Cosmetic composition having stable high content of pure vitamin c through self-stabilization and preparation method thereof

Abstract

The present invention relates to an oil-in-water type liquid cosmetic composition having a high content of vitamin C and having improved formulation stability and feeling of use. The cosmetic composition according to the present invention comprises a high content of vitamin C, a derivative of vitamin C, an emulsifier, and a thickener, and is prepared by a method for achieving a stable formulation even under conditions of low viscosity and pH. Accordingly, it is possible to achieve a high content of vitamin C without precipitation, and simultaneously improve feeling of use and prevent oxidation in a cosmetic.

Description

Cosmetic composition stably containing a high content of pure vitamin C through self-stabilization and method for preparing the same

[0001] This patent application claims priority to Korean Patent Application No. 10-2024-0170454 filed with the Korean Intellectual Property Office on November 26, 2024, and the disclosures of said patent application are incorporated herein by reference.

[0002] The present invention relates to a liquid cosmetic composition containing a high content of vitamin C, and more specifically, to an oil-in-water type liquid cosmetic composition that contains a high content of vitamin C to secure the efficacy of vitamin C while improving formulation stability and usability.

[0003] Vitamin C (ascorbic acid) is widely known as a powerful antioxidant that plays a crucial role in skin health and boosting immunity. It is used as a key ingredient in many cosmetics and health supplements, and notably helps to even out skin tone and alleviate pigmentation such as melasma, freckles, and age spots by inhibiting melanin production. High-concentration Vitamin C products are popular among consumers because they can provide these whitening effects more potently.

[0004] However, there are several issues with using pure Vitamin C in cosmetics. Although Vitamin C is a water-soluble component that can dissolve in water, there is a limit to its solubility, making it difficult to dissolve high concentrations. While raising the temperature can temporarily dissolve high concentrations of Vitamin C to increase solubility, solubility decreases over time and exposure to low-temperature environments, which can lead to the precipitation of Vitamin C powder.

[0005] Another problem with Vitamin C is its sensitivity to oxidation. Oxidation occurs easily immediately after manufacturing, which can lead to stability issues, such as a decrease in efficacy. For this reason, refrigeration is often recommended for high-concentration Vitamin C products to prevent oxidation; however, exposure to low temperatures reduces Vitamin C's solubility, increasing the likelihood of precipitation. This issue negatively impacts not only product efficacy but also consumer satisfaction.

[0006] Another issue when using high concentrations of Vitamin C is the texture of the formulation. When using formulations containing high concentrations of Vitamin C in powder form, stickiness can occur, which significantly impacts the user experience. This stickiness is particularly pronounced in water-based formulations, which can lead to mixed opinions among consumers. To address this, some products have attempted to reduce stickiness and provide a smooth, soft feel by adding oil to create oil-in-water (O / W) formulations. However, Vitamin C has a very low pH and tends to reduce the viscosity of formulations, making it difficult to maintain stability in an O / W system. Consequently, when high concentrations of Vitamin C are applied to low-viscosity liquid formulations, the emulsion becomes unstable over time, potentially leading to galling or separation of the oil phase. To resolve these issues, new methods are required to enhance the solubility and stability of Vitamin C.

[0007] Against this backdrop, the inventors have invented an oil-in-water type liquid cosmetic composition that contains a high content of vitamin C while improving formulation stability and usability.

[0008] The cosmetic composition according to the present invention is prepared by a method that achieves a stable formulation even under conditions of low viscosity and pH. This enables the application of a high concentration of Vitamin C without precipitation, and simultaneously improves the usability of the cosmetic and prevents oxidation.

[0009] The present invention relates to a liquid cosmetic composition containing a high content of vitamin C. In this case, the cosmetic composition of the present invention may have the effects of reducing stickiness, alleviating gelling, alleviating oil phase separation, and preventing vitamin C precipitation.

[0010] The present invention will be described in more detail below.

[0011] One aspect of the present invention is vitamin C (ascorbic acid);

[0012] The present invention relates to a liquid cosmetic composition comprising a derivative of vitamin C including 3-O-ethyl ascorbic acid.

[0013] In the present invention, the vitamin C comprises 10 to 40 wt%, 12 to 40 wt%, 14 to 40 wt%, 16 to 40 wt%, 18 to 40 wt%, 20 to 40 wt%, 10 to 36 wt%, 12 to 36 wt%, 14 to 36 wt%, 16 to 36 wt%, 18 to 36 wt%, 20 to 36 wt%, 10 to 34 wt%, 12 to 34 wt%, 14 to 34 wt%, 16 to 34 wt%, 18 to 34 wt%, 20 to 34 wt%, 10 to 32 wt%, 12 to 32 wt%, 14 to 32 wt%, 16 to 32 wt%, 18 to 32 wt%, 20 to It may include 32 wt%, 10 to 30 wt%, 12 to 30 wt%, 14 to 30 wt%, 16 to 30 wt%, 18 to 30 wt%, 20 to 30 wt%, 10 to 28 wt%, 12 to 28 wt%, 14 to 28 wt%, 16 to 28 wt%, 18 to 28 wt%, 20 to 28 wt%, 18 to 25 wt%, 20 to 25 wt%, 18 to 22 wt%, 20 to 22 wt%, 24 to 30 wt%, 26 to 30 wt%, 24 to 28 wt%, 26 to 28 wt%, for example, 21 wt% or 27 wt%, but is not limited thereto.

[0014] In the present invention, the vitamin C derivative comprises, based on the total composition, 0.5 to 3 wt%, 0.8 to 3 wt%, 1 to 3 wt%, 1.2 to 3 wt%, 1.4 to 3 wt%, 1.6 to 3 wt%, 1.8 to 3 wt%, 0.5 to 2.8 wt%, 0.8 to 2.8 wt%, 1 to 2.8 wt%, 1.2 to 2.8 wt%, 1.4 to 2.8 wt%, 1.6 to 2.8 wt%, 1.8 to 2.8 wt%, 0.5 to 2.6 wt%, 0.8 to 2.6 wt%, 1 to 2.6 wt%, 1.2 to 2.6 wt%, 1.4 to 2.6 wt%, 1.6 to 2.6 wt%, and 1.8 to 2.6 wt%. It may include 0.5 to 2.4 wt%, 0.8 to 2.4 wt%, 1 to 2.4 wt%, 1.2 to 2.4 wt%, 1.4 to 2.4 wt%, 1.6 to 2.4 wt%, 1.8 to 2.4 wt%, 0.5 to 2.2 wt%, 0.8 to 2.2 wt%, 1 to 2.2 wt%, 1.2 to 2.2 wt%, 1.4 to 2.2 wt%, 1.6 to 2.2 wt%, 1.8 to 2.2 wt%, for example, 2 wt%, but is not limited thereto.

[0015] In the present invention, the liquid cosmetic composition may further include an emulsifier, but is not limited thereto.

[0016] In the present invention, the emulsifier may comprise one or more selected from the group consisting of isostearyl alcohol, butylene glycol cocoate, ethylcellulose, C12-16 alcohol, palmitic acid, and hydrogenated lecithin, but is not limited thereto.

[0017] In the present invention, the emulsifier comprises 0.1 to 3 wt%, 0.3 to 3 wt%, 0.5 to 3 wt%, 0.8 to 3 wt%, 1 to 3 wt%, 1.2 to 3 wt%, 1.4 to 3 wt%, 0.1 to 2.5 wt%, 0.3 to 2.5 wt%, 0.5 to 2.5 wt%, 0.8 to 2.5 wt%, 1 to 2.5 wt%, 1.2 to 2.5 wt%, 1.4 to 2.5 wt%, 0.1 to 2.2 wt%, 0.3 to 2.2 wt%, 0.5 to 2.2 wt%, 0.8 to 2.2 wt%, 1 to 2.2 wt%, 1.2 to 2.2 wt%, and 1.4 to 2.2 wt% based on the total composition. It may include 0.1 to 2 wt%, 0.3 to 2 wt%, 0.5 to 2 wt%, 0.8 to 2 wt%, 1 to 2 wt%, 1.2 to 2 wt%, 1.4 to 2 wt%, 0.1 to 1.8 wt%, 0.3 to 1.8 wt%, 0.5 to 1.8 wt%, 0.8 to 1.8 wt%, 1 to 1.8 wt%, 1.2 to 1.8 wt%, 1.4 to 1.8 wt%, 0.1 to 1.6 wt%, 0.3 to 1.6 wt%, 0.5 to 1.6 wt%, 0.8 to 1.6 wt%, 1 to 1.6 wt%, 1.2 to 1.6 wt%, 1.4 to 1.6 wt%, for example, 1.5 wt%, It is not limited to this.

[0018] In the present invention, the liquid cosmetic composition may further include a thickening agent, but is not limited thereto.

[0019] In the present invention, the thickening agent may comprise one or more selected from the group consisting of microcrystalline cellulose, Sphingomonas fermentation extract, cellulose gum, ethyl cellulose, and xanthan gum, but is not limited thereto.

[0020] In the present invention, the thickening agent comprises, based on the total composition, 0.05 to 0.5 wt%, 0.08 to 0.5 wt%, 0.1 to 0.5 wt%, 0.12 to 0.5 wt%, 0.14 to 0.5 wt%, 0.05 to 0.4 wt%, 0.08 to 0.4 wt%, 0.1 to 0.4 wt%, 0.12 to 0.4 wt%, 0.14 to 0.4 wt%, 0.05 to 0.3 wt%, 0.08 to 0.3 wt%, 0.1 to 0.3 wt%, 0.12 to 0.3 wt%, 0.14 to 0.3 wt%, 0.05 to 0.2 wt%, 0.08 to 0.2 wt%, 0.1 to 0.2 wt%, and 0.12 wt%. It may contain up to 0.2% by weight, 0.14% to 0.2% by weight, for example, 0.14% by weight, but is not limited thereto.

[0021] In the present invention, the liquid cosmetic composition may further include, but is not limited to, one or more oils selected from the group consisting of dimethicone, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, and hydrolyzed jojoba ester.

[0022] In the present invention, the oil may be included in an amount of 1 to 10 weight%, 2 to 10 weight%, 4 to 10 weight%, 1 to 8 weight%, 2 to 8 weight%, 4 to 8 weight%, 1 to 6 weight%, 2 to 6 weight%, 4 to 6 weight%, 1 to 5 weight%, 2 to 5 weight%, 4 to 5 weight%, for example, 4 weight%, but is not limited thereto.

[0023] In the present invention, the liquid cosmetic composition may further include one or more selected from the group consisting of polyols, preservatives, neutralizing agents, and antioxidants, but is not limited thereto.

[0024] In the present invention, the polyol may comprise one or more selected from the group consisting of propanediol, dipropylene glycol, glycerin, butylene glycol, diglycerin, 1,2-hexanediol, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, D-panthenol, and octanediol, but is not limited thereto.

[0025] In the present invention, the preservative may comprise one or more selected from the group consisting of 1,2-hexanediol, ethylhexylglycerin, pentylene glycol, benzyl alcohol, chlorphenesin, benzoic acid, sorbic acid, dihydroacetic acid, methylchloroisothiazole, methylisothiazolinone, imidazolidinyl urea, and triclosan, but is not limited thereto.

[0026] In the present invention, the neutralizing agent may comprise one or more selected from the group consisting of tromethamine, arginine, potassium hydroxide, sodium hydroxide, triethanolamine and aminomethylpropanediol, L-arginine, sodium hydroxide and sodium citrate, but is not limited thereto.

[0027] In the present invention, the antioxidant may include one or more selected from the group consisting of tocopherol, broccoli extract, turmeric root extract, spotted pineapple extract, ferulic acid, glutathione, and glucosylrutin, but is not limited thereto.

[0028] In the present invention, the liquid cosmetic composition may comprise one or more selected from the group consisting of purified water, a moisturizer, a chelating agent, an irritation-reducing agent, a wrinkle-improving functional ingredient, a skin conditioning agent, a surfactant, and ethanol, but is not limited thereto.

[0029] In the present invention, the moisturizer may comprise one or more selected from the group consisting of panthenol, methylpropanediol, glycerin, beta-glucan, propanediol, and glycerin, but is not limited thereto. The moisturizer may have the function of adding and retaining moisture to the area to which it is applied.

[0030] In the present invention, the chelating agent may include one or more selected from the group consisting of sodium phytate, sodium EDTA, sodium citrate and sodium metaphosphate, but is not limited thereto.

[0031] In the present invention, the irritant may include one or more selected from the group consisting of allantoin, caffeine, and dipotassium glycyrrhizate, but is not limited thereto.

[0032] In the present invention, the wrinkle-improving functional ingredient may include adenosine, but is not limited thereto.

[0033] In the present invention, the skin conditioning agent may include isostearyl alcohol, but is not limited thereto.

[0034] In the present invention, the surfactant may comprise one or more selected from hydrogenated lecithin or polyglyceryl-10 oleate, but is not limited thereto.

[0035] In the present invention, the ethanol may include denatured alcohol, but is not limited thereto.

[0036] In the present invention, the liquid cosmetic composition may be in any one of the following formulations: an aqueous type, an anhydrous type, and a solubilized type, but is not limited thereto.

[0037] In the present invention, the cosmetic composition may further include one or more additives selected from the group consisting of pigments, preservatives, and fragrances, but is not limited thereto.

[0038] Another aspect of the present invention relates to a method for manufacturing the liquid cosmetic composition.

[0039] Another aspect of the present invention relates to a skin makeup method comprising the following steps:

[0040] A step of applying the cosmetic composition according to the present invention to the skin.

[0041] In the present invention, the pH of the aqueous phase water is not limited.

[0042] Specifically, the cosmetic composition of the present invention includes formulations of skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisture cream, hand cream, foundation, essence, nourishing essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, and body cleanser.

[0043] Throughout this specification, materials, methods, and embodiments are merely illustrative and do not limit the invention. To enable the practice of various embodiments of the invention, descriptions of specific terms are provided:

[0044] [Term]

[0045] The term "emulsifier" in this specification refers to a surfactant used to uniformly mix two or more different phases that do not mix, such as water and oil, to form a stable emulsion (emulsion), and may be used to improve the physical stability and homogeneity of a composition containing an emulsifier.

[0046] The term "vitamin C derivative" as used herein refers to a derivative of vitamin C that has been chemically modified to enhance the stability of vitamin C and improve skin absorption. These derivatives provide effects similar to vitamin C while being less sensitive to oxidation, which can extend the efficacy and shelf life of the product.

[0047] The term "thickening agent" as used in this specification refers to an ingredient used in cosmetics or other products to increase viscosity and improve texture, making the product feel smoother to use and helping the contents spread well on and stay on the skin. Thickening agents may generally consist of polymers, natural rubber, or organic polymer compounds.

[0048] The term “gelling” as used in this specification refers to the phenomenon in which a liquid changes into a semi-solid or solid state to form a gel under certain conditions. This phenomenon may be caused by a thickening agent, a change in temperature, or certain chemical interactions.

[0049] The term "precipitation" as used herein refers to the process in which a component dissolved in a solution separates into a solid form due to reasons such as temperature changes, solvent evaporation, or chemical reactions. Precipitation may occur during the manufacture and storage of cosmetics, pharmaceuticals, or chemical compositions.

[0050] The present invention relates to an oil-in-water type liquid cosmetic composition containing a high content of vitamin C and improving formulation stability and usability.

[0051] The cosmetic composition according to the present invention is prepared by a method comprising a high content of vitamin C, a derivative of vitamin C, an emulsifier, and a thickening agent to achieve a stable formulation even under conditions of low viscosity and pH. This enables the application of a high content of vitamin C without precipitation, and simultaneously improves the usability of the cosmetic and prevents oxidation.

[0052] Figure 1 is a photograph confirming the formulation stability of the composition of Comparative Example 4 after 3 weeks have passed since manufacturing.

[0053] Figure 2 is a photograph confirming the formulation stability of Comparative Example 9 composition after 5 weeks have passed since manufacturing.

[0054] Figure 3 is a photograph confirming the formulation stability of the compositions of Examples 1, 2, and 3.

[0055] Figure 4 is a photograph confirming the formulation stability of the composition of Example 3 after one month has elapsed since manufacturing.

[0056] Figure 5 is a photograph showing the results of vitamin C precipitation after 3 days of freezing (-20℃) storage of the compositions of Example 3 and Comparative Example 19.

[0057] Figure 6 is a photograph showing the results of vitamin C precipitation after one month of storage of the composition of Example 4 under light conditions, low temperature (4°C), room temperature (RT), and high temperature (45°C) in sequence.

[0058] Figure 7 is a photograph showing the results of vitamin C precipitation after one month of storage of the composition of Comparative Example 20 in order under light conditions, low temperature (4℃), room temperature (RT), and high temperature (45℃).

[0059] Figure 8 is a photograph showing the results of vitamin C precipitation after 3 days of storage of the composition of Comparative Example 21 in order under freezing (-20℃), light conditions, low temperature (4℃), room temperature (RT), and high temperature (45℃).

[0060] Figure 9 is a photograph showing the results of vitamin C precipitation after one month of storage of the composition of Comparative Example 22 in order under light conditions, low temperature (4℃), room temperature (RT), and high temperature (45℃).

[0061] Figure 10 is a photograph showing the result of vitamin C precipitation after 1 month of storage at low temperature (4℃) of the composition of Comparative Example 22.

[0062] Figure 11 is a photograph showing the results of vitamin C precipitation after one month of storage of the composition of Example 5 in order under light conditions, low temperature (4°C), room temperature (RT), and high temperature (45°C).

[0063] Figure 12 is a photograph showing the results of vitamin C precipitation after 3 days of freezing (-20℃) storage of the compositions of Example 5 and Comparative Example 22.

[0064] The present invention will be explained in detail below through experimental examples.

[0065] Throughout this specification, when a part is described as "comprising" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0066] Additionally, where numerical ranges are disclosed in this specification, such ranges are continuous and, unless otherwise specified, include all values ​​from the minimum value of such range up to the maximum value including the maximum value.

[0067] Throughout this specification, "%" used to indicate the concentration of a particular substance is (weight / weight)% for solid / solid, (weight / volume)% for solid / liquid, and (volume / volume)% for liquid / liquid, unless otherwise noted.

[0068] Furthermore, the term “or” in this specification is intended to mean an implied “or” rather than an exclusive “or.” That is, where the combination or use of the configurations is not otherwise specified or is not evident from the context, i.e., where X includes A; where X includes B; or where X includes both A and B, “X includes A or B” may be applied to either of these cases.

[0069] Experimental Example 1. Experiment on the improvement of stickiness of high-vitamin C formulations according to oil type (comparison experiment of user sensation)

[0070] A comparative experiment was conducted to improve the sticky texture characteristic of vitamin C powder when containing a high amount of pure vitamin C. The compositions of Comparative Examples 1 to 4 used in the experiment are shown in Table 1.

[0071] Name of Ingredient (INCI) Content (Weight%) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 A Tablet Water Tablet Water To 100 To 100 To 100 To 100 Moisturizer Panthenol 2222 Glycerin 1.5 1.5 1.5 1.5 Methylpropanediol 1.5 1.5 1.5 1.5 Thickening Agent Microcrystalline Cellulose 0.09 0.09 0.09 0.09 Sphingomonas Ferment Extract 0.04 0.04 0.04 0.04 Cellulose Gum 0.01 0.01 0.01 0.01 Chelating Agent Sodium Phytate 0.01 0.01 0.01 0.01 Soothing Agent Allantoin 0.05 0.05 0.05 0.05 Caffeine 0.05 0.05 0.05 0.05 Dipotassium Glycyrrhizate 0.03 0.03 0.03 0.03 Anti-wrinkle Functional Active Ingredient Adenosine 0.04 0.04 0.04 0.04 Humidifier Glycerin 0.1 0.1 0.1 0.1 Beta-glucan 0.00 20.00 20.00 20.00 2 Emulsifier Sodium dilaumidoglutamide lysine 0.03 0.03 0.03 0.03 Preservative 1,2-Hexanediol 2222 Humidifier Hydrolyzed Jojoba Ester 0.4 0.4 B Emulsifier Polyglyceryl-3 Diester Arate 0.40.40.40.4 Glyceryl Stearate Citrate 0.020.020.020.02 Oil Caprylic / Capric Triglyceride 2---Vegetable Oil Hydrogenated Ethylhexyl Oliveate-1.7021.7021.702 Hydrogenated Olive Oil Unsaponifiables-0.2980.2980.298 Silicone Oil Dimethicone---2C Vitamin C Derivative 3-O-Ethyl Ascorbic Acid 2222 Vitamin C Ascorbic Acid 21212121D Neutralizing Agent Tromethamine 2222E Humectant Glycerin 3333 Solubilizer Polyglyceryl-10 Laurate 0.10.10.10.1 Preservative Ethylhexylglycerin 0.05 0.05 0.05 0.05 F Denatured Ethanol 4.75 4.75 4.75 4.75 G Humectant Propanediol 5555 Antioxidant Ferulic Acid 0.5 0.5 0.5 0.5 H Antioxidant Broccoli extract 0.040.040.040.04 Turmeric root extract 0.030.030.030.03 Spotted pineapple extract 0.020.020.020.02 Glucosylrutin 0.10.10.10.1 Moisturizer Glycerin 0.390.390.390.39 Antioxidant Tocopherol 0.10.10.10.1 Surfactant Polyglyceryl-10 Oleate 0.10.10.10.1 Hydrogenated lecithin 0.050.050.050.05.

[0072] The manufacturing process for each composition is as follows.

[0073] Phase A shown in Table 1 was completely dissolved by stirring at 5,000 rpm for 5 minutes at 70°C using a HOMO mixer, and Phase B was dissolved separately at 70°C and added to Phase A. The A+B mixture was emulsified by stirring at 6,000 rpm for 5 minutes using a HOMO mixer, and then cooled to 45°C. Subsequently, Phases C and D were added and stirred at 5,000 rpm for 5 minutes using a HOMO mixer. The solubilizer (polyglyceryl-10 laurate) of Phase E was heated and melted at 45°C or below, mixed with the remaining raw materials, added to the A+B+C+D mixture, and stirred at 5,000 rpm for 3 minutes using a HOMO mixer. Phases F, G, and H were each added and stirred at 5,000 rpm for 3 minutes using a HOMO mixer. Phase G was added after being heated and melted at 80°C. Finally, the composition containing phases A to H was cooled to 30°C.

[0074] 0.5 to 1 g of the prepared compositions of Comparative Examples 1 to 4 were dispensed, gently spread onto the facial skin, and absorbed, and the user's perception of the texture (spreadability, stickiness, moisturizing effect, nourishing effect, etc.) was evaluated. In addition, the formulation stability (whether there was oil phase separation or gelling) of the Comparative Example 4 composition was checked 3 weeks after preparation, and the results are shown in Fig. 1.

[0075] As a result, in the case of the composition of Comparative Example 1 using only caprylic / capric triglyceride, the texture felt somewhat heavy and the stickiness was not improved. In the case of the composition of Comparative Example 2 containing hydrogenated ethylhexyl oliveate and hydrogenated olive oil unsaponifiables, the texture became lighter and the stickiness was partially reduced, but some stickiness remained during rolling of the formulation and after absorption.

[0076] In the case of the composition of Comparative Example 3, which added hydrolyzed jojoba ester to Comparative Example 2, the stickiness was relieved as it was gently absorbed into the skin, but a slight stickiness remained after complete absorption.

[0077] In the case of the composition of Comparative Example 4, which additionally included dimethicone, a silicone oil, in Comparative Example 3, most of the stickiness was improved. However, when more than 3 weeks had passed, the oil phase separated at a high temperature (45℃), and after the high-temperature storage sample was moved to room temperature, the separated oil phase layer gelled and did not dissolve again.

[0078] Experimental Example 2. Comparative experiment for improving gelling phenomenon (stability comparison experiment)

[0079] A comparative experiment was conducted to improve the gelation phenomenon of the separated oil phase of the composition in Experimental Example 1. The compositions of Comparative Examples 5 to 9 used in the experiment are shown in Table 2.

[0080] Purpose of Injection Ingredient Name (INCI) Content (Weight%) Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 A Purification Water Purification Water To 100 To 100 To 100 To 100 To 100 Humidifier Panthenol 2 2 2 2 Glycerin 1.5 1.5 1.5 1.5 1.5 Methylpropanediol 1.5 1.5 1.5 1.5 1.5 Thickener Microcrystalline Cellulose 0.09 0.09 0.09 -0.09 Sphingomonas Ferment Extract 0.04 0.04 0.04 -0.04 Cellulose Gum 0.01 0. 010.01-0.01 Chelating agent Sodium phytate 0.010.010.010.010.01 Irritation reliever Allantoin 0.050.050.050.050.05 Caffeine 0.050.050.050.050.05 Dipotassium glycyrrhizate 0.030.030.030.030.03 Wrinkle improvement Functional Active Ingredient Adenosine 0.040.040.040.040.04 Moisturizer Glycerin 0.10.10.10.10.1 Beta-glucan 0.0020.0020.0020.0020.002 Emulsifier Sodium dilaumidoglutamide lysine 0.030.030.030.030.03 Preservative 1,2-Hexanediol 22222 Moisturizer Hydrolyzed Jojoba Ester 0.40.4 0.40.4B Emulsifier Polyglyceryl-3 Distearate 0.40.40.40.4-Glyceryl Stearate Citrate 0.020.020.020.02-Vegetable Oil Hydrogenated Ethylhexyl Oliveate 1.71.7-1.71.7 Vegetable Oil Hydrogenated Olive Oil Unsaponifiables 0.30.3-0.30.3 Silicone Oil Dimethicone 22222C Vitamin C Derivative 3-O-ethyl ascorbic acid 22222 Vitamin C ascorbic acid 2121212121D Neutralizing agent Tromethamine 22222E Humectant Glycerin 33333 Solubilizer Polyglyceryl-10 laurate 0.10.10.10.10.1 Preservative Ethylhexylglycerin 0.05 0.05 0.05 0.05 0.05 F Denatured alcohol Ethanol 4.75 4.75 4.75 4.75 4.75 G Humectant Propanediol 55555 Antioxidant Ferulic Acid 0.50.50.50.50.5H Antioxidant Broccoli Extract 0.040.040.040.040.040.04 Turmeric Root Extract 0.030.030.030.030.03 Spotted Pineapple Extract 0.020.020.020.020.02 Glucosylrutin 0.10.10.10.10.1 Moisturizer Glycerin 0.39-0.390.390.39 Antioxidant Tocopherol 0.1-0.10.10.1 Surfactant Polyglyceryl-10 Oleate 0.1-0.10.10.1 Surfactant Hydrogenated Lecithin 0.05-0.05 0.05 0.05.05.

[0081] The preparation process for each composition is the same as that of Experimental Example 1. Comparative Examples 5 to 9 were prepared by excluding specific components capable of gelling from the composition of Comparative Example 4. The separation of the oil phase and the gelling phenomenon of the prepared compositions were observed, and the results are shown in Table 3 and Figure 2.

[0082] No. Comparative Example of Oil Phase Separation Gelling Occurrence 5OO Comparative Example 6OO Comparative Example 7OO Comparative Example 8OO Comparative Example 9OX

[0083] As a result, oil phase separation occurred in all Comparative Example 5 (excluding hydrolyzed jojoba ester), Comparative Example 6 (excluding tocopherol), Comparative Example 7 (excluding hydrogenated ethylhexyl oliveate), Comparative Example 8 (excluding microcrystalline cellulose), and Comparative Example 9 (excluding polyglyceryl-3 distearate and glyceryl stearate citrate), but it was confirmed that no gelling occurred in Comparative Example 9 even after 5 weeks.

[0084] Therefore, polyglyceryl-3 distearate and glyceryl stearate citrate were identified as the cause of the gelling phenomenon. In Experimental Example 2, since the pH and viscosity were very low, creating an environment where it is difficult for the oil to be stably dispersed, it was determined that separation of the oil phase occurred at high temperatures, so further experiments were conducted to increase the viscosity of the formulation.

[0085] Experimental Example 3. Comparative experiment for improving high-temperature separation of oil phase and gelling phenomenon

[0086] (1) Comparative experiment based on the type of thickener

[0087] In Experimental Example 2, a comparative experiment was conducted to improve the separation of the oil phase and the gelling phenomenon of the composition at high temperatures. The compositions of Comparative Examples 10 to 14 used in the experiment are shown in Table 4. At this time, the remaining components were kept the same, and only the type and content of the thickener were changed.

[0088] Purpose of Injection Ingredient Name (INCI) Content (Weight%) Comparative Example 10 Comparative Example 11 Comparative Example 12 Comparative Example 13 Comparative Example 14 A Purification Water Purification Water To 100 To 100 To 100 To 100 To 100 Humidifier Panthenol 2 2 2 2 Glycerin 1.5 1.5 1.5 1.5 1.5 Methylpropanediol 1.5 1.5 1.5 1.5 1.5 Thickener Hectorite 0.3 Xanthan Gum 0.3 Microcrystalline Cellulose 0.09 0.09 0.09 -0.18 Sphingomonas Fermentation Extract 0.04 0.04 0.04 -0.04 Cell Lullose gum 0.010.010.01-0.01 chelating agent Sodium phytate 0.010.010.010.01 irritant allantoin 0.050.050.050.050.05 caffeine 0.050.050.050.050.05 dipotassium glycyrrhizate 0.030.030.030.030.03 wrinkle improvement Functional Active Ingredient Adenosine 0.040.040.040.040.04 Moisturizer Glycerin 0.10.10.10.10.1 Beta-glucan 0.0020.0020.0020.0020.002 Emulsifier Sodium dilaumidoglutamide lysine 0.030.030.030.030.03 Preservative 1,2-Hexanediol 22222 Moisturizer Hydrolyzed Jojoba Ester 0.40.40.40.40.4 B Thickener Ammonium polyacryloyldimethyltaurate 0.5----Sodium polyacrylate-- 0.2--Hydrogenated Polydecene--0.2--PPG-5-Laureth-5--0.02--C Emulsifier Polyglyceryl-3 Distearate 0.40.40.40.40.4 Glyceryl Stearate Citrate 0.020.020.020.020.02 Vegetable Oil Hydrogenated Ethylhexyl Oliveate 1.71.71.71.71.7 Vegetable Oil Hydrogenated Olive Oil Unsaponifiables 0.30.30.30.30.3 Silicone Oil Dimethicone 22222D Vitamin C Derivative 3-O-ethyl ascorbic acid 22222 Vitamin C ascorbic acid 2121212121 E Neutralizing agent Tromethamine 22222 F Humectant Glycerin 33333 Solubilizer Polyglyceryl-10 laurate 0.10.10.10.10.1 Preservative Ethylhexylglycerin 0.05 0.05 0.05 0.05 0.05 G Ethanol denatured alcohol 4.75 4.75 4.75 4.75 4.75 H Humectant Propanediol 55555 Antioxidant Ferulic acid 0.5 0.5 0.5 0.50.5I Antioxidant Broccoli Extract 0.040.040.040.040.040.04 Turmeric Root Extract 0.030.030.030.030.03 Spotted Pineapple Extract 0.020.020.020.020.02 Glucosylrutin 0.10.10.10.10.1 Moisturizer Glycerin 0.390.390.390.390.390.39 Antioxidant Tocopherol 0.10.10.10.10.1 Surfactant Polyglyceryl-10 Oleate 0.10.10.10.10.1 Surfactant Hydrogenated Lecithin 0.050.050.050.050.05.05.

[0089] Phase A shown in Table 4 was completely dissolved by stirring at 5,000 rpm for 5 minutes at 70°C using a HOMO mixer, and Phase B was added and emulsified by stirring at 6,000 rpm for 5 minutes using a HOMO mixer. Subsequently, Phase C was dissolved separately at 70°C, added to the A+B phase, and cooled to 45°C. Phases D and E were added and stirred at 5,000 rpm for 5 minutes using a HOMO mixer. The solubilizer for Phase F (polyglyceryl-10 laurate) was heated and melted at 45°C or below, mixed with the remaining raw materials, added to the A+B+C+D+E phase, and stirred at 5,000 rpm for 3 minutes using a HOMO mixer. Phases G, H, and I were each added and stirred at 5,000 rpm for 3 minutes using a HOMO mixer. Phase H was added after being heated and melted at 80°C. Finally, the composition containing phases A to I was cooled to 30°C.

[0090] The compositions of Comparative Examples 10 to 14 were tested for usability in the same manner as in Experimental Example 1, and it was checked whether there was oil phase separation and gelling.

[0091] As a result of the experiment, in the case of Comparative Examples 10, 11, and 12, even though a thickening agent that forms viscosity well at low pH was applied, a large amount of thickening agent had to be added to form slight viscosity. Due to the large amount of thickening agent added, the stickiness of the formulation was somewhat excessive.

[0092] In the case of Comparative Example 13, in which a large amount of thickener was removed, the oil phase separation phenomenon at high temperatures occurred more rapidly starting about 1 week after preparation, and the gelation phenomenon was severe, resulting in poor stability.

[0093] In the case of Comparative Example 14, no high-temperature oil phase separation was observed at week 5 as the viscosity increased slightly. However, it was determined that stability needed to be further improved as the turbidity and viscosity of the formulation gradually increased.

[0094] (2) Comparative experiment based on the type of emulsifier

[0095] In Experimental Example 2, a comparative experiment was conducted to improve the separation of the oil phase and the gelling phenomenon of the composition at high temperatures. The compositions of Comparative Examples 4, 15 to 18, and Example 1 used in the experiment are shown in Table 5. At this time, the remaining components were kept the same, and only the type and content of the emulsifier were changed.

[0096] [Table] Purpose of Injection Ingredient Name (INCI) Content (Weight%) Comparative Example 4 Comparative Example 15 Comparative Example 16 Comparative Example 17 Comparative Example 18 Example 1A Purification Water Purification Water To 100 To 100 To 100 To 100 To 100 To 100 Moisturizer Panthenol 222222 Methylpropanediol 1.5 1.5 1.5 1.5 1.5 1.5 Glycerin 4.5 4.5 4.5 4.5 Thickening Agent Microcrystalline Cellulose 0.09 0.09 0.09 0.09 0.09 0.09 0.09 Sphingomonas Ferment Extract 0.04 0.04 0.04 0.04 0.04 0.04 Cellulose Gum 0.01 0.01 0.010.010.010.01 Chelating agent Sodium phytate 0.010.010.010.010.010.01 Irritation reliever Allantoin 0.050.050.050.050.050.05 Caffeine 0.050.050.050.050.050.050.05 Dipotassium glycyrrhizate 0.030.030.030.030.030.030.03 Wrinkle improvement Functional Active Ingredient: Adenosine 0.04 0.04 0.04 0.04 0.04 0.04 Moisturizer: Beta-glucan 0.002 0.002 0.002 0.002 0.002 0.002 Emulsifier: Sodium dilaumidoglutamide lysine 0.03 0.09 ---- Preservative: 1,2-Hexanediol 2 22222 Moisturizer: Hydrolyzed Jojoba Ester 0.4 0.4 0.4 0.4 0.4 4 B Emulsifier: Polyglyceryl-3 Distearate 0.4 ----- Glyceryl Stearate Citrate 0.02 ----- Cetearyl Oliveate--0.6---Sorbitan Oliveate--0.4---Jojoba Ester---0.15--Glyceryl Stearate---0.15--Cetyl Alcohol---0.13--Stearyl Alcohol---0.13--Sodium Stearyl Glutamate---0.06--Sunflower Seed Wax---0.06--Skin Conditioning Isostearyl Alcohol----0.9 0.6 Emulsifier Butylene Glycol Cocoate----0.5 0.3 Thickening Agent Ethyl Cellulose----0.03 0.02 Emulsifier C12-16 Alcohol-----0.5 Palmitic acid-----0.2 Surfactant Hydrogenated lecithin-----0.2 Vegetable oil Hydrogenated ethylhexyl oliveate 1.7 1.7 1.7 1.7 1.7 1.7 Vegetable oil Hydrogenated olive oil Unsaponifiable matter 0.3 0.3 0.3 0.3 0.30.30.3 Silicone Oil Dimethicone 222222C Vitamin C Derivative 3-O-Ethyl Ascorbic Acid 222222 Vitamin C Ascorbic Acid 212121212121D Neutralizing Agent Tromethamine 222222E Humidifier Glycerin 3-----Solubilizer Polyglyceryl-10 Laurate 0.1-----Preservative Ethylhexylglycerin 0.05 0.05 0.05 0.05 0.05 0.05 F Ethanol Denatured Alcohol 4.75 4.75 4.75 4.75 4.75 4.75 G Humidifier Propanediol 555555 Antioxidant Ferulic Acid 0.5 0.5 0.5 0.5 0.5 0.5 H Antioxidant Broccoli Extract 0.04 0.040 .040.040.040.04 Turmeric Root Extract 0.030.030.030.030.030.03 Spotted Pineapple Extract 0.020.020.020.020.020.02 Glucosylrutin 0.10.10.10.10.10.1 Moisturizer Glycerin 0.39100.10000 Polyglyceryl-10 Oleate 0.10.10.10.10.10.100.1000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000

[0097] The preparation process for each composition is the same as that of Experimental Example 1. In Example 1 and Comparative Examples 15 to 18, polyglyceryl-10 laurate in phase E was excluded from the emulsifier components. The separation of the oil phase and the gelling phenomenon of the prepared compositions were observed.

[0098] As a result of the experiment, high-temperature oil phase separation and gelling occurred in Comparative Example 4, so a different emulsifier was introduced to replace the emulsifier in Comparative Example 4.

[0099] In the case of Comparative Example 15, no gelling occurred, but after 4 weeks, oil phase separation occurred under all storage conditions as well as high temperature, and the oil phase separation was particularly severe at room temperature.

[0100] In the case of Comparative Example 16, after 4 weeks, it was confirmed that the turbidity of the formulation increased under all storage conditions, and gelling occurred, resulting in the formation of small granules on the wall.

[0101] In the case of Comparative Example 17, no separation of the oil phase was observed after 4 weeks, but gelled granules were produced at low temperature (4℃).

[0102] In the case of Comparative Example 18, after 4 weeks, no oil phase separation was observed, but a thin band formed on the wall of the vial was observed.

[0103] In the case of Example 1, no oil phase separation or gelling occurred after 4 weeks. Therefore, it was determined that the emulsifier composition of Example 1, which did not cause the gelling phenomenon that was the most problematic in the formulation, was the optimal combination.

[0104] Additionally, Examples 1 to 3 were prepared with compositions as shown in Table 6 below by varying the emulsifier content.

[0105] Purpose of Injection Ingredient Name (INCI) Content (Weight%) Example 1 Example 2 Example 3 A Purification Agent Water To 100 To 100 To 100 Moisturizer Panthenol 222 Methylpropanediol 1.5 1.5 1.5 Glycerin 4.5 4.5 4.5 Thickener Microcrystalline Cellulose 0.09 0.09 0.09 Sphingomonas Ferment Extract 0.04 0.04 0.04 Cellulose Gum 0.01 0.01 0.01 Chelate Sodium Phytate 0.01 0.01 0.01 Soothing Agent Allantoin 0.05 0.05 0.05 Caffeine 0.05 0.05 0.05 Dipotassium Glycyrrhizate 0.03 0.03 0.03 Anti-wrinkle Functional Active ingredient Adenosine 0.04 0.04 0.04 Moisturizer Beta-glucan 0.00 20.00 20.00 2 Preservative 1,2-Hexanediol 22 2 Moisturizer Hydrolyzed Jojoba Ester 0.4 0.4 0.4 B Skin conditioning 2. Isostearyl alcohol 0.6 0.6 0.6 Emulsifier Butylene glycol cocoate 0.3 0.3 0.3 Thickening agent Ethyl cellulose 0.02 0.02 0.02 Emulsifier C12-16 Alcohol 0.5 0.3 0.2 Palmitic Acid 0.2 0.1 7 0.12 Surfactant Hydrogenated Lecithin 0.2 0.1 4 0.1 Vegetable Oil Hydrogenated Ethylhexyl Oliveate 1.7 1.7 1.7 Hydrogenated Olive Oil Unsaponifiables 0.3 0.3 0.3 Silicone Oil Dimethicone 2 2 2 C Vitamin C Derivative 3-O-Ethyl Ascorbic Acid 222 Vitamin C Ascorbic Acid 212121D Neutralizing Agent Tromethamine 222E Preservative Ethylhexylglycerin 0.05 0.05 0.05 Ethanol Denatured Alcohol 4.75 4.75 4.75F Moisturizer Propanediol 555 Antioxidant Ferulic Acid 0.5 0.5 0.5G Antioxidant Broccoli Extract 0.04 0.040 .04 Turmeric Root Extract 0.03 0.03 0.03 Spotted Pineapple Extract 0.02 0.02 0.02 Glucosylrutin 0.1 0.1 0.1 Moisturizer Glycerin 0.3 9 0.3 9 0.39 Antioxidant Tocopherol 0.1 0.1 0.1 Surfactant Polyglyceryl-10 Oleate 0.1 0.1 0.1 Hydrogenated Lecithin 0.05 0.05 0.05

[0106] Phase A shown in Table 6 was completely dissolved by stirring at 5,000 rpm for 5 minutes at 70°C using a HOMO mixer, and Phase B was dissolved separately at 70°C and added to Phase A. The A+B mixture was emulsified by stirring at 6,000 rpm for 5 minutes using a HOMO mixer, and then cooled to 45°C. Subsequently, Phases C and D were added and stirred at 5,000 rpm for 5 minutes using a HOMO mixer. Phases E, F, and G were each added and stirred at 5,000 rpm for 3 minutes using a HOMO mixer. Phase F was added after being heated and dissolved at 80°C. Finally, the composition containing Phases A to G was cooled to 30°C.

[0107] We checked whether there was a precipitation phenomenon at a low temperature of 4℃, and whether oil phase separation and gelling phenomena occurred after one month, and the results are shown in Figures 3 and 4.

[0108] As a result of the experiment, it was confirmed that all three types of the examples had a low amount of precipitation. In addition, it was confirmed that the composition of Example 1 did not exhibit gelling even after one month.

[0109] Experimental Example 4. Comparative experiment for preventing Vitamin C powder precipitation

[0110] Apart from the above experimental examples, a comparative experiment was conducted to prevent the precipitation of vitamin C powder. It was confirmed that it is applicable in various formulations, and the compositions of Examples 3 to 5 and Comparative Examples 19 to 22 used in the experiment are shown in Table 7.

[0111] Purpose of Injection Ingredient Name (INCI) Content (Weight%) Example 3 Example 4 Example 5 Comparative Example 19 Comparative Example 20 Comparative Example 21 Comparative Example 22 A Purification Water Purification Water To 100 - To 100 To 100 - To 100 To 100 Moisturizer Panthenol 2222222 Propanediol - To 100 - To 100 - Methylpropanediol 1.5 - 1.5 1.5 - 1.5 1.5 Glycerin 4.5 - 4.5 4.5 - 4.5 4.5 Thickening Agent Microcrystalline Cellulose 0.09 - 0.09 - Sphingomonas Ferment Extract 0.04 - 0.04 - 0.04 Cellulose Gum 0.01 - 0.01 0.01 - 0.01 0.01 Neutralizing Agent Tromethamine - 2 - --Chelating agent Sodium Phytate 0.01-0.01 0.01-0.01 0.01 Irritation Soothing agent Allantoin 0.05-0.05 0.05-0.05 0.05 Caffeine 0.05-0.05 0.05-0.05 0.05 Dipotassium Glycyrrhizate 0.03-0.03 0.03-0.03 0.03 Anti-wrinkle functional active ingredient Adenosine 0.04-0.04 0.04-0.04 0.04 Moisturizer Beta-glucan 0.002-0.0020.002-0.0020.002 Preservative 1,2-Hexanediol 2-22-22 Moisturizer Hydrolyzed Jojoba Ester 0.4-0.4---B Skin Conditioning 2. Isostearyl Alcohol 0.6-0.6--- Emulsifier Butylene Glycol Cocoate 0.3-0.3--- Thickening Agent Ethyl Cellulose 0.02-0.02--- Emulsifier C12-16 Alcohol 0.2-0.2--- Palmitic Acid 0.12--0.12--- Surfactant Hydrogenated Lecithin 0.1--0.1--- Vegetable Oil Hydrogenated Ethylhexyl Oliveate 1.7--1.7--- Hydrogenated Olive Oil Unsaponifiables 0.3--0.3--- Silicone Oil Dimethicone 2--2--- Vitamin C Derivative 3-O-Ethyl Ascorbic Acid 222---1 Vitamin C Ascorbic Acid 21202721202727D Neutralizing Agent Tromethamine 2-2.7222.72.7E Preservative Ethylhexylglycerin 0.05--0.05---Ethanol Denatured Alcohol 4.7524.754.7524.754.75F Humidifier Propanediol 5-55-55 Antioxidant Ferulic Acid 0.5-0.50.5-0.50.5G Humidifier Glycerin--3--33 Solubilizer Polyglyceryl-10 Laurate--0.3--0.30.3 Preservative Ethylhexylglycerin--0.05--0.050.05H Antioxidant Broccoli Extract 0.04-0.04 0.04-0.04 0.04 Turmeric Root Extract 0.03-0.03 0.03-0.03 0.03 Spotted Pineapple Extract 0.02-0.02 0.02-0.02 0.02 Glucosylrutin 0.1-0.1 0.1 0.1 Moisturizer Glycerin 0.39-0.39 0.39-0.39 0.39 Antioxidant Tocopherol 0.1-0.1 0.1 0.1 Surfactant Polyglyceryl-10 Oleate 0.1-0.1 0.1 0.1 0.1 Hydrogenated Lecithin 0.05-0.05 0.05-0.05 0.05.

[0112] The manufacturing process for each composition is as follows.

[0113] For the compositions of Example 3 and Comparative Example 19, phase A was stirred at 5,000 rpm for 5 minutes at 70°C using a HOMO mixer, and phase B was stirred at 75°C using an Agi mixer for 5 minutes. Then, phase B was added and stirred at 6,000 rpm for 5 minutes at 70°C, and cooled to 45°C. Phases C, D, E, F, and H were added in sequence, stirred at 5,000 rpm for 3 minutes at 45°C, and then cooled to 30°C.

[0114] The compositions of Example 4 and Comparative Example 20 were prepared by stirring phase A at 5,000 rpm for 10 minutes at 80°C using a HOMO mixer, adding phase C and stirring at 5,000 rpm for 10 minutes at 80°C, cooling to 30°C, adding phase E and stirring at 5,000 rpm for 3 minutes.

[0115] For the compositions of Example 5 and Comparative Examples 21 and 22, phase A was stirred at 5,000 rpm for 5 minutes at 70°C using a HOMO mixer and cooled to 45°C. Then, phase C was added and stirred at 5,000 rpm for 10 minutes at 45°C, and phases D, E, F, G, and H were added in sequence and stirred at 5,000 rpm for 3 minutes at 45°C, and then cooled to 30°C.

[0116] Comparative experiments were conducted on compositions of O / W, non-aqueous, and solubilized types to confirm whether Vitamin C precipitated under various temperature and time conditions.

[0117] The compositions of Example 3 and Comparative Example 19 are compositions having an oil-in-water (O / W) formulation as in Experimental Examples 1 to 3 above, and

[0118] The compositions of Example 4 and Comparative Example 20 are water-free compositions, and

[0119] The compositions of Example 5 and Comparative Examples 21 and 22 are solubilized compositions with a higher vitamin C content. The examples of this experimental example differ from the comparative example compositions in whether a vitamin C derivative is included and in the content of the vitamin C derivative.

[0120] The results of the vitamin C powder precipitation experiments of Examples 3 to 5 and Comparative Examples 19 to 22 were confirmed and are shown in Table 8 and Figures 5 to 10.

[0121] Example 3 Example 4 Example 5 Comparative Example 19 Comparative Example 20 Comparative Example 21 Comparative Example 22 Presence of Vitamin C Precipitation XXXOOOO

[0122] As a result of observing Example 3 and Comparative Example 19, Comparative Example 19, which does not contain a vitamin C derivative, showed vitamin C powder precipitation after 3 days of frozen storage (-20℃), whereas in Example 3, vitamin C powder did not precipitate (Fig. 5).

[0123] As a result of observing Example 4 and Comparative Example 20, Comparative Example 20, which does not contain a vitamin C derivative, showed vitamin C powder precipitation after 1 month of storage under light conditions, low temperature (4℃), room temperature (RT), and high temperature (45℃), whereas in Example 4, vitamin C powder did not precipitate (Figs. 6 and 7).

[0124] As a result of observing Example 5 and Comparative Examples 21 and 22, Comparative Example 21, which does not contain a vitamin C derivative, showed that vitamin C powder precipitated after 3 days of freezing (-20℃ storage) (Fig. 8),

[0125] Comparative Example 22, which contained 50% less vitamin C derivative than Example 5, showed vitamin C powder precipitation after 1 month at low temperature (4℃) and after 3 and 4 days at freezing (-20℃) conditions (Figs. 9, 10 and 12).

[0126] In the case of Example 5, vitamin C powder did not precipitate under light conditions, freezing (-20℃), low temperature (4℃), room temperature (RT), and high temperature (45℃) storage conditions (Figs. 11 and 12).

[0127] Experimental Example 5. Process Titer Analysis Results

[0128] The potency retention rates of the prepared compositions of Examples 3, 4, and 5 were measured after 1, 3, 6, and 12 months at 25°C and are shown in Table 9. An HPLC-DAD analyzer was used as the analytical instrument.

[0129] 1M 3M 6M Example 393.33% 94.04% - Example 495.50% 95.50% 95.30% Example 598.40% 93.18% -

[0130] Potency retention rate = (Analysis content / Input content) × 100

[0131] As a result of the analysis, the compositions of Examples 3 to 5 maintained a high potency retention rate even after a considerable amount of time had passed.

[0132] In the above experimental example, a cosmetic composition was obtained in which the sticky sensation was improved and the layer separation at high temperatures, gelling phenomena, and precipitation phenomena at low temperatures were reduced, even when containing a high amount of vitamin C.

[0133] The scope of protection of the present invention is not limited to the description of the embodiments explicitly explained above. Furthermore, the scope of protection of the present invention cannot be limited by obvious modifications or substitutions in the technical field to which the present invention belongs.

Claims

1. Vitamin C (ascorbic acid); A derivative of vitamin C comprising 3-O-ethyl ascorbic acid; and A liquid cosmetic composition comprising a thickening agent, The above vitamin C is included in an amount of 10 to 40 weight percent relative to the total composition, and The above vitamin C derivative is included in an amount of 0.5 to 3 weight percent relative to the total composition, and A liquid cosmetic composition comprising a thickening agent that includes microcrystalline cellulose and a Sphingomonas fermentation extract.

2. In Paragraph 1, The above liquid cosmetic composition further comprises an emulsifier.

3. In Paragraph 2, A liquid cosmetic composition comprising one or more emulsifiers selected from the group consisting of isostearyl alcohol, butylene glycol cocoate, ethylcellulose, C12-16 alcohol, palmitic acid, and hydrogenated lecithin.

4. In Paragraph 2, A liquid cosmetic composition comprising 0.1 to 3 weight percent of the emulsifier based on the total composition.

5. In Paragraph 1, A liquid cosmetic composition comprising one or more types selected from the group consisting of cellulose gum and ethyl cellulose as the thickening agent.

6. In Paragraph 1, A liquid cosmetic composition comprising 0.05 to 0.5 weight percent of the above-mentioned thickener relative to the total composition.

7. In Paragraph 1, The above liquid cosmetic composition further comprises an oil containing one or more selected from the group consisting of dimethicone, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, and hydrolyzed jojoba ester.

8. In Paragraph 1, The above liquid cosmetic composition further comprises one or more selected from the group consisting of polyols, preservatives, neutralizing agents, and antioxidants.

9. In Paragraph 1, The above liquid cosmetic composition is a liquid cosmetic composition in which the above liquid cosmetic composition is in any one of the following formulations: oil-in-water (O / W), anhydrous, and a solubilized formulation.

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