Ternary herbicidal composition and use thereof

Abstract

The present invention belongs to the field of pesticides, and specifically relates to a ternary herbicidal composition and the use thereof. The ternary herbicidal composition comprises a herbicidally effective amount of active ingredient A, active ingredient B and active ingredient C, wherein the active ingredient A is ethoxysulfuron; the active ingredient B is quinclorac; and the active ingredient C is atrazine. The composition can effectively control and eliminate various weeds such as Gramineae weeds, and has the characteristics of an expanded herbicidal spectrum, a reduced application amount, the capability to produce a synergistic effect and address resistant weeds, etc.

Description

Three-component herbicidal composition and application thereof TECHNICAL FIELD

[0001] The present application belongs to the field of pesticides, and particularly relates to a three-component herbicidal composition and application thereof. BACKGROUND

[0002] Chemical herbicide is the most economical and effective means in the prevention and control of weeds in farmland, but long-term continuous high-dose use of single variety or single action mode of chemical herbicide is prone to cause problems such as weed tolerance and resistance evolution.

[0003] Ethoxysulfuron belongs to the sulfonylurea herbicide, is an acetyl lactate synthesis enzyme (ALS) inhibitor, and is mainly used for preventing and controlling broadleaf weeds and sedge weeds, and has the characteristics of wide application period, convenient use and good safety.

[0004] Quinclorac belongs to the quinoline carboxylic acid herbicide, is a synthetic hormone herbicide, mainly interferes with the activity of hormone regulating enzyme in plants, and the symptoms of weed poisoning are similar to the action of auxin, is mainly used for preventing and controlling barnyard grass, and has a long application period, and is effective in 1-7 leaf period, and has good safety to rice.

[0005] Atrazine belongs to the triazine herbicide, is a photosynthetic system (PSII) inhibitor, is a dry land herbicide, has a wide herbicidal range, good effect, safety to plants, and short residual period, and is suitable for use in the prevention and control of weeds in the fields of crops such as corn, sorghum and broomcorn millet, and orchards and tree nurseries, and has good prevention and control effect on weeds such as barnyard grass, bluegrass, crabgrass and foxtail grass.

[0006] Reasonable compounding or mixing of herbicide compounds has the advantages of expanding the weed spectrum, improving the prevention and control effect, delaying the occurrence and development of weed tolerance and resistance, and the like, and is one of the most effective methods for solving the above problems. Therefore, it is urgent to develop a herbicidal composition variety with high safety, wide herbicidal spectrum, synergistic effect and resistance weed problem solving. SUMMARY

[0007] In order to solve the above problems in the prior art, the present application provides a three-component herbicidal composition and application thereof, which can effectively prevent and control various weeds such as gramineae and is safe to crops, especially sorghum, has the characteristics of expanding the herbicidal spectrum, reducing the application amount, producing synergistic effect and solving the problem of resistant weeds.

[0008] A three-component herbicidal composition comprises herbicidal effective amounts of active ingredient A, active ingredient B and active ingredient C, wherein,

[0009] The active ingredient A is ethoxysulfuron (CAS No.: 126801-58-9);

[0010] Active ingredient B is quinclorac (CAS No. 84087-01-4);

[0011] Active ingredient C is atrazine (CAS No. 1912-24-9);

[0012] wherein the weight ratio of A, B and C is 1-50: 1-500: 1-1000, 2-30: 5-300: 30-900, 5-20: 10-150: 40-300, or 7-10: 15-75: 60-200.

[0013] The mass percentage of A, B and C in the herbicidal composition is 1-95%, preferably 10-80% of the total amount.

[0014] The herbicidal composition further comprises conventional adjuvants, which include carriers and / or surfactants.

[0015] The term "carrier" herein denotes an organic or inorganic, natural or synthetic substance. They facilitate the application of the active ingredients, the carrier is generally inert and must be agriculturally acceptable, in particular by the treated plants. The carrier can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc., or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or aliphatic hydrocarbons, chlorinated hydrocarbons, liquefied gases, etc.

[0016] The surfactants can include emulsifiers, dispersants or wetting agents, which can be ionic or non-ionic. Examples that can be mentioned are salts of polyacrylic acid, lignosulphonic acid, phenolsulphonic or naphthalenesulphonic acid, polymers of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines and substituted phenols, in particular alkylphenols or arylphenols, sulphosuccinic acid salts, taurine derivatives, in particular alkyl taurates, and phosphoric esters of polyols or of polyhydroxyethylated phenols, alkylsulphonates, alkyl- arylsulphonates, alkyl sulphates, lauryl ether sulphates, fatty alcohol sulphates, and sulphated hexa-, hepta- and octadecanol, and sulphated fatty alcohol glycol ethers, furthermore condensates of naphthalene or of naphthalenesulphonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octyl- or nonylphenol, alkylphenyl polyglycol ethers, tributylphenyl polyglycol ether, tristearylphenyl polyglycol ether, alkyl aryl polyether alcohols, alcohol and fatty alcohol / ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, lignosulphite waste liquors, and proteins, denatured proteins, polysaccharides, such as methylcellulose, hydrophobically modified starch, polyvinyl alcohol, polycarboxylates, polyalkoxylates, polyvinylamines, polyvinylpyrrolidone and copolymers thereof. At least one surfactant is required to be present in order to facilitate the dispersion of the active ingredients in water and to enable them to be applied correctly to the plants.

[0017] The above-mentioned compositions can also contain various other components, such as protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, sequestering agents, dyes, colorings and polymers.

[0018] The herbicidal compositions further comprise at least one safener, preferably one or more of benoxacor (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), cloquintocet (CAS: 135590-91-9), cloquintocet-mexyl (CAS: 99607-70-2), gibberellic acid (CAS: 77-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).

[0019] In the context of the present specification, if an abbreviation of the common name of an active compound is used, all conventional derivatives, such as esters and salts, as well as isomers, in particular optical isomers, in particular one or more commercially available forms, are included in each case. If the common name denotes an ester or salt, all other conventional derivatives, such as further esters and salts, free acids and neutral compounds, as well as isomers, in particular optical isomers, in particular one or more commercially available forms, are also included in each case. The chemical name of a compound given indicates at least one compound encompassed by the common name, usually the preferred compound. In the case of sulfonamides, such as sulfonylureas, salts also include salts formed by exchange of the hydrogen atom in the sulfonamide group by a cation.

[0020] In the context of the present application, the salts of the compounds are preferably in the form of the respective alkali metal salts, alkaline earth metal salts or ammonium salts, preferably in the form of the respective alkali metal salts, more preferably in the form of the respective sodium or potassium salts, most preferably in the form of the respective sodium salts.

[0021] The compositions of the present application can be used by the user either directly or after dilution. They can be prepared by the customary methods of processing, i.e. by mixing the active substances with liquid solvents or solid carriers and, if desired, with surfactants such as emulsifiers, stabilizers, wetters, tackifiers, thickeners, foaming agents and the like.

[0022] Specific formulations of the herbicidal compositions are dispersible oil concentrates, aqueous suspensions, suspoemulsions, wettable powders, emulsifiable concentrates, water-dispersible granules (dry flowables), emulsions, microemulsions.

[0023] In short, the compositions of the present application can be mixed with the solid and liquid additives conventionally used in the formulations of the prior art. The amount of active ingredient used varies with the external conditions, such as temperature, humidity, nature of the herbicide used, etc. It can vary within wide limits, for example between 0.001 and 1.0 kg / ha, or more of active substance, but preferably between 0.005 and 750 g / ha, in particular between 0.005 and 500 g / ha.

[0024] In addition, the compositions of the present application can be applied to the leaves of the plants to be treated, i.e. to the weeds, in particular to the surface affected by the weed infestation or susceptible to infestation, by the method of spraying.

[0025] Further, the present application also provides a use of the herbicidal composition in controlling weeds; and provides a method for controlling the growth of unwanted plants, which comprises applying the herbicidal composition to the plants, plant parts, plant seeds or areas where the plants grow. Preferably, the herbicidal composition is used for selectively controlling weeds in useful crops (such as sorghum), more preferably, the useful crops are genetically modified crops or crops treated by genome editing technology.

[0026] The compositions of the present application can be used to treat all plant species and plant parts. Plant species and cultivars can be obtained by conventional breeding methods or by genetic engineering methods. Genetically modified plants (GM plants) are plants whose genetic material has been modified using biotechnology techniques, so that the plants express traits not found in nature. Examples of such traits are resistance to herbicides or pests, tolerance to drought or other growth conditions, enhanced nutritional value, or improved industrial use.

[0027] Genetically modified plant cultivars that can be treated according to the application include plants that are resistant to one or more biotic stresses (pests such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, cold, soil minerals, etc.), or that contain additional desirable traits. Plants can be genetically modified to exhibit traits such as herbicide resistance, insect resistance, modified oil profile, or drought tolerance. Information on useful genetically modified plants and the traits they exhibit can be found, for example, in publicly available databases, such as those maintained by the U.S. Department of Agriculture.

[0028] When the herbicidal compositions of the present application are applied, they exhibit unexpected synergistic effects with respect to the herbicidal activity of the individual components and any binary combinations thereof. The synergistic effects are manifested in reduced application rates, a broader spectrum of weed control, faster and more persistent herbicidal action, which are desirable in weed control practices. In terms of the properties described, the new compositions are clearly superior to existing herbicides, allowing for reduced use and being more environmentally friendly.

[0029] The synergistic herbicidal compositions of the present application also have the following advantages:

[0030] (1) The compositions of the present application are environmentally friendly and readily degradable in the environment.

[0031] (2) The herbicidal compositions of the present application are low in cost and easy to use, and their popularization and application have great economic and social benefits. DETAILED DESCRIPTION

[0032] The following examples are not intended to limit the present application, but merely serve to illustrate how the present application can be practiced. For some weeds, these examples show particularly significant effectiveness. Examples are as follows:

[0033] Pharmacological test (post-emergence stem and leaf spray treatment):

[0034] 1) Test method

[0035] The active ingredients required were purchased from reagent companies or synthesized according to conventional methods. The technical agents were diluted with acetone as the solvent, and a 0.1% emulsifier Tween-80 aqueous solution was used for dilution.

[0036] Each treatment was repeated 4 times, with 3 pots per treatment, 10 seeds of weed were sown in each pot, seedlings were treated during 2-3 leaves, 5 plants were left in each pot, and a total of 15 plants were treated in each treatment.

[0037] The weeds were cultured by potting method, and when the crabgrass reached 5-leaf stage, stem and leaf spraying was uniformly sprayed, and the spraying amount was calculated as 450 kg / ha.

[0038] 2) Data investigation and statistical analysis

[0039] 2.1) Investigation method

[0040] The absolute number investigation method was used, the survival weed whole seedlings were cut off along the soil surface with a blade, and the fresh weight of the weeds was weighed with an analytical balance. For the weeds that have died, the fresh weight was taken as zero.

[0041] 2.2) Investigation time and frequency

[0042] Investigation was carried out 14 days after treatment, and a total of 1 time.

[0043] 2.3) Data statistical analysis

[0044] The Colby method was used to test the combined effect of any two or three mixtures on weeds.

[0045] The green tissue of each treatment was cut and weighed with an electronic balance, and the actual survival rate was calculated: E(%)=(treated area weed fresh weight / control area weed fresh weight) x 100

[0046] The theoretical weed survival rate calculation formula is: E0(%)=X x Y / 100 (binary mixture)

[0047] Wherein X represents the weed survival rate of A when the dosage is P, Y represents the weed survival rate of B when the dosage is Q, E0 represents the theoretical weed survival rate of A+B when the dosage is (P+Q), and E represents the actual weed survival rate of each treatment.

[0048] E0(%)=X x Y x Z x…x N / 100 (n-1) (three or more mixtures)

[0049] Wherein X, Y, Z, N represent the actual survival rates of n kinds of single agents, and n is the number of herbicide varieties.

[0050] When E0-E > 10%, it indicates that a synergistic effect is produced; when E0-E < -10%, it indicates that an antagonistic effect is produced; when E0-E is between ±10%, it indicates that an additive effect is produced.

[0051] The actual control effects of the mixtures on weeds and the statistical results of the joint action evaluation are shown in Table 1 below.

[0052] Table 1 Actual control effects of the mixtures on Digitaria sanguinalis and statistical results of the joint action evaluation

[0053] Note: E(A): the measured fresh weight survival rate of component A treatment at a given dose

[0054] E(B): the measured fresh weight survival rate of component B treatment at a given dose

[0055] E(C): the measured fresh weight survival rate of component C treatment at a given dose

[0056] E(A+B): the measured fresh weight survival rate of binary mixture of component A and component B at a given dose

[0057] E(A+C): the measured fresh weight survival rate of binary mixture of component A and component C at a given dose

[0058] E(B+C): the measured fresh weight survival rate of binary mixture of component B and component C at a given dose

[0059] E(A+B+C): the measured fresh weight survival rate of ternary mixture of components A, B and C at a given dose

[0060] E0(A+B+C): the theoretical fresh weight survival rate of ternary mixture of components A, B and C at a given dose

[0061] E0((A+B)+C): the theoretical fresh weight survival rate of binary mixture of components A and B as a whole and component C at a given dose

[0062] E0((A+C)+B): the theoretical fresh weight survival rate of binary mixture of components A and C as a whole and component B at a given dose

[0063] E0(A+(B+C)): the theoretical fresh weight survival rate of binary mixture of components B and C as a whole and component A at a given dose

[0064] Crop safety test (post-emergence stem and leaf spray treatment):

[0065] The herbicide is dissolved in water to prepare a high-concentration mother liquor, and then diluted with water to the required dose or concentration. A greenhouse potting method is used, and seeds of crops with a good emergence rate (sorghum) are planted, 5 plants of crops are reserved in each pot, and when the sorghum has 3-4 leaves, the stems and leaves are sprayed, 4 times are repeated for each treatment, 3 pots are used for each treatment, and the spraying amount is 450 L / ha. The total phytotoxicity rate of sorghum is investigated 14 days after application, and the fresh weight inhibition rate (%) of crops (sorghum) is calculated according to the fresh weight of the aboveground part of crops:

[0066] Fresh weight inhibition rate (%) = (fresh weight of control crops - fresh weight of treated crops) / fresh weight of control crops * 100

[0067] Table 2: Results of the sorghum safety test

[0068] Through a large number of experiments and explorations, the present application unexpectedly found that the composition has a surprising and unexpected synergistic effect for preventing and removing various gramineous weeds, and the synergistic effect is more significant at a low dose, which can reduce the amount of drug, reduce environmental pollution, and reasonable compounding reduces the cost of agricultural use, and has a good application prospect. At the same time, through testing, it shows good selectivity and excellent synergistic effect in the crop field, and can be developed into a herbicide mixture with wide market value.

Claims

1. A ternary herbicidal composition, characterized by comprising: comprising a herbicidally effective amount of active ingredient A, active ingredient B and active ingredient C, wherein active ingredient A is ethoxysulfuron; active ingredient B is quinclorac; active ingredient C is atrazine.

2. The ternary herbicidal composition according to claim 1, characterized by the weight ratio of A, B and C is 1-50:1-500:1-1000, 2-30:5-300:30-900, 5-20:10-150:40-300 or 7-10:15-75:60-200.

3. The ternary herbicidal composition according to claim 1 or 2, characterized by the mass percentage of A, B and C in the herbicidal composition is 1-95%, preferably 10-80% of the total amount.

4. The ternary herbicidal composition according to claim 1 or 2, characterized by the herbicidal composition further comprises conventional adjuvants, preferably the conventional adjuvants comprise carriers and / or surfactants.

5. The ternary herbicidal composition according to claim 1 or 2, characterized by, the herbicidal composition further comprises at least one safener, preferably the safener is selected from one or more of isoxadifen-ethyl, cyprosulfamide, metcamifen, furilazole and cloquintocet.

6. The ternary herbicidal composition according to any one of claims 1 to 5, characterized in that, the specific formulation of the herbicidal composition is dispersible oil suspension, aqueous suspension, suspoemulsion, wettable powder, emulsifiable concentrate, water dispersible granule, emulsion in water or microemulsion.

7. Use of the ternary herbicidal composition according to any one of claims 1-5 for controlling weeds, preferably the herbicidal composition is used for selectively controlling weeds in useful crops (such as sorghum), more preferably the useful crops are genetically modified crops or crops treated by genome editing technology.

8. A method for controlling unwanted plant growth, comprising applying the ternary herbicidal composition according to any one of claims 1-5 to plants, plant parts, plant seeds or areas where plants grow, preferably the herbicidal composition is used for selectively controlling weeds in useful crops (such as sorghum), more preferably the useful crops are genetically modified crops or crops treated by genome editing technology.

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