Hygroscopic composition and cosmetic

Abstract

The present invention relates to a cosmetic containing (A) sucrose and (B) sodium chloride. The inventors successfully developed a moisturizing ingredient capable of sufficiently improving the water-retaining capability of the stratum corneum, which is a barrier layer of the skin.

Description

Hygroscopic composition and cosmetic

[0001] The present invention relates to a composition and a cosmetic having hygroscopic properties.

[0002] Since moisture is deeply involved in maintaining youthful skin, various moisturizing ingredients are blended into cosmetics, such as pyrrolidone carboxylate, a type of natural moisturizing factor, intercellular lipid components, oily components, polyhydric alcohols, and sodium hyaluronate (Non-Patent Document 1).

[0003] Takeo Mitsui, Moisturizers, New Cosmetics (Nanzando), pp. 143-147 (1993)

[0004] One embodiment of the present invention is a composition containing (A) sucrose and (B) sodium chloride, which has a deliquescence onset humidity of 72% RH or less at 20°C. Another embodiment of the present invention is a composition containing (A) sucrose, (B) sodium chloride, and (C) serine, which has a deliquescence onset humidity of 67% RH or less at 35°C. Another embodiment of the present invention is a moisture absorbent composition or moisturizer composition containing (A) sucrose and (B) sodium chloride. Another embodiment of the present invention is a moisture absorbent composition or moisturizer composition containing (A) sucrose, (B) sodium chloride, and (C) serine. Another embodiment of the present invention is a cosmetic containing (A) sucrose and (B) sodium chloride. Another embodiment of the present invention is a cosmetic containing (A) sucrose, (B) sodium chloride, and (C) serine.

[0005]

[0033] Figure 1 shows the criteria for determining deliquescence. Figure 2 shows the range in which excellent deliquescence and water absorbency are obtained when the results of Table 1 are plotted as a three-phase diagram. Figure 3 shows the range in which excellent deliquescence and water absorbency are obtained when the results of Table 2 are plotted as a three-phase diagram. Figure 4 shows the range in which even better deliquescence and water absorbency are obtained when the results of Table 2 are plotted as a three-phase diagram. Figure 5 shows the effect of a composition (aqueous solution) containing sucrose, sodium chloride, and serine on the moisture content of the stratum corneum. Figure 6 shows the changes in moisture content of the stratum corneum after 1 hour and 8 hours for the cases of a single sucrose component, a two-component composition (sucrose and sodium chloride), and a three-component composition (sucrose, sodium chloride, and serine). Red: molar amount the same as in Example 1. Blue: molar amount the same as in Example 8. Detailed Description of the Invention

[0006] Terms used in this specification are used in the sense commonly used in the art unless otherwise specified.

[0007] As used herein, deliquescence refers to the phenomenon in which a substance absorbs moisture from the air and spontaneously turns into an aqueous solution. In other words, a substance with high deliquescence can spontaneously hold water and can be said to have high water retention capacity. The deliquescence onset humidity refers to the relative humidity at which a test component or a mixture of test components begins to deliquesce. Here, the deliquescence onset humidity is measured under conditions of 20°C to 35°C and 1 atmosphere. Specifically, the 72% RH condition is 20°C, and the 67% RH condition is 35°C. More specifically, the test components (total amounts of (A), (B), and (C)) were mixed in powder form, and a water absorption of 0.015 g or more per 1000 μmol of test component was determined to be deliquescent when measured under conditions of 72% RH for three days. Furthermore, a high deliquescence was determined when a water absorption of 0.015 g or more per 1000 μmol of test component was measured under conditions of 67% RH for three days.

[0008] Conventional moisturizing ingredients are not capable of sufficiently improving the water-retaining capacity of the stratum corneum, which is the skin's barrier layer, and the development of even better moisturizing ingredients is desired.

[0009] The present inventors have measured the moisture absorption capacity of ingredients that can easily penetrate the skin and found that when a composition has excellent deliquescence, it significantly improves the moisturizing state of the stratum corneum, and when the composition is applied to the skin, an excellent moist feeling can be obtained. Furthermore, they have found the composition ratio that allows a mixture of sucrose and sodium chloride to absorb moisture from the air and deliquesce under a humidity condition of 72% RH or less. Furthermore, they have found that when serine is added in addition to sucrose and sodium chloride, it has the function of absorbing moisture from the air and deliquescing under a humidity condition of 67% RH or less.

[0010] The composition of the present invention has high moisture absorption capacity and is useful in various fields as a moisture absorbent, desiccant, moisturizer, etc. Furthermore, a cosmetic containing the composition of the present invention is a cosmetic that significantly improves the moisturizing state of the stratum corneum and imparts an excellent moist feeling to the skin to which it is applied, resulting in a pleasant feel when used.

[0011] One aspect of the present invention is a composition containing (A) sucrose and (B) sodium chloride, which has a deliquescence onset humidity of 72% RH or less at 20°C. Component (A) contained in the composition of the present invention is sucrose. Sucrose, also known as cane sugar, is a disaccharide in which glucose and fructose are linked via an α-1,2-glycosidic bond. Sucrose alone does not exhibit deliquescence. Sodium chloride (B), a sodium chloride, is known to deliquesce at a relative humidity of approximately 80%, but it is not known that mixing it with sucrose in a specific ratio reduces the deliquescence onset humidity. As described in the Examples below, a mixture of (A) sucrose and (B) sodium chloride absorbs moisture from the air and deliquesces at a relative humidity of 72%. Therefore, one aspect of the present invention is a composition containing (A) sucrose and (B) sodium chloride, which has a deliquescence onset humidity of 72% or less. Furthermore, a composition containing (A) sucrose and (B) sodium chloride has excellent deliquescence and therefore absorbs water, making it useful as a moisture absorbent. Therefore, another aspect of the present invention is a moisture-absorbing composition containing (A) sucrose and (B) sodium chloride. Due to the same effect, the composition can also be used as a moisturizer.

[0012] From the viewpoint of obtaining excellent deliquescence, the molar ratio (A / B) of component (A) to component (B) in the composition of the present invention is preferably 0.1 to 10, more preferably 0.2 to 6, and even more preferably 0.25 to 5. From the viewpoint of obtaining excellent deliquescence, the total content of component (A) and component (B) in the composition of the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.4% by mass or more, and even more preferably 0.5% by mass or more. The upper limit of this total amount is 100% by mass.

[0013] The composition of the present invention can contain various components as long as they do not adversely affect the deliquescence. However, if component (A) and component (B) are present in a particulate state, they need only be in contact with each other. Furthermore, as long as the component does not excessively absorb the surrounding moisture, various other components can be present together. For example, various porous carriers, acids, bases, etc. can be present together.

[0014] Another aspect of the present invention is a composition containing (A) sucrose, (B) sodium chloride, and (C) serine, which has a deliquescence onset humidity of 67% RH or less at 35°C. Serine is an amino acid and is not known to have deliquescent properties. L-serine is preferred as the serine. As described in the Examples below, when serine is added in addition to sucrose and sodium chloride, the composition absorbs moisture from the atmosphere and deliquesces at a humidity of 67% RH or less. Therefore, another aspect of the present invention is a composition containing (A) sucrose, (B) sodium chloride, and (C) serine, which has a deliquescence onset humidity of 67% RH or less at 35°C. Furthermore, a composition containing (A) sucrose, (B) sodium chloride, and (C) serine has excellent deliquescence and is therefore useful as a moisture absorbent or moisturizer. Therefore, another aspect of the present invention is a moisture absorbent composition or moisturizer composition containing (A) sucrose, (B) sodium chloride, and (C) serine.

[0015] In order to obtain excellent deliquescence, water absorption, hygroscopicity, and moisture retention, the molar ratio percentages of component (A) as (X), component (B) as (Y), and component (C) as (Z) in the composition of the present invention are preferably within the range surrounded by the following coordinates in a ternary phase diagram: (X, Y, Z) = (90, 10, 0), (10, 10, 80), (10, 90, 0), more preferably within the range surrounded by (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), (10, 80, 10), and even more preferably within the range surrounded by (X, Y, Z) = (50, 40, 10), (50, 20, 30), (20, 20, 60), (20, 70, 10). The molar ratio ((A) + (B) + (C)) / (A) of the total amount of components (A), (B), and (C) to the content of component (A) in the composition of the present invention is preferably 1 or more and 10 or less, more preferably 1.5 or more and 7 or less, and even more preferably 2 or more and 4 or less, from the viewpoint of obtaining excellent deliquescence, water absorption, hygroscopicity, and moisture retention. Furthermore, from the viewpoint of obtaining excellent deliquescence, water absorption, hygroscopicity, and moisture retention, the total content of components (A), (B), and (C) in the composition of the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.4% by mass or more, and even more preferably 0.5% by mass or more. The upper limit of this total amount is 100% by mass. More specifically, the total amount is preferably 0.05% by mass or more and 20% by mass or less, and even more preferably 0.5% by mass or more and 3% by mass or less. The total molar amount of components (A), (B), and (C) in the moisture-absorbent composition of the present invention is preferably 500 μmol or more, and more preferably 800 μmol or more, from the viewpoint of obtaining sufficient deliquescence, water absorption, and hygroscopicity. When the moisture-absorbent composition is in the form of fractions or individual forms such as capsules, from the viewpoint of ensuring surface area, the molar amount refers to the molar amount in each fraction or individual form. There is no particular upper limit to the total molar amount of components (A), (B), and (C) in the moisture-absorbent composition, but considering a convenient form, it is preferably 300 mmol or less, more preferably 30 mmol or less.

[0016] The composition of the present invention can contain various components as long as they do not adversely affect deliquescence, water absorption, hygroscopicity, moisture retention, etc. However, when components (A), (B), and (C) are present in particulate form, these three components need only be in contact with each other, and various components can be present as long as they do not excessively absorb surrounding moisture. For example, various porous carriers, acids, bases, etc. can be present.

[0017] Another aspect of the present invention is a cosmetic containing (A) sucrose and (B) sodium chloride. As shown in the examples below, a cosmetic containing these components (A) and (B) significantly improves the moisturizing state of the stratum corneum, and when applied to the skin, the cosmetic provides an excellent moist feeling.

[0018] The molar ratio (A / B) of component (A) to component (B) in the cosmetic of the present invention is preferably 0.1 to 10, more preferably 0.2 to 5, and even more preferably 0.25 to 4, from the viewpoint of improving the moisturizing state of the stratum corneum. Furthermore, the total content of component (A) and component (B) in the cosmetic of the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.4% by mass or more, and even more preferably 0.5% by mass or more, from the viewpoint of improving the moisturizing state of the stratum corneum. Furthermore, the upper limit of this total amount is preferably 15% by mass or less, more preferably 10% by mass or less, even more preferably 5% by mass or less, and even more preferably 2% by mass or less.

[0019] Another aspect of the present invention is a cosmetic containing (A) sucrose, (B) sodium chloride, and (C) serine. As shown in the examples below, a cosmetic containing these components (A), (B), and (C) significantly improves the moisturizing state of the stratum corneum, and when applied to the skin, the cosmetic provides an excellent moist feeling and can maintain this effect. Adding serine to components (A) and (B) can further moisturize the skin over time.

[0020] In terms of improving the moisturizing state of the stratum corneum, the molar ratio percentages of component (A) as (X), component (B) as (Y), and component (C) as (Z) in the cosmetic of the present invention are preferably within the range surrounded by the following coordinates (X, Y, Z) = (90, 10, 0), (10, 10, 80), and (10, 90, 0) in a ternary phase diagram, more preferably within the range surrounded by (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), and (10, 80, 10), and even more preferably within the range surrounded by (X, Y, Z) = (50, 40, 10), (50, 20, 30), (20, 20, 60), and (20, 70, 10).

[0021] The content of component (A) in the present invention is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and even more preferably 0.5% by mass or more, from the viewpoint of moist feeling. Furthermore, from the viewpoint of usability (reducing stickiness on the skin), it is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 2% by mass or less. From the viewpoint of moist feeling, the content of component (B) in the present invention is preferably 0.02% by mass or more, more preferably 0.04% by mass or more, even more preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more. Furthermore, from the viewpoint of reducing skin irritation, it is preferably 10% by mass or less, more preferably 3% by mass or less, even more preferably 1% by mass or less, and even more preferably 0.4% by mass or less. From the viewpoint of moist feeling and improving moisture content in the skin for a long time, the content of component (C) in the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and even more preferably 0.2% by mass or more. Furthermore, from the viewpoint of the feel upon use (reducing the feeling of tightness on the skin), the molar ratio ((A) + (B) + (C)) / (A) of the total amount of components (A), (B), and (C) to the content of component (A) in the cosmetic of the present invention is preferably 1 or more and 10 or less, more preferably 1.5 or more and 7 or less, and even more preferably 2 or more and 4 or less, from the viewpoint of improving the moisturizing state of the stratum corneum. Furthermore, from the viewpoint of improving the moisturizing state of the stratum corneum, the total content of components (A), (B), and (C) in the cosmetic of the present invention is preferably 0.16% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.25% by mass or more, and even more preferably 0.7% by mass or more. The upper limit of this total amount is preferably 20% by mass or less, more preferably 10% by mass or less, even more preferably 5% by mass or less, and even more preferably 3% by mass or less. The mass ratio ((A)+(B)) / (C) of the total content of components (A) and (B) to the content of component (C) in the cosmetic of the present invention is preferably 0.5 or more, more preferably 1 or more, and more preferably 2 or more, from the viewpoint of improving moist feeling and the moisture content of the skin for a long period of time.Moreover, from the viewpoint of improving the feeling of use such as creaking sensation, the mass ratio is preferably 25 or less, more preferably 20 or less, and even more preferably 10 or less.

[0022] The cosmetic composition of the present invention may be in any form as long as it contains the components (A) and (B), or the components (A), (B), and (C) in an aqueous phase, and examples of such forms include aqueous cosmetics such as lotions and emulsions, oil-in-water emulsion cosmetics, and water-in-oil cosmetics.

[0023] In addition to components (A), (B), and (C), the cosmetic of the present invention may contain surfactants, polyhydric alcohols, thickeners, oils, water, monohydric alcohols such as ethanol, preservatives, antioxidants, pigments, pH adjusters, fragrances, plant extracts, colorants, powders, ultraviolet absorbers, other moisturizers, blood circulation promoters, cooling agents, antiperspirants, disinfectants, skin activators, and the like.

[0024] The surfactant may be an ionic surfactant or a nonionic surfactant. Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkanol ether, polyglycerin fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan beeswax, and glycolipids. Among these, from the viewpoints of emulsion stability and usability, it is preferable to include one or more selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyoxyethylene fatty acid ester, more preferably one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether, and even more preferably polyoxyethylene hydrogenated castor oil. Examples of ionic surfactants include hydrogenated soybean phospholipid, egg yolk lecithin, acyl glutamate, sodium surfactin, and acyl sulfate.

[0025] When the cosmetic of the present invention is an oil-in-water emulsion composition, it is preferable to use a nonionic surfactant. The HLB of the nonionic surfactant is preferably 9 to 18, and from the viewpoint of causing a change in the feel of the cosmetic during application, an HLB of 11 to 16 is more preferable, and an HLB of 12 to 15 is even more preferable. Furthermore, when the cosmetic of the present invention is a water-in-oil emulsion composition, it is preferable to use a nonionic surfactant. The HLB of the nonionic surfactant is preferably 1 to 9, more preferably an HLB of 2 to 8, and even more preferably an HLB of 3 to 7.

[0026] Here, HLB (hydrophilic-lipophilic balance) indicates the molecular weight of the hydrophilic group portion relative to the total molecular weight of the surfactant, and is calculated using Griffin's formula. When a surfactant is composed of two or more nonionic surfactants, the HLB of the mixed surfactant is calculated as follows. The HLB (mixed) of the mixed surfactant is the phase arithmetic average of the HLB values ​​of the individual nonionic surfactants based on their blending ratios. Mixed HLB = Σ (HLBx × Wx) / ΣWx HLBx indicates the HLB value of nonionic surfactant X. Wx indicates the mass (g) of nonionic surfactant X having the value of HLBx.

[0027] The surfactants can be used alone or in combination of two or more. From the viewpoints of improving emulsion stability, improving spreadability upon application, and improving the feel upon use, the content is preferably 0.05 to 6 mass %, more preferably 0.1 to 5 mass %, even more preferably 0.3 to 4 mass %, and even more preferably 0.5 to 3.5 mass %, of the total composition.

[0028] When the cosmetic of the present invention is an emulsion composition, the water content is preferably 20 to 99% by mass, more preferably 35 to 98% by mass, of the total composition.

[0029] When the cosmetic of the present invention is formulated as an emulsion composition, it can further contain a polyhydric alcohol, which can improve spreadability upon application and improve the feel during use. The polyhydric alcohol of the present invention does not contain component (A) sucrose, but is a polyhydric alcohol other than component (A). The polyhydric alcohol is a compound having two or more hydroxyl groups in the molecule, and any polyhydric alcohol commonly used in cosmetic preparations may be used. Examples of dihydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, butylene glycol, and propanediol. Examples of trihydric alcohols include glycerin and trimethylolpropane. Examples of tetrahydric alcohols include diglycerin and erythritol. Examples of polyhydric alcohols having a valence of five or more include polyglycerins such as triglycerin; sugars other than sucrose and sugar alcohols such as glucose, maltose, maltose, xylitol, sorbitol, malbitol, trehalose, polyoxyethylene methyl glucoside, polyoxyethylene ethyl glucoside, and polyoxyethylene propylene glucoside.

[0030] The polyhydric alcohols can be used alone or in combination of two or more. From the viewpoints of improving spreadability upon application and improving the feeling in use, the content is preferably 0.5 to 50 mass %, more preferably 1 to 40 mass %, and even more preferably 2 to 30 mass % of the total composition.

[0031] The cosmetic preparation of the present invention may further contain a thickener, which can improve emulsion stability, spreadability upon application, and usability. The thickener increases the viscosity of the cosmetic preparation by swelling in the continuous phase, water or oil, and may be any thickener commonly used in topical skin preparations. Examples of thickeners include polysaccharides such as xanthan gum, carrageenan, and Tremella fuciformis polysaccharide; modified polysaccharides such as carboxymethylated glucan, hydroxypropylmethylcellulose, and ethylcellulose; and synthetic polymers such as carboxyvinyl polymers, acyl-modified carboxyvinyl polymers, and sodium polyacrylate.

[0032] The content of the thickener is preferably 0.001 to 1.5% by mass, more preferably 0.005 to 1.0% by mass, and even more preferably 0.01 to 0.7% by mass, of the total composition, from the viewpoints of improving emulsion stability, improving spreadability upon application, and improving the feel upon use.

[0033] The oil used in the cosmetic of the present invention is preferably an oil that is liquid at 25° C. Liquid means that it has fluidity and includes a paste state. Oils that are liquid at 25° C. include those commonly used in cosmetics, such as hydrocarbon oils, ester oils, ether oils, silicone oils, and higher fatty acids.

[0034] Examples of hydrocarbon oils include squalane, liquid paraffin, liquid isoparaffin, light liquid isoparaffin, heavy liquid isoparaffin, α-olefin oligomer, etc. The hydrocarbon oil preferably contains one or more selected from squalane and α-olefin oligomer, and more preferably contains squalane.

[0035] Examples of the ester oil include monoester oil, diester oil, triester oil, and tetraester oil. Examples of the monoester oil include monoesters of aliphatic or aromatic monocarboxylic or dicarboxylic acids having 2 to 24 carbon atoms, and specific examples thereof include cetyl 2-ethylhexanoate, cetyl octanoate, isononyl isononanoate, isotridecyl isononanoate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, myristyl myristate, 2-hexyldecyl myristate, isopropyl palmitate, octyl palmitate, and the like. Examples of monoester oils include ethyl ester, 2-hexyldecyl palmitate, butyl stearate, isocetyl stearate, isocetyl isostearate, decyl oleate, isodecyl benzoate, octyl methoxycinnamate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, 2-ethylhexyl succinate, 2-hexyldecyl adipate, alkyl benzoate (C12 to C15), ethylhexyl methoxycinnamate, jojoba oil, etc. The monoester oil preferably contains one or more selected from ethylhexyl methoxycinnamate and jojoba oil, and more preferably contains jojoba oil.

[0036] Examples of diester oils include diesters of dicarboxylic acids having 3 to 18 carbon atoms and difatty acid esters of polyhydric alcohols. Specific examples include propylene glycol dicaprylate, neopentyl glycol dicaprate, glycol distearate, propylene glycol diisostearate, glyceryl diisostearate, glyceryl monomyristate monoisostearate, glycerin di-2-heptylundecanoate, di-2-ethylhexyl succinate, diisopropyl sebacate, diisostearyl malate, ethylene glycol di-2-ethylhexanoate, diisobutyl adipate, di-2-heptylundecyl adipate, and di-2-ethylhexyl sebacate.

[0037] Examples of triester oils include tri-fatty acid esters of trivalent or higher polyhydric alcohols, specifically glycerin triisopalmitate, glycerin tri-2-heptylundecanoate, trimethylolpropane triethylhexanoate, trimethylolpropane trioctanoate, tri(caprylic / capric)glycerin, glycerin trioleate, glycerin tri-2-ethylhexanoate, glycerin triisostearate, and vegetable oils such as olive oil, macadamia nut oil, meadowfoam oil, castor oil, safflower oil, sunflower oil, avocado oil, canola oil, apricot kernel oil, rice germ oil, and rice bran oil. The triester oil preferably contains one or more vegetable oils, more preferably one or more selected from olive oil and macadamia nut oil, and even more preferably olive oil.

[0038] Examples of tetraester oils include tetra-fatty acid esters of tetrahydric or higher polyhydric alcohols, and specific examples thereof include pentaerythritol tetra(behenate / benzoate / ethylhexanoate), pentaerythritol tetraethylhexanoate, pentaerythritol tetraoctanoate, and pentaerythritol tetra-2-ethylhexanoate.

[0039] The ether oils include dialkyl ethers, specifically dihexyl ether, dicaprylyl ether, cetyl-1,3-dimethylbutyl ether, and the like.

[0040] Examples of silicone oils include volatile and non-volatile linear dimethylpolysiloxanes such as dimethylpolysiloxane (1 cs), dimethylpolysiloxane (1.5 cs), dimethylpolysiloxane (2 cs), dimethylpolysiloxane (6 cs), dimethylpolysiloxane (20 cs), and dimethylpolysiloxane (100 cs); branched siloxanes such as methyl trimethicone, tris(trimethylsilyl)methylsilane, and tetrakis(trimethylsilyl)silane; cyclic dimethylsiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; crosslinked methylpolysiloxanes, reticular methylpolysiloxanes, methylphenylpolysiloxanes such as methyl trimethicone and diphenylsiloxyphenyl trimethicone, and higher alcohol-modified organopolysiloxanes. The silicone oil preferably contains one or more selected from linear dimethylpolysiloxanes and methylphenylpolysiloxanes, more preferably one or more selected from nonvolatile linear dimethylpolysiloxanes and methylphenylpolysiloxanes, and even more preferably methylphenylpolysiloxanes.

[0041] Examples of higher fatty acids include oleic acid, isostearic acid, and undecylenic acid.

[0042] From the viewpoint of usability, the oil agent that is liquid at 25°C preferably contains one or more selected from hydrocarbon oils, ester oils, ether oils, and silicone oils, more preferably contains hydrocarbon oils, ester oils, and silicone oils, even more preferably contains one or more selected from hydrocarbon oils, monoester oils, triester oils, and silicone oils, still more preferably contains one or more selected from squalane, ethylhexyl methoxycinnamate, olive oil, macadamia nut oil, jojoba oil, and methylphenylpolysiloxane, and particularly preferably contains one or more selected from squalane, olive oil, jojoba oil, and methylphenylpolysiloxane.

[0043] The content of the oil agent that is liquid at 25°C is preferably 0.1 to 95% by mass, more preferably 0.5 to 80% by mass, and even more preferably 1 to 75% by mass of the total composition, from the viewpoints of improving emulsion stability, improving spreadability upon application, and improving the feel upon use.

[0044] The cosmetic of the present invention can be produced by a conventional method. For example, it can be produced by appropriately mixing the specified components, and can be produced by uniformly mixing and dispersing all components, regardless of the mixing order. In particular, it can be prepared by low-energy production using little mechanical force in an environment of 40°C or less.

[0045] The cosmetic of the present invention can be applied to cosmetics, medicated cosmetics that are quasi-drugs, etc., and is more preferably applied as a skin care cosmetic.

[0046] With respect to the above-described embodiments, the present invention further discloses the following compositions, etc.: <1> A cosmetic preparation containing (A) sucrose and (B) sodium chloride. <2> The cosmetic preparation according to <1>, in which the molar ratio (A / B) of component (A) to component (B) is 0.1 or more and 10 or less. <3> A cosmetic preparation containing (A) sucrose, (B) sodium chloride, and (C) serine. <4> The cosmetic preparation according to any one of <1> to <3>, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range surrounded by the following coordinates in a ternary phase diagram. - Molar ratio percentages of components (A) (X), (B) (Y), and (C) (Z) contained: (X, Y, Z) = (90, 10, 0), (10, 10, 80), (10, 90, 0) <5> The cosmetic preparation according to <4>, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range surrounded by the following coordinates in a ternary phase diagram: The molar ratio percentages of components (A) (X), (B) (Y), and (C) (Z) are (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), and (10, 80, 10). <6> The cosmetic preparation according to any one of <1> to <5>, in which the total content of components (A), (B), and (C) is 0.05% by mass or more and 20% by mass or less. <7> The cosmetic preparation according to any one of <1> to <5>, in which the total content of components (A), (B), and (C) is 0.5% by mass or more and 3% by mass or less. <8> The cosmetic preparation according to any one of <1> to <7>, further comprising one or more selected from a surfactant, water, a polyhydric alcohol, a thickener, and an oil. <9> A moisture-absorbing agent composition comprising (A) sucrose and (B) sodium chloride. <10> The moisture absorbent composition according to <9>, wherein the molar ratio (A / B) of component (A) to component (B) is 0.1 or more and 10 or less. <11> The moisture absorbent composition containing (A) sucrose, (B) sodium chloride, and (C) serine. <12> The moisture absorbent composition according to any one of <9> to <11>, wherein (A) sucrose, (B) sodium chloride, and (C) serine are contained within a range surrounded by the following coordinates in a ternary phase diagram:- Molar ratio percentages of component (A) (X), component (B) (Y), and component (C) (Z) (X, Y, Z) = (90, 10, 0), (10, 10, 80), (10, 90, 0) <13> The moisture-absorbent composition according to <12>, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range surrounded by the following coordinates in a ternary phase diagram: <14> The moisture-absorbent composition according to any one of <9> to <13>, wherein the total content of components (A), (B), and (C) is 0.16% by mass or more and 20% by mass or less. <15> The moisture-absorbent composition according to any one of <9> to <13>, wherein the total content of components (A), (B), and (C) is 0.7% by mass or more and 3% by mass or less. <16> The moisture-absorbent composition according to any one of <9> to <13>, wherein the total content of components (A), (B), and (C) is 0.16% by mass or more and 20% by mass or less. <17> The moisture-absorbent composition according to any one of <9> to <13>, wherein the total content of components (A), (B), and (C) is 0.7% by mass or more and 3% by mass or less.

[0047] The present invention will now be described in more detail with reference to examples, but the present invention is not limited to these examples.

[0048] Test Example 1 Sucrose, serine, and sodium chloride were weighed out in a molar ratio (percentage) as shown in Table 1 so that the total amount was 1000 μmol, and then uniformly mixed in a 2.0 mL microtube. Next, a beaker containing a saturated aqueous solution of sodium chloride was placed inside a sealed chamber and allowed to stand at 20°C, creating a 72% humidity environment. The microtube containing the mixture of sucrose, serine, and sodium chloride was allowed to stand in the 72% humidity environment for 3 days with the lid open, and then reweighed. The weight before standing was subtracted from the weight after standing, and the difference was taken as the water absorption. Furthermore, deliquescence was visually assessed based on the appearance of the sample after standing, as shown in Figure 1 (x: no deliquescence observed, ◯: deliquescence observed, ⊚: significant deliquescence observed). The results are shown in Table 1.

[0049]

[0050] Table 1 shows that, although sucrose and sodium chloride do not exhibit deliquescence alone under these conditions (72% RH), the combination of sucrose and sodium chloride significantly improves deliquescence and water absorption. It was also found that the combination of serine and sodium chloride, or the combination of serine and sucrose, did not improve deliquescence. Furthermore, the combination of serine with sucrose and sodium chloride tended to improve deliquescence and water absorption. When the data in Table 1 is plotted on a ternary phase diagram, as shown in Figure 2, it can be seen that excellent deliquescence and improved water absorption can be achieved within the range of the molar ratio percentages of components (A) (X), (B) (Y), and (C) (Z) enclosed by the following coordinates (X, Y, Z) = (90, 10, 0), (10, 10, 80), and (10, 90, 0) in the ternary phase diagram.

[0051] Test Example 2 Sucrose, serine, and sodium chloride were weighed out in the molar ratios (percentages) shown in Table 2 so that the total amount was 1000 μmol, and then uniformly mixed in a 2.0 mL microtube. Next, a saturated aqueous solution of potassium iodide was placed in a sealed chamber and allowed to stand at 35°C, creating a 67% humidity environment. The microtube containing the mixture of sucrose, serine, and sodium chloride was allowed to stand for 3 days with the lid open in the 67% humidity environment, and then the water absorption and deliquescence were confirmed. The water absorption and deliquescence were evaluated in the same manner as in Test Example 1. The results are shown in Table 2.

[0052]

[0053] Table 2 reveals that the combined use of sucrose, sodium chloride, and serine significantly improves deliquescence and water absorption under conditions of 67% RH. When the data in Table 2 is plotted on a ternary phase diagram, as shown in Figures 3 and 4, it can be seen that the molar percentages of components (A) (X), (B) (Y), and (C) (Z) are within the range of the following coordinates (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), and (10, 80, 10) in the ternary phase diagram, where the molar percentages are those of components (A) (X), (B), (Y), and (C), respectively, the deliquescence and water absorption are more excellently improved. Furthermore, the deliquescence and water absorption are even more excellently improved within the range of the coordinates (X, Y, Z) = (50, 40, 10), (50, 20, 30), (20, 20, 60), and (20, 70, 10).

[0054] Test Example 3: The effect of a composition (aqueous solution) containing sucrose, sodium chloride, and serine on the moisturizing state of the stratum corneum was measured using the stratum corneum moisture content as an index. Three subjects washed the inside of their forearms with a cleanser (Biore U Foaming Hand Soap, manufactured by Kao), and then allowed to acclimate for 10 minutes under an environment of 25°C temperature and 60% relative humidity. After acclimatization, the stratum corneum moisture content of the three subjects was measured using a Corneometer (Corneometer CM825, manufactured by Integral). Next, 7 μL each of (1) water, (2) 68 mM sucrose aqueous solution, or (3) a total amount of 68 mM sucrose + sodium chloride + serine aqueous solution (molar ratio 1:1:1) was uniformly applied to a 2 cm × 3 cm area, and the stratum corneum moisture content was measured again after 7 hours under an environment of 25°C temperature and 60% relative humidity. The stratum corneum moisture content 7 hours after application was subtracted from the stratum corneum moisture content before application of the sample, and the difference was defined as the delta stratum corneum moisture content. The results are shown in Figure 5. Figure 5 shows that the sucrose, sodium chloride, and serine combination group had a significantly higher stratum corneum moisture content after application than the water and sucrose alone groups, indicating an improved moisturizing state of the stratum corneum.

[0055] Test Example 4 Approximately 0.05 mL of the lotions having the compositions shown in Tables 3 and 4 were applied to the backs of the hands of three subjects, and the moisturizing effect (moisturizing feeling, lack of squeaky feeling) after application was evaluated. The composition of the lotions was recorded in terms of mass concentration and molar concentration, and the molar amount when adjusted to a total volume of 0.1 L. The scores of each subject were averaged to calculate the average score for the feeling of use. Evaluation of moisturizing feeling 4 points: Very moisturizing 3 points: Slightly moisturizing 2 points: Not very moisturizing 1 point: Not moisturizing Evaluation of lack of squeaky feeling: 4 points: No squeaky feeling 3 points: Slight squeaky feeling 2 points: Slight squeaky feeling 1 point: Squeaky feeling

[0056]

[0057]

[0058] As can be seen from Tables 3 and 4, the lotions containing sucrose and sodium chloride and the lotions containing sucrose, sodium chloride and serine left the skin feeling moisturized, without any dryness or stinging, and had good moisturizing effects.

[0059] Test Example 5: The effect of a composition (aqueous solution) containing sucrose, sodium chloride, and serine on the moisturizing state of the stratum corneum was measured using the moisture content of the stratum corneum as an index. The moisture content of the stratum corneum was measured according to the "Method for Evaluating Moisture Content of the Skin Stratum Corneum" in Japanese Patent No. 7642437, calculated from the peak of the infrared absorption spectrum of the tape-stripped stratum corneum. The specific test method is described below. Three subjects washed the inside of their forearms with a cleanser (Biore U Foaming Hand Soap, Kao), and then allowed to acclimate for 10 minutes in an environment at 25°C and 60% relative humidity. After acclimatization, adhesive tape (TF15-02, Azflon Tape, AS ONE) was applied, and stratum corneum samples were collected from the adhesive surface of the tape. Next, 10.5 μl of each of (1) water, (2) 60 mM sucrose aqueous solution, (3) a total of 60 mM sucrose + sodium chloride aqueous solution (molar ratio 4:3), or (4) a total of 60 mM sucrose + sodium chloride + serine aqueous solution (molar ratio 1:1:1) was uniformly applied to a 3 cm × 3 cm area. Stratum corneum samples were collected after 1 hour and 8 hours at 25°C and 60% relative humidity using the same method as above. The compositions of the water and aqueous solutions (lotions) used in the test are listed in Table 5. The infrared absorption spectra of the stratum corneum samples obtained were measured using the method described in Japanese Patent No. 764237 to calculate the stratum corneum moisture content. The stratum corneum moisture content after 1 hour and 8 hours was calculated, with the stratum corneum moisture content before application (0 hours) set to 1, and the results were compared between samples. The results are shown in Figure 6 and Table 6.

[0060]

[0061]

[0062] The three-ingredient lotion, which added serine to the stratum corneum, showed a better moisturizing effect than the two-ingredient lotion, sucrose and sodium chloride, because it increased the moisture content of the stratum corneum after 1 hour and 8 hours. It is also thought to affect the moist feeling even after a long time has passed since application.

[0063]

[0064]

[0065]

[0066]

[0067]

[0068]

[0069]

[0070] The lotions, emulsions, and creams in Tables 7 to 13 all left the skin feeling moisturized, without any dry or stinging sensation, and were preparations with good moisturizing effects.

Claims

1. A cosmetic preparation containing (A) sucrose and (B) sodium chloride.

2. The cosmetic composition according to claim 1, wherein the molar ratio (A / B) of component (A) to component (B) is 0.1 or more and 10 or less.

3. A cosmetic containing (A) sucrose, (B) sodium chloride, and (C) serine.

4. The cosmetic preparation according to any one of claims 1 to 3, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range enclosed by the following coordinates in a ternary phase diagram: - Molar ratio percentages of component (A) (X), component (B) (Y), and component (C) (Z): (X, Y, Z) = (90, 10, 0), (10, 10, 80), (10, 90, 0).

5. The cosmetic preparation according to claim 4, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range enclosed by the following coordinates in a ternary phase diagram: - Molar ratio percentages of component (A) (X), component (B) (Y), and component (C) (Z) (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), (10, 80, 10).

6. A moisture absorbent composition comprising (A) sucrose and (B) sodium chloride.

7. The moisture absorbent composition according to claim 6, wherein the molar ratio (A / B) of component (A) to component (B) is 0.1 or more and 10 or less.

8. A moisture absorbent composition comprising (A) sucrose, (B) sodium chloride, and (C) serine.

9. The moisture absorbent composition according to any one of claims 6 to 8, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range enclosed by the following coordinates in a ternary phase diagram: - Molar ratio percentages of component (A) (X), component (B) (Y), and component (C) (Z) (X, Y, Z) = (90, 10, 0), (10, 10, 80), (10, 90, 0).

10. The moisture absorbent composition according to claim 9, containing (A) sucrose, (B) sodium chloride, and (C) serine within the range enclosed by the following coordinates in a ternary phase diagram: - Molar ratio percentages of component (A) (X), component (B) (Y), and component (C) (Z) (X, Y, Z) = (70, 20, 10), (50, 20, 30), (50, 10, 40), (10, 10, 80), (10, 80, 10).

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