Microneedle patch

Abstract

The present invention comprises: a substrate part; and an insertion part which is formed by processing a portion of the area of the substrate part, and protrudes from the substrate part and is inserted into the skin, wherein the insertion part is itself the processed portion of the area of the substrate part, and an opening having a shape corresponding to the shape of the insertion part is formed in the substrate part.

Description

Microneedle patches

[0001] The present invention relates to a microneedle patch having a reversible needle, and more particularly, to a microneedle patch having a reversible needle that is easy to manufacture while reducing material waste and is configured to be inserted into a user's subcutaneous skin to a set depth so as to increase the drug delivery effect and skin stimulation effect.

[0002] A drug delivery system (DDS) refers to a series of technologies that deliver pharmacologically active substances to cells, tissues, organs, and systems using various physicochemical techniques.

[0003] The most common drug delivery system is oral administration, where medication is taken orally. Other methods include transdermal delivery, which delivers medication to specific parts of the body. Among these, syringe-based drug delivery, which involves puncturing the patient's skin with a metal needle to deliver liquid medication, has been widely used for a long time.

[0004] However, the drug delivery method using a syringe causes pain to the patient when injecting the drug, and also has the disadvantage of causing infection to the patient due to the inconvenience of repeated injections and reuse of the injection needle due to negligence in syringe management.

[0005] Additionally, the above method has the disadvantage that patients cannot administer the drug using a syringe themselves because it requires an inoculator who has knowledge of using a syringe.

[0006] Therefore, in recent years, micro-sized transdermal microneedles, which are much smaller than pen-type syringes, have been manufactured and utilized to improve the drug delivery method using syringes.

[0007] Microneedles are a system that physically delivers drugs by making small holes in the stratum corneum. In 1998, the Prausnitz Group at the Georgia Institute of Technology in the United States proposed the possibility of drug delivery by creating a microneedle array with silicon devices using semiconductor processing technology. Since then, many studies have been actively conducted, and they are being made in various sizes and shapes based on various materials such as silicon, metals, polymers, glass, and ceramics as well as silicon.

[0008] Furthermore, microneedles are used for the delivery of active substances such as drugs and vaccines in vivo, the detection of analytes in the body, and biopsies. They are also used to inject skin care products or drugs into skin tissue, or to extract bodily fluids such as blood from within the skin. Therefore, microneedles are one of the drug delivery methods that has recently seen a surge in use across various fields, as they enable localized yet continuous drug injection and minimize pain upon insertion into the skin.

[0009] Korean Patent No. 10-1947624 discloses a multi-type microneedle formed on a substrate and inserted subcutaneously.

[0010] As shown in FIGS. 1 and 2, the micro needle (10) disclosed in Patent Registration No. 10-1947624 forms a plurality of insertion members (2) by processing a portion (1a) of the area of ​​the substrate portion (1).

[0011] In addition, the plurality of insertion members (2) formed on the substrate (1) can be folded on the substrate (1) and erected vertically, as shown in Fig. 2, in order to be inserted into the user's skin.

[0012] The conventional micro needle (10) having the above configuration has a problem in that material is wasted because a portion (1a) of the surface area of ​​the substrate portion (1) is discarded in the process of forming a plurality of insertion members (2).

[0013] For example, a portion (1a) of the substrate portion (1) is processed by a cutting method using a laser to form the plurality of insert members (2). In this process, a portion (1a) of the substrate portion (1) cut by the laser is discarded, which causes a problem of waste of material.

[0014] In addition, when the laser is set to high power to cut a portion (1a) of the substrate portion (1), there is a problem in that a portion (1a) of the substrate portion (10) is melted by the high temperature of the laser and instead sticks to the plurality of insert members (2).

[0015] Accordingly, there is a problem that a part (1a) of the area of ​​the substrate portion (1a) is not completely separated from the substrate portion (1) and exists, so that the worker must manually remove a part (1a) of the area of ​​the substrate portion (10) cut by the laser as a post-processing. In order to solve this problem, if the laser is set to low power to cut a part (1a) of the area of ​​the substrate portion (1), there is another problem that the mass production speed of the micro needle (10) decreases.

[0016] Meanwhile, in order to erect a plurality of insert members (2) illustrated in FIG. 1 in the state illustrated in FIG. 2, a plurality of insert members (2) laid horizontally must be pressed with a separate mold, but there is a problem that the insert members (2) are easily deformed during this process.

[0017] In addition, there is a problem that the multiple insertion members (2) erected vertically are easily deformed during the process of being inserted into the user's skin, so that not only are the effective drugs not properly delivered, but also the skin stimulation effect is not provided.

[0018] In addition, since the degree to which the insertion member (2) is inserted into the skin is different, the drug delivery efficiency is reduced, and there is a problem of the insertion member (2) being detached from the skin.

[0019] Accordingly, the applicant developed the present invention to solve the above-mentioned problems, and a related prior art document is 'multi-type micro needle' of Korean Patent No. 10-1947624.

[0020] The present invention is intended to solve the above problems, and provides a microneedle patch configured to reduce waste of materials and shorten processing time by processing a portion of the surface area of ​​a substrate to form a plurality of needles, thereby making a portion of the processed surface area into needles that are inserted into the skin.

[0021] The present invention comprises a substrate portion; an insertion portion formed by processing a portion of the surface area of ​​the substrate portion and protruding from the substrate portion and inserted into the skin; wherein the insertion portion is a portion of the surface area of ​​the processed substrate portion itself, and when the insertion portion is bent and protruded from the substrate portion, an opening having a shape corresponding or non-contrasting with the shape of the insertion portion may be formed in the substrate portion.

[0022] In addition, the insertion portion is formed as a pair by processing a portion of the surface area of ​​the substrate portion, and the pair of insertion portions can be placed facing each other with an inverted shape.

[0023] In addition, when the pair of inserts are folded toward the opening formed in the substrate, they can have a form in which they are interlocked with each other by sharing the processing line of the substrate.

[0024] In addition, the insertion portion may include a needle inserted into the skin; and a shoulder member integrally connected to the needle and in contact with the surface of the skin when the needle is inserted into the skin.

[0025] Additionally, the shoulder member may be formed into a convex semicircular shape.

[0026] Additionally, a groove is formed between the needle and the shoulder member, and the groove may be formed in a concave semicircular shape.

[0027] In addition, the protrusion length (d1) of the needle protruding from the substrate is characterized by being greater than the protrusion length (d2) of the shoulder member protruding from the substrate.

[0028] In addition, the maximum length of the needle inserted into the skin is characterized by being a value obtained by subtracting the protrusion length (d1) of the shoulder member from the protrusion length (d1) of the needle.

[0029] Additionally, the needles and shoulder members may be formed in multiple pieces with alternating arrangements.

[0030] In addition, the insertion portion includes a first diagonal edge formed to extend in a diagonal direction from one surface of the substrate portion; a first circular arc edge formed to extend in a convex arc shape from an end of the first diagonal edge; a second circular arc edge formed to extend in a concave arc shape from an end of the first circular arc edge; a second diagonal edge formed to extend in the same diagonal direction as the diagonal direction of the first diagonal edge from an end of the second circular arc edge; a horizontal edge formed to extend in a horizontal direction from an end of the second diagonal edge; and a vertical edge formed to extend in a vertical direction from an end of the horizontal edge; and the needle may include the second diagonal edge, the horizontal edge, and the vertical edge, and the shoulder member may include the first diagonal edge and the first arc.

[0031] Additionally, the insert may include a plurality of shoulder members that come into contact with the surface of the skin.

[0032] According to one embodiment of the present invention, a microneedle patch can minimize the portion of the substrate portion that is discarded during a laser processing process or a pressurizing process of a press equipped with a blade member in the process of forming an insertion portion by processing a portion of the substrate portion, thereby reducing waste of materials and lowering the manufacturing cost. In addition, it can improve the speed of mass production of products by enabling the easy and simple formation of multiple insertion portions through a single processing process.

[0033] In addition, the microneedle patch according to one embodiment of the present invention can relatively increase the number of needles per unit area of ​​the substrate portion compared to the number of needles formed in a conventional microneedle patch, thereby increasing the effective drug delivery effect due to the increase in needle density, and also, when an ion battery is applied, the current delivery effect delivered to the skin can also be increased due to the increase in the area of ​​the substrate portion made of a bioabsorbable metal.

[0034] In addition, a microneedle patch according to one embodiment of the present invention prevents the needle from being bent or deformed during the process of being inserted into the skin, and further prevents the needle inserted into the skin from being detached from the skin, thereby maintaining the skin stimulation effect and effective drug delivery effect by the needle.

[0035] In addition, the microneedle patch according to one embodiment of the present invention maintains the skin area into which the needle is inserted in a taut state by stimulating the skin surface with the shoulder member of the insertion portion, thereby preventing the needle from being bent and deformed during the process of being inserted into the skin, and also preventing the needle inserted into the skin from being detached from the skin, thereby maintaining the skin stimulation effect and effective drug delivery effect by the needle.

[0036] In addition, the microneedle patch according to one embodiment of the present invention sets the insertion length of the needle inserted into the skin by the shoulder member of the insertion portion, so that quality inspection related to the insertion length of the needle can be accurately and easily performed even during the process of processing the substrate portion.

[0037] Figure 1 is a plan view showing the configuration of a conventional microneedle patch.

[0038] Figure 2 is a perspective view showing the insertion member of a conventional microneedle patch in an erected state.

[0039] Figure 3 is a perspective view of a microneedle patch according to one embodiment of the present invention.

[0040] Fig. 4 is a plan view showing the microneedle patch illustrated in Fig. 3 folded parallel to the substrate portion.

[0041] FIG. 5 is a drawing showing a state in which a plurality of insertions are formed in a substrate according to one embodiment of the present invention.

[0042] Figure 6 is a cross-sectional view showing a state in which a needle of an insertion part according to one embodiment of the present invention is inserted into the skin.

[0043] Figure 7 is a plan view showing a needle with a guide groove formed according to one embodiment of the present invention.

[0044] Figure 8 is a plan view showing a needle with a guide hole formed according to one embodiment of the present invention.

[0045] Figure 9 is a plan view showing the configuration of an insertion portion according to another embodiment of the present invention.

[0046] The advantages and features of the present invention and the methods for achieving them will become clear with reference to the embodiments described in detail below together with the accompanying drawings.

[0047] However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, and these embodiments are provided only to ensure that the disclosure of the present invention is complete and to fully inform a person having ordinary skill in the art to which the present invention pertains of the scope of the invention, and the present invention is defined only by the scope of the claims.

[0048] Hereinafter, a microneedle patch according to an embodiment of the present invention will be described in detail with reference to FIGS. 3 to 9. In describing the present invention, specific descriptions of related known functions or configurations are omitted to avoid obscuring the gist of the invention.

[0049] FIG. 3 is a perspective view of a microneedle patch according to one embodiment of the present invention, FIG. 4 is a plan view showing a state in which the microneedle patch illustrated in FIG. 3 is folded parallel to a substrate portion, FIG. 5 is a drawing showing a state in which a plurality of insertion portions are formed in a substrate portion according to one embodiment of the present invention, FIG. 6 is a cross-sectional view showing a state in which a needle of an insertion portion is inserted into skin according to one embodiment of the present invention, FIG. 7 is a plan view showing a state in which a guide groove is formed in a needle according to one embodiment of the present invention, FIG. 8 is a plan view showing a state in which a guide hole is formed in a needle according to one embodiment of the present invention, and FIG. 9 is a plan view showing a configuration of an insertion portion according to another embodiment of the present invention.

[0050] As illustrated in FIGS. 3 to 5, a microneedle patch (100) according to one embodiment of the present invention may include a substrate portion (110); an insertion portion (120, 120') formed by processing a portion of the surface area of ​​the substrate portion (110) and protruding from the substrate portion (110) and inserted into the skin.

[0051] First, the substrate portion (110) can be said to be a component attached to the user's skin, and can have the form of a thin plate having a predetermined area and thickness.

[0052] The substrate (110) can be manufactured in various sizes and shapes to correspond to the skin area to which it is to be attached. For example, the peripheral surface can be manufactured to form a curvature so as to be in close contact with a curved skin area.

[0053] In addition, the substrate portion (110) and the insert portion (120, 120') to be described later can be made of a metal containing at least one component among magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals.

[0054] For reference, there are cases where bioabsorbable metals have been commercialized domestically and internationally as magnesium-based alloys for use in orthopedic implants, and bioabsorbable metals applied to orthopedic implants are focused on minimizing the rate of decomposition in the body or improving corrosion resistance to ensure safe fracture fixation.

[0055] However, unlike bioabsorbable metals used in orthopedics, bioabsorbable metals forming microneedles (200) according to one embodiment of the present invention can be applied with a mechanism that accelerates the decomposition rate in the body and enables the supply of minerals together with drug release under the skin.

[0056] For example, magnesium, calcium, and zinc, which are used as bioabsorbable metals, can have a mechanism to react with water in the body and decompose, releasing hydrogen gas.

[0057] The substrate portion (110) and insert portion (120, 120') formed of the bioabsorbable metal as described above release ions and decomposition products under the skin, and the hydrogen gas generated as a byproduct provides a swelling effect under the skin, which can also induce a wrinkle improvement effect.

[0058] In addition, ZnO and MgCl, which are byproducts generated when magnesium and zinc, which are components of bioabsorbable metals, are inserted into the body, can also serve as drug delivery enhancers that improve the subcutaneous absorption of the active ingredient or drug loaded in the substrate (110) and the insertion portion (120) described below while remaining subcutaneously. Therefore, the substrate (110) and the insertion portion (120, 120') described below, which are formed of bioabsorbable metals, can effectively deliver the drug loaded therein subcutaneously.

[0059]

[0060] The above insertion portion (120, 120') can be said to be a component formed by processing a portion of the surface area of ​​the substrate portion (110), as shown in FIGS. 3 to 5.

[0061] The insertion portion (120, 120') can be formed in the substrate portion (110) by a cutting process using a laser or a pressing process using a press equipped with a blade member.

[0062] For example, when a laser output from a laser processing device is moved along the solid line (processing line) illustrated in FIG. 4, an insertion portion (120, 120') according to one embodiment of the present invention can be formed in the substrate portion (120). Accordingly, the insertion portion (120, 120') can be said to be a portion of the surface area of ​​the processed substrate portion (110).

[0063] In addition, the insertion portion (120, 120') can be formed in multiple pieces by processing a portion of the surface of the substrate portion (110) along a processing line through a processing process using a laser or blade member.

[0064] In detail, the insertion portion (120, 120') can be said to be a component formed when a laser output from a laser device moves along the processing line of the substrate portion (120), and similarly, it can be said to be a component formed when a press device using a blade member presses the processing line of the substrate portion (120).

[0065] For reference, in one embodiment of the present invention, it is described that when a portion of the surface area of ​​the substrate portion (110) is processed along a processing line, a pair of insert portions (120, 120') are formed, and in the drawing, a pair of insert portions (120, 120') are illustrated as being formed on one opening (111).

[0066] A pair of insert parts (120, 120') can be folded in a state parallel to the substrate part (110) and then bent in the direction of arrows A and B shown in Fig. 4 to be erected on the substrate part (110). For reference, a pair of insert parts (120, 120') shown in Fig. 4 can be erected by applying pressure to a mold having a shape corresponding to the processing area of ​​the substrate part (110).

[0067] As illustrated in FIG. 2, when a pair of inserts (120, 120') are erected on the substrate (110), an opening (111) can be formed in the substrate (110).

[0068] The above opening (111) can serve as a passage through which a drug can be injected.

[0069] In addition, an adhesive member (not shown) is provided on one side of the substrate (110) (the side not facing the skin), and a portion of the adhesive member (not shown) corresponding to the opening (110) can come into contact with the user's skin through the opening (110).

[0070] In addition, since the opening (111) is a space where the pair of inserts (120, 120') were placed before being erected, it may have a shape and area corresponding to the inserts (120, 120') of the above-mentioned one. For reference, when the pair of inserts (120, 120') are folded toward the opening (111) as illustrated in Fig. 4, the opening (111) may be blocked. At this time, the pair of inserts (120, 120') have a shape in which they are interlocked with each other.

[0071] As above, in order for the opening (111) to have the same area and shape as the area and shape formed by the pair of inserts (120, 120') cooperating with each other, the inserts (120, 120') on the one side must be placed facing each other with an inverted shape, as shown in FIGS. 3 and 4.

[0072] When a pair of insertion portions (120, 120') are formed on the substrate portion (110) in an inverted shape, even if a portion of the substrate portion (110) is processed, the amount of the substrate portion (110) discarded during the processing can be minimized. In addition, since a pair of insertion portions (120, 120') can be formed on the substrate portion (110) only by linearly moving a laser output from a laser processing device, the mass production time of microneedles can be significantly reduced compared to the prior art.

[0073] For reference, in one embodiment of the present invention, the opening (111) is described and illustrated in the drawings as having the same area and shape as the area and shape formed by the pair of inserts (120, 120') cooperating with each other, but is not limited thereto. For example, the opening (111) may have an area and shape different from the area and shape formed by the pair of inserts (120, 120') cooperating with each other.

[0074] For example, so that the pair of insert parts (120, 120') can be easily bent and protruded on the substrate part (110), a hole that helps the bending of the insert parts (120, 120') may be further formed in a portion of the area of ​​the substrate part (110) where the insert parts (120, 120') are formed, so that the area and shape of the opening (111) may be set to be different from the area and shape in which the insert parts (120, 120') cooperate with each other.

[0075] The above insertion part (120, 120') may include a needle (121, 121') inserted into the skin, as shown in FIGS. 2 and 6, and a shoulder member (122, 122') integrally connected to the needle (121, 121') and in contact with the surface of the skin when the needle (121, 121') is inserted into the skin.

[0076] The above needle (121, 121') is a component inserted into the user's skin and may have a shape that protrudes vertically from the substrate (110).

[0077] The needle (121, 121') may have a shape in which the width gradually narrows as it moves away from the substrate (110). That is, the width may gradually narrow from the bottom connected to the substrate (110) to the top. Accordingly, the upper end of the needle (121, 121') takes on a sharp shape that is easy to insert into the skin.

[0078] Additionally, the needle (121, 121') may have the highest protrusion length (d1) on the substrate (110) when the insertion portion (120, 120') is erected on the substrate (110).

[0079] The shoulder member (122, 122') is formed integrally with the needle (12l, 121') as illustrated in FIGS. 3, 4, and 6, and may have a shape similar to a human shoulder. That is, the shoulder member (122, 122') may be formed in a convex semicircular shape.

[0080] The shoulder member (122, 122') can protrude from the substrate (110) with a protrusion length (d2) that is smaller than the protrusion length (d1) of the needle (121, 121') protruding from the substrate (110).

[0081] The above shoulder member (122, 122') can be said to be a component that serves as a stopper to limit the insertion length of the needle (121, 121') inserted into the skin, and also prevents bending or deformation that occurs during the process of inserting the needle (121, 121') into the skin.

[0082] Additionally, the shoulder member (122, 122') can also prevent the needle (121, 121') already inserted into the skin from being pulled out of the skin.

[0083] Since the shoulder member (122, 122') has the second highest protrusion length (d2) on the substrate (110), it enables the needle (121, 121') to be inserted into the skin by a set length. In other words, the insertion length of the needle (121, 121') inserted into the skin can be determined by subtracting the protrusion length (d2) of the shoulder member (122, 122') from the protrusion length (d1) of the needle (121, 121').

[0084] In other words, the maximum length at which the needle (121, 121') is inserted into the skin can be said to be the value obtained by subtracting the protruding length (d2) of the shoulder member (122, 122') from the protruding length (d1) of the needle (121, 121').

[0085] Accordingly, when the substrate (110) is brought into close contact with the user's skin, the needles (121, 121') can be preferentially inserted into the skin, as illustrated in FIG. 6. When the needles (121, 121') are inserted into the skin to a certain extent, the insertion length of the needles (121, 121') can be limited because the shoulder members (122, 122') contact and press the surface of the skin.

[0086] In addition, since the insertion length of the needle (121, 121') inserted into the skin can be determined even during the process of forming the insertion portion (120, 120') in the substrate portion (110), the quality inspection of the needle (121, 121') can be accurately performed without banding the insertion portion (120, 120').

[0087] The needles (121, 121') and shoulder members (122, 122') configured as described above can be formed in multiple pieces while being arranged alternately.

[0088] Accordingly, by having multiple shoulder members (122, 122') contact and pressurize the surface of the skin, the surface of the skin into which the needles (121, 121') are inserted can be maintained in an expanded state.

[0089] In detail, as illustrated in FIG. 6, since the multiple shoulder members (122) press against the surface of the skin, the surface area of ​​the skin positioned between the multiple shoulder members (122) maintains a taut state of tension. Accordingly, the needle (121) positioned between the multiple shoulder members (122) can be easily inserted into the skin, and furthermore, the needle (121) can be prevented from being detached from the skin to the outside.

[0090] Accordingly, the shoulder member (122, 122') of the insertion portion (120, 120') functions as a stopper to limit the insertion length of the needle (121, 121') inserted into the skin, as described above, and furthermore, it prevents the needle (121, 121') from being bent or deformed during the process of being inserted into the skin, and also prevents the needle (121, 121') already inserted into the skin from being detached from the skin.

[0091] Additionally, the insertion portion (120, 120') may further include a groove (123, 123') formed between the needle (121, 121') and the shoulder member (122, 122').

[0092] The above groove (123, 123') can be formed in a concave semicircular shape.

[0093] The above grooves (123, 123') may be considered as components that do not come into contact with the surface of the skin, as illustrated in Fig. 6. The grooves (123, 123') may serve as passages through which the drug may flow, so that the drug injected through the opening (111) of the aforementioned substrate portion (110) may be evenly spread into the skin.

[0094] For example, when a drug is injected through the opening (111), the drug does not only remain on the surface of the skin exposed through the opening (111), but can flow to the entire surface of the skin in close contact with the substrate (110) through the groove (123, 123').

[0095] In addition, the insertion portion (120), as illustrated in FIG. 3, may include a first diagonal edge (122a) extending in a diagonal direction from one surface of the substrate portion (110); a first circular edge (122b) extending in a convex arc shape from an end of the first diagonal edge (122a); a second circular edge (123a) extending in a concave arc shape from an end of the first circular edge (122b); a second diagonal edge (121a) extending in the same diagonal direction as the first diagonal edge (122a) from an end of the second circular edge (123a); a horizontal edge (121b) extending in a horizontal direction from an end of the second diagonal edge (121a); ​​and a vertical edge (121c) extending in a vertical direction from an end of the horizontal edge (121b).

[0096] The needle (121, 121') may be configured to include the second diagonal side (121a), the horizontal side, and the vertical side, the shoulder member (122, 122') may be configured to include the first diagonal side (122a) and the first circular side (123a), and the groove (123, 123') may be configured to include the second circular side (123a).

[0097] According to one embodiment of the present invention, the microneedle patch (100) configured as described above can minimize the portion of the substrate (110) that is discarded in the laser processing process or the pressing process of a press equipped with a blade member during the process of forming the insertion portion (120) by processing a portion of the surface of the substrate (110), thereby reducing the waste of materials and lowering the manufacturing cost. In addition, it is possible to easily and simply form a plurality of insertion portions (120) through a single processing process, thereby improving the speed of mass production of the product.

[0098] In addition, the microneedle patch (100) according to one embodiment of the present invention can relatively increase the number of needles (121, 121') per unit area of ​​the substrate portion (110) compared to the number of needles formed in a conventional microneedle patch, thereby increasing the drug delivery effect due to the increase in the density of the needles (121, 121'), and also, when an ion battery is applied, the current delivery effect transmitted to the skin can also be increased due to the increase in the area of ​​the substrate portion (110) made of a bioabsorbable metal.

[0099] Although specific embodiments of the present invention have been described so far, it is obvious that various modifications are possible within the scope of the present invention.

[0100] For example, as shown in FIGS. 7 and 8, a guide groove (124) or a guide hole (125) that helps the transfer of a drug or microcurrent may be formed in the needle (121, 121').

[0101] The guide groove (124) illustrated in Fig. 7 can be formed along the longitudinal direction of the needle (121, 121') on one side or the other side of the needle (121, 121').

[0102] Likewise, the guide hole (125) illustrated in FIG. 8 is formed along the longitudinal direction of the needle (121, 121') so as to separate the needle (121, 121') into two.

[0103] The above guide groove (124) and guide hole (125) can be said to be components that increase the transmission rate of effective ingredients or microcurrents delivered into the skin through needles (121, 121').

[0104] Therefore, it is preferable that a guide groove (124) or a guide hole (125) that separates the needle (121, 121') into two is formed in the needle (121, 121') according to one embodiment of the present invention.

[0105] For reference, the microneedle patch (100) according to one embodiment of the present invention is not limited to the function of delivering an effective ingredient into the skin in addition to the skin stimulation effect, and can also be applied to an iontophoresis treatment device to deliver microcurrent, and can also be applied to various frequency treatment devices to deliver high or low frequencies.

[0106] In addition, as illustrated in FIG. 9, the insertion portion (120, 120') formed by processing a portion of the substrate portion (110) is composed only of a plurality of shoulder members (121, 121') that come into contact with the surface of the skin, and can be used for the purpose of stimulating and expanding the surface of the skin. For example, when applied as an acne patch that stimulates the skin to alleviate acne, the insertion portion (120, 120') can be composed only of a plurality of shoulder members (121, 121').

[0107] Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined not only by the scope of the claims described below, but also by equivalents of the claims.

[0108] The present invention can be applied and sold in the medical and skin beauty fields.

Claims

1. Substrate; It includes an insertion portion formed by processing a portion of the surface area of ​​the above substrate portion and protruding from the above substrate portion and inserted into the skin; The above insertion portion is a portion of the surface area of ​​the processed substrate portion itself, A microneedle patch characterized in that, when the insertion part is protruded by being banded from the substrate part, an opening having a shape corresponding or non-conforming to the shape of the insertion part is formed in the substrate part.

2. In paragraph 1, The above insertion portion is formed as a pair by processing a portion of the surface area of ​​the substrate portion, A microneedle patch characterized in that the pair of inserts are positioned facing each other with an inverted shape.

3. In paragraph 2, A microneedle patch characterized in that the pair of inserts are folded toward the opening formed in the substrate and have an interlocking shape by sharing the processing line of the substrate.

4. In paragraph 1, The above insertion part, A needle inserted into the skin; and A microneedle patch characterized by comprising a shoulder member integrally connected to the needle and in contact with the surface of the skin when the needle is inserted into the skin.

5. In paragraph 4, A micro needle patch characterized in that the shoulder member is formed in a convex semicircular shape.

6. In paragraph 4, A micro needle patch characterized in that a groove is formed between the needle and the shoulder member, and the groove is formed in a concave semicircular shape.

7. In paragraph 4, A microneedle patch characterized in that the protrusion length (d1) of the needle protruding from the substrate is greater than the protrusion length (d2) of the shoulder member protruding from the substrate.

8. In paragraph 7, A microneedle patch characterized in that the maximum length of the needle inserted into the skin is a value obtained by subtracting the protrusion length (d1) of the shoulder member from the protrusion length (d1) of the needle.

9. In paragraph 4, A micro needle patch characterized in that the needles and shoulder members are formed in a plurality of alternately arranged pieces.

10. In paragraph 4, The above insertion part, A first diagonal edge formed to extend diagonally from one side of the above substrate portion; A first circular arc extending in the shape of a convex arc from the end of the first diagonal line; A second circular arc formed in the shape of a concave arc extending from the end of the first circular arc; A second diagonal edge formed by extending in the same diagonal direction as the diagonal direction of the first diagonal edge from the end of the second circular arc; A horizontal side formed by extending horizontally from the end of the second diagonal side; and A vertical side formed to extend vertically from the end of the horizontal side; The above needle includes the second diagonal side, the horizontal side, and the vertical side, A microneedle patch characterized in that the shoulder member includes the first diagonal side and the first circular side.

11. In paragraph 1, The above insertion part, A microneedle patch comprising a plurality of shoulder members in contact with the surface of the skin.

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