Neisseria outer membrane vesicles and uses thereof

OMVs from multiple strains of Neisseria gonorrhoeae, with specific protein sequences and genetic modifications, address the limitations of existing treatments by inducing a broad-spectrum immune response against the bacterium, enhancing infection prevention.

WO2026128672A2 Publication Date: 2026-06-18VIBRANT BIOMEDICINES INC
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
VIBRANT BIOMEDICINES INC
Filing Date
2025-12-11
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Current treatments for Neisseria gonorrhoeae infections, including antibiotics and vaccines, are compromised by antimicrobial resistance and lack of clinical efficacy, necessitating a need for alternative therapeutic approaches.

⚗Method used

Compositions comprising outer membrane vesicles (OMVs) from multiple strains of Neisseria gonorrhoeae, with varying protein sequences and genetic modifications, are developed to induce an immune response and provide protection against the bacterium.

🎯Benefits of technology

The OMV compositions effectively stimulate an immune response, offering protection against a wide range of N. gonorrhoeae strains and reducing infection risk in populations.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention features outer membrane vesicles (OMVs), such as native or detergent extracted OMVs from N. gonorrhoeae. For example, the compositions may include OMVs obtained from two or more different gonococcal strains, or OMVs containing different outer membrane proteins and / or lipooligosaccharides (LOS). The invention also provides for genetically modified gonococci as well as immunogenic compositions containing the outer membrane vesicles.
Need to check novelty before this filing date? Find Prior Art