Time sequence control method for dry biochemical analyzer, control apparatus, and storage medium

Abstract

The present disclosure provides a time sequence control method for a dry biochemical analyzer, a control apparatus, and a storage medium. The method comprises: dividing one biochemical test into k time sequence control cycles each in the form of nA+B, wherein each time sequence control cycle consists of two parts: nA representing n light measurement preparation parts, and B representing one light measurement part, and multiple reagent card tests are performed in each time sequence control cycle; in a light measurement preparation part of a current time sequence control cycle, controlling a card feeding device to perform card feeding actions required for light measurement on n reagent cards in the current time sequence control cycle, and controlling a sample loading device to perform sample loading actions required for light measurement on n reagent cards in the previous time sequence control cycle; and according to a preset light measurement action required by a biochemical test method in each time sequence control cycle, controlling, in a light measurement part of each time sequence control cycle, a light measurement mechanism to perform light measurement actions on all reagent cards in a reagent card reaction device. The total test duration of multiple items or multiple reagent cards is shortened, thereby improving the test efficiency.

Description

Timing control method, control device and storage medium of dry biochemical analyzer

[0001] Cross Reference to Related Applications

[0002] The present disclosure claims priority to the Chinese patent application No. 202410962435.8, filed on July 18, 2024, entitled "Timing control method, control device and storage medium of dry biochemical analyzer", the entire contents of which are incorporated by reference into the present disclosure. TECHNICAL FIELD

[0003] The present disclosure relates to the technical field of biochemical detection devices, in particular to a timing control method, a control device and a storage medium of a dry biochemical analyzer. BACKGROUND

[0004] A dry biochemical analyzer is an analyzer for clinical chemical testing using solid-phase carrier reagents. By adding a body fluid sample (such as serum, urine, etc.) on a dry reagent card, a biochemical reaction occurs with the reagent card, causing a change in the emission optical density, thereby quantitatively measuring the concentration of a specific component in the sample.

[0005] In related technologies, one sample to be tested has multiple detection items, each detection item corresponds to one reagent card. In order to take into account the detection requirements of each detection item and ensure that each reagent card experiences the same detection process and time from card feeding to card ejection, timing control usually adopts a serial design, and each detection item is executed in the same detection order.

[0006] However, using the above timing control method, the detection completion time of each detection item is sequentially and incrementally delayed, resulting in a significant increase in the total time of multi-item detection.

[0007] SUMMARY

[0008] Therefore, the embodiments of the present disclosure provide a timing control method, a control device and a storage medium of a dry biochemical analyzer to shorten the total time of multi-item or multi-reagent card detection and improve the detection efficiency.

[0009] In a first aspect, the embodiments of the present disclosure provide a timing control method of a dry biochemical analyzer, applied to a control device in the dry biochemical analyzer, the dry biochemical analyzer further comprising a reagent card reaction device, a card feeding device, a sample adding device and a light measurement mechanism; the control device is respectively connected with the card feeding device, the sample adding device and the light measurement mechanism for control, and the method comprises:

[0010] The one-time biochemical detection is divided into k time control cycles in the form of nA+B, each time control cycle is composed of two parts, nA is n light preparation parts, B is 1 light part, each time control cycle performs multiple reagent card detections, the multiple reagent cards perform different biochemical detection items, k and n are positive integers greater than 1;

[0011] In the light preparation part of the current time control cycle, the card feeding device is controlled to perform the card feeding action required for light detection of the n reagent cards of the current time control cycle, and the sample adding device is controlled to perform the sample adding action required for light detection of the n reagent cards of the previous time control cycle;

[0012] Each time control cycle controls the light detection mechanism to perform light detection action on all reagent cards in the reagent card reaction device according to the preset light detection action required by the biochemical detection method in the light part of each time control cycle.

[0013] In an optional embodiment, the control of the card feeding device to perform the card feeding action required for light detection of the n reagent cards of the current time control cycle and the control of the sample adding device to perform the sample adding action required for light detection of the n reagent cards of the previous time control cycle in the light preparation part of the current time control cycle comprises:

[0014] In the light preparation part of the current time control cycle, the card feeding device is controlled to perform the card feeding action required for light detection of the n reagent cards of the current time control cycle, and the sample adding device is controlled to perform the sample adding action required for light detection of the n reagent cards of the previous time control cycle when the preheating temperature of the n reagent cards of the previous time control cycle reaches the target temperature.

[0015] In an optional embodiment, the method further comprises:

[0016] If the preheating temperature of the n reagent cards of the previous time control cycle does not reach the target temperature, wait until the preheating temperature of the n reagent cards of the previous time control cycle reaches the target temperature, and in the light preparation part of the next time control cycle when the target temperature is reached, control the sample adding device to perform the sample adding action on the n reagent cards of the previous time control cycle.

[0017] In an optional embodiment, the control of the card feeding device to perform the card feeding action required for light detection of the n reagent cards of the current time control cycle comprises:

[0018] Control the card feeding device to push the n reagent cards of the current time control cycle into the multiple hole positions in the reagent card reaction device respectively.

[0019] In an optional embodiment, the dry biochemical analyzer further comprises a card ejecting device connected with the control device, and the method further comprises:

[0020] If the number of times of light measurement of the target reagent card in the reagent card reaction device reaches the preset number of times of light measurement after sample addition, in the light measurement preparation part of the next time sequence control cycle reaching the preset number of times of light measurement, the card ejecting device is controlled to eject the target reagent card from the corresponding hole position.

[0021] In an optional embodiment, the method further comprises:

[0022] In the light measurement preparation part of the next time sequence control cycle after the target reagent card is ejected, the card feeding device is controlled to feed a new reagent card into the corresponding hole position.

[0023] In an optional embodiment, the method further comprises:

[0024] The card feeding time of the card feeding device, the sample adding time of the sample adding device, the card ejecting time of the card ejecting device, and the total light measurement time of the light measurement mechanism are obtained.

[0025] The maximum value among the card feeding time, the sample adding time, and the card ejecting time is determined as the light measurement preparation time.

[0026] The k is determined according to the n, the light measurement preparation time, the total light measurement time, the preset biochemical reaction time corresponding to the biochemical detection, and the time for the preheating temperature of the reagent card to reach a target temperature.

[0027] In an optional embodiment, the determination of the k according to the n, the light measurement preparation time, the total light measurement time, the preset biochemical reaction time corresponding to the biochemical detection, and the time for the preheating temperature of the reagent card to reach a target temperature comprises:

[0028] The sum of the preset biochemical reaction time and the time for the preheating temperature of the reagent card to reach a target temperature is calculated.

[0029] The each time sequence control cycle is calculated according to the n, the light measurement preparation time, and the total light measurement time.

[0030] The k is determined according to the sum and the each time sequence control cycle.

[0031] In a second aspect, the embodiments of the present disclosure further provide a control device, comprising a processor, a memory, and a bus, the memory stores machine readable instructions executable by the processor, when the control device is running, the processor and the memory communicate through the bus, and the processor executes the machine readable instructions to perform the method of any one of the first aspect.

[0032] In a third aspect, the embodiments of the present disclosure further provide a computer readable storage medium, which stores a computer program. When the computer program is run by a processor, the method in any one of the first aspect is executed.

[0033] The present disclosure provides a timing control method, a control device and a storage medium of a dry biochemical analyzer. The method comprises: dividing one biochemical detection into k timing control cycles in the form of nA+B, each timing control cycle consisting of two parts, nA being n light measurement preparation parts, and B being one light measurement part, performing multiple reagent card detections in each timing control cycle, in the light measurement preparation part of the current timing control cycle, controlling the card feeding device to perform the card feeding action required for light measurement of n reagent cards in the current timing control cycle, and controlling the sample feeding device to perform the sample feeding action required for light measurement of n reagent cards in the previous timing control cycle, and in each timing control cycle, according to the preset light measurement action required by the biochemical detection method, controlling the light measurement mechanism to perform light measurement action on all reagent cards in the reagent card reaction device in the light measurement part of each timing control cycle. The total time length of multi-item or multi-reagent card detection is shortened, and the detection efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the following will briefly introduce the drawings needed to be used in the embodiments. It should be understood that the following drawings only show some embodiments of the present disclosure, and therefore should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0035] FIG. 1 is a multi-layer dry reagent thin layer of a dry reagent card made on a transparent support substrate;

[0036] FIG. 2 is a first AMYL detection reaction curve during light measurement;

[0037] FIG. 3 is a second AMYL detection reaction curve during light measurement;

[0038] FIG. 4 is a schematic diagram of a dry biochemical analyzer;

[0039] FIG. 5 is a schematic diagram of the existing timing control of the dry biochemical analyzer;

[0040] FIG. 6 is a flowchart of a timing control method of a dry biochemical analyzer according to an embodiment of the present disclosure;

[0041] FIG. 7 is a schematic diagram of the timing control of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0042] FIG. 8 is a flow diagram of a timing control method of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0043] FIG. 9 is a flow diagram of a timing control method of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0044] FIG. 10 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0045] FIG. 11 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0046] FIG. 12 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0047] FIG. 13 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0048] FIG. 14 is a schematic diagram of light measurement according to an embodiment of the present disclosure;

[0049] FIG. 15 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0050] FIG. 16 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0051] FIG. 17 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0052] FIG. 18 is a schematic diagram of card feeding according to an embodiment of the present disclosure;

[0053] FIG. 19 is a schematic diagram of light measurement according to an embodiment of the present disclosure;

[0054] FIG. 20 is a schematic diagram of sample adding according to an embodiment of the present disclosure;

[0055] FIG. 21 is a schematic diagram of light measurement according to an embodiment of the present disclosure;

[0056] FIG. 22 is a schematic diagram of sample adding according to an embodiment of the present disclosure;

[0057] FIG. 23 is a schematic diagram of light measurement according to an embodiment of the present disclosure;

[0058] FIG. 24 is a schematic diagram of card feeding, sample adding and card returning according to an embodiment of the present disclosure;

[0059] FIG. 25 is a flow diagram of a timing control method of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0060] FIG. 26 is a schematic diagram of a reaction curve according to an embodiment of the present disclosure;

[0061] FIG. 27 is a schematic diagram of a reaction curve after time alignment according to an embodiment of the present disclosure;

[0062] Fig. 28 is a schematic diagram of a specific dry biochemical analyzer according to an embodiment of the present disclosure;

[0063] Fig. 29 is a schematic diagram of timing control of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0064] Fig. 30 is a schematic diagram of timing control of the dry biochemical analyzer according to an embodiment of the present disclosure;

[0065] Fig. 31 is a schematic diagram of the structure of the control device according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0066] In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure clearer, the following will be combined with the accompanying drawings for the embodiments of the present disclosure to clearly and completely describe the technical solutions of the embodiments of the present disclosure. Obviously, the described embodiments are only a part of the embodiments of the present disclosure, rather than all the embodiments. The components of the embodiments of the present disclosure described and shown in the accompanying drawings can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present disclosure provided in the accompanying drawings is not intended to limit the scope of the claimed present disclosure, but only represents selected embodiments of the present disclosure. Based on the embodiments of the present disclosure, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present disclosure.

[0067] It should be noted that: similar reference numerals and letters represent similar items in the following drawings, therefore, once an item is defined in one drawing, it does not need to be further defined and explained in the subsequent drawings, and in addition, the terms "first", "second", "third" and the like are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0068] Before introducing the scheme, first, the principle and structure of the dry biochemical analyzer are described:

[0069] The principle of the dry biochemical analyzer is that the body fluid sample (such as serum, urine, etc.) is added on the dry reagent card, the measured substance in the sample reacts with the components on the reagent card to cause the color change of the reagent card, i.e. the change of the reflected light density. Through periodic measurement of the reflected light density of the reagent card at a specific wavelength after adding the sample within a fixed reaction time, the reaction curve of the sample within the entire reaction time is finally drawn. According to the reaction curve, the change value or rate of the reflected light density can be obtained, and then the concentration or biological activity of the measured substance in the sample is obtained by corresponding to the calibration curve.

[0070] Figure 1 is a multi-layer dry reagent thin layer made on a transparent support substrate of a dry reagent card, a typical reagent thin layer from top to bottom is diffusion layer, filter layer, reagent layer and color development layer, when detecting a sample, the temperature of the dry reagent card is always heated and stabilized at the optimum reaction temperature of about 37°, the carrier mechanism of the automatic equipment that completes this necessary action is usually disc-shaped, called reaction disc (i.e. reagent card disc). After preheating, a certain amount of body fluid sample is added to the surface of the reagent detection card on the diffusion layer, the body fluid sample spreads horizontally in a circular area on this layer to increase the contact area of the subsequent body fluid sample with the reagent and improve the reaction speed, at the same time, the body fluid sample also penetrates downward to the filter layer, after the interference of the body fluid sample is filtered out by the filter layer, it penetrates downward to the reagent layer and reacts with the dry reagent components solidified therein, the reaction product will produce absorption to light of a specific spectral range, the reaction product continues to penetrate downward to the color development layer and is fixed, finally, the color change of the reagent thin layer can be observed from the transparent support substrate, the degree or rate of color change can reflect the concentration of the measured substance, by measuring the color change of the dry reagent card, the concentration or biological activity of the measured substance in the body fluid sample can be determined.

[0071] The visual subjective perception of the color change of the dry reagent card can be objectively and quantitatively detected by measuring the reflectance density, for example, the reaction of the dry reagent amylase (AMYL) project, Figure 2 is the AMYL detection reaction curve 1 during the light measurement, Figure 3 is the AMYL detection reaction curve 2 during the light measurement, as shown in Figure 2, the horizontal axis is the time axis of the reflectance density collection with a fixed period of time during the light measurement, i.e. detection time (unit: s), the vertical axis is the reflectance density (unitless), connecting the periodic reflectance density forms the AMYL project detection reaction curve.

[0072] As shown in Figure 3, the horizontal axis is the detection time (unit: s), the vertical axis is the emission density (unitless), in the detection linear region, the change rate of the reflectance density per unit time in this region is calculated based on the linear region fitting line (marked as a dashed line), and the concentration of the measured substance in the body fluid sample can be obtained by substituting it into the corresponding calibration curve equation.

[0073] It should be noted that the change rate of the reflectance density per unit time is calculated in terms of the change per minute, and it is also fitted with the concentration, so the more the periodic test reflectance density in each minute, the more beneficial to the calibration concentration fitting and the final quantitative calculation.

[0074] Figure 4 is a schematic diagram of a dry biochemical analyzer, as shown in Figure 4, including: a reagent card chuck for meeting the incubation temperature 37℃ condition, a card feeding module for putting the reagent card into the reagent card chuck, a card ejecting module for pushing the reagent card into the waste bin, a sample adding module for adding the sample to the reagent card, and a reflectance photometer for measuring the reflectance density. The dry biochemical analyzer can further include a control device for controlling the card feeding device, the card ejecting device, the sample adding device, and the reflectance photometer to perform the timing control method of the dry biochemical analyzer, and the control device can be a host computer.

[0075] In the above method, the number of hole positions of the reagent card chuck is m, the reagent card chuck can rotate clockwise or counterclockwise around the center, the reflectance photometer and the sample adding module are fixedly arranged, but the specific positions are not limited, and the structures are only schematically shown in the figure. The card feeding module and the card ejecting module each include a card pushing plate, the card feeding module pushes the reagent card into the reagent card chuck through the card pushing plate, and the card ejecting module pushes the reagent card into the waste bin through the card pushing plate.

[0076] In the above method, one sample to be tested has multiple detection items, each detection item corresponds to one reagent card, and Figure 5 is a schematic diagram of the existing timing control of the dry biochemical analyzer. As shown in Figure 5, the first reagent card is pushed into the reaction disc, while the first reagent card is preheated, the reaction disc is rotated and the second reagent card is pushed in, the first reagent card that has completed preheating is rotated to the reflectance photometer for light measurement (i.e., measurement of reflectance density), after the light measurement is completed, the first reagent card is rotated to the position of the sample adding module, and the sample is added dropwise to the preheated first reagent card. The time for light measurement is counted from the completion of the first preheating, the first reagent card is rotated to the position of the reflectance photometer for light measurement according to the fixed light measurement period of the instrument, and the first optical data (i.e., reflectance density) after the sample addition is obtained. At this time, the second reagent card is being preheated, the third reagent card is then pushed into the reaction disc, the second reagent card that has completed the preheating action is subjected to initial light measurement, and at this time, the first reagent card also reaches the second light measurement period. The light measurement is sequentially performed on the first reagent card and the second reagent card, the second reagent card that has completed the initial light measurement is transferred to the sample adding module for sample adding action, and the light measurement is sequentially performed on the first reagent card and the second reagent card when the light measurement period arrives. According to the above periodic action, the fourth reagent card is pushed in, and the subsequent reagent cards are sequentially pushed in according to the process.

[0077] In the timing control method, the time interval between each reagent card is consistent, which is the light measurement period in the figure, and the time for outputting the result is sequentially and sequentially increased. According to the period of 30 seconds, the result of the first reagent card is outputted at 7 minutes, the result of the second reagent card is outputted at 7 minutes and 30 seconds, and the result of the 20th reagent card is outputted at 16 minutes and 30 seconds.

[0078] It can be seen that the existing timing control adopts a serial design, each detection item is executed in the same detection order, so that the detection completion time of each detection item is sequentially delayed and increased, resulting in a significant increase in the total time of multi-item photometry.

[0079] In addition, the dry photometry time is usually 5 minutes from sample addition to reaction completion, so at least 15 seconds or 30 seconds of photometry cycle is required to obtain sufficient amount of detection data, but this cycle time will limit the number of tests of the entire reagent cartridge, because the number of tests of the reaction disc increases as the amount of detection data increases, which will inevitably increase the area or circumference of the reaction disc, and the cycle test time is fixed, so the increased reaction disc will inevitably increase the difficulty and requirement of other actions such as photometry and sample addition.

[0080] Based on this, since biochemical detection is mostly multi-item joint detection, because a single item detection anomaly does not represent a clinical problem, multi-item joint detection has become a trend, based on this, the timing control method for a dry biochemical analyzer is provided, which can shorten the total time of multi-item or multi-reagent card detection, and improve the detection effect to meet the detection requirements.

[0081] FIG. 6 is a flowchart of a timing control method for a dry biochemical analyzer according to an embodiment of the present disclosure, the execution subject of the embodiment can be a control device in the dry biochemical analyzer, such as a host computer, wherein the dry biochemical analyzer further comprises a reagent card reaction device, a card feeding device, a sample adding device, and a photometry mechanism, and the control device is in control connection with the card feeding device, the sample adding device, and the photometry mechanism.

[0082] The control device can be a host computer, the reagent card reaction device can be a reagent cartridge, and the photometry mechanism can be a reflection photometer, for specific structure, please refer to the embodiment of FIG. 4, of course, this is only an exemplary structure, and the specific structure and form of the dry biochemical analyzer are not particularly limited in the embodiment.

[0083] One biochemical detection is divided into k time sequence control cycles of nA+B form, each time sequence control cycle consists of two parts, nA is n photometry preparation parts, and B is one photometry part, each time sequence control cycle performs multiple reagent card detections, and multiple reagent cards perform different biochemical detection items, k and n are both positive integers greater than 1.

[0084] n is the number of actions required for repeated and superimposed photometry in one time sequence control cycle, that is, the number of reagent cards required for the same photometry in one time sequence control cycle, k represents the number of cycle loops, that is, the number of time sequence control cycles, and the actions required for photometry can include card feeding actions and sample adding actions.

[0085] Each timing control cycle performs multiple reagent card detection, different reagent cards have different detection reagents, and different biochemical detection items are performed after adding body fluid samples to different reagent cards.

[0086] As shown in FIG. 6, the method can include:

[0087] S101, in the light measurement preparation part of the current timing control cycle, control the card feeding device to perform the card feeding action required for light measurement on the n reagent cards of the current timing control cycle, and control the sample adding device to perform the sample adding action required for light measurement on the n reagent cards of the previous timing control cycle.

[0088] Wherein, the card feeding action required for light measurement can be understood as pushing the reagent card into the reagent card reaction device, and the sample adding action required for light measurement can be understood as adding a body fluid sample to the reagent card, which can be serum, urine, etc.

[0089] In the light measurement preparation part of the current timing control cycle, control the card feeding device to perform the card feeding action required for light measurement on the n reagent cards of the current timing control cycle, to push the n reagent cards of the current timing control cycle into the reagent card reaction device, and control the sample adding device to perform the sample adding action required for light measurement on the n reagent cards of the previous timing control cycle, to add a body fluid sample to the n reagent cards of the previous timing control cycle.

[0090] It can be understood that in the light measurement preparation part of the previous timing control cycle, the card feeding module controls the n reagent cards of the previous timing control cycle to perform the card feeding action, so as to push the n reagent cards of the previous timing control cycle into the reagent card reaction device.

[0091] Taking the reagent card reaction device as an example, the control device controls the reagent card disc to rotate, and sequentially rotates the multiple reagent cards of the current timing control cycle to the position of the card feeding device, and sequentially rotates the multiple reagent cards of the previous timing control cycle to the position of the sample adding device, and then controls the card feeding device to sequentially perform the card feeding action on the multiple reagent cards of the current timing control cycle, and controls the sample adding device to sequentially perform the sample adding action on the multiple reagent cards of the previous timing control cycle. Based on this, the overall structure layout of the dry biochemical analyzer needs to consider the separate layout of the devices performing different light measurement preparation actions, so as to ensure that these devices can operate simultaneously without interfering with each other within the same time period.

[0092] S102, each timing control cycle controls the light measurement mechanism to perform light measurement action on all reagent cards in the reagent card reaction device in the light measurement part of each timing control cycle according to the preset light measurement action required by the biochemical detection method.

[0093] In each time sequence control period, the light measurement mechanism can be controlled to perform light measurement on all reagent cards in the reagent card reaction device according to a preset light measurement action required by the biochemical detection method. The light measurement action can include measuring the reflectance density.

[0094] In an optional embodiment, according to the light measurement algorithm, a target time sequence control period can be determined from the k time sequence control periods, in which the light measurement mechanism is controlled to perform light measurement on all reagent cards in the reagent card reaction device. The target time sequence control period is the period in which the light measurement action is performed according to the light measurement algorithm, and can be determined according to the detection method required by the reagent card item to be tested, which is not particularly limited in the present embodiment.

[0095] The all reagent cards in the reagent card reaction device include the n reagent cards in the current time sequence control period and the n reagent cards in the previous time sequence control period.

[0096] For example, the reagent card reaction device is a reagent card disc, the control device controls the rotation of the reagent card disc, and all reagent cards in the reagent card disc are rotated to the light measurement mechanism one by one, so that the light measurement mechanism performs light measurement on all reagent cards one by one. The control device can obtain a reaction curve according to the light measurement results (i.e., the reflectance density) of the light measurement mechanism. In the linear detection region of the reaction curve, the change rate of the reflectance density per unit time is solved, and the change rate is substituted into the calibration curve equation to obtain the concentration or biological activity of the analyte in the body fluid sample under different biochemical detection items.

[0097] For example, the previous time sequence control period is the first time sequence control period, and the current time sequence control period is the second time sequence control period. The n reagent cards in the first time sequence control period are the first to fourth reagent cards, and the n reagent cards in the second time sequence control period are the fifth to eighth reagent cards.

[0098] FIG. 7 is a schematic diagram of the time sequence control of the dry biochemical analyzer according to an embodiment of the present disclosure. As shown in FIG. 7, in the light measurement preparation part of the first time sequence control period, the first to fourth reagent cards are pushed into the reagent card reaction device, and in the light measurement part of the first time sequence control period, light measurement is performed on the first to fourth reagent cards. In the light measurement preparation part of the second time sequence control period (i.e., nxt A ), the fifth to eighth reagent cards are pushed into the reagent card reaction device, and in the light measurement part of the second time sequence control period (i.e., tx B ), light measurement is performed on the first to eighth reagent cards in the reagent card reaction device. The subsequent time sequence control periods are similar, and the process is repeated until the light measurement action in the kth time sequence control period is completed.

[0099] wherein the measurement preparation time required by the measurement preparation part is represented as nxt A wherein the measurement time required by the measurement part is represented as t B。

[0100] In the embodiment, by fixing the timing control period, the measurement preparation part of the timing control period of the dry biochemical analyzer is effectively utilized, different measurement preparation actions are completed in parallel, the action sequence of each device is scientifically planned, and the measurement action of the reagent card of different timing control periods is synchronously performed in the measurement part of the timing control period. The total time length of multi-item or multi-reagent card detection is shortened, and the detection efficiency is improved.

[0101] FIG. 8 is a flowchart of a timing control method of a dry biochemical analyzer according to an embodiment of the present disclosure. As shown in FIG. 8, in an optional embodiment, the step S101, in the measurement preparation part of the current timing control period, the card feeding device is controlled to perform the card feeding action required for the measurement of the n reagent cards of the current timing control period, and the sample adding device is controlled to perform the sample adding action required for the measurement of the n reagent cards of the previous timing control period, can include:

[0102] S201, in the measurement preparation part of the current timing control period, the card feeding device is controlled to perform the card feeding action for the n reagent cards of the current timing control period, and when the preheating temperature of the n reagent cards of the previous timing control period reaches the target temperature, the sample adding device is controlled to perform the sample adding action for the n reagent cards of the previous timing control period.

[0103] In the measurement preparation part of the current timing control period, the card feeding device is controlled to perform the card feeding action for the n reagent cards of the current timing control period to push the n reagent cards of the current timing control period into the reagent card reaction device, and the preheating temperature of the n reagent cards of the previous timing control period pushed into the reagent card reaction device in the measurement preparation part of the previous timing control period is detected. If the preheating temperature of the n reagent cards of the previous timing control period reaches the target temperature, the sample adding device is controlled to perform the sample adding action for the n reagent cards of the previous timing control period in the measurement preparation part of the current timing control period.

[0104] Wherein the reagent card reaction device is further used for preheating the reagent card. In the case that the preheating speed of the reagent card reaction device is very fast, that is, the preheating temperature of the n reagent cards of the previous timing control period reaches the target temperature in the previous timing control period, the sample adding action can be performed for the n reagent cards of the previous timing control period in the measurement preparation part of the current timing control period. The target temperature is a temperature suitable for biochemical reaction, for example, 37°.

[0105] In the embodiment, the preheating temperature of the reagent card reaches the target temperature before sample adding, and the detection reagent of the reagent card and the body fluid sample can be fully reacted after sample adding, thereby improving the light measurement accuracy.

[0106] In an optional embodiment, the method can further include:

[0107] S202, if the preheating temperature of the n reagent cards in the previous timing control period does not reach the target temperature, waiting until the preheating temperature of the n reagent cards in the previous timing control period reaches the target temperature, and in the light measurement preparation part of the next timing control period when the target temperature is reached, controlling the sample adding device to perform sample adding action on the n reagent cards in the previous timing control period.

[0108] If the preheating temperature of the n reagent cards in the previous timing control period does not reach the target temperature, waiting until the preheating temperature of the n reagent cards in the previous timing control period reaches the target temperature, that is, when the preheating temperature of the n reagent cards in the previous timing control period does not reach the target temperature, no sample adding action is performed on the n reagent cards in the previous timing control period, but in the light measurement part of the current timing control period, the n reagent cards in the previous timing control period are normally executed light measurement action. In the light measurement preparation part of the next timing control period when the target temperature is reached, the sample adding device is controlled to perform sample adding action on the n reagent cards in the previous timing control period.

[0109] For example, the n reagent cards in the first timing control period can reach the target temperature in the third timing control period, and the sample adding action is performed on the n reagent cards in the first timing control period in the light measurement preparation part of the fourth timing control period, wherein in the light measurement part of the second timing control period, the third timing control period, and the fourth timing control period, the light measurement mechanism is controlled to normally perform light measurement action on the n reagent cards in the first timing control period.

[0110] In the embodiment, by fixing the timing control period, the reagent card heating of the reagent card reaction device of the dry biochemical analyzer is effectively utilized, different light measurement preparation actions are completed in parallel in the light measurement preparation part of the timing control period, the action sequence of each device is scientifically planned, and the light measurement action of the reagent cards in different timing control periods is synchronously performed in the light measurement part of the timing control period. The total time length of multi-project or multi-reagent card detection is shortened, and the detection efficiency is improved.

[0111] In an optional embodiment, in the step S101, the sample adding action required by the card feeding device to control the n reagent cards in the current timing control period to perform light measurement can include:

[0112] The card feeding device pushes the n reagent cards in the current timing control period into the multiple hole positions in the reagent card reaction device, respectively.

[0113] Pushing the reagent card into the reagent card reaction device can be understood as pushing the reagent card into a hole position of the reagent card reaction device, and the control card feeding device pushes n reagent cards of the current time sequence control period into multiple hole positions of the reagent card reaction device respectively, and one hole position can push one reagent card.

[0114] Similarly, pushing n reagent cards of the previous time sequence control period into the reagent card reaction device can be understood as pushing n reagent cards of the previous time sequence control period into n hole positions of the reagent card reaction device respectively.

[0115] Figure 9 is a flowchart of a time sequence control method of a dry biochemical analyzer provided by an embodiment of the present disclosure. In an optional implementation, the dry biochemical analyzer further includes a card ejecting device connected to the control device. As shown in Figure 9, the method can further include:

[0116] S301, if the number of light measurements of the target reagent card in the reagent card reaction device after sample addition reaches the preset number of light measurements, in the light measurement preparation part of the next time sequence control period reaching the preset number of light measurements, the control card ejecting device ejects the target reagent card from the corresponding hole position.

[0117] The corresponding hole position is the hole position of the target reagent card in the reagent card reaction device.

[0118] If the number of light measurements of the target reagent card after sample addition reaches the preset number of light measurements, in the light measurement preparation part of the next time sequence control period reaching the preset number of light measurements, the control card ejecting device ejects the target reagent card from the corresponding hole position, wherein the dry biochemical analyzer can further include a waste bin, and the control card ejecting device pushes the target reagent card from the corresponding hole position into the waste bin to eject the target reagent card from the corresponding hole position.

[0119] The preset number of light measurements is determined by the preset biochemical reaction time and the time sequence control period, and the preset number of light measurements = preset biochemical reaction time / time sequence control period, that is, the light measurement action is performed on the target reagent card within the preset biochemical detection time, and after the preset biochemical detection time is reached, the target reagent card is controlled to be ejected from the reagent card reaction device to avoid occupying the hole position resource of the reagent card reaction device.

[0120] For example, the preset biochemical reaction time is 5 minutes, and the timing control period is 20 seconds, and the preset light measurement times can be 300 seconds / 20 seconds = 15 times, that is, in order to ensure that the biochemical reaction is complete after sample addition, 15 times of timing control period are required, that is, 15 times of light measurement actions are performed on the reagent card after sample addition, and the sample addition time difference between the n reagent cards in each timing control period can be corrected by an algorithm to obtain consistent results, so as to eliminate the influence of the action sequence time difference.

[0121] The light measurement action can further include a reagent card returning action.

[0122] In an optional embodiment, the method can further include:

[0123] S302, in the light measurement preparation part of the next timing control period after the target reagent card is returned, the card feeding device is controlled to push the new reagent card into the corresponding hole position.

[0124] In the light measurement preparation part of the next timing control period after the target reagent card is returned, the card feeding device is controlled to push the new reagent card into the corresponding hole position, which is the hole position of the target reagent card in the reagent card reaction device, and the number of the new reagent card is less than or equal to the number of the target reagent card.

[0125] It can be understood that the number of hole positions of the reagent card reaction device is m, if it is required to continuously detect more than the number of hole positions of the reagent card reaction device for a single sample for multiple biochemical detection projects, the target reagent card can be returned in sequence after the light measurement times of the target reagent card after sample addition reach the preset light measurement times, and the new reagent card can be arranged to enter the corresponding hole position in the reagent card reaction device.

[0126] The light measurement preparation action corresponds to the device such as the card feeding device, the sample adding device, and the reagent card returning device. When the reagent card reaction device stops rotating, other action devices can perform discrete actions such as card feeding action, sample adding action, and reagent card returning action, or can perform combined actions of these discrete actions. For example, some dry biochemical analyzers have a reagent card information scanning function, which can be combined with the card feeding action to scan the reagent card information while feeding the card, but it is required to be completed in the light measurement preparation part, and after the light measurement preparation action is completed, the reagent card reaction device can be controlled to rotate in a set direction.

[0127] The reagent card reaction device is taken as the reagent card chuck, and the light measuring mechanism is taken as the reflection photometer as an example. For k nA+B, for example, k=3, n=4, 8 biochemical detection items, one reagent card for one biochemical detection item, Fig. 10 is a schematic diagram of card feeding one provided by an embodiment of the present disclosure, Fig. 11 is a schematic diagram of card feeding two provided by an embodiment of the present disclosure, Fig. 12 is a schematic diagram of card feeding three provided by an embodiment of the present disclosure, and Fig. 13 is a schematic diagram of card feeding four provided by an embodiment of the present disclosure. As shown in Figs. 10-13, in the light measuring preparation part of the previous time sequence control cycle, the card feeding device pushes in 4 reagent cards (i.e., reagent card 1 to reagent card 4) in turn.

[0128] Fig. 14 is a schematic diagram of light measurement one provided by an embodiment of the present disclosure. As shown in Fig. 14, in the light measurement part of the previous time sequence control cycle, 1 light measurement is performed on the 4 reagent cards.

[0129] Fig. 15 is a schematic diagram of card feeding five provided by an embodiment of the present disclosure, Fig. 16 is a schematic diagram of card feeding six provided by an embodiment of the present disclosure, Fig. 17 is a schematic diagram of card feeding seven provided by an embodiment of the present disclosure, and Fig. 18 is a schematic diagram of card feeding eight provided by an embodiment of the present disclosure. As shown in Figs. 15-18, in the light measuring preparation part of the current time sequence control cycle, 4 reagent cards (i.e., reagent card 5 to reagent card 8) are pushed in in turn, and the 4 reagent cards (i.e., reagent card 1 to reagent card 4) pushed in by the previous time sequence control cycle are respectively added with samples.

[0130] Fig. 19 is a schematic diagram of light measurement two provided by an embodiment of the present disclosure. As shown in Fig. 19, in the light measurement part of the current time sequence control cycle, 1 light measurement is performed on the 8 reagent cards (i.e., reagent card 1 to reagent card 8) in the reagent card chuck. At this time, the 8 reagent cards in the reagent card chuck have all completed card feeding and light measurement.

[0131] It can be understood that when k=3, n=4, the layout of the sample adding device and the card feeding device needs to meet the distance of 4 hole positions. Taking the above 8 reagent cards as an example, while the sample adding device adds a sample to the first reagent card (i.e., reagent card 1), the card feeding device pushes the fifth reagent card (i.e., reagent card 5) into the reagent card chuck. In this way, while the first four reagent cards (i.e., reagent card 1 to reagent card 4) are added with samples, the last four reagent cards (i.e., reagent card 5 to reagent card 8) can be pushed in.

[0132] It is worth noting that Figs. 10-19 are only used to describe the functions of the sample adding device, the card feeding device, and the card feeding device, and the sample adding device, the card feeding device, and the card feeding device are not locked at the positions shown in Figs. 10-19. In the actual dry biochemical analyzer, the positions of the sample adding device, the card feeding device, and the card feeding device can be adjusted according to the time sequence of the dry biochemical analyzer.

[0133] For example, when the temperature of the reagent cards reaches the target temperature after several time control cycles, Fig. 20 is a schematic diagram of sample adding provided by the embodiment of the present disclosure, as shown in Fig. 20, in the light measurement preparation part of the next time control cycle when the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) reaches the target temperature, the first four reagent cards (i.e. reagent card 1 to reagent card 4) are sequentially added with samples.

[0134] Fig. 21 is a schematic diagram of light measurement provided by the embodiment of the present disclosure, as shown in Fig. 21, in the light measurement part of the next time control cycle when the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) reaches the target temperature, the first four reagent cards (i.e. reagent card 1 to reagent card 4) and the last four reagent cards (i.e. reagent card 5 to reagent card 8) are sequentially measured once.

[0135] In this example, since the interval time for the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) and the last four reagent cards (i.e. reagent card 5 to reagent card 8) to reach the target temperature is one time control cycle, in the next time control cycle when the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) reaches the target temperature, the preheating temperature of the last four reagent cards also reaches the target temperature, Fig. 22 is a schematic diagram of sample adding provided by the embodiment of the present disclosure, Fig. 23 is a schematic diagram of light measurement provided by the embodiment of the present disclosure, as shown in Fig. 22, in the light measurement preparation part of the next time control cycle of the next time control cycle when the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) reaches the target temperature, the last four reagent cards (i.e. reagent card 5 to reagent card 8) are sequentially added with samples, as shown in Fig. 23, in the light measurement part of the next time control cycle of the next time control cycle when the preheating temperature of the first four reagent cards (i.e. reagent card 1 to reagent card 4) reaches the target temperature, the first four reagent cards (i.e. reagent card 1 to reagent card 4) and the last four reagent cards (i.e. reagent card 5 to reagent card 8) are sequentially measured.

[0136] For the eight reagent cards (i.e. reagent card 1 to reagent card 8), the card feeding, preheating, sample adding, and light measurement have all been completed according to the time control cycle, and only the time control method needs to be continuously run until the preset biochemical reaction time is reached, the reaction curve is drawn according to the reflected light density obtained by light measurement, and the concentration or biological activity of the measured substance in the body fluid sample is calculated.

[0137] It is worth noting that the time control mode of the k nA+B mode also has another advantage, since the mode is executed in a loop from the light measurement preparation part, and the compatibility in the light measurement preparation part is extremely high, that is, different light measurement actions can be executed synchronously in the light measurement preparation part.

[0138] Figure 24 is a schematic diagram of card feeding, sample adding and card withdrawing provided by the embodiment of the present disclosure. As shown in Figure 24, in the light measurement preparation part of the timing control cycle, the reagent card in the No. 5 hole position is fed, the reagent card in the No. 4 hole position is added with sample, and the reagent card in the No. 15 hole position is withdrawn.

[0139] In the embodiment, for multiple biochemical detection items, the light measurement preparation part of the timing control cycle of the dry biochemical analyzer is effectively utilized, different light measurement preparation actions are completed in parallel, the action sequence of each device is scientifically planned, and the light measurement actions of the reagent cards in different timing control cycles are synchronously performed in the light measurement part of the timing control cycle. The total detection time of multiple items or multiple reagent cards is shortened, and the detection efficiency is improved.

[0140] Figure 25 is a schematic diagram of the timing control method of the dry biochemical analyzer provided by the embodiment of the present disclosure.

[0141] S401, the feeding time of the card feeding device, the sample adding time of the sample adding device, the withdrawing time of the card withdrawing device and the total light measurement time of the light measurement mechanism are obtained.

[0142] The feeding time is the time required for the card feeding device to push a reagent card into the reagent card reaction device, the sample adding time is the time required for the sample adding device to add sample to a reagent card, the withdrawing time is the time required for the card withdrawing device to withdraw a reagent card from the reagent card reaction device, and the total light measurement time is the time required for the light measurement mechanism to measure the light of all the reagent cards in the reagent card reaction device. For example, if the number of hole positions is m, the total light measurement time is the time required for the light measurement mechanism to measure the light of m reagent cards.

[0143] The total light measurement time of the light measurement module can be determined by the optical performance of the dry biochemical analyzer itself, and the feeding time of the card feeding device, the sample adding time of the sample adding device and the withdrawing time of the card withdrawing device are determined by the performance of the card feeding device, the sample adding device and the card withdrawing device respectively, and are not affected by the optical performance.

[0144] The total light measurement time is t B The total time of testing all the reagent cards in the reagent card reaction device and the required wavelengths is recorded as t B One testing method is to rotate at a constant speed and test each hole position with single wavelength or double wavelength to obtain the time parameters of light measurement of all the hole positions. Another testing method is to sort all the optical testing wavelengths and then rotate one round for each wavelength to obtain the time parameters of light measurement of all the hole positions. Since the detection items are numerous and the reaction principles are different, different wavelengths of light sources are required for detection according to different item requirements. The wavelength data required by the hole position can be obtained from the wavelength data corresponding to all the hole positions for calculation.

[0145] S402, determining the light measurement preparation time according to the maximum value among the card feeding time, the sample adding time and the card withdrawing time.

[0146] The maximum value among the card feeding time, the sample adding time and the card withdrawing time is taken as the light measurement preparation time, and the light measurement preparation time is the maximum time required for the actions performed by one reagent card for light measurement.

[0147] S403, determining k according to n, the light measurement preparation time, the total light measurement time, the preset biochemical reaction time corresponding to biochemical detection and the time for the preheating temperature of the reagent card to reach the target temperature.

[0148] The time for the preheating temperature of the reagent card to reach the target temperature is the time between the card feeding and the sample adding.

[0149] According to n, the light measurement preparation time and the total light measurement time, each timing control period is calculated, wherein the timing control period can be expressed as: nxt A + t B , wherein t A is the light measurement preparation time, t B is the total light measurement time, A represents any one of the card feeding action, the sample adding action and the card withdrawing action, and B represents the light measurement action.

[0150] The sum of the preset biochemical reaction time and the time for the preheating temperature of the reagent card to reach the target temperature is calculated, and k is determined according to the sum and each timing control period, for example, the time for the preheating temperature of the reagent card to reach the target temperature is p, and the preset biochemical reaction time is q, and k is expressed as: (q+p) / (Nxt A + t B ).

[0151] In this embodiment, the timing control method of the dry biochemical analyzer follows the kxt A + t B ) mode, and the kxt A + t B ) mode means that in one timing control period, n A actions and one B action can be simultaneously superimposed, which can be n card feeding actions A and one light measurement action B, or n sample adding actions A and one light measurement action B, and the combination modes are various, as long as t A and t B are greater than or equal to the maximum value of the combined actions, so as to avoid that n A actions and one B action cannot be completed in one timing control period.

[0152] It can be understood that nxt A represents the time for n reagent cards to perform A actions, and taking the sample adding action as the A action, nxt Arepresent the time required for adding samples to n reagent cards. For example, k x (n x t A +t B ) = 300 seconds, the biochemical reaction from sample addition to reaction completion is 5 minutes, that is, 300 seconds, if k x (n x t A +t B ) is less than or greater than 300 seconds, the cycle time cannot be evenly divided when the entire 300-second reaction is completed, and an additional (n x t A +t B ) period of time is required to perform the last light measurement, thereby extending the entire light measurement time.

[0153] The following several parameter modes can be set:

[0154] When k = 10, the (n x tA+tB) mode time sequence control period is 30 seconds;

[0155] When k = 15, the (n x tA+tB) mode time sequence control period is 20 seconds;

[0156] When k = 20, the (n x tA+tB) mode time sequence control period is 15 seconds;

[0157] When k = 30, the (n x tA+tB) mode time sequence control period is 10 seconds.

[0158] It is worth noting that when t A and t B are determined by the performance of the instrument, the value of k and n should be selected as much as possible to preferentially increase the value of n, because only when the value of n is increased, the number of detection items obtained in the same time is more, wherein the value of n can be theoretically an integer greater than or equal to 2, but a too large value of n will require a higher light measurement action for t B time, and all well positions must be measured for corresponding wavelength data in a shorter time, so the selection of the value of n needs to consider the factor of B action time.

[0159] The time sequence control method of the present scheme is used for repeated detection of a single sample, and the four reagent card reaction curves of the time sequence control period are analyzed. FIG. 26 is a schematic diagram of the reaction curve provided by the embodiment of the present disclosure, as shown in FIG. 26, the horizontal coordinate is the detection time (unit: s), and the vertical coordinate is the reflectance density (unitless). Fifteen reflectance densities collected are connected to form four reaction curves, and the four curves are consistent in form, but there are differences in height and front and back at the same time.

[0160] This is because there is a difference in the sample addition time of the four reagent cards, and this time difference has no effect on the card feeding and incubation sequence, but the time interval of sample addition is separated by four tA The time of the same time sequence control cycle, which means that the first reagent card has been added to the sample, and permeated into the reagent layer of the dry sheet to react, the third reagent card or the fourth reagent card may still be in the process of adding sample, wherein t A is the sample adding time.

[0161] After analysis, 15 points on the abscissa are changed to time axis with a time interval of 20 seconds, the default series one (the first reagent card) starts from 0 seconds, and then the start time of series two (the second reagent card) is increased by 1 t A action time interval, the start time of series three (the third reagent card) is increased by 2 t A action time interval, and the start time of series four (the fourth reagent card) is increased by 3 t A action time interval, and then the four series are connected again according to the time axis. FIG. 27 is a schematic diagram of the reaction curve after time alignment provided by the embodiment of the present disclosure, as shown in FIG. 27, the abscissa is the detection time (unit: s), and the ordinate is the reflectance density (unitless). The four reaction curves are highly overlapped, and the highly overlapped reaction curves represent that the whole system of the dry biochemical analyzer is stable, and the photometric result is more reliable.

[0162] Using the time sequence control method of the scheme, if 20 items are detected, only 4 time sequence control cycle times need to be added in the basic time length of 7 minutes to complete all the detection, and 20 detection results can be obtained in 8 minutes and 20 seconds.

[0163] Taking the reagent card reaction device as a reagent card disc and the photometric structure as a reflectance meter as an example, the reagent card disc has 20 hole positions. FIG. 28 is a schematic diagram of a specific dry biochemical analyzer provided by the embodiment of the present disclosure, as shown in FIG. 28, which includes a reagent card disc, a card feeding device, a card ejecting device, a sample adding device, and a reflectance meter.

[0164] Because the turntable structure needs to be turned one position before or after adding sample in order to align the hole position for the next action, the sample adding action needs the longest time, wherein the sample adding action needs 2 seconds, and the other photometric preparation actions need 1 second, so t A may be set to ≥2 seconds.

[0165] Wherein, while the reagent card rotates at a constant speed for one round, the 20 hole positions can be switched to the required light source respectively, and the optical data collection is completed. The interval time between the holes is used to switch the required light source, and the next light source is kept stable. The reagent card rotates for one round in 1 second, and different wavelengths of the 20 hole positions can be obtained at the same time. For the dual-wavelength project, only two rounds of rotation are needed. Therefore, after the compatibility of the dual-wavelength project, the t B Value≥2 seconds.

[0166] Taking the 3x(5A+B)=300 seconds mode as an example, FIG. 29 is a schematic diagram two of the timing control of the dry biochemical analyzer provided by the embodiment of the present disclosure, and FIG. 30 is a schematic diagram three of the timing control of the dry biochemical analyzer provided by the embodiment of the present disclosure, as shown in FIGS. 29-30, the timing vertical axis is the number of hole positions. According to the layout design of the biochemical analyzer itself, one timing control period can execute 5 A and one B of 5 reagent cards, and 20 hole positions are divided into 4 periods to complete, and the 4 periods of 100 seconds of time can rotate for one round and return to the original position. For the total time of 5 minutes of light measurement, 3 rounds can complete the light measurement and return to the original position. The next timing control period after the retraction of the first 5 reagent cards can start the feeding action of the 21st-25th reagent cards, so that the biochemical multi-item detection is faster.

[0167] Wherein, the first hole position pushes in the first reagent card, and the second hole position pushes in the second reagent card. After the retraction of the first 5 reagent cards, the 21st-25th reagent cards are respectively pushed into the first-fifth hole positions, and the others are sequentially deduced.

[0168] By using the above timing control logic and analysis method, the selected detection projects are the multi-point rate method alanine aminotransferase (ALT) project and the end-point method urea nitrogen (BUN) project, to verify the repeatability and accuracy of the clinical results. The reaction curve forms of the reagent cards in different hole positions are highly consistent. The repeatability CV of the multi-point rate method alanine aminotransferase (ALT) project and the end-point method urea nitrogen (BUN) project is less than 5%, and the relative deviation of the accuracy is less than 10%, which meets the requirements of the clinical results.

[0169] FIG. 31 is a structural schematic diagram of a control device provided by the embodiment of the present disclosure, as shown in FIG. 31, the device includes a processor 501, a memory 502 and a bus 503. The memory 502 stores machine readable instructions executable by the processor 501. When the control device is running, the processor 501 and the memory 502 communicate through the bus 503. The processor executes the machine readable instructions to execute the above method.

[0170] The embodiment of the present disclosure also provides a computer readable storage medium, and the computer readable storage medium stores a computer program. When the computer program is executed by a processor, the processor executes the above method.

[0171] In the embodiments of the present disclosure, the computer program, when executed by the processor, can also execute other machine-readable instructions to perform the methods as described in the embodiments. For specific method steps and principles, refer to the description of the embodiments, which will not be described in detail here.

[0172] Finally, it should be noted that the above-described embodiments are only specific embodiments of the present disclosure, which are used to illustrate the technical solutions of the present disclosure, but not to limit the present disclosure. The protection scope of the present disclosure is not limited thereto. Although the present disclosure has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that any modification or easy-to-think change or equivalent replacement of the technical solutions recorded in the foregoing embodiments can be made within the technical range disclosed by the present disclosure by any person skilled in the art. The modification, change or replacement do not make the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present disclosure. All should be covered in the protection scope of the present disclosure. Therefore, the protection scope of the present disclosure should be subject to the protection scope of the claims. Industrial applicability

[0173] The present disclosure provides a timing control method, a control device and a storage medium of a dry biochemical analyzer, the method comprising: one biochemical detection is divided into k timing control cycles in the form of nA+B, each timing control cycle consists of two parts, nA is n light measurement preparation parts, and B is one light measurement part, a plurality of reagent card detections are performed in each timing control cycle, in the light measurement preparation part of the current timing control cycle, the card feeding device is controlled to perform the card feeding action required for light measurement on the n reagent cards of the current timing control cycle, and the sample adding device is controlled to perform the sample adding action required for light measurement on the n reagent cards of the previous timing control cycle, each timing control cycle controls the light measurement mechanism to perform light measurement action on all reagent cards in the reagent card reaction device in the light measurement part of each timing control cycle according to the preset light measurement action required by the biochemical detection method. The total time length of multi-item or multi-reagent card detection is shortened, and the detection efficiency is improved.

Claims

1. A timing control method of a dry biochemical analyzer, characterized by, The application relates to a control device applied to a dry biochemical analyzer, wherein the dry biochemical analyzer further comprises a reagent card reaction device, a card feeding device, a sample adding device and a light measuring mechanism. The control device is connected with the card feeding device, the sample adding device and the light measuring mechanism respectively, and the method comprises the following steps: One biochemical detection is divided into k time sequence control periods in the form of nA+B, each time sequence control period is composed of two parts, nA is n light measuring preparation parts, B is one light measuring part, each time sequence control period performs multiple reagent card detections, the multiple reagent cards perform different biochemical detection items, k and n are positive integers greater than 1; In the light measuring preparation part of the current time sequence control period, the card feeding action required by the light measuring of the n reagent cards in the current time sequence control period is controlled by the card feeding device, and the sample adding action required by the light measuring of the n reagent cards in the previous time sequence control period is controlled by the sample adding device; In each time sequence control period, the light measuring mechanism is controlled to perform the light measuring action on all the reagent cards in the reagent card reaction device in the light measuring part of each time sequence control period according to the preset light measuring action required by the biochemical detection method; The control of the card feeding device to perform the card feeding action required by the light measuring of the n reagent cards in the current time sequence control period and the control of the sample adding device to perform the sample adding action required by the light measuring of the n reagent cards in the previous time sequence control period in the light measuring preparation part of the current time sequence control period comprises the following steps: In the light measuring preparation part of the current time sequence control period, the card feeding action required by the light measuring of the n reagent cards in the current time sequence control period is controlled by the card feeding device, and the sample adding action required by the light measuring of the n reagent cards in the previous time sequence control period is controlled by the sample adding device; The method further comprises the following steps: If the preheating temperature of the n reagent cards in the previous time sequence control period does not reach the target temperature, the preheating temperature of the n reagent cards in the previous time sequence control period is waited until the target temperature is reached, and the sample adding device is controlled to perform the sample adding action on the n reagent cards in the previous time sequence control period in the light measuring preparation part of the next time sequence control period when the target temperature is reached; The control of the card feeding device to perform the card feeding action required by the light measuring of the n reagent cards in the current time sequence control period comprises the following steps: The card feeding device is controlled to push the n reagent cards in the current time sequence control period into multiple hole positions in the reagent card reaction device respectively; The dry biochemical analyzer further comprises a card discharging device connected with the control device, and the method further comprises the following steps: If the light measuring times of the target reagent card in the reagent card reaction device after sample adding reach the preset light measuring times, the card discharging device is controlled to discharge the target reagent card from the corresponding hole position in the light measuring preparation part of the next time sequence control period when the preset light measuring times are reached; The method further comprises the following steps: acquire a card feeding time of the card feeding device, a sample adding time of the sample adding device, a card withdrawing time of the card withdrawing device, and a total light measuring time of the light measuring mechanism; determine a light measuring preparation time according to a maximum value among the card feeding time, the sample adding time, and the card withdrawing time; determine the k according to the n, the light measuring preparation time, the total light measuring time, a preset biochemical reaction time corresponding to the biochemical detection, and a time for a preheating temperature of the reagent card to reach a target temperature; the determining the k according to the n, the light measuring preparation time, the total light measuring time, the preset biochemical reaction time corresponding to the biochemical detection, and the time for the preheating temperature of the reagent card to reach the target temperature, comprises: calculating a sum value of the preset biochemical reaction time and the time for the preheating temperature of the reagent card to reach the target temperature; calculating the each timing control period according to the n, the light measuring preparation time, and the total light measuring time; determining the k according to the sum value and the each timing control period.

2. The method of claim 1, wherein, The method further comprises: controlling the card feeding device to push a new reagent card into the corresponding hole position in a light measuring preparation part of a next timing control period after the target reagent card is withdrawn.

3. A control device, characterized by comprise: a processor, a memory, and a bus, the memory stores machine readable instructions executable by the processor, when a control device is running, the processor and the memory communicate through the bus, the processor executes the machine readable instructions to execute the method of claim 1 or 2.

4. A computer-readable storage medium, characterized in that, The computer readable storage medium stores a computer program, and the computer program is executed by the processor to execute the method of claim 1 or 2.

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