Functional health food composition and method for producing same

Abstract

The present invention relates to a functional health food composition used to treat or to maintain and improve the health of patients, and a method for producing same. The functional health food composition of the present invention comprises: an antioxidant component having antioxidant index of a set value or greater; a trace amount of at least one from among vitamins, minerals, and amino acids; and a dietary supplement comprising a hydrolyzed compound extracted from plants.

Description

Health functional food composition and method of manufacturing the same

[0001] The present invention relates to a health functional food, and more particularly to a composition of a health functional food used as a healing food for patients or for maintaining and improving health, and a method for manufacturing the same.

[0002] Most therapeutic patient meals are in the form of a mixed powder of agricultural products such as grains and vegetables, or in the form of porridge with specific foods added. For example, an anti-diabetic patient diet using silkworms (Korean Patent Application 10-2003-0079237), a patient nutritional diet containing dietary fiber for diarrhea patients (Korean Patent Application 10-2013-0073211), a raw food-based nutritional diet for cancer patients made by Tokyo-drying agricultural products and herb powders (Korean Patent Application 10-2023-0112300), a patient meal replacement mixed with grains, agricultural products, herb powders, and minerals (Korean Patent Application 10-2023-0112288), an immune-enhancing composition for patient diet mixed with minerals, etc., including protein, fish oil, and shiitake mushroom extract (Korean Patent Application 10-2016-0091145), porridge made by adding clams to grains (Korean Patent 10-1823265), and a nutritional diet using insects such as mealworms (Korean Patent Application There are 10-2020-0028746) etc.

[0003] As for therapeutic foods, Korean Patent Application 10-2005-0108423 (Prevention or treatment for arthritis) presents a food and food additive for the prevention and treatment of arthritis using a sweet potato (Hydrangeae Dulcis Folium) extract. Korean Patent Application 10-1997-0703101 (Therapeutic food composition and method for reducing blood sugar fluctuations) presents a therapeutic food using complex carbohydrates that are slowly absorbed or digested to reduce blood sugar fluctuations and prevent hypoglycemic episodes.

[0004] Korean Patent Application 10-2003-0014087 (Bladder function improving agent or urinary disorder treatment agent, and food for improving bladder function or treating urinary disorder) describes a therapeutic food by adding Astragalus extract, which is effective for bladder urination, and specific dihydroflavonols, etc., to general food. Korean Patent Application 10-2017-0110076 (Lactic acid bacteria, natural immune activator derived from said lactic acid bacteria, preventive treatment for infectious diseases and food product) presents a food containing lactic acid bacteria.

[0005] As such, therapeutic foods are prepared by adding specific ingredients to food. Alternatively, therapeutic foods are intended to be consumed in pharmaceutical formulations, such as capsules, tablets, or liquids, containing hydrolyzed plant compounds, vitamins, minerals, amino acids, and antioxidant supplements, either individually or in combinations. In other words, conventional therapeutic foods have the problem of being limited in their ingredients and types.

[0006] The present invention was devised in consideration of the above points, and aims to provide a health functional food for healing and a method for manufacturing the same, designed to be consumed as food by selectively combining a food group selected from foods rich in micronutrients, a food group with a high antioxidant index, and various functional foods, including natural dietary supplements.

[0007] The technical problems to be solved by the present invention are not limited to those mentioned above, and other technical problems not mentioned will be clearly understood by those skilled in the art to which the present invention belongs from the description below.

[0008] A health functional food composition according to the present invention for achieving the above objective comprises an antioxidant component having an antioxidant index of a specific value or higher; a trace component comprising at least one of vitamins, minerals, and amino acids; and a dietary supplement comprising a hydrolyzed compound extracted from plants.

[0009] A method for preparing a health functional food composition according to the present invention comprises the steps of: preparing an antioxidant component having an antioxidant index greater than or equal to a specific value; preparing a trace component comprising at least one of a vitamin, a mineral, and an amino acid; preparing a dietary supplement comprising a hydrolyzed compound extracted from a plant; and mixing the antioxidant component, the trace component, and the dietary supplement.

[0010] The health functional food composition according to the present invention is manufactured by selecting and combining ideal foods through scientific analysis, thereby completing the ancient concept of "food as medicine," where food serves as medicine. Accordingly, the health functional food composition of the present invention is a complex therapeutic food or health functional food composition for numerous elderly people suffering from chronic diseases known as modern diseases or concerned about their health, as well as for young people struggling with obesity and those with a meat-heavy diet. Currently, the market for dietary therapy and supplements is reaching trillions of won along with the increase in the elderly population. Furthermore, the importance of the present invention is expanding from a preventive medical perspective that improves the physical, economic, and quality of life, and the market is considered limitless.

[0011] Furthermore, the health functional food composition of the present invention consists of necessary micronutrients and antioxidant foods that eliminate oxidative stress, allowing it to maintain health while being low in calories; thus, it can serve as an excellent healing food even for obese individuals who are most vulnerable in an era of nutritional saturation.

[0012] Figure 1 is a diagram showing the structure of fucoidan.

[0013] Figure 2 is a diagram showing the structure of resveratrol.

[0014] Figure 3 is a diagram showing the structure of curcumin.

[0015] Figure 4 is a diagram showing the structure of sulforaphane.

[0016] Figure 5 is a diagram showing the antioxidant capacity of dietary supplements containing hydrolyzed plant compounds of the present invention as experimental values.

[0017] Figure 6 is a diagram showing the total polyphenol content included in the healing food or health functional food composition of the present invention.

[0018] Figure 7 is a figure showing a comparison of the antioxidant efficacy of ascorbic acid (vitamin C), blueberries, fucoidan, and the healing food or health functional food composition of the present invention.

[0019] Figures 8 to 10 are drawings showing three anti-inflammatory efficacy evaluation indices of the healing food of the present invention.

[0020] FIGS. 11 to 14 are drawings showing the immune index through various inflammatory responses of the healing food of the present invention.

[0021] FIG. 15 is a diagram showing the sequence of preparing the healing food or health functional food composition of the present invention.

[0022] The embodiments disclosed in this specification will be described in detail with reference to the attached drawings, provided that identical or similar components are given the same reference number regardless of the drawing symbols, and redundant descriptions thereof will be omitted. Furthermore, the attached drawings are intended only to facilitate understanding of the embodiments disclosed in this specification, and the technical concept disclosed in this specification is not limited by the attached drawings; it should be understood that the drawings include all modifications, equivalents, and substitutions that fall within the spirit and technical scope of the invention.

[0023] First, the concepts of healing and healing food, which are terms used in this invention, are defined.

[0024] The term "healing" used in this invention must be defined based on the content throughout the invention. It goes without saying that healing cannot be defined by confusing it with the term "treatment." Healing and treatment are scientifically distinct; therefore, healing food is a food for natural healing that embodies the concept of homeostasis, intended to "recover to a healthy state" by enhancing the body's inherent defense system—namely, the immune system—so that it can fight and overcome disease on its own. In contrast, since it is a different concept from medical food designed for the medical treatment of specific diseases, healing food should not be interpreted as medical food.

[0025] Modern medicine has focused solely on the short-term alleviation of symptoms through pharmaceuticals, rarely addressing the underlying etiological processes of disease at the individual level. However, plant-derived bioactive compounds have already provided the basis for the concept of "healing food" as a means of integrating medicine and food, by allowing humans to experience their effects as potential health healers.

[0026] Foods contain various pharmaceutical components, and these components are essential ingredients for pharmaceuticals. Some plant-derived bioactive compounds are being proposed as therapeutic solutions to combat widespread chronic diseases. Furthermore, most synthetic drugs are derived from natural products of pharmaceutical plant origin. This description is intended to explain the background of the present invention and does not limit the scope of the invention. Additionally, the specific forms, materials, or manufacturing processes described in the claims or specification of the present invention are not limited or restricted.

[0027] Since ancient times, it has been recognized that plant-based foods are sources of bioactive compounds possessing excellent pharmacological effects, low toxicity, and minimal side effects. Consequently, both Chinese and Korean medicine have experienced the medical benefits of treating diseases and reducing toxicity by combining specific proportions of foods and herbs. The *Donguibogam* establishes the basis for the principle that food and medicine are one; the *Huangdi Neijing* of China asserts that food and medicine are interconnected; and Indian Ayurvedic medicine states that food heals both the body and the mind. Hippocrates, the great physician of ancient Greece, famously said, "Let your food be your medicine." While the East and West have developed this concept of "food and medicine being one" with their distinct cultural and historical backgrounds, there have been limitations in scientifically analyzing it to realize foods that truly act as medicine. The best approach for health is to follow a diet composed of diverse foods that are nutrient-rich and possess medicinal properties. This constitutes a network of foods. Nothing can deny or replace this.

[0028] Accordingly, the healing food or health functional food composition of the present invention realizes the concept that food becomes medicine by scientifically analyzing the concept of "food and medicine as one," which has been a consistently raised topic, and based on the fundamental principles of food selection and combination regarding "what and how to eat." This principle is characterized by a food mixing system manufactured to maximize synergy resulting from interactions between various nutrients found in diverse foods, rather than a single food or a single specific compound (Moslem Sabaghi ​​et., al. Food and Bioprocess Technology. Volume 15, pages 2422-2455, (2022)). Health can be improved by consuming sufficient fiber and various fruits and vegetables of diverse colors and types (Monique Richard, MS), and by adding specific foods and concentrated plant compounds to the diet (Mir Ali, MD, Orange Coast Medical Center).

[0029] In healing foods, trace elements are more important than macronutrients in an era of nutritional saturation; attention must be paid to antioxidant foods, given that over 90% of modern diseases are caused by free radicals (free radical theory); and the diverse mechanisms of functional dietary supplements are also necessary elements. The effects of the healing food of this invention cannot be replicated by the addition of only one or two specific foods. Since a diet consists of nutritional components that form the large puzzle of overall health, balance is crucial, especially for trace elements. No matter how good a food may be, one cannot survive on just one or two foods alone.

[0030] According to Liebig's Law of the Minimum, if even a single essential nutrient is deficient, health adjusts to that missing nutrient; supplementing it further is futile and only exacerbates side effects. The mechanisms by which modern chronic diseases develop and grow involve hundreds of diverse pathways, much like different DNA sequences. Since genetic factors, environmental pollution, stress, diet, and poor lifestyle habits disrupt the homeostatic balance that sustains health, and the factors of their onset, progression, and growth are all distinct, it is difficult to expect effective results from a single supplement, medication, or food.

[0031] Reactive oxygen species are substances that oxidize proteins, lipids, and nucleic acids within cells, destroying normal cells and damaging DNA to accelerate aging and cause various metabolic diseases such as cardiovascular disease, cancer, and diabetes.

[0032] Even among foods containing pharmaceutical ingredients, their mechanisms of action differ. Therefore, if various foods are selected, combined, and networked, there are many cases where a greater healing effect is obtained due to their interaction (Vi Lien Yap et al., 2023; BMC Complement Med Ther). Thus, the gist of the present invention is to provide a complex effect that aids in healing, alleviates side effects of treatment, and improves the patient's quality of life, which can be obtained by consuming this as a highly efficient and convenient food.

[0033] Antioxidants can also respond to oxidative stress through unique mechanisms of action that perform antioxidant functions in different ways, so networking them can yield greater healing effects than consuming them individually (Vertuanl et., al. Current Pharmaceutical Design, Volume 10, Number 14, 2004, pp. 1677-1694(18)). Taking only specific antioxidant supplements can disrupt the body's natural signaling pathways and have negative effects on health. Certain high-dose antioxidant supplements can actually be harmful.

[0034] Various antioxidant foods can increase the absorption or activity of other antioxidant foods. These interactions can produce a more powerful antioxidant effect than when consumed individually. For example, some directly neutralize free radicals, while others act indirectly by enhancing antioxidant enzymes or reducing free radicals in cells. Consuming various types of antioxidant foods allows for a response to diverse types of free radicals, thereby providing a broader protective effect (Igor Otavioet Minatel et., al; Int. J. Mol. Sci. 2016, 17(8), 1107). This is due to mutual regulation, which enhances homeostasis. Homeostasis is a regulatory function in which the body's constituent tissues attempt to maintain balance on their own, serving as the power to resist disease and recover despite environmental changes or the influence of physical stress. This is precisely the fundamental principle of the unity of food and medicine, a concept that has been dreamed of for thousands of years.

[0035] Even antioxidant foods do not possess all nutrients in equal measure. There are other foods that contain nutritional components such as minerals, vitamins, and amino acids. Therefore, one must include foods rich in various vitamins such as vitamins A, B complex, C, D, E, and K; macronutrients such as calcium and magnesium; micronutrients such as copper, selenium, and zinc; and essential amino acids. In an era of nutritional overconsumption, foods containing micronutrients are more important than macronutrients such as carbohydrates, proteins, and fats. Accordingly, the superfoods selected for the healing food of this invention include tomatoes, broccoli, mushrooms, turmeric, beets, kale, carrots, pumpkins, onions, oatmeal, seaweed, pepper, cinnamon, ginger, garlic, goji berries, and various other berries. These foods are low in calories and possess nutrients such as vitamins and minerals, as well as high antioxidant capacity. However, they are not limited to these. They encompass nuts, legumes, sprouts, fruits, vegetables, and various herbs that meet the criteria of a superfood.

[0036] Type: Cloves, Ginger, Cinnamon, Pepper, Goji Berry, Aronia mmol / 100g 277.320.3131342516.0

[0037] Nutrition J. 2010:9:3 Monica H Carlsen et.,al.

[0038] Table 1 above shows the antioxidant content of the antioxidant components (herb foods) included in the healing food or health functional food composition of the present invention. Most of these antioxidant foods have a high antioxidant index (ORAC score). Cloves, pepper, cinnamon, ginger, garlic, aronia, goji berries, etc., are of the highest grade. The antioxidant components of the present invention may be composed of materials having an antioxidant index of 16 or higher, preferably 25 or higher.

[0039] Vitamin A, Vitamins B1–B12, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Carrot, Goji berry, Tomato, Broccoli, Pumpkin, Broccoli, Nuts, Oatmeal, Onion, Spinach, Kale, Tomato, Cabbage, Kale, Spinach, Sun-dried Shiitake Mushroom, Broccoli, Berries, Butternut Squash, Kale, Butternut Squash, Berries, Tomato, Broccoli

[0040] Table 2 above shows the vitamins and vitamin-containing foods included in the healing food or health functional food composition of the present invention. These correspond to the micronutrient components of the present invention.

[0041] The healing food or health functional food composition of the present invention comprises a functional dietary supplement containing a hydrolyzed extract. The functional dietary supplement of the present invention is composed of hydrolyzed plant compounds and includes at least one of curcumin extracted from turmeric, fucoidan and fucoxanthin extracted from seaweed, sulforaphan extracted from broccoli, quercetin extracted from onions, resveratrol extracted from grapes, and catechin extracted from green tea. Other functional dietary supplements containing hydrolyzed plant compounds may also be included in the healing food or health functional food composition of the present invention.

[0042] In addition, the healing food or health functional food composition of the present invention may further include a natural food that doubles the effects of the present invention, comprising at least one of the following: a food material having physiological activity, for example, lactic acid bacteria, post-bio, yeast, mycelium of mushrooms, or herbal medicine, depending on the specific embodiment.

[0043] In the examples above, the healing food or health functional food composition of the present invention can be modified into various forms of customized food according to the consumer's health or nutritional status or preference, provided that the effects of the present invention are not compromised, and provided as food in various formulations.

[0044] In addition, protein foods, carbohydrate foods, and fat foods can be supplemented to the healing food or health functional food composition of the present invention according to the nutritional needs of the consumer to enhance nutrition and palatability.

[0045] Furthermore, the healing food or health functional food composition of the present invention is prepared by combining hydrolyzed plant compounds, and if the plant compounds are known health functional foods, it can be labeled as a healing food having a functional regulatory effect. For example, the healing food or health functional food composition of the present invention can be labeled as an antioxidant food, or as a health food having an immune function regulating effect.

[0046] The antioxidant foods included in the healing food or health functional food composition of the present invention are described as follows.

[0047] Cloves possess exceptional antioxidant capabilities. Thanks to various antioxidant components, including eugenol, they have powerful antioxidant properties and offer a wide range of health benefits, such as anti-inflammatory, antibacterial, digestive health improvement, anticancer, and immune system enhancement. They are used not only in traditional medicine but also in various dishes and consumed as tea.

[0048] Ginger is a natural antibiotic spice containing gingerol. It possesses powerful anti-inflammatory and antioxidant properties that help reduce oxidative stress and can alleviate nausea in cachexia patients. Additionally, it has antibacterial functions capable of effectively inhibiting various bacteria.

[0049] Pepper contains piperine, a component that stimulates taste buds and promotes the secretion of digestive juices. This piperine lowers the incidence of skin cancer and increases the absorption rate of nutrients found in foods, such as vitamins A, C, and K, as well as B1, B2, B9, calcium, and copper. Curcumin stimulates the sense of taste, and there are research papers indicating that it can increase the absorption rate of curcumin supplements by up to 2,000 times. The piperine in pepper binds to these supplements, increasing their solubility and water-soluble properties. It also temporarily opens the intestinal barrier to make it easier to penetrate cell membranes, thereby allowing macromolecular substances to easily enter the bloodstream and facilitate absorption.

[0050] Cinnamon possesses antioxidant power second only to cloves. Bioactive compounds, including cinnamaldehyde, enhance the ability of insulin to connect with cells and have the efficacy of reducing inflammation. When used in combination and networked, they can influence various inflammatory pathways, which may aid in the prevention and management of chronic diseases. Furthermore, various antioxidants can enhance each other's antioxidant effects by working together.

[0051] Aronia (Chokeberry) possesses high antioxidant capacity due to its diverse antioxidant properties, including anthocyanins, polyphenols, and flavonoids. This contributes to reducing oxidative stress, preventing cell damage, delaying aging, and suppressing inflammation. It is beneficial for cardiovascular health, offers anticancer effects, strengthens immunity, and contains lutein and zeaxanthin, making it a good substance for eye health. Aronia contains approximately 630 mg of anthocyanin per 100g, which is about four times that of acai berries and blueberries, and about twelve times that of cherries. It also contains about 3.7 times that of blueberries, 1.6 times that of acai berries, and about eight times that of raspberries, as well as 'polyphenols,' which are excellent for antioxidant activity.

[0052] The superfoods included in the healing food or health functional food composition of the present invention are described as follows.

[0053] Superfoods are defined as foods that have beneficial effects on health and disease prevention. Superfoods are foods containing minerals, vitamins, trace minerals, and various plant compounds.

[0054] Spinach and kale are green and yellow vegetables; one cup of spinach contains only 6.9 calories and, due to its iron and calcium content, is an invaluable addition to diets free of dairy or meat. It is a superfood rich in nutrients such as vitamins and minerals like Vitamin K, Vitamin A, Vitamin C, magnesium, iron, and calcium, as well as dietary fiber and folic acid. It also contains sulfone compounds called glucosinolates, making it an anti-cancer, anti-inflammatory, and antioxidant superfood. Vitamin K is essential for a healthy body and strong bones because it enhances calcium absorption.

[0055] Oatmeal is low in fat and free from harmful substances such as lactose, cholesterol, and saturated fat, while being rich in nutrients including calcium, iron, vitamin D, vitamin A, vitamin B, essential amino acids, and beta-glucan. It is one of the top 10 superfoods, containing three times the protein of brown rice but only half the calories. However, it is not limited to oat milk. It can be substituted with other seeds, such as almond milk, barley milk, soy milk, and chia seed milk.

[0056] Broccoli is a very healthy vegetable belonging to the cruciferous family, along with cabbage, kale, and cauliflower. One cup of boiled broccoli contains only 30.9 calories, the entire daily requirement of Vitamin K, and double the daily recommended intake of Vitamin C. According to the National Cancer Institute, animal studies have shown that certain chemicals found in cruciferous vegetables, called indole and isothiocyanates, can inhibit the development of cancer in various organs, including the bladder, breast, liver, and stomach. These compounds may protect cells from DNA damage, inactivate carcinogens, and exhibit anti-inflammatory effects.

[0057] Tomatoes are considered a food packed with nutrients, including various minerals such as calcium, phosphorus, iron, potassium, zinc, and copper, as well as vitamins A, B1, B3, B6, C, E, and K, niacin, and folic acid, along with lycopene, beta-carotene, citric acid, malic acid, succinic acid, and lutein. It is a superfood with diverse benefits, including anticancer effects, improved cardiovascular health and vision, enhanced digestive function, and diabetes management. In particular, lycopene is a beneficial component that is recommended by doctors for conditions such as prostate cancer.

[0058] Shiitake Mushrooms: Sun-dried shiitake mushrooms are a treasure trove of Vitamin D. When exposed to the sun for one hour, the Vitamin D2 content increased 24-fold from an initial 0.50 μg (20 IU) to 12.20 μg (488 IU), and after three hours, it increased 27-fold to 13.70 μg (548 IU). This is because ergosterol within the mushrooms is converted into Vitamin D2, significantly increasing the Vitamin D content (Kobe Pharmaceutical University). Therefore, a single shiitake mushroom dried in the sun for one hour may be sufficient to meet the daily recommended intake of Vitamin D. Furthermore, it is rich in beta-glucan and lentinan, an anti-tumor polysaccharide, making it effective for anticancer effects and boosting immunity.

[0059] Seaweeds such as hijiki, kelp, and wakame are organic, natural foods grown solely in seawater—a treasure trove of sunlight and minerals—and contain unrivaled minerals. The minerals found in seaweed are most similar to the minerals that make up about 35% of body weight, and their composition ratios are also similar. These minerals are organic minerals rather than chemical minerals, making them highly absorbable. Furthermore, seaweeds are rich in physiologically active substances such as alginic acid, fucosterol, fucoidan, and fucoxanthin, all of which possess pharmacological effects.

[0060] Falcaninol contained in carrots lowers the incidence of cancer, and beta-carotene exhibits anticancer effects. Additionally, beta-carotene is a precursor to vitamin A and is widely known as an antioxidant superfood containing four times the daily recommended intake of vitamin A for adults.

[0061] Onions contain two powerful antioxidants: sulfur and quercetin. These neutralize free radicals in the body and protect against cell damage, thereby preventing cancer and suppressing inflammatory responses. They are also a superfood containing various nutrients, including magnesium, zinc, selenium, vitamin C, B vitamins, and essential amino acids.

[0062] Butternut squash contains not only vitamins A, B, C, and E, but also Ca, Na, K, Mg, P, Fe, and vitamin 12. It is also a superfood that contains a large amount of phenolic acid, an antioxidant, and has high radical scavenging ability, as well as SOD-like activity and nitrite scavenging action.

[0063] Cabbage is a superfood rich in vitamins K, C, and U, and contains sulfonate compounds called isothiocyanates, which have antioxidant, anticancer, and anti-inflammatory effects.

[0064] Kidney beans are rich in B vitamins, various minerals such as iron and zinc, amino acids, lysine, and folic acid. They strengthen the immune system and are rich in antioxidants such as vitamin A, lutein, and zeaxanthin, which can reduce cell damage and decrease inflammation.

[0065] Beets are a source of 442 mg of potassium, 148 micrograms of folic acid, manganese, vitamin C, and nitrates beneficial for cardiovascular health. The abundant nitrates are good for improving heart health, and an antioxidant called alpha-lipoic acid may be helpful for people with diabetes-related nerve problems called diabetic neuropathy.

[0066] Some of the superfoods of this invention possess high ORAC scores, and others have high-quality nutrition, making them the best foods selected for creating a healing diet that balances nutrition.

[0067] The hydrolysis compound of the dietary supplement included in the healing food or health functional food composition of the present invention and the mechanism of the hydrolysis compound are described as follows.

[0068] Fucoidan is a bioactive substance found in brown algae, such as kelp, a traditional national health food in Japan, and seaweed, a postpartum recovery food that has been passed down in Korea for over a thousand years. In 1991, five institutions, including the Russian Far East Preventive Medicine Centre, recognized fucoidan as a therapeutic food after five years of experimentation. In Japan, following a research announcement at the Cancer Society in 1996 stating that fucoidan has a cancer cell apoptosis-inducing effect, 90% of its consumption is currently in cancer-related products, including those for cancer patients. It is a bioactive functional food for which tens of thousands of research papers have been published, with approximately 350 papers still being published every month. As shown in Fig. 1, fucoidan is a high molecular weight sulfated polysaccharide with a molecular weight exceeding 200,000. Fucoidan stimulates individual immune cells such as macrophages, T cells, and NK cells, activating immune cell networks to improve immune function (Yuan Lin et al., cancer cell 20, Article number: 154 2020).

[0069] Furthermore, fucoidan exerts anticancer effects by targeting various signaling pathways and molecular mechanisms within malignant cells. The pathways of hydrolyzed plant compounds are powerful candidate substances for producing functional foods and drugs by inhibiting the onset of disease or enhancing therapeutic capabilities (Maria Elena Reyes, Ismael Riquelme et., al. Mar duds:Published: 28 April 2020 Review).

[0070] Fucoidan stimulates the mononuclear phagocyte system and induces dendritic cell activation in adaptive immune responses, thereby promoting tumor-specific Thi responses and activating cytotoxic T lymphocyte responses, resulting in immunomodulatory effects (Qin Li et al. Journal of Functional Foods Volume 103, April 2023, 105486). Additionally, fucoidan induces programmed cancer cell death through both endogenous and exogenous pathways (Junpei Shimabukuro et al. Functional Foods in Health and Disease 2018; 8(4): 242-255).

[0071] Fucoidan stimulates AKT and GSK3β acting on mitochondria by reducing endoplasmic reticulum stress through decreasing levels of TSPO, phosphorylated VDAC, PERK, ATF-6, IRE-1, XBP-1, and TRAF2. All of these effects reduce oxidative stress and ultimately induce apoptosis (Cherifa Slim et al., Phytomedicine Plus, Volume 2, Issue 2, 2).

[0072] Resveratrol is a naturally occurring polyphenol found in grapes, wine, red fruits, and peanuts, which are popular among people worldwide. In particular, resveratrol is the most extensively studied polyphenol and possesses antioxidant properties that play a supporting role in all pathologies based on the excessive production of reactive oxygen species (ROS), such as tumors, inflammation, cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and neurodegenerative diseases. As shown in Figure 2, the chemical formula of resveratrol is C14H12O3, its molecular weight is 228.25, it is produced by stilbene synthase, and it exists as two structural isomers. As a phytoalexin secreted when plants are under stress, it is found in higher quantities in grapes than in other plants because grapes secrete a powerful antimicrobial substance called resveratrol as a defense mechanism when attacked by fungi. It has been reported that resveratrol has a potent anticancer effect by blocking all three stages of carcinogenesis: initiation, promotion, and progression. In addition, it has antiviral and neuroprotective effects. Resveratrol has been shown to exhibit antitumor activity by inhibiting stage 1 enzymes and inducing stage 2 metabolic enzymes, thereby synergistically inhibiting neoplastic carcinogens.

[0073] In addition, the growth-inhibiting, cell cycle-arresting, and apoptosis-inducing roles of resveratrol suggest the potential to use resveratrol for cancer prevention (Massimiliano Berretta et al., Int J Mol Sci. 2020 Apr; 21(8): 2945).

[0074] Resveratrol is recognized as a potent tumor growth inhibitor in various experimental models. Previous studies have established anticancer effects in various cultured tumor cell lines, including colon, breast, prostate, and pancreas (Danielly C. et al., Molecules. 2017 Jun; 22(6): 1014).

[0075] Curcumin is the main component of turmeric (Curcuma longa) and is a food recommended to cancer patients by the MS Anderson Cancer Center. More specifically, curcumin is the representative polyphenol component of turmeric. Turmeric is a representative remedy and food that has been used for centuries as a traditional treatment for diseases in Indian Ayurvedic medicine. As shown in Figure 3, the chemical formula of curcumin is C21H20O6 and its molecular weight is 368.38.

[0076] Curcumin possesses anticancer properties by interacting with immune mediators within the human body to exert immunomodulatory capabilities. Furthermore, research has reported that it exerts various anticancer effects through mechanisms such as blocking apoptosis and inhibiting angiogenesis and tumor activity. Curcumin has been shown to inhibit the initiation, progression, and metastasis of various tumors. These anticancer effects are primarily mediated through the negative regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other oncogenic molecules. Additionally, it inhibits cancer cell proliferation by arresting cancer cells or inducing apoptosis at various stages of the cell cycle (Muthu K. Shanmugam et al., Molecules. 2015 Feb; 20(2): 2728-2769).

[0077] Curcumin is involved in the regulation of cancer cell survival and apoptosis, and TNF-α plays an important role in inflammation and cancer. Two FDA-approved drugs targeting TNF-α are infliximab and adalimumab. These drugs are similar in that they reduce inflammation induced by TNF-α, while curcumin inhibits the production of TNF-α and suppresses the TNF signaling pathway (Noor Hasima et al., Int J Biochem Mol Biol. 2012; 3(4): 328-351).

[0078] Curcumin inhibited TNF-mediated NF-κ activation, and glutathione reversed this inhibition. Similarly, the inhibition of TNF-induced AKT activation by curcumin was also interrupted by glutathione. Curcumin induced the production of reactive oxygen species (ROS) and regulated intracellular GSH levels. Based on these results, curcumin mediates apoptosis and anti-inflammatory activity by regulating the redox state of cells (Santosh K. Sandur et al., Free Radic Biol Med. 2007 Aug 15; 43(4): 568-580).

[0079] Sulforaphane found in broccoli has been found to have functions such as inhibiting free radicals, inducing apoptosis in cancer cells, inhibiting angiogenesis, enhancing immunity, and even suppressing the development of cancer itself. As shown in Figure 4, the molecular formula of sulforaphane is C6H11NOS2 and its molecular weight is 177.29. Dr. Paul Talalay of Johns Hopkins Hospital in the United States was the first to prove the tumor-inhibiting effect of sulforaphane, and since then, it has been recommended as an anticancer food for cancer patients at Johns Hopkins Hospital.

[0080] Sulforaphane has been shown to target several tumor or cancer-related signaling pathways, including Bcl-2, Caspase-3, AKT, NF-κ, and P53 / P27, and inhibit the expression of Cyclin-D1 and cMyc in human ovarian cancer cells. It inhibits human ovarian cancer by regulating apoptosis and proliferation-related signaling pathways and exerting synergistic effects with cisplatin (Shi-Feng Kan et al., Int J Mol Med. 2018 Nov; 42(5): 2447-2458.).

[0081] The anticancer efficacy and mechanism of sulforaphane have been studied in various cancers, including breast cancer, colorectal cancer, leukemia, prostate cancer, and pancreatic cancer. Sulforaphane enhances the anticancer activity of taxanes against triple-negative breast cancer by killing cancer stem cells (Joseph P. Burnett et al., Cancer Lett. 2017 May 28; 394: 52-64.).

[0082] Sulforaphane, in particular, has significant potential for the development of new therapies for the treatment of chronic inflammation and autoimmune diseases due to its role in regulating inflammatory signaling pathways, including NF-κ and inflammasome activation (Katie Treasure et al., Immunology & Cell Biology. Volume 101, Issue 9 October 2023).

[0083] As such, dietary supplements containing hydrolyzed plant compounds possess various physiological functions, including antioxidant activity, enhanced immune function, detoxification, assistance in hormone regulation, delayed aging, and reduction of cellular oxidative damage, as well as anticancer, anti-inflammatory, antibacterial, and antiviral effects; these functional foods are already being consumed by people as supplements. When comparing the ABTS radical scavenging ability of these hydrolyzed compound supplements at a concentration of 100 µg / ml with Vitamin C (ascorbic acid), which is used as a general indicator, the ABTS radical scavenging activity reaches 40% for Vitamin C, 50% for Fucoidan, 80% for Curcumin, 90% for Resveratrol, and 85% for Quercetin. These results indicate that dietary supplements containing hydrolyzed plant compounds are effective antioxidants for eliminating ABTS radicals.

[0084] Figure 5 shows the experimental values ​​of the antioxidant activity of dietary supplements containing vitamin C and hydrolyzed plant compounds. As shown in Figure 5, when comparing the ABTS radical scavenging activity of ascorbic acid (vitamin C), fucoidan, curcumin, resveratrol, and quercetin at a concentration of 100 µg / ml, an average value can be obtained indicating how effectively ABTS radicals can be removed.

[0085] Antioxidant activity using ABTS radicals was measured by modifying the method of Van den Berg et al., utilizing the fact that ABTS free radicals generated by reaction with potassium persulfate are removed by antioxidant substances in the sample, causing the characteristic blue-green color of the radical to fade.

[0086] 7 mM 2,2-azino-bis(3-rthylbenzthiazoline-6-sulfonic acid) (ABTS) and 2.45 mM potassium persulfate were mixed to a final concentration and left in a dark place at room temperature for 24 hours to form ABTS+.., after which it was diluted with distilled water to achieve an absorbance value of 0.9 (±0.1) at 732 nm. 50 µl of Zihaiger medicinal injection solution of various concentrations was added to 950 µl of the diluted ABTS radical solution and mixed; the change in absorbance was measured after 10 minutes, and an equal amount of Trolox was added as a standard substance.

[0087] ABTS scavenging ability (%) = 1 - (Absorbance of treated group / Absorbance of untreated group) × 100

[0088] Item: Fucoidan, Curcumin, Resveratrol, Sulforaphane, Quercetin Mechanism: Anticancer, Anti-inflammatory, Antiviral, Antibacterial, Cardiovascular, Antipyrotic, Gastrointestinal Improvement, Apoptosis Induction, Antithrombotic, Antitumor, Anti-inflammatory, Antibacterial, Cardiovascular Protection, Gastrointestinal Improvement, Anti-aging, Anticancer, Anti-inflammatory, Neuroprotection, Anticancer, Anti-inflammatory, Antioxidant, Vision Improvement, Prostate Cancer, Antioxidant, Antiviral, Anti-inflammatory, Antibacterial, Cardiovascular Protection

[0089] As exemplified in Table 3 above, the healing foods of the present invention select and combine foods that make rice a medicine, thereby forming a nutritional balance and an antioxidant network, and complete a healing food or health functional food composition that scientifically completes the unity of food and medicine.

[0090] Professor Ornish of the University of California, famous for the Ornish Program, and a research team from Tufts University in Massachusetts proved that mixing several teas has a more powerful effect than a single cup of good tea. They stated that while a single food alone cannot reduce the risk of disease, the selection and combination of the right foods can make a meaningful difference in healing. This is known as the synergy effect (TED Talk 2010: Can We Eat to Starve Cancer?).

[0091] The safety of the healing food or health functional food composition of the present invention regarding the intake amount for selected foods has been verified.

[0092] Furthermore, the manufacturing method of the present invention is characterized by combining antioxidant herbal foods, superfoods, and bioactive plant nutrients to produce a thick, spreadable stew-type or freeze-dried powder-type product by cooking the ingredients at a temperature that prevents nutritional loss and mixing them according to the ratio of nutrients. However, the healing food of the present invention is not specifically limited to the thick, spreadable stew-type. Specifically, for example, the freeze-dried powder can be used as a care food for patients who have difficulty swallowing thick beverages or soups. It can also be utilized as a dietary food by highlighting specific nutrients or palatability. Alternatively, it can be made into food in various forms, such as retort pouches, dumplings, sandwich patties, powders, and granules.

[0093] The intake amount of the healing food or health functional food composition of the present invention can be determined based on the consumer's age, health condition, weight, and formulation, using 180g as the basic formulation in the form of a thick spread stew. The intake frequency may be twice a day or at every meal.

[0094] The healing food or health functional food composition of the present invention may be labeled as a food for natural healing that enhances the immune system to help the body fight disease on its own and recover to a healthy state, as an antioxidant network food, as a food that prevents and improves inflammation, and as a food with a balance of micronutrients selected and combined from superfoods.

[0095] Figure 6 and Table 4 show the total polyphenol content included in the healing food or health functional food composition of the present invention. The polyphenol index of the antioxidant component is composed of 2,000 mg / g or more, and it is more preferable to be composed of 2,500 mg / g or more as follows.

[0096] Sample Name Total Polyphenol Content (mg / g) Mean Standard Deviation 1 2 3 Healing Food 2.6 4 4 2.6 9 7 2.6 3 9 2.6 6 0 0.0 32

[0097] The foods used in the healing food or health functional food composition of the present invention possess a high antioxidant index (ORAC score) and are classified as superfoods. Table 5 shows the phytochemicals, which are pigment components of the foods selected for the healing food or health functional food composition of the present invention, and their mechanisms.

[0098] Color | Representative Food Color | Ingredient | Representative Mechanism Red | Tomato | Lycopene, Capsaicin | Prevents oxidative stress and cell damage Green | Broccoli, Kale, Cabbage | Sulforaphane, Chlorophyll | Inhibits apoptosis and cancer cell growth Yellow | Turmeric, Ginger, Carrot, Pumpkin | Curcumin, Beta-carotene | Inhibits apoptosis, anti-inflammatory, and cancer growth Purple | Blueberry, Grape | Resveratrol | Anti-inflammatory and inhibits oxidative stress White | Garlic, Onion | Quercetin, Allicin | Antibacterial, immune-activating, and detoxifies carcinogens Brown | Seaweed (Undaria pinnatifida, Kelp, Hijiki) | Fucoidan, Fucoxanthin | Induces cancer cell apoptosis and activates the immune system

[0099] Consuming vegetables and fruits that are vividly colored and diverse is beneficial to health. Consuming a variety of fruits and vegetables in various colors and types allows for the absorption of more polyphenols that are more beneficial to health (Monique Richard, MS, RDN, LDN).

[0100] Phytochemicals, which are compounds found in plants, vary in efficacy depending on the color of vegetables and fruits. These phenolic compounds help prevent vascular and heart diseases by lowering blood cholesterol levels. Allyl compounds, which are abundant in white vegetables, are effective in lowering blood pressure.

[0101] The healing food or health functional food composition of the present invention comprises one or more superfoods superior to trace elements such as minerals, vitamins, and amino acids. In addition, the healing food or health functional food composition of the present invention comprises a functional dietary supplement composed of a hydrolyzed compound comprising at least one, preferably two or more, of fucoidan, curcumin, resveratrol, sulforaphane, quercetin, fucoxanthin, and catechin. For example, the dietary supplement of the present invention may comprise 100 to 1,000 mg of curcumin, 300 to 1,000 mg of fucoidan, 300 to 1,000 mg of yeast, and 50 to 500 mg of resveratrol.

[0102] Figure 7 shows the antioxidant efficacy of ascorbic acid (vitamin C), blueberries, fucoidan, and the healing food or health functional food composition of the present invention. As shown in Figure 7, it can be seen that the antioxidant efficacy of the healing food or health functional food composition of the present invention is superior to that of the individual foods.

[0103] In modern society, the mechanisms by which chronic diseases develop and progress involve hundreds of diverse pathways, much like different DNA sequences. To block these numerous pathways through which diseases develop and progress, one method is to overcome them by forming a network through the selection and combination of various foods. Inflammation is the most important of our body's defense mechanisms. Inflammation is the origin of disease, and it is a matter of immunity.

[0104] Experimental analysis was conducted to investigate the inflammatory response of the healing food of the present invention. First, the antioxidant capacity was examined. To compare the antioxidant capacity of the healing food with individual antioxidant substances, a low-concentration IC50 μg / ml experiment was performed. It did not lag significantly behind individual antioxidant substances, and the polyphenol content and antioxidant capacity as a food showed high indices (Figs. 6 and 7).

[0105] Figures 8 to 10 show the evaluation indices for the anti-inflammatory efficacy of the healing food of the present invention. As shown in Figures 8 to 10, No assay, IL-6, and PGE2 were experimentally analyzed to evaluate the inflammatory response. The NO assay nitrite concentration (μM) for Group 1 was 0.8 at the no-sample treatment concentration of 0, Group 2 was 7.6 at the sample LPS treatment concentration of 0, Group 3 was 3.4 at 100 µg / ml, Group 4 was 1.2 at 200 µg / ml (LPS+healing food), and Group 5 was 0.7 μM at 300 µg / ml.

[0106] ELISA IL-6 (pg / ml) Group 1 is the control group, Group 2 is the LPS treatment concentration 0, Group 3 is the treatment concentration 100, Group 4 is LPS+healing food 200 µg / ml, and Group 5 is 300 µg / ml; the ELISA IL-6 values ​​are 180 for Group 1, 990 for Group 2, 930 for Group 3, 780 for Group 4, and 600 pg / ml for Group 5.

[0107] Nitric oxide (NO) is an important signaling molecule in inflammatory responses. LPS treatment significantly increased NO production, while Healing food significantly reduced NO production depending on the concentration. At Healing food concentrations of 200 μg / ml and 300 μg / ml, NO production decreased to near-control levels, indicating a potent anti-inflammatory effect.

[0108] PGE2 (pg / ml) levels in Group 2 surged to 3,565 pg / ml after LPS treatment. This indicates that LPS increased inflammatory prostaglandins (PGE2). After Healing food treatment, the PGE2 concentration in Group 3 (100 μg / ml) decreased to 1,705 pg / ml. In Groups 4 (200 μg / ml) and 5 (300 μg / ml), treated with high concentrations of Healing food, PGE2 levels decreased to 987 pg / ml and 883 pg / ml, respectively. This demonstrates that Healing food has an excellent inhibitory effect on PGE2.

[0109] In anti-inflammatory experiments of healing food, the concentrations of NO production, IL-6, and PGE2 were reduced in a concentration-dependent manner, and a distinct anti-inflammatory effect was observed at medium to high concentrations (200 μg / ml or higher). In particular, it exerted a powerful anti-inflammatory effect by inhibiting IL-6 and NO production. Since PGE2 is an inflammatory prostaglandin, healing food inhibits it to the level of the control group, demonstrating a strong anti-inflammatory effect.

[0110] Figures 11 to 14 show the immune index of the healing food of the present invention through the inflammatory response. Experimental analysis results indicate that the healing food is an anti-inflammatory substance with a high immune index, capable of contributing to maintaining stable immune function while effectively regulating the inflammatory response. The NO analysis nitrite concentration (μM) and ELISA IL-6 concentration (pg / ml) in the graphs reflect immune modulation for various treatment groups, including the control group, LPS treatment, and healing food at various concentrations. In particular, the inhibitory effects on NO, IL-6, and PGE2 are prominent at a high concentration of 200 mg. Furthermore, due to its excellent immune-modulating ability, it can be evaluated as a balanced anti-inflammatory and immune-modulating substance that effectively suppresses the inflammatory response without excessive immunosuppression.

[0111] Therefore, the healing food of the present invention proves to be a healing food possessing the most effective function of the principle of food becoming medicine.

[0112] The present invention relates to various functional mechanisms of antioxidant foods and functional supplements of hydrolyzed compounds, and to a healing food and health functional food composition and a method for manufacturing the same, which forms a food network with low-calorie nutritional foods rich in trace elements such as vitamins, minerals, and amino acids to obtain maximum healing effects.

[0113] As illustrated in FIG. 15, the method for preparing a healing food and health functional food composition of the present invention comprises the steps of: preparing an antioxidant component having an antioxidant index greater than or equal to a specific value (S11); preparing a trace component including at least one of vitamins, minerals, and amino acids (S12); preparing a dietary supplement containing a hydrolyzed compound extracted from plants (S13); and mixing the antioxidant component, the trace component, and the dietary supplement (S14).

[0114] Example 1

[0115] a. Mix 2% by weight of cloves, 8% by weight of raw ginger, 7% by weight of cinnamon, 8% by weight of pepper, 10% by weight of goji berries, and 15% by weight of turmeric in 50% by weight of purified water, then add 30% by weight of purified water, boil until 30% by weight of purified water evaporates, and strain through a sieve to make a spice herb broth (S11).

[0116] b. Make a puree by grinding oatmeal 5, onion 10, seaweed powder 2, tomato 20, carrot 8, cabbage 7, kale 5, beet 6, garlic 3, shiitake mushroom 3, pumpkin 7, apple 8, and chokeberry 6 in a weight percentage ratio in spice herb broth (S11),

[0117] c. Cut equal amounts of soaked shiitake mushrooms, beets, carrots, cabbage, broccoli, and apples into cubes of 5-10 mm size, and steam soaked peas as they are and freeze-dry them (S12).

[0118] d. To the puree of b, thoroughly mix 100 mg of curcumin, 1,000 mg of fucoidan, 1,000 mg of yeast, 50 mg of resveratrol, and 15 mg of black pepper powder, boil at 90 ℃ or higher for at least 30 minutes to sterilize, and when the moisture reaches 80% (S13)

[0119] e. First, place 10g of freeze-dried vegetables into a 180ml packaging container (S14),

[0120] f. The boiling puree is poured into a packaging container, filled, and sealed to complete the spread stew-type healing food or health functional food composition of the present invention (S14).

[0121] Example 2

[0122] A dry healing food or health functional food composition is completed by freeze-drying the superfood freeze-dried in Example 1c and the puree sterilized by boiling for 30 minutes or more.

[0123] Example 3

[0124] 50% by weight of purified water is mixed with 2% by weight of cloves, 8% by weight of raw ginger, 7% by weight of cinnamon, 8% by weight of pepper, 10% by weight of goji berries, and 15% by weight of turmeric, then 30% by weight of purified water is added and boiled until 30% by weight of purified water evaporates, and strained to make a spice herb broth (S11).

[0125] A puree is made by grinding oatmeal 5, onion 10, seaweed powder 2, tomato 20, carrot 8, cabbage 7, kale 5, beet 6, garlic 3, shiitake mushroom 3, pumpkin 7, apple 8, and chokeberry 6 in a weight percentage ratio in spice herb broth 10 (S12), and

[0126] 15 mg of black pepper powder is thoroughly mixed with a dietary supplement containing 100 mg of curcumin, 1,000 mg of fucoidan, 1,000 mg of yeast, and 50 mg of resveratrol in a puree (S13, S14), boiled at 90 ℃ or higher for 30 minutes or more to sterilize, and then freeze-dried to complete a healing food or health functional food composition in the form of powder or granules.

[0127] The healing food of the present invention is a food composed entirely of pure natural vegan ingredients, and it is a healing food that demonstrates the principle of food and medicine as one, providing nutritional balance to people who enjoy only junk food or meat, as well as to elderly people who are losing their health, thereby protecting their health and helping to prevent and heal diseases.

[0128] The present invention is not limited by the embodiments described above and the attached drawings, and various modifications and applications not exemplified are possible within the scope of the technical concept of the present invention, as well as substitutions of components and changes to equivalent other embodiments are possible; therefore, content related to modifications and applications of the features of the present invention should be interpreted as being included within the scope of the present invention.

Claims

1. An antioxidant component having an antioxidant index greater than a specific value; Trace components comprising at least one of vitamins, minerals, and amino acids; A health functional food composition characterized by comprising a dietary supplement containing a hydrolyzed compound extracted from plants.

2. In Paragraph 1, A health functional food composition characterized by the polyphenol index of the above-mentioned antioxidant component being 2,000 mg / g or higher.

3. In Paragraph 1, The above antioxidant component is, Herb broth in the ratio of 50 wt% purified water, 2 wt% cloves, 8 wt% ginger, 7 wt% cinnamon, 8 wt% black pepper, 10 wt% goji berries, and 15 wt% turmeric; A health functional food composition characterized by comprising, in addition to 10% by weight of the above-mentioned herb broth, 5% by weight of oatmeal, 10% by weight of onion, 2% by weight of seaweed powder, 20% by weight of tomato, 8% by weight of carrot, 7% by weight of cabbage, 5% by weight of kale, 6% by weight of beet, 3% by weight of garlic, 3% by weight of shiitake mushroom, 7% by weight of butternut squash, 8% by weight of apple, and 6% by weight of chokeberry.

4. In Paragraph 3, A health functional food composition characterized by comprising 100~1,000 mg of curcumin, 300~1,000 mg of fucoidan, 300~1,000 mg of yeast, and 50~500 mg of resveratrol.

5. In Paragraph 1, The above dietary supplement is, A health functional food composition characterized by comprising a sulfate or sulfone compound extracted by hydrolyzing a plant.

6. In Paragraph 1, The above dietary supplement is, A health functional food composition characterized by comprising at least two types selected from curcumin extracted from turmeric, sulforaphane extracted from broccoli, fucoidan and fucoxanthin extracted from seaweed, quercetin extracted from onions, resveratrol extracted from grapes, and catechin extracted from green tea, and pepper.

7. A step of preparing an antioxidant component having an antioxidant index greater than a specific value; A step of preparing a trace component containing at least one of vitamins, minerals, and amino acids; Step of preparing a dietary supplement containing hydrolyzed compounds extracted from plants; A method for manufacturing a health functional food characterized by including the step of mixing the above-mentioned antioxidant component, the above-mentioned trace component, and the above-mentioned dietary supplement.

8. In Paragraph 7, A method for manufacturing a health functional food characterized by the above-mentioned antioxidant component having a polyphenol index of 2,000 mg / g or higher.

9. In Paragraph 7, The step of preparing the above antioxidant component is, A step of preparing a herb broth in the ratio of 50% by weight of purified water, 2% by weight of cloves, 8% by weight of ginger, 7% by weight of cinnamon, 8% by weight of pepper, 10% by weight of goji berries, and 15% by weight of turmeric; A method for manufacturing a health functional food, characterized by including the step of making a puree by mixing 5% by weight of oatmeal, 10% by weight of onion, 2% by weight of seaweed powder, 20% by weight of tomato, 8% by weight of carrot, 7% by weight of cabbage, 5% by weight of kale, 6% by weight of beet, 3% by weight of garlic, 3% by weight of shiitake mushroom, 7% by weight of butternut squash, 8% by weight of apple, and 6% by weight of chokeberry with 10% by weight of the above herb broth.

10. In Paragraph 7, The step of preparing the above dietary supplement is, A method for manufacturing a health functional food characterized by including the step of mixing 100~1,000 mg of curcumin, 300~1,000 mg of fucoidan, 300~1,000 mg of yeast, and 50~500 mg of resveratrol.

11. In Paragraph 7, The step of preparing the above dietary supplement is, A method for manufacturing a health functional food characterized by including the step of mixing pepper with at least two types selected from curcumin extracted from turmeric, sulforaphane extracted from broccoli, fucoidan and fucoxanthin extracted from seaweed, quercetin extracted from onions, resveratrol extracted from grapes, and catechin extracted from green tea.

12. In Paragraph 7 The step of preparing the above dietary supplement is, A method for manufacturing a health functional food characterized by including a step of hydrolyzing a plant to extract a sulfate or sulfone compound.

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