Mineral nutritional composition for promoting infant physical growth and use thereof

Abstract

A mineral nutritional composition for promoting infant physical growth and the use thereof. The nutritional composition comprises mineral nutrients. The mineral nutrients comprise iron, magnesium, zinc and selenium, wherein in the mineral nutrients, a mass ratio of the iron, the magnesium, the zinc and the selenium is (1.2-3.2):(12-30):1:(0.006-0.015). Also provided is the use of the nutritional composition in the preparation of a food product for promoting growth and development.

Description

Mineral nutritional composition for promoting infant physical growth and use thereof

[0001] Priority and Related Applications

[0002] This application claims priority to Chinese Patent Application No. 202411909069.6, filed December 23, 2024, entitled “Mineral nutritional composition for promoting infant physical growth and use thereof,” which includes all appendices, and is incorporated by reference in its entirety. TECHNICAL FIELD

[0003] The present application relates to a nutritional composition, and belongs to the field of food nutritional composition, in particular to a nutritional composition and use thereof in infant formula. BACKGROUND

[0004] The infant (including newborn) and larger infant period refers to from birth to one year old, during which the infant's weight and height increase most rapidly, especially in the first three months after birth. The first year is the first growth peak after birth, and the growth rate gradually slows down after the second year until the second growth peak appears during puberty. Weight is one of the most important indicators for evaluating infant growth. Weight is greatly affected by environmental factors, such as nutrition, complementary food addition, disease, etc., and is often used as an indicator for growth detection, reflecting the infant's nutritional status, especially the recent nutritional status. Weight increases most rapidly in the first three months, generally increasing by 600-1000 g per month, and by about 600-800 g per month on average from 3 to 6 months. Height mainly reflects long-term nutritional status, which is significantly affected by genetics, race, and environment. Head circumference is an important indicator reflecting skull growth and brain development. In addition, the World Health Organization (WHO) also recommends using weight-for-age z score (WAZ), length-for-age z score (LAZ), and weight-for-head circumference z score (HCZ) to evaluate infant growth. Good growth and development during the infant period is the foundation of lifelong health, and adequate nutrition is particularly important for promoting physical development and intellectual development during this period.

[0005] Minerals are essential nutrients for the human body and play a vital role in the growth and development of infants (Ref. 1). It is well known that Zn deficiency can lead to growth retardation. However, a recent systematic review showed that the association between the mineral content of the diet and growth and development in infants was not consistent (Ref. 2). This review included 13 studies investigating the association between Zn content in breast milk and infant weight, of which 5 reported the WAZ index of infants, 2 showed a positive association, and 3 found no association. A study on zinc and infant height showed that the amount of zinc intake might be more important for the height of the second half of the infant's life. Other studies found no association between the amount or concentration of zinc intake and length in the first months of life (Refs. 3-7). The reason for this might be the complex interactions between the components of the mineral intake, leading to differences in the results of the studies. High-quality research using the methods of chronobiology and systems biology is needed to understand how various mineral nutrients affect infant growth independently and together.

[0006] A principal component analysis was applied to explore the mineral composition patterns of Guatemalan lactating women and to examine the association between the mineral patterns and anthropometric outcomes of their infants. The results showed that a pattern of high concentrations of Cu, K, Na, Se, and Zn in breast milk was negatively associated with WAZ and LAZ in the first 18-46 days of life (Ref. 8).

[0007] It has been documented that most minerals, such as Mg and Zn, are bound to citrate, which is easily released as an ion and thus can be involved in the overall metabolism (Refs. 9, 10).

[0008] Ref. 11 discloses that the combination of galacto-oligosaccharides, human milk oligosaccharides, and lactoferrin synergistically enhances the utilization of calcium, effectively promotes physical development, and can be produced industrially and used for infants, especially those with special medical conditions. However, no related patents have been found on the combination of minerals to promote physical development.

[0009] Ref.

[0010] Ref. 1: He B-Z, Sun X-J, Quan M-Y, Wang D-H. Macronutrients and energy in milk from mothers of premature infants. Zhongguo Dang Dai Er Ke Za Zhi. (2014) 16:679-83.

[0011] Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2 y: A systematic review. Adv Nutr (2023) S2161-8313: 01326-1.

[0012] Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2 y: A systematic review. Adv Nutr (2023) S2161-8313: 01326-1.

[0013] Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2 y: A systematic review. Adv Nutr (2023) S2161-8313: 01326-1. L, Perheentupa J, Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2 y: A systematic review. Adv Nutr (2023) S2161-8313: 01326-1.

[0014] Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2 y: A systematic review. Adv Nutr (2023) S2161-8313: 01326-1.

[0015] Reference 6: A. S. Cisse, N. Dossou, M. Ndiaye, A. L. Gueye, D. B. Diop, B. Diaham, et al., Stable isotope aided evaluation of community nutrition program: effect of food supplementation schemes on maternal and infant nutritional status, Food Nutr. Bull. 23(3) (2002) 169-173.

[0016] Reference 7: C. Li, N. W. Solomons, M. E. Scott, K. G. Koski, Anthropometry before day 46 and growth velocity before 6 months of Guatemalan breastfed infants are associated with subclinical mastitis and milk cytokines, minerals, and trace elements, J. Nutr. 149(9) (2019) 1651-1659.

[0017] Reference 8: Li C, Solomons NW, Scott ME, Koski KG. Minerals and trace elements in human breast milk are associated with guatemalan infant anthropometric outcomes within the first 6 months. J Nutr. (2016) 146:2067-74.

[0018] Reference 9: B, Stanislowski AG, Hurley LS. Isolation of a low molecular weight zinc binding ligand from human milk. J Inorg Biochem. (1980) 12:71-8.

[0019] Reference 10: B, Yuen M, Glazier C, Litov RE. Magnesium bioavailability from human milk, cow milk, and infant formula in suckling rat pups. Am J Clin Nutr. (1993) 58:392-7.

[0020] Reference document 11: CN115644458A SUMMARY

[0021] Problems to be solved by the invention

[0022] The exploration of mineral nutrients on the growth and development of infants in the above reference documents 1-11 is still mostly limited to the influence of individual components, and the synergistic effect of several mineral combinations on the growth and development of infants has not been attempted.

[0023] Therefore, the present application provides a mineral nutrient composition for promoting the physical growth of infants and its use. By combining four mineral nutrients of iron, magnesium, zinc and selenium in a specific ratio, the nutritional composition can synergistically promote the physical growth of infants.

[0024] Solution to the problem

[0025] In some aspects of the present application, a nutritional composition is provided, which comprises mineral nutrients, the mineral nutrients comprising iron, magnesium, zinc, and selenium;

[0026] In the mineral nutrients, the mass ratio of iron, magnesium, zinc, and selenium is (1.2-3.2):(12-30):1:(0.006-0.015).

[0027] In some embodiments, in the mineral nutrients, the mass ratio of iron, magnesium, zinc, and selenium is (2-3):(20-27):1:(0.007-0.013).

[0028] In some embodiments, the mineral nutrients further comprise copper, manganese, calcium, phosphorus, sodium, potassium, chlorine, and iodine.

[0029] In some embodiments, the nutritional composition further comprises functional ingredients and active proteins.

[0030] In some embodiments, the functional ingredients comprise at least one of myo-inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), eicosapentaenoic acid (ARA), galacto-oligosaccharides, 1,3-dioleic acid 2-palmitic acid triglyceride, lutein, other functional minerals, and nucleotides.

[0031] In some embodiments, the active protein comprises at least one of lactoferrin and casein phosphopeptide.

[0032] In some embodiments, the nutritional composition further comprises a carbohydrate.

[0033] In some preferred embodiments, the carbohydrate comprises lactose.

[0034] In some embodiments, the nutritional composition further comprises one or more of a complex vitamin, a protein, and a fat.

[0035] In some aspects of the present application, there is provided use of a nutritional composition in the manufacture of a foodstuff for promoting growth development.

[0036] In some embodiments, the promoting growth development comprises promoting growth development of an infant; optionally, the promoting growth development comprises promoting increase in height.

[0037] Effects of the invention

[0038] The present application, after a large number of further research, found that four mineral nutrients of iron, magnesium, zinc, and selenium in a specific ratio combination can synergistically promote the physical development of infants.

[0039] The purpose of the present application is to provide a safe and effective nutritional composition and its use, to appropriately combine mineral nutrients of iron, magnesium, zinc, and selenium, to synergistically promote the physical growth of infants. DETAILED DESCRIPTION

[0040] Various exemplary embodiments, features, and aspects of the present application will be described in detail below. The word "exemplary" is used herein to mean "serving as an example, instance, or illustration." Any implementation described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other implementations.

[0041] In addition, in order to better illustrate the present application, numerous specific details are given in the following detailed description. Those skilled in the art will understand that the present application can be practiced without certain specific details. In some other examples, methods, means, apparatuses, and steps that are well known to those skilled in the art are not described in detail in order to highlight the essence of the present application.

[0042] Unless otherwise specified, the units used in the present specification are international standard units, and the numerical values and numerical ranges appearing in the present application should be understood to include systematic errors that are inevitable in industrial production.

[0043] In the present specification, the meaning indicated by "may" includes both the meaning that a certain process is performed and the meaning that a certain process is not performed.

[0044] In the present specification, the reference to "some specific / preferred embodiments", "other specific / preferred embodiments", "embodiments", and the like means that the particular element (e.g., feature, structure, property, and / or characteristic) described in relation to the embodiment is included in at least one embodiment described herein, and can or can not be present in other embodiments. In addition, it should be understood that the described element can be combined in any suitable manner in the various embodiments.

[0045] In the present specification, the numerical range indicated by "numerical value A to numerical value B" means a range including the end point numerical values A and B.

[0046] In the present application, the term "about" or "substantially", "essentially" can mean that a value includes the standard deviation of error of the device or method used to determine the value. The numerical ranges and parameters defining the present application are approximations, and the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation of the measuring equipment or method used in obtaining that numerical value. Therefore, unless otherwise specified, it is understood that every range, quantity, numerical value and percentage stated in this application will be deemed to be modified in all instances by the term "about". Herein, "about" generally means within 2%, preferably within 1%, and more preferably within 0.5% of the stated value or standard deviation.

[0047] In the present application, the term "infant" means a human group of 0 to 6 months of age.

[0048] In the present application, the term "older infant" means a human group of 6 to 12 months of age.

[0049] In the present application, the term "toddler" means a human group of 12 to 36 months of age.

[0050] In the present application, the term "infant" means a human group of 0 to 6 months of age.

[0051] In the present application, the term "infant" means a human group of 0 to 6 months of age.

[0052] (Nutritional composition)

[0053] The present application provides a nutritional composition comprising mineral nutrients, the mineral nutrients comprising iron, magnesium, zinc, selenium.

[0054] In some embodiments, in the mineral nutrients, the mass ratio of iron, magnesium, zinc, selenium is (1.2-3.2):(12-30):1:(0.006-0.015).

[0055] The present application has found that, by combining mineral nutrients iron, magnesium, zinc, selenium in a proper ratio, a synergistic effect of promoting the physical growth of infants and young children is achieved.

[0056] Mineral nutrients

[0057] From the perspective of further promoting the development of infants and young children, in some preferred embodiments, in the mineral nutrients of the nutritional composition, the mass ratio of iron, magnesium, zinc, selenium is (1.5-3.0):(15-28):1:(0.006-0.014).

[0058] In some more preferred embodiments, in the mineral nutrients of the nutritional composition, the mass ratio of iron, magnesium, zinc, selenium is (2-3):(20-27):1:(0.007-0.013), for example, the mass ratio of iron, magnesium, zinc, selenium is 2:20:0.007:1; the mass ratio of iron, magnesium, zinc, selenium is 3:27:1:0.013; the mass ratio of iron, magnesium, zinc, selenium is 2:26:0.008:1.

[0059] In some embodiments, in the nutritional composition, the mineral nutrients comprise, based on the mass of the nutritional composition being 100g: iron (5.5-10mg / 100g), magnesium (61-82mg / 100g), selenium (15.5-40μg / 100g), zinc (1-5mg / 100g).

[0060] In some preferred embodiments, in the nutritional composition, the mineral nutrients comprise, based on the mass of the nutritional composition being 100g: iron (6-9mg / 100g), magnesium (61-78mg / 100g), selenium (20-38μg / 100g), zinc (2-5mg / 100g).

[0061] In some more preferred embodiments, the mineral nutrients in the nutritional composition comprise, per 100 g of the mass of the nutritional composition: iron (6-8 mg / 100 g), magnesium (61-75 mg / 100 g), selenium (22-35 pg / 100 g), zinc (2.5-5 mg / 100 g), for example: iron (6.3 mg / 100 g), magnesium (63.4 mg / 100 g), selenium (22.2 pg / 100 g), zinc (3.2 mg / 100 g); iron (7.6 mg / 100 g), magnesium (68.5 mg / 100 g), selenium (33 pg / 100 g), zinc (2.53 mg / 100 g); iron (5.7 mg / 100 g), magnesium (74.2 mg / 100 g), selenium (22.8 pg / 100 g), zinc (2.9 mg / 100 g).

[0062] For the mineral nutrients of the present application, the mineral nutrients are provided by compounds containing the respective elements.

[0063] In some preferred embodiments, the mineral nutrients include: sodium citrate, potassium chloride, copper sulfate, magnesium sulfate, ferric pyrophosphate, zinc sulfate, manganese sulfate, calcium citrate, tribasic calcium phosphate, potassium iodate, sodium selenite.

[0064] It will be appreciated that in addition to iron, magnesium, zinc, selenium, the mineral nutrients can include other elements, such as copper, manganese, calcium, phosphorus, sodium, potassium, chlorine, iodine, and the like. In some preferred embodiments, the other elements of the mineral nutrients in the nutritional composition, per 100 g of the mass of the nutritional composition, comprise: sodium (165-185 mg / 100 g), potassium (375-400 mg / 100 g), copper (340-360 pg / 100 g), manganese (30-50 pg / 100 g), calcium (340-360 mg / 100 g), phosphorus (190-210 mg / 100 g), iodine (100-110 pg / 100 g), chlorine (270-290 mg / 100 g), for example: sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 pg / 100 g), manganese (40 pg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 pg / 100 g), chlorine (280 mg / 100 g).

[0065] Functional ingredients and active proteins

[0066] In some embodiments, the nutritional composition further comprises functional ingredients and active proteins.

[0067] In some specific embodiments, the functional ingredients comprise at least one of myo-inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), arachidonic acid (ARA), galacto-oligosaccharides, 1,3-dioleic acid 2-palmitic acid triglyceride, lutein, nucleotides, and other functional minerals.

[0068] In some alternative embodiments, other functional minerals can be added to the nutritional composition, such as at least one of key, chromium, nickel, vanadium, silicon, tin, fluorine, and the like.

[0069] The combination of the above-mentioned iron, magnesium, zinc, and selenium ratioed combination mineral nutrients and the above-mentioned functional ingredients can further improve the effect of physical growth of infants and young children.

[0070] In some preferred embodiments, the functional ingredients in the nutritional composition comprise, based on 100 g of the nutritional composition: myo-inositol (38-42 mg / 100 g), taurine (35-40 mg / 100 g), L-carnitine (8-10 mg / 100 g), docosahexaenoic acid (DHA) (95-100 mg / 100 g), arachidonic acid (ARA) (163-165 mg / 100 g), galacto-oligosaccharides (2-5 g / 100 g), 1,3-dioleic acid 2-palmitic acid triglyceride (5-8 g / 100 g), lutein (78-82 μg / 100 g), and / or nucleotides (28-32 mg / 100 g), such as: myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleic acid 2-palmitic acid triglyceride (6.0 g / 100 g), lutein (80 μg / 100 g), and / or nucleotides (30.0 mg / 100 g).

[0071] The present application can further effectively promote the physical development of infants and young children and help them establish a healthy body foundation by the combination of the iron, magnesium, zinc, and selenium ratioed mineral nutrients and the above-mentioned preferred functional ingredient substances.

[0072] In some specific embodiments, the active proteins comprise at least one of lactoferrin and casein phosphopeptide.

[0073] The combination of the above-mentioned iron, magnesium, zinc, and selenium ratioed combination mineral nutrients and the above-mentioned active proteins can further improve the immunity and resistance of infants and young children.

[0074] In some preferred embodiments, the active protein component in the nutritional composition comprises lactoferrin (43-47 mg / 100 g), casein phosphopeptide (38-42 mg / 100 g), for example, lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g), based on the total mass of the nutritional composition being 100 g.

[0075] The mineral nutrients in the present application in combination with the above-mentioned nutrients can further promote the normal development of the body of the infant and enhance the adaptability of the body to changes in the external environment. Therefore, the above-mentioned nutritional composition provided by the present application can help the infant to establish good immunity.

[0076] Carbohydrate

[0077] In some embodiments, the nutritional composition further comprises a carbohydrate.

[0078] The carbohydrate component according to the present application refers mainly to sugar substances. The sugar substances are generally a general term for polyhydroxy aldehydes or polyhydroxy ketones and their polycondensates and certain derivatives, and are generally composed of carbon, hydrogen and oxygen, and the sugar substances can be written as the empirical molecular formula: C n (H2O) n .

[0079] In the present application, as the sugar substances, typically, monosaccharides, disaccharides, polysaccharides or oligosaccharides, etc. can be included.

[0080] In some preferred embodiments, the carbohydrate in the nutritional composition comprises lactose.

[0081] Lactose is the main carbohydrate in breast milk and is the first choice of carbohydrate source for infants. In addition, lactose can also regulate the body, provide appropriate and sufficient nutritional support and promote the absorption of mineral nutrients or other nutrients by the body.

[0082] In some preferred embodiments, the carbohydrate in the nutritional composition is 52-57 g / 100 g, more preferably 53.5-55.5 g / 100 g, for example, 54.2 g / 100 g, based on the total mass of the nutritional composition being 100 g.

[0083] Protein and fat

[0084] In some embodiments, the nutritional composition further comprises a protein and / or a fat.

[0085] In some embodiments, the protein in the present application is selected from at least one of whey protein powder, soy protein isolate, whole milk powder, whole egg powder, lactoferrin, bovine colostrum, amino acid, and protein peptide; and the amino acid is selected from at least one of L-lysine, L-glutamic acid, L-glutamic acid, L-arginine, L-tryptophan, L-glutamine, taurine, L-valine, L-isoleucine, and L-leucine; and the protein peptide is selected from one or more of soy oligopeptide, wheat protein peptide, silkworm chrysalis protein peptide, marine fish oligopeptide powder, cola peptide, amino peptide, and egg albumin peptide.

[0086] In order to provide comprehensive nutrition, the fat structure in the nutritional composition is made more reasonable to meet the nutritional needs of the growth and development of infants and young children. The present application uses various edible oils to supply fat ingredients. The fat can include at least one of saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, OPO structured fats, EPA, and phospholipids, and more specifically, the fat includes one or more of 1,3-dioleic acid 2-palmitic acid triglyceride, sunflower seed oil, coconut oil, and flaxseed oil. In some preferred embodiments, the total mass of the nutritional composition is 100 g, the protein is 8-12 g / 100 g, and the fat is 26-28 g / 100 g, for example, the protein is 10 g / 100 g, and the fat is 27 g / 100 g.

[0087] The combination of the proportioned mineral nutrients provided by the present application with the above-mentioned protein and fat plays an important role in the growth and development, health maintenance, and the like of infants and young children. The protein contains various essential amino acids required by the human body and has a reasonable proportion, which is easy to be absorbed and utilized by the human body. The fat plays an important role in brain development, cardiovascular health, and the like.

[0088] Therefore, the protein and / or fat in the composition of the present application has an irreplaceable role in the nutritional supplementation and growth and development of infants and young children.

[0089] Complex vitamins

[0090] In some embodiments, the nutritional composition further includes complex vitamins.

[0091] The vitamins in the present application include choline components and other vitamin ingredients. For the sake of convenience, the other vitamin ingredients are also referred to as complex vitamins below.

[0092] For the choline components of the present application, there is no particular requirement in principle, and the relevant legal regulations can be used. Typically, the choline components of the present application can be choline chloride.

[0093] In the present specification, “α-TE” refers to the α-tocopherol equivalent, which is the unit of indication of vitamins.

[0094] In the present specification, "RE" refers to retinol equivalent, which is the unit of indication of vitamins.

[0095] In some specific embodiments, the complex vitamins in the nutritional composition comprise at least one of vitamin A, vitamin D, vitamin E, vitamin Kl, vitamin Bl, vitamin B2, vitamin B6, vitamin B 12 nicotinic acid, folic acid, pantothenic acid, vitamin C, biotin, choline.

[0096] The composition of the complex vitamins and the proportioned mineral nutrients described above is beneficial to promote the growth and development of infants and young children, and promote the physical development and intellectual development during this period.

[0097] In some preferred embodiments, the complex vitamins in the nutritional composition comprise, based on the total mass of the nutritional composition being 100 g: vitamin A (355-365 μg RE / 100 g), vitamin D (11-15 μg / 100 g), vitamin E (4-8 mg α-TE / 100 g), vitamin Kl (58-62 μg / 100 g), vitamin Bl (645, 0-660 μg / 100 g), vitamin B2 (490-510 μg / 100 g), vitamin B6 (390-410 μg / 100 g), vitamin B 12 (1-2 μg / 100 g), nicotinic acid (4000-4200 μg / 100 g), folic acid (65-69 μg / 100 g), pantothenic acid (3020-3080 μg / 100 g), vitamin C (65-75 mg / 100 g), biotin (15-17 μg / 100 g), choline (210-220 mg / 100 g), for example: vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin Kl (60.0 μg / 100 g), vitamin Bl (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B 12 (1.5 μg / 100 g), nicotinic acid (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g).

[0098] The composition of the proportioned mineral nutrients and the other nutrients described above of the present application can effectively promote the physical development of infants and young children.

[0099] The present application does not particularly limit the form of the composition, and it can be typically in a liquid or solid form, etc. As other additive ingredients usable in the composition of the present application in addition to the above-mentioned components, there is no particular limitation in principle, and examples include additional active peptide components, other inorganic salts, probiotic components, etc.

[0100] (Use)

[0101] An object of the present application is to provide a use of the nutritional composition described above in the manufacture of a food for promoting growth and development, particularly, the promoting growth and development includes promoting growth and development of infants and young children, further, the promoting growth and development includes promoting increase in height.

[0102] An object of the present application is to provide a method for promoting growth and development, which comprises administering the mineral nutritional composition described above, particularly, the promoting growth and development includes promoting growth and development of infants and young children, further, the promoting growth and development includes promoting increase in height.

[0103] An object of the present application is to provide the mineral nutritional composition described above for use in promoting growth and development, particularly, the promoting growth and development includes promoting growth and development of infants and young children, further, the promoting growth and development includes promoting increase in height.

[0104] The present application helps to promote growth and development (e.g. physical growth) of infants by the synergistic effect of the combination of mineral nutrients iron, magnesium, zinc, and selenium in appropriate proportions.

[0105] The nutritional composition of the present application can be used in the manufacture of a variety of food products, including infant formula, etc. In some specific embodiments, the infant formula includes infant formula milk powder, and is particularly suitable for use in food products for promoting growth and development (e.g. physical growth) of infants.

[0106] The infant formula of the present application includes infant formula milk powder, liquid milk, and breast milk substitutes, etc.

[0107] In the present application, the "infant formula" covers infant formula, follow-on formula, and toddler formula. Generally, infant formula is used as a breast milk substitute from birth, follow-on formula is used as a breast milk substitute from 6-12 months after birth, and toddler formula is used as a breast milk substitute from 12-36 months after birth.

[0108] In some preferred embodiments of the present application, the food product includes infant formula, e.g. "milk-based infant formula".

[0109] In the present application, the "infant formula" refers to a formula suitable for consumption by normal infants, which can meet the normal nutritional needs of infants aged 0-6 months in terms of energy and nutritional ingredients.

[0110] In the present application, the "milk-based infant formula" refers to a product produced and processed only by physical methods, with milk and milk protein products as the main protein source, and with appropriate amounts of complex vitamins, mineral nutrients and / or other raw materials added.

[0111] In some embodiments, the growth and development is evaluated by the growth of the infant in the population of the same age in terms of age-specific weight z-score, age-specific height z-score and / or age-specific head circumference z-score.

[0112] The present application synergistically enhances the effect of promoting the physical growth of infants and young children by combining the proportioned mineral nutrients with or other ingredients. Further, the food containing such a nutritional composition can promote the physical development and intellectual development of infants and young children. Moreover, the above-mentioned proportioned mineral nutrients combined with other ingredients in the nutritional composition can further improve the effect of promoting physical development and intellectual development.

[0113] It should be noted that the specific amount of each raw material in the infant formula containing the nutritional composition of the present application should be adjusted and determined under the premise of meeting the requirements of the product indicators of the formula food (in the place of use). The product performance indicators of the nutritional composition of the present application in the infant formula food, which are not specifically described or listed, should be executed in accordance with the relevant standards and regulations of the place of use, such as "GB 10765-2021 Infant Formula" and "GB 10767-2021 Infant Formula" and relevant standards and regulations.

[0114] Examples

[0115] The embodiments of the present application will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only for illustration of the present application and should not be regarded as limiting the scope of the present application. If the specific conditions are not specified in the examples, the routine conditions or the conditions recommended by the manufacturer are used. If the reagents or instruments used are not specified by the manufacturer, they are all conventional products that can be obtained by purchase.

[0116] Example 1:

[0117] The infant formula contains 2114 kilojoules (kJ) per 100 grams (g) of energy, 10 g / 100 g of protein, 27 g / 100 g of fat, 54.2 g / 100 g of carbohydrates, all of which are from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (6.3 mg / 100 g), magnesium (63.4 mg / 100 g), selenium (22.2 μg / 100 g), zinc (3.2 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, and zinc in this example is 2:20:0.007:1. In addition, the formula contains other nutritional ingredients including myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleic acid 2-palmitic acid triglyceride (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0118] Example 2

[0119] The infant formula contains 2114 kJ / 100 g energy, 10 g / 100 g protein, 27 g / 100 g fat, 54.2 g / 100 g carbohydrates, all from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B12 (0.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (68.5 mg / 100 g), selenium (33 μg / 100 g), zinc (2.53 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 3:27:0.013:1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g). 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (68.5 mg / 100 g), selenium (33 μg / 100 g), zinc (2.53 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 3:27:0.013:1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0120] Example 3

[0121] The infant formula contains 2114 kJ / 100 g energy, 10 g / 100 g protein, 27 g / 100 g fat, 54.2 g / 100 g carbohydrates, all from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B12 (0.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.7 mg / 100 g), magnesium (74.2 mg / 100 g), selenium (22.8 μg / 100 g), zinc (2.9 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 2:26:0.008:1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g). 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.7 mg / 100 g), magnesium (74.2 mg / 100 g), selenium (22.8 μg / 100 g), zinc (2.9 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 2:26:0.008:1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0122] Comparative Example 1

[0123] The infant formula contains 2114 kJ / 100 g energy, 10 g / 100 g protein, 27 g / 100 g fat, 54.2 g / 100 g carbohydrates, all from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B12 (0.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (60.9 mg / 100 g), selenium (15.2 μg / 100 g), zinc (7.6 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 8 : 0.002 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g). 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (60.9 mg / 100 g), selenium (15.2 μg / 100 g), zinc (7.6 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 8 : 0.002 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0124] Comparative Example 2

[0125] The infant formula contains 2114 kJ / 100 g energy, 10 g / 100 g protein, 27 g / 100 g fat, 54.2 g / 100 g carbohydrates, all from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B12 (0.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.3 mg / 100 g), magnesium (42.3 mg / 100 g), selenium (26.4 μg / 100 g), zinc (5.3 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 8 : 0.005 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g). 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.3 mg / 100 g), magnesium (42.3 mg / 100 g), selenium (26.4 μg / 100 g), zinc (5.3 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 8 : 0.005 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0126] Comparative Example 3

[0127] The infant formula contains 2114 kJ / 100 g energy, 10 g / 100 g protein, 27 g / 100 g fat, 54.2 g / 100 g carbohydrates, all from lactose. The vitamins include vitamin A (360 μg RE / 100 g), vitamin D (13.0 μg / 100 g), vitamin E (6.00 mg α-TE / 100 g), vitamin K1 (60.0 μg / 100 g), vitamin B1 (650 μg / 100 g), vitamin B2 (500 μg / 100 g), vitamin B6 (400 μg / 100 g), vitamin B12 (0.5 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chloride (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (83.7 mg / 100 g), selenium (15.2 μg / 100 g), zinc (7.6 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 11 : 0.002 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g). 12 (1.5 μg / 100 g), niacin (4100 μg / 100 g), folic acid (67 μg / 100 g), pantothenic acid (3050 μg / 100 g), vitamin C (70.0 mg / 100 g), biotin (16.0 μg / 100 g), choline (215.0 mg / 100 g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chloride (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (83.7 mg / 100 g), selenium (15.2 μg / 100 g), zinc (7.6 mg / 100 g). The ratio of the four mineral nutrients iron, magnesium, selenium, zinc in this example is 1 : 11 : 0.002 : 1. Further nutritional ingredients contained in the formula include myo-inositol (40 mg / 100 g), taurine (38 mg / 100 g), L-carnitine (9.0 mg / 100 g), docosahexaenoic acid (DHA) (97.0 mg / 100 g), arachidonic acid (ARA) (164.9 mg / 100 g), galacto-oligosaccharides (3.0 g / 100 g), 1,3-dioleoyl-2-palmitoyl glycerol (6.0 g / 100 g), lutein (80 μg / 100 g), nucleotides (30.0 mg / 100 g), lactoferrin (45.0 mg / 100 g), casein phosphopeptide (40.0 mg / 100 g).

[0128] The mass ratios of iron, magnesium, zinc, selenium of the various examples and comparative examples are summarized in Table 1.

[0129] Table 1: Mass ratios of the four mineral nutrients iron, magnesium, selenium, zinc of the various examples and comparative examples

[0130] Test Examples

[0131] The present application recruits 200 infants of ≤1 month old who are fed with pure formula milk, all of which are healthy full-term babies with normal physical development. The infants are divided into 6 groups in a random and double-blind manner, and the number of infants in each group and the corresponding feeding formula are shown in Table 2. The body weight and height of the infants are measured at 6 months, and the age-specific body weight z-score (WAZ), age-specific height z-score (LAZ), and age-specific head circumference z-score (HCZ) are calculated using the WHO Anthro 3.2.2 evaluation software. The measurements are made by the guardian using the special "smart baby scale" provided by the present application, which has a maximum range of 50 kg, a minimum range of 20 g, and an accuracy of 5 g. The height measurement range is 40 cm-80 cm, and the measurement accuracy is 0.1 cm. The height and weight scores of the 3 groups of infants at 3 months are measured, and the weight measurement is made in the naked state with 2 decimal places; the height is measured in the supine position from the heel to the top of the head. The anthropometric statistics of the six groups of infants at 6 months are shown in the following table, and the variance analysis shows that p<0.05 indicates a statistically significant difference.

[0132] The age-specific weight, height, and head circumference of the six groups of infants after intervention are shown in Table 2.

[0133] Table 2: WAZ, LAZ, HCZ experimental results Note: " / " indicates no statistical analysis data.

[0134] From the above variance analysis statistics, it can be seen that the age-specific weight z-score (WAZ) and the age-specific head circumference z-score (HCZ) of the infants fed in the six experimental groups have no significant difference. However, the age-specific length z-score (LAZ) of the infants fed in the six experimental groups has a significant difference (p=0.047). Therefore, it can be considered that the specific proportion of minerals in the present application can increase physical development, while having no significant effect on other growth characteristics.

[0135] Further, it is also observed that the LAZ of the infants in Examples 1-3 is significantly higher than that of the control group. The growth of the infants in Examples 1-3 is better than that of the control group. The proportion of the four minerals in Examples 1-3 is in the range of 2-3:20-27:1:0.007-0.013, which can more obviously obtain the technical effect of the present application.

[0136] It should be noted that although the technical solutions of the present application are introduced with specific examples, those skilled in the art can understand that the present application should not be limited thereto.

[0137] Having described various embodiments of the application, it is to be understood that the above description is meant not to limit and not to encompass all of the possible embodiments covered by the claims. Many modifications and variations of this application can be apparent to those of ordinary skill in the art without departing from the spirit and scope of the described embodiments. It is intended that the scope of the application should only be limited by the appended claims.

Claims

1. A nutritional composition, characterized in that, The nutritional composition comprises a mineral nutrient including iron, magnesium, zinc, selenium; In the mineral nutrient, the mass ratio of iron, magnesium, zinc, and selenium is (1.2-3.2):(12-30):1:(0.006-0.015).

2. The nutritional composition according to claim 1, characterized in that, In the mineral nutrient, the mass ratio of iron, magnesium, zinc, and selenium is (2-3):(20-27):1:(0.007-0.013).

3. Nutritional composition according to claim 1 or 2, characterized in that, The nutritional composition further comprises a functional ingredient and an active protein.

4. Nutritional composition according to any one of claims 1 to 3, characterized in that, The mineral nutrient further comprises copper, manganese, calcium, phosphorus, sodium, potassium, chlorine, and iodine.

5. The nutritional composition according to claim 3, characterized in that, The functional ingredient includes at least one of myo-inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), eicosapentaenoic acid (ARA), galacto-oligosaccharide, 1,3-dioleic acid 2-palmitic acid triglyceride, lutein, other functional minerals, and nucleotides.

6. The nutritional composition of claim 3, wherein, The active protein includes at least one of lactoferrin and casein phosphopeptide.

7. Nutritional composition according to any one of claims 1 to 6, characterized in that, The nutritional composition further comprises a carbohydrate, Preferably, the carbohydrate includes lactose.

8. Nutritional composition according to any one of claims 1 to 7, characterized in that, The nutritional composition further comprises one or more of a complex vitamin, a protein, and a fat.

9. Use of the nutritional composition according to any one of claims 1-8 in the preparation of a food for promoting growth and development.

10. Use according to claim 9, characterized in that, The promoting growth and development includes promoting growth and development of an infant; Optionally, the promoting growth and development includes promoting growth in height.

Images