Composition, and food processed product containing same

Abstract

[Problem] The purpose of the present invention is to recover and regenerate all organs and muscles by conducting various studies on identifying a specific method for suppressing aging and maintaining healthy life expectancy, and by activating all of the approximately 37 trillion cells constituting our body. [Solution] This composition comprises reduced coenzyme Q10 (coenzyme Q10) subjected to water solubilization processing, nicotinamide mononucleotide (NMN), pyrroloquinoline quinone (PQQ) or / and 5-aminolevulinic acid (5ALA), and an antioxidant component (polyphenol, flavonoid, vitamins C / E, glutathione), the composition being characterized in that the activity, increase, and functional deterioration suppression of mitochondria are achieved.

Description

Composition and processed food product containing the same

[0001] The present invention relates to compositions for preventing cell deterioration and extending healthy lifespan.

[0002] Even now, the difference between average life expectancy and healthy life expectancy remains at roughly 10 years for both men and women. The inventors of this application aim to realize a society in which people can live as long and healthy lives as possible in the next 10 years. Therefore, they have refocused their attention on the "energy production function of mitochondria," which has been overlooked until now.

[0003] The energy required for human activities is delivered to all cells in the form of ATP (adenosine triphosphate) and consumed there. It is said that 95% of this energy is produced in the mitochondria.

[0004] However, mitochondria also age, deteriorate, and decrease with age (see Patent Document 1, etc.). Because mitochondria are the energy source of all cells, including cardiac muscle cells, brain cells, and immune cells, including organs and muscles, aging, deterioration, and decrease in mitochondria leads to cell deterioration, leading to human "aging."

[0005] Re-table No. 2017-170300

[0006] Therefore, the inventor of the present application conducted extensive research into specific methods for suppressing aging and maintaining a healthy lifespan, and concluded that the most fundamental solution would be to activate all of the approximately 37 trillion cells that make up our bodies, and to regenerate and regenerate all of our organs and muscles.

[0007] We then concluded that the activity of mitochondria, the energy source of all cells, is essential to maintaining and activating the vital activities of all cells, and completed the present invention.

[0008] The first invention of the present application is a composition comprising water-solubilized reduced coenzyme Q10 (coenzyme Q10) and NMN (nicotinamide mononucleotide), which activates mitochondria. The second invention is a composition comprising water-solubilized reduced coenzyme Q10 (coenzyme Q10), PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid), which increases mitochondria. The third invention is a composition comprising water-solubilized reduced coenzyme Q10 (coenzyme Q10) and antioxidants (polyphenols, flavonoids, vitamins C / E, glutathione), which inhibits mitochondrial dysfunction. The fourth invention is a composition comprising water-solubilized reduced coenzyme Q10 (coenzyme Q10), NMN (nicotinamide mononucleotide), PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid), and antioxidant components (polyphenols, flavonoids, vitamins C / E, glutathione), which is characterized by increasing mitochondrial activity and quantity and inhibiting functional decline. The fifth invention is a processed food product characterized by containing the composition according to any one of the first to fourth inventions.

[0009] The present invention as described above has the following effects. (1) A composition that activates mitochondria can be obtained by including water-solubilized reduced coenzyme Q10 (coenzyme Q10) and NMN (nicotinamide mononucleotide). Specifically, in this composition, NMN is metabolized to NAD+ in the body, which transports protons H+ and electrons that serve as fuel for ATP generation in the citric acid cycle within mitochondria. Reduced coenzyme Q10 then transfers the transported protons H+ and electrons to the ATP generator (cytochrome complex), promoting ATP generation. Furthermore, after completing its role, oxidized coenzyme Q10 receives protons H+ and is converted back to its reduced form, leading to the next round of power generation. As a result, mitochondria are activated. (2) A composition that increases mitochondria can be obtained by including water-solubilized reduced coenzyme Q10 (coenzyme Q10) and PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid). In other words, the composition uses PQQ to stimulate mitochondrial regeneration. Furthermore, 5ALA serves as a material for the citrochrome complex, an ATP generator. ATP is generated by electrons transferred by reduced coenzyme Q10, and this energy is used to create new mitochondria. (3) By incorporating water-soluble reduced coenzyme Q10 (coenzyme Q10) and antioxidant ingredients (polyphenols, flavonoids, vitamins C / E, and glutathione), a composition that suppresses mitochondrial dysfunction can be obtained. In other words, there are multiple forms of reactive oxygen species generated as by-products during ATP generation through oxygen respiration in mitochondria, and multiple antioxidant ingredients are combined to suit each. Furthermore, reduced coenzyme Q10 acts as a last resort when the effects of other treatments are ineffective. (4) By containing reduced coenzyme Q10 (coenzyme Q10) that has been water-soluble processed, NMN (nicotinamide mononucleotide), PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid), and antioxidant ingredients (polyphenols, flavonoids, vitamins C / E, glutathione), a composition can be obtained that promotes mitochondrial activity and increase in quantity and inhibits functional decline.In other words, mitochondria can be activated and increased, and at the same time, they can be protected from reactive oxygen species, resulting in sufficient ATP production in mitochondria and extending healthy lifespan. (5) By incorporating the compositions of the first to fourth inventions into processed food products, the effects of (1) to (4) above can be obtained simply by ingesting the processed food products, which is convenient.

[0010] 1 is an explanatory diagram illustrating a composition according to the present invention; FIG. 2 is an explanatory diagram illustrating a composition according to the present invention;

[0011] For the sake of mitochondria, it is necessary to intentionally ingest coenzyme Q10 (Coenzyme Q10). Coenzyme Q10 plays a role in transporting proton electrons, which are essential for the production of ATP in the citric acid cycle within mitochondria, to the cytochrome complex. However, no matter how much Coenzyme Q10 you ingest, it will not by itself ensure that your mitochondria function effectively or that aging can be suppressed. While Coenzyme Q10 is essential for mitochondria, it is also necessary to ingest other useful components at the same time.

[0012] However, conventional coenzyme Q10 is fat-soluble and has extremely poor absorption in the body. Therefore, to compensate for the low absorption rate, the amount taken per serving had to be increased. Therefore, it was difficult to produce an orally ingestible composition that combines coenzyme Q10 with other useful ingredients. In contrast, the present invention uses "reduced coenzyme Q10 that has been water-solubilized" (e.g., "ShiroQ" manufactured by PetroEuroAsia Co., Ltd.) as coenzyme Q10, thereby increasing the absorption rate and reducing the required intake. The reduced amount of coenzyme Q10 can then be combined with other useful ingredients to produce an orally ingestible composition.

[0013] The absorption rate of coenzyme Q10 "ShiroQ" is three times that of conventional capsule-type fat-soluble coenzyme Q10 (see Figure 1). Therefore, to ensure the same absorption rate, only one-third of the conventional amount is required, meaning that the two-thirds of the reduced amount of coenzyme Q10 can be used to incorporate other useful ingredients (this is only a calculation, as in reality, the necessary water-solubilizing auxiliary ingredients must be added to process the coenzyme Q10 for water solubility). Furthermore, because "ShiroQ" is a reduced form, it has the advantage of being absorbed into the body while still carrying electrons inside the mitochondria.

[0014] Another useful ingredient is NMN (nicotinamide mononucleotide). Once absorbed into the body, NMN is taken up into cells via the bloodstream and metabolized into NAD+ (nicotinamide adenine dinucleotide), which transports protons (H+) and electrons that serve as fuel for ATP generation in the citric acid cycle within mitochondria. Reduced coenzyme Q10 then transfers the transported protons (H+) and electrons to the ATP generator (cytochrome complex), promoting ATP generation. Furthermore, after completing its role, oxidized coenzyme Q10 receives protons (H+) and is converted back to its reduced form, leading to the next round of power generation. Therefore, the combination of water-soluble reduced coenzyme Q10 and NMN creates a synergistic effect, leading to mitochondrial activation.

[0015] Another useful ingredient is "PQQ." PQQ has the effect of regenerating mitochondria. Similarly, another useful ingredient is "5ALA." 5ALA is a material for the cytochrome complex, which is an ATP generator. ATP is generated by electrons transferred by reduced coenzyme Q10, and this energy is used to create new mitochondria. In this way, by combining "water-soluble reduced coenzyme Q10" with "PQQ" or "5ALA," it is possible to increase the number of mitochondria.

[0016] Another useful ingredient is antioxidants. By incorporating antioxidants such as polyphenols, flavonoids, vitamins C / E, and glutathione, a composition can be obtained that inhibits mitochondrial dysfunction. Reactive oxygen species are generated as by-products during ATP generation through oxygen respiration in mitochondria, and combining multiple antioxidants to match each form can protect mitochondria from reactive oxygen species. Furthermore, even if none of these antioxidants are effective, reduced coenzyme Q10, an antioxidant, acts as a last resort. Antioxidant ingredients used include "water-soluble polyphenol powder" and "water-soluble flavonoid powder" manufactured by PetroEuroAsia Co., Ltd., as well as "water-soluble polyphenols," "flavonoids," "vitamins C / E," and "glutathione" manufactured by other companies.

[0017] The present invention focuses on the function of the electron transport chain of coenzyme Q10, which has been attracting attention as an antioxidant component, and by "simultaneous ingestion" of "water-solubilized reduced coenzyme Q10," "NMN," "5ALA / PQQ," and "antioxidant components," mitochondria are simultaneously activated, increased, and protected, thereby efficiently concentrating "energy production" by mitochondria. In other words, it can be said that simultaneous ingestion of these multiple useful components is extremely important, and by using "water-solubilized reduced" coenzyme Q10 to create extra space, and by blending other useful components into this space, "simultaneous ingestion" is realized.

[0018] This will be explained using Figure 2. Most commercially available coenzyme Q10 is available in soft capsule form. For example, in a 250 mg / tablet product, 50 mg of reduced coenzyme Q10 bulk powder (the main ingredient) is incorporated into a soft capsule containing vegetable oil as the solvent, with the remaining 200 mg being a gelatin membrane encasing the vegetable oil, resulting in a high proportion of non-major ingredients unrelated to the main ingredient (Figure 2, right). In contrast, in the present invention (tablet-formed), if the absorption amount of the soft capsule and coenzyme Q10 is the same, the water-soluble reduced coenzyme Q10 powder is 40 mg (16 mg in terms of reduced coenzyme Q10 bulk powder), leaving the remaining 210 mg as space for incorporating other useful ingredients (major ingredients) (Figure 2, left). This 210 mg free space can be utilized to allow for various formulations of various water-soluble ingredients, enabling the invention to flexibly accommodate the preferences and demands of a wider range of consumers. This is a feature of the present invention.

[0019] The following examples are examples of how to utilize the empty space: In addition to a tablet containing 40 mg of ShiroQ, Example 1 contains 50 mg of NMN, Example 2 contains 20 mg of PQQ and 10 mg of 5ALA, Example 3 contains 50 mg of antioxidant mix, and Example 4 contains 20 mg of NMN, 10 mg of PQQ, 5 mg of 5ALA, and 25 mg of antioxidant mix (all in one).

[0020] As shown in the above examples, the present invention makes it possible to provide tableted supplements that provide the desired effects by adequately and flexibly blending the necessary ingredients to suit each individual's physical condition. Furthermore, for beverages and general foods, it is possible to propose product development that takes advantage of the characteristics of the food, such as all-in-one formulations or single-combination formulations of reduced coenzyme Q10. As shown in the right diagram of Figure 2, soft capsules contain a high proportion of components unrelated to the main ingredients, such as the gelatin membrane that encases vegetable oil, limiting the amount of target ingredients that can be blended. Furthermore, their composition is complex, costing more than twice as much as tableting. Therefore, it must be said that they are unsuitable for manufacturing supplement ingredients that combine multiple ingredients.

[0021] The basic structure of the present invention as explained above is that if mitochondria, whose total weight accounts for approximately 10% of human body weight, are likened to a battery, with 5ALA as the main starting material and the positive side producing ATP, the energy source for cellular activity, reduced coenzyme Q10 transporting electrons on the negative side, and NMN re-reducing oxidized coenzyme Q10 that has released electrons. The composition of the present invention is colorless, tasteless, odorless, and has excellent thermal and pH stability, making it easy to incorporate into any food or beverage, and since only a small amount is required per day, extremely low dosage costs are achieved.

[0022] The composition of the present invention can be widely used to prevent cell deterioration and extend healthy lifespan, particularly to stably increase mitochondrial activity. Specifically, in addition to being ingested as a single component, it can also be incorporated into food and ingested as a processed food product.

Claims

1. A composition comprising reduced coenzyme Q10 (coenzyme Q10) that has been processed to be water-soluble, and NMN (nicotinamide mononucleotide), and characterized by activating mitochondria.

2. A composition comprising reduced coenzyme Q10 (coenzyme Q10) that has been processed to be water-soluble, PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid), and characterized by increasing the amount of mitochondria.

3. A composition characterized by comprising reduced coenzyme Q10 (coenzyme Q10) that has been processed to be water-soluble, and antioxidant ingredients (polyphenols, flavonoids, vitamins C / E, glutathione), and by suppressing the decline in mitochondrial function.

4. A composition comprising reduced coenzyme Q10 (coenzyme Q10) that has been processed to be water-soluble, NMN (nicotinamide mononucleotide), PQQ (pyrroloquinoline quinone) and / or 5ALA (5-aminolevulinic acid), and antioxidant ingredients (polyphenols, flavonoids, vitamins C / E, glutathione), characterized by its ability to increase mitochondrial activity and quantity and inhibit functional decline.

5. A processed food product comprising the composition according to any one of claims 1 to 4.

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