Filter device for an optical analysis device, and method for operating the optical analysis device

The filter device with dual filter carriers and optimized optical filters addresses the limited optical channels issue, enhancing multiplex analysis by increasing channel count and reducing cross-talk, thereby improving fluorescence detection accuracy in decentralized diagnostics.

WO2026125704A1 Publication Date: 2026-06-18ROBERT BOSCH GMBH
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
ROBERT BOSCH GMBH
Filing Date
2025-12-12
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Existing optical analysis devices for decentralized diagnostics face limitations due to a limited number of optical channels, leading to cross-talk and misinterpretation of emission signals in multiplex assays, especially when combining excitation and emission wavelength bands of different fluorophores.

⚗Method used

A filter device with two filter carriers, each containing specific optical filters, allows for the creation of both diagonal and off-diagonal optical channels, increasing the total number of available channels and reducing cross-talk through the use of bandpass, longpass, and multibandpass filters, along with a compact design using filter slides and a filter wheel.

🎯Benefits of technology

Enhances the number of optical channels, reduces cross-talk, and enables efficient multiplex analysis by allowing selection of multiple wavelength bands, improving the accuracy of fluorescence detection in decentralized diagnostic devices.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to a filter device comprising: a first filter carrier (10) having x first optical filters (11, 12); and a second filter carrier (20) having y second optical filters (21-23), wherein x and y each independently have a value of at least 2, and wherein the filter carriers (10, 20) are each designed such that one filter (11, 12, 21-23) of each filter carrier (10, 20) can be positioned in an optical path of the filter device. Each first optical filter (11, 12) transmits light in a first wavelength band (71, 72), and each second optical filter (21-23) transmits light in x second wavelength bands (81-86), wherein the first wavelength bands (71, 72) do not overlap, the second wavelength bands (81-86) do not overlap, and each first wavelength band (71, 72) contains a second wavelength band (81-86) from each of the second optical filters (21-23). An optical analysis device comprises a light source (41), a sample carrier (42), and an optical sensor (43). The filter device is arranged in an optical path between the light source (41) and the sample carrier (42) and / or in an optical path between the sample carrier (42) and the optical sensor (43). In a method for operating the optical analysis device, a sample (50) is arranged on the sample carrier (42), is excited to fluoresce by means of the light source (41), and light emitted by the sample (50) is detected by the optical sensor (43), wherein a fluorescence analysis of the sample is carried out in x · y optical channels.
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