Mass spectrometry analysis system and method for operating mass spectrometry analysis module
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
- Filing Date
- 2025-02-26
- Publication Date
- 2026-06-25
Smart Images
Figure CN2025079196_25062026_PF_FP_ABST
Abstract
Description
Mass spectrometry analysis system and method for running mass spectrometry analysis module Technical Field
[0001] This application relates to the field of mass spectrometry analysis, and in particular to mass spectrometry analysis systems and methods for running mass spectrometry analysis modules. Background Technology
[0002] Existing triple quadrupole mass spectrometers are primarily designed for applications in the scientific instrumentation field. However, due to the broad applicability of scientific instruments, and to meet general needs, the two-stage mass analyzers in existing triple quadrupole mass spectrometers used as scientific instruments typically operate within a specific mass range, such as a specific operating frequency, and the mass ranges, such as operating frequencies, of the two stages are usually the same. This results in the system's performance not being fully utilized in some situations. Summary of the Invention
[0003] In order to at least partially solve the above-mentioned technical problems, the objective of this application is to provide a technical solution that can dynamically adjust the mass range of the first mass analyzer and / or the second mass analyzer during the operation of the mass spectrometry analysis module, thereby enabling different mass ranges to be adapted for different samples, so as to optimize system performance for different samples.
[0004] To address the aforementioned issues, a first aspect of this application provides a mass spectrometry analysis system, comprising a sample information acquisition module, a mass spectrometry analysis module, and a controller. The sample information acquisition module is configured to acquire sample information of a sample. The mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage having a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage having a second operating frequency to be applied to the second mass analyzer.
[0005] The controller is communicatively connected to the sample information acquisition module and the mass spectrometry analysis module and is configured to: acquire first detection item information of the first sample and second detection item information of the second sample from the sample information acquisition module;
[0006] The controller is further configured to: when the first detection item information is different from the second detection item information, adjust the first mass analyzer by adjusting the first operating frequency, such that the mass range of the first mass analyzer is different when the mass spectrometry analysis module is controlling the detection of the first sample compared with the mass range of the first mass analyzer when the mass spectrometry analysis module is controlling the detection of the second sample; and / or, adjust the second mass analyzer by adjusting the second operating frequency, such that the mass range of the second mass analyzer is different when the mass spectrometry analysis module is controlling the detection of the first sample compared with the mass range of the second mass analyzer when the mass spectrometry analysis module is controlling the detection of the second sample.
[0007] In some embodiments, the power supply unit includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate the first DC voltage and the first radio frequency power signal, and the second power supply component is configured to generate the second DC voltage and the second radio frequency power signal.
[0008] In some embodiments, the power supply unit includes a first tuning component and a second tuning component, the first tuning component being configured to tune a first radio frequency power signal to generate the radio frequency voltage having a first operating frequency, and the second tuning component being configured to tune a second radio frequency power signal to generate the radio frequency voltage having a second operating frequency; and the adjustment of the first operating frequency is achieved by adjusting the capacitance and / or inductance of the first tuning component, and / or the adjustment of the second operating frequency is achieved by adjusting the capacitance and / or inductance of the second tuning component.
[0009] In some embodiments, the first operating frequency and / or the second operating frequency are in the range of 500 kHz to 2 MHz.
[0010] In some embodiments, the power supply unit is configured such that the first operating frequency and the second operating frequency can be adjusted independently of each other.
[0011] In some embodiments, the controller includes a memory and a processor, the memory storing a relationship between detection item information and a first operating frequency and / or a relationship between detection item information and a second operating frequency; and adjusting the first operating frequency includes: the processor adjusting the first operating frequency according to the relationship between the detection item information stored in the memory and the first operating frequency, and / or adjusting the second operating frequency includes: the processor adjusting the second operating frequency according to the relationship between the detection item information stored in the memory and the second operating frequency.
[0012] In some embodiments, the relationship between the detection item information and the first operating frequency and / or the relationship between the detection item information and the second operating frequency is stored in the memory in the form of a mapping table.
[0013] In some embodiments, the mass spectrometry analysis system further includes an operation module configured to edit, delete, or add the relationship between the detection item information stored in the memory and the first operating frequency and / or the relationship between the detection item information and the second operating frequency through an operation interface.
[0014] In some embodiments, the sample information acquisition module includes a scanner for scanning the markings on a sample container containing the sample to obtain the test item information of the sample.
[0015] In some embodiments, the sample information acquisition module includes a user interface for receiving detection item information of the sample input by the user.
[0016] In some embodiments, the first sample and the second sample are different samples, or the first sample and the second sample come from the same sample.
[0017] In some embodiments, the mass spectrometry analysis system further includes a pretreatment module and a liquid chromatography module. The controller is also configured to control the pretreatment module to pretreat the first sample and the second sample, control the liquid chromatography module to perform chromatographic separation on the pretreated first sample and the second sample, and control the transfer of the chromatographically separated first sample and the second sample to the mass spectrometry analysis module.
[0018] To address the aforementioned issues, a second aspect of this application provides a mass spectrometry analysis system, comprising:
[0019] The sample information acquisition module is configured to acquire sample information.
[0020] A mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage having a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage having a second operating frequency to be applied to the second mass analyzer.
[0021] The controller, which is communicatively connected to the sample information acquisition module and the mass spectrometry analysis module, is configured to:
[0022] Based on the detection item information of the sample, determine the first operating frequency and / or the second operating frequency that matches the detection item information; and
[0023] When controlling the mass spectrometry analysis module to detect the sample, the first mass analyzer is operated at the first operating frequency and / or the second mass analyzer is operated at the second operating frequency.
[0024] To address the aforementioned issues, a third aspect of this application provides a method for operating a mass spectrometry analysis module, wherein the mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit, the power supply unit being configured to generate a first DC voltage and a radio frequency voltage having a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage having a second operating frequency to be applied to the second mass analyzer, the method comprising:
[0025] Obtain the first detection item information for the first sample and the second detection item information for the second sample.
[0026] When the information of the first detection item is different from the information of the second detection item, the first mass analyzer can be adjusted by adjusting the first operating frequency, so that the mass range of the first mass analyzer when controlling the mass spectrometry analysis module to detect the first sample is different from the mass range of the first mass analyzer when controlling the mass spectrometry analysis module to detect the second sample, and / or, the second mass analyzer can be adjusted by adjusting the second operating frequency, so that the mass range of the second mass analyzer when controlling the mass spectrometry analysis module to detect the first sample is different from the mass range of the second mass analyzer when controlling the mass spectrometry analysis module to detect the second sample.
[0027] In some embodiments, the power supply unit includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate the first DC voltage and the first radio frequency power signal, and the second power supply component is configured to generate the second DC voltage and the second radio frequency power signal.
[0028] In some embodiments, the power supply unit includes a first tuning component and a second tuning component.
[0029] When controlling the mass spectrometry analysis module to detect the first sample or the second sample, the first radio frequency power signal is tuned by the first tuning component to generate the radio frequency voltage with the first operating frequency, and the second radio frequency power signal is tuned by the second tuning component to generate the radio frequency voltage with the second operating frequency; and in the method, the adjustment of the first operating frequency is achieved by adjusting the capacitance and / or inductance of the first tuning component, and / or the adjustment of the second operating frequency is achieved by adjusting the capacitance and / or inductance of the second tuning component.
[0030] In some embodiments, the first operating frequency and / or the first operating frequency is in the range of 500 kHz to 2 MHz; and / or, the first operating frequency and the first operating frequency can be adjusted independently of each other.
[0031] In some embodiments, adjusting the first operating frequency includes adjusting the first operating frequency according to the relationship between pre-stored detection item information and the first operating frequency, and / or adjusting the second operating frequency includes adjusting the second operating frequency according to the relationship between pre-stored detection item information and the second operating frequency.
[0032] In some embodiments, the relationship between the detection item information and the first operating frequency and / or the relationship between the detection item information and the second operating frequency is pre-stored in the form of a mapping table.
[0033] In some embodiments, the relationship between pre-stored detection item information and the first operating frequency and / or the relationship between detection item information and the second operating frequency can be edited, deleted, or added through the user interface.
[0034] In some embodiments, a scanner is used to obtain the sample information for the detection items of the sample.
[0035] In some embodiments, user input is received via a user interface to obtain detection item information for the sample.
[0036] In some embodiments, the first sample and the second sample are different samples, or the first sample and the second sample come from the same sample.
[0037] To address the aforementioned issues, a fourth aspect of this application provides a method for operating a mass spectrometry analysis module, wherein the mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage having a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage having a second operating frequency to be applied to the second mass analyzer. The method includes:
[0038] Obtain the testing information for the sample;
[0039] Based on the detection item information of the sample, determine the first operating frequency and / or the second operating frequency that matches the detection item information; and
[0040] When controlling the mass spectrometry analysis module to detect the sample, the first mass analyzer is operated at the first operating frequency and / or the second mass analyzer is operated at the second operating frequency.
[0041] In the technical solutions proposed in this application, the mass range that the first and / or second mass analyzers should have when performing mass spectrometry detection on the sample is automatically and dynamically adjusted according to the sample information, without user intervention. Specifically, according to the embodiments of this application, for first and second samples with different detection item information, the mass ranges of the first and / or second mass analyzers are different when the mass spectrometry analysis module detects them. This allows for automated optimization of system performance for different samples, especially for automatically improving system response, i.e., system sensitivity, for different samples. Attached Figure Description
[0042] Figure 1 shows a schematic diagram of the structure of a mass spectrometry analysis system according to some embodiments of this application;
[0043] Figure 2 shows a schematic diagram of the structure of a mass spectrometry analysis module according to some embodiments of this application;
[0044] Figure 3 shows images of the quadrupole stable region according to some embodiments of this application;
[0045] Figure 4 shows a graph illustrating the relationship between operating frequency and upper limit of quality range according to some embodiments of this application;
[0046] Figure 5 shows the scanning mass spectrum peaks of the spectral analysis module at different operating frequencies according to some embodiments of this application;
[0047] Figure 6 shows a schematic diagram of the structure of a mass spectrometry analysis module according to some other embodiments of this application;
[0048] Figure 7 shows a flowchart of a method for a motion mass spectrometry analysis module according to some embodiments of this application. Detailed Implementation
[0049] The embodiments of this application will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0050] It should be noted that the terms "first, second, and third" used in the embodiments of this application are merely to distinguish similar objects and do not represent a specific order of objects. It can be understood that "first, second, and third" can be interchanged in a specific order or sequence where permitted.
[0051] Those skilled in the art will understand that, unless otherwise defined, all terms used herein (including technical and scientific terms) have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.
[0052] As mentioned in the background section, existing triple quadrupole mass spectrometers are all designed for applications in the field of scientific instruments, and are set with fixed mass ranges to meet the needs of general use.
[0053] However, in the field of in vitro diagnostics, mass spectrometers are used in medical laboratories to perform mass spectrometry analysis on patient samples. In this scenario, the tests performed are relatively fixed and the types of tests are limited.
[0054] Based on this, the embodiments of this application propose to determine the quality range of the quality analyzer according to sample information, especially the detection item information, and improve system performance, especially system sensitivity, by sacrificing unnecessary quality range.
[0055] Figure 1 shows a schematic diagram of the structure of a mass spectrometry analysis system according to some embodiments of the present application, and Figure 2 shows a schematic diagram of the structure of a mass spectrometry analysis module according to some embodiments of the present application.
[0056] As shown in Figure 1, the mass spectrometry analysis system 100 includes a sample information acquisition module 110, a mass spectrometry analysis module 120, and a controller 130.
[0057] In this embodiment of the application, the sample information acquisition module 110 is configured to acquire sample information of the sample.
[0058] In some embodiments, the sample information may be testing item information, which may include, for example, hormone testing and / or immunosuppressant drug testing. The testing item information may be a single testing item or a combination of at least two testing items. That is, mass spectrometry analysis needs to be performed on the sample for each testing item in the testing item information.
[0059] In some embodiments, the sample information acquisition module 110 may include a scanner for scanning a marking, such as a barcode or QR code, on a sample container containing the sample to obtain sample information, particularly test item information. In other embodiments, the sample information acquisition module 110 may include a user interface for receiving sample information, particularly test item information, input by the user. In still other embodiments, the sample information acquisition module 110 may be a memory communicatively connected to the scanner for receiving and storing sample information, particularly test item information, obtained by the scanner.
[0060] In this embodiment, as shown in FIG2, the mass spectrometry analysis module 120 includes a first mass analyzer 121, a collision cell 122, and a second mass analyzer 123. The collision cell 122 is used to connect the two mass analyzers 121 and 123 in series. In the collision cell, the precursor ion is subjected to high-energy collisions under a neutral gas background to break down or fragment into daughter ions. In application, the first mass analyzer 121 is used to screen the precursor ion. The precursor ion is fragmented into daughter ions by the collision cell 122, and the second mass analyzer 123 screens the daughter ions to facilitate quantitative analysis based on the response of the daughter ions.
[0061] In some embodiments, the mass spectrometry analysis module 120 can be configured as a triple quadrupole mass spectrometer, which typically uses two sets of quadrupole mass analyzers to perform the analysis of substances. Specifically, the first mass analyzer 121 and the second mass analyzer 123 of the mass spectrometry analysis module 120 both consist of four parallel metal rods, i.e., both are quadrupoles. A DC voltage and a radio frequency voltage applied to the metal rods cause ions to move in a helical orbit along the axis between the metal rods. Depending on the voltage applied to the metal rods, ions with a specific m / z value will pass through the quadrupole, while ions with larger or smaller m / z values will fly outwards and cannot pass through the quadrupole.
[0062] In a specific example, as shown in Figure 2, the mass spectrometry analysis module 120 may include an ion source 124, an ion transport section 125, a first mass analyzer 121, a collision cell 122, a second mass analyzer 123, and an ion detector 126 along the ion transport direction. The ion source 124 is used to ionize the sample to generate precursor ions. The ion transport section 125 is used to transport the precursor ions generated by the ion source 121 to the first mass analyzer 121. The first mass analyzer 121 is used to perform mass separation of the incoming precursor ions, or to scan or monitor precursor ions with specific m / z values within a mass range, to screen out predetermined precursor ions. The collision cell 122 is used to cause the predetermined precursor ions screened by the first mass analyzer 121 to undergo collisional fragmentation to generate daughter ions. The second mass analyzer 123 is used to perform mass separation of the daughter ions, or to scan or monitor daughter ions with specific m / z values within a mass range. The ion detector 126 is used to detect the daughter ions output from the second mass analyzer 123. It should be understood that, in the figures, A and B represent electrodes with different polarities.
[0063] In some embodiments, the transport of ions in the mass spectrometry analysis module 120 needs to be carried out under a specific voltage. Therefore, the mass spectrometry analysis module 120 also includes a power supply unit 127, which is used to provide the corresponding voltage for the ion transport section 125, the first mass analyzer 121, the collision cell 122, the second mass analyzer 123, etc.
[0064] In a specific example, power supply unit 127 is configured to generate DC and RF voltages to be applied to the first mass analyzer 121 and DC and RF voltages to be applied to the second mass analyzer 123, so that the respective mass analyzers operate in cooperation with the RF and DC voltages to achieve ion screening and ion transport in the respective mass analyzers.
[0065] Furthermore, the power supply unit 127 is configured to generate an RF voltage to be applied to the ion transport section 125 and the collision cell 122 to enable ion transport in the ion transport section 125 and the collision cell 122.
[0066] It should be noted that, for those skilled in the art, the appropriate structure and working principle of the ion source 124, ion transport section 125, first mass analyzer 121, collision cell 122, second mass analyzer 123, and ion detector 126 of the mass spectrometry analysis module 120 are known, except for the working mode of the first mass analyzer 121 and the second mass analyzer 123, and therefore no particular limitations are imposed here. For example, the ion source 124 can achieve ionization based on the principles of electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), the ion transport section 125 may include a quadrupole, a hexapole, etc., the collision cell 122 may be a linear collision cell or a curved collision cell, the first mass analyzer 121 and the second mass analyzer 123 may be quadrupoles, and these components may be arranged in a vacuum environment, etc., but the embodiments of this application are not limited to these.
[0067] Further discussion of these appropriate structures and operating principles will be limited to discussions relating to the operation of the first mass analyzer 121 and the second mass analyzer 123.
[0068] In this embodiment, the controller 130 is communicatively connected to the sample information acquisition module 110 and the mass spectrometry analysis module 120. For example, the controller 130 is configured to acquire sample information from the sample information acquisition module 110 and control the mass spectrometry analysis module 120 based on the sample information. Specifically, the controller 130 is configured to: determine the mass range of the first mass analyzer 121 and / or the second mass analyzer 123 that matches the sample information; and, when controlling the mass spectrometry analysis module 120 to detect the sample, cause the first mass analyzer 121 and / or the second mass analyzer 123 to operate within the mass range that matches the sample information.
[0069] Therefore, the controller automatically and dynamically adjusts the quality range of the quality analyzer based on the acquired sample information, so that the system performance matches the sample information. That is, it realizes automatic and targeted optimization of system performance without the need for user intervention to manually select the quality range corresponding to the sample information. This not only improves the system detection performance, but also reduces the user's burden and avoids errors caused by the user manually selecting the quality range.
[0070] In a specific example, controller 130 can be configured to: acquire first detection item information of a first sample and second detection item information of a second sample from a sample information acquisition module; when the first detection item information differs from the second detection item information, adjust the first mass analyzer 121 so that the mass range of the first mass analyzer 121 is different when the mass spectrometry analysis module 120 detects the first sample compared to when the mass spectrometry analysis module 120 detects the second sample. In other words, when the first detection item information of the first sample differs from the second detection item information of the second sample, the mass range of the first mass analyzer 121 for the first sample and the second sample is different when the mass spectrometry analysis module 120 performs detection.
[0071] Alternatively or additionally, the controller 130 may also be configured to adjust the mass range of the second mass analyzer 123 such that the mass range of the second mass analyzer 123 is different when the mass spectrometry analysis module 120 is controlling the detection of the first sample compared to when the mass spectrometry analysis module 120 is controlling the detection of the second sample. That is, when the first detection item information of the first sample differs from the second detection item information of the second sample, the mass range of the second mass analyzer 123 for the first and second samples differs when the mass spectrometry analysis module 120 performs the detection.
[0072] In some embodiments, the controller 130 may include a processor and a computer-readable storage medium storing computer-readable instructions that, when executed by the processor, cause the processor to perform corresponding method steps.
[0073] In some embodiments, the processor includes, but is not limited to, devices for interpreting computer instructions and processing data in computer software, such as a central processing unit (CPU), a micro controller unit (MCU), a field-programmable gate array (FPGA), and a digital signal processor (DSP).
[0074] It is understood that the storage medium in the embodiments of this application can be volatile memory or non-volatile memory, or both. Non-volatile memory can be read-only memory, programmable read-only memory, erasable programmable read-only memory, electrically erasable programmable read-only memory, magnetic random access memory, flash memory, magnetic surface memory, optical disk, or read-only optical disk; magnetic surface memory can be disk storage or magnetic tape storage. Volatile memory can be random access memory used as an external cache. By way of example, but not limitation, many forms of RAM are available, such as static random access memory, synchronous static random access memory, dynamic random access memory, synchronous dynamic random access memory, double data rate synchronous dynamic random access memory, enhanced synchronous dynamic random access memory, synchronous linked dynamic random access memory, and direct memory bus random access memory. The memory described in the embodiments of this application is intended to include, but is not limited to, these and any other suitable types of memory.
[0075] The following describes some embodiments for adjusting the operating range using a quadrupole mass analyzer (i.e., both the first and second mass analyzers are quadrupoles) as an example. It should be understood that the embodiments in this application are not limited to quadrupole mass analyzers.
[0076] The quadrupole mass analyzer consists of four cylindrical electrodes (which can be hyperbolic, circular, or square), arranged in pairs, forming two parallel and symmetrical groups (X and Y) about the central axis. The potentials of these two groups differ by 180°. By applying DC and radio frequency voltages to the quadrupole, the trajectory of ions in the X and Y directions is controlled. Only when the movement in both X and Y directions is stable can ions pass through the quadrupole mass analyzer and move backward. Ions whose movement in either the X or Y direction is unstable will gradually break free and collide with the electrodes or fly out of the quadrupole region, ultimately achieving the specific mass analysis function.
[0077] Specifically, within a quadrupole, the trajectory of ions with a specific mass-to-charge ratio is related to the amplitude of the DC voltage applied to the quadrupole, the amplitude of the radio frequency voltage, and the operating frequency of the radio frequency voltage. Figure 3 shows an image of the quadrupole's stable region, where parameter 'a', related to the DC field, is:
[0078] The parameter q related to the exchange field is:
[0079] Where m is the mass of the substance, z is the charge, r0 is the quadrupole field radius, U is the DC voltage amplitude, V is the radio frequency voltage amplitude, and ω is the operating frequency or angular frequency of the radio frequency voltage. Mass analysis control is achieved by controlling the DC and radio frequency on the quadrupole. Ions can only be transmitted backward through the mass analyzer when their parameters a and q are within region 200.
[0080] Therefore, the quality range of the first and / or second quality analyzers can be adjusted by changing the DC voltage amplitude, RF voltage amplitude, and RF voltage operating frequency, so that the quality range matches the sample information.
[0081] In some embodiments, during mass analysis, the operating frequency of the radio frequency (RF) voltage determines the oscillation period of ions moving within the quadrupole mass analyzer. Increasing the RF voltage operating frequency can improve the resolution of the quadrupole mass analyzer, but it will reduce the upper limit of the mass range. For example, increasing the operating frequency will reduce the upper limit of the mass range as shown in the curve in Figure 4. Furthermore, increasing the RF voltage operating frequency can improve the sensitivity of the mass analyzer while maintaining the same resolution. As shown in Figure 5, simulating the mass spectrum peaks appearing after 1000 ions are scanned by the mass analyzer at two operating frequencies: 800 kHz and 1.6 MHz. It can be seen that the intensity of the mass spectrum peak 301 corresponding to the 1.6 MHz frequency scan is significantly higher than that of the mass spectrum peak 302 scanned at 800 kHz. Therefore, during mass analysis, the mass range can be reduced by increasing the operating frequency of the mass analyzer, thereby improving system sensitivity.
[0082] Based on this, the power supply unit 127 of the mass spectrometry analysis module 120 is configured to generate a first DC voltage and an RF voltage with a first operating frequency to be applied to the first mass analyzer 121, and a second DC voltage and an RF voltage with a second operating frequency to be applied to the second mass analyzer 123. Accordingly, the controller 130 is configured to adjust the mass range of the first mass analyzer by adjusting the first operating frequency, and / or adjust the mass range of the second mass analyzer by adjusting the second operating frequency.
[0083] For example, the controller 130 can be configured to: determine a first operating frequency and / or a second operating frequency matching the detection item information of the sample; and, when controlling the mass spectrometry analysis module to detect the sample, to operate the first mass analyzer at the first operating frequency and / or to operate the second mass analyzer at the second operating frequency. Thus, the controller automatically and dynamically adjusts the operating frequency of the mass analyzers based on the acquired detection item information, ensuring that the system performance matches the sample's detection item information. This achieves automatic and targeted optimization of system performance without requiring user intervention to manually select the operating frequency of the mass analyzer corresponding to the detection item information. This not only improves system detection performance but also reduces the user's burden and avoids errors caused by manual selection of the operating frequency.
[0084] In a specific example, controller 130 is configured to: acquire first detection item information of a first sample and second detection item information of a second sample from the sample information acquisition module 110; when the first detection item information is different from the second detection item information, the first mass analyzer 121 can be adjusted by adjusting the first operating frequency so that the mass range of the first mass analyzer 121 when the mass spectrometry analysis module detects the first sample is different from the mass range of the first mass analyzer 121 when the mass spectrometry analysis module detects the second sample, and / or, the mass range of the second mass analyzer 123 can be adjusted by adjusting the second operating frequency so that the mass range of the second mass analyzer 123 when the mass spectrometry analysis module detects the first sample is different from the mass range of the second mass analyzer 123 when the mass spectrometry analysis module detects the second sample.
[0085] In in vitro diagnostics, when performing mass spectrometry analysis, the second mass analyzer is used to analyze daughter ions, which are obtained by breaking down the parent ion. Daughter ions typically have a lower mass-to-charge ratio than the parent ion. Therefore, the operating frequency of the radio frequency voltage can be dynamically adjusted to achieve optimal performance for the first and / or second mass analyzers. This means specifically optimizing the operating frequencies of the first and second mass analyzers to improve the system response.
[0086] For example, as shown in Table 1, when analyzing substances with low mass-to-charge ratios such as vitamins, better system response performance can be obtained by increasing the operating frequencies of the radio frequency (RF) voltages of the first and second mass analyzers. When analyzing high molecular weight drugs such as tacrolimus, the upper limit of the analytical mass range can be extended by decreasing the operating frequencies of the RF voltages of the first and second mass analyzers. Furthermore, the operating frequencies of the RF voltages of the first and second mass analyzers can be specifically selected based on the mass-to-charge ratio of the parent ion and the daughter ion.
[0087] Table 1. Ion mass-to-charge ratio for different detection items
[0088] In some implementations, the first sample and the second sample are different samples, such as test samples from different subjects. That is, the mass spectrometry analysis system 100 is used to perform mass spectrometry detection and analysis on the first sample and the second sample sequentially. For example, the first sample may be a test sample from a first subject, while the second sample may be a test sample from a second subject different from the first subject. At this time, an exemplary detection process of the mass spectrometry analysis system 100 is as follows: the sample information acquisition module 110 acquires the first detection item information of the first sample; the controller 130 acquires the first detection item information of the first sample from the sample information acquisition module 110 and determines a first operating frequency and / or a second operating frequency based on the first detection item information; then the controller 130 controls the mass spectrometry analysis module to perform mass spectrometry detection on the first sample, wherein the first mass analyzer operates at the first operating frequency determined based on the first detection item information, and / or the second mass analyzer operates at the second operating frequency determined based on the first detection item information; after the mass spectrometry analysis module finishes the mass spectrometry detection of the first sample, the sample information acquisition module 110 acquires the second detection item information of the second sample; the controller 130 acquires the second detection item information of the second sample from the sample information acquisition module 110 and determines a first operating frequency and / or a second operating frequency based on the second detection item information; then the controller 130 controls the mass spectrometry analysis module to perform mass spectrometry detection on the second sample, wherein the first mass analyzer operates at the first operating frequency determined based on the second detection item information, and / or the second mass analyzer operates at the second operating frequency determined based on the second detection item information. Here, when the first detection item information is different from the second detection item information, the first working frequency determined based on the first detection item information is different from the first working frequency determined based on the second detection item information, and / or the second working frequency determined based on the first detection item information is different from the second working frequency determined based on the second detection item information.
[0089] In some other implementations, the first and second samples come from the same sample, such as a test sample from the same subject. That is, in this case, the mass spectrometry analysis system 100 is used to perform mass spectrometry detection and analysis on the first and second samples from the same sample sequentially. At this time, an exemplary detection process of the mass spectrometry analysis system 100 is as follows: The sample information acquisition module 110 acquires the detection item information of the same sample, which includes first detection item information and second detection item information that are different from each other (that is, mass spectrometry detection for two different detection items is required for the same sample). The controller 130 acquires the detection item information from the sample information acquisition module 110. The controller 130 determines a first operating frequency and / or a second operating frequency based on the first detection item information and determines a first operating frequency and / or a second operating frequency based on the second detection item information. Then, the controller 130 controls the mass spectrometry analysis module to perform mass spectrometry detection on the first sample, wherein the first mass analyzer operates at the first operating frequency determined based on the first detection item information, and / or the second mass analyzer operates at the second operating frequency determined based on the first detection item information. After the mass spectrometry analysis module finishes the mass spectrometry detection of the first sample, the controller 130 controls the mass spectrometry analysis module to perform mass spectrometry detection on the second sample, wherein the first mass analyzer operates at the first operating frequency determined based on the second detection item information, and / or the second mass analyzer operates at the second operating frequency determined based on the second detection item information. Here, the first working frequency determined based on the first detection item information is different from the first working frequency determined based on the second detection item information, and / or the second working frequency determined based on the first detection item information is different from the second working frequency determined based on the second detection item information.
[0090] In some embodiments, the power supply unit 127 includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate a first DC voltage and a first radio frequency power signal, and the second power supply component is configured to generate a second DC voltage and a second radio frequency power signal.
[0091] In some embodiments, as shown in FIG6, the power supply unit 127 includes a tuning component for tuning an RF power signal, for example, generating a target voltage on a quality analyzer via LC resonance. The power supply unit 127 includes a first tuning component 101 and a second tuning component 102. The first tuning component 101 is configured to tune a first RF power signal to generate an RF voltage having a first operating frequency, while the second tuning component 102 is configured to tune a second RF power signal to generate an RF voltage having a second operating frequency. For example, the first power supply component of the power supply unit 127 includes the first tuning component 101, and the second power supply component of the power supply unit 127 includes the second tuning component 102.
[0092] Here, adjusting the first operating frequency is achieved by adjusting the capacitor and / or inductor of the first tuning component, and / or adjusting the second operating frequency is achieved by adjusting the capacitor and / or inductor of the second tuning component.
[0093] In other words, the controller 130 can be configured to adjust a first operating frequency by adjusting the capacitance or inductance of the first tuning component 102, or by simultaneously adjusting the capacitance and inductance of the first tuning component. Alternatively or additionally, the controller 130 can be configured to adjust a second operating frequency by adjusting the capacitance or inductance of the second tuning component 102, or by simultaneously adjusting the capacitance and inductance of the second tuning component.
[0094] Furthermore, the controller 130 may also be configured to operate the first and second quality analyzers at different operating frequencies by adjusting the capacitance and / or inductance of the first and / or second tuning components.
[0095] In some embodiments, the operating frequency of the radio frequency voltage can be adjusted within the range of 500 kHz to 2 MHz; that is, the power supply unit 127 can be configured to generate a radio frequency voltage with an operating frequency in the range of 500 kHz to 2 MHz. In other words, the first operating frequency and / or the second operating frequency are in the range of 500 kHz to 2 MHz.
[0096] In some embodiments, the operating frequencies of the first and second quality analyzers can be selected independently. That is, the power supply unit 127 can be configured such that its first and second operating frequencies can be adjusted independently of each other. This allows the first and second quality analyzers to operate at different operating frequencies; for example, the second quality analyzer typically operates at a higher frequency than the first quality analyzer, thereby improving system sensitivity.
[0097] In some embodiments, the controller 130 includes a memory and a processor, wherein the memory stores the relationship between detection item information and a first operating frequency and / or the relationship between detection item information and a second operating frequency. Accordingly, adjusting the first operating frequency may include the processor adjusting the first operating frequency based on the relationship between the detection item information and the first operating frequency stored in the memory. Alternatively or additionally, adjusting the second operating frequency may include the processor adjusting the second operating frequency based on the relationship between the detection item information and the second operating frequency stored in the memory. Thus, the controller 130 is able to simply retrieve the relationship between the detection item information and the first and / or second operating frequencies from the memory and automatically determine the operating frequency matching the retrieved detection item information based on this relationship.
[0098] Furthermore, the relationship between the detection item information and the first operating frequency and / or the relationship between the detection item information and the second operating frequency is stored in the memory in the form of a mapping table.
[0099] In some specific examples, controller 130 can be configured to determine, by lookup table method, a first operating frequency of the first quality analyzer corresponding to the first and second test item information, respectively, to determine the corresponding quality range. Alternatively or additionally, controller 130 can be configured to determine, by lookup table method, a second operating frequency of the second quality analyzer corresponding to the first and second test item information, respectively, to determine the corresponding quality range. This allows for simple adjustment of the quality range of the quality analyzer.
[0100] In some embodiments, the mass spectrometry analysis system further includes an operation module (not shown), such as an operation screen, which is configured to edit, delete, or add the relationship between the detection item information stored in the memory and the first operating frequency and / or the relationship between the detection item information and the second operating frequency through the operation interface.
[0101] In other embodiments, the controller 130 may also be configured to determine a corresponding mass range based on a function of the charge-to-mass ratio of the analyte.
[0102] In some embodiments, the mass spectrometry analysis system 100 is a liquid chromatography-mass spectrometry system, that is, the mass spectrometry analysis system 100 further includes a pretreatment module and a liquid chromatography module. The pretreatment module is configured to pretreat the first sample and the second sample respectively, for example, pretreatment based on magnetic beads. The liquid chromatography module is configured to perform chromatographic separation on the pretreated first sample and the second sample respectively. The chromatographically separated first sample and second sample are respectively transferred to the mass spectrometry analysis module.
[0103] Here, the pretreatment module and the liquid chromatography module can be controlled by the controller 130. That is, the controller 130 is also configured to control the pretreatment module to pretreatment the first sample and the second sample, control the liquid chromatography module to perform chromatographic separation of the pretreated first sample and the second sample, and control the transfer of the chromatographically separated first sample and the second sample to the mass spectrometry analysis module.
[0104] This application also provides a method 400 for running a mass spectrometry analysis module. The mass spectrometry analysis module includes a first mass analyzer, a collision cell, and a second mass analyzer. The mass spectrometry analysis module here can be the mass spectrometry analysis module 120 of any of the above embodiments.
[0105] As shown in Figure 7, method 400 includes: step S410, acquiring sample information of the sample, such as detection item information; step S420, determining the mass range of the first mass analyzer and / or the second mass analyzer that matches the sample information based on the sample information; and step S430, causing the first mass analyzer and / or the second mass analyzer to operate within the mass range matching the sample information when controlling the mass spectrometry analysis module to detect the sample. This allows for optimization of system performance for different samples.
[0106] In particular, method 400 is run automatically by the mass spectrometry analysis module, that is, it automatically and dynamically adjusts the mass range of the mass analyzer according to the acquired sample information, so that the system performance matches the sample information. In other words, it achieves automatic and targeted optimization of system performance without the need for user intervention to manually select the mass range corresponding to the sample information. This not only improves the system detection performance, but also reduces the user's burden and avoids errors caused by the user manually selecting the mass range.
[0107] In a specific example, in step S410, the first detection item information of the first sample and the second detection item information of the second sample are obtained. Accordingly, in steps S420 and S430, when the first detection item information is different from the second detection item information, the first mass analyzer 121 is adjusted so that the mass range of the first mass analyzer 121 when the mass spectrometry analysis module 120 detects the first sample is different from the mass range of the first mass analyzer 121 when the mass spectrometry analysis module 120 detects the second sample, and / or, the mass range of the second mass analyzer 123 is adjusted so that the mass range of the second mass analyzer 123 when the mass spectrometry analysis module 120 detects the first sample is different from the mass range of the second mass analyzer 123 when the mass spectrometry analysis module 120 detects the second sample.
[0108] An exemplary detection process of the mass spectrometry analysis module 120 is described here: First detection item information of the first sample is acquired; based on the first detection item information, the mass range of the first mass analyzer 121 and the second mass analyzer 123 matching the first detection item information is determined; then, the mass spectrometry analysis module 120 is controlled to detect the first sample, at which time the first mass analyzer 121 and the second mass analyzer 123 operate within the mass range matching the first detection item information; after the mass spectrometry analysis module 120 completes the detection of the first sample, second detection item information of the second sample is acquired; when the first detection item information differs from the second detection item information, the mass range of the first mass analyzer 121 and the second mass analyzer 123 is adjusted to match the first detection item information; then, the mass spectrometry analysis module 120 is controlled to detect the second sample, at which time the first mass analyzer 121 and the second mass analyzer 123 operate within the mass range matching the second detection item information.
[0109] In some embodiments, the mass spectrometry analysis module 120 further includes a power supply unit 127. When controlling the mass spectrometry analysis module 120 to detect a first sample or a second sample, the power supply unit 127 applies a first DC voltage and a radio frequency voltage with a first operating frequency to the first mass analyzer 121, and applies a second DC voltage and a radio frequency voltage with a second operating frequency to the second mass analyzer 123. Here, the mass range of the first mass analyzer is adjusted by adjusting the first operating frequency, and / or the mass range of the second mass analyzer is adjusted by adjusting the second operating frequency.
[0110] For example, the method may include: acquiring detection item information of the sample; determining a first operating frequency and / or a second operating frequency matching the detection item information based on the sample's detection item information; and, when controlling the mass spectrometry analysis module to detect the sample, causing the first mass analyzer to operate at the first operating frequency and / or causing the second mass analyzer to operate at the second operating frequency. This method is particularly automated by the mass spectrometry analysis module, i.e., automatically and dynamically adjusting the operating frequency of the mass analyzer based on the acquired detection item information, so that the system performance matches the sample's detection item information. This achieves automatic and targeted optimization of system performance without requiring user intervention to manually select the mass analyzer operating frequency corresponding to the detection item information, thereby not only improving system detection performance but also reducing the user's burden and avoiding errors caused by manual selection of the operating frequency by the user.
[0111] In a specific example, the method may include: acquiring first detection item information of a first sample and second detection item information of a second sample; when the first detection item information differs from the second detection item information, adjusting the first operating frequency to adjust the first mass analyzer so that the mass range of the first mass analyzer is different when the mass spectrometry analysis module detects the first sample compared to when the mass spectrometry analysis module detects the second sample; and / or adjusting the second operating frequency to adjust the second mass analyzer so that the mass range of the second mass analyzer is different when the mass spectrometry analysis module detects the first sample compared to when the mass spectrometry analysis module detects the second sample.
[0112] In some embodiments, the power supply unit includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate a first DC voltage and a first radio frequency power signal, and the second power supply component is configured to generate a second DC voltage and a second radio frequency power signal.
[0113] Furthermore, the power supply unit 127 includes a first tuning component 101 and a second tuning component 102. When the mass spectrometry analysis module detects the first sample or the second sample, the first tuning component tunes the first radio frequency power signal to generate a radio frequency voltage with a first operating frequency, and the second tuning component tunes the second radio frequency power signal to generate a radio frequency voltage with a second operating frequency. In this method, adjusting the first operating frequency is achieved by adjusting the capacitance and / or inductance of the first tuning component, and / or adjusting the second operating frequency is achieved by adjusting the capacitance and / or inductance of the second tuning component.
[0114] In some embodiments, the first operating frequency and / or the first operating frequency is in the range of 500 kHz to 2 MHz.
[0115] In some embodiments, the first operating frequency and the first operating frequency can be adjusted independently of each other.
[0116] In some embodiments, adjusting the first operating frequency includes adjusting the first operating frequency based on a pre-stored relationship between detection item information and the first operating frequency. Alternatively or additionally, adjusting the second operating frequency includes adjusting the second operating frequency based on a pre-stored relationship between detection item information and the second operating frequency. Thus, it is possible to easily and automatically determine an operating frequency matching the acquired detection item information based on the relationship between the detection item information and the first and / or second operating frequencies.
[0117] In some embodiments, the relationship between detection item information and a first operating frequency and / or the relationship between detection item information and a second operating frequency are pre-stored in the form of a mapping table.
[0118] For example, the operating frequencies of the first and / or second quality analyzers corresponding to the first and second test item information can be determined by looking up tables, thereby determining the corresponding quality ranges.
[0119] In some embodiments, the relationship between pre-stored detection item information and the first operating frequency and / or the relationship between detection item information and the second operating frequency can be edited, deleted, or added through the user interface.
[0120] In some embodiments, a scanner is used to obtain the sample information for the detection items of the sample.
[0121] In some embodiments, user input is received via a user interface to obtain detection item information for the sample.
[0122] In some embodiments, the first sample and the second sample are different samples, or the first sample and the second sample come from the same sample.
[0123] All features or combinations of features mentioned above in the specification, drawings, and claims may be used in any combination or individually, provided they are meaningful within the scope of this application and do not contradict each other. The advantages and features described in the mass spectrometry analysis system provided with reference to the embodiments of this application are applicable in a corresponding manner to the method provided in the embodiments of this application for running the mass spectrometry analysis module, and vice versa.
[0124] The above description is merely a preferred embodiment of this application and does not limit the patent scope of this application. All equivalent modifications made based on the inventive concept of this application and the contents of the specification and drawings of this application, or direct / indirect applications in other related technical fields, are included within the patent protection scope of this application.
Claims
1. A mass spectrometry system comprising a sample information acquisition module, a mass spectrometry module, and a controller, wherein, The sample information acquisition module is configured to acquire the detection item information of the sample. The mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage with a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage with a second operating frequency to be applied to the second mass analyzer. The controller is communicatively connected to the sample information acquisition module and the mass spectrometry analysis module and is configured to: acquire first detection item information of the first sample and second detection item information of the second sample from the sample information acquisition module; The controller is further configured to: when the first detection item information is different from the second detection item information, adjust the first mass analyzer by adjusting the first operating frequency, such that the mass range of the first mass analyzer is different when the mass spectrometry analysis module is controlling the detection of the first sample compared with the mass range of the first mass analyzer when the mass spectrometry analysis module is controlling the detection of the second sample; and / or, adjust the second mass analyzer by adjusting the second operating frequency, such that the mass range of the second mass analyzer is different when the mass spectrometry analysis module is controlling the detection of the first sample compared with the mass range of the second mass analyzer when the mass spectrometry analysis module is controlling the detection of the second sample.
2. The mass spectrometry system of claim 1, wherein, The power supply unit includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate the first DC voltage and the first radio frequency power signal, and the second power supply component is configured to generate the second DC voltage and the second radio frequency power signal.
3. The mass spectrometry system of claim 2, wherein, The power supply unit further includes a first tuning component and a second tuning component. The first tuning component is configured to tune the first radio frequency power signal to generate the radio frequency voltage having a first operating frequency, and the second tuning component is configured to tune the second radio frequency power signal to generate the radio frequency voltage having a second operating frequency. as well as The adjustment of the first operating frequency is achieved by adjusting the capacitance and / or inductance of the first tuning component, and / or the adjustment of the second operating frequency is achieved by adjusting the capacitance and / or inductance of the second tuning component.
4. The mass spectrometry system of any one of claims 1 to 3, wherein, The first operating frequency and / or the second operating frequency are in the range of 500kHz to 2MHz.
5. The mass spectrometry system of any one of claims 1 to 4, wherein, The power supply unit is configured such that the first operating frequency and the second operating frequency can be adjusted independently of each other.
6. The mass spectrometry system of any one of claims 1 to 5, wherein, The controller includes a memory and a processor, the memory storing the relationship between detection item information and a first operating frequency and / or the relationship between detection item information and a second operating frequency; as well as The adjustment of the first operating frequency includes: the processor adjusting the first operating frequency according to the relationship between the detection item information stored in the memory and the first operating frequency, and / or the adjustment of the second operating frequency includes: the processor adjusting the second operating frequency according to the relationship between the detection item information stored in the memory and the second operating frequency.
7. The mass spectrometry system of claim 6, wherein, The relationship between the detection item information and the first operating frequency and / or the relationship between the detection item information and the second operating frequency is stored in the memory in the form of a mapping table.
8. The mass spectrometry analysis system according to claim 6 or 7 further includes an operation module, the operation module being configured to edit, delete or add the relationship between the detection item information stored in the memory and the first operating frequency and / or the relationship between the detection item information and the second operating frequency through an operation interface.
9. The mass spectrometry system of any one of claims 1 to 8, wherein, The sample information acquisition module includes a scanner for scanning the markings on the sample container containing the sample to obtain the test item information of the sample.
10. The mass spectrometry system of any one of claims 1 to 8, wherein, The sample information acquisition module includes a user interface for receiving the detection item information of the sample input by the user.
11. The mass spectrometry analysis system according to any one of claims 1 to 10, wherein, The first sample and the second sample are different samples, or The first sample and the second sample come from the same sample.
12. The mass spectrometry analysis system according to any one of claims 1 to 11, further comprising a pretreatment module and a liquid chromatography module, wherein the controller is further configured to control the pretreatment module to pretreatment the first sample and the second sample, control the liquid chromatography module to perform chromatographic separation of the pretreated first sample and the second sample, and control the transfer of the chromatographically separated first sample and second sample to the mass spectrometry analysis module.
13. A mass spectrometry analysis system, including: The sample information acquisition module is configured to acquire the detection item information of the sample; The mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage having a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage having a second operating frequency to be applied to the second mass analyzer. as well as The controller, which is communicatively connected to the sample information acquisition module and the mass spectrometry analysis module, is configured to: Based on the detection item information of the sample, determine the first working frequency and / or the second working frequency that matches the detection item information; as well as When controlling the mass spectrometry analysis module to detect the sample, the first mass analyzer is operated at the first operating frequency and / or the second mass analyzer is operated at the second operating frequency.
14. Method for operating a mass spectrometry module, wherein, The mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage with a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage with a second operating frequency to be applied to the second mass analyzer. The method includes: Obtain the first detection item information for the first sample and the second detection item information for the second sample. When the information of the first detection item is different from the information of the second detection item, the first mass analyzer can be adjusted by adjusting the first operating frequency, so that the mass range of the first mass analyzer when controlling the mass spectrometry analysis module to detect the first sample is different from the mass range of the first mass analyzer when controlling the mass spectrometry analysis module to detect the second sample, and / or, the second mass analyzer can be adjusted by adjusting the second operating frequency, so that the mass range of the second mass analyzer when controlling the mass spectrometry analysis module to detect the first sample is different from the mass range of the second mass analyzer when controlling the mass spectrometry analysis module to detect the second sample.
15. The method of claim 14, wherein, The mass spectrometry analysis module further includes a power supply unit, wherein the power supply unit includes a first power supply component and a second power supply component that are independent of each other. The first power supply component is configured to generate the first DC voltage and the first radio frequency power signal, and the second power supply component is configured to generate the second DC voltage and the second radio frequency power signal.
16. The method of claim 15, wherein, The power supply unit further includes a first tuning component and a second tuning component. When controlling the mass spectrometry analysis module to detect the first sample or the second sample, the first tuning component is used to tune the first radio frequency power signal to generate the radio frequency voltage with the first operating frequency, and the second tuning component is used to tune the second radio frequency power signal to generate the radio frequency voltage with the second operating frequency. as well as In the method, adjusting the first operating frequency is achieved by adjusting the capacitance and / or inductance of the first tuning component, and / or adjusting the second operating frequency is achieved by adjusting the capacitance and / or inductance of the second tuning component.
17. The method of any one of claims 14 to 16, wherein, The first operating frequency and / or the second operating frequency are in the range of 500kHz to 2MHz; and / or The first operating frequency and the second operating frequency can be adjusted independently of each other.
18. The method of any one of claims 14 to 17, wherein, The adjustment of the first operating frequency includes: adjusting the first operating frequency according to the relationship between pre-stored detection item information and the first operating frequency, and / or The adjustment of the second operating frequency includes: adjusting the second operating frequency according to the relationship between pre-stored detection item information and the second operating frequency.
19. The method of claim 18, wherein, The relationship between the detection item information and the first working frequency and / or the relationship between the detection item information and the second working frequency are pre-stored in the form of a mapping table.
20. The method of claim 18 or 19, wherein, The relationship between pre-stored detection item information and the first working frequency and / or the relationship between detection item information and the second working frequency can be edited, deleted, or added through the operation interface.
21. The method of any one of claims 14 to 20, wherein, The sample information for the test items is obtained by using a scanner.
22. The method of any one of claims 14 to 20, wherein, The system receives user input through a user interface to obtain information about the test items for the sample.
23. The method of any one of claims 14 to 22, wherein, The first sample and the second sample are different samples, or The first sample and the second sample come from the same sample.
24. A method for operating a mass spectrometry module, wherein, The mass spectrometry analysis module includes a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit. The power supply unit is configured to generate a first DC voltage and a radio frequency voltage with a first operating frequency to be applied to the first mass analyzer, and a second DC voltage and a radio frequency voltage with a second operating frequency to be applied to the second mass analyzer. The method includes: Obtain information on the test items for the sample; Based on the detection item information of the sample, determine the first operating frequency and / or the second operating frequency that matches the detection item information; and When controlling the mass spectrometry analysis module to detect the sample, the first mass analyzer is operated at the first operating frequency and / or the second mass analyzer is operated at the second operating frequency.