Dripping nozzle for preparing multilayer dripping pill, production system, and production method

Abstract

The present invention relates to the technical field of the preparation of multilayer dripping pills. Disclosed are a dripping nozzle for preparing a multilayer dripping pill, a production system, and a production method. The dripping nozzle comprises an inner-layer material conduit, a middle-layer material conduit, and an outer-layer material conduit. A middle-layer material delivery channel is provided between the middle-layer material conduit and the inner-layer material conduit, and an outer-layer material delivery channel is provided between the outer-layer material conduit and the middle-layer material conduit. The inner-layer material conduit is in communication with an inner-layer material delivery pipe, and the inner-layer material delivery pipe is arranged in an inner-layer constant-temperature liquid heat preservation chamber. The middle-layer material delivery channel is in communication with a middle-layer material delivery pipe, and the middle-layer material delivery pipe is arranged in a middle-layer constant-temperature liquid heat preservation chamber. The outer-layer material delivery channel is in communication with an outer-layer material delivery pipe, and the outer-layer material delivery pipe is arranged in an outer-layer constant-temperature liquid heat preservation chamber. The present invention can keep the temperatures of the materials at the respective layers different and constant, and enables synchronous and uniform discharge of the materials at the respective layers in a reasonable proportion at the outlet of the dripping nozzle, thereby producing a multilayer dripping pill with a better effect.

Description

Dropper, production system and production method for preparing multilayer drop pills TECHNICAL FIELD

[0001] The present application relates to the technical field of multilayer drop pill preparation, in particular to a dropper, production system and production method for preparing multilayer drop pills. BACKGROUND

[0002] At present, there are many studies on the physical and chemical embedding and slow-release of bioactive substances (probiotics, intestinal flora) at home and abroad, and most of them use single-layer or two-layer aqueous phase systems for embedding and slow-release. For example, embedding is carried out by using sodium alginate, chitosan and other polysaccharides, and also by using soybean protein, gelatin and other proteins; embedding is also carried out by using oil and fat substances such as propolis, shellac, hardened oil and fat, and animal and plant oil and fat; embedding is also carried out by using two or more substances such as polysaccharide compounding, protein compounding, polysaccharide-protein compounding, and lipid-protein compounding; in addition, hydrophilic substances such as polysaccharides and proteins are modified by hydrophobic modification, and the slow-release speed is controlled by controlling the degree of hydrophobic modification. Most of these technologies use hydrophilic systems to disperse bioactive substances (such as probiotics and intestinal flora), which has a great influence on the stability and activity of bioactive substances, greatly affects the effect and yield, and increases the cost; some technologies have a complex process and many procedures, and are difficult to industrialize; in addition, most of these hydrophilic systems use single-layer single-phase or double-layer double-phase aqueous dispersion systems, which cannot guarantee that the bioactive substances (such as probiotics) are not activated, thereby affecting their stability. In addition, since bioactive substances are generally sensitive to gastric acid, the above processes have limited protection for active substances.

[0003] Drop pills are a high-end dosage form in the field of pharmacy. Due to its special structure, it can endow the medicine with special performance. Drop pills are small pill-shaped preparations prepared by dropping a mixture of solid or liquid medicine and appropriate substances (generally referred to as matrix) into a non-miscible condensate liquid after being heated and melted, and then being shrunk and condensed. They are mainly for oral use. From the composition and preparation method of drop pills, they have the following characteristics: 1. The equipment is simple, the operation is convenient, labor protection is beneficial, the process cycle is short, and the production rate is high; 2. The process conditions are easy to control, the quality is stable, the dosage is accurate, the heating time is short, and the medicine that is easy to oxidize and volatile can increase its stability after being dissolved in the matrix; 3. The matrix can contain a large amount of liquid medicine, so the liquid medicine can be solidified, such as the oil content of ginger oil drop pills can reach 83.5%; 4. Drop pills prepared by solid dispersion technology have the characteristics of rapid absorption and high bioavailability, such as the effective dose of griseofulvin drop pills is 1 / 4 of 100 mesh fine powder and 1 / 2 of micro powder (particle size below 5 microns); 5. New dosage forms for otic and ophthalmic drugs are developed, and most of the preparations for the five sense organs are in liquid or semi-solid form, and the action time is not long-lasting. The preparation of drop pills can prolong the effect.

[0004] Dripping pills have the advantage of "three effects", which refers to fast-acting, high efficiency and long-acting. Dripping pills are mostly sublingual, and the drug is absorbed through the sublingual mucosa, enters the blood circulation, avoids the liver first-pass effect caused by swallowing and the degradation loss of the drug in the stomach, so that the drug can reach the target organ at high concentration, and quickly take effect. Generally, it takes 5-15 minutes to take effect, and at most not more than 30 minutes. Some also add a sustained-release agent to significantly prolong the half-life of the drug and achieve long-acting purposes. When needed, it can be taken orally.

[0005] Currently, there are mainly the following types of dripping pills:

[0006] Fast-acting and high-efficiency dripping pills: Dripping pills are prepared using solid dispersion technology. When the matrix dissolves, the drug in the body is released in the form of fine crystals, amorphous particles or molecules, so the dissolution, absorption, action and bioavailability are fast. A typical example of this type of product is fast-acting heart pain dripping pills.

[0007] Sustained-release and controlled-release dripping pills: Sustained release is to make the drug in the dripping pills slowly dissolve over a long period of time, and long-acting; controlled release is to make the drug in the dripping pills dissolve at a constant rate, and its effect can last for several days or more, such as chloramphenicol controlled-release eye pills.

[0008] Solution dripping pills: The lubricants and disintegrants used in tablets are mostly water-insoluble, so tablets cannot usually be used to prepare clear solutions. Dripping pills can be prepared with water-soluble bases, which can be disintegrated into clear solutions in water, such as washing betadine dripping pills, which can be used for water disinfection.

[0009] Suppository dripping pills: Dripping pills, like water-soluble suppositories, can use water-soluble bases such as polyethylene glycol, and when used in the cavity, they are dissolved by body fluids to produce effects. For example, fluroquinolone ear dripping pills and metronidazole dental dripping pills. Dripping pills can also be used for rectal administration and can be absorbed by the rectum to act directly on the whole body, with the characteristics of high bioavailability and fast action.

[0010] Hard capsule dripping pills: Different dissolution rates of dripping pills can be placed in hard capsules to form sustained-release small pill capsules with the desired dissolution rate, such as hard capsule dripping pills of bifendate.

[0011] Coated dripping pills: Like tablets and pills, they need to be coated with sugar or film, such as bifendate dripping pills.

[0012] Liposome dripping pills: Liposomes are suspensions, and polyethylene glycol can be used to prepare solid dosage forms. This is done by adding liposomes to molten polyethylene glycol 4000 under constant stirring to form a suspension, which is poured into a mold and cooled to form a solid.

[0013] Dry coated dripping pills: With dripping pills as the center, other drugs are pressed into the coating layer, combining the advantages of the two types of dosage forms, such as coughing clearing potassium chloride dry coated tablets for relieving cough and expectorating. The former is a dripping pill, and the latter is a coating layer.

[0014] The classical drop pills are not layered, and the drop pills are a uniform mixture from inside to outside. With the development of the preparation, there is a strong demand for the development of multi-layer drop pills (such as three-layer drop pills). The preparation process of these multi-layer drop pills, such as double-layer drop pills, is different from the soft capsules produced by the drop method, because the content of the soft capsule is liquid, while the internal components of the multi-layer drop pills, such as three-layer drop pills, are basically solid at room temperature. Therefore, the soft capsule production equipment / process cannot be applied to the multi-layer drop pills (such as three-layer drop pills).

[0015] Therefore, there is an urgent need in the art for a device capable of droping multi-layer drop pills, especially three-layer drop pills, and / or parts thereof, and such a device can ensure the production effect of the drop pills.

[0016] SUMMARY

[0017] The purpose of the present application is to provide a drop head, a production system and a production method for preparing multi-layer drop pills, to solve the problems existing in the prior art, to keep the temperature of each layer of material different and constant during the drop production process, to make the middle layer and the outer layer of material flow out synchronously and uniformly at the outlet of the drop head, to make the middle layer and the outer layer of material completely wrap the inner layer of material, to stably control the temperature of the cooling liquid and the flow in the cooling liquid circulation pipeline, to provide stable environmental conditions for the pill forming process, to smoothly dry and deoxygenate the drop pills in a short time, to keep the roundness of the drop pills and the activity of the internal microorganisms or active ingredients, and to produce multi-layer drop pills with better effects.

[0018] To achieve the above-mentioned purpose, the present application provides the following scheme:

[0019] In an embodiment, a drop head for preparing multi-layer drop pills is introduced, which comprises an inner layer material guide pipe, a middle layer material guide pipe and an outer layer material guide pipe which are coaxially arranged from inside to outside.

[0020] The middle layer material guide pipe and the inner layer material guide pipe form an annular middle layer material conveying channel, and the outer layer material guide pipe and the middle layer material guide pipe form an annular outer layer material conveying channel.

[0021] The inlet end of the inner layer material guide pipe is in communication with an inner layer material conveying pipe, and the inner layer material conveying pipe is arranged in an inner layer constant temperature liquid heat preservation cavity.

[0022] The inlet end of the middle layer material conveying channel is in communication with a middle layer material conveying pipe, and the middle layer material conveying pipe is arranged in a middle layer constant temperature liquid heat preservation cavity.

[0023] The inlet end of the outer layer material conveying channel is in communication with an outer layer material conveying pipe, and the outer layer material conveying pipe is arranged in an outer layer constant temperature liquid heat preservation cavity.

[0024] In an embodiment, the wall thickness of the outer layer material conduit is 1.0-6.0 mm, the wall thickness of the middle layer material conduit is 0.1-1.2 mm, the wall thickness of the inner layer material conduit is 0.1-1.2 mm, the inner radius r of the inner layer material conduit is 0.25-5.0 mm, the gap h1 between the middle layer material conduit and the inner layer material conduit is 0.2-2.0 mm, the gap h2 between the outer layer material conduit and the middle layer material conduit is 0.2-2.0 mm, and the ratio of h2, h1 and r is 1:(0.5-2): (1-4).

[0025] In an embodiment, a chamfer is arranged in the outlet end of the outer layer material conduit.

[0026] In another embodiment, a multi-layered dripping pill production system is introduced, which comprises a material supply device, a dripping head, a circulating cooling device, a pill-liquid separation device and a drying and deoiling machine;

[0027] The dripping head is the dripping head for preparing multi-layered dripping pills as described above;

[0028] The material supply device comprises an inner layer material supply device, a middle layer material supply device and an outer layer material supply device;

[0029] The discharge port of the inner layer material supply device is communicated with the inner layer material conveying pipe, for conveying the inner layer material to the inner layer material conduit through the inner layer material conveying pipe;

[0030] The discharge port of the middle layer material supply device is communicated with the middle layer material conveying pipe, for conveying the middle layer material to the middle layer material conveying channel through the middle layer material conveying pipe;

[0031] The discharge port of the outer layer material supply device is communicated with the outer layer material conveying pipe, for conveying the outer layer material to the outer layer material conveying channel through the outer layer material conveying pipe;

[0032] The outlet end of the dripping head is communicated with the circulating cooling device, and the material dripping from the dripping head is solidified and formed into three-layered dripping pills in the cooling liquid of the circulating cooling device, and the dripping pills are conveyed with the circulating cooling liquid to the pill-liquid separation device for separation of the dripping pills and the cooling liquid;

[0033] The drying and deoiling machine is used for drying and deoiling treatment of the separated dripping pills.

[0034] In an embodiment, the inner layer material supply device is externally provided with an inner layer material constant temperature isolation sleeve, which is communicated with the inner layer constant temperature liquid heat preservation cavity;

[0035] The middle layer material supply device is externally provided with a middle layer material constant temperature jacket, which is in communication with the middle layer constant temperature liquid heat preservation cavity.

[0036] The outer layer material supply device is externally provided with an outer layer material constant temperature jacket, which is in communication with the outer layer constant temperature liquid heat preservation cavity.

[0037] In an embodiment, the drying and deoiling machine comprises a sealed box body and a drying rotating cage assembly, the top of the sealed box body is provided with an openable sealing cover, one side of the sealed box body is provided with an air inlet for introducing drying air, and the other side is provided with an air outlet, the drying rotating cage assembly is arranged in the sealed box body, the drying rotating cage assembly comprises a drying rotating cage, a rotating cage driving motor, a wind collecting box and a fan, the drying rotating cage is rotationally connected in the sealed box body and is driven to rotate by the rotating cage driving motor, the wind collecting box is arranged below the drying rotating cage and is connected with the fan, the wind collecting box is used for guiding the air volume generated by the fan into the drying rotating cage, and deoiling cloth is placed in the drying rotating cage for deoiling treatment of the dripping pills.

[0038] In an embodiment, the inner layer material supply device comprises an inner layer material tank, the inner layer material tank is fixedly installed in the inner layer material constant temperature jacket, the inner layer material constant temperature jacket is arranged on an inner layer material weighing sensor, and the bottom discharge port of the inner layer material tank is connected with the inner layer material conveying pipe, the inner layer material conveying pipe is provided with an inner layer material tank bottom valve and an inner layer material pump.

[0039] The middle layer material supply device comprises a middle layer material tank, the middle layer material tank is fixedly installed in the middle layer material constant temperature jacket, the middle layer material constant temperature jacket is arranged on a middle layer material weighing sensor, the bottom discharge port of the middle layer material tank is connected with the middle layer material conveying pipe, and the middle layer material conveying pipe is provided with a middle layer material tank bottom valve and a middle layer material pump.

[0040] The outer layer material supply device comprises an outer layer material tank, the outer layer material tank is fixedly installed in the outer layer material constant temperature jacket, the bottom discharge port of the outer layer material tank is connected with the outer layer material conveying pipe, and the outer layer material conveying pipe is provided with an outer layer material tank bottom valve and an outer layer material pump.

[0041] The inner layer material tank and the middle layer material tank are both provided with a homogenizing stirring paddle, the homogenizing stirring paddle is externally provided with a homogenizing stirring jacket, the outer layer material tank is provided with a stirring paddle, and the homogenizing stirring paddle and the stirring paddle are respectively driven to rotate by driving motors.

[0042] In an embodiment, the homogenizing stirring paddle comprises a driving rod, a stator and a rotor, one end of the driving rod is connected with the output shaft of the driving motor, the other end of the driving rod is connected with the rotor, and the stator is sleeved outside the rotor.

[0043] In an embodiment, the pellet-liquid separation device comprises a pellet-liquid separation filter screen and a cooling liquid recovery tray arranged below the pellet-liquid separation filter screen, the circulating cooling device comprises a cooling box, a cooling liquid circulating pipeline, a cooling liquid refrigeration storage box and a refrigeration stirring device, the outlet end of the drop head is connected with the cooling box, one end of the cooling liquid circulating pipeline is connected with the cooling box, and the other end of the cooling liquid circulating pipeline is connected with the pellet-liquid separation filter screen, the cooling liquid outlet of the cooling liquid recovery tray is connected with the cooling liquid refrigeration storage box, the refrigeration stirring device is connected with the cooling liquid refrigeration storage box, and the refrigeration stirring device is used for refrigerating and stirring the cooling liquid in the cooling liquid refrigeration storage box, the cooling liquid refrigeration storage box is connected with the cooling box through a cooling liquid supply pipeline, and a cooling liquid circulating pump is arranged on the cooling liquid supply pipeline.

[0044] In an embodiment, the refrigeration stirring device comprises a cooling liquid stirring device, a cooling coil and a refrigeration machine, the cooling coil is arranged in the cooling liquid refrigeration storage box, and two ports of the cooling coil are connected with the refrigeration machine; the cooling liquid stirring device comprises a cooling liquid stirring paddle, a driving connecting rod and a stirring driving motor, the output shaft of the stirring driving motor is connected with one end of the driving connecting rod, the other end of the driving connecting rod is connected with the cooling liquid stirring paddle, and the cooling liquid stirring paddle is arranged in the internal space formed by the cooling coil.

[0045] In another embodiment, a multi-layered drop pill production method is introduced, which is based on the multi-layered drop pill production system described above, and comprises the following steps:

[0046] The temperature of the outer layer material is controlled by the outer layer material constant temperature jacket and the outer layer constant temperature liquid in the outer layer constant temperature liquid cavity, the temperature of the middle layer material is controlled by the middle layer material constant temperature jacket and the middle layer constant temperature liquid in the middle layer constant temperature liquid cavity, and the temperature of the inner layer material is controlled by the inner layer material constant temperature jacket and the inner layer constant temperature liquid in the inner layer constant temperature liquid cavity.

[0047] The outer layer material is put into the outer layer material tank, the middle layer material is put into the middle layer material tank, and the inner layer material is put into the inner layer material tank.

[0048] The outer layer material in the outer layer material tank, the middle layer material in the middle layer material tank and the inner layer material in the inner layer material tank are transported to the drop head, and the materials of each layer flow into the cooling liquid at the same time through the outlet end of the drop head.

[0049] The outer layer material, the middle layer material and the inner layer material are condensed and shaped in the cooling liquid to obtain three-layer drop pills, and then the drop pills and the cooling liquid are separated through the pill liquid separation device;

[0050] The separated drop pills are dried and deoiled through the drying and deoiling machine.

[0051] The present application has the following technical effects relative to the prior art:

[0052] The drop head for preparing the multi-layer drop pills can control the temperature of the inner layer material, the middle layer material and the outer layer material to be different and keep the temperature of each layer of material constant through the constant temperature control of the constant temperature liquid in the inner layer constant temperature liquid heat preservation cavity, the middle layer constant temperature liquid heat preservation cavity and the outer layer constant temperature liquid heat preservation cavity, thereby improving the stability of drop pill forming and producing drop pills with better effects.

[0053] The multi-layer drop pill production system and the production method can control the temperature of the inner layer material, the middle layer material and the outer layer material to be different and keep the temperature of each layer of material constant through the constant temperature control of the constant temperature liquid in the inner layer constant temperature liquid heat preservation cavity, the middle layer constant temperature liquid heat preservation cavity and the outer layer constant temperature liquid heat preservation cavity, thereby improving the stability of drop pill forming, and the circulating cooling device can stabilize the temperature of the cooling liquid during drop pill forming, and the drop pills after cooling and shaping are separated from the cooling liquid through the pill liquid separation device and then dried and deoiled through the drying and deoiling machine, thereby producing drop pills with better effects. BRIEF DESCRIPTION OF DRAWINGS

[0054] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative effort on the basis of these drawings.

[0055] Fig. 1 is a structural schematic diagram of a Huanglong drop pill;

[0056] Fig. 2 is a sectional view of the Huanglong drop pill;

[0057] Fig. 3 is a structural schematic diagram of a drop head according to one or more embodiments;

[0058] Fig. 4 is a structural schematic diagram of three-layer material pipes in the drop head according to one or more embodiments;

[0059] Fig. 5 is a partial enlarged schematic diagram of part A in Fig. 4;

[0060] Figure 6 is a schematic diagram of a cross-section of a three-layer material conduit in a drop head according to one or more embodiments;

[0061] Figure 7 is a schematic diagram of the working principle of a multi-layer drop pill production system according to one or more embodiments;

[0062] Figure 8 is a schematic diagram of the structure of a homogenizing stirring device according to one or more embodiments;

[0063] Figure 9 is a schematic diagram of the exploded structure of a homogenizing stirring device according to one or more embodiments;

[0064] Figure 10 is a schematic diagram of the structure of a refrigeration stirring device according to one or more embodiments;

[0065] Figure 11 is a schematic diagram of the working principle of a dry deoiling machine according to one or more embodiments;

[0066] Figure 12 is a schematic diagram of the structure of a dry deoiling machine according to one or more embodiments;

[0067] Figure 13 is a schematic diagram of the structure of a dry rotating cage assembly according to one or more embodiments;

[0068] Figure 14 is a schematic diagram of the structure of a sealing box according to one or more embodiments.

[0069] In the figure: 100-dropper, 200-multilayered drop pill production system, 300-Huanglong drop pill, 301-inner layer, 302-middle layer, 303-outer layer, 1-inner layer material conduit, 2-middle layer material conduit, 3-outer layer material conduit, 4-middle layer material conveying channel, 5-outer layer material conveying channel, 6-inner layer material conveying pipe, 7-inner layer constant temperature liquid heat preservation cavity, 8-middle layer material conveying pipe, 9-middle layer constant temperature liquid heat preservation cavity, 10-outer layer material conveying pipe, 11-outer layer constant temperature liquid heat preservation cavity, 12-chamfer, 13-material supply device, 131-inner layer material supply device, 1310-inner layer material tank, 132-middle layer material supply device, 1320-middle layer material tank, 133-outer layer material supply device, 1330-outer layer material tank, 14-circulating cooling device, 141-cooling box, 142-cooling liquid circulating pipeline, 143-cooling liquid refrigeration storage box, 144-refrigeration stirring device, 1440-cooling liquid stirring device, 14401-cooling liquid stirring paddle, 14402-driving connecting rod, 14403-stirring driving motor, 1441-cooling coil pipe, 1442-refrigeration machine, 145-cooling liquid supply pipeline, 146-cooling liquid circulating pump, 15-pill liquid separation device, 151-pill liquid separation filter screen, 152-cooling liquid recovery tray, 16-inner layer material constant temperature isolation sleeve, 17-middle layer material constant temperature isolation sleeve, 18-outer layer material constant temperature isolation sleeve, 19-drop pill, 20-drying and deoiling machine, 210-sealing box body, 211-sealing cover, 212-air inlet, 213-air outlet, 220-drying rotating cage assembly, 221-drying rotating cage, 222-rotating cage driving motor, 223-air collecting box, 224-fan, 225-rack, 21-inner layer material weighing sensor, 22-inner layer material tank bottom valve, 23-inner layer material pump, 24-middle layer material weighing sensor, 25-middle layer material tank bottom valve, 26-middle layer material pump, 27-outer layer material tank bottom valve, 28-outer layer material pump, 29-homogenizing stirring paddle, 291-driving rod, 292-stator, 293-rotor, 30-driving motor, 31-homogenizing stirring sleeve, 32-stirring paddle. DETAILED DESCRIPTION

[0070] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0071] The application aims to provide a dripping head, a production system and a production method for preparing multilayer dripping pills, so as to solve the problems in the prior art, keep the temperature of materials in the dripping production process constant, and produce dripping pills with better effects.

[0072] In order to make the above-mentioned purposes, features and advantages of the application more obvious and easy to understand, the application will be further described in detail below in combination with the drawings and specific embodiments.

[0073] Embodiment one

[0074] As shown in FIGS. 3-6, the present embodiment provides a dripping head 100 for preparing multilayer dripping pills, which can prepare the yellow dragon dripping pill 300 shown in FIGS. 1-2. The yellow dragon dripping pill 300 has a three-layer structure, the inner layer 301 is a fecal bacteria raw material, the middle layer 302 is a protective layer, and the outer layer 303 is a film with the characteristics of resisting gastric acid and bile, which can deliver the live bacteria in the fecal bacteria raw material to the intestinal tract for release, achieving the effect of fecal bacteria transplantation.

[0075] In some embodiments, the dripping head 100 for preparing multilayer dripping pills includes an inner layer material conduit 1, a middle layer material conduit 2 and an outer layer material conduit 3 which are coaxially arranged from inside to outside.

[0076] The inlet end of the inner layer material conduit 1 is higher than the inlet ends of the middle layer material conduit 2 and the outer layer material conduit 3, and the inlet end of the middle layer material conduit 2 is higher than the inlet end of the outer layer material conduit 3.

[0077] The middle layer material conduit 2 and the inner layer material conduit 1 form an annular middle layer material conveying channel 4, and the outer layer material conduit 3 and the middle layer material conduit 2 form an annular outer layer material conveying channel 5.

[0078] The inlet end of the inner layer material conduit 1 is in communication with an inner layer material conveying pipe 6, and the inner layer material conveying pipe 6 is arranged in an inner layer constant temperature liquid heat preservation cavity 7.

[0079] The inlet end of the middle layer material conveying channel 4 is in communication with a middle layer material conveying pipe 8, and the middle layer material conveying pipe 8 is arranged in a middle layer constant temperature liquid heat preservation cavity 9.

[0080] The inlet end of the outer layer material conveying channel 5 is in communication with an outer layer material conveying pipe 10, and the outer layer material conveying pipe 10 is arranged in an outer layer constant temperature liquid heat preservation cavity 11.

[0081] By setting the inner layer constant temperature liquid heat preservation cavity 7, the middle layer constant temperature liquid heat preservation cavity 9 and the outer layer constant temperature liquid heat preservation cavity 11, each cavity can be filled with heat preservation liquid, when preparing multi-layer drop pills, by constant temperature control of the heat preservation liquid in the inner layer constant temperature liquid heat preservation cavity 7, the middle layer constant temperature liquid heat preservation cavity 9 and the outer layer constant temperature liquid heat preservation cavity 11 respectively, the temperature of the inner layer material, the middle layer material and the outer layer material can be different, and the temperature of each layer of material remains constant, which improves the stability of drop pill forming, thereby producing drop pills with better effect.

[0082] In some embodiments, the wall thickness of the outer layer material conduit 3 is 1.0-6.0mm, the wall thickness of the middle layer material conduit 2 is 0.1-1.2mm, the wall thickness of the inner layer material conduit 1 is 0.1-1.2mm, the inner radius r of the inner layer material conduit 1 is 0.25-5.0mm, the gap h1 between the middle layer material conduit 2 and the inner layer material conduit 1 is 0.2-2.0mm, the gap h2 between the outer layer material conduit 3 and the middle layer material conduit 2 is 0.2-2.0mm, and the ratio of h2, h1 and r is 1:(0.5-2):(1-4).

[0083] In some embodiments, the wall thickness of the outer layer material conduit 3 is 2mm, the wall thickness of the middle layer material conduit 2 is 0.4mm, the wall thickness of the inner layer material conduit 1 is 0.4mm, the inner radius r of the inner layer material conduit 1 is 1.2mm, the gap h1 between the middle layer material conduit 2 and the inner layer material conduit 1 is 0.9mm, the gap h2 between the outer layer material conduit 3 and the middle layer material conduit 2 is 0.6mm, and the ratio of h2, h1 and r is 1:1.5:2.

[0084] The size of the drop head mainly refers to the inner radius of the outer layer material conduit 3, which will affect the particle size of the drop pills. Generally speaking, the larger the drop head, the larger the particle size of the produced drop pills. Similarly, the size of the gap (h1 and h2) affects the thickness of the current layer. In order to produce reasonable drop pills, it is generally necessary to set appropriate gaps between each layer. In actual production, the values of each parameter of the drop head can be set according to the required specifications of the drop pills to be prepared.

[0085] In some embodiments, a chamfer 12 is arranged on the inner side of the outlet end of the outer layer material conduit 3. By arranging the chamfer 12, the size of the outlet end of the outer layer material conveying channel 5 can be increased, so that the material can flow more smoothly into the cooling liquid, avoiding the accumulation of material at the outlet end due to part processing burrs or material adhesion, reducing the resistance of the material flowing out into the cooling liquid, avoiding that a certain point at the outlet of the outer layer material conveying channel 5 is blocked or the gap is narrowed, affecting the wrapping effect of the outer layer material when forming pills, improving the uniformity of material distribution, thereby improving the forming effect of drop pills.

[0086] Example two

[0087] As shown in FIGS. 7-14, the present embodiment provides a multi-layered drop pill production system 200, which comprises a material supply device 13, the drop head 100 for preparing multi-layered drop pills as described in embodiment one, a circulating cooling device 14, a pill-liquid separation device 15, and a drying and deoiling machine 20;

[0088] The material supply device 13 comprises an inner layer material supply device 131, a middle layer material supply device 132, and an outer layer material supply device 133;

[0089] The discharge port of the inner layer material supply device 131 is in communication with the inner layer material delivery pipe 6, for delivering the inner layer material to the inner layer material guide pipe 1 through the inner layer material delivery pipe 6;

[0090] The discharge port of the middle layer material supply device 132 is in communication with the middle layer material delivery pipe 8, for delivering the middle layer material to the middle layer material delivery channel 4 through the middle layer material delivery pipe 8;

[0091] The discharge port of the outer layer material supply device 133 is in communication with the outer layer material delivery pipe 10, for delivering the outer layer material to the outer layer material delivery channel 5 through the outer layer material delivery pipe 10;

[0092] The outlet end of the drop head 100 leads to the circulating cooling device 14, and the material dropped from the drop head 100 is solidified and shaped into three-layered drop pills 19 in the cooling liquid of the circulating cooling device 14, and the drop pills 19 are delivered with the circulating cooling liquid to the pill-liquid separation device 15 for separation of the drop pills and the cooling liquid;

[0093] The drying and deoiling machine 20 is used for drying and deoiling treatment of the separated drop pills 19.

[0094] In some embodiments, the inner layer material supply device 131 is externally provided with an inner layer material constant temperature jacket 16, which is in communication with the inner layer constant temperature liquid heat preservation cavity 7;

[0095] The middle layer material supply device 132 is externally provided with a middle layer material constant temperature jacket 17, which is in communication with the middle layer constant temperature liquid heat preservation cavity 9;

[0096] The outer layer material supply device 133 is externally provided with an outer layer material constant temperature jacket 18, which is in communication with the outer layer constant temperature liquid heat preservation cavity 11.

[0097] In the production process, the temperature of the inner layer material, the middle layer material and the outer layer material can be different by controlling the temperature of the inner layer material constant temperature jacket 16 and the inner layer constant temperature liquid heat preservation cavity 7, the middle layer material constant temperature jacket 17 and the middle layer constant temperature liquid heat preservation cavity 9, and the outer layer material constant temperature jacket 18 and the outer layer constant temperature liquid heat preservation cavity 11, and the temperature of each layer of material remains constant, which improves the stability of the drop pill forming, and the circulating cooling device can stabilize the cooling liquid temperature during drop pill forming, and the drop pill 19 after cooling and shaping is separated from the cooling liquid by the pill liquid separation device 15, and the separated cooling liquid is recycled in the circulating cooling device, and the separated drop pill 19 is dried and deoiled by the drying and deoiling machine, so as to produce a drop pill 19 with better effect.

[0098] In some embodiments, the drying and deoiling machine 20 includes a sealed box body 210 and a drying rotating cage assembly 220. The top of the sealed box body 210 is provided with an openable sealing cover 211 to facilitate internal operation. One side of the sealed box body 210 is provided with an air inlet 212, and three sets of air inlets 212 can be selected to introduce dry air (humidity less than 2%). The other side of the sealed box body 210 opposite to the air inlet 212 is provided with an air outlet 213 for discharging humid air during gas replacement. The valve of the air outlet 213 is controlled by a pneumatic cylinder push rod, which can be opened and closed. The drying rotating cage assembly 220 is arranged in the sealed box body 210. The drying rotating cage assembly 220 includes a drying rotating cage 221, a rotating cage driving motor 222, a wind collecting box 223 and a fan 224. The drying rotating cage 221 is rotationally connected in the sealed box body 210 and is driven to rotate by the rotating cage driving motor 222. The wind collecting box 223 is arranged below the drying rotating cage 221 and is connected with the fan 224. The wind collecting box 223 is used to guide the air volume generated by the fan 224 into the drying rotating cage 221. The drying rotating cage 221 is placed with deoiling cloth for deoiling the drop pill 19.

[0099] The outer layer of the drop pill 19 (such as Huanglong drop pill) uses a water phase material, which contains moisture when it is just dropped, and the surface is sticky with cooling liquid oil (i.e. oily cooling liquid), so the moisture and the surface cooling liquid oil must be removed using a drying machine. The drying and deoiling machine 20 provided in this embodiment introduces dry air through the air inlet 212 and discharges the humid air inside from the air outlet 213, and continuously replaces the dry air, which can reduce the relative humidity inside the sealed box body 210 to 5%. The drying rotating cage 221 inside the sealed box body 210 is a cylindrical structure full of ventilation holes, the diameter of the ventilation holes is smaller than the particle size of the drop pill 19, and the drying rotating cage 221 is provided with a door plate, through which the drop pill 19 and the deoiling cloth can be placed inside the drying rotating cage 221. A fan 224 is arranged outside the drying rotating cage 221, the outlet of the fan 224 is connected with a wind collecting box 223, the air volume is guided to the drying rotating cage 221 through the wind collecting box 223 (or a deflector, a wind guide pipe, etc.), a rack 225 is fixed in the sealed box body 210, the rotating cage driving motor 222, the drying rotating cage 221, the wind collecting box 223 and the fan 224 are all mounted on the rack 225, and the drop pill 19 and the deoiling cloth are put into the drying rotating cage 221 together. During the rotation of the drying rotating cage 221, the drop pill 19 and the deoiling cloth inside keep rolling and are blown by the wind at the same time, the moisture on the surface of the drop pill 19 is gradually evaporated, the deoiling cloth contacts the drop pill 19 during the rolling process, and gradually absorbs the cooling liquid oil on the surface of the drop pill 19, so that the drying and deoiling effects are realized. The drying and deoiling machine 20 provided in this embodiment creates a low humidity environment by arranging the closed sealed box body 210 and introducing dry air, which can improve the drying speed and drying effect.

[0100] The following is a comparative experiment of the drying of the drop pill 19 by the drying and deoiling machine 20 in this embodiment with and without the sealed box body 210.

[0101] As shown in Table 1, three ordinary drying processes of the drying and deoiling machine 20 without the sealed box body 210. The drop pill 19 to be dried is put into the drying rotating cage 221, the rotating cage driving motor 222 is started, the drying rotating cage 221 rotates at a speed of 5-30 RPM, the fan 224 is started, the air in the environment is introduced into the drying rotating cage 221 through the wind collecting box 223, and the drop pill 19 is dried, and the three ordinary processes last for 240 minutes, 360 minutes and 480 minutes respectively.

[0102] Table 1 Ordinary drying process (without sealed box body)

[0103] As shown in Table 2, is the drying improved process 1 of the drying and deoiling machine 20 with the sealed box 210. The drop pills 19 to be dried are put into the drying rotating cage 221, the fan 224 is turned on, the rotating cage driving motor 222 is turned on, and the rotating cage driving motor 222 drives the drying rotating cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 50-60% (i.e. when the humidity is higher than 60%, dry air is introduced, and when the humidity is lower than 50%, the introduction of dry air is stopped), which lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is controlled at 40-50% (i.e. when the humidity is higher than 50%, dry air is introduced, and when the humidity is lower than 40%, the introduction of dry air is stopped), which lasts for 30 minutes. In this way, the drying process in each stage is carried out in turn until the time of each stage is completed. In each stage, the temperature in the sealed box 210 is controlled so as to keep the temperature in the sealed box 210 at 22-26°C, and the temperature control relies on the small refrigerating machine and the PTC heating unit for cooling and heating.

[0104] Table 2 Drying improved process 1 (with sealed box)

[0105] As shown in Table 3, is the drying improved process 2 of the drying and deoiling machine 20 with the sealed box 210. The drop pills 19 to be dried are put into the drying rotating cage 221, the fan 224 is turned on, the rotating cage driving motor 222 is turned on, and the rotating cage driving motor 222 drives the drying rotating cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 40-50% (i.e. when the humidity is higher than 50%, dry air is introduced, and when the humidity is lower than 40%, the introduction of dry air is stopped), which lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is controlled at 30-40% (i.e. when the humidity is higher than 40%, dry air is introduced, and when the humidity is lower than 30%, the introduction of dry air is stopped), which lasts for 30 minutes. In this way, the drying process in each stage is carried out in turn until the time of each stage is completed. In each stage, the temperature in the sealed box 210 is controlled so as to keep the temperature in the sealed box 210 at 22-26°C.

[0106] Table 3 Drying improved process 2 (with sealed box)

[0107] As shown in Table 4, the drying improved process 3 of the dry oil-removing machine 20 with the sealed box 210. The drop pills 19 to be dried are put into the drying rotating cage 221, the fan 224 is turned on, the rotating cage driving motor 222 is turned on, and the rotating cage driving motor 222 drives the drying rotating cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 40-50% (i.e. when the humidity is higher than 50%, dry air is supplied, and when the humidity is lower than 40%, the supply of dry air is stopped), which lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is set to be controlled at 25-35% (i.e. when the humidity is higher than 35%, dry air is supplied, and when the humidity is lower than 25%, the supply of dry air is stopped), which lasts for 60 minutes. The drying process of each stage is sequentially carried out until the time of each stage is completed. In each stage, the temperature in the sealed box 210 is controlled so as to keep the temperature in the sealed box 210 at 22-26℃.

[0108] Table 4 Drying improved process 3 (with sealed box)

[0109] As shown in Table 5, the effect comparison of the ordinary drying process (without sealed box) and the drying improved process (with sealed box).

[0110] Table 5 Drying effect comparison of ordinary process and improved process

[0111] According to the effect comparison in Table 5, it can be found that after the sealed box 210 is added, the drying time is obviously shortened, and the moisture content and water activity are obviously reduced. In the same drying time (the total drying time of the ordinary process 1 and the improved process 3 is the same), the moisture content of the improved process 3 is reduced by 4.25% than that of the ordinary process 1, and the water activity is reduced by 0.429Aw, which shows good effect.

[0112] In some embodiments, the inner layer material supply device 131 includes an inner layer material tank 1310, which is fixedly installed in the inner layer material constant temperature sleeve 16, the inner layer material constant temperature sleeve 16 is placed on the inner layer material weighing sensor 21, and the bottom discharge port of the inner layer material tank 1310 is connected to the inner layer material conveying pipe 6, which is provided with an inner layer material tank bottom valve 22 and an inner layer material pump 23;

[0113] The middle layer material supply device 132 includes a middle layer material tank 1320, which is fixedly installed in the middle layer material constant temperature sleeve 17, the middle layer material constant temperature sleeve 17 is placed on the middle layer material weighing sensor 24, and the bottom discharge port of the middle layer material tank 1320 is connected to the middle layer material conveying pipe 8, which is provided with a middle layer material tank bottom valve 25 and a middle layer material pump 26;

[0114] The outer layer material supply device 133 comprises an outer layer material tank 1330 fixedly installed in the outer layer material constant temperature jacket 18, and a bottom discharge port of the outer layer material tank 1330 is connected with the outer layer material conveying pipe 10, and the outer layer material conveying pipe 10 is provided with an outer layer material tank bottom valve 27 and an outer layer material pump 28; wherein the rotation speed of the inner layer material pump 23 is in a positive proportional relationship with the feeding speed of the inner layer material, the rotation speed of the middle layer material pump 26 is in a positive proportional relationship with the feeding speed of the middle layer material, and the rotation speed of the outer layer material pump 28 is in a positive proportional relationship with the feeding speed of the outer layer material.

[0115] The inner layer material tank 1310 and the middle layer material tank 1320 are both provided with a homogenizing stirring paddle 29, and the homogenizing stirring paddle 29 is provided with a homogenizing stirring sleeve 31 outside, and the outer layer material tank 1330 is provided with a stirring paddle 32, and the homogenizing stirring paddle 29 and the stirring paddle 32 are respectively driven to rotate by a driving motor 30.

[0116] In the dripping production process, as the inner layer material is continuously conveyed to the dripping head 100 by the inner layer material pump 23, and the middle layer material is continuously conveyed to the dripping head 100 by the middle layer material pump 26, the weight of the materials in the inner layer material tank 1310 and the middle layer material tank 1320 is reduced, which is detected by the inner layer material weighing sensor 21 and the middle layer material weighing sensor 24 respectively, and the controller starts to control the corresponding driving motor 30 to synchronously reduce the rotation speed, so that the homogenization of the materials can be better maintained, and the uniformity of the active ingredients and the particle size of the dripping pills are significantly improved.

[0117] In some embodiments, the homogenizing stirring paddle 29 comprises a driving rod 291, a stator 292 and a rotor 293, one end of the driving rod 291 is connected with the output shaft of the driving motor 30, the other end of the driving rod 291 is connected with the rotor 293, and the stator 292 is sleeved outside the rotor 293. The stator 292 is fixed on the corresponding material tank body, or is fixed on the support disc of the driving motor 30 and is locked with the support disc through a connecting rod and a screw. The rotor 293 is driven to rotate by the driving motor 30, so as to realize the homogenizing stirring effect. The stirring paddle 32 can adopt a common stirring paddle.

[0118] In some embodiments, the pellet-liquid separation device 15 comprises a pellet-liquid separation filter screen 151 and a cooling liquid recovery tray 152 arranged below the pellet-liquid separation filter screen 151, the circulating cooling device 14 comprises a cooling tank 141, a cooling liquid circulating pipeline 142, a cooling liquid refrigeration storage tank 143 and a refrigeration stirring device 144, the outlet end of the dripping head 100 is connected to the cooling tank 141, one end of the cooling liquid circulating pipeline 142 is connected to the cooling tank 141 and the other end is connected to the pellet-liquid separation filter screen 151, the cooling liquid outlet of the cooling liquid recovery tray 152 is connected to the cooling liquid refrigeration storage tank 143, the pellet-liquid separation filter screen 151 is used to separate the shaped dripping pills 19 from the cooling liquid, the separated cooling liquid flows into the cooling liquid recovery tray 152 and then flows back to the cooling liquid refrigeration storage tank 143 through the cooling liquid outlet of the cooling liquid recovery tray 152 for recycling, the refrigeration stirring device 144 is connected to the cooling liquid refrigeration storage tank 143 and is used to refrigerate and stir the cooling liquid in the cooling liquid refrigeration storage tank 143, the cooling liquid refrigeration storage tank 143 is connected to the cooling tank 141 through a cooling liquid supply pipeline 145, a cooling liquid circulating pump 146 is arranged on the cooling liquid supply pipeline 145, and the cooling liquid in the cooling liquid refrigeration storage tank 143 is pumped into the cooling tank 141 through the cooling liquid circulating pump 146.

[0119] The inner layer material is delivered to the inlet of the inner layer material guide pipe 1 of the dripping head 100 through the inner layer material delivery pipe 6, the middle layer material is delivered to the inlet of the middle layer material delivery channel 4 of the dripping head 100 through the middle layer material delivery pipe 8, and the outer layer material is delivered to the inlet of the outer layer material delivery channel 5 of the dripping head 100 through the outer layer material delivery pipe 10. Through the guide effect of the inner layer material guide pipe 1, the middle layer material delivery channel 4 and the outer layer material delivery channel 5, the materials finally flow out of the three concentric circles at the same time and drop into the cooling liquid below. The material flowing out of the dripping head 100 belongs to the water phase material at the outermost layer, which is subjected to the surface tension effect in the cooling liquid oil phase liquid to form a spherical structure and seamlessly wraps the middle layer and inner layer materials inside the spherical structure. The three-layer dripping pills 19 are obtained through condensation and fixation during the flow in the cooling liquid circulating pipeline 142.

[0120] In some embodiments, the refrigeration stirring device 144 comprises a cooling liquid stirring device 1440, a cooling coil 1441 and a refrigeration machine 1442, the cooling coil 1441 is a spiral coil, the cooling coil 1441 is arranged in the cooling liquid refrigeration storage tank 143, and the two ports of the cooling coil 1441 are connected to the refrigeration machine 1442; the cooling liquid stirring device 1440 comprises a cooling liquid stirring paddle 14401, a driving connecting rod 14402 and a stirring driving motor 14403, the output shaft of the stirring driving motor 14403 is connected to one end of the driving connecting rod 14402, the other end of the driving connecting rod 14402 is connected to the cooling liquid stirring paddle 14401, and the cooling liquid stirring paddle 14401 is arranged in the internal space formed by the winding of the cooling coil 1441.

[0121] In the drop pill process, the cooling liquid generally uses oily liquid paraffin or dimethyl silicone oil and other food or pharmaceutical processing aids. They are also high molecular weight liquid oils, which have the characteristic of increasing viscosity with decreasing temperature. In the refrigeration process, due to the high viscosity and poor flowability of the cooling liquid, the temperature of the cooling liquid at the bottom of the cooling liquid storage tank 143 is low, and the temperature of the cooling liquid at the top is high. Due to the uneven temperature, the temperature of the pumped cooling liquid (i.e. the cooling liquid entering the cooling tank 141) is also unstable, which leads to unstable pill forming. In this embodiment, the cooling coil 1441 is provided, and the refrigeration machine 1442 continuously sends the refrigerant (frozen water or high-pressure refrigerant) into the inlet of the cooling coil 1441 and withdraws it from the outlet, so as to cool the cooling coil 1441. The cooling liquid stirring paddle 14401 is arranged in the internal space formed by the winding of the cooling coil 1441. Through the rotation of the cooling liquid stirring paddle 14401, the temperature of the cooling liquid in the cooling liquid storage tank 143 is uniform, thereby stabilizing the temperature of the cooling liquid during drop pill forming and improving the pill forming performance.

[0122] Example Three

[0123] The present embodiment provides a multi-layer drop pill production method, which is produced by using the multi-layer drop pill production system described in Example Two, comprising the following steps:

[0124] The temperature of the outer layer material is controlled by adding a heat preservation liquid into the outer layer material constant temperature jacket 18 and the outer layer constant temperature liquid heat preservation cavity 11, and the constant temperature temperature is 40-80℃; the temperature of the middle layer material is controlled by adding a heat preservation liquid into the middle layer material constant temperature jacket 17 and the middle layer constant temperature liquid heat preservation cavity 9, and the constant temperature temperature is 35-45℃; the temperature of the inner layer material is controlled by adding a heat preservation liquid into the inner layer material constant temperature jacket 16 and the inner layer constant temperature liquid heat preservation cavity 7, and the constant temperature temperature is 38-43℃; temperature sensors and heaters are arranged in each heat preservation liquid, the temperature detected by the temperature sensor is compared with the set temperature, a PID proportional integral differential control algorithm is used to control the output power of the heater, and the temperature of the heat preservation liquid is stably controlled at the set temperature; the refrigeration machine 1442, the cooling liquid circulating pump 146 and the stirring drive motor 14403 are turned on to control the uniform and stable temperature of the cooling liquid;

[0125] The outer layer material is placed in the outer layer material tank 1330, the middle layer material is placed in the middle layer material tank 1320, and the inner layer material is placed in the inner layer material tank 1310;

[0126] After the temperature of each layer of material is balanced, the outer layer material tank bottom valve 27, the outer layer material pump 28, the middle layer material tank bottom valve 25, the middle layer material pump 26, the inner layer material tank bottom valve 22 and the inner layer material pump 23 are turned on, and each layer of material is transported to the drop head 100 and flows into the cooling liquid at the outlet end of the drop head 100 at the same time;

[0127] In the cooling liquid, the outer layer material is formed into a spherical structure by surface tension, and the middle layer and inner layer materials are wrapped inside the spherical structure, and then gradually solidified into a three-layer drop pill 19. After that, the drop pill 19 and the cooling liquid are separated by the pill liquid separation filter screen 151 until the material is used up.

[0128] The separated drop pill 19 and the oil-removing cloth are placed in the drying rotating cage 221. Dry air is introduced into the sealed box 210 through the air inlet 212. The rotating cage driving motor 222 and the fan 224 are turned on. During the rotation of the drying rotating cage 221, the drop pill 19 and the oil-removing cloth inside the drying rotating cage 221 are constantly rolling and being blown, and the water on the surface of the drop pill 19 is gradually evaporated. The oil-removing cloth and the drop pill 19 contact during the rolling process, gradually absorbing the cooling liquid on the surface of the drop pill 19, achieving the drying and oil-removing of the drop pill 19.

[0129] Among them, after the outer layer material is placed in the outer layer material tank 1330, negative pressure is extracted from the outer layer material tank 1330 to eliminate bubbles in the outer layer material. The negative pressure extraction time is 10-60 minutes, and no obvious bubbles are observed.

[0130] The rotating speed of the outer layer material pump 28 is adjustable and is 5-800 RPM. The rotating speed of the middle layer material pump 26 is adjustable and is 5-800 RPM. The rotating speed of the inner layer material pump 23 is adjustable and is 5-800 RPM. The refrigeration temperature of the refrigeration machine 1442 for the cooling liquid is adjustable and is 3-25℃. The frequency of the cooling liquid circulating pump 146 is adjustable and is 5-50 HZ. The homogenizing and stirring time of the inner layer material in the inner layer material tank 1310 is 1-30 minutes.

[0131] As shown in Table 6, three process examples of Huanglong drop pills prepared by the multi-layer drop pill production method of the present embodiment are shown.

[0132] Table 6 Huanglong drop pill preparation process

[0133] Among them, the middle layer homogenizing and stirring rotating speed weight ratio refers to the ratio of the rotating speed of the homogenizing and stirring in the middle layer material tank 1320 to the weight of the remaining material in the tank. The inner layer homogenizing and stirring rotating speed weight ratio refers to the ratio of the rotating speed of the homogenizing and stirring in the inner layer material tank 1310 to the weight of the remaining material in the tank. The outer layer material temperature, the middle layer material temperature and the inner layer material temperature are respectively maintained stable by constant temperature control of the temperature of the corresponding heat preservation liquid.

[0134] As shown in Table 7, the drop pill preparation effect comparison of the three processes in Table 6 is shown.

[0135] Table 7 Production process drop pill preparation effect comparison

[0136] The production yield refers to the ratio of qualified drop pills obtained after drop pill production to the drop pill production raw material, and the calculation formula is:

[0137] Wherein: a is the production yield, c is the weight of qualified drop pills, and b is the weight of drop pill production raw material; wherein the qualified drop pills are finished products after drying and sieving, and the drop pill production raw material does not include the weight of water.

[0138] The particle size uniformity refers to randomly sampling 10-100 (n) drop pills, measuring the diameter (x i ) of each drop pill, and then calculating the relative standard deviation value (RSD), and the calculation formula is as follows:

[0139] Wherein: S is the standard deviation, is the average value.

[0140] The active ingredient uniformity refers to sampling the drop pills produced in the early, middle and late stages of the production process, and detecting the bifidobacterium content (CFU) in the drop pills, and then calculating the RSD value of the three samples.

[0141] Different process parameters in drop production can produce different production results. As can be seen from Table 7, when the ratio of the feeding rates of the outer material, the middle material and the inner material is 5:3:3, and the cooling liquid temperature is 10℃, the drop pill production yield and other indicators are better.

[0142] The dynamic homogenization process is adopted in the drop production process, and the dynamic homogenization refers to that the rotation speed of material homogenization is not fixed, but is adjusted according to the remaining material weight in the material tank. The adjustment algorithm is that the rotation speed is proportional to the remaining material weight in the tank, that is, as the weight of the material pumped out from the tank decreases, the rotation speed of homogenization also decreases, thereby optimizing the homogenization effect and avoiding excessive agitation of the material due to the high homogenization rotation speed when the material is relatively small, which can generate bubbles and increase the temperature.

[0143] In the drying process of the drop pills, the gradient drying method is adopted, and the gradient drying method mainly refers to that after the sealed box is set, the humidity in the sealed box can be controlled by controlling the dry gas, and in the drying process of the drop pills, the humidity in the sealed box is set to decrease in gradient, and the humidity in the sealed box is gradually reduced in multiple stages, thereby improving the drying efficiency and saving energy, and more importantly, the moisture in the drop pills can also be evaporated, thereby avoiding the problem that the surface is dried while the internal moisture is still locked due to rapid drying.

[0144] The multi-layer drop pill production system and the production method provided by the application can produce three-layer drop pills (including Huanglong drop pills) with better effects, and improve the production yield, particle size uniformity and active ingredient uniformity of the three-layer drop pills.

[0145] The principles and implementations of the present application are described in the specific examples. The above examples are only used to help understand the method of the present application and its core idea. Meanwhile, for those skilled in the art, according to the idea of the present application, the specific implementation and application range will be changed. In summary, the content of the specification should not be understood as a limitation of the present application.

Claims

1. A drop head for preparing a multilayered drop pill, characterized by: The coaxial line is sequentially sleeved with the inner material conduit, the middle material conduit and the outer material conduit from inside to outside; The middle material conduit and the inner material conduit form an annular middle material conveying channel, and the outer material conduit and the middle material conduit form an annular outer material conveying channel; The inlet end of the inner material conduit is communicated with the inner material conveying pipe, and the inner material conveying pipe is arranged in the inner layer constant-temperature liquid heat preservation cavity; The inlet end of the middle material conveying channel is communicated with the middle material conveying pipe, and the middle material conveying pipe is arranged in the middle layer constant-temperature liquid heat preservation cavity; The inlet end of the outer material conveying channel is communicated with the outer material conveying pipe, and the outer material conveying pipe is arranged in the outer layer constant-temperature liquid heat preservation cavity.

2. The drop head for preparing a multilayered drop pill according to claim 1, characterized by: The wall thickness of the outer material conduit is 1.0-6.0 mm, the wall thickness of the middle material conduit is 0.1-1.2 mm, the wall thickness of the inner material conduit is 0.1-1.2 mm, the inner radius r of the inner material conduit is 0.25-5.0 mm, the gap h1 between the middle material conduit and the inner material conduit is 0.2-2.0 mm, the gap h2 between the outer material conduit and the middle material conduit is 0.2-2.0 mm, and the ratio of h2, h1 and r is 1:(0.5-2): (1-4).

3. The drop head for preparing a multilayered drop pill according to claim 1, characterized by: A chamfer is arranged on the outlet end of the outer material conduit.

4. A multi-layered drop pill production system, characterized by: The device comprises a material supply device, a dripping head, a circulating cooling device, a pellet-liquid separation device and a drying and deoiling machine; The dripping head is the dripping head for preparing the multilayer dripping pills according to any one of claims 1-3; The material supply device comprises an inner material supply device, a middle material supply device and an outer material supply device; The discharge port of the inner material supply device is communicated with the inner material conveying pipe, and the inner material conveying pipe is used for conveying the inner material to the inner material conduit through the inner material conveying pipe; The discharge port of the middle material supply device is communicated with the middle material conveying pipe, and the middle material conveying pipe is used for conveying the middle material to the middle material conveying channel through the middle material conveying pipe; The discharge port of the outer material supply device is communicated with the outer material conveying pipe, and the outer material conveying pipe is used for conveying the outer material to the outer material conveying channel through the outer material conveying pipe; The outlet end of the dripping head is communicated with the circulating cooling device, and the material dripping from the dripping head is solidified and formed into the three-layer dripping pills in the cooling liquid of the circulating cooling device, and the dripping pills are conveyed to The pellet-liquid separation device separates the dripping pills and the cooling liquid; The drying and deoiling machine is used for drying and deoiling the separated dripping pills.

5. The multilayered gote pill production system according to claim 4, characterized by: The inner material supply device is externally provided with an inner material constant-temperature isolation sleeve, and the inner material constant-temperature isolation sleeve is communicated with the inner layer constant-temperature liquid heat preservation cavity; The middle material supply device is externally provided with a middle material constant-temperature isolation sleeve, and the middle material constant-temperature isolation sleeve is communicated with the middle layer constant-temperature liquid heat preservation cavity; The outer material supply device is externally provided with an outer material constant-temperature isolation sleeve, and the outer material constant-temperature isolation sleeve is communicated with the outer layer constant-temperature liquid heat preservation cavity.

6. The multilayered gote pill production system according to claim 4, characterized by: The dry deoiling machine comprises a sealed box body and a dry rotating cage assembly, the top of the sealed box body is provided with an openable sealing cover, one side of the sealed box body is provided with an air inlet for introducing dry air, and the other side is provided with an air outlet, the dry rotating cage assembly is arranged in the sealed box body, the dry rotating cage assembly comprises a dry rotating cage, a rotating cage driving motor, a wind collecting box and a fan, the dry rotating cage is rotationally connected in the sealed box body and is driven to rotate by the rotating cage driving motor, the wind collecting box is arranged below the dry rotating cage and is connected with the fan, the wind collecting box is used for guiding the air volume generated by the fan to the dry rotating cage, and the dry rotating cage is placed with deoiling cloth for deoiling treatment of the drop pill.

7. The multilayered gote pill production system according to claim 5, characterized by: The inner layer material supply device comprises an inner layer material tank, the inner layer material tank is fixedly installed in the inner layer material constant temperature sleeve, the inner layer material constant temperature sleeve is arranged on the inner layer material weighing sensor, and the bottom discharge port of the inner layer material tank is connected with the inner layer material conveying pipe. The middle layer material supply device comprises a middle layer material tank, the middle layer material tank is fixedly installed in the middle layer material constant temperature sleeve, the middle layer material constant temperature sleeve is arranged on the middle layer material weighing sensor, and the bottom discharge port of the middle layer material tank is connected with the middle layer material conveying pipe. The outer layer material supply device comprises an outer layer material tank, the outer layer material tank is fixedly installed in the outer layer material constant temperature sleeve, the bottom discharge port of the outer layer material tank is connected with the outer layer material conveying pipe, and the outer layer material conveying pipe is provided with an outer layer material tank bottom valve and an outer layer material pump. The inner layer material tank and the middle layer material tank are both provided with a homogenizing stirring paddle, the homogenizing stirring paddle is provided with a homogenizing stirring sleeve, the outer layer material tank is provided with a stirring paddle, and the homogenizing stirring paddle and the stirring paddle are respectively driven to rotate by driving motors. The pill liquid separation device comprises a pill liquid separation filter screen and a cooling liquid recovery disc arranged below the pill liquid separation filter screen, the circulating cooling device comprises a cooling box, a cooling liquid circulating pipeline, a cooling liquid refrigeration storage box and a refrigeration stirring device, the outlet end of the drop head leads to the cooling box, one end of the cooling liquid circulating pipeline is communicated with the cooling box, and the other end leads to the pill liquid separation filter screen, the cooling liquid outlet of the cooling liquid recovery disc leads to the cooling liquid refrigeration storage box, the refrigeration stirring device is connected with the cooling liquid refrigeration storage box, is used for refrigerating and stirring the cooling liquid in the cooling liquid refrigeration storage box, and the cooling liquid refrigeration storage box is communicated with the cooling box through a cooling liquid supply pipeline.

8. The multi-layered gote pill production system according to claim 4, characterized by: ​ 9. The multilayered gote pill production system according to claim 8, characterized by: The refrigeration stirring device comprises a cooling liquid stirring device, a cooling coil and a refrigeration machine, the cooling coil is arranged in the cooling liquid refrigeration storage tank, and two ports of the cooling coil are connected with the refrigeration machine; the cooling liquid stirring device comprises a cooling liquid stirring paddle, a driving connecting rod and a stirring driving motor, an output shaft of the stirring driving motor is connected with one end of the driving connecting rod, the other end of the driving connecting rod is connected with the cooling liquid stirring paddle, and the cooling liquid stirring paddle is arranged in an internal space formed by the cooling coil.

10. A method for producing multilayered drop pills, characterized by, The multilayer drop pill production system according to any one of claims 4-9, comprising the following steps: The outer layer material constant temperature jacket and the constant temperature liquid in the outer layer constant temperature liquid heat preservation cavity are controlled at constant temperature, the middle layer material constant temperature jacket and the constant temperature liquid in the middle layer constant temperature liquid heat preservation cavity are controlled at constant temperature, and the inner layer material constant temperature jacket and the constant temperature liquid in the inner layer constant temperature liquid heat preservation cavity are controlled at constant temperature; The outer layer material is put into the outer layer material tank, the middle layer material is put into the middle layer material tank, and the inner layer material is put into the inner layer material tank; The outer layer material in the outer layer material tank, the middle layer material in the middle layer material tank and the inner layer material in the inner layer material tank are transported to the drop head, and the materials in each layer flow into the cooling liquid at the same time through the outlet end of the drop head; The outer layer material, the middle layer material and the inner layer material are condensed and fixed in the cooling liquid to obtain three-layer drop pills, and then the drop pills and the cooling liquid are separated through the pill liquid separation device; The separated drop pills are dried and deoiled through the drying and deoiling machine. The separated drop pills are dried and deoiled through the drying and deoiling machine.

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