Fluid-filled intraocular lens and related methods

Abstract

An intraocular lens to replace a natural lens of an eye. The intraocular lens can include a bladder and a self-sealing valve. With the intraocular lens positioned in a capsular bag of the eye, the bladder can be filled with a fluid and / or gas through the self-sealing valve. Fluid and / or gas can be added or removed to achieve a desired refractive power. The bladder can be pre-shaped prior to implantation.

Description

DORAI.004WO PATENTFLUID-FILLED INTRAOCULAR LENS AND RELATED METHODSCROSS REFERENCE

[0001] This application claims the priority benefit of U.S. Provisional Application No. 63 / 685,048, filed August 20, 2024, which is hereby incorporated by reference in its entirety. All applications for which a foreign or domestic priority is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference under 37 CFR 1.57.FIELD

[0002] This disclosure relates to intraocular lenses, and more specifically, fluid- filled intraocular lens and methods of implantation.BACKGROUND

[0003] As the eye ages, the natural lens may cloud and negatively impact vision. Cataract surgery can be performed to remove the clouded natural lens from the capsular bag and implant an artificial intraocular lens (IOL) to improve vision.SUMMARY

[0004] Current IOLS include numerous challenges. Current IOLS are bulky and necessitate large incisions at an anterior of a capsular bag, such as a complex capsulorhexis, to position the IOL within the capsular bag. These large incisions can increase surgical risk, such as compromising the capsular bag (e.g., tears), and / or prolong recovery time. Conventional IOLs typically have a fixed refractive power, requiring precise preoperative measurements and calculations for acceptable outcomes, and postoperative refractive errors often necessitate additional corrective procedures. Advanced IOLs that include multifocality or extended depth of focus are limited by their complexity and potential disturbances, such as glare and / or halos. The IOLs disclosed herein can address one or more of the foregoing challenges.

[0005] The IOLs described herein can simplify surgical procedures, enhance patient outcomes, and / or provide additional functionalities such as multifocal vision, extended depth of focus, controlled therapeutic release (e.g., address inflammation and / or infection),and / or adjustability by way of fluid management with one or more self-sealing valves. The lOLs described herein can include a bladder (e.g., balloon, bag) that can be implanted in an unfilled (e.g., deflated, collapsed) state through a small incision into the capsular bag, which can avoid a large incision at the anterior of the capsular bag. The small incision can be off the optical axis of the eye. With the IOL positioned in the capsular bag, the bladder can be filled (e.g., inflated, expanded) with matter, such as liquid (e.g., clear liquid) and / or gas. The bladder can be filled with different quantities of matter to precisely adjust refractive power, which can at least include accommodating a wide range of refractive corrections (e.g., 0 to 35 diopters). The IOL, when filled, can fill the capsular bag, which can mimic the size and / or shape of the natural lens that the IOL is replacing and / or reduce the risk of post-operative capsular bag shrinkage. In some variants, the refractive correction can be adjusted in small increments (e.g., 0.05 diopters) and / or along a continuum. The bladder can include a self-sealing valve (e.g., duckbill valve) through which the matter can be introduced and / or removed. A tube, such as a needle, can be inserted through the self-sealing valve to introduce or remove matter from an interior of the bladder with the IOL positioned in the capsular bag. The self-sealing valve can prevent the matter from leaking out of the bladder. The bladder can be compliant (e.g., highly compliant) to be responsive to ocular forces to provide accommodative power. The bladder can be pre-shaped, which can encourage correct alignment and / or stability within the capsular bag to impede dislocation and / or rotation of the IOL. The IOL can include features (e.g., surface features, such as patterns) to amplify accommodative power changes provided by the IOL. The IOL can include advanced optical features to enhance visual outcomes, such as multifocality, extended depth of focus, and / or diffractive optics. The lens can include features to release one or more therapeutics (e.g., hormones, nutrients, medicaments, drugs, vitamins, chemicals, etc.), which can be controllably released. For example, the lens can include one or more reservoirs for releasing (e.g., controllably releasing) one or more therapeutics. The overall diameter of the bladder can at least vary from 10-15 millimeters to fit different eye anatomies. The lens can include an optic diameter (e.g., clear optic diameter) that can at least vary from 4-15 millimeters, which can provide appropriate light transmission and / or a wide field of vision.

[0006] In some variants, the techniques described herein relate to an intraocular lens including: a bladder configured to hold fluid, the bladder including a peripheral wall withone or more features to amplify a dioptric power provided by the intraocular lens; and a selfsealing valve through which fluid is configured to be introduced into the bladder to inflate the bladder with the intraocular lens positioned in a capsular bag of an eye; wherein the bladder, when holding the fluid, is configured to be compliant such that the bladder reshapes in response to ocular forces.

[0007] In some variants, the techniques described herein relate to an intraocular lens, wherein the self-sealing valve is a duckbill valve.

[0008] In some variants, the techniques described herein relate to an intraocular lens, wherein the self-sealing valve is configured to form a seal around a needle inserted through the self-sealing valve to add or remove fluid.

[0009] In some variants, the techniques described herein relate to an intraocular lens, wherein the bladder is pre-shaped.

[0010] In some variants, the techniques described herein relate to an intraocular lens, wherein the peripheral wall of the bladder includes a uniform thickness.

[0011] In some variants, the techniques described herein relate to an intraocular lens, wherein the peripheral wall is disposed at an anterior-facing portion and a posterior-facing portion of the bladder.

[0012] In some variants, the techniques described herein relate to an intraocular lens, wherein the peripheral wall extends circumferentially about an optical axis of the intraocular lens.

[0013] In some variants, the techniques described herein relate to an intraocular lens, wherein the bladder is configured to be rolled up without fluid introduced into the bladder.

[0014] In some variants, the techniques described herein relate to an intraocular lens, wherein the bladder is configured to be folded up without fluid introduced into the bladder.

[0015] In some variants, the techniques described herein relate to an intraocular lens, wherein the self-sealing valve includes two or more surfaces that are biased toward each other to form a seal.

[0016] In some variants, the techniques described herein relate to an intraocular lens, wherein the self-sealing valve includes a tube and a sealing portion, the tube extending from outside the bladder to within an inner reservoir of the bladder.

[0017] In some variants, the techniques described herein relate to an intraocular lens, wherein the sealing portion includes two sheets biased toward each other to provide a seal.

[0018] In some variants, the techniques described herein relate to an intraocular lens, wherein lateral edges of the two sheets are bonded together.

[0019] In some variants, the techniques described herein relate to an intraocular lens, wherein the sealing portion is disposed inside the inner reservoir.

[0020] In some variants, the techniques described herein relate to the intraocular lens of any of the proceeding claims, wherein the bladder is configured to hold different quantities of fluid to provide different refractive powers.

[0021] In some variants, the techniques described herein relate to the intraocular lens of any of the proceeding claims, wherein the bladder includes silicone.

[0022] In some variants, the techniques described herein relate to an intraocular lens 1-1, wherein the fluid is saline.

[0023] In some variants, the techniques described herein relate to the intraocular lens of any of the proceeding claims, wherein the intraocular lens includes one or more reservoirs of a therapeutic.

[0024] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more reservoirs are configured to release the therapeutic in a controlled manner within the eye.

[0025] In some variants, the techniques described herein relate to an intraocular lens, wherein the fluid includes a fluid.

[0026] In some variants, the techniques described herein relate to an intraocular lens, wherein the fluid includes a gas.

[0027] In some variants, the techniques described herein relate to an intraocular lens, wherein the bladder is configured to be flattened when zonules of the eye are tensioned and rounded when the zonules of the eye are relaxed.

[0028] In some variants, the techniques described herein relate to an intraocular lens, wherein the bladder includes a material having a refractive index that is less than 1.5.

[0029] In some variants, the techniques described herein relate to an intraocular lens, wherein the fluid includes a material having a refractive index that is less than 1.5.

[0030] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more features include refractive monofocal optic characteristics.

[0031] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more features include extended depth of focus optic characteristics.

[0032] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more features include refractive multifocal optic characteristics.

[0033] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more features include diffractive multifocal optic characteristics.

[0034] In some variants, the techniques described herein relate to an intraocular lens, wherein the one or more features include toric optic characteristics.

[0035] In some variants, the techniques described herein relate to a method of implanting an intraocular lens within a capsular bag of a patient, the method including: reducing a volume of a bladder of the intraocular lens; placing the intraocular lens into the capsular bag through an opening in the capsular bag; positioning the intraocular lens such that a self-sealing valve of the intraocular lens is accessible; inserting a needle through the selfsealing valve; injecting fluid into an inner reservoir of the bladder through the needle; and removing the needle such that the self-sealing valve closes to impede the fluid from leaking.

[0036] In some variants, the techniques described herein relate to a method, wherein reducing the volume of the bladder includes rolling up the bladder.

[0037] In some variants, the techniques described herein relate to a method, wherein reducing the volume of the bladder includes folding the bladder.

[0038] In some variants, the techniques described herein relate to a method, further including cutting the opening in the capsular bag.

[0039] In some variants, the techniques described herein relate to a method, wherein the opening includes a diameter of 2-3 millimeters.

[0040] In some variants, the techniques described herein relate to a method of forming an intraocular lens, the method including: stacking two sheets on top of each other; bonding lateral edges of the two sheets together to form an assembly; shaping a first end of the assembly to form an opening; coupling a tube to the first end of the assembly; and bonding a first sheet and a second sheet together with the tube disposed therebetween such that the tubeextends out from between the first sheet and the second sheet to within an inner reservoir between the bonded first sheet and the second sheet.

[0041] In some variants, the techniques described herein relate to a method, wherein the first sheet and the second sheet each include a circular shape.

[0042] In some variants, the techniques described herein relate to a method of performing cataract surgery, the method including: removing a natural lens from a capsular bag of an eye through an opening in the capsular bag; flowing a fluid into the capsular bag through the opening; and placing a lens over the opening to impede the fluid from leaking out of the capsular bag.

[0043] In some variants, the techniques described herein relate to a method, wherein placing the lens over the opening includes inserting the lens inside the capsular bag.

[0044] In some variants, the techniques described herein relate to a method, further including coupling the lens to the capsular bag.

[0045] In some variants, the techniques described herein relate to a method, wherein coupling the lens includes adhering the lens to the capsular bag.

[0046] In some variants, the techniques described herein relate to a method, wherein coupling the lens includes securing the lens to the capsular bag with one or more anchors of the lens.

[0047] In some variants, the techniques described herein relate to a method, wherein coupling the lens includes positioning a biased periphery of the lens to interface with the capsular bag.

[0048] In some variants, the techniques described herein relate to a method, further including coupling the lens to anatomy of the eye with one or more anchors.

[0049] In some variants, the techniques described herein relate to a method, wherein the lens is a meniscus lens.

[0050] In some variants, the techniques described herein relate to a method and 39- 44, wherein placing the lens over the opening includes positioning the lens at an exterior of the capsular bag.

[0051] In some variants, the techniques described herein relate to a method of performing cataract surgery, the method including: removing a natural lens from a capsular bag of an eye through an opening in the capsular bag; placing a lens over the opening; insertinga needle through a self-sealing valve of the lens; and injecting fluid into the capsular bag; and removing the needle from the self-sealing valve.

[0052] In some variants, the techniques described herein relate to a method, wherein the fluid is saline.

[0053] In some variants, the techniques described herein relate to a method, wherein the lens is a meniscus lens.

[0054] In some variants, the techniques described herein relate to a method, wherein placing the lens over the opening includes positioning the lens within the capsular bag.

[0055] In some variants, the techniques described herein relate to a method, wherein placing the lens over the opening includes positioning the lens at an exterior of the capsular bag.

[0056] Neither the preceding summary nor the following detailed description purports to limit or define the scope of protection. The scope of protection is defined by the claims.BRIEF DESCRIPTION OF THE DRAWINGS

[0057] The abovementioned and other features of the embodiments disclosed herein are described below with reference to the drawings of the embodiments. The illustrated embodiments are intended to illustrate, but not to limit, the scope of protection. Various features of the different disclosed embodiments can be combined to form further embodiments, which are part of this disclosure.

[0058] FIG. 1A illustrates a clouded natural lens in a capsular bag with a capsulorhexis providing access into the capsular bag.

[0059] FIG. IB illustrates a clouded natural lens in a capsular bag with a small incision providing access into the capsular bag.

[0060] FIG. 2A illustrates a cross-sectional view of an intraocular lens (IOL) with a deflated bladder and a self-sealing valve.

[0061] FIG. 2B illustrates a cross-sectional view of the IOL of FIG. 2A with the self-sealing valve opened and matter (e.g., fluid and / or gas) being introduced through the opened self-sealing valve into the bladder.

[0062] FIG. 2C illustrates a cross-sectional view of the IOL of FIG. 2A with the bladder inflating from the matter being introduced through the opened self-sealing valve into the bladder.

[0063] FIG. 2D illustrates a cross-sectional view of the IOL of FIG. 2A with the bladder inflated with matter and the self-sealing valve closed.

[0064] FIG. 3A illustrates the capsular bag with the natural lens removed and a small incision.

[0065] FIG. 3B illustrates the IOL of FIGS. 2A-2D with the deflated bladder being introduced into the capsular bag through the small incision.

[0066] FIG. 3C illustrates the IOL of FIGS. 2A-2D with the deflated bladder in the capsular bag.

[0067] FIG. 3D illustrates a cross-sectional view of the IOL of FIGS. 2A-2D with the bladder deflated and oriented within the capsular bag for inflation.

[0068] FIG. 3E illustrates a cross-sectional view of the IOL of FIGS. 2A-2D with a tube (e.g., needle, cannula) extending through the self-sealing valve and delivering matter (e.g., liquid and / or gas) into the bladder.

[0069] FIG. 3F illustrates a cross-sectional view of the IOL of FIGS. 2A-2D with the bladder inflating from matter being introduced through the opened self-sealing valve into the bladder.

[0070] FIG. 3G illustrates a cross-sectional view of the IOL of FIGS. 2A-2D with the bladder inflated with matter therein and the self-sealing valve closed.

[0071] FIG. 3H illustrates the IOL of FIGS. 2A-2D with the bladder inflated with matter therein and the self-sealing valve closed.

[0072] FIG. 4A illustrates an IOL with a bladder and a self-sealing valve.

[0073] FIG. 4B illustrates a cross-sectional view of the IOL of FIG. 4A.

[0074] FIG. 5A illustrates a perspective view of a sealing portion of the self-sealing valve of the IOL of FIG. 4A.

[0075] FIG. 5B illustrates a front view of the sealing portion of the self-sealing valve of the IOL of FIG. 4A.

[0076] FIG. 5C illustrates a cross-sectional view of the sealing portion of the selfsealing valve of the IOL of FIG. 4A.

[0077] FIG. 5D illustrates a rearview of the sealing portion of the self-sealing valve of the IOL of FIG. 4A.

[0078] FIG. 6A illustrates a sheet (e.g., leaflet) of material that can be used to form the sealing portion of FIGS. 5A-5D.

[0079] FIG. 6B illustrates two stacked sheets (e.g., leaflets) of material that can be used to form the sealing portion of FIGS. 5A-5D.

[0080] FIG. 6C illustrates the two stacked sheets of material of FIG. 6B coupled together along a first lateral edge.

[0081] FIG. 6D illustrates the two stacked sheets of material of FIG. 6C coupled together along a first lateral edge and a second lateral edge opposite the first to form an assembly.

[0082] FIG. 6E illustrates the assembly of FIG. 6D shaped to be open on a first end and biased closed on a second end opposite the first end.

[0083] FIG. 6F illustrates the shaped assembly of FIG. 6E with a tube disposed at the opening of the first end.

[0084] FIG. 7A illustrates a lens coupled to a capsular bag with the natural lens removed and covering an opening providing access into the capsular bag.

[0085] FIG. 7B illustrates a peripheral portion of the lens of FIG. 7A.

[0086] FIG. 8 illustrates a diffractive optic to provide near, intermediate, and distance focus.

[0087] FIG. 9 illustrates a diffractive optic.

[0088] FIG. 10 illustrates a diffractive optic.

[0089] FIG. 11 illustrates a refractive multifocal optic.

[0090] FIG. 12 illustrates a refractive multifocal optic.

[0091] FIG. 13 illustrates a progress optic.DETAILED DESCRIPTION

[0092] Although certain embodiments and examples are described below, this disclosure extends beyond the specifically disclosed embodiments and / or uses and obvious modifications and equivalents thereof. Thus, it is intended that the scope of this disclosure should not be limited by any particular embodiments described below.

[0093] FIG. 1 A illustrates an eye 100 with a clouded natural lens 108 disposed in a capsular bag 106 of the eye 100. The capsular bag 106 is anterior of a vitreous body 126 and coupled at the periphery to zonules 116 extending inward from a ciliary body 114 posterior of a ciliary sulcus 118. During cataract surgery, a cutting tool 124 (e.g., blade, cutting edge) can be used to cut an opening 122 (e.g., incision) in a cornea 102, which is disposed inward of the sclera 140, to access the capsular bag 106 through the pupil 120. The cutting tool 124 can be used to cut a large opening 110 in an anterior portion of the capsular bag 106, which can be a capsulorhexis, to access an interior of the capsular bag 106. Alternatively, as illustrated in FIG. IB, the cutting tool 124 can be used to cut one or more small openings 112 in an anterior portion of the capsular bag 106, which can be off an optical axis or diameter of the eye 100, to access an interior of the capsular bag 106. In some variants, the clouded natural lens 108 can be removed through the large opening 110 or one or more small openings 112 with phacoemulsification and aspiration. In some variants, the clouded natural lens 108 can be emulsified with heat (e.g., heated fluid and / or element) applied thereto and aspirated through the large opening 110 or one or more small openings 112. With the clouded natural lens 108 removed, an artificial intraocular lens (IOL) can be inserted into the capsular bag 106. Replacing the clouded natural lens 108 with an artificial IOL can improve the vision of the patient.

[0094] FIGS. 2A-2D illustrate an artificial intraocular lens (IOL) 128, which can also be referred to as a lens. The IOL 128 can be inserted into the capsular bag 106, which can include being inserted through the large opening 110 or one or more small openings 112.

[0095] The IOL 128 can include a bladder 130, which can also be referred to as sack, pouch, balloon, and / or bag. The bladder 130 can include an inner reservoir 132. The inner reservoir 132 can receive matter therein, which can include a fluid and / or gas (e.g., air). For example, the inner reservoir 132 can receive a fluid, which can be a clear and / or biocompatible fluid, such as saline, balanced salt solution, or a specialized ophthalmic viscoelastic solution. The bladder 130 can be pre-shaped, which can encourage correct alignment and / or stability of the IOL 128 within the capsular bag 106 to impede dislocation and / or rotation of the IOL 128. Even when pre-shaped, the IOL 128 can be collapsed (e.g., rolled, folded, compressed) into a smaller volume for implantation into the capsular bag 106, which can reduce the size of the large opening 110 and / or one or more small openings 112.The bladder 130 can be designed to be compliant or non-complaint, which can depend on a desired application and / or patient-specific requirements. For a compliant bladder 130, the bladder 130 can include one or more elastic materials that can expand and / or contract with relative ease, which can provide a soft and / or flexible fit within the capsular bag 106. A compliant bladder 130 can be at least benefit patients requiring gentle placement and / or accommodation to the natural movements of the eye 100. For a non-compliant bladder 130, the bladder 130 can include a more rigid material compared to a compliant design. The non- compliant bladder 130 can maintain a fixed shape once inflated (e.g., filled with matter such as fluid and / or gas). The non-compliant bladder 130 can provide stable and / or precise refractive correction when implanted in the capsular bag 106. The non-compliant bladder 130 can at least benefit patients requiring more consistent and / or durable optical properties. The bladder 130 can include a peripheral wall, which can include a uniform thickness. The peripheral wall of the bladder 130 can be flexible. The bladder 130 can, in some variants, be rolled up without matter (e.g., without a substantial amount of matter) disposed therein, which can facilitate implantation through a small opening in the capsular bag 106. The bladder 130 can, in some variants, be folded up without matter (e.g., without a substantial amount of matter) disposed therein, which can include being folded once, twice, three, four, or more times, which can facilitate implantation through a small opening in the capsular bag 106. The peripheral wall can extend from an anterior portion to a posterior portion of the bladder. The peripheral wall can extend from an anterior-facing portion to a posterior-facing portion of the bladder. The peripheral wall can extend circumferentially about an optical axis of the IOL 128. The peripheral wall can collapse when not filled with matter (e.g., fluid and / or gas).

[0096] The IOL 128 can include a self-sealing valve 134, which can be integrated with the bladder 130. The self-sealing valve 134 can be coupled to the bladder 130. Matter (e.g., fluid and / or gas) can be introduced into the inner reservoir 132 of the bladder 130 through the self-sealing valve 134. A tube, such as a needle, can be inserted through the self-sealing valve 134 to introduce matter into the inner reservoir 132. The self-sealing valve 134 can form a seal around the tube, which can prevent leakage out of matter out of the bladder 130 when filling the inner reservoir 132. The self-sealing valve 134 can automatically close when the tube is removed to prevent leakage of matter out of the bladder 130. The self-sealing valve 134 can be a duckbill valve. The duckbill valve can allow matter to be injected into the innerreservoir 132 but prevent backflow out of the inner reservoir 132. The duckbill valve can open when external pressure is applied and seal tightly when that external pressure is released. The self-sealing valve 134 can be a flap valve, umbrella valve, or slit valve. The self-sealing valve 134 can be biased closed, which can include being biased closed at one end. The self-sealing valve 134 can include one or more surfaces (e.g., flaps, sheets) that are biased toward each other to seal the inner reservoir 132 closed.

[0097] The IOL 128 (e.g., bladder 130 and / or self-sealing valve 134) can be made of one or more biocompatible materials such as silicone, hydrophilic acrylic, and / or other suitable polymers. The one or more biocompatible materials can be flexible, clear, and / or biocompatible. The one or more biocompatible materials can provide optical clarity, flexibility (e.g., flexibility for a compliant bladder 130), and / or long-term biocompatibility, which can prevent adverse reactions within the eye 100. The one or more biocompatible materials can be resistant to protein deposits and / or other forms of degradation over time.

[0098] FIG. 2A illustrates the IOL 128 in a deflated configuration with the selfsealing valve 134 closed. FIG. 2B illustrates the self-sealing valve 134 opened with matter 138 being introduced into the inner reservoir 132 of the bladder 130 by way of an opening 136 of the self-sealing valve 134. FIG. 2C illustrates the bladder 130 expanded (e.g., inflated) from the matter 138 flowing into the inner reservoir 13 through the opening 136 of the self-sealing valve 134. FIG. 2D illustrates the bladder 130 filled (e.g., inflated) to an expanded configuration with the self-sealing valve 134 closed to retain the matter 138 within the inner reservoir 132.

[0099] The refractive power of the IOL 128 can be adjusted by adjusting the quantity of matter (e.g. fluid and / or gas) within the bladder 130. For example, matter can be added into or removed from the inner reservoir 132 to adjust (e.g., finely tune) the refractive power of the IOL 128, which can include adding or removing matter 138 from the inner reservoir 132 by way of the self-sealing valve 134 with the IOL 128 disposed in the capsular bag 106. In some variants, the refractive power can be adjusted in small increments (e.g., plus or minus 0.05 diopters), which can enable highly personalized vision correction tailored to the specific needs of the patient. In some variants, the refractive power can be adjusted along a continuum. In some variants, a surgeon can use real-time intraoperative aberrometry to adjust (e.g., fine tune) the refractive power of the IOL 128, which can improve outcomes.

[0100] FIGS. 3A-3H illustrate a method of implanting the IOL 128 within the capsular bag 106 of the eye 100. As illustrated in FIG. 3A, one or more small openings 112 (e.g., one or two small openings) can be cut in an anterior portion of the capsular bag 106, which can be off an optical axis of the eye 100. In some variants, the one or more small openings 112 can be outside the optical zone. The one or more small openings 112 can be a variety of sizes, which can include 2-3 millimeters (e.g., 2-3 millimeters in diameter). This smaller size compared to a capsulorhexis can reduce damage to the capsular bag 106, reduce surgical trauma, minimize a risk of infection, and / or speed up a patient’s recovery time.

[0101] As illustrated in FIG. 3B, the IOL 128 with the bladder 130 deflated (e.g., collapsed) can be inserted into the capsular bag 106 through the one or more small openings 112. For example, a delivery device 142 (e.g., injector, tube) can be inserted into the capsular bag 106 through the one or more small openings 112 and the IOL 128 can be urged out of the delivery device 142 and into the capsular bag 106. The IOL 128 with the bladder 130 can be folded, rolled, and / or otherwise compacted to reduce volume to facilitate insertion into the capsular bag 106 through the one or more small openings 112 and / or placement within the delivery device 142. The IOL 128 with the deflated bladder 130 in the capsular bag 106 can be positioned as illustrated in FIG. 3C. For example, a tool, such as a specialized instrument and / or the delivery device 142, can be used to precisely place and / or verify the correct positioning of the IOL 128, which can be prior to filling the bladder 130 with matter (e.g., fluid and / or gas). The IOL 128 can be positioned, as shown in FIG. 3D, with the self-sealing valve 134 accessible, which can include facing an anterior direction (e.g., positioned facing the front of the eye 100).

[0102] As shown in FIG. 3E, a needle 144 and / or other instrument (e.g., tube) can be inserted through the opening 136 of the self-sealing valve 134 into the inner reservoir 132 of the bladder 130. The self-sealing valve 134 can form a seal around (e.g., close around) the needle 144 to prevent matter (e.g., fluid and / or gas) leaking out of the bladder 130. Matter 138 (e g., fluid and / or gas) can flow (e.g., be injected) into the inner reservoir 132 through the needle 144 to expand (e.g., inflate) the bladder 130 as illustrated in FIG. 3F. As described herein, the bladder 130 can be fdled with different amounts of matter 138 (e.g., fluid and / or gas) to achieve different refractive powers. Matter 138 can be removed from the bladder 130 by way of the needle 144 to achieve different refractive powers. With the inner reservoir 1 2filled with a quantity of matter 138 for a target refractive power, the needle 144 can be removed, as illustrated in FIGS. 3G and 3H. The self-sealing valve 134 (e.g., opening 136) can automatically close as the needle 144 is removed to retain the matter 138 within the inner reservoir 132 of the bladder 130.

[0103] FIG. 4A illustrates an IOL 129, which can include any of the features of IOL 128. The IOL 129 can include a bladder 146, which can also be referred to as sack, pouch, balloon, and / or bag. The bladder 146 can be shaped. The bladder 146 can have a shape that corresponds to the natural lens of the eye 100, which can include mimicking a shape of the natural lens of the eye 100.

[0104] The bladder 146 can include a wall (e.g., peripheral wall), which can include a first portion 150 (e.g., first half) and a second portion 152 (e.g., second half). The wall can have a uniform thickness. The first portion 150 and second portion 152 can be joined at a seam 158, which can also be referred to as ajoint. The seam 158 can extend circumferentially around the bladder 146. The first portion 150 can be a first sheet of material. The second portion 152 can be a second sheet of material. The first portion 150 and the second portion 152, when coupled together (e.g., adhered together at the seam 158), can form the bladder 146. The first portion 150 and / or second portion 152 can include various shapes, which can at least include circular, dome, hemisphere, hemispheroid, and / or other shapes. The first portion 150 can define an anterior portion (e.g., half). The second portion 152 can define a posterior portion (e.g., half).

[0105] As described herein, the IOL 129 can be placed in the capsular bag of a patient and filled with a fluid (e.g., liquid and / or gas) to fill the capsular bag, which can avoid postoperative contraction of the capsular bag and / or mimic a size and / or shape of the natural lens of the patient that was removed. The IOL 129 can be responsive to ocular forces applied to the capsular bag to accommodate. For example, the IOL 129 can be reshaped when subject to ocular forces (e.g., flattened when the zonules are tensioned for distance focus or rounded when the zonules relax for near focus), which can enable the IOL 129 to accommodate (e.g., change its optical power in response to ocular forces). The reshaping can alter the shape (e.g., curvature) of the surfaces (e.g., anterior and / or posterior) of the IOL 129 (e.g., bladder 146) to change optical power of the IOL 129 (e.g., change how light is refracted and / or diffractive) through the IOL 129. The IOL 129 (e.g., fluid fdled bladder 146) can be non-rigid (e.g.,compliant) to facilitate an accommodative response to the ocular forces as described. For example, the bladder 146 can be made of a material that is non-rigid, which can include a material with a refractive index less than 1.5 (e.g., 1.3, less than 1.3, 1.4 less than 1.4). The bladder 146 can be fdled with a fluid (e.g., liquid or gas) having a refractive index less than 1.5 (e g., 1.3, less than 1.3, 1.4 less than 1.4). For example, silicone can be used for the bladder 146 and / or fluid. In some variants, the fluid can include saline (e.g., refractive index of 1.33). The fluid filled bladder 146 can provide a base power for the IOL 129, which can be altered by adjusting the fill amount of the bladder 146 (e.g., fill more or less). The base power can be adjusted by the reshaping of the bladder 146 by the ocular forces, which can be an accommodating power change.

[0106] The IOL 129 can include features (e.g., surface patterns, surface features) to amplify the accommodating power changes (e g., dioptric power) provided by the IOL 129. For example, an anterior portion 151 of the IOL 129, such as the anterior portion of the peripheral wall of the bladder 146 (e.g., first portion 150), can include features to increase the power (e.g., dioptric power) provided by the IOL 129. The features can be disposed on (e.g., formed in, incorporated with) an anterior and / or posterior surface of the portion 151. In some variants, a posterior portion of the IOL 129, such as the posterior portion of the peripheral wall of the bladder 146 (e.g., second portion 152), can include features to increase the power (e.g., dioptric power) provided by the IOL 129. The features can be disposed on (e.g., formed in, incorporated with) an anterior and / or posterior surface of the portion 152. The features can include refractive and / or diffractive lens characteristics. The features can include surface patterns (e.g., curves, rings, grooves, edges, annular features, contours, ridges, angles, cuts, steps, and / or others). The power changes provided by the features can be linear or non-linear. The features can amplify power changes provided by the IOL 129 from the application of ocular forces (e.g., forces from the zonules). In some variants, the features can include zones of power to provide different powers at different radial positions. In some variants, the features can provide multifocal characteristics. In some variants, the features can include extended depth of focus characteristics. The reshaping of the IOL 129 from ocular forces and the features to amplify accommodating power changes can cooperate together to provide a greater range of optical powers.

[0107] In some variants, the features can include a refractive monofocal optic, which can include a smooth, single continuous curvature. In some variants, the features can include an extended depth of focus lens (e.g., EDOF), which can include elongated and / or asymmetric anterior curvature (e.g., slightly elongated and / or asymmetric anterior curvature) — not stepped. In some variants, the features can include a refractive multifocal lens, which can include distinct concentric refractive zones such as step-like curvature changes (e.g., progressive - slower and continuous radii changes across a radius of the lens). In some variants, the features can include a diffractive multifocal lens, which can include an anterior surface with diffractive ringlets (e.g., fine stepped pattern). In some variants, the features can include a toric lens, which can be similar to a monofocal but with asymmetric curvature in one meridian (e.g., astigmatism-correcting). The features can magnify the ability of the IOL 129 to accommodate in response to ocular forces being applied to the IOL 129.

[0108] The IOL 129 can include a self-sealing valve 148, which can at least include a duckbill valve, flap valve, umbrella valve, and / or slit valve. The self-sealing valve 148 can be disposed at the seam 158, which can include the seam 158 being formed around the selfsealing valve 148. As illustrated in FIG. 4B, the self-sealing valve 148 can include a tube 156 and / or self-sealing portion 154. The tube 156 can extend out of the bladder 146. The tube 156 can extend through the seam 158. The seam 158 can be formed around the tube 156. The tube 156 can extend into an inner reservoir 160 (e g., cavity) of the bladder 146. The self-sealing portion 154 can be disposed inside the inner reservoir 160. The self-sealing portion 154 can be disposed on the side of the tube 156 inside the inner reservoir 160 such that the self-sealing portion 154 is disposed inside the inner reservoir 160. In some variants, the self-sealing portion 154 can be disposed outside the inner reservoir 160.

[0109] FIGS. 5A-5D illustrate the self-sealing portion 154 separate from the tube 156 with non-limiting example dimensions. As shown, the self-sealing portion 154 can include a first end 162 and a second end 164. The first end 162 can be configured to couple with the tube 156. The first end 162 can be adhered (e.g., bonded) to the tube 156. The first end 162 can be formed to have a circular opening that interfaces with the tube 156. In some variants, the circular opening of the first end 162 can receive the tube 156. The second end 164 can be biased closed, which can include two opposing surfaces being biased toward each other to form a seal. As illustrated in FIG. 5C, the outer profile of the self-sealing portion 154 can be taperedfrom the first end 162 to the second end 164. The self-sealing portion 154 can include various materials, which can at least include silicone (e.g., MED-4850). In use, the biased closed second end 164 of the self-sealing portion 154 can prevent matter (e.g., fluid and / or gas) within the inner reservoir 160 from leaking. A needle can be inserted into the tube 156 and pushed through the self-sealing portion 154 to overcome the biasing force closing the second end 164. The self-sealing portion 154 can form a seal (e.g., close around) the needle to prevent leakage as matter (e.g., fluid and / or gas) is introduced into or removed from the inner reservoir 160 by the needle. As the needle is removed, the self-sealing portion 154 can automatically close to prevent leaving.

[0110] FIGS. 6A-6F illustrate a method of manufacturing the self-sealing valve 148. FIG. 6A illustrates a first sheet 166 (e.g., leaflet) of material with non-limiting example dimensions. The first sheet 166 can have a rectangular periphery. FIG. 6B illustrates a second sheet 167 (e.g., leaflet) of material stacked on the first sheet 166. The first sheet 166 and second sheet 167 can be the same size and / or shape. The second sheet 167 and first sheet 166 can be stacked on top of each other such that the peripheries of the second sheet 167 and first sheet 166 are aligned. The stacked first sheet 166 and second sheet 167 can form a first lateral side 168 and a second lateral side 169. The first sheet 166 and the second sheet 167 can be coupled (e.g., bonded) together at the first lateral side 168 and second lateral side 169. For example, as shown in FIG. 6C, the first sheet 166 and second sheet 167 can be bonded together at the first lateral side 168. As shown in FIG. 6D, the first sheet 166 and second sheet 167 can be bonded together at the second lateral side 169. The first sheet 166 and second sheet 167 can be bonded together with a variety of materials, which can at least include room- temperature-vulcanizing (RTV) silicone (e.g., MED-1011 RTV adhesive). The bond can form rounded peripheral edges with the bonding material as shown. With the first lateral side 168 and the second lateral side 169 bonded, the first sheet 166 and second sheet 167 can form an assembly which can be shaped as shown in FIG. 6E. The bonded first sheet 166 and second sheet 167 can be biased open (e.g., biased apart from each other except at the bonded sides), which can include being biased to a circular opening, at one end of the assembly to form the first end 162 of the self-sealing portion 154. The first sheet 166 and second sheet 167 can be biased closed (e.g., biased toward each other) at the other end to form the second end 164 of the self-sealing portion 154. The first sheet 166 and second sheet 167 can be set in the shapedconfiguration illustrated in FIG. 6E to form the self-sealing portion 154. The self-sealing portion 154 can be coupled to the tube 156, as illustrated in FIG. 6F, which can include adhering (e.g., bonding) to the tube 156. With the self-sealing valve 148 assembled, silicone oil (e.g., MED 420) can be applied thereto.[OlH] To form the IOL 129, the first portion 150 and second portion 152 can be adhered together at the seam 158 with the tube 156 of the self-sealing valve 148 disposed between the first portion 150 and the second portion 152 at the seam 158 such that the selfsealing portion 154 of the self-sealing valve 148 is disposed within the inner reservoir 160 of the bladder 146 when formed. The IOL 129 can, in some variants, be shaped. The IOL 129 can be compacted (e.g., rolled, folded, etc.) for delivery into the capsular bag 106 of the eye 100. With the IOL 129 positioned, a needle or the like can be inserted through the tube 156 of the self-sealing valve 148. The needle can be advanced to push through the self-sealing portion 154 of the self-sealing valve 148. The self-sealing portion 154 can form a seal around the needle to prevent leakage. Matter (e.g., fluid and / or gas) can be urged into or removed from the inner reservoir 160 of the bladder 146 to fill the bladder 146 to an amount to achieve a target refractive power. With the appropriate amount of matter, the needle or the like can be removed with the self-sealing valve 148 automatically closing to prevent matter leaking out of the inner reservoir 160 of the bladder 146.

[0112] FIG. 7A illustrates a lens 174 (e.g., meniscus lens) disposed on (e.g., coupled to) a capsular bag 106 with the natural lens removed. The lens 174 can cover an opening 172 created to access the capsular bag 106 to remove the natural lens. As described herein, an opening 172 can be formed in a capsular bag 106 during cataract surgery to remove the clouded natural lens. Instead of replacing the natural lens with an IOL, matter 138 (e.g., fluid and / or gas) can be directly inserted (e.g., flowed, injected) into the capsular bag 106. A lens 174 can be disposed over the opening 172 to prevent matter 138 from escaping. The lens 174 can extend beyond the periphery of the opening 172. In some variants, the capsular bag 106 can be filled with matter 138 first and then the lens 174 can be placed over the opening 172 to prevent matter 138 from escaping. In some variants, the lens 174 can be placed over the opening 172 before filling the capsular bag 106 with matter 138. The lens 174 can include a self-sealing valve through which matter 138 can be added to or removed from the capsular bag 106. A needle or the like can be inserted through the self-sealing valve to add or removematter 138. A desired pressure within the capsular bag 106 can be achieved by adding or removing matter 138 through the self-sealing valve of the lens 174. In some variants, the lens 174 can be disposed within the capsular bag 106 and cover the opening 172. In some variants, the lens 174 can be disposed on an exterior of the capsular bag 106 and cover the opening 172. The lens 174 can include one or more features to prevent the lens 174 from inadvertently decoupling from the capsular bag 106, matter 138 leaking from the capsular bag 106, and / or the lens 174 migrating. For example, as illustrated in FIG. 7B, the lens 174 can include a peripheral portion 176 that can be biased in a direction to hold (e.g., grip) the lens 174 onto the capsular bag 106. In some variants, the lens 174 can be adhered to the capsular bag 106. In some variants, the lens 174 can include anchors to couple the lens 174 to anatomy such as the capsular bag 106.

[0113] FIGS. 8-12 illustrate features of various optics that can be incorporated into the IOLS (e.g., peripheral walls, such as anterior and / or posterior portions, of bladders, which can include surfaces thereof) described herein. The features can be used to amplify power adjustments provided by the IOLs described herein. One or more features of different optics can be incorporated into a single IOL. FIG. 8 illustrates a diffractive optic to provide near, intermediate, and distance focus, which can include having steps (e.g., stepped rings, grooves) features to provide non-linear power adjustments. FIG. 9 illustrates another diffractive optic. FIG. 10 illustrates another diffractive optic to show annular ridges and grooves. FIG. 11 illustrates a refractive multifocal optic. FIG. 12 illustrates a refractive multifocal optic. FIG. 13 illustrates a progress optic.Conclusion

[0114] In some variants, the IOLs described herein can be pre-shaped, which can set refractive power and / or prevent movement of the IOL from a desired position and / or orientation. In some variants, the amount of matter (e.g., fluid and / or gas) in the IOLs described herein can be adjusted preimplantation, during implantation, and / or postimplantation. The IOLs described herein can, in some variants, include various bladder sizes for various diopters. In some variants, the IOLs described herein can include an overall diameter of 10-15 millimeters, which can include a nominal diameter of 12-13 millimeters. In some variants, the IOLs described herein can include a clear diameter of 4-1 millimeters,which can include a nominal diameter of 5.5-7.5 millimeters. In some variants, the IOLS described herein can be biconvex, planoconvex, planoconcave, equiconvex, biconcave, and others. The IOLs described herein can include various materials, which can at least include hydrophobic, hydrophilic, silicone, biodegradable, combination materials, materials with a variable refractive index, and / or others. The IOLs described herein can include various patterns to address base refraction, extended depth of focus, astigmatism / toric, multifocal zones (e.g., diffractive or refractive, pupil controlled such as pin-hole), and / or others. In some variants, the bladders described herein can include patterns, which can be rotationally symmetric or asymmetric. In some variants, the IOLs described herein can include a coating, which can include a coating on an exterior and / or interior surface. The coating(s) and / or pattern(s) can, in some variants, improve biocompatibility. In some variants, the IOLs described herein can include one or more drugs (e g., antibiotics, steroids, anti-infective, intraocular pressure reducing, etc.). In some variants, the IOL can include a drug-eluting reservoir, which can be disposed at the valve of the IOL and / or sections of the IOL (e.g., bladder regions).

[0115] The IOLs described herein, which can include the bladders, can incorporate various optical features to enhance visual performance. The IOLs can include multifocality. The IOLs can include multiple focal zones, which can provide improved vision at different distances (e.g., near, intermediate, and / or far) such that dependence on glasses and / or contact lenses can be reduced. The multifocal zones can be arranged in concentric rings and / or a segmented pattern, which can depend on the desired visual outcome. The IOLs can include specialized optical elements to provide extended depth of focus, which can improve vision quality across a broad range of distances and / or reduce visual disturbances. The specialized optical elements can at least include aspheric surfaces, gradient index optics, and / or other techniques to modulate how light is focused on the retina, enhance depth of field, and / or reduce spherical aberrations. The IOLs can include diffractive optical elements, which can include diffractive patterns that can be integrated into the surface (e.g., bladder surface) to enhance light distribution, enhance focus, reduce glare, and / or reduce halos. The diffractive patterns can be fine-tuned to control the diffraction of light and / or improve the distribution of light to the various focal points, which can be particularly beneficial in low light conditions and / or when high contrast is desired.

[0116] The surface of the IOL, such as the bladder surface, can include patterns and / or coatings to improve optical performance and / or biocompatibility. The patterns can be etched and / or molded into the surface, which can enhance light distribution, reduce aberrations, and / or improve visual clarity. The patterns can at least include micro-grooves, nano-patterns, and / or textured surfaces. The patterns can, in some variants, manipulate light at a microstructural level. In some variants, the surface coating(s) of the IOL can reduce glare. In some variants, the IOLS described herein can include anti-reflective coatings, which can reduce reflections and / or improve light transmission to enhance visual clarity and / or reduce glare. Antireflective coatings can be beneficial at least for patients who experience glare and / or halos from bright lights. In some variants, the IOLs described herein can include hydrophobic and / or hydrophilic coatings. Depending on application, these coatings can improve wettability, reduce deposits, and / or maintain clarity. Hydrophobic coatings can repel water and / or reduce adherence of proteins and / or lips. Hydrophilic coatings can improve comfort and / or reduce friction with the eye’ s tissues. In some variants, the IOLs described herein can include an anti- infective coating, which can include anti-infective agents to prevent postoperative infections and / or improve long-term safety and / or efficacy. The anti-infective coating can continuously release antibiotics and / or other anti-infective agents to provide ongoing protection against microbial contamination. In some variants, the IOLs described herein can include a protective coating and / or surface treatment, which can enhance scratch resistance and / or durability to improve long-term optical performance.

[0117] The IOLs described herein can include reservoirs, such as micro reservoirs, for controlled therapeutic (e.g., medicament, drug) release. These reservoirs can be preloaded with medicaments such as anti-inflammatory agents (e.g., steroids such as dexamethasone), antibiotics (e.g., ciprofloxacin and / or moxifloxacin), anti-infective agents, antifungal agents, antiviral agents, and / or intraocular pressure-reducing agents (e.g., prostaglandin analogs and / or beta-blockers). In some variants, the IOLs described herein can include various mechanisms for a controlled release of one or more medicaments, which can at least include biodegradable coating(s), osmotic pump(s), and / or stimuli-responsive material(s). The biodegradable coating(s) can degrade over time to release a medicament gradually. The osmotic pump(s) can release the medicament at a controlled rate based on osmotic pressure. The stimuli-responsive materials can release a medicament in response to a specific trigger,such as changes in pH, temperature, and / or light. The IOLS described herein can include features to reduce the risk of posterior capsule opacification. The IOLs described herein can include features to maintain stable optical properties over time, which can include reducing a likelihood of refractive regression and / or the need for secondary interventions.

[0118] The IOLs described herein can, in some variants, include an optical alignment guide, which can include a marking system. The optical alignment guide can include one or more markings to facilitate accurate positioning and / or alignment during surgical procedure.

[0119] The IOLs described herein can, in some variants, include a surface (e.g., material, pattern, texture, etc.) that promotes tissue integration and / or biocompatibility, which can reduce a risk of rejection and / or adverse reactions within an eye.

[0120] In some variants, the IOLs described herein can include a single-piece design, which can simplify the implantation process and / or reduce a risk of component dislocation and / or misalignment. In some variants, the IOLs described herein can include a modular design that can permit different components to be assembled within the eye, which can provide flexibility in lens configuration and / or facilitate additional customization.

[0121] The IOLs described herein can be manufactured using a variety of techniques, which can ensure high precision and / or biocompatibility. The manufacturing techniques can at least include injection molding, 3D printing, and / or laser cutting. The manufacturing techniques can be used to create the bladder, which can include surface features.

[0122] Although the systems and methods have been disclosed in the context of certain embodiments and examples, it will be understood by those skilled in the art that the systems and methods extend beyond the specifically disclosed embodiments to other alternative embodiments and / or uses of the embodiments and certain modifications and equivalents thereof. Various features and aspects of the disclosed embodiments can be combined with or substituted for one another in order to form varying modes of the thermal systems, devices, and methods disclosed herein. The scope of this disclosure should not be limited by the particular disclosed embodiments described herein.

[0123] Methods of using the foregoing system(s) (including device(s), apparatus(es), assembly(ies), structure(s) or the like) are included; the methods of use can include using or assembling any one or more of the features disclosed herein to achievefunctions and / or features of the system(s) as discussed in this disclosure. Methods of manufacturing the foregoing system(s) are included; the methods of manufacture can include providing, making, connecting, assembling, and / or installing any one or more of the features of the system(s) disclosed herein to achieve functions and / or features of the system(s) as discussed in this disclosure.

[0124] Certain features that are described in this disclosure in the context of separate implementations can also be implemented in combination in a single implementation. Conversely, various features that are described in the context of a single implementation can also be implemented in multiple implementations separately or in any suitable subcombination. Moreover, although features may be described above as acting in certain combinations, one or more features from a claimed combination can, in some cases, be excised from the combination, and the combination may be claimed as any subcombination or variation of any subcombination.

[0125] Moreover, while operations may be depicted in the drawings or described in the specification in a particular order, such operations need not be performed in the particular order shown or in sequential order, and all operations need not be performed, to achieve the desirable results. Other operations that are not depicted or described can be incorporated in the example methods and processes. For example, one or more additional operations can be performed before, after, simultaneously, or between any of the described operations. Further, the operations may be rearranged or reordered in other implementations. Also, the separation of various system components in the implementations described above should not be understood as requiring such separation in all implementations, and it should be understood that the described components and systems can generally be integrated together in a single product or packaged into multiple products. Additionally, other implementations are within the scope of this disclosure.

[0126] Conditional language, such as “can,” “could,” “might,” or “may,” unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include or do not include, certain features, elements, and / or steps. Thus, such conditional language is not generally intended to imply that features, elements, and / or steps are in any way required for one or more embodiments.

[0127] Conjunctive language, such as the phrase “at least one of X, Y, and Z,” unless specifically stated otherwise, is otherwise understood with the context as used in general to convey that an item, term, etc. may be either X, Y, or Z. Thus, such conjunctive language is not generally intended to imply that certain embodiments require the presence of at least one of X, at least one of Y, and at least one of Z.

[0128] Some embodiments have been described in connection with the accompanying drawings. Components can be added, removed, and / or rearranged. Orientation references such as, for example, “top” and “bottom” are for ease of ease of discussion and may be rearranged such that top features are proximate the bottom and bottom features are proximate the top. Further, the disclosure herein of any particular feature, aspect, method, property, characteristic, quality, attribute, element, or the like in connection with various embodiments can be used in all other embodiments set forth herein. Additionally, it will be recognized that any methods described herein may be practiced using any device suitable for performing the recited steps.

[0129] In summary, various embodiments and examples of thermal systems, devices, and methods have been disclosed. Although the systems and methods have been disclosed in the context of those embodiments and examples, it will be understood by those skilled in the art that this disclosure extends beyond the specifically disclosed embodiments to other alternative embodiments and / or other uses of the embodiments, as well as to certain modifications and equivalents thereof. This disclosure expressly contemplates that various features and aspects of the disclosed embodiments can be combined with, or substituted for, one another. Accordingly, the scope of this disclosure should not be limited by the particular disclosed embodiments described above, but should be determined only by a fair reading of the claims that follow.

Claims

WHAT IS CLAIMED IS:

1. An intraocular lens comprising: a bladder configured to hold fluid, the bladder comprising a peripheral wall with one or more features to amplify a dioptric power provided by the intraocular lens; and a self-sealing valve through which fluid is configured to be introduced into the bladder to inflate the bladder with the intraocular lens positioned in a capsular bag of an eye; wherein the bladder, when holding the fluid, is configured to be compliant such that the bladder reshapes in response to ocular forces.

2. The intraocular lens of Claim 1, wherein the self-sealing valve is a duckbill valve.

3. The intraocular lens of any of the preceding claims, wherein the self-sealing valve is configured to form a seal around a needle inserted through the self-sealing valve to add or remove fluid.

4. The intraocular lens of any of the preceding claims, wherein the bladder is preshaped.

5. The intraocular lens of any of the preceding claims, wherein the peripheral wall of the bladder comprises a uniform thickness.

6. The intraocular lens of Claim 5, wherein the peripheral wall is disposed at an anterior-facing portion and a posterior-facing portion of the bladder.

7. The intraocular lens of Claim 6, wherein the peripheral wall extends circumferentially about an optical axis of the intraocular lens.

8. The intraocular lens of any of the preceding claims, wherein the bladder is configured to be rolled up without fluid introduced into the bladder.

9. The intraocular lens of any of the preceding claims, wherein the bladder is configured to be folded up without fluid introduced into the bladder.

10. The intraocular lens of any of the preceding claims, wherein the self-sealing valve comprises two or more surfaces that are biased toward each other to form a seal.

11. The intraocular lens of any of the preceding claims, wherein the self-sealing valve includes a tube and a sealing portion, the tube extending from outside the bladder to within an inner reservoir of the bladder.

12. The intraocular lens of Claim 11 , wherein the sealing portion comprises two sheets biased toward each other to provide a seal.

13. The intraocular lens of Claim 12, wherein lateral edges of the two sheets are bonded together.

14. The intraocular lens of any of Claims 11-13, wherein the sealing portion is disposed inside the inner reservoir.

15. The intraocular lens of any of the proceeding claims, wherein the bladder is configured to hold different quantities of fluid to provide different refractive powers.

16. The intraocular lens of any of the proceeding claims, wherein the bladder comprises silicone.

17. The intraocular lens of any of the proceeding claims, wherein the fluid is saline.

18. The intraocular lens of any of the proceeding claims, wherein the intraocular lens includes one or more reservoirs of a therapeutic.

19. The intraocular lens of Claim 18, wherein the one or more reservoirs are configured to release the therapeutic in a controlled manner within the eye.

20. The intraocular lens of any of the preceding claims, wherein the fluid comprises a fluid.

21. The intraocular lens of any of the preceding claims, wherein the fluid comprises a gas.

22. The intraocular lens of any of the preceding claims, wherein the bladder is configured to be flattened when zonules of the eye are tensioned and rounded when the zonules of the eye are relaxed.

23. The intraocular lens of any of the preceding claims, wherein the bladder comprises a material having a refractive index that is less than 1.5.

24. The intraocular lens of any of the preceding claims, wherein the fluid comprises a material having a refractive index that is less than 1.5.

25. The intraocular lens of any of the preceding claims, wherein the one or more features comprise refractive monofocal optic characteristics.

26. The intraocular lens of any of the preceding claims, wherein the one or more features comprise extended depth of focus optic characteristics.

27. The intraocular lens of any of the preceding claims, wherein the one or more features comprise refractive multifocal optic characteristics.

28. The intraocular lens of any of the preceding claims, wherein the one or more features comprise diffractive multifocal optic characteristics.

29. The intraocular lens of any of the preceding claims, wherein the one or more features comprise toric optic characteristics.

30. A method of implanting an intraocular lens within a capsular bag of a patient, the method comprising: reducing a volume of a bladder of the intraocular lens; placing the intraocular lens into the capsular bag through an opening in the capsular bag; positioning the intraocular lens such that a self-sealing valve of the intraocular lens is accessible; inserting a needle through the self-sealing valve; injecting fluid into an inner reservoir of the bladder through the needle; and removing the needle such that the self-sealing valve closes to impede the fluid from leaking.

31. The method of Claim 30, wherein reducing the volume of the bladder comprises rolling up the bladder.

32. The method of Claim 30, wherein reducing the volume of the bladder comprises folding the bladder.

33. The method of any of Claims 30-32, further comprising cutting the opening in the capsular bag.

34. The method of Claim 33, wherein the opening comprises a diameter of 2-3 millimeters.

35. A method of forming an intraocular lens, the method comprising: stacking two sheets on top of each other; bonding lateral edges of the two sheets together to form an assembly; shaping a first end of the assembly to form an opening; coupling a tube to the first end of the assembly; andbonding a first sheet and a second sheet together with the tube disposed therebetween such that the tube extends out from between the first sheet and the second sheet to within an inner reservoir between the bonded first sheet and the second sheet.

36. The method of Claim 35, wherein the first sheet and the second sheet each comprise a circular shape.

37. A method of performing cataract surgery, the method comprising: removing a natural lens from a capsular bag of an eye through an opening in the capsular bag; flowing a fluid into the capsular bag through the opening; and placing a lens over the opening to impede the fluid from leaking out of the capsular bag.

38. The method of Claim 37, wherein placing the lens over the opening comprises inserting the lens inside the capsular bag.

39. The method of Claim 37 or 38, further comprising coupling the lens to the capsular bag.

40. The method of Claim 39, wherein coupling the lens comprises adhering the lens to the capsular bag.

41. The method of Claim 39 or 40, wherein coupling the lens comprises securing the lens to the capsular bag with one or more anchors of the lens.

42. The method of any of Claims 39-41, wherein coupling the lens comprises positioning a biased periphery of the lens to interface with the capsular bag.

43. The method of any of Claims 37-42, further comprising coupling the lens to anatomy of the eye with one or more anchors.

44. The method of any of Claims 37-43, wherein the lens is a meniscus lens.

45. The method of any of Claims 37 and 39-44, wherein placing the lens over the opening comprises positioning the lens at an exterior of the capsular bag.

46. A method of performing cataract surgery, the method comprising: removing a natural lens from a capsular bag of an eye through an opening in the capsular bag; placing a lens over the opening; inserting a needle through a self-sealing valve of the lens; andinjecting fluid into the capsular bag; and removing the needle from the self-sealing valve.

47. The method of Claim 46, wherein the fluid is saline.

48. The method of Claim 46 or 47, wherein the lens is a meniscus lens.

49. The method of any of Claims 46-48, wherein placing the lens over the opening comprises positioning the lens within the capsular bag.

50. The method of any of Claims 46-48, wherein placing the lens over the opening comprises positioning the lens at an exterior of the capsular bag.

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