Nano-panax notoginseng gel patch and method for preparing same

Abstract

Provided is a method for preparing a nano-panax notoginseng gel patch, comprising the following steps: step I: material selection; step II: nanocrystallization by high-energy ball milling; step III: preparation of the nano-panax notoginseng gel patch; step IV: an ex vivo rabbit skin test; step V: determination of released drug components from the patch; step VI: toxicity and safety study; step VII: screening; and step VIII: data analysis. During the use of the nano-panax notoginseng gel patch, a threaded column pushes an arc-shaped plate to press a panax notoginseng gel plate and a heating mechanism; upon being pressed, the panax notoginseng gel plate deforms and enters the interior of an opening; the contact area between the panax notoginseng gel plate and the skin is controlled by means of the height descent of the arc-shaped plate, and when the heating mechanism is pressed, the heating mechanism adequately heats the panax notoginseng gel plate.

Description

A nano-Panax notoginseng gel patch and its preparation method Technical Field

[0001] This invention relates to the field of Panax notoginseng gel patch equipment, specifically to a nano-Panax notoginseng gel patch and its preparation method. Background Technology

[0002] Panax notoginseng is a traditional Chinese medicine. When preparing Panax notoginseng gel patches, it is necessary to crush and grind the Panax notoginseng to make it fine enough for the next processing step.

[0003] According to patent document CN116869973A, an ibuprofen gel patch and its preparation method are disclosed. The patch includes an ibuprofen gel layer, a backing layer, a constant-temperature heating pack, and an anti-stick film. The constant-temperature heating pack comprises a first pack containing heating material, a second pack containing maifanite granules, and a coating layer. The mass ratio of the heating material in the first pack is: aluminum powder 10%–15%, sodium fluoride 1–5%, calcium hydroxide 15–30%, boron nitride 0.01–3%, iron powder 15–50%, and diatomaceous earth 20–55%. This technical solution, by formulating ibuprofen into a gel patch, avoids the inconvenience of existing gels that easily adhere to clothing during use. This invention also results in drug loss and failure to achieve therapeutic efficacy. The ibuprofen gel patch prepared in this invention contains a constant-temperature heating pack. Ibuprofen utilizes the heat from the constant-temperature heating pack to enhance its medicinal properties, resulting in both synergistic and cumulative effects. Through physical constant-temperature heating, it opens skin pores and sweat pores, dilates capillaries, accelerates local blood circulation, and softens the stratum corneum of the skin, allowing the drug components to quickly and fully penetrate the skin's natural barrier and directly reach the lesion. However, while this solution achieves direct delivery of the drug components to the lesion, it cannot adjust the heating speed and heating time during subsequent local heating. Furthermore, it cannot adjust the contact area between the drug and the skin during use, causing inconvenience during use. Technical issues

[0004] The technical problem to be solved in this application is how to provide a nano-Panax notoginseng gel patch that achieves precise control of drug release through temperature regulation. Technical solutions

[0005] To achieve the above objectives, the present invention is implemented through the following technical solution:

[0006] A method for preparing a nano-Panax notoginseng gel patch, the method comprising the following steps:

[0007] Step 1: Selecting materials;

[0008] Step 2: High-energy ball grinding and nano-sizing;

[0009] Step 3: Fabricate nano-Panax notoginseng gel patches;

[0010] Step 4: In vitro rabbit skin test;

[0011] Step 5: Determine the components of the drug exudate from the patch;

[0012] Step Six: Toxicology and Safety Studies;

[0013] Step 7: Filtering;

[0014] Step 8: Data Analysis;

[0015] In step two, the nano-sizing process involves using high-energy ball milling to pulverize Panax notoginseng. The microstructure is observed using scanning electron microscopy, and the effects of nano-sizing on the content of ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 are determined by HPLC to identify the optimal ball milling process. In step three, the manufacturing process of the Panax notoginseng gel patch involves: first, examining the adhesion of the patch; second, using a Franz-type transdermal diffusion cell device; third, determining the content of saponins by HPLC; fourth, screening the optimal ratio of nano-Panax notoginseng powder and penetration enhancer; and fifth, optimizing the Panax notoginseng nano-gel patch molding process.

[0016] A nano-Panax notoginseng gel patch includes a patch body, the patch body including an adhesive base, a fixing base movably mounted on the adhesive base, a fixing box fixedly mounted on the fixing base, a support plate movably mounted inside the fixing box, a movable plate movably mounted on the support plate, an adhesive sheet fixedly mounted on the bottom inner wall of the adhesive base, a connecting plate fixedly mounted on the adhesive base, a tearing groove between the connecting plates, and a slider fixedly mounted on the connecting plate.

[0017] Furthermore, the bottom of the fixing base has a sliding groove, the slider is movably installed inside the sliding groove, the side of the fixing box has an air inlet, and the top of the fixing box is movably installed with a support assembly.

[0018] Furthermore, a first heating mechanism, a second heating mechanism, and a Panax notoginseng gel plate are fixedly installed on one side of the support plate, and the Panax notoginseng gel plate is fixedly installed at the bottom of the second heating mechanism.

[0019] Furthermore, the second heating mechanism is installed at the bottom of the first heating mechanism, and a partition plate is fixedly installed between the first heating mechanism and the second heating mechanism, with through holes on the partition plate.

[0020] Furthermore, a horizontal plate is fixedly installed on the inner wall of the partition plate, a sealing plate is installed between the horizontal plates, a disconnect groove is opened between the sealing plate and the horizontal plate, and one end of the sealing plate is fixed to the movable plate.

[0021] Furthermore, a limiting component is movably installed on the side of the support plate. The limiting component includes a groove, which is formed on the side of the support plate, and a support mechanism is fixedly installed inside the groove.

[0022] Furthermore, a retaining bead is fixedly installed at one end of the support mechanism, and a retaining hole is movably installed on one side of the retaining bead, the retaining hole being formed on the inner wall of the cavity.

[0023] Furthermore, the top of the fixed box has a storage slot, and the support assembly is movably installed inside the storage slot. The support assembly includes an arc-shaped plate, on which a bearing seat is fixedly installed. A threaded column is rotatably installed on the bearing seat, and the threaded column is rotatably installed on the fixed box.

[0024] Furthermore, the fixing seat has an opening that mates with a tearing groove, and the connecting plate and the adhesive seat are made of soft plastic. Beneficial effects

[0025] This invention discloses a nano-Panax notoginseng gel patch and its preparation method, comprising: an adhesive base; a fixing base; an adhesive plate; a fixing box; a cavity; a support plate; a movable plate; a tearing groove; a support assembly; an air inlet; a connecting plate; a slider; a limiting assembly; a first heating mechanism; a second heating mechanism; a Panax notoginseng gel plate; a partition plate; a through hole; a sealing plate; a sliding groove; a recess; a support mechanism; a retaining bead; a retaining hole; an opening; a storage groove; an arc-shaped plate; a threaded column; a horizontal plate; and a disconnecting groove.

[0026] 1. A nano-Panax notoginseng gel patch and its preparation method are disclosed. During use, a threaded column pushes an arc-shaped plate to compress the Panax notoginseng gel plate and a heating mechanism. After compression, the Panax notoginseng gel plate deforms and enters the interior of the opening. The contact area between the Panax notoginseng gel plate and the skin is controlled according to the height of the descent of the arc-shaped plate. In addition, when the heating mechanism is compressed, the heating mechanism fully heats the Panax notoginseng gel plate. The number of heating mechanisms used is controlled by a sealing plate, and the heating speed and heating temperature are adjusted and controlled to meet the needs of different situations.

[0027] 2. This nano-Panax notoginseng gel patch and its preparation method, after the Panax notoginseng gel plate has been dispersed in the later stage, the arc-shaped plate is removed from the Panax notoginseng gel plate. The Panax notoginseng gel plate and the heating mechanism are taken out together with the support plate. After removal, the adhesive base is not separated from the skin, and the Panax notoginseng gel plate can be replaced and reused at the same time, avoiding the damage to the skin caused by repeated adhesion. In addition, during use, the arc-shaped plate is the point of contact between the Panax notoginseng gel plate and the skin. The drug components inside the Panax notoginseng gel plate slowly move to the lowest point and contact the skin to disperse the drug.

[0028] 3. In this nano-Panax notoginseng gel patch and its preparation method, the width of the opening after the adhesive base is torn open is controlled by the difference between the width of the opening and the width of the adhesive base, which controls the contact area between the Panax notoginseng gel plate and the skin. In addition, the adhesive base slides on the fixed base and is attached to the skin. The movement of the adhesive base expands the contact area with the seal, thereby better adhering and fixing the entire device. Attached Figure Description

[0029] Figure 1 is a schematic diagram of the structure of a nano-Panax notoginseng gel patch preparation method according to the present invention;

[0030] Figure 2 is a three-dimensional structural schematic diagram of a nano-Panax notoginseng gel patch according to the present invention;

[0031] Figure 3 is a schematic diagram of the structure of the adhesive plate of the nano-Panax notoginseng gel patch of the present invention after it is opened;

[0032] Figure 4 is a schematic diagram of the slider structure of a nano-Panax notoginseng gel patch according to the present invention;

[0033] Figure 5 is a schematic diagram of the support plate of the nano-Panax notoginseng gel patch of the present invention;

[0034] Figure 6 is a schematic diagram of the sealing plate structure of a nano-Panax notoginseng gel patch according to the present invention;

[0035] Figure 7 is a side view of the fixing box structure of the nano-Panax notoginseng gel patch of the present invention;

[0036] In the diagram: 1. Adhesive base; 2. Fixing base; 3. Adhesive sheet; 4. Fixing box; 5. Cavity; 6. Support plate; 7. Movable plate; 8. Tear groove; 9. Support assembly; 10. Air inlet; 11. Connecting plate; 12. Slider; 13. Limiting assembly; 14. First heating mechanism; 15. Second heating mechanism; 16. Panax notoginseng gel plate; 17. Divider plate; 18. Through hole; 19. Sealing plate; 20. Slide groove; 21. Groove; 22. Support mechanism; 23. Clamping bead; 24. Clamping hole; 25. Opening; 26. Storage groove; 27. Arc plate; 28. Threaded column; 29. ​​Horizontal plate; 31. Disconnecting groove. Embodiments of the present invention

[0037] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0038] Please refer to Figures 1 to 7. This invention provides a technical solution: a method for preparing a nano-Panax notoginseng gel patch, the preparation method comprising the following steps:

[0039] Step 1: Selecting materials;

[0040] Step 2: High-energy ball grinding and nano-sizing;

[0041] Step 3: Fabricate nano-Panax notoginseng gel patches;

[0042] Step 4: In vitro rabbit skin test;

[0043] Step 5: Determine the components of the drug exudate from the patch;

[0044] Step Six: Toxicology and Safety Studies;

[0045] Step 7: Filtering;

[0046] Step 8: Data Analysis;

[0047] In step two, the nano-sizing process involves using high-energy ball milling to pulverize Panax notoginseng. The microstructure is observed using scanning electron microscopy, and the effects of nano-sizing on the content of ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 are determined by HPLC to identify the optimal ball milling process. In step three, the manufacturing process of the Panax notoginseng gel patch involves: first, examining the adhesion of the patch; second, using a Franz-type transdermal diffusion cell device; third, determining the content of saponins by HPLC; fourth, screening the optimal ratio of nano-Panax notoginseng powder and penetration enhancer; and fifth, optimizing the Panax notoginseng nano-gel patch molding process.

[0048] A nano-Panax notoginseng gel patch includes a patch body, the patch body including an adhesive base 1, a fixing base 2 movably mounted on the adhesive base 1, a fixing box 4 fixedly mounted on the fixing base 2, a support plate 6 movably mounted inside the fixing box 4, a movable plate 7 movably mounted on the support plate 6, an adhesive plate 3 fixedly mounted on the bottom inner wall of the adhesive base 1, a connecting plate 11 fixedly mounted on the adhesive base 1, a tearing groove 8 formed between the connecting plates 11, a slider 12 fixedly mounted on the connecting plate 11, and a [missing information - likely a cut-out pattern] at the bottom of the fixing base 2. The slide 20 has a slider 12 movably installed inside it. The side of the fixed box 4 has an air inlet 10. The top of the fixed box 4 has a support assembly 9 movably installed. The support plate 6 has a first heating mechanism 14, a second heating mechanism 15 and a Panax notoginseng gel plate 16 fixedly installed on one side. The Panax notoginseng gel plate 16 is fixedly installed at the bottom of the second heating mechanism 15. The first heating mechanism 14 and the second heating mechanism 15 are self-heating hand warmers. The Panax notoginseng gel plate 16 is heated by the first heating mechanism 14 and the second heating mechanism 15.

[0049] In this embodiment, the second heating mechanism 15 is installed at the bottom of the first heating mechanism 14. A partition plate 17 is fixedly installed between the first heating mechanism 14 and the second heating mechanism 15. A through hole 18 is opened on the partition plate 17. A horizontal plate 29 is fixedly installed on the inner wall of the partition plate 17. A sealing plate 19 is installed between the horizontal plates 29. A disconnect groove 31 is opened between the sealing plate 19 and the horizontal plate 29. One end of the sealing plate 19 is fixed to the movable plate 7. A limiting component 13 is movably installed on the side of the support plate 6. The limiting component 13 includes a groove 21. The groove 21 is opened on the side of the support plate 6. A support mechanism 22 is fixedly installed inside the groove 21. The support mechanism 22 is a support spring. The support spring pushes the locking ball 23 to move towards the locking hole 24. The locking ball 23 is limited inside the locking hole 24 under the push of the support spring. The locking ball 23 provides limiting support for the support plate 6.

[0050] In this embodiment, a retaining bead 23 is fixedly installed at one end of the support mechanism 22, and a retaining hole 24 is movably installed on one side of the retaining bead 23. The retaining hole 24 is opened on the inner wall of the cavity 5. A storage groove 26 is opened on the top of the fixed box 4. The support assembly 9 is movably installed inside the storage groove 26. The support assembly 9 includes an arc plate 27. A bearing seat is fixedly installed on the arc plate 27. A threaded column 28 is rotatably installed on the bearing seat. The threaded column 28 is rotatably installed on the fixed box 4. An opening 25 is opened on the fixed seat 2. The opening 25 cooperates with the tearing groove 8. The connecting plate 11 and the adhesive seat 1 are soft plastic plates. The threaded column 28 rotates on the fixed box 4. The rotation pushes the arc plate 27 to move downward and compress and deform the Panax notoginseng gel plate 16.

[0051] When using this device, the adhesive base 1 is first moved twice. Under tension, the adhesive base 1 breaks at the tearing groove 8. After breaking, the width between the adhesive bases 1 can be adjusted for adhesion. When adhering to the skin, one side of the adhesive base 1 is adhered to the skin position first. The other side of the adhesive base 1 moves inside the sliding groove 20 on the fixed base 2 via the slider 12, adjusting the width of the opening between the adhesive bases 1. In addition, when the adhesive base 1 moves on the fixed base 2, the area of ​​the adhesive base 1 can be adjusted. After the adhesive base 1 is adhered, the number of heating mechanisms used is adjusted according to the heating speed required for the Panax notoginseng gel plate 16. When the second heating mechanism 15 is used alone, the threaded column 28 rotates and pushes the arc plate 27 to squeeze the heating mechanism and the Panax notoginseng gel plate 16. After being squeezed, the Panax notoginseng gel plate 16 enters the space between the opening 25 and the adhesive base 1 in an arc shape. As the arc plate 27 descends, one side of the Panax notoginseng gel plate 16 comes into contact with the skin, and the second heating mechanism 15 heats the Panax notoginseng gel plate 16. The structure 15 provides the necessary oxygen support to the second heating mechanism 15 through the air inlet 10 and through hole 18. After the second heating mechanism 15 heats the Panax notoginseng gel plate 16, it accelerates the volatilization of Panax notoginseng. When a heating speed is required, the movable plate 7 is pulled out from the support plate 6. When pulled out, the sealing plate 19 is separated from the horizontal plate 29 through the disconnect groove 31. After separation, the bottom of the first heating mechanism 14 is opened. The space at the bottom of the first heating mechanism 14 is heated after contact with air. After heating, the heat is superimposed with the heat of the second heating mechanism 15 to provide temperature. In addition, the first heating mechanism 14 is used after the second heating mechanism 15 has finished heating, which can provide long-term heating for the Panax notoginseng gel plate 16. After the Panax notoginseng gel plate 16 has dispersed, the arc plate 27 can be moved upward into the storage groove 26. The support plate 6 is used to pull the Panax notoginseng gel plate 16 out from the inside of the fixed box 4. After pulling it out, a new Panax notoginseng gel plate 16 is replaced and reused. The Panax notoginseng gel plate 16 can be replaced and reused multiple times without the adhesive seat 1 separating from the skin.

[0052] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the scope of the invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0053] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A method for preparing a nano-Panax notoginseng gel patch, characterized in that: The preparation method includes the following steps: Step 1: Selecting materials; Step 2: High-energy spheres are ground into nanoparticles; Step 3: Fabricate nano-Panax notoginseng gel patches; Step 4: In vitro rabbit skin test; Step 5: Determine the components of the drug exudate from the patch; Step Six: Toxicology and Safety Studies; Step 7: Filtering; Step 8: Data Analysis; In step two, the nano-sizing process involves using high-energy ball milling to pulverize Panax notoginseng. The microstructure is observed using scanning electron microscopy, and the effects of nano-sizing on the content of ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 are determined by HPLC to identify the optimal ball milling process. In step three, the manufacturing process of the Panax notoginseng gel patch involves: first, examining the adhesion of the patch; second, using a Franz-type transdermal diffusion cell device; third, determining the content of saponins by HPLC; fourth, screening the optimal ratio of nano-Panax notoginseng powder and penetration enhancer; and fifth, optimizing the Panax notoginseng nano-gel patch molding process.

2. A nano-Panax notoginseng gel patch, comprising a patch body, characterized in that: The patch body includes an adhesive base (1), a fixed base (2) is movably mounted on the adhesive base (1), a fixed box (4) is fixedly mounted on the fixed base (2), a support plate (6) is movably mounted inside the fixed box (4), a movable plate (7) is movably mounted on the support plate (6), an adhesive plate (3) is fixedly mounted on the bottom inner wall of the adhesive base (1), a connecting plate (11) is fixedly mounted on the adhesive base (1), a tearing groove (8) is opened between the connecting plates (11), and a slider (12) is fixedly mounted on the connecting plate (11).

3. The nano-Panax notoginseng gel patch according to claim 2, characterized in that: The bottom of the fixed base (2) has a sliding groove (20), the slider (12) is movably installed inside the sliding groove (20), the side of the fixed box (4) has an air inlet (10), and the top of the fixed box (4) is movably installed with a support component (9).

4. The nano-Panax notoginseng gel patch according to claim 2, characterized in that: The first heating mechanism (14), the second heating mechanism (15) and the Panax notoginseng gel plate (16) are fixedly installed on one side of the support plate (6), and the Panax notoginseng gel plate (16) is fixedly installed at the bottom of the second heating mechanism (15).

5. The nano-Panax notoginseng gel patch according to claim 4, characterized in that: The second heating mechanism (15) is installed at the bottom of the first heating mechanism (14), and a partition plate (17) is fixedly installed between the first heating mechanism (14) and the second heating mechanism (15). The partition plate (17) has a through hole (18).

6. The nano-Panax notoginseng gel patch according to claim 5, characterized in that: A horizontal plate (29) is fixedly installed on the inner wall of the partition plate (17), and a sealing plate (19) is installed between the horizontal plates (29). A disconnect groove (31) is opened between the sealing plate (19) and the horizontal plate (29), and one end of the sealing plate (19) is fixed on the movable plate (7).

7. The nano-Panax notoginseng gel patch according to claim 2, characterized in that: A limiting component (13) is movably installed on the side of the support plate (6). The limiting component (13) includes a groove (21). The groove (21) is opened on the side of the support plate (6). A supporting mechanism (22) is fixedly installed inside the groove (21).

8. The nano-Panax notoginseng gel patch according to claim 7, characterized in that: One end of the support mechanism (22) is fixedly installed with a locking bead (23), and a locking hole (24) is movably installed on one side of the locking bead (23). The locking hole (24) is opened on the inner wall of the cavity (5).

9. The nano-Panax notoginseng gel patch according to claim 3, characterized in that: The top of the fixed box (4) has a storage slot (26), and the support component (9) is movably installed inside the storage slot (26). The support component (9) includes an arc plate (27), a bearing seat is fixedly installed on the arc plate (27), and a threaded column (28) is rotatably installed on the bearing seat. The threaded column (28) is rotatably installed on the fixed box (4).

10. The nano-Panax notoginseng gel patch according to claim 2, characterized in that: The fixing seat (2) has an opening (25) that matches the tearing groove (8). The connecting plate (11) and the adhesive seat (1) are made of soft plastic.

Images