Gel-like oral composition

Abstract

Provided is a composition wherein an unpleasant odor, resulting from causing a gel-like oral composition containing vitamin B1 or a derivative thereof and vitamin C to simultaneously contain higher concentrations of vitamin B1 or a derivative thereof and vitamin C than conventional compositions, is reduced by means of a gel-like oral composition containing 0.00033 w / w% or more of vitamin B1 or a derivative thereof, 0.21 w / w% or more of vitamin C, and at least one mineral selected from sodium and calcium.

Description

Gel-like oral composition

[0001] This invention relates to a gel-like oral composition containing vitamin B1 or its derivatives and vitamin C. More specifically, it relates to a gel-like composition in which the unpleasant odor that occurs when vitamin B1 or its derivatives and vitamin C are contained simultaneously is reduced, and which can be applied in the fields of pharmaceuticals, quasi-drugs, and food products.

[0002] Vitamin B1 or its derivatives, and vitamin C or its derivatives are known for various medicinal effects, such as maintaining the health of the skin and mucous membranes and relieving fatigue, and are widely used in pharmaceuticals, quasi-drugs, and foods. In recent years, fatigue among modern people has become more diverse due to changes in lifestyle and climate change. However, it is known that combining vitamin B1 or its derivatives with vitamin C or its derivatives simultaneously can produce a distinctive unpleasant odor. To solve this problem, methods have been proposed to suppress the distinctive off-odor without impairing the medicinal effects of vitamin B1 by combining vitamin B1 or its derivatives with ascorbic acid in a specific ratio (Patent Document 1), and to suppress the bitterness derived from vitamin B1 by specifying vitamin C, pH, and Brix values ​​(Patent Document 2). However, methods for suppressing unpleasant odors are still not sufficient and various investigations are underway.

[0003] Furthermore, there is increasing demand for gel-type oral compositions such as cup jellies and jelly drinks, and there is a need for products that allow for easy intake of many nutrients and products that can easily satisfy hunger. Jelly drinks are lightweight, the containers do not break, making them highly portable, and they are also easy to drink for people of all ages, from children to the elderly, so they are in demand in diverse lifestyles. Vitamins B1 and C are not only included in beverages, but also in granules, tablets, gummies, and jellies, and since they are effective against fatigue, including them in jelly allows for easy hunger relief and fatigue care. In developing products in this form, suppressing unpleasant odors is essential, and there is a need for a simple method to suppress unpleasant odors. However, gel-type oral compositions tend to leave more unpleasant odors in the mouth than beverages, making it difficult to suppress unpleasant odors.

[0004] Japanese Patent No. 3901374, Japanese Unexamined Patent Application Publication No. 2018-148820

[0005] The inventors newly discovered that as the concentrations of vitamin B1 or its derivative and vitamin C in the gelled oral composition increase, the unpleasant odor increases. Therefore, an object of the present invention is to provide a composition in which the unpleasant odor derived from simultaneously containing vitamin B1 or its derivative (hereinafter sometimes also referred to as "vitamin B1 group") and vitamin C in a gelled oral composition containing a higher concentration of vitamin B1 or its derivative and vitamin C than before is reduced.

[0006] As a result of intensive studies to solve the above problems, the inventors found that by containing minerals in a gelled oral composition containing vitamin B1 group and vitamin C at specific concentrations, the unpleasant odor derived from simultaneously containing vitamin B1 group and vitamin C can be reduced. That is, the present invention provides: (1) a gelled oral composition containing 0.00033 w / w% or more of vitamin B1 or its derivative, 0.21 w / w% or more of vitamin C, and at least one mineral selected from sodium, calcium, iron, zinc, and magnesium; (2) the gelled oral composition according to (1), wherein the sodium content is 0.001 w / w% or more; (3) a method for suppressing an unpleasant odor by adding at least one mineral selected from sodium, calcium, iron, zinc, and magnesium to a gelled oral composition containing vitamin B1 or its derivative and vitamin C; (4) a gelled oral composition containing 0.00033 w / w% or more of vitamin B1 or its derivative, 0.21 w / w% or more of vitamin C, and at least one mineral selected from sodium and calcium; (5) the gelled oral composition according to (4), wherein the sodium content is 0.001 w / w% or more; (6) a method for suppressing an unpleasant odor by adding at least one mineral selected from sodium and calcium to a gelled oral composition containing vitamin B1 or its derivative and vitamin C.

[0007] The present invention makes it possible to provide a gel-like oral composition containing high concentrations of vitamin B1 and vitamin C, in which the unpleasant odor resulting from the simultaneous inclusion of vitamin B1 and vitamin C is reduced.

[0008] In the present invention, vitamin B1 or its derivatives (vitamin B1 group) refers to those that are normally edible, and examples include thiamine, dicethiamine, fursultiamine, thiamine disulfide, bis-butiamine, benfotiamine, sicotiamine, octotiamine, and prosultiamine. The origin of vitamin B1 or its derivatives is not relevant; it is sufficient that it is present in the composition as vitamin B1 or its derivatives. For example, salts of vitamin B1 or its derivatives can be used, and these may be nitrates, hydrochlorides, or sulfates.

[0009] Vitamin B1 or its derivatives are preferably thiamine, dicethiamine, fursultiamine, thiamine disulfide, bis-ibthiamine, benfotiamine, more preferably thiamine, fursultiamine, benfotiamine, and most preferably thiamine. When a salt of vitamin B1 or its derivative is used, it is preferably a nitrate, hydrochloride, or sulfate of vitamin B1 or its derivative, more preferably a nitrate, hydrochloride, or sulfate of thiamine, dicethiamine, fursultiamine, thiamine disulfide, bis-ibthiamine, benfotiamine, sicotiamine, octotiamine, or prosultiamine, even more preferably a nitrate, hydrochloride, or sulfate of thiamine, dicethiamine, fursultiamine, thiamine disulfide, bis-ibthiamine, or benfotiamine, and most preferably a nitrate, hydrochloride, or sulfate of thiamine, fursultiamine, or benfotiamine.

[0010] The vitamin B1 content in the present invention is 0.00033 w / w% or more of the total composition, preferably 0.00033 to 0.05 w / w%, more preferably 0.0004 to 0.04 w / w%, even more preferably 0.0006 to 0.03 w / w%, and even more preferably 0.0008 to 0.02 w / w%.

[0011] In the present invention, the origin of vitamin C is not important; it is sufficient that it is present as vitamin C in the composition. For example, inorganic salts and organic salts of vitamin C can be used, and may be sodium salts, calcium salts, or arginine salts, with sodium salts being preferred. The vitamin C content in the present invention is 0.21 w / w% or more of the total composition, preferably 0.21 to 5.0 w / w%, more preferably 0.25 to 4.0 w / w%, even more preferably 0.3 to 3.0 w / w%, and even more preferably 0.33 to 2.0 w / w%.

[0012] In the present invention, the vitamin C content is preferably 4 to 17,000 parts by mass, more preferably 5 to 14,000 parts by mass, even more preferably 15 to 3,750 parts by mass, and most preferably 16 to 2,500 parts by mass, per 1 part by mass of vitamin B1. In the gel-like oral composition of the present invention, as the content of vitamin B1 and vitamin C, or the vitamin C content relative to vitamin B1, increases, the problem of unpleasant odor resulting from the simultaneous inclusion of these substances becomes greater. Therefore, the higher the content of vitamin B1 and vitamin C, or the vitamin C content relative to vitamin B1, in the gel-like oral composition, the greater the significance of implementing the present invention. In the present invention, examples of minerals include sodium, calcium, iron, zinc, and magnesium, and preferably sodium and calcium. At least one of these minerals can be used.

[0013] The mineral content in the present invention is not particularly limited, but for example, the sodium content is 0.001 w / w% or more, preferably 0.001 to 0.5 w / w%, more preferably 0.01 to 0.4 w / w%, even more preferably 0.02 to 0.4 w / w%, even more preferably 0.03 to 0.4 w / w%, particularly preferably 0.04 to 0.3 w / w%, and most preferably 0.04 to 0.2 w / w% of the total composition. The sodium content in the present invention is preferably 0.02 to 1700 parts by mass, more preferably 0.2 to 1400 parts by mass, even more preferably 0.4 to 1400 parts by mass, even more preferably 1.5 to 500 parts by mass, particularly preferably 10 to 375 parts by mass, and most preferably 45 to 250 parts by mass per 1 part by mass of vitamin B1. The calcium content in the present invention is preferably 0.003 to 10 w / w%, more preferably 0.006 to 1 w / w%, even more preferably 0.02 to 1 w / w%, even more preferably 0.03 to 1 w / w%, particularly preferably 0.05 to 1 w / w%, and most preferably 0.06 to 0.5 w / w% of the total composition. The calcium content in the present invention is preferably 0.06 to 35,000 parts by mass, more preferably 0.1 to 3,500 parts by mass, even more preferably 0.4 to 2,000 parts by mass, even more preferably 0.6 to 1,250 parts by mass, particularly preferably 1.0 to 1,000 parts by mass, even more preferably 10 to 700 parts by mass, and most preferably 40 to 200 parts by mass per 1 part by mass of vitamin B1. The iron content in the present invention is preferably 0.001 to 0.2 w / w% of the total composition. In the present invention, the zinc content is preferably 0.00005 to 10 w / w% of the total composition. In the present invention, the magnesium content is preferably 0.00005 to 10 w / w% of the total composition.

[0014] In the present invention, the gel-like oral composition is typically one in which, after being placed on a 200-mesh sieve (200 openings per inch), the weight of the liquid that falls below the sieve after 1 minute is 20% or less of the total volume, preferably 18% or less, and more preferably 15% or less. A 200-mesh sieve can be purchased commercially; for example, a stainless steel test sieve from Nonaka Rikaki Seisakusho Co., Ltd. or a standard sieve from Iida Seisakusho Co., Ltd. may be used.

[0015] The thickening polysaccharides that can be used in the present invention are high-molecular-weight polysaccharides obtained from plants, seaweed, or fermentation processes, which exhibit viscosity or gelation when dissolved in water. The type of thickening polysaccharide in the present invention is not particularly limited, and examples include gellan gum, agar, carrageenan, xanthan gum, locust bean gum, tara gum, guar gum, tamarind seed gum, alginic acids (alginic acid, alginate), gelatin, pectin, glucomannan, fercereran, psyllium seed gum, curdlan, welan gum, karaya gum, hydroxymethylcellulose, konjac powder, etc., and one or more types can be selected and used as appropriate. Of these, gellan gum, agar, carrageenan, xanthan gum, locust bean gum, tara gum, guar gum, gelatin, pectin, glucomannan, and konjac powder are preferred from the viewpoint of suitability for manufacturing and versatility, more preferably gellan gum, agar, carrageenan, xanthan gum, locust bean gum, tara gum, guar gum, glucomannan, and konjac powder, even more preferably gellan gum, carrageenan, xanthan gum, and konjac powder, and even more preferably carrageenan, xanthan gum, and konjac powder.

[0016] Furthermore, the concentration of the thickening polysaccharide is not limited in any way, but may be, for example, 0.01 to 2.0 w / w%, preferably 0.05 to 1.5 w / w%, and more preferably 0.1 to 1.3 w / w%.

[0017] The pH of the gel-like oral composition of the present invention is preferably 3.0 to 5.0, more preferably 3.3 to 4.0, and particularly preferably 3.5 to 3.9, as this provides a good balance of sweetness and acidity and a pleasant texture.

[0018] The gel-like oral composition of the present invention may contain other vitamins, amino acids, peptides, proteins, sugars, dietary fiber, plant extracts, animal extracts, fruit juices, etc., as appropriate, within limits that do not impair the effects of the present invention.

[0019] The gel-like oral composition of the present invention may further contain, as needed, additives such as acidulants, antioxidants, stabilizers, colorants, flavorings, flavor modifiers, sweeteners (such as trehalose), preservatives, seasonings, bittering agents, fortifiers, and emulsifiers, to the extent that they do not impair the effects of the present invention.

[0020] The form of the gel-like oral composition in the present invention is not particularly limited, but it can be used in various forms of jelly, such as cup jelly, instant jelly, jelly drink, and frozen jelly. It may also be filled into an aluminum pouch with a spout. The gel-like oral composition of the present invention can be used in pharmaceuticals, quasi-drugs, and food and beverages.

[0021] The gel-like oral composition of the present invention can be manufactured by conventional methods. For example, the gel-like oral composition of the present invention can be manufactured by weighing each component, dissolving and stirring in an appropriate amount of purified water, adjusting the pH as necessary, adding the remaining purified water, filtering or heat sterilizing as appropriate, and filling into containers.

[0022] The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited in any way to these examples. (Examples 1-11) Gel-like oral compositions were prepared according to the formulations described in Tables 1-3 and the following method. After adding and dispersing pre-mixed powdered thickening polysaccharides and granulated sugar to water, vitamin C, thiamine nitrate, and sodium chloride, sodium hydroxide, or calcium lactate were added and dissolved, then the pH was adjusted with dipotassium hydrogen phosphate and phosphoric acid, and water was added to make the total volume. After that, the mixture was filled into an aluminum pouch with a spout, heated to 85°C for 20 minutes to sterilize, and then cooled with water for 10 minutes. (Comparative Examples 1-6) Gel-like oral compositions were prepared according to the formulations described in Tables 1-3 and the following method. After adding and dispersing pre-mixed powdered thickening polysaccharides and granulated sugar to water, vitamin C and thiamine nitrate were added and dissolved, then the pH was adjusted with dipotassium hydrogen phosphate, and water was added to make the total volume. The contents were then filled into aluminum pouches with spouts, heated to 85°C for 20 minutes to sterilize, and then cooled with water for 10 minutes.

[0023] (Evaluation) After storing the gel-like oral composition at 65°C for 6 hours, samples were stored at 5°C for at least one day. Approximately 20g of the sample was then placed in a plastic cup (Tokan Kogyo Co., Ltd., CP61-100ST). Three trained expert panelists smelled the samples and evaluated the intensity of the unpleasant odor (also referred to as "unpleasant odor") resulting from the simultaneous inclusion of vitamins B1 and vitamin C, using the seven-level evaluation criteria shown in Table 4. The results were comprehensively evaluated by the three expert panelists.

[0024] Furthermore, a 50g sample of the manufactured gel-like oral composition, stored at 5°C for at least one day, was placed on a 200-mesh sieve (a stainless steel test sieve from Nonaka Rikaki Seisakusho Co., Ltd.). The weight of the liquid that fell through the sieve after one minute was recorded as a percentage of the total volume.

[0025]

[0026]

[0027]

[0028]

[0029] The results of the studies shown in Tables 1-3 showed that the unpleasant odor was reduced in the examples compared to the comparative examples. Similar to sodium and calcium, iron, zinc, and magnesium can also be expected to have an effect in reducing unpleasant odors. Table 5 shows examples of formulations.

[0030]

[0031] This invention makes it possible to provide a gel-like oral composition in which the unpleasant odor resulting from the simultaneous inclusion of vitamin B1 and vitamin C is reduced. Therefore, by providing this invention as a pharmaceutical, quasi-drug, or food product that allows for the intake of vitamins and other nutrients, the development of these industries is expected.

Claims

1. A gel-like oral composition containing 0.00033 w / w% or more of vitamin B1 or its derivative, 0.21 w / w% or more of vitamin C, and at least one mineral selected from sodium and calcium.

2. The gel-like oral composition according to claim 1, wherein the sodium content is 0.001 w / w% or more.

3. A method for suppressing unpleasant odors by adding at least one mineral selected from sodium and calcium to a gel-like oral composition containing vitamin B1 or a derivative thereof and vitamin C.

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