin distance satisfies a preset distance condition, and if the source-skin distance satisfies the preset distance condition, take the initial irradiation center point and the initial irradiation angle as the radioactive ray irradiation parameters.

7. A radiation exposure parameter determination method, characterized by, The method comprises: determining an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, wherein the target irradiation region is a part of the irradiation object, the radioactive rays are generated by a radioactive source, and the target irradiation region is located in an effective irradiation field of a radioactive ray outlet; Translate the initial irradiation center point under the condition of fixing the initial irradiation angle, so that the second positional relationship between the target irradiation region and the radiation outlet meets the first preset radiation condition, and a first irradiation position is obtained; Obtain the third positional relationship between the irradiation object and the radiation outlet under the first irradiation position; If the third positional relationship between the irradiation object and the radiation outlet meets the second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

8. The method of claim 7, wherein, The initial irradiation center point and the initial irradiation angle are determined based on the first positional relationship between the target irradiation region and the irradiation object, including: Determine the longest diameter of the target irradiation region; Determine the shortest distance between the plane where the longest diameter is located and the surface of the irradiation object; The intersection point of the straight line where the shortest distance is located and the surface of the irradiation object is taken as the initial irradiation center point, and the irradiation angle that meets the coincidence of the straight line where the shortest distance is located, the initial irradiation center point and the center point of the radiation source is taken as the initial irradiation angle.

9. The method of claim 8, wherein, The initial irradiation center point is translated under the condition of fixing the initial irradiation angle, so that the second positional relationship between the target irradiation region and the radiation outlet meets the first preset radiation condition, and a first irradiation position is obtained, including: Determine the pre-protection area of the irradiation object; Translate the initial irradiation center point under the condition of fixing the initial irradiation angle, and obtain a plurality of alternative irradiation positions when the second positional relationship between the target irradiation region and the radiation outlet meets the first preset radiation condition; Obtain a plurality of projection areas of the pre-protection area in the effective irradiation field of the radiation outlet along the initial irradiation angle direction in a plurality of alternative irradiation positions, and take the alternative irradiation position with the smallest projection area as the first irradiation position.

10. The method according to claim 7 or 9, characterized in that, The first preset radiation condition includes that the target irradiation region is located in the effective irradiation field of the radiation outlet, and the distance between the edge of the target irradiation region and the edge of the radiation outlet is greater than or equal to a preset distance threshold.

11. The method of claim 10, wherein, The second preset radiation condition includes that the irradiation object does not interfere with the radiation outlet.

12. The method of claim 8, wherein, The method further includes: If the third positional relationship between the irradiation object and the radiation outlet does not meet the second preset radiation condition, increase the source-skin distance between the radiation outlet and the irradiation object to the third positional relationship between the surface of the irradiation object and the radiation outlet meets the second preset radiation condition, and determine whether the source-skin distance meets the preset distance condition; If the source-skin distance meets the preset distance condition, the initial irradiation center point and the initial irradiation angle are taken as the radiation irradiation parameters.

13. A radiotherapy system, characterized by, It includes: A placing device for supporting the irradiation object; A radiation generating device including a radiation source and a radiation outlet; The radiation source generates radiation, and the radiation generated by the radiation source is emitted from the radiation outlet and irradiates the irradiation object; A radiation irradiation parameter determination device, the radiation irradiation parameter determination device includes: The parameter preset module is configured to determine an initial irradiation center point and an initial irradiation angle based on a first positional relationship between a target irradiation region and an irradiation object, the target irradiation region being a part of the irradiation object, the radiation being generated by a radiation source, and the target irradiation region being located in an effective irradiation field of a radiation outlet; The parameter screening module is configured to translate the initial irradiation center point under a condition of fixing the initial irradiation angle, so that a second positional relationship between the target irradiation region and the radiation outlet satisfies a first preset radiation condition, and a first irradiation position is obtained. The parameter screening module is further configured to obtain a third positional relationship between the irradiation object and the radiation outlet at the first irradiation position, and if the third positional relationship between the irradiation object and the radiation outlet satisfies a second preset radiation condition, the initial irradiation center point and the initial irradiation angle are taken as radiation irradiation parameters.

14. The radiotherapy system of claim 13, wherein, The first preset radiation condition includes that the target irradiation region is located in the effective irradiation field of the radiation outlet, and an edge of the target irradiation region is located at a distance greater than or equal to a preset distance threshold value from an edge of the radiation outlet.

15. The radiotherapy system of claim 14, wherein, The second preset radiation condition includes that the irradiation object does not interfere with the radiation outlet.

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