Specimen separator and specimen separation method

Abstract

Disclosed are a specimen separator and a specimen separation method. The specimen separator of the present invention comprises: a blade which extends in the longitudinal direction from a first blade side edge and is connected to a second blade side edge; and a base fixer including a base fixer body which extends in the longitudinal direction and is coupled to the blade, wherein a blade base edge forming the lower end of the blade extends in the longitudinal direction from the lower end of the first blade side edge, is connected to the lower end of the second blade side edge, and is coupled to the base fixer body, and the upper surface of the base fixer body may be connected to the blade.

Description

Sample separator and sample separation method

[0001] The present invention relates to a sample separator and a sample separation method.

[0002] Generally, tissue slides are prepared for the observation of tissue specimens in hospital pathology departments, clinical pathology laboratories, and the like. Tissue slides can be prepared by thinly cutting (i.e., sectioning) a specimen block containing a tissue specimen (hereinafter abbreviated as specimen) to create specimen sections, placing the sections on a slide, and melting a wax-like medium.

[0003] For example, a specimen block can be prepared by embedding the specimen in a waxy medium such as paraffin or celloidin. For example, a specimen block can be prepared by injecting a waxy medium into the interior of a cassette (or mold) containing the specimen and curing it.

[0004] Meanwhile, when multiple specimens are embedded in a specimen block, situations requiring re-embedding may occur (e.g., when it is necessary to change the order of multiple specimens or separate them individually).

[0005] In this case, a sample block containing multiple samples is placed in a mold and the waxy medium is melted, but the samples become mixed as the waxy medium melts. Consequently, the distinction between the samples may become ambiguous.

[0006] Therefore, when dissolving a specimen block containing multiple embedded specimens for re-embedding, a method is required to distinguish the specimens from one another once the waxy medium has completely dissolved.

[0007] One objective of the present invention is to provide a sample separator and a sample separation method for compartmentalizing and separating a plurality of samples contained in a sample block.

[0008] According to one aspect of the present invention, a sample separator may be provided comprising: a blade extending longitudinally from a first blade side edge and continuing to a second blade side edge; and a base fixer body extending longitudinally and coupled to the blade, wherein a blade base edge forming the lower end of the blade extends longitudinally from the lower end of the first blade side edge and continues to the lower end of the second blade side edge and is coupled to the base fixer body, and the upper surface of the base fixer body is connected to the blade.

[0009] The thickness of the blade may decrease as it goes upward from the blade base edge.

[0010] The base fixer may further include a fixer wing extending from the base fixer body in the thickness direction of the blade.

[0011] The base fixer may further include a first fixer wing extending from the base fixer body in the thickness direction of the blade and adjacent to the first blade side edge; and a second fixer wing extending from the base fixer body in the thickness direction of the blade and adjacent to the second blade side edge.

[0012] The sample separator may further include at least one blade module comprising the blade and the base fixer, respectively; and a frame module coupled to the base fixer.

[0013] The above frame module comprises: a first frame bar and a second frame bar that each extend in one direction and face each other; a plurality of first frame couplers formed on the first frame bar; and

[0014] The base fixer may include a plurality of second frame couplers formed on the second frame bar, and the base fixer may include a first base fixer coupler coupled to one of the plurality of first frame couplers; and a second base fixer coupler coupled to one of the plurality of second frame couplers.

[0015] The first base fixer coupler protrudes downward from the lower surface of the base fixer body and is adjacent to the first blade side edge, and the second base fixer coupler protrudes downward from the lower surface of the base fixer body and is adjacent to the second blade side edge.

[0016] The above frame module comprises: a first frame bar and a second frame bar, each extending in one direction and having inner surfaces facing each other; a plurality of first frame couplers formed concavely on the inner surface of the first frame bar; and a plurality of second frame couplers formed concavely on the inner surface of the second frame bar, wherein one end of the base fixer body may be coupled to one of the plurality of first frame couplers, and the other end of the base fixer body may be coupled to one of the plurality of second frame couplers.

[0017] According to one aspect of the present invention, the invention comprises at least one blade module and a frame module coupled to the at least one blade module, wherein the frame module comprises: a first frame bar and a second frame bar each extending in one direction and facing each other; a plurality of first side frame couplers formed on the first frame bar; and a plurality of second side frame couplers formed on the second frame bar, wherein each of the at least one blade module comprises: a blade extending longitudinally from a first blade side edge and continuing to a second blade side edge; a first side fixer coupler fixed to the first blade side edge and coupled to one of the plurality of first side frame couplers; and

[0018] A sample separator may be provided, comprising a second side fixer coupler coupled to the second blade side edge and coupled to one of the plurality of second side frame couplers.

[0019] Each of the plurality of first side frame couplers may form a recessed shape on the upper surface and inner surface of the first frame bar, and each of the plurality of second side frame couplers may form a recessed shape on the upper surface and inner surface of the second frame bar.

[0020] According to one aspect of the present invention, a sample separation method (S10) may be provided, comprising the steps of: partitioning a sample block formed by a wax-like medium that encloses a plurality of samples with at least one blade module (S100); placing the sample block in a mold (S200); and heating the mold (S300).

[0021] The above partitioning step (S100) may include: a step of setting a partition line on the upper surface of the sample block (S110); a step of combining at least one blade module with a frame module (S120); and a step of lowering the at least one blade module from above the partition line and inserting it into the sample block (S130).

[0022] According to at least one of the embodiments of the present invention, a sample separator and a sample separation method for compartmentalizing and separating a plurality of samples contained in a sample block may be provided.

[0023] FIG. 1 is a drawing showing a blade according to one embodiment of the present invention.

[0024] FIG. 2 is a drawing showing a blade module according to one embodiment of the present invention.

[0025] Figure 3 is a schematic diagram showing the blade module illustrated in Figure 2 partitioning a sample block.

[0026] Figure 4 is a drawing showing a frame module including a base frame coupler.

[0027] Figure 5 is a drawing showing a base fixer coupler added to the blade module shown in Figure 2.

[0028] Figure 6 is a drawing showing a frame module including a side frame coupler.

[0029] Figure 7 is a drawing showing a side fixer coupler added to the blade illustrated in Figure 1.

[0030] Figure 8 is a drawing showing a fixer wing formed on the blade module illustrated in Figure 2.

[0031] Figure 9 is a schematic diagram showing a blade inserted into a sample block.

[0032] FIG. 10 is a flowchart illustrating a sample separation method according to one embodiment of the present invention.

[0033] Hereinafter, embodiments disclosed in this specification will be described in detail with reference to the attached drawings. Identical or similar components regardless of drawing symbols are assigned the same reference number, and redundant descriptions thereof will be omitted. The suffixes "module" and "part" used for components in the following description are assigned or used interchangeably solely for the ease of drafting the specification and do not inherently possess distinct meanings or roles. Furthermore, in describing the embodiments disclosed in this specification, if it is determined that a detailed description of related prior art could obscure the essence of the embodiments disclosed in this specification, such detailed description will be omitted. Additionally, the attached drawings are intended only to facilitate understanding of the embodiments disclosed in this specification; the technical concept disclosed in this specification is not limited by the attached drawings, and it should be understood that they include all modifications, equivalents, and substitutions that fall within the spirit and technical scope of the invention.

[0034] Terms including ordinal numbers, such as first, second, etc., may be used to describe various components, but said components are not limited by said terms. These terms are used solely for the purpose of distinguishing one component from another.

[0035] When it is stated that one component is "connected" or "connected" to another component, it should be understood that while it may be directly connected or connected to that other component, there may also be other components in between. On the other hand, when it is stated that one component is "directly connected" or "directly connected" to another component, it should be understood that there are no other components in between.

[0036] A singular expression includes a plural expression unless the context clearly indicates otherwise.

[0037] In this application, terms such as “comprising” or “having” are intended to specify the existence of the features, numbers, steps, actions, components, parts, or combinations thereof described in the specification, and should be understood as not precluding the existence or addition of one or more other features, numbers, steps, actions, components, parts, or combinations thereof.

[0038] In the drawings, the size of components may be exaggerated or reduced for convenience of explanation. For example, the size and thickness of each component shown in the drawings are depicted arbitrarily for convenience of explanation, so the present invention is not necessarily limited to what is illustrated.

[0039] Where an embodiment can be implemented differently, a specific process sequence may be performed differently from the order described. For example, two processes described consecutively may be performed substantially simultaneously or proceed in the reverse order of the description.

[0040] In the following embodiments, when a membrane, region, component, etc. is described as being connected, it includes not only cases where the membrane, region, or component is directly connected, but also cases where other membranes, regions, or components are interposed between them to form an indirect connection. For example, when a membrane, region, component, etc. is described as being electrically connected in this specification, it includes not only cases where the membrane, region, or component, etc. are directly electrically connected, but also cases where other membranes, regions, or components are interposed between them to form an indirect electrical connection.

[0041] FIG. 1 is a drawing showing a blade according to one embodiment of the present invention.

[0042] Referring to FIG. 1, the blade (110) may include a blade body (111). The blade body (111) may form a shape that extends in one direction. For example, the blade body (111) may extend from a first blade side edge (112s1) to a second blade side edge (112s2).

[0043] The longitudinal direction of the blade (110) may be the longitudinal direction of the blade body (111). The longitudinal direction of the blade body (111) may be parallel to the direction from the first blade side edge (112s1) toward the second blade side edge (112s2).

[0044] The blade side edge (112s) may include or mean at least one of the first blade side edge (112s1) and the second blade side edge (112s2). The blade side edge (112s) may be part of the perimeter of the blade body (111).

[0045] The blade top edge (112t) can be extended longitudinally from one end of the first blade side edge (112s1) and connected to one end of the second blade side edge (112s1).

[0046] For example, the blade top edge (112t) may extend longitudinally from the top of the first blade side edge (112s1) and connect to the top of the second blade side edge (112s1). For example, the blade top edge (112t) may form the upper edge of the blade (110).

[0047] The blade base edge (112b) can be extended longitudinally from the other end of the first blade side edge (112s1) and connected to the other end of the second blade side edge (112s1).

[0048] For example, the blade base edge (112b) may extend longitudinally from the bottom of the first blade side edge (112s1) and connect to the bottom of the second blade side edge (112s1). For example, the blade base edge (112b) may form the lower edge of the blade (110).

[0049] The blade base edge (112b) and the blade top edge (112t) may be located opposite each other. The first blade side edge (112s1) and the second blade side edge (112s2) may be located opposite each other.

[0050] The blade base edge (112b), blade side edge (112s), and blade top edge (112t) may form the circumference of the blade (110). For example, the blade edge (112) may include or refer to at least one of the blade base edge (112b), blade side edge (112s), and blade top edge (112t).

[0051] The blade (110) may include a blade fixing portion (113). The blade fixing portion (113) may be formed or coupled to one end of the blade body (111). For example, the blade fixing portion (113) may be integrally formed at the lower end of the blade body (111). The blade fixing portion (113) may form a blade base edge (112b).

[0052] The blade (110) can form the shape of a plate. For example, the thickness of the blade (110) may decrease from the blade base edge (112b) to the blade top edge (112t).

[0053] The blade (110) can maintain rigidity. For example, the blade (110) can be formed from a material including metal. For example, the blade (110) can be formed from a material including polymer, plastic, etc. The blade (110) can be flexible.

[0054] FIG. 2 is a drawing showing a blade module according to one embodiment of the present invention.

[0055] Referring to FIGS. 1 and 2, the blade module (100) may include a blade (110). The blade module (100) may include a fixer (120). The fixer (120) may be coupled to the blade (110).

[0056] For example, the blade module (100) may include a base fixer (120b). The fixer (120) may include or mean at least one of the base fixer (120b) and the side fixer (120s, see FIG. 7).

[0057] The base fixer (120b) can be coupled to the blade (110). For example, the base fixer (120b) can be coupled to the blade fixing part (113). For example, the base fixer (120b) can be formed from a material including a polymer, plastic, etc. For example, the base fixer (120b) can be formed by injection molding with the blade (110).

[0058] The blade (110) can form a shape that extends from the base fixer (120b) and continues to the blade top edge (112t). The longitudinal direction of the base fixer (120b) can be parallel to the longitudinal direction of the blade (110).

[0059] For example, the blade (110) can form a shape that extends upward from the upper face of the base fixer (120b). For example, the lower face of the base fixer (120b) can be flat. The distance between the upper face and the lower face of the base fixer (120b) can form the thickness of the base fixer (120b).

[0060] The longitudinal length of the base fixer (120b) may be 1 cm to 5 cm, 1.5 cm to 4 cm, 2 cm to 3.5 cm, or 2.4 cm to 2.6 cm. For example, the longitudinal length of the base fixer (120b) may be approximately 2.5 cm. The width of the base fixer (120b) may be 1 mm to 5 mm or 2 mm to 4 mm. For example, the width of the base fixer (120b) may be approximately 3 mm. The width direction of the base fixer (120b) may be the thickness direction of the blade (110).

[0061] For example, the base fixer (120b) may extend longitudinally from the first stage and lead to the second stage. For example, the first stage of the base fixer (120b) may be adjacent to or meet the first blade side edge (112s1). For example, the second stage of the base fixer (120b) may be adjacent to or meet the second blade side edge (112s2).

[0062] An engraving, mark, etc., may be formed on at least one of the lower surface and the upper surface of the base fixer (120b). The blade module (100) can be identified through the mark or engraving displayed on at least one of the lower surface and the upper surface of the base fixer (120b). For example, an engraving, mark, etc., may be formed on the upper surface of the base fixer (120b), and in this case, when the sample block melts while the lower surface of the base fixer (120b) supports the blade module (100), the sample can be identified by the engraving, mark, etc. displayed on the base fixer (120b).

[0063] The width of the blade (110) may refer to the distance or height of the blade top edge (122b) relative to the base fixer (120b). The width of the blade (110) may be, for example, 1 mm to 10 mm, 1 mm to 7.5 mm, 1 mm to 5 mm, or 2 mm to 4 mm. For example, the width of the blade (110) may be about 3 mm.

[0064] The length of the blade (110) may refer to the longitudinal length of the blade (110). The length of the blade (110) may be substantially the same as the longitudinal length of the base fixer (120b). For example, the length of the blade (110) may be 10 mm to 50 mm, 15 mm to 40 mm, 20 mm to 35 mm, or 24 mm to 26 mm. For example, the length of the blade (110) may be about 25 mm.

[0065] For example, the thermal conductivity of the blade (110) may be 20 W / m·K or higher, 30 W / m·K or higher, 50 W / m·K or higher, or 100 W / m·K or higher. For example, the thermal conductivity of the blade (110) may be 1000 W / m·K or lower or 500 W / m·K or lower. For example, the thermal conductivity of the fixer (120) may be 20 W / m·K or higher, 30 W / m·K or higher, 50 W / m·K or higher, or 100 W / m·K or higher. For example, the thermal conductivity of the fixer (120) may be 1000 W / m·K or lower or 500 W / m·K or lower. In this case, when melting the sample block (1000), that is, when melting a waxy medium such as paraffin or celloidin, heat can be transferred more effectively to the sample block (1000).

[0066] Figure 3 is a schematic diagram showing the blade module illustrated in Figure 2 partitioning a sample block.

[0067] Referring to FIGS. 1 to 3, the specimen block (1000) may include a wax-like medium such as paraffin or celloidin. The specimen block (1000) may include a tissue specimen (T1, T2) wrapped in a wax-like medium such as paraffin or celloidin. Hereinafter, for convenience of explanation, the tissue specimen may be abbreviated as "specimen." Also, for convenience of explanation, the wax-like medium is assumed to be paraffin.

[0068] The sample block (1000) may be solid at 0°C to 40°C. For example, the sample block (1000) may be solid at room temperature (about 25°C). For example, the paraffin contained in the sample block (1000) may be solid at 0°C to 40°C. For example, the paraffin contained in the sample block (1000) may be solid at room temperature (about 25°C).

[0069] The specimens (T1, T2) may be multiple. For example, the specimen block (1000) may include a first specimen (T1) and a second specimen (T2) wrapped in paraffin. The multiple specimens (T1, T2) may be spaced apart from each other.

[0070] The blade module (100) can partition the sample block (1000). For example, the blade module (100) can be inserted into the interior of the sample block (1000) to partition the sample block (1000). For example, the sample block (1000) can be partitioned into two by the blade module (100). For example, the blade (110) can be positioned between the first sample (T1) and the second sample (T2).

[0071] The base fixer (120b) may be located on the lower surface of the sample block (1000). The blade top edge (112t) may be located on or adjacent to the upper surface of the sample block (1000). For example, the blade top edge (112t) may be located above the upper surface of the sample block (1000). In other words, the blade (110) may form a shape that protrudes upward from the sample block (1000). As another example, the blade top edge (112t) may be located below the upper surface of the sample block (1000). In other words, the blade (110) may be inserted into the interior of the sample block (1000) but may not protrude through the sample block (1000). That is, the sample block (1000) may not be completely cut and separated into multiple pieces by the blade (110). Accordingly, the inconvenience of the sample block being separated into multiple parts before the paraffin is melted can be prevented, and the blade (110) can perform a partition function during the process of melting the paraffin.

[0072] The process of the blade module (100) partitioning the sample block (1000) can be observed. For example, with the blade top edge (112t) positioned above the base fixer (120b), the sample block (1000) can descend from above the blade module (100). Through this process, the sample block (1000) can be partitioned by the blade module (100).

[0073] In another example, the blade module (100) can be positioned on the sample block (1000) while the base fixer (120b) is positioned on the blade top edge (112t). When the blade module (100) is lowered, the sample block (1000) can be partitioned by the blade module (100). Afterward, the sample block (1000) and the blade module (100) can be flipped over.

[0074] The mold (20) may include a mold body (21). The mold body (21) may form a hollow portion that is open upward. For example, the inner surface of the mold body (21) may be concave and face the hollow portion. For example, the outer surface of the mold body (21) may be convex.

[0075] The sample block (1000) and the blade module (100) can be accommodated in the mold (20). For example, the sample block (1000) and the blade module (100) can be accommodated in the mold body (21). When the sample block (1000) and the blade module (100) are accommodated in the mold body (21), the base fixer (120b) can be located on the inner bottom surface of the mold body (21).

[0076] The mold (20) may include a mold wing (22). The mold wing (22) may form a shape extending horizontally from the upper part of the mold body (21).

[0077] The mold (20) can be heated. When the mold (20) is heated, the sample block (1000) can receive heat from the mold (20). When the sample block (1000) is heated, the temperature of the sample block (1000) can be increased.

[0078] For example, the temperature of the sample block (1000) may be raised to 55°C to 90°C, 60°C to 85°C, or 65°C to 80°C. For example, the sample block (1000) may be raised to about 60°C or about 65°C. When the temperature of the sample block (1000) is raised, the paraffin contained in the sample block (1000) may be converted from a solid state to a liquid state.

[0079] Even if the paraffin contained in the sample block (1000) changes into a liquid state, the first sample (T1) and the second sample (T2) can remain separated by the blade module (100). When the paraffin contained in the sample block (1000) is in a liquid state, the first sample (T1) and the second sample (T2) can be collected separately.

[0080] Figure 4 is a drawing showing a frame module including a base frame coupler.

[0081] Referring to FIG. 4, the frame module (200) may include a frame bar (210). The frame bar (210) may be provided in multiple numbers. For example, the frame module (200) may include a first frame bar (211), a second frame bar (212), a third frame bar (213), and a fourth frame bar (214).

[0082] The frame bar (210) may include or mean at least one of the first frame bar (211), the second frame bar (212), the third frame bar (213), and the fourth frame bar (214). The first frame bar (211), the third frame bar (213), the second frame bar (212), and the fourth frame bar (214) may be connected sequentially.

[0083] A plurality of frame bars (210) can form a frame shape overall. The size of the frame bars (210) may correspond to the size of the mold body (21, see FIG. 3). The size of the frame bars (210) may correspond to the length of the blade module (100, see FIG. 2).

[0084] The frame module (200) may include a frame coupler (220). For example, the frame module (200) may include a base frame coupler (220b). The frame coupler (220) may include or mean at least one of a base frame coupler (220b) and a side frame coupler (220s, see FIG. 6).

[0085] For example, the base frame coupler (220b) may be a hole formed in the frame bar (210). For example, the base frame coupler (220b) may form a recessed shape on the upper surface of the frame bar (210). As another example, the base frame coupler (220b) may be a through hole formed in the frame bar (210). For example, the base frame coupler (220b) may form a shape that penetrates the upper and lower surfaces of the frame bar (210).

[0086] The base frame couplers (220b) may be provided in multiple numbers. For example, multiple base frame couplers (220b) may be arranged sequentially along the frame bar (210). Multiple base frame couplers (220b) may be arranged on two frame bars (211, 212) facing each other.

[0087] For example, a plurality of base frame couplers (220b) located on the first frame bar (211) may be arranged sequentially along the first frame bar (211). A plurality of base frame couplers (220b) located on the first frame bar (211) may be referred to as a plurality of "first base frame couplers".

[0088] For example, a plurality of base frame couplers (220b) located on the second frame bar (212) may be arranged sequentially along the second frame bar (212). A plurality of base frame couplers (220b) located on the second frame bar (212) may be referred to as a plurality of "second base frame couplers".

[0089] Figure 5 is a drawing showing a base fixer coupler added to the blade module shown in Figure 2.

[0090] Referring to FIG. 5, the fixer (120) may include a fixer coupler (122). For example, the base fixer (120b) may include a base fixer coupler (122b). The fixer coupler (122) may include or mean at least one of the base fixer coupler (122b) and the side fixer coupler (122s, see FIG. 7).

[0091] The base fixer coupler (122b) may be connected to or coupled with the base fixer body (121b). For example, the base fixer coupler (122b) may form a protruding shape that protrudes downward from the lower surface of the base fixer body (121b). The base fixer coupler (122b) may be formed integrally with the base fixer body (121b).

[0092] The base fixer coupler (122b) may be multiple. For example, the base fixer (120b) may include a first base fixer coupler (122b1) and a second base fixer coupler (122b2). The base fixer coupler (122b) may include or mean at least one of the first base fixer coupler (122b1) and the second base fixer coupler (122b2).

[0093] The first base fixer coupler (122b1) and the second base fixer coupler (122b2) may be spaced apart from each other. For example, the first base fixer coupler (122b1) may be adjacent to the first blade side edge (122s1). For example, the second base fixer coupler (122b2) may be adjacent to the second blade side edge (122s2).

[0094] Referring to FIGS. 4 and 5, the blade module (100) and the frame module (200) can be combined with each other. For example, the blade module (100) and the frame module (200) can be separated from each other.

[0095] For example, the fixer (120) can be coupled to the frame module (200). For example, the base fixer coupler (122b) can be coupled to the base frame coupler (220b). For example, the base fixer coupler (122b) can be detachably inserted into the base frame coupler (220b).

[0096] For example, the first base fixer coupler (122b1) may be coupled to one of a plurality of base frame couplers (220b) located on the first frame bar (211). For example, the second base fixer coupler (122b2) may be coupled to one of a plurality of base frame couplers (220b) located on the second frame bar (212).

[0097] Figure 6 is a drawing showing a frame module including a side frame coupler.

[0098] Referring to FIG. 6, the frame module (200) may include a side frame coupler (220s). The side frame coupler (220s) may form a recessed shape on the upper surface and inner surface of the frame bar (210).

[0099] For example, the side frame coupler (220s) may form a shape protruding from the inner surface of the frame bar (210). For example, between two adjacent side frame couplers (220s), a shape of a projection protruding from the inner surface of the frame bar (210) may be formed.

[0100] The side frame couplers (220s) may be provided in plurality. For example, the plurality of side frame couplers (220s) may form a groove on the inner surface of the frame bar (210). For example, the plurality of side frame couplers (220s) may form a groove pattern on the inner surface of the frame bar (210).

[0101] For example, a plurality of side frame couplers (220s) may be arranged sequentially along the frame bar (210). For example, a plurality of side frame couplers (220s) may be arranged on two frame bars (211, 212) facing each other.

[0102] For example, a plurality of side frame couplers (220s) located on the first frame bar (211) may be arranged sequentially along the first frame bar (211). The plurality of side frame couplers (220s) located on the first frame bar (211) may be referred to as a plurality of "first side frame couplers".

[0103] For example, a plurality of side frame couplers (220s) located on the second frame bar (212) may be arranged sequentially along the second frame bar (212). The plurality of side frame couplers (220s) located on the second frame bar (212) may be referred to as a plurality of "second side frame couplers".

[0104] The first frame coupler may include or mean at least one of a first base frame coupler (220b, see FIG. 4) and a first side frame coupler (220s). The second frame coupler may include or mean at least one of a second base frame coupler (220b, see FIG. 4) and a second side frame coupler (220s).

[0105] The side frame coupler (220s) can form a shape that extends in the insertion direction of the fixer coupler (122, see FIG. 5 and FIG. 7). For example, the side frame coupler (220s) can form a shape that extends in the vertical direction.

[0106] The frame module (200) may include a frame stopper (230). The frame stopper (230) may be formed on the frame bar (210). The frame stopper (230) may block the bottom of the side frame coupler (220s).

[0107] For example, the frame stopper (230) may be located below the side frame coupler (220s). For example, the frame stopper (230) may prevent the downward movement of the fixer coupler (122, see FIG. 5 and FIG. 7) as it descends along the side frame coupler (220s).

[0108] Figure 7 is a drawing showing a side fixer coupler added to the blade illustrated in Figure 1.

[0109] Referring to FIGS. 1 and FIGS. 7, the blade module (100) may include a side fixer coupler (122s). The side fixer coupler (122s) may be coupled to the blade (110). For example, the side fixer coupler (122s) may be coupled to the blade side edge (112s) of the blade (110).

[0110] The side fixer coupler (122s) may be provided in multiple numbers. For example, the side fixer coupler (122s) may include or mean at least one of a first side fixer coupler (122s1) and a second side fixer coupler (122s2).

[0111] The first side fixer coupler (122s1) and the second side fixer coupler (122s2) can be coupled to the blade (110). For example, the first side fixer coupler (122s1) can be coupled to the first blade side edge (112s1). For example, the second side fixer coupler (122s2) can be coupled to the second blade side edge (112s2).

[0112] The side fixer coupler (122s) can form a shape that extends along the blade side edge (112s). For example, the longitudinal direction of the side fixer coupler (122s) may be the width direction of the blade (110). For example, the longitudinal direction of the side fixer coupler (122s) may be the vertical direction.

[0113] For example, the blade (110) can be fixed to the side fixer coupler (122s). For example, the blade (110) can be fitted into and coupled to the side fixer coupler (122s). As another example, the side fixer coupler (122s) can be injection molded with the blade (110).

[0114] For example, the side fixer coupler (122s) may be formed from a material including a polymer. For example, the side fixer coupler (122s) may be formed from a material including plastic.

[0115] Referring to FIGS. 1, 6 and 7, the blade module (100) and the frame module (200) can be combined with each other. For example, the blade module (100) and the frame module (200) can be detachably combined with each other.

[0116] For example, the fixer (120) can be coupled to the frame module (200). For example, the side fixer coupler (122s) can be coupled to the side frame coupler (220s). For example, the side fixer coupler (122s) can be detachably coupled to the side frame coupler (220s). For example, the side fixer coupler (122s) can be detachably inserted or fitted into the side frame coupler (220s).

[0117] For example, the first side fixer coupler (122s1) may be coupled to one of a plurality of side frame couplers (220s) located on the first frame bar (211). For example, the second side fixer coupler (122s2) may be coupled to one of a plurality of side frame couplers (220s) located on the second frame bar (212).

[0118] For another example, referring to FIGS. 5 and 6, the base fixer coupler (122b) can be coupled to the side frame coupler (220s). For example, the base fixer coupler (122b) can be detachably inserted or fitted into the side frame coupler (220s).

[0119] For example, the first base fixer coupler (122b1) may be coupled to one of a plurality of side frame couplers (220s) located on the first frame bar (211). For example, the second base fixer coupler (122b2) may be coupled to one of a plurality of side frame couplers (220s) located on the second frame bar (212).

[0120] For another example, referring to FIGS. 2, 5 and 6, the base fixer body (121b) can be coupled to a side frame coupler (220s). For example, both ends of the base fixer body (121b) can be coupled to a side frame coupler (220s).

[0121] For example, the first end of the base fixer body (121b) may be adjacent to the first blade side edge (112s1), and the second end of the base fixer body (121b) may be adjacent to the second blade side edge (112s2).

[0122] For example, the first end of the base fixer body (121b) may be coupled to one of a plurality of side frame couplers (220s) located on the first frame bar (211). For example, the second end of the base fixer body (121b) may be coupled to one of a plurality of side frame couplers (220s) located on the second frame bar (212).

[0123] Figure 8 is a drawing showing a fixer wing formed on the blade module illustrated in Figure 2.

[0124] Referring to FIG. 8, the fixer (120) may include a fixer body (121). The fixer body (121) shown in FIG. 8 may be the same as the base fixer (120b) shown in FIG. 2. The longitudinal direction of the fixer body (121) may be the longitudinal direction of the blade (110).

[0125] The fixer (120) may include a fixer wing (123). The fixer wing (123) may extend from the fixer body (121). The direction in which the fixer wing (123) extends from the fixer body (121) may be the thickness direction of the blade (110).

[0126] The lower surface of the fixer wing (123) can be connected to the lower surface of the fixer body (121). The fixer wing (123) may be provided in multiple numbers. For example, one of a pair of fixer wings (123) may be adjacent to the first blade side edge (112s1), and the other of the pair of fixer wings (123) may be adjacent to the second blade side edge (112s2).

[0127] For example, among a pair of fixer wings (123), the fixer wing (123) adjacent to the first blade side edge (112s1) may be referred to as the "first fixer wing." For example, among a pair of fixer wings (123), the fixer wing (123) adjacent to the second blade side edge (112s2) may be referred to as the "second fixer wing."

[0128] Referring to FIGS. 3 and FIGS. 8, when the blade module (100) is received in the mold (20), the fixer wing (123) can increase the area where the blade module (100) faces the inner surface of the mold body (21). By doing so, the blade module (100) can be positioned more stably in the mold body (21).

[0129] Figure 9 is a schematic diagram showing a blade inserted into a sample block.

[0130] Referring to FIGS. 1 to 9, the sample block (1000) may include a plurality of samples (T1, T2, T3, T4). The plurality of samples (T1, T2, T3, T4) may be arranged sequentially.

[0131] For example, the first sample (T1), the second sample (T2), the third sample (T3), and the fourth sample (T4) may be arranged sequentially. Multiple samples (T1, T2, T3, T4) may be sequentially partitioned by at least one blade (110).

[0132] The blade module (100) may include or mean at least one of a first blade module (100a), a second blade module (100b), and a third blade module (100c).

[0133] For example, the first blade module (100a) can partition the first sample (T1) and the second sample (T2). For example, the second blade module (100b) can partition the second sample (T2) and the third sample (T3). For example, the third blade module (100c) can partition the third sample (T3) and the fourth sample (T4).

[0134] The blade module (100) can be bent. For example, the blade module (100) can be bent depending on the shape and arrangement of two adjacent specimens (T1, T2). For example, the first blade module (100a) can be bent.

[0135] The lengths of the multiple blade modules (100a, 100b, 100c) may differ from each other. For example, the lengths of the blades (110) of the multiple blade modules (100a, 100b, 100c) may differ from each other.

[0136] For example, the length of the blade (110) of the first blade module (100a) may be greater than the length of the blade (110) of the second blade module (100b). For example, the length of the blade (110) of the first blade module (100a) may be greater than the length of the blade (110) of the third blade module (100c). Thus, a blade (110) of the required length can be selected according to the shape and arrangement of a plurality of specimens (T1, T2, T3, T4).

[0137] FIG. 10 is a flowchart illustrating a sample separation method according to one embodiment of the present invention.

[0138] Referring to FIGS. 1 to 10, the sample separator (100, 200) may include a blade module (100). The blade module (100) may partition a sample block (1000).

[0139] The sample separator (100, 200) may include a frame module (200). The frame module (200) may be coupled to the blade module (100). For example, the frame module (200) may be detachably coupled to the blade module (100). The frame module (200) may be seated in a mold (20).

[0140] The sample separation method (S10) may include a sample partitioning step (S100). In step (S100), the sample separator (100, 200) may partition the sample block (1000). For example, the blade module (100) may partition the sample block (1000) in step (S100).

[0141] The sample partitioning step (S100) may include a partition line setting step (S110). In step (S110), at least one partition line may be formed on a sample block (1000) containing a plurality of samples (T1, T2, T3, T4). For example, in step (S110), at least one partition line may be formed on the upper surface of the sample block (1000).

[0142] For example, at least one partition line may be a line formed on the upper surface of the sample block (1000). For example, at least one partition line may indicate a position on the upper surface of the sample block (1000) where at least one blade module (100) is to be inserted. For example, at least one blade module (100) may descend above at least one partition line.

[0143] The sample compartment step (S100) may include a step (S120) of coupling the blade module (100) to the frame module (200). In step (S120), the blade module (100) may be coupled to the frame module (200).

[0144] For example, the base fixer (120b) may be coupled to at least one of the base frame coupler (220b) and the side frame coupler (220s). For example, the side fixer (120s) may be coupled to the side frame coupler (220s).

[0145] The sample compartment step (S100) may include a step (S130) of inserting the blade (110) into the sample block (1000). In step (S130), the blade (110) may be lowered from above the compartment line and inserted into the sample block (1000).

[0146] The step (S130) of inserting the blade (110) into the sample block (1000) can be performed, for example, after the step (S120) in which the blade module (100) is coupled to the frame module (S120).

[0147] The step (S130) of inserting the blade (110) into the sample block (1000) may, for example, be performed prior to the step (S120) of joining the blade module (100) to the frame module (S120).

[0148] The sample separation method (S10) may include a step (S200) of placing a sample block (1000) in a mold (20). In step (S200), the sample block (1000) may be received in the mold body (21) of the mold (20).

[0149] With the sample block (1000) seated in the mold (20), for example, the frame module (200) can be positioned on the bottom surface of the mold body (21). That is, with the sample block (1000) seated in the mold (20), the frame module (200) can be accommodated in the mold (20).

[0150] In another example, with the sample block (1000) seated in the mold (20), the frame module (200) may be seated or mounted on the mold wing (22). In this case, the blade top edge (112t) may face the bottom surface of the mold body (21).

[0151] The sample separation method (S10) may include a step (S300) of heating the mold (20). In this step (S300), the mold (20) may be heated. When the mold (20) is heated, the temperature of the sample block (1000) may rise.

[0152] When the temperature of the sample block (1000) rises, the state of the paraffin contained in the sample block (1000) may change from a solid state to a liquid state. Even if the state of the paraffin contained in the sample block (1000) is liquid, multiple samples (T1, T2, T3, T4) may be kept separated from each other by at least one blade (110). Multiple samples (T1, T2, T3, T4) may be separated from the paraffin contained in the sample block (1000).

[0153] Some or other embodiments of the present invention described above are not exclusive or distinct from one another. Some or other embodiments of the present invention described above may be used in combination or combined, with their respective components or functions.

[0154] It is obvious to those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit and essential features of the invention. The foregoing detailed description should not be interpreted restrictively in any respect and should be considered exemplary. The scope of the invention shall be determined by a reasonable interpretation of the appended claims, and all modifications within the equivalent scope of the invention are included within the scope of the invention.

[0155] [Explanation of the symbol]

[0156] 100: Blade Module 110: Blade

[0157] 120: Fixer 200: Frame Module

[0158] 210: Frame bar 220: Frame coupler

[0159] 230: Frame coupler

Claims

1. A blade extending longitudinally from the first blade side edge and continuing to the second blade side edge; and A base fixer comprising a base fixer body that extends in the above longitudinal direction and is coupled to the blade, and The blade base edge forming the lower end of the blade extends in the longitudinal direction from the lower end of the first blade side edge and connects to the lower end of the second blade side edge and is coupled to the base fixer body, and The upper surface of the above base fixer body is connected to the blade, Sample separator.

2. In Paragraph 1, The thickness of the above blade is, Getting smaller as it goes upward from the blade base edge, Sample separator.

3. In Paragraph 1, The above base fixer is, Further comprising a fixer wing extending from the base fixer body in the thickness direction of the blade, Sample separator.

4. In Paragraph 1, The above base fixer is, A first fixer wing extending from the base fixer body in the thickness direction of the blade and adjacent to the first blade side edge; and Further comprising a second fixer wing extending from the base fixer body in the thickness direction of the blade and adjacent to the second blade side edge, Sample separator.

5. In Paragraph 1, At least one blade module each comprising the blade and the base fixer; and A frame module further comprising a frame module coupled to the base fixer above. Sample separator.

6. In Paragraph 5, The above frame module is, A first frame bar and a second frame bar that extend in one direction and face each other; A plurality of first frame couplers formed on the first frame bar; and It includes a plurality of second frame couplers formed on the second frame bar, and The above base fixer is, A first base fixer coupler coupled to one of the plurality of first frame couplers; and A second base fixer coupler coupled to one of the plurality of second frame couplers, Sample separator.

7. In Paragraph 6, The above-mentioned first base fixer coupler is, It protrudes downward from the lower surface of the base fixer body and is adjacent to the first blade side edge, The above-mentioned second base fixer coupler is, Protruding downward from the lower surface of the base fixer body and adjacent to the second blade side edge, Sample separator.

8. In Paragraph 5, The above frame module is, A first frame bar and a second frame bar, each extending in one direction and having inner surfaces facing each other; A plurality of first frame couplers formed concavely on the inner surface of the first frame bar; and It includes a plurality of second frame couplers formed concavely on the inner surface of the second frame bar, and One end of the base fixer body is coupled to one of the plurality of first frame couplers, and The other end of the base fixer body is coupled to one of the plurality of second frame couplers, Sample separator.

9. Includes at least one blade module and a frame module coupled to said at least one blade module, and The above frame module is, A first frame bar and a second frame bar that extend in one direction and face each other; A plurality of first side frame couplers formed on the first frame bar; and It includes a plurality of second side frame couplers formed on the second frame bar, and Each of the above-mentioned at least one blade module is, A blade extending longitudinally from the first blade side edge and continuing to the second blade side edge; A first side fixer coupler fixed to the first blade side edge and coupled to one of the plurality of first side frame couplers; and A second side fixer coupler coupled to the second blade side edge and coupled to one of the plurality of second side frame couplers, Sample separator.

10. In Paragraph 9, Each of the above plurality of first side frame couplers is, A sunken shape is formed on the upper and inner surfaces of the first frame bar, and Each of the above plurality of second side frame couplers is, A shape formed by a depression on the upper and inner surfaces of the second frame bar. Sample separator.

11. A step (S100) in which at least one blade module partitions a sample block in which a wax-type medium forms a shape that encloses a plurality of samples; Step of placing the above sample block into a mold (S200); and A method comprising the step (S300) of heating the above mold Sample separation method (S10).

12. In Paragraph 11, The above partitioning step (S100) is, Step of setting a partition line on the upper surface of the above sample block (S110); A step of combining at least one blade module to a frame module (S120); and The method includes the step (S130) in which at least one blade module descends from above the partition line and is inserted into the sample block. Sample separation method (S10).

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