Press-through package

Abstract

This press-through package has: a container body that includes a plastic sheet having a plurality of content accommodation recesses; solid contents that are accommodated in the plurality of content accommodation recesses; and a lid member that closes openings of the plurality of content accommodation recesses. The lid member has: a fragile substrate that includes a resin film; a print layer that is disposed on the fragile substrate; and a sealant layer. The print layer is formed by a printing method other than intaglio printing, or comprises a vapor deposition layer on the fragile substrate.

Description

Press-through pack packaging

[0001] This invention relates to a press-through pack packaging.

[0002] Press-through pack packaging (hereinafter also referred to as "PTP packaging") is widely used as packaging for pharmaceutical tablets and the like (see, for example, Patent Documents 1 to 3).

[0003] International Publication No. 2022 / 113566, Japanese Patent Publication No. 2022-551332, Japanese Patent No. 7444761

[0004] The PTP packaging has a configuration as shown in Figures 11 and 12, for example. Figure 11 is a plan view of the PTP packaging, and Figure 12 is a cross-sectional view of the main part along line A-A in Figure 11.

[0005] As shown in Figure 12, a typical PTP package 100 has a container body 20 and a lid 10. The container body 20 has content-retaining recesses 110, and solid contents 130 such as tablets are contained in multiple content-retaining recesses 110.

[0006] In some cases, notches 120 are provided between the multiple content-retaining recesses 110.

[0007] Furthermore, the lid material 10 is made of a film that is easily torn, and this lid material 10 completely closes the openings 110A of the numerous contents-containing recesses 110.

[0008] The PTP packaging 100 can be opened by pressing on the bottom 110B of the content-containing recess 110 with a finger or the like, causing the solid contents 130 to pierce through the lid material 10. Alternatively, the packaging can be opened by cutting along the perforations 120 for each individual content-containing recess 110 or for each of the multiple content-containing recesses 110, and then piercing through the lid material 10.

[0009] For the lid material 10, aluminum foil coated with lacquer is used.

[0010] This PTP packaging 100 can be opened and the solid contents 130 removed simply by pressing it with a finger, making it extremely easy to handle.

[0011] In recent years, there has been a growing demand for lid materials 10 that do not use aluminum foil, due to environmental considerations.

[0012] Therefore, there is a need for a novel press-through pack packaging that uses resin film (plastic film) as an alternative material to aluminum foil for the lid.

[0013] In view of the above problems, the present invention aims to provide a novel press-through pack packaging body using a resin film as the lid material.

[0014] One aspect of this disclosure provides a press-through pack packaging comprising: a container body including a plastic sheet having a plurality of content-containing recesses; solid contents contained in each of the plurality of content-containing recesses; and a lid material that closes the openings of the plurality of content-containing recesses, wherein the lid material comprises a fragile substrate including a resin film, a printed layer disposed on the fragile substrate, and a sealant layer, wherein the printed layer is formed by a printing method other than intaglio printing, or the fragile substrate has a vapor-deposited layer.

[0015] According to the present invention, a novel press-through pack packaging body using a resin film as the lid material can be provided.

[0016] Figure 1 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 2 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 3 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 4 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 5 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 6 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 7 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 8 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 9 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 10 is a cross-sectional diagram showing an example of a lid material for a press-through pack packaging according to the present disclosure. Figure 11 is an explanatory diagram showing an example of a press-through pack packaging according to the present disclosure. Figure 12 is a cross-sectional view taken along line A-A in Figure 11. Figure 13 is an explanatory diagram showing an example of the printed layer of the lid material of the press-through pack packaging of the present disclosure. Figure 14 is an explanatory diagram showing an example of the printed layer of the lid material of the press-through pack packaging of the present disclosure. Figure 15 is an explanatory diagram of a method for evaluating printed lines. Figure 16 is an explanatory diagram showing an example of the printed layer of the lid material of the press-through pack packaging of the present disclosure, and illustrates the magnified view of printed minute characters.

[0017] Hereinafter, preferred embodiments of a press-through pack packaging according to one embodiment of the present disclosure (hereinafter referred to as "this embodiment") will be described in detail, with reference to the drawings as appropriate. The same reference numerals are used for identical components, and redundant descriptions are omitted. Furthermore, since the drawings are schematic diagrams for illustrative purposes, the scale of each component may differ from that of actual components. For this reason, the dimensional ratios in the drawings are not limited to those shown. In the following description, the notation "A to B" means "A or greater and B or less".

[0018] In this specification, the names of components, such as "first surface" and "second surface," may be preceded by prefixes like "first," "second," etc. These prefixes are merely used to identify each component and prevent confusion during explanation; they do not indicate arrangement, priority, or anything of that sort. Therefore, when there is no particular risk of confusion or when referring to them collectively, they can simply be described as "surface." [Laminates for packaging materials]

[0019] Figures 1 to 10 are cross-sectional explanatory diagrams showing an example of the lid material of a PTP packaging according to this embodiment. Figures 1 to 10 are cross-sectional views along the lamination direction of the layers contained in the lid material of the PTP packaging according to this embodiment.

[0020] Figure 11 is a plan view showing a specific example of the PTP packaging of this embodiment. Figure 12 is a cross-sectional view taken along line A-A in Figure 11, and is a cross-sectional view of a key part of the surface passing through the content-containing recess.

[0021] Figures 13 to 16 show examples of the printed layer of the lid material of the PTP packaging in this embodiment.

[0022] The PTP packaging 100 of this embodiment may have a container body 20 and a lid material 10. The PTP packaging 100 of this embodiment may also contain solid contents 130. Therefore, the PTP packaging 100 of this embodiment may have a container body 20, a lid material 10 and solid contents 130.

[0023] (1) Container body The container body 20 may include a plastic sheet having a plurality of content-containing recesses 110. The plastic sheet may be flexible. The content-containing recesses 110 can be formed by deep drawing the plastic sheet. In the example in Figure 11, eight content-containing recesses 110 are formed in a 2x4 arrangement. However, the number and arrangement of content-containing recesses 110 in the PTP packaging 100 of this embodiment are not limited to the example in Figure 11, and may be any number and arrangement. The content-containing recesses 110 in the PTP packaging 100 of this embodiment may be arranged regularly on the container body 20 as shown in Figure 11, or they may be arranged randomly.

[0024] The plastic sheet of the container body 20 may be a single-layer structure or a multi-layer structure. Examples of materials for a single-layer plastic sheet include polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyamide, and polycarbonate. The plastic sheet may also be a multi-layer structure obtained by coating the single-layer plastic sheet with a gas barrier resin such as polyvinylidene chloride (PVDC) or ethylene-vinyl alcohol copolymer (EVOH), or by co-extrusion. Furthermore, the container body 20 may be formed by creating a content-containing recess 110 in the plastic sheet by deep drawing, and then laminating an inorganic vapor-deposited film such as silicon dioxide or aluminum oxide to provide gas barrier properties. Therefore, the container body 20 may be a laminate of a plastic sheet and an inorganic vapor-deposited film. Examples of deep drawing include vacuum forming, pressure forming, and press forming.

[0025] (2) Solid contents The solid contents 130 can be contained in each of the multiple contents-containing recesses 110. Examples of solid contents 130 include pharmaceutical preparations such as tablets, lozenges, and capsules, or solid seasonings such as curry roux, and food products such as chocolate, candy, and confectionery. The solid contents 130 may contain only one type of solid contents 130 in one container body, or it may contain multiple different types of solid contents 130. Also, one contents-containing recess 110 may contain one solid contents 130, or it may contain two or more solid contents 130.

[0026] (3) Lid material The lid material 10 can close the openings 110A of the multiple content-storage recesses 110. The lid material 10 may cover the entire first surface 20A of the container body 20, including the openings 110A of the content-storage recesses 110. The first surface 20A of the container body 20 is the surface on which the openings 110A of the content-storage recesses 110 are located.

[0027] In the example shown in Figures 11 and 12, the plastic sheet of the container body 20 is provided with a total of eight content-holding recesses 110. Therefore, the lid material 10 may be heat-sealed to the container body 20 so as to close all of the openings 110A of these eight content-holding recesses 110.

[0028] As an alternative material to the aluminum foil conventionally used as the lid material 10 for PTP packaging 100, plastic film materials such as PET film can be used. However, many plastic film materials have the characteristic of stretching when the film is pressed, which may make it difficult to open and remove the solid contents 130 when applied to the lid material 10. Therefore, it is preferable that the lid material 10 be made of a film that is easily broken. Furthermore, it is conceivable to use a brittle base material for the lid material 10.

[0029] Figure 1 shows an example of the configuration of a lid material 10 applied to the PTP packaging 100 of this embodiment. As shown in Figure 1, the lid material 10 comprises a fragile base material 1, a printed layer 2, and a sealant layer 3. That is, the lid material 10 has a fragile base material 1 containing a resin film, a printed layer 2 disposed on the fragile base material 1, and a sealant layer 3.

[0030] Furthermore, the lid material 10 may include a brittle base material 1 that is easily broken as a base material. By including the brittle base material 1 in the lid material 10, the solid contents 130 can be easily broken through the lid material 10 and opened by pressing from the bottom 110B of the contents-containing recess 110 with a finger or the like.

[0031] (3-1) Regarding the components of the lid material (3-1-1) Fragile base material (3-1-1-1) Mechanical properties of the fragile base material Any resin film can be used for the fragile base material 1, and a resin film that is easily broken is preferably used. Among the properties described below, a base material in which the puncture strength is 8.0 N or less and both the MD tensile elongation and TD tensile elongation are 50% or less can be called a fragile base material.

[0032] (Maximum uneven height) The maximum uneven height of the vulnerability substrate 1 may be 0.5 μm or more and 9.0 μm or less. The maximum uneven height in this specification means the maximum height roughness Rz defined in JIS B 0601 (2013).

[0033] By setting the maximum uneven height of the vulnerability substrate 1 to 9.0 μm or less, it is possible to prevent the ink from running off in the printing layer 2 and to form the printing layer printed with the ink into a desired shape. Therefore, when a figure or the like that needs to be read by an optical terminal such as a barcode is printed on the printing layer 2, the reading accuracy can be improved. When measuring the maximum uneven height of the vulnerability substrate 1, the vulnerability substrate 1 is embedded in a photocurable resin, cut with a microtome using a diamond knife, and the cross section is observed with an optical microscope. Then, it is obtained by observing at a magnification of 500 (about 174 μm × 131 μm) and measuring the height of the highest peak and the lowest valley within the measurement range.

[0034] By setting the maximum uneven height of the vulnerability substrate 1 to 0.5 μm or more, the productivity of the vulnerability substrate 1 can be increased. The maximum uneven height of the vulnerability substrate 1 may be 0.9 μm or more and 8.5 μm or less.

[0035] (Tensile strength) The MD tensile strength of the vulnerability substrate 1 may be 20 MPa to 50 MPa. By setting the MD tensile strength to 50 MPa or less, the vulnerability substrate 1 can be broken particularly easily. Therefore, for the PTP package 100 provided with the lid material 10 including the vulnerability substrate 1, the push-through property can be particularly improved. That is, the PTP package 100 can be made such that the solid content 130 can be easily taken out. MD is an abbreviation for Mold Direction and means the flow direction during film production.

[0036] By setting the MD tensile strength to 20 MPa or more, film breakage in the processing step can be prevented. The processing step means the step of processing the lid material 10.

[0037] The MD tensile strength of the vulnerability substrate 1 may be 22 MPa to 38 MPa, or may be 24 MPa to 36 MPa.

[0038] As a method for controlling the MD tensile strength of the brittle base material 1, for example, a method of changing the crystallinity of the resin or stretching can be mentioned. When the crystallinity is increased or stretching is performed, the tensile strength tends to increase.

[0039] The TD tensile strength of the brittle base material 1 may be 20 MPa to 50 MPa. By setting the TD tensile strength to 50 MPa or less, the brittle base material 1 can be made particularly easy to break. For this reason, the push-through property of the PTP package 100 provided with the lid material 10 including the brittle base material 1 can be particularly enhanced. That is, the PTP package 100 can be made such that the solid content 130 can be easily taken out. TD is an abbreviation for Transverse Direction and means a direction perpendicular to the MD direction.

[0040] By setting the TD tensile strength to 20 MPa or more, film breakage in the processing step can be prevented.

[0041] The TD tensile strength of the brittle base material 1 may be 21 MPa to 38 MPa, or may be 22 MPa to 37 MPa.

[0042] As a method for controlling the TD tensile strength of the brittle base material 1, for example, a method of changing the crystallinity of the resin or stretching can be mentioned. When the crystallinity is increased or stretching is performed, the tensile strength tends to increase.

[0043] The tensile strengths of MD and TD can be measured in accordance with JIS K 7127 (1999). The test piece can have a width of 15 mm, and the distance between chucks can be 50 mm. Also, the tensile speed can be set to 100 mm / min, the maximum load when the test piece breaks can be used as the breaking strength, and the elongation rate at that time can be measured as the tensile elongation.

[0044] (Tensile elongation) The brittle base material 1 may have both an MD tensile elongation and a TD tensile elongation of 50% or less, 20% or less, or 10% or less. Within this range, the push-through property is good. Particularly good push-through property can be obtained when both the MD tensile elongation and the TD tensile elongation are 10% or less. The MD tensile elongation and the TD tensile elongation may be different values or the same value.

[0045] (Puncture Strength) The puncture strength of the fragile base material 1 may be 8.0 N or less, 2.5 N to 8.0 N, or 2.5 N to 4.0 N. By setting the puncture strength of the fragile base material 1 to 8.0 N or less, the lid material 10 can be made particularly easy to break. For this reason, the push-through properties of the PTP packaging 100 equipped with the lid material 10 containing the fragile base material 1 can be particularly improved. In other words, the PTP packaging 100 can be made from which the solid contents 130 can be easily removed. Furthermore, by setting the puncture strength to 2.5 N or more, film tearing during the processing can be prevented.

[0046] The puncture strength can be measured in accordance with JIS Z 1707 (2019). For example, a semicircular needle with a diameter of 1.0 mm and a tip radius of 0.5 mm may be inserted perpendicularly into the sample surface at a speed of 50 ± 5 mm per minute, and the maximum load until the needle penetrates the sample may be measured. The measurement can be performed by inserting the needle from the first surface 1A, which is the surface of the fragile substrate 1 closest to the solid contents 130, toward the second surface 1B, which is the surface furthest from the solid contents 130.

[0047] (3-1-1-2) Components contained in the fragile substrate The fragile substrate 1 can be a resin film made using any resin selected from the group of resins, which includes resins with a smaller molecular weight than resins used in the field of ordinary packaging materials, resins to which particles such as inorganic particles have been added, resins whose degree of crystallinity has been controlled with nucleating agents, resins that are a blend of non-miscompatible polymers, etc., or a resin film made by combining two or more resins selected from the above group of resins.

[0048] As a resin with a smaller molecular weight than those commonly used in packaging materials, a low-molecular-weight design is possible. For example, resins with an MFR (compliant with JIS K 7210-1 (2014), test temperature 230°C) in the range of greater than 10 g / 10 min and less than 80 g / 10 min can be used.

[0049] By increasing the MFR of a resin with a smaller molecular weight than that used in the field of conventional packaging materials to more than 10.0 g / 10 min, the push-through properties of the PTP packaging 100 equipped with a lid material 10 containing a fragile base material 1 can be particularly improved.

[0050] By reducing the MFR of resins with a smaller molecular weight than those typically used in packaging materials to less than 80.0 g / 10 min, the productivity of film formation for fragile substrates can be increased.

[0051] MFR stands for Meltmass Flow Rate.

[0052] (Inorganic particles) As a resin film using a resin to which particles such as inorganic particles have been added, specifically, for example, a brittle polypropylene film containing inorganic particles may be used. By including such inorganic particles in the fragile substrate 1, the fracture initiation point can be increased and the ease of opening can be improved.

[0053] The inorganic particles contained in the fragile substrate 1 are not particularly limited, and examples include amorphous alumina silicate, silica, alumina, talc, kaolin, mica, wollastonite, clay, calcium carbonate, glass fiber, aluminum sulfate, etc. The fragile substrate 1 may contain one or more inorganic particles, particularly selected from talc and titanium dioxide.

[0054] The inorganic particle content in the fragile substrate 1 is preferably 5 wt% to 60 wt%, and more preferably 5 wt% to 55 wt%. When the inorganic particle content is within the above range, the lid material exhibits particularly good openability, has few impurities, and is highly recyclable.

[0055] The size of the inorganic particles contained in the fragile substrate 1 is not particularly limited. The size of the inorganic particles can be evaluated, for example, by the following procedure. The value measured for the longest length corresponding to the major axis diameter of the inorganic particles is taken as the particle size, and the arithmetic mean of the evaluated inorganic particle sizes can be taken as the average particle size for the inorganic particles. In this case, the average particle size of the inorganic particles is preferably about 5 μm to 100 μm. The particle size of the inorganic particles may be selected based on the thickness of the film layer to be manufactured. When a film with a thickness of 80 μm to 100 μm is made, the average particle size of the inorganic particles used in the film may be between 20 μm and 60 μm.

[0056] The thickness of the fragile substrate 1 is not particularly limited, but may be 10 μm to 100 μm, preferably 20 to 50 μm, and more preferably 20 to 40 μm. When the thickness is 10 μm or more, it is easier to achieve tensile strength that can withstand the processing steps, and when it is 100 μm or less, it is easier to achieve particularly good openability.

[0057] (Resin) Examples of resins used in the fragile substrate 1 include polyolefin resins, polyethylene resins, polypropylene resins, and styrene resins. The resins used in the fragile substrate 1 described here refer to examples of resins that the fragile substrate 1 can contain. Therefore, resins contained in resin groups such as resins with smaller molecular weights than those used in the field of ordinary packaging materials, as already described, may also be the resins described here.

[0058] <Polyolefin Resin> The polyolefin resin used in the fragile base material 1 may be a polymer containing monomer units derived from olefins, for example, polyethylene resins, polypropylene resins, etc.

[0059] Polyolefin resins may be used individually or in combination of two or more types.

[0060] <Polyethylene Resin> The polyethylene resin used in the fragile substrate 1 is not particularly limited and may be either an ethylene homopolymer or a copolymer of ethylene and another monomer. Examples of polyethylene resins include ethylene homopolymers; ethylene-α-olefin copolymers such as ethylene-propylene copolymer, ethylene-butene copolymer, and ethylene-octene copolymer; ethylene-(meth)acrylic acid ester copolymers such as ethylene-ethyl acrylate copolymer, ethylene-butyl acrylate copolymer, and ethylene-ethyl acrylate-methyl methacrylate copolymer; and ethylene-vinyl acetate copolymer. Among these, ethylene homopolymers are preferred because the elongation at break tends to decrease as the density increases. In this specification, "(meth)acrylic acid" means methacrylic acid or acrylic acid.

[0061] Furthermore, from an environmental perspective, the polyethylene resin may be bio-polyethylene. In addition, the polyethylene resin may be used alone or in combination of two or more types.

[0062] <Polypropylene Resin> Examples of polypropylene resins used in the fragile substrate 1 include propylene homopolymers, copolymers of propylene and other monomers, and modified products thereof. Among these, propylene homopolymers are preferred from the viewpoint of heat resistance, water vapor barrier properties, and elongation at break. In other words, it is preferable that the fragile substrate 1 contains polypropylene. Furthermore, from the viewpoint of environmental considerations, the polypropylene resin used in the fragile substrate 1 may be bio-polypropylene. In addition, polypropylene resins may be used individually or in combination of two or more types.

[0063] Examples of monomers copolymerizable with propylene include ethylene, 1-butene, isobutylene, 1-pentene, 1-hexene, and other α-olefins. The polymerization form is not particularly limited and may be random copolymer, block copolymer, etc.

[0064] <Styrene-based resins> Examples of styrene-based resins used in the fragile substrate 1 include styrene homopolymers, copolymers of styrene and other monomers (hereinafter also referred to as "styrene-based copolymers"), and mixtures thereof. Examples of styrene homopolymers include styrene (e.g., GPPS (General Purpose Polystyrene)), alkylstyrenes such as α-methylstyrene, etc. Examples of styrene-based copolymers include styrene-(meth)acrylic acid copolymers, styrene-(meth)acrylic acid ester copolymers, styrene-(meth)acrylic acid-(meth)acrylic acid ester copolymers, styrene-acid anhydride copolymers, high-impact polystyrene (e.g., HIPS), styrene-α-methylstyrene copolymers, etc. Furthermore, styrene-based copolymers may also be styrene-butadiene copolymers, hydrogenated styrene-butadiene copolymers, styrene-isoprene copolymers, etc.

[0065] Among these, from the viewpoint of improving heat-sealability with the container body 20, which is the bottom material for PTP, styrene-based elastomers such as styrene-butadiene copolymers and hydrogenated styrene-butadiene copolymers are preferred as the styrene-based resin.

[0066] Furthermore, from a recycling perspective, it is preferable to use the same material as the container body 20, which serves as the bottom material for PTP, as the resin used for the fragile base material 1. Most preferably, a polypropylene resin is used for the resin used for the fragile base material 1.

[0067] The resin used in the fragile substrate 1 may contain a coloring agent. The coloring agent can be used to provide contrast to the printed layer or to protect the contents from external light. When providing contrast to the printed layer, light colors such as white, light yellow, or sepia can be used, and when protecting the contents, yellow, orange, or brown can be used. The coloring agents that can be used include titanium dioxide, zinc oxide, and talc, and titanium dioxide is particularly preferred when providing contrast to the printed layer.

[0068] The coloring agent content can be 0.5 parts by mass or more and less than 20 parts by mass per 100 parts by mass of resin.

[0069] (3-1-2) Sealant Layer Next, the sealant layer 3 has the role of heat-sealing to the container body 20 and closing the contents-holding recess 110. For this reason, it is preferable to place the sealant layer 3 near the surface 10A of the lid material 10 that faces the container body 20. For example, the sealant layer 3 may be placed on the outermost surface of the lid material 10, in which case the surface of the sealant layer 3 will be positioned to include the surface 10A of the lid material 10. A printing layer can also be placed on the surface of the sealant layer 3. In this case, the printing layer 2 and the sealant layer 3 will be laminated in order from the position closest to the surface 10A of the lid material 10.

[0070] The sealant layer 3 is preferably made of a material that enhances the ease of breaking the lid material 10. The sealant layer 3 can be formed, for example, by dispersing polyethylene resin or polypropylene resin in a solvent and applying it. Alternatively, the sealant layer 3 may be formed by applying acrylic heat seal varnish or vinyl acetate heat seal varnish. (3-1-3) Printed layer The lid material 10 may have a printed layer 2. Specifically, the printed layer 2 may be formed on the fragile substrate 1. The printed layer 2 is provided to display the product name or other information. Microprinting or the like can also be provided for the purpose of preventing counterfeiting.

[0071] The printed layer 2 may be formed on the entire surface of the fragile substrate 1 or the surface forming the printed layer, or it may be formed only on a part of the surface forming the printed layer. The same applies to the second printed layer 21, which will be described below.

[0072] Gravure printing is commonly used in the packaging materials field due to its productivity and wide color gamut. However, because gravure printing uses intaglio printing, the ink in the recessed areas is not easily transferred to rough surfaces. As a result, the printing accuracy on rough surfaces is not high, leading to variations in printing and difficulty in printing fine details.

[0073] Therefore, in the PTP packaging of this embodiment, a printing method other than intaglio printing, i.e., a method other than intaglio printing, may be used to form the printed layer 2. Accordingly, the printed layer 2 may be formed by a printing method other than intaglio printing (hereinafter also referred to as "non-intaglio printing"). As non-intaglio printing, one or more selected from, for example, letterpress printing, lithographic printing, stencil printing, and plateless printing can be used. Using non-intaglio printing for the printed layer 2 enables highly accurate printing on the fragile substrate 1. Among these, lithographic printing and letterpress printing have excellent ink transferability and productivity, so the printed layer may be formed by one or more selected from lithographic printing and letterpress printing. Flexographic printing may be used as letterpress printing. Offset printing may be used as lithographic printing, and EB offset printing is preferably used. EB in EB offset printing stands for Electron Beam. The printed layer 2 can more preferably be formed by flexographic printing. For plateless printing, inkjet printing or wet toner printing can be used. When using inkjet printing, an ink-receiving layer may be formed on the printing surface, which is the surface that forms the printed layer, as needed.

[0074] The thickness of the printed layer 2 is preferably in the range of 0.1 μm to 5 μm. By making it 5 μm or less, the push-through properties can be particularly improved.

[0075] Examples of printed characters and graphics in the printing layer 2 include product names of contents, explanatory text such as handling instructions, pictures, micro-text and other fine-text / fine-text printing for tamper-proof purposes, barcodes, and two-dimensional codes. Other examples of printed characters and graphics in the printing layer 2 include letters and symbols, allowing appropriate information to be formed on the printing layer 2 depending on the solid contents contained in the PTP packaging.

[0076] The printing layer 2 may include security printing that includes one or more types selected from microcharacters and micrographics.

[0077] Micro-characters may be made with a character height of 500 μm or less. If the character height is 500 μm or less, it becomes difficult to distinguish the formed characters with the naked eye, and even difficult to recognize them as characters, thus increasing the anti-counterfeiting effect. The smaller the micro-characters, the more difficult they are to counterfeit, but there is a problem in that they are easily affected by the substrate and usage conditions. In particular, since the maximum height of the unevenness of the fragile substrate 1 may be large, if micro-characters are printed using gravure printing, the printed characters may become distorted and unrecognizable. Therefore, by using non-intaglio printing for the printing layer 2, it is possible to print in the desired shape while preventing the printed characters from becoming distorted even when the maximum height of the unevenness of the fragile substrate 1 is large.

[0078] Figure 16 shows an example of printing micro-characters 160, which are micro-characters representing a date such as R6-9-10, on the lower left corner of the lid material 10. These characters are not normally visible but become visible when magnified using a magnifying glass or other magnifying means. The micro-characters are printed using flexographic printing.

[0079] The printed layer 2 may contain a rectangular shape. In this case, the area coverage ratio by ink in the ink-coated region of the rectangular shape may be 71% or more. Also, the standard deviation of the line width of the rectangular shape may be 10 or less.

[0080] Examples of rectangular shapes include lines used in barcodes. By keeping the ink coverage area and the standard deviation of the line width within the ink-coated region of the rectangular shape within the above range, the printability of the shape can be improved. Furthermore, if the rectangular shape is included in the barcode, it becomes possible to improve the reading accuracy.

[0081] For non-intaglio printing, either oil-based or water-based inks may be used, but water-based inks are preferred from an environmental perspective. That is, the printing layer 2 may be formed from one or more types selected from oil-based inks and water-based inks. It is particularly preferable that the printing layer 2 contains water-based ink.

[0082] As an example of a water-based ink, one containing a pigment, a binder resin (vehicle), and a solvent (dispersion medium) can be used.

[0083] The pigment may be an inorganic or organic pigment. Examples of inorganic pigments include titanium dioxide (white pigment), carbon black (ink pigment), barium sulfate, calcium carbonate, and other extender pigments. Examples of organic pigments include azo pigments, phthalocyanine pigments, dioxazine pigments, quinacridone pigments, isoindolinone pigments, and underglaze lake pigments.

[0084] The pigment may be one type of pigment or multiple types of pigments. For example, a water-based ink may contain multiple pigments of different colors, or multiple pigments of different particle sizes.

[0085] Furthermore, especially when post-packaging inspection of contents contained in PTP packaging is required, it is preferable that the printed layer does not absorb infrared rays. In that case, carbon black (ink pigment) may not be used as the pigment, and process ink may be used to reproduce the desired appearance. When the printed layer 2 does not absorb infrared rays, better artifact detection accuracy can be obtained. When the printed layer 2 does not absorb infrared rays, it is particularly preferable that the printed layer 2 formed on the lid material 10 reflects 50% or more of near-infrared rays. Moreover, it is even more preferable that the printed layer formed on the lid material reflects 50% or more of near-infrared rays with wavelengths of 800 nm to 900 nm, and particularly preferable that it reflects 65% or more. For this reason, it is desirable to use a pigment that does not absorb infrared rays as the pigment contained in the printed layer 2. In particular, it is preferable that the pigment that does not absorb infrared rays accounts for 70% or more by mass of the total pigment, and especially 80% or more by mass. It is preferable to use one or more pigments selected from disazo yellow, phthalocyanine blue, dioxazine, vilazolo orange, naphthol AS, oxynaphthoic acid, barium salt, soluble azo, perylene black, and aniline black as pigments that do not absorb infrared rays (pigments that transmit infrared rays).

[0086] The pigment content may be 30% to 90% by mass, based on the total mass of the water-based ink. When the pigment content is 30% by mass or more, excellent color development is easily obtained, and the effect of improving the adhesion strength with adjacent layers tends to be significant. When the pigment content is 90% by mass or less, ink peeling tends to be less likely to occur. The pigment content may also be, for example, 35% to 85% by mass, based on the total mass of the water-based ink.

[0087] The binder resin may be, for example, an aqueous binder resin. Examples of aqueous binder resins include water-soluble binder resins, emulsion-type binder resins, and colloidal dispersion-type binder resins.

[0088] Examples of water-based binder resins include natural resins such as casein resin and shellac resin, and synthetic resins such as rosin-modified maleic acid resin, styrene-maleic acid resin, styrene-acrylic acid resin, α-methylstyrene-acrylic acid resin, styrene-methacrylic acid resin, styrene-maleic acid-acrylic acid resin, acrylic acid-acrylic acid ester resin, acrylic acid-methacrylic acid ester resin, acrylic resin, urethane resin, acrylic-urethane resin, styrene resin, polyester resin, as well as water-soluble polyamide resin and water-soluble polyurethane resin. From the viewpoint of obtaining a more significant improvement in adhesive strength, the water-based binder resin may be a resin that does not have a urethane skeleton. As for water-soluble binder resins, from the viewpoint of improving the dispersion stability of inks, the adhesion of water-based inks, and the strength of water-based inks, a resin with no acid value or a low acid value may be used as the main component, and a resin with a high acid value may be used in combination with such a resin.

[0089] The content of the water-based binder resin may be, for example, 15% to 60% by mass, 25% to 55% by mass, or 30% to 50% by mass, based on the total mass of the water-based ink. If the water-based ink is a water-based colorless ink layer, the content of the water-based binder resin may be, for example, 60% to 100% by mass, or 80% to 100% by mass, based on the total mass of the water-based ink.

[0090] The solvent (dispersion medium) of the water-based ink can dissolve or disperse the binder resin in the water-based ink. The solvent (dispersion medium) of the water-based ink may be, for example, water or a hydrophilic solvent. Examples of hydrophilic solvents include alcohol-based solvents such as methanol, ethanol, propanol, and butanol. Some of the solvent (dispersion medium) of the water-based ink may remain in the water-based ink, but the content of the solvent (dispersion medium) may be, for example, 1% by mass or less based on the total mass of the water-based ink.

[0091] Water-based inks may contain one or more auxiliary agents selected from dispersants, plasticizers, waxes, lubricants, defoamers, etc. Examples of plasticizers include dioctyl terephthalate. Examples of waxes include polyethylene and polypropylene. Examples of lubricants include calcium carbonate, barium sulfate, and clay. Examples of defoamers include silicone-based and hydrocarbon-based agents.

[0092] Water-based inks may contain basic compounds, such as ammonia, trimethylamine, sodium hydroxide, or potassium hydroxide, to improve the solubility and dispersibility of the resin in the solvent.

[0093] The lid material 10 may have only one printed layer 2, or it may have two or more printed layers 2. Therefore, the lid material 10 may have a second printed layer 21 as needed. The second printed layer 21 may have different information than that of the printed layer 2. The second printed layer 21 may be provided, for example, on the side of the fragile substrate 1 opposite to the side on which the printed layer 2 is provided. The second printed layer 21 may be provided on the fragile substrate 1, or on the sealant layer 3. Furthermore, the second printed layer 21 may be provided on the vapor deposition layer 4a or the overcoat layer 4b, which will be described later.

[0094] The second printing layer 21 can be formed using non-intaglio printing, similar to the printing layer 2. The same ink as that used for the printing layer 2 can also be used.

[0095] The thickness of the second printing layer is preferably in the range of 0.1 μm to 5 μm. A thickness of 5 μm or less can particularly improve the push-through properties.

[0096] (3-1-4) When a fragile substrate containing a resin film is used for the gas barrier layer lid material 10, it is more permeable to oxygen and water vapor than conventional aluminum foil, which may accelerate the deterioration of the contents depending on the material.

[0097] Therefore, the lid material 10 may have a gas barrier layer 4. By having a gas barrier layer 4 in the lid material 10, the gas barrier properties of the lid material 10 can be enhanced, and the preservation of the solid contents 130 contained in the contents-containing recess 110 can be improved.

[0098] Specifically, by having a gas barrier layer 4 in the lid material 10, it is possible to impart oxygen barrier properties and water vapor barrier properties to the lid material 10.

[0099] An example of a gas barrier layer 4 is a vapor-deposited layer 4a provided on the fragile substrate 1. That is, the lid material 10 of the PTP packaging 100 in this embodiment may have a vapor-deposited layer 4a on the fragile substrate 1. Examples of vapor-deposited layers 4a include metal vapor-deposited films and inorganic vapor-deposited films provided by vapor deposition methods such as physical vapor deposition and chemical vapor deposition.

[0100] Examples of metal vapor-deposited films include those made of aluminum, copper, and iron. Examples of inorganic vapor-deposited films include those made of silicon dioxide and aluminum oxide.

[0101] The thickness of the deposited layer 4a is not particularly limited, but may be, for example, 5 nm to 100 nm, and more preferably 30 nm to 80 nm.

[0102] By making the thickness of the vapor-deposited layer 4a 5 nm or more, sufficient barrier properties are more easily achieved, and by making the thickness of the vapor-deposited layer 4a 100 nm or less, crack formation is prevented and deterioration of barrier properties due to cracks is reduced.

[0103] Furthermore, the surface on which the vapor-deposited layer 4a of the fragile substrate 1 is formed may be subjected to plasma treatment or the like. An anchor layer or the like may also be provided.

[0104] In addition to the vapor deposition layer 4a, the gas barrier layer 4 may have an overcoat layer 4b. The overcoat layer 4b may be further provided on the vapor deposition layer 4a. As the overcoat layer 4b, a layer formed by applying a metal alkoxide, heating and drying it, and curing the metal alkoxide can be used. In addition to the metal alkoxide, a water-soluble resin or a silane coupling agent may be mixed, applied, and cured. As the metal alkoxide, a compound represented by the general formula M(OR) ｎ (where M is a metal atom such as Si, Al, Ti, Zr, etc., R is an alkyl group such as CH ３ or C ２ H ５ etc., and n is the oxidation number of the metal element) can be used. Among them, a metal alkoxide in which the metal atom M is any one of Si, Al, and Ti is preferable.

[0105] As the metal alkoxide, for example, tetraethyl orthosilicate (chemical formula: Si(OC ２ H ５ ) ４ ), triisopropylaluminum (chemical formula: Al(OC ３ H ７ ) ３ ) etc. may be used. As the water-soluble resin, polyvinyl alcohol may be used. The silane coupling agent may have a functional group such as a vinyl group, an epoxy group, a styryl group, a methacryl group, an amino group, a ureido group, a mercapto group, a sulfide group, an isocyanate group, etc.

[0106] The overcoat layer 4b can be formed by coating methods such as roll coating, gravure roll coating, kiss coating, and others, and printing methods such as gravure printing, offset printing, transfer printing, and others.

[0107] The thickness of the overcoat layer 4b is not particularly limited, as the optimal conditions vary depending on the type of coating agent, processing machine, and processing conditions. The thickness of the overcoat layer 4b after drying may be 0.01 μm or more. By making the thickness of the overcoat layer 4b after drying 0.01 μm or more, the uniformity of the coating film can be improved and high gas barrier properties can be obtained. Also, by making the thickness of the overcoat layer 4b 50 μm or less, it is possible to prevent cracks from occurring in the film of the overcoat layer 4b. The thickness of the overcoat layer 4b is preferably in the range of 0.01 μm to 50 μm, and more preferably in the range of 0.1 μm to 10 μm. (3-1-5) Substrate reinforcement layer The lid material 10 of the PTP packaging body 100 in this embodiment may have a vapor-deposited layer 4a as a gas barrier layer 4 on the fragile substrate 1. When forming the vapor-deposited layer 4a, the line speed is generally faster than printing, and the load on the film such as the fragile substrate 1 during transport is large.

[0108] In this embodiment, the lid material 10 of the PTP packaging 100 uses a fragile base material 1 to improve push-through properties. The fragile base material 1 has lower strength than ordinary plastic film base materials, and the film may break or deform during vapor deposition processing.

[0109] Therefore, the lid material 10 of the PTP packaging 100 in this embodiment may have a base material reinforcing layer 1b on the fragile base material 1. Having a base material reinforcing layer 1b on the lid material 10 reduces the load on the fragile base material 1 during film transport when manufacturing the lid material 10 or the PTP packaging 100, making it possible to prevent breakage and deformation of the fragile base material 1.

[0110] The base material reinforcement layer 1b is not particularly limited as long as it can improve push-through properties while preventing breakage and deformation of the fragile base material 1 during film transport, but a resin-coated layer can be used.

[0111] Polyurethane-based resins can be used as such resins. If a coated resin is used instead of a film, the push-through properties of the lid material 10 can be improved, and it will also have better resistance to breakage and deformation under stress than the fragile substrate 1, preventing breakage and deformation of the adjacent fragile substrate.

[0112] The thickness of the base material reinforcement layer 1b is preferably in the range of 0.1 μm to 1 μm. By making the thickness of the base material reinforcement layer 1b 0.1 μm or more, the fracture and deformation of the fragile base material 1 can be particularly prevented. By making the thickness of the base material reinforcement layer 1b 1 μm or less, the push-through properties of the lid material 10 can be particularly improved.

[0113] Furthermore, for the purpose of preventing fracture of the fragile substrate 1, the substrate reinforcement layer 1b may be provided on either side of the fragile substrate 1. However, since it is particularly important to prevent deformation and damage to the side of the fragile substrate 1 on which the vapor-deposited layer 4a is provided, it is preferable to provide the substrate reinforcement layer 1b on the side of the fragile substrate 1 on which the vapor-deposited layer 4a is provided.

[0114] The substrate reinforcement layer 1b can be provided by coating using gravure, microgravure, reverse gravure, die coating, etc.

[0115] Furthermore, using the substrate reinforcement layer 1b provides greater resistance to water vapor permeation after stretching compared to configurations without it. This effect is particularly pronounced when using the substrate reinforcement layer 1b up to 2% stretching.

[0116] As shown in Figure 11, the PTP packaging 100 of this embodiment may have a perforation line 120 located between adjacent content-containing recesses 110. The perforation line allows the PTP packaging 100 to be cut by folding it at the position of the perforation line 120. For this reason, the perforation line 120 may penetrate both the container body 20 and the lid material 10. It is desirable that the perforation line 120 be provided in the form of a dashed line or perforation so that the container body 20 and the lid material 10 do not separate.

[0117] The cut line 120 may separate one of the content-containing recesses 110 from the other content-containing recesses 110. In this case, the PTP packaging 100 is cut by folding it, and a single content-containing recess 110 is separated from the other content-containing recesses 110. For this reason, it is desirable that the cut line 120 be provided in a straight line that crosses the PTP packaging 100 and extends from one end to the other.

[0118] Furthermore, the notches 120 may be used to separate a group of contents-containing recesses 110 into a single group, and to demarcate this group from the other contents-containing recesses 110. For example, notches can be provided to demarcate contents-containing recesses 110 belonging to the same row as a single group. In this way, contents-containing recesses 110 belonging to the same row can be separated from the other contents-containing recesses 110.

[0119] The press-through pack packaging 100 may be sealed by bonding the heat-sealing layer side of the lid material 10 to cover the content-containing recesses 110 of the container body 20, which is formed by deep drawing a soft plastic sheet, and then heat-sealing it.

[0120] In addition, the actual product can be sealed after the solid contents 130 are placed in the contents-retaining recess 110. (3-2) Examples of the arrangement of each layer of the lid material The lid material 10 may have a fragile base material 1, a printed layer 2, and a sealant layer 3 as described above.

[0121] The lid material 10 may further have an optional layer, such as a gas barrier layer 4 or a base material reinforcing layer 1b, as needed.

[0122] The lid material 10 may include multiple printed layers 2, and may also have a second printed layer 21 as an optional layer.

[0123] The gas barrier layer 4 may include a vapor-deposited layer 4a, or it may include a vapor-deposited layer 4a and an overcoat layer 4b. When the gas barrier layer 4 includes a vapor-deposited layer 4a and an overcoat layer 4b, the stacking order of the vapor-deposited layer 4a and the overcoat layer 4b is not particularly limited, and either layer may be placed in a position close to the surface 10A of the lid material 10.

[0124] The following will explain examples of the stacking arrangement of each layer using Figures 1 to 10. Figures 1 to 10 are cross-sectional views of the lid material 10, and are cross-sectional views of the lid material 10 along the stacking direction of each layer.

[0125] As shown in Figure 1, the lid material 10 may have a sealant layer 3 on the first surface 1A of the fragile substrate 1 and a printed layer 2 on the second surface 1B. In the lid material 10 shown in Figure 1, the sealant layer 3, fragile substrate 1, and printed layer 2 are laminated in order from the position closest to the surface 10A of the lid material 10.

[0126] As shown in Figure 2, the lid material 10 may have a second printed layer 21 on top of the sealant layer 3. In the lid material 10 shown in Figure 2, the second printed layer 21, sealant layer 3, fragile substrate 1, and printed layer 2 are laminated in order from a position close to the surface 10A of the lid material 10. The printed layer 2 can also be called the first printed layer to distinguish it from the second printed layer 21.

[0127] As shown in Figure 3, the lid material 10 may further have a gas barrier layer 4. In the lid material 10 shown in Figure 3, the second printing layer 21, sealant layer 3, overcoat layer 4b, vapor deposition layer 4a, fragile substrate 1, and printing layer 2 are laminated in order from a position close to the surface 10A of the lid material 10. The vapor deposition layer 4a and the overcoat layer 4b form the gas barrier layer 4. The gas barrier layer 4 may be formed from the vapor deposition layer 4a alone.

[0128] The arrangement of the second printing layer 21 is not limited to that shown in Figure 3. As shown in Figure 4, the lid material 10 may be constructed by laminating the sealant layer 3, the second printing layer 21, the overcoat layer 4b, the vapor-deposited layer 4a, the fragile substrate 1, and the printing layer 2 in order from a position close to the surface 10A of the lid material 10. The vapor-deposited layer 4a and the overcoat layer 4b form the gas barrier layer 4. The gas barrier layer 4 may be formed from the vapor-deposited layer 4a alone.

[0129] The arrangement of the gas barrier layer 4 and the second printing layer 21 is not limited to those shown in Figures 3 and 4. In the lid material 10 shown in Figure 5, the sealant layer 3, printing layer 2, fragile substrate 1, vapor deposition layer 4a, overcoat layer 4b, and second printing layer 21 are laminated in order from the position closest to the surface 10A of the lid material 10.

[0130] As shown in Figure 6, the gas barrier layer 4 may be formed from only the vapor-deposited layer 4a. In the lid material 10 shown in Figure 6, a sealant layer 3, a vapor-deposited layer 4a, a fragile substrate 1, and a printed layer 2 are laminated in order from a position close to the surface 10A of the lid material 10. The vapor-deposited layer 4a becomes the gas barrier layer 4.

[0131] As shown in Figure 7, the lid material 10 may further have a substrate reinforcing layer 1b. In the lid material 10 shown in Figure 7, a sealant layer 3, a vapor-deposited layer 4a, a substrate reinforcing layer 1b, a fragile substrate 1, and a printed layer 2 are laminated in order from a position close to the surface 10A of the lid material 10. The vapor-deposited layer 4a becomes the gas barrier layer 4.

[0132] The lid material 10 shown in Figure 8 has the following layers stacked in order from the position closest to the surface 10A of the lid material 10: second printing layer 21, sealant layer 3, overcoat layer 4b, vapor deposition layer 4a, substrate reinforcement layer 1b, fragile substrate 1, and printing layer 2. The vapor deposition layer 4a and overcoat layer 4b form the gas barrier layer 4.

[0133] The lid material 10 shown in Figure 9 has the following layers stacked in order from the position closest to the surface 10A of the lid material 10: sealant layer 3, second printing layer 21, overcoat layer 4b, vapor deposition layer 4a, substrate reinforcement layer 1b, fragile substrate 1, and printing layer 2. The vapor deposition layer 4a and overcoat layer 4b form the gas barrier layer 4.

[0134] The lid material 10 shown in Figure 10 has the following layers stacked in order from the position closest to the surface 10A of the lid material 10: sealant layer 3, printing layer 2, fragile substrate 1, substrate reinforcement layer 1b, vapor deposition layer 4a, overcoat layer 4b, and second printing layer 21. The vapor deposition layer 4a and overcoat layer 4b form the gas barrier layer 4.

[0135] Figures 1 to 10 show examples of the arrangement of layers in the lid material 10, and are not limited to these forms; any arrangement is possible.

[0136] The following describes this embodiment with reference to specific examples and comparative examples, but this embodiment is not limited to these.

[0137] (1) Experimental Example 1 [Example 1-1] A lid material having the cross-sectional structure shown in Figure 1 was prepared to be used as a lid material for press-through pack packaging. Specifically, a lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the Push-Through Performance Evaluation.

[0138] As the fragile substrate 1, a polypropylene resin (PP) substrate having the characteristics shown in Table 2 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation was used. Therefore, the fragile substrate 1 includes a resin film. The methods for measuring puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation have already been explained, so the explanation is omitted here.

[0139] The printed layer 2 was formed on the second surface 1B, which is one side of the fragile substrate 1, by flexographic printing using an aqueous ink. The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the thickness of the resulting printed layer 2 was 0.5 μm.

[0140] Furthermore, the printed layer 2 was printed with the grid pattern shown in Figure 13 and the barcode shown in Figure 14. Therefore, the printed layer 2 is a layer in which water-based ink is placed on a part of the second surface 1B of the fragile substrate 1.

[0141] The sealant layer 3 was formed using gravure coating on the entire first surface 1A of the fragile substrate 1, using a product manufactured by Mitsui Chemicals, Inc., product name: Unistoll XP01B.

[0142] [Example 1-2] As the fragile substrate 1, a polypropylene resin (PP) substrate having the characteristics shown in Table 2 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation was used. Therefore, the fragile substrate 1 includes a resin film. Except for changing the fragile substrate to the above substrate, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 1-1.

[0143] [Example 1-3] The printed layer 2 to be provided on the second surface 1B of the fragile substrate 1 was formed by EB offset printing. Except for the above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 1-1.

[0144] The ink used to form the printed layer 2 was an ink containing a thermoplastic resin containing a copolymer of ethylene acrylic acid and ethylene methacrylic acid. After printing using a dampening solution in a water-based offset printing press (COMEXI, CI-8), the ink layer was irradiated with an electron beam (EB) at a dose of 30 kGy from the ink layer side under a nitrogen atmosphere using an electron beam irradiation device (Iwasaki Electric Co., Ltd., EC series). The thickness of the printed layer 2 was 1.5 μm. [Example 1-4] The printed layer 2 to be provided on the second surface 1B was formed by an inkjet printing method. Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 1-1.

[0145] For inkjet printing, a medium (transparent) ink was applied to the second surface 1B of the fragile substrate 1 using a gravure coating method to create an ink-receiving layer. Then, an inkjet ink, in which pigment was dispersed in a dispersant consisting of water-based resin varnish and water, was used on the ink-receiving layer, and printing was performed using an inkjet printer. The thickness of the printed layer 2 was 1.5 μm.

[0146] [Examples 1-5] As the fragile substrate 1, a white substrate containing titanium dioxide was used, and the thickness, maximum height of unevenness, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation were the characteristics shown in Table 2, which were polypropylene resin (PP) substrates.

[0147] Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 1-1.

[0148] [Comparative Example 1-1] A lid material having the cross-sectional structure shown in Figure 1 was prepared as a lid material for use in a press-through pack packaging. Specifically, the lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0149] As the fragile substrate 1, a polypropylene resin (PP) substrate having the characteristics shown in Table 2 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation was used. Therefore, the fragile substrate 1 includes a resin film.

[0150] The printed layer 2 was formed on the second surface 1B, which is one side of the fragile substrate 1, by gravure printing using an oil-based ink. The ink used was FB King, manufactured by Toyo Ink Co., Ltd., and the thickness of the resulting printed layer 2 was 0.5 μm.

[0151] Furthermore, the printed layer 2 was printed with the grid pattern shown in Figure 13 and the barcode shown in Figure 14. Therefore, the printed layer 2 is a layer in which water-based ink is placed on a part of the second surface 1B of the fragile substrate 1.

[0152] The sealant layer 3 was formed using Unistoll XP01B, manufactured by Mitsui Chemicals, Inc., and applied to the entire first surface 1A of the fragile substrate 1 by gravure coating.

[0153] Therefore, Comparative Example 1-1 manufactures the lid material under the same conditions as Example 1-1, except that gravure printing is performed using oil-based ink when forming the printed layer 2. <Evaluation> The evaluation results are shown below.

[0154] (Print Evaluation) The lid materials of Examples 1-1 to 1-5 and Comparative Example 1-1 were printed with a grid pattern or barcode as shown in Figures 13 and 14, and three locations within the printed pattern that were printed in a single color of straight lines were selected. Specifically, for the grid pattern shown in Figure 13, printed line 131 in field of view a was selected, for the barcode lines shown in Figure 14, printed line 141 in field of view b was selected, and for the frame lines surrounding the barcode, printed line 142 in field of view c was selected. The printed lines in fields of view a, b, and c were then observed using a Hirox microscope (DIGITAL MICROSCOPE KH-8700). For observation, the field of view was adjusted so that the target printed line was positioned in the center of the field of view at a magnification of 200x. Then, as shown in Figure 15, the line widths L151, L152, L153, ​​L154, and L155 were measured at five arbitrary points for each of the printed lines 131, 141, and 142 (n = 1 to 5).

[0155] In each of the fields a, b, and c, line widths L151 to L155 were measured at five arbitrary locations, and the standard deviation was calculated. In Examples 1-2 to 1-5 and Comparative Example 1-1, measurements were taken only in field a, and the standard deviation was calculated.

[0156] The measurements were taken three times on the same type of printed line, each time at a different position in the field of view. In Table 1, the first, second, and third measurements refer to measurements taken at different positions in the field of view, and the standard deviation was calculated for each measurement, thus yielding standard deviations (a) to (c). For example, in the case of field of view a, observations and measurements were performed three times at different positions on the same printed line 131, and the standard deviation was calculated for each measurement.

[0157] Furthermore, the bottom row of Table 1 shows the standard deviation for a total of 15 measurements taken by changing the field of view, allowing us to check the variability of the printed lines.

[0158] Note that the sample standard deviation is used to calculate the standard deviation.

[0159] (Push-through performance evaluation) A container body 20 was formed by compressing a 300 μm thick CPP sheet to create multiple content-containing recesses 110. Each of the multiple content-containing recesses 110 of the container body 20 was filled with a solid content 130, consisting of a flat tablet-like drug measuring 2 mm thick and 8 mm in diameter. The entire first surface 20A of the container body 20 was then sealed with the lid material prepared in each example and comparative example, closing the openings 110A of the content-containing recesses 110 to form a press-through pack package.

[0160] The lid material 10 was positioned so that its surface 10A faced the container body 20 and its back surface 10B was exposed to the outside, and then sealed.

[0161] The obtained PTP packaging was subjected to an attempt to remove the solid contents 130 by pressing the bottom 110B of the content-containing recess 110 with a finger. The test was conducted by the same tester, and under the same conditions, if the solid contents 130, which are a tablet-like drug, could be removed with a force that was not impractical, it was evaluated as having excellent push-through properties (○). If the solid contents 130 could not be removed or was difficult to remove, it was evaluated as having poor push-through properties (×). <Evaluation Results> The results of the above evaluation are shown in Table 1.

[0162] Table 1 shows that in Examples 1-1 to 1-5, which used non-intaglio printing, the standard deviation of the print line width variation was small, at 10.00 or less in all cases. In particular, in Examples 1-1, 1-2, and 1-5, which used flexographic printing, the standard deviation of the print line width variation was small, at 9.00 or less in all cases. Among these, in Example 1-1, the standard deviation of the print line width variation at three locations (field a, field b, and field c) was small, at 5.00 or less in all cases, and in Example 1-5, the standard deviation of the print line width variation at field a was also small, at 5.00 or less in all cases.

[0163] In contrast, in Comparative Example 1-1, which used gravure printing, an intaglio printing method, to form the printed layer, the overall standard deviation was 14.93, confirming that the variation in printed line width was large.

[0164] Furthermore, it was confirmed that all PTP packaging materials manufactured in Examples 1-1 to 1-4 exhibited excellent push-through properties.

[0165]

[0166]

[0167] According to the evaluation results, the printed patterns on the lid materials of Examples 1-1 to 1-5, in which the printed layer was formed by non-intaglio printing, showed little variation in line width in all areas, resulting in clear patterns. On the other hand, the printed patterns on the lid material of Comparative Example 1-1, in which the printed layer was formed by gravure printing, an intaglio printing method, showed large variation, resulting in unclear characters. (2) Experimental Example 2 [Examples 2-1 to 2-4] A lid material having the cross-sectional structure shown in Figure 1 was prepared as a lid material to be used for press-through pack packaging. That is, a lid material was manufactured having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0168] In each embodiment, the fragile substrate 1 used was a polypropylene resin (PP) substrate having the characteristics shown in Table 7 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation. Therefore, the fragile substrate 1 includes a resin film.

[0169] The printed layer 2 was formed on the second surface 1B, which is one side of the fragile substrate 1, by flexographic printing using an aqueous ink. The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the thickness of the resulting printed layer 2 was 0.5 μm.

[0170] When performing flexographic printing, the screen count of the anilox transfer plate was set to either fine, medium, or coarse. When performing flexographic printing, the barcode bar and the frame surrounding it will be black, and the white area surrounding the black area will be included. The screen count of the anilox was changed for the black area and the white area. In Table 4, the type of anilox used when printing the black area is shown in the "Black" column of the "Printing Layer Formation Conditions" section, and the type of anilox used when printing the white area is shown in the "White" column. The ink layering pattern is also shown in the "Ink Layering Pattern" column of Table 4. In the "Ink Layering Pattern" column, "Substrate" refers to a fragile substrate. Therefore, in the case of Example 2-1, it means that a printing layer containing one white layer and one black layer was formed on fragile substrate 1. In the case of Example 2-3, it means that a printing layer containing two white layers and one black (extra black) layer was formed on fragile substrate. In Example 2-4, a white layer is also formed on the first surface 1A of the fragile substrate 1, meaning that there are two white layers in total. "Special Black" refers to an ink that is a mixture of multiple colors.

[0171] Furthermore, the barcode shown in Figure 14 was printed on the printed layer 2. Therefore, the printed layer 2 is a layer in which water-based ink is placed on a part of the second surface 1B of the fragile substrate 1.

[0172] The sealant layer 3 was made using Unistoll XP01B, manufactured by Mitsui Chemicals, Inc., and formed by gravure coating over the entire first surface 1A of the fragile substrate 1.

[0173] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Table 4. [Examples 2-5 to 2-8] In each example, the fragile base material 1 was a polypropylene resin (PP) base material having the characteristics shown in Table 7 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation. Therefore, the fragile base material 1 includes a resin film. The lid material and press-through pack packaging were manufactured under the same conditions as in Example 2-1, except that the fragile base material was changed to the above base material.

[0174] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Tables 4 and 5. [Examples 2-9 to 2-11] In each example, the fragile substrate 1 was a polypropylene resin (PP) substrate having the characteristics shown in Table 7 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation. Therefore, the fragile substrate 1 includes a resin film.

[0175] In Examples 2-9 to 2-11, the printed layer was created by flexographic printing, and the anilox screen count and ink layering pattern were set to the conditions shown in Table 5.

[0176] Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 2-1.

[0177] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Table 5. [Comparative Example 2-1] In Comparative Example 2-1, the printed layer was formed by gravure printing. Tokyo Ink NT-VESTA was used as the ink, and the thickness of the obtained printed layer was 1.0 μm.

[0178] Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 2-1.

[0179] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Table 6. [Comparative Example 2-2] Instead of the fragile base material 1, a polyethylene terephthalate resin (PET) base material having the characteristics shown in Table 7 for thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation was used as the base material.

[0180] In Comparative Example 2-2, the printed layer was formed by flexographic printing, and the anilox screen ruling and the conditions for forming the printed layer were as shown in Table 6.

[0181] Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 2-1.

[0182] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Table 6. [Comparative Example 2-3] Instead of the fragile base material 1, an unoriented polypropylene (CPP) base material having the thickness, maximum unevenness height, puncture strength, MD tensile strength, TD tensile strength, MD tensile elongation, and TD tensile elongation shown in Table 7 was used as the base material.

[0183] In Comparative Example 2-3, the printed layer was formed by flexographic printing, and the anilox screen count and the conditions for forming the printed layer were as shown in Table 6.

[0184] Except for the points mentioned above, the lid material and press-through pack packaging were manufactured under the same conditions as in Example 2-1.

[0185] The obtained lid material and PTP packaging were evaluated as described below. The evaluation results are shown in Table 6. <Evaluation> The evaluation method is shown below.

[0186] (Barcode reading evaluation) A barcode with a module width of 0.254 mm was read using a microscan LVS-9510 barcode verification machine, and the evaluation was performed based on the four judgment items shown in Table 3.

[0187] The evaluation of each evaluation item was conducted in accordance with ISO / IEC 15416:2016.

[0188] An evaluation item was considered a pass if it received a score of 1.5 or higher, and a fail if it received a score of less than 1.5. A pass in all four items indicated excellent barcode reading performance, while a fail in any one item indicated poor barcode reading performance.

[0189] (Print Evaluation) A barcode was printed on the lid material as shown in Figure 14, and the printed line 141 in field of view b was selected from the barcode lines shown in Figure 14. The printed line in field of view b was then observed using a Hirox microscope (DIGITAL MICROSCOPE KH-8700). For the observation, the field of view was adjusted so that the target printed line was positioned in the center of the field of view at a magnification of 200x. Then, as shown in Figure 15, the line widths L151, L152, L153, ​​L154, and L155 of the printed line 141 were measured at five arbitrary points (n=1 to 5).

[0190] The standard deviation was calculated for line widths L151 to L155 measured at five arbitrary locations.

[0191] The measurements were taken three times for the same type of printed line, each time at a different field of view. In Table 2, "1st," "2nd," and "3rd" refer to the measurements taken at different field of view positions, and the standard deviation was calculated for each measurement.

[0192] Note that the sample standard deviation is used to calculate the standard deviation.

[0193] (Area occupancy rate by ink) For the rectangular bar with the largest area among the printed barcode bars, the image processing software ImageJ was used to binarize it, and the area percentage of the barcode ink-coated portion of the evaluated barcode bar was calculated.

[0194] (Push-through performance evaluation) A container body 20 was formed by compressing a 300 μm thick CPP sheet to create multiple content-containing recesses 110. Each of the multiple content-containing recesses 110 of the container body 20 was filled with a solid content 130, consisting of a flat tablet-like drug measuring 2 mm thick and 8 mm in diameter. The entire first surface 20A of the container body 20 was then sealed with the lid material prepared in each example and comparative example, closing the openings 110A of the content-containing recesses 110 to form a press-through pack package.

[0195] The lid material 10 was positioned so that its surface 10A faced the container body 20 and its back surface 10B was exposed to the outside, and then sealed.

[0196] The obtained PTP packaging was subjected to an attempt to remove the solid contents 130 by pressing the bottom 110B of the content-containing recess 110 with a finger. The test was conducted by the same tester, and under the same conditions, if the solid contents 130, which are a tablet-like drug, could be removed with a force that was not practically problematic, it was evaluated as having excellent push-through properties (○). If the solid contents 130 could not be removed or was difficult to remove, it was evaluated as having poor push-through properties (×).

[0197]

[0198]

[0199]

[0200] (3) Experimental Example 3 (3-1) Example 3-1 A lid material 10 to be used for the press-through pack packaging 100 was prepared, having the cross-sectional structure shown in Figure 6. Specifically, the lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a vapor-deposited layer 4a, which is a gas barrier layer 4, and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the Push-Through Performance Evaluation.

[0201] The fragile substrate 1 uses a polypropylene resin (PP) substrate having the properties shown in Table 9, and includes a resin film.

[0202] The vapor-deposited layer 4a was formed with silica to a thickness of 30 nm by vacuum deposition. Sample 1A was produced with a line speed of 5 m / sec, and Sample 1B was produced with a line speed of 10 m / sec.

[0203] The printed layer 2 was formed on the second surface 1B, which is one side of the fragile substrate 1, by flexographic printing using water-based ink.

[0204] The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the resulting printed layer had a thickness of 0.5 μm.

[0205] The sealant layer 3 was formed using gravure coating with Unistol XP01B, manufactured by Mitsui Chemicals, Inc.

[0206] The evaluation results are shown in Table 8.

[0207] (3-2) Example 3-2 A lid material 10 to be used for the press-through pack packaging 100 was prepared, having the cross-sectional structure shown in Figure 7. Specifically, the lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a base material reinforcing layer 1b, a vapor-deposited layer 4a which is a gas barrier layer 4, and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0208] The fragile substrate 1, printed layer 2, and sealant layer 3 were the same as those used in Example 3-1 and formed under the same conditions.

[0209] The substrate reinforcement layer 1b used Dianaal, an acrylic coating agent manufactured by Mitsubishi Chemical Corporation.

[0210] The vapor-deposited layer 4a was formed with silica to a thickness of 30 nm by vacuum deposition. Sample 2A was produced with a line speed of 5 m / sec, and sample 2B was produced with a line speed of 10 m / sec.

[0211] The evaluation results are shown in Table 8. (3-3) Example 3-3 A lid material 10 to be used for the press-through pack packaging 100 was prepared, having the cross-sectional structure shown in Figure 8. Specifically, the lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a base material reinforcing layer 1b, a vapor-deposited layer 4a and an overcoat layer 4b which are gas barrier layers 4, a sealant layer 3 and a second printed layer 21 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0212] The fragile substrate 1, printed layer 2, and sealant layer 3 were the same as those used in Example 3-1 and formed under the same conditions.

[0213] The substrate reinforcement layer 1b was formed using UC Sealer, an acrylic coating agent manufactured by DIC Corporation.

[0214] The vapor-deposited layer 4a was formed with silica to a thickness of 30 nm by vacuum deposition. Sample 3A was produced with a line speed of 5 m / sec, and sample 3B was produced with a line speed of 10 m / sec.

[0215] The overcoat layer 4b was formed by coating and drying a solution obtained by mixing Solution I and Solution II shown below in a ratio (wt%) of 60 / 40 using the gravure coating method, to a thickness of 0.3 μm. <Solution I> 10.4 g of tetraethoxysilane was mixed with 89.6 g of hydrochloric acid (0.1 N) and stirred for 30 minutes to hydrolyze it, and SiO ２ A hydrolysis solution with a solid content of 3 wt% was prepared. <Solution II> A 97% by weight water-isopropyl alcohol solution, prepared by mixing water and isopropyl alcohol in a weight ratio of 90:10, was mixed with 3% by weight polyvinyl alcohol.

[0216] The second printed layer 21 was formed on the sealant layer 3 by flexographic printing using water-based ink.

[0217] The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the resulting printed layer had a thickness of 0.5 μm.

[0218] The evaluation results are shown in Table 8. (3-4) Example 3-4 A lid material 10 to be used for the press-through pack packaging 100 was prepared, having the cross-sectional structure shown in Figure 9. Specifically, the lid material was made having a printed layer 2 on the second surface 1B, which is one side of the fragile base material 1, and a base material reinforcing layer 1b, a vapor-deposited layer 4a and an overcoat layer 4b which are gas barrier layers 4, a second printed layer 21 and a sealant layer 3 on the first surface 1A, which is the side opposite to the printed layer 2. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0219] The fragile substrate 1, printed layer 2, and sealant layer 3 were the same as those used in Example 3-1 and formed under the same conditions.

[0220] The substrate reinforcement layer 1b was formed using a PVB-based coating agent manufactured by Matsumoto Fine Chemical Co., Ltd., under the trade name Orgatics.

[0221] The vapor-deposited layer 4a was formed with silica to a thickness of 30 nm by vacuum deposition. The line speed was 5 m / sec (sample 4A) and 10 m / sec (sample 4B).

[0222] The overcoat layer was formed under the same conditions and procedure as in Example 3-3.

[0223] The second printed layer 21 was then formed on the overcoat layer 4b by flexographic printing using water-based ink.

[0224] The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the thickness of the resulting second printed layer 21 was 0.5 μm.

[0225] The evaluation results are shown in Table 8. (3-5) Example 3-5 A lid material 10 to be used for the press-through pack packaging 100 was prepared, having the cross-sectional structure shown in Figure 10. Specifically, as the lid material, a substrate reinforcement layer 1b, a vapor-deposited layer 4a and an overcoat layer 4b which are gas barrier layers 4, and a second printing layer 21 were laminated in that order on the second surface 1B, which is one side of the fragile substrate 1. In addition, a printing layer 2 and a sealant layer 3 were laminated on the first surface 1A of the fragile substrate 1. Furthermore, a press-through pack packaging was manufactured using the lid material under the conditions and procedures described in the push-through performance evaluation.

[0226] The fragile substrate 1, printed layer 2, and sealant layer 3 were the same as those used in Example 3-1 and formed under the same conditions.

[0227] The substrate reinforcement layer 1b was formed using Gosenex, a PVOH agent manufactured by Nippon Synthetic Chemical Co., Ltd.

[0228] The vapor-deposited layer 4a was formed by vacuum deposition of silica to a thickness of 30 nm. The line speed was 5 m / sec (sample 5A) and 10 m / sec (sample 5B).

[0229] The overcoat layer 4b was formed under the same conditions and procedure as in Example 3-3.

[0230] The second printed layer 21 was then formed on the overcoat layer 4b by flexographic printing using water-based ink.

[0231] The ink used was Aquariona, manufactured by Toyo Ink Co., Ltd., and the thickness of the resulting second printed layer 21 was 0.5 μm.

[0232] The evaluation results are shown in Table 8. (3-6) Examples 3-6 to 3-10 For the vapor-deposited layer 4a, aluminum was vacuum-deposited instead of silica, and the thickness was set to 80 nm. The line speed when forming the vapor-deposited layer was set to 8 m / sec.

[0233] Except for the points mentioned above, the lid material used for press-through pack packaging was manufactured and evaluated under the same conditions as the corresponding examples, Examples 3-1 to 3-5.

[0234] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0235] The evaluation results are shown in Table 8.

[0236] Example 3-6 corresponds to Example 3-1, Example 3-7 to Example 3-2, Example 3-8 to Example 3-3, Example 3-9 to Example 3-4, and Example 3-10 to Example 3-5. (3-7) Examples 3-11 to 3-15 Except for changing the fragile base material 1 to a polypropylene resin (PP) base material having the properties shown in Table 9, lid materials for press-through pack packaging were manufactured and evaluated under the same conditions as the corresponding examples, Examples 3-1 to 3-5.

[0237] The line speed used to form the vapor-deposited layer was set to 10 m / sec.

[0238] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0239] The evaluation results are shown in Table 8.

[0240] Example 3-11 corresponds to Example 3-1, Example 3-12 to Example 3-2, Example 3-13 to Example 3-3, Example 3-14 to Example 3-4, and Example 3-15 to Example 3-5. (3-8) Examples 3-16 to 3-20 Except for changing the fragile base material 1 to a polypropylene resin (PP) base material having the properties shown in Table 9, lid materials for press-through pack packaging were manufactured and evaluated under the same conditions as the corresponding examples, Examples 3-6 to 3-10.

[0241] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0242] The evaluation results are shown in Table 8.

[0243] Example 3-16 corresponds to Example 3-6, Example 3-17 to Example 3-7, Example 3-18 to Example 3-8, Example 3-19 to Example 3-9, and Example 3-20 to Example 3-10.

[0244] (3-9) Example 3-21 A lid material for press-through pack packaging was manufactured and evaluated under the same conditions as in Example 3-1, except that the printed layer 2 provided on the second surface 1B was formed by the EB offset printing method.

[0245] The ink used was a thermoplastic resin containing a copolymer of ethylene acrylic acid and ethylene methacrylic acid. The print was then made using a COMEXI CI-8 offset printing press with dampening solution, followed by irradiation with an electron beam (EB) at a dose of 30 kGy from the ink layer side under a nitrogen atmosphere using an electron beam irradiation device (Iwasaki Electric Co., Ltd. EC series). The thickness of the printed layer 2 was 1.5 μm.

[0246] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0247] The evaluation results are shown in Table 8. (3-10) Example 3-22 A lid material for press-through pack packaging was manufactured and evaluated under the same conditions as in Example 3-1, except that the printed layer 2 provided on the second surface 1B was formed by an inkjet printing method.

[0248] For inkjet printing, a medium (transparent) ink was applied to the second surface 1B of the fragile substrate 1 using a gravure coating method to create an ink-receiving layer. Then, an inkjet ink, in which pigment was dispersed in a dispersant consisting of water-based resin varnish and water, was used on the ink-receiving layer, and printing was performed using an inkjet printer. The thickness of the printed layer 2 was 1.5 μm.

[0249] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0250] The evaluation results are shown in Table 8. (3-11) Example 3-23 A lid material for press-through pack packaging was manufactured and evaluated under the same conditions as in Example 3-11, except that the printed layer 2 provided on the second surface 1B was formed by the EB offset printing method.

[0251] The ink used was a thermoplastic resin containing a copolymer of ethylene acrylic acid and ethylene methacrylic acid. The print was then made using a COMEXI CI-8 offset printing press with dampening solution, followed by irradiation with an electron beam (EB) at a dose of 30 kGy from the ink layer side under a nitrogen atmosphere using an electron beam irradiation device (Iwasaki Electric Co., Ltd. EC series). The thickness of the printed layer 2 was 1.5 μm.

[0252] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0253] The evaluation results are shown in Table 8. (3-12) Example 3-24 A lid material for press-through pack packaging was manufactured and evaluated under the same conditions as in Example 3-11, except that the printed layer 2 provided on the second surface 1B was formed by an inkjet printing method.

[0254] For inkjet printing, a medium (transparent) ink was applied to the second surface 1B of the fragile substrate 1 using a gravure coating method to create an ink-receiving layer. Then, an inkjet ink, in which pigment was dispersed in a dispersant consisting of water-based resin varnish and water, was used on the ink-receiving layer, and printing was performed using an inkjet printer. The thickness of the printed layer 2 was 1.5 μm.

[0255] Furthermore, using the manufactured lid material, press-through pack packaging was produced according to the conditions and procedures described in the push-through performance evaluation.

[0256] The evaluation results are shown in Table 8. <Evaluation> The evaluation method is described below.

[0257] (Oxygen Permeability) The oxygen permeability of the lid material was measured in accordance with the test method of JIS K 7126-2 (2006) using an oxygen permeability tester (OX-TRAN 2 / 20, manufactured by Mokon). The test temperature was 30°C, the test humidity was 70% RH, and the permeation area was 50 cm². ２ The test was conducted using 100% oxygen as the test gas. The oxygen permeability was 1.0 mL / m³. ２ ◎ indicates a reading of 1.0 mL / m² or less per day atm. ２ • Larger than day / atm, at 50 mL / m² ２ ・○ if the daily atm is below 50 mL / m² ２ A score of △ was given if the value was greater than day・atm.

[0258] A rating of ◎ for oxygen permeability indicates the greatest reduction in oxygen permeability, followed by ○ and △, in descending order of oxygen permeability. A rating of ◎ or ○ indicates a lid material with particularly reduced oxygen permeability, or a press-through pack packaging manufactured using such a lid material.

[0259] (Water vapor permeability) The water vapor permeability of the lid material was tested in accordance with the test method of JIS K 7129-2 (2019), with a test temperature of 40°C and a test humidity of 90% RH.

[0260] The water vapor transmission rate is 0.5 g / m³. ２ ◎ if the daily atm is less than or equal to 0.5 g / m². ２ - Larger than 2g / m ２- If the daily rate is less than or equal to 2g / m³, then it is OK. ２ A score of △ was given if the value was greater than day・atm.

[0261] A rating of ◎ for water vapor permeability indicates the greatest reduction in water vapor permeability, followed by ○ and △ in descending order of water vapor permeability. A rating of ◎ or ○ indicates a lid material with particularly reduced water vapor permeability, or a press-through pack packaging manufactured using such a lid material.

[0262] (Overall evaluation) If the evaluation results for oxygen permeability and water vapor permeability were either ◎ and no △, the overall evaluation was set to ◎.

[0263] If both the oxygen permeability and water vapor permeability evaluation results were marked with a circle (○), the overall evaluation was given as a circle (○).

[0264] If either the oxygen permeability or water vapor permeability evaluation result included a △, the overall evaluation was set to △.

[0265] The overall evaluation is a comprehensive assessment of oxygen permeability and water vapor permeability. An evaluation of ◎ means that oxygen permeability and water vapor permeability have been sufficiently reduced, while ◎, ○, and △ indicate increasing oxygen permeability and water vapor permeability, respectively, and indicate inferior performance.

[0266] If the overall evaluation is ◎ or ○, it can be said that oxygen permeability and water vapor permeability have been particularly reduced. (Push-through performance evaluation) A container body 20 was made by forming multiple content-containing recesses 110 on a 300 μm thick CPP sheet by pressure molding. Each of the multiple content-containing recesses 110 of the container body 20 was filled with a flat tablet-like drug with a thickness of 2 mm and a diameter of 8 mm as a solid content 130. The entire first surface 20A of the container body 20 was sealed with the lid material made in each example and comparative example, closing the openings 110A of the content-containing recesses 110 to form a press-through pack package.

[0267] The lid material 10 was positioned so that its surface 10A faced the container body 20 and its back surface 10B was exposed to the outside, and then sealed.

[0268] The obtained PTP packaging was subjected to an attempt to remove the solid contents 130 by pressing the bottom 110B of the content-containing recess 110 with a finger. The test was conducted by the same tester, and under the same conditions, if the solid contents 130, which are a tablet-like drug, could be removed with a force that was not practically problematic, it was evaluated as having excellent push-through properties (○). If the solid contents 130 could not be removed or was difficult to remove, it was evaluated as having poor push-through properties (×).

[0269]

[0270] <Evaluation Results> According to the evaluation results, it was confirmed that the lid materials of Examples 3-1 to 3-24 all possessed particularly good oxygen barrier and water vapor barrier properties. According to the inventors' research, it was confirmed that in all cases, the oxygen permeability was reduced compared to the case without a vapor-deposited film.

[0271] Furthermore, it was confirmed that the lid material in all embodiments exhibited excellent push-through properties.

[0272] The summary of this disclosure is as follows:

[0273] [1] A press-through pack packaging comprising: a container body including a plastic sheet having a plurality of content-containing recesses; solid contents contained in each of the plurality of content-containing recesses; and a lid material that closes the openings of the plurality of content-containing recesses, wherein the lid material comprises a fragile substrate including a resin film, a printed layer disposed on the fragile substrate, and a sealant layer, wherein the printed layer is formed by a printing method other than intaglio printing, or the fragile substrate has a vapor-deposited layer.

[0274] [2] The press-through pack packaging according to [1], wherein the fragile substrate has a maximum unevenness height of 0.5 μm to 9.0 μm.

[0275] [3] The press-through pack packaging according to [1] or [2], wherein the fragile base material has an MD tensile strength of 20 MPa to 50 MPa and a TD tensile strength of 20 MPa to 50 MPa.

[0276] [4] The press-through pack packaging according to any one of [1] to [3], wherein the fragile material has a tensile elongation of 50% or less in both MD and TD.

[0277] [5] The press-through pack packaging according to any one of [1] to [4], wherein the puncture strength of the fragile base material is 8.0 N or less.

[0278] [6] The press-through pack packaging according to any one of [1] to [5], wherein the fragile base material comprises polypropylene.

[0279] [7] The press-through pack packaging according to any one of [1] to [6], wherein the printed layer is formed by flexographic printing.

[0280] [8] The press-through pack packaging according to any one of [1] to [7], wherein the printing layer contains water-based ink.

[0281] [9] The press-through pack packaging according to any one of [1] to [8], wherein the printed layer contains security printing that includes one or more types selected from microcharacters and microfigures.

[0282]

[10] The press-through pack packaging according to any one of [1] to [9], wherein the printed layer includes a rectangular figure, the area occupancy rate by the ink in the area where the ink of the rectangular figure is applied is 71% or more, and the standard deviation of the line width of the rectangular figure is 10 or less.

[0283]

[11] A press-through pack packaging according to any one of [1] to

[10] , comprising a vapor-deposited layer on the fragile substrate.

[0284]

[12] A press-through pack packaging according to any one of [1] to

[11] , having a base material reinforcing layer on the fragile base material.

[0285] This application claims priority based on Japanese Patent Application No. 2024-166651, filed with the Japan Patent Office on 25 September 2024, and Japanese Patent Application No. 2024-186588, filed with the Japan Patent Office on 23 October 2024, and the entire contents of Japanese Patent Application No. 2024-166651 and Japanese Patent Application No. 2024-186588 are incorporated herein by reference.

[0286] 1. Fragile substrate 1A. First surface 1B. Second surface 1b. Substrate reinforcement layer 2. Printed layer 21. Second printed layer 3. Sealant layer 4. Gas barrier layer 4a. Vapor deposition layer 4b. Overcoat layer 10. Lid material 10A. Front surface 10B. Back surface 20. Container body 20A. First surface 110. Contents storage recess 110A. Opening 110B. Bottom 120. Cut line 130. Solid contents 131. Printed line 141. Printed line 142. Printed line a. Field of view b. Field of view c. Field of view L151. Line width L152. Line width L153. Line width L154. Line width L155. Line width 160. Micro-characters 100. Press-through pack packaging (PTP packaging)

Claims

1. A press-through pack packaging comprising: a container body including a plastic sheet having a plurality of content-containing recesses; solid contents contained in each of the plurality of content-containing recesses; and a lid material that closes the openings of the plurality of content-containing recesses, wherein the lid material comprises a fragile substrate including a resin film, a printed layer disposed on the fragile substrate, and a sealant layer, wherein the printed layer is formed by a printing method other than intaglio printing, or the fragile substrate has a vapor-deposited layer.

2. The press-through pack packaging according to claim 1, wherein the fragile substrate has a maximum unevenness height of 0.5 μm to 9.0 μm.

3. The press-through pack packaging according to claim 1 or claim 2, wherein the fragile base material has an MD tensile strength of 20 MPa to 50 MPa and a TD tensile strength of 20 MPa to 50 MPa.

4. The press-through pack packaging according to claim 1 or claim 2, wherein the fragile base material has a tensile elongation of 50% or less in both MD and TD.

5. The press-through pack packaging according to claim 1 or claim 2, wherein the puncture strength of the fragile base material is 8.0 N or less.

6. The press-through pack packaging according to claim 1 or claim 2, wherein the fragile base material includes polypropylene.

7. The press-through pack packaging according to claim 1 or claim 2, wherein the printed layer is formed by flexographic printing.

8. The press-through pack packaging according to claim 7, wherein the printing layer contains water-based ink.

9. The press-through pack packaging according to claim 7, wherein the printed layer contains security printing that includes one or more types selected from microcharacters and microfigures.

10. The press-through pack packaging according to claim 7, wherein the printed layer includes a rectangular figure, the area occupancy rate by the ink in the area where the ink of the rectangular figure is applied is 71% or more, and the standard deviation of the line width of the rectangular figure is 10 or less.

11. The press-through pack packaging according to claim 1 or claim 2, comprising a vapor-deposited layer on the fragile substrate.

12. The press-through pack packaging according to claim 11, further comprising a base material reinforcing layer on the fragile base material.

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