Lipid nanoparticles for bioproduction
Lipid nanoparticles encapsulating plasmid DNA with inducible promoters address the high cost of growth factors in bioproduction by enabling efficient and controlled expression in target cells, enhancing scalability and sustainability.
WO2026090607A1 Publication Date: 2026-04-30WORCESTER POLYTECHNIC INSTITUTE
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Patent Information
- Application Number
- PCT/US2025/052669
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-10-25
- Filing Date
- 2025-10-27
- Publication Date
- 2026-04-30
AI Technical Summary
Technical Problem
Conventional bioproduction methods face high costs due to the need for expensive growth factors and biomolecules, limiting scalability and sustainability in biomanufacturing for food and pharmaceuticals, while existing nonviral gene therapies are costly and inefficient for cell engineering.
Method used
Lipid nanoparticles (LNPs) encapsulate plasmid DNA encoding growth factors with inducible promoters to induce transient expression in target cells, reducing the need for external growth factors and lowering production costs.
Benefits of technology
The LNP-based delivery system enables efficient and controlled expression of growth factors, maintaining cell proliferation and reducing logistical challenges, thus enhancing scalability and economic viability of biomanufacturing.
✦ Generated by Eureka AI based on patent content.
Abstract
A nonviral gene therapy delivers DNA that allows cells to produce proteins such as their own growth factors in culture media. Lipid nanoparticles provide an effective delivery mechanism into a target cell. By encapsulating plasmid DNA encoding the growth factors with inducible promoters into lipid nanoparticles (LNPs), target cells create their own growth factors reducing a need for expensive growth factors from external sources. DNA expression lasts for several days reducing the amount of reagent needed. The plasmid DNA is more stable than mRNA and proteins, therefore reducing logistical challenges.
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