Cleaning station

Abstract

A device (1) for handling a fluid, comprising a base station (100) and a fluid manipulation head with at least a first needle (201) for handling the fluid, and a fluid well holder (400), in particular a well plate-holder. The fluid manipulation head is positionable above the fluid well holder (400). The device (1) further comprises a cleaning station (500), wherein the cleaning station (500) is movable relative to the base station (100) in order to be positionable below the fluid manipulation head.

Description

[0001] Cleaning station

[0002] Technical Field

[0003] The invention relates to a device for handling a fluid, comprising a base station and a fluid manipulation head with at least a first needle for handling the fluid, and a fluid well holder, in particular a well plate-holder, wherein the fluid manipulation head is positionable above the fluid well holder, and wherein the device further comprises a cleaning station. Furthermore, the invention relates to a method for cleaning a needle using such a device.

[0004] Background Art

[0005] In many areas of biotechnology, for example peptide synthesis, ELISA, bead-based assays, cell-based assays and microsphere-based assays or similar, as well as in general chemistry, e.g. chemical analysis, the dosing and the aspirating of small volumes is of great importance.

[0006] Automated aspirating and dispensing units can tremendously improve the throughput in some of the mentioned fields by automatically aspirating or dispensing liquids into reaction vessels, for example into the wells of a microplate. An exemplary device is marketed by Fritz Gyger AG, for example, under the name Certus-Flex.

[0007] A major challenge after using such systems is to clean the needles used to dose or aspirate a liquid. In particular, when aspirating, the aspirating needles inevitably come into contact with the liquid in the well plate and must therefore be cleaned. This step is important, as high demands are generally placed on the cleanliness of the needles when they are reused. It is particularly important to avoid cross-contamination, where impurities can be carried over into the next process. The cleaning process should also remove any clogging and deposits from the needles.

[0008] Therefore, it is known in the art to provide devices for handling a fluid with a cleaning station. However, the known devices for handling a fluid, comprising a cleaning station have

[0009] 29084-EP1 - PR / SG / qub Keller Schneider

[0010] 16 December 2025 Patent- und Markenanwalte the disadvantage, that the known devices are complex design and therefore expensive. They also typically require a relatively large amount of space.

[0011] Summary of the invention

[0012] It is the object of the invention to create a device pertaining to the technical field initially mentioned, which has a particularly simple structure.

[0013] The solution of the invention is specified by the features of claim 1. According to the invention, the cleaning station is movable relative to the base station in order to be positionable below the fluid manipulation head.

[0014] The fact that the cleaning station is designed to be movable relative to the base station means that a particularly compact device for handling a fluid can be provided.

[0015] To clean the needle with the cleaning station, the cleaning station is preferably moved towards the fluid manipulation head. This has the advantage that the fluid manipulation head can be formed with one degree of freedom less (which is taken over by the movable cleaning station). The fact that the cleaning station can be moved away from the fluid manipulation head after the cleaning process has been completed means that the working area around the fluid manipulation head is not or less affected. This increases the flexibility of the work processes around the fluid manipulation head, especially the fluid well holder.

[0016] The device for handling a fluid is preferably intended for handling small quantities of fluid, in particular for ELISA procedures. However, the device can also be provided for other applications in which fluids are dosed or aspirated and a needle used in the process has to be cleaned.

[0017] The term 'base station' refers to that part of the device, which is stationary during use of the device. The base station preferably comprises a support frame for the individual components, in particularthe fluid manipulation head, the fluid well holder and the cleaning station. Furthermore, the base station preferably comprises a housing.

[0018] 29084-EP1 - PR / SG / qub Keller Schneider

[0019] 16 December 2025 Patent- und Markenanwalte The fluid manipulation head comprises a first needle for handling the fluid. The fluid manipulation head is preferably designed in such a way that the needle can be moved at least in the longitudinal direction of the needle.

[0020] This function has the primary purpose of moving the needle towards the fluid well holder for aspirating or dispensing a liquid. When aspirating liquids in particular, it is necessary to immerse the needle in the liquid to be aspirated, which requires a relative movement in the longitudinal direction of the needle between the fluid well holder and the needle. During the cleaning process in the cleaning station, it is usually also necessary to perform such a relative movement, especially if the cleaning station comprises receptacles into which the needles are inserted and cleaned.

[0021] In principle, it is also possible to achieve this relative movement by moving the fluid well holder or the cleaning station in the longitudinal direction of the needle.

[0022] However, the design of the fluid manipulation head in such a way that the needle can be inserted into receptacles of the cleaning station has the advantage that the device only requires one actuator for height adjustment, as the fluid manipulation head can also be moved along the longitudinal direction of the needle to the fluid well holder. This results in a particularly simple design of the device.

[0023] In a method for cleaning a needle of a fluid manipulation head a device for handling a fluid is used that comprises a base station and a fluid manipulation head with at least a first needle for handling the fluid, and a fluid well holder, in particular a well plate-holder. The fluid manipulation head is positionable above the fluid receptacle holder. Therewith, preferably a fluid in a well of the fluid well holder can be manipulated, e.g. aspirated or dosed into the well. The device further comprises a cleaning station, wherein, in the method of cleaning the needle, the cleaning station is moved relative to the base station and the needle is moved along a needle longitudinal direction to the cleaning station. In a further step, the needle is cleaned by the cleaning station.

[0024] Preferably, the cleaning station is movable in a direction perpendicular to the longitudinal direction of the needle. This allows the cleaning station to be introduced efficiently into the

[0025] 29084-EP1 - PR / SG / qub Keller Schneider

[0026] 16 December 2025 Patent- und Markenanwalte movement space of the fluid manipulation head, so that the needle can be cleaned in the cleaning station. Particularly preferably, the cleaning station is designed to be movable exclusively in a direction at right angles to the longitudinal direction of the needle. This results in a particularly simple design of the device.

[0027] The fluid well holder comprises a holder for holding one or more containers such as a well plate or the like. Other possible containers for holding a fluid are known to the skilled person. Preferably, the fluid well holder is also designed to be movable in a direction at right angles to the longitudinal direction of a needle. This allows the fluid well holder and different sections thereof to be efficiently inserted into the movement space of the fluid manipulation head, whereby a fluid can be aspirated or dispensed through the needle in a receptacle of the fluid well holder. Particularly preferably, the fluid well holder is designed to be movable exclusively in a direction at right angles to the longitudinal direction of the needle. This results in a particularly simple design of the device.

[0028] The skilled person is aware that the fluid well holder and the cleaning station can be designed to be movable in other directions. In particular, the fluid well holder and the cleaning station can be designed to be movable in the longitudinal direction of the needle, which means that this direction of movement can be dispensed with in the fluid manipulation head.

[0029] Preferably, the cleaning station is guided along a first direction on the base station via a first rail guide and the fluid well holder is guided along the first direction on the base station via the first rail guide or a second rail guide. During the method, the cleaning station is guided along the first direction on the base station via the first rail guide and the fluid well holder is guided along the first direction on the base station via the first rail guide or a second rail guide.

[0030] The cleaning station and the fluid well holder are particularly preferably guided along the first direction via the same, namely the first rail guide. This results in a simple design of the device. Furthermore, the cleaning station and the fluid well holder can be moved in the same direction, which results in a compact design of the device. On the other hand, two

[0031] 29084-EP1 - PR / SG / qub Keller Schneider

[0032] 16 December 2025 Patent- und Markenanwalte different rail guides can also be provided, whereby the fluid well holder is movably mounted on the second rail guide. This design has the advantage that the two carriages of the cleaning station and the fluid well holder do not interfere or interfere less. In particular, a design can be achieved in which the two carriages can cross each other.

[0033] The first rail guide and, if applicable, the second rail guide can be formed in a manner known to the skilled person. Such a guide can be provided via round bars, for example. Prismatic tracks can also be provided.

[0034] The first rail guide can comprise exactly one rail or more than one rail. In a preferred embodiment, the first rail guide comprises a first, preferably horizontally arranged rail and a second, preferably vertically arranged rail, wherein both the cleaning station and the fluid well holder are guided on the first rail and the second rail. With this design, the two rails are particularly good at absorbing torque transverse to the longitudinal direction of the rail.

[0035] The bearing can be provided via sliding elements or rolling elements. The skilled person is aware of any number of other variants that are suitable for the application in question.

[0036] Preferably, the first rail guide is attached to the side of a housing of the base station. The rail is therefore preferably arranged on a vertical plane. This achieves a compact design.

[0037] In variants, the first rail guide can also be located in a support plane of the device, i.e. a horizontal plane, whereby a more solid design can be achieved.

[0038] The first rail guide can also comprise a combination of several rails that run in parallel, in particular, for example, two or more rails attached to the side of a housing of the base station and two or more rails lying in the horizontal plane.

[0039] If the cleaning station and the fluid well holder are guided on separate rails, one rail is preferably aligned horizontally and the other vertically as described above. It is particularly preferable for the cleaning station to be guided on a horizontally arranged rail guide. Preferably, the fluid well holder is guided on the first rail guide too. However, the skilled person is aware that the cleaning station and the fluid well holder can also be guided on separate rail guides.

[0040] 29084-EP1 - PR / SG / qub Keller Schneider

[0041] 16 December 2025 Patent- und Markenanwalte Instead of the rail guide, a robot or the like can also be provided. Other alternatives are known to the skilled person.

[0042] Preferably, the device comprises a drive for moving the fluid well holder along the first rail guide and the device comprises coupling elements for coupling the cleaning station to the fluid well holder, wherewith the cleaning station can be moved automatically through the fluid well holder. Preferably, the cleaning station is automatically movable exclusively by the fluid well holder. The coupling elements are preferably designed as reversible coupling elements. This means that the cleaning station and the fluid well holder can be connected to and disconnected from each other as required using the coupling elements.

[0043] In addition, the device preferably includes at least one sensor for detecting the coupled configuration of the cleaning station and the fluid well holder and / or the position of the cleaning station in order to ensure that the cleaning station is correctly positioned in the cleaning position.

[0044] During the method, the fluid well holder is moved by the drive along the first rail guide and the cleaning station is connected by the coupling elements, in particular by magnetic coupling elements, to the fluid well holder. The cleaning station is then moved automatically by the fluid well holder, in particular exclusively moved automatically by the fluid well holder. Preferably, the cleaning station is positioned by the fluid well holder or the drive of the fluid well holder in such a way that the needle of the fluid manipulation head can be cleaned by the cleaning station. In order to guide the needle into the cleaning station, a needle unit of the fluid manipulation head or the fluid manipulation head itself is preferably movable in one direction of the needle longitudinal direction. In variants, the cleaning station can also be designed to be raised and lowered in the longitudinal direction of the needle.

[0045] Preferably, the cleaning station is moved to a parking position after the needle has been cleaned. This is preferably done by the drive of the fluid well holder.

[0046] In order to decouple the cleaning station from the fluid well holder, preferably in the parking position of the cleaning station, the cleaning station is locked by locking elements relative to the base station and the fluid well holder is moved away from the cleaning station. This

[0047] 29084-EP1 - PR / SG / qub Keller Schneider

[0048] 16 December 2025 Patent- und Markenanwalte allows the coupling elements to be released and the fluid well holder to be separated from the cleaning station.

[0049] The drive of the fluid well holder can be arranged in the base station or in the fluid well holder itself. Suitable drive systems for driving the fluid well holder are well known to those skilled in the art; these can be based on an electric motor, for example, and can include a belt drive, a rack and pinion drive, spindle drive, etc.

[0050] Preferably, the cleaning station does not have its own drive. The device is preferably designed in such a way that in automatic operation of the device, the cleaning station can be moved along the rail exclusively by the drive of the fluid well holder, in particular by the fluid well holder. This means that automatic movement of the cleaning station is preferably not possible without operating the drive of the fluid well holder.

[0051] This means that the cleaning station is preferably drive-free and therefore not directly connected to a drive, but can only be driven indirectly via the drive of the fluid well holder.

[0052] In other words, there is preferably exactly one drive for driving the cleaning station and the fluid well holder. This means that either only the fluid well holder can be moved with the one (single) drive or both the fluid well holder and the cleaning station can be moved.

[0053] This results in a particularly simple design of the device, as in principle there is no need for a separate drive for the cleaning station. The coupling elements can be used to couple the fluid well holderto the cleaning station, which means that the cleaning station can be moved together with the fluid well holder. The fluid well holder thus preferably serves as a drive for the cleaning station. However, in an alternative embodiment, the drive could be provided for the cleaning station and the fluid well holder would be moved via the cleaning station. In addition to design aspects, the frequency of use must also be taken into account for the arrangement of the drive on the fluid well holder relative to the cleaning station, which means that the drive is preferably coupled to the movable element that is moved more frequently during operation.

[0054] 29084-EP1 - PR / SG / qub Keller Schneider

[0055] 16 December 2025 Patent- und Markenanwalte Furthermore, the cleaning station and the fluid well holder can also have a common drive with which both can be driven directly. For example, a belt drive can be provided for this purpose, into which either the cleaning station or the fluid well holder can mechanically engage or disengage. Other variants are known to the skilled person.

[0056] In a further variation, the fluid well holder and the cleaning station can also be permanently connected to each other, whereby the cleaning station is always moved together with the fluid well holder.

[0057] Preferably, the coupling elements are force-fit coupling elements. This ensures that the coupling elements can be released particularly easily. The coupling elements are preferably released as soon as a limiting tensile force between the fluid well holder and the cleaning station is exceeded. Many such coupling elements are known to the skilled person, and their holding force can be defined accordingly. For example, a friction-fit plug-in connection, a hook connection that loosens under the corresponding tensile force, etc. can be provided.

[0058] Preferably, the coupling elements comprising magnetic coupling elements. This provides particularly simple coupling elements that are characterized by their reliable function. A particular advantage is that no moving parts need to be provided for these coupling elements, which means that the device as a whole can be designed to be cost-effective and robust. In variants, the coupling elements can also be realized in other ways, for example by a positive connection or frictional connection, in particular a plug-in connection, clamp connection, etc. Many possibilities are known to the skilled person.

[0059] The magnetic coupling elements preferably comprise a magnet on the cleaning station and / or on the fluid well holder. In principle, it is sufficient if a magnet is attached either to the cleaning station or to the fluid well holder, whereby a ferromagnetic element or another magnet can be provided as a counterpart to the magnetic coupling element. The ferromagnetic element can preferably be an element already provided at the cleaning station and / or on the fluid well holder, for example a frame element, a screw or the like. This can further simplify the construction of the device.

[0060] 29084-EP1 - PR / SG / qub Keller Schneider

[0061] 16 December 2025 Patent- und Markenanwalte In this case, the cleaning station is preferably guided laterally by a linear guide. This allows the linear guide to be arranged on the housing of the base station. This results in a particularly compact design. In some variants, the linear guide can also be arranged below the cleaning station.

[0062] When sealing the needle with a face seal, it is particularly important that the support for the cleaning station is robust and does not yield in any way under pressure, i.e., it does not yield plastically or elastically. This ensures optimal sealing when cleaning the needle in the cleaning station. This is particularly challenging in the case of a laterally guided linear guide as described above.

[0063] Therefore, the cleaning station is preferably guided on the linear guide in such a way that the cleaning station remains stable even when the needle of the fluid manipulation head is inserted into the needle receptacles of the cleaning station so that the needle receptacles are tightly sealed to the outside. In particular, it is important to prevent the cleaning station from lowering or swiveling around an axis parallel to a guiding direction under the pressure of the fluid manipulation head. In particular, swiveling could mean that the correct alignment of the fluid manipulation head with the cleaning station can no longer be guaranteed, so that receptacles that are further away from the linear guide are at a greater distance from the fluid manipulation head than receptacles that are closer to the linear guide. This could impair the sealing effect during the cleaning process for receptacles that are further away from the linear guide.

[0064] To achieve this, the first rail guide is preferably a dual-support linear guide, in particular an orthogonal linear guide, more preferably a linear ball bearing, in particular a linear recirculating ball bearing. This allows the cleaning station to be supported via a lateral linear guide in such a way that pivoting around a guiding direction can be reduced or prevented. This enables a particularly good sealing effect to be achieved on the receptacles during the cleaning process, because the prevention of the swiveling of the cleaning station ensures that the fluid manipulation head remains correctly aligned with the cleaning station and the sealing effect is not impaired. Other guides may also be provided in variants, in particular, for example, a spindle guide, a dovetail guide, etc.

[0065] 29084-EP1 - PR / SG / qub Keller Schneider

[0066] 16 December 2025 Patent- und Markenanwalte The horizontal guide structure is preferably designed as a hanging guide structure. The horizontal guide structure is particularly preferably designed as a linear ball bearing, in particular a linear recirculating ball bearing. The hanging linear recirculating ball bearing arrangement ensures reliable load transfer and maintains accurate positional alignment even under dynamic conditions. This configuration offers high resistance to lateral forces and minimizes play. Furthermore, the suspended mounting reduces the need for additional support structures, contributing to a compact overall design and facilitating smooth, low- friction movement along the rail.

[0067] This enables secure engagement while ensuring precise linear guidance. Other upper guide structures are also possible in variants.

[0068] Preferably, the vertical-support linear guide is designed as a guide structure which is arranged laterally on the base station. It is particularly preferred that the vertical-support linear guide is also designed as a linear ball bearing, in particular a linear recirculating ball bearing, with the above advantages. However, alternatives to this are known to those skilled in the art (in particular, for example, a roller guide, dovetail guide or the like).

[0069] Preferably, the linear recirculating ball bearing is arranged inside the housing of the base station, whereby the linear recirculating ball bearing is subject to a tensile load (similar to the suspended upper guide structure).

[0070] This overall configuration of the linear guide provides enhanced stability and precise motion control, reducing vibrations and minimizing lateral displacement during operation. The dual-support design allows for higher load capacity and thus greater pressure load capacity during the cleaning process due to the fluid manipulation head. Further, an improved durability compared to single-support guides, ensuring reliable performance even under demanding conditions is achieved. Additionally, the top-guided feature helps maintaining accurate alignment, while the bottom support ensures a robust foundation, resulting in smoother and more consistent linear movement.

[0071] In order to further improve the stability of the cleaning station during the rinsing process, additional support for the cleaning station is preferably provided. This can be provided, for

[0072] 29084-EP1 - PR / SG / qub Keller Schneider

[0073] 16 December 2025 Patent- und Markenanwalte example, by a drain tray. In order to be able to adjust the support precisely, the drain tray can include an adjustment screw, which can be used to adjust the height of the support surface. This further improves the robustness of the cleaning station during the cleaning process. The support surface can be designed as a point, a line, or a surface. Several support surfaces can also be provided.

[0074] Alternatively, other linear guide configurations can be employed depending on the application requirements. Single-support guides, such as bottom-supported or top-guided only designs, may offer simpler installation and lower manufacturing costs.

[0075] Since a side-guided linear guide is preferably used, there is always a risk that the cleaning station may pivot around an axis parallel to the linear guide axis. With this type of linear guide, this pivoting can be minimized so that the precision of the cleaning station's alignment can be largely maintained during use.

[0076] Nevertheless, intensive use over time can cause pivoting, which means that the precision of the alignment can no longer be fully guaranteed. Furthermore, due to manufacturing tolerances, there may already be a slight deviation from the alignment of the cleaning station during assembly. Both effects can be minimized by ensuring a particularly stable construction and / or by pre-swiveling the cleaning station against gravity (preload) so that the expected swiveling can already be compensated for.

[0077] However, in order to get the problem under control permanently, it is preferable to make the alignment of the cleaning station adjustable relative to the rail of the linear guide. In some variants, adjustability is not necessary.

[0078] Preferably, the cleaning station comprises a cleaning device, wherein the cleaning device is adjustable about an axis parallel to a longitudinal axis of the needle, i.e. in the z-direction and / or about an axis parallel to a moving direction of the cleaning station, i.e. in the x- direction.

[0079] This allows the orientation of the cleaning station and the cleaning device to be checked and corrected if necessary during installation of the device and also during maintenance

[0080] 29084-EP1 - PR / SG / qub Keller Schneider

[0081] 16 December 2025 Patent- und Markenanwalte intervals. If the cleaning station is no longer sufficiently precisely aligned due to intensive use, the alignment can be corrected using the two adjustable axes. This ensures that a sufficient sealing effect is maintained when cleaning the needle in the needle receptacle of the cleaning station (see above).

[0082] Alternatively or additionally, the fluid manipulation head can also be designed to be adjustable. In some variants, adjustability can be dispensed with entirely.

[0083] Preferably the cleaning station comprises a support plate for transporting the cleaning device relative to the base station, wherein the cleaning device is adjustable relative to the support plate about an axis parallel to a moving direction of the cleaning station, i.e. in the x-direction.

[0084] Preferably the cleaning station comprises a support plate for transporting the cleaning device relative to the base station. The provision of a support plate enables a modular design. This means that the device can be equipped with different cleaning devices (as well as fluid manipulation heads), for example. It also simplifies maintenance, especially if the cleaning device can be detachably attached to the support plate.

[0085] Another advantage is that the cleaning device can be aligned relative to the support plate. This makes alignment particularly easy. Alternatively, the cleaning station as a whole can be adjusted relative to the rail guide.

[0086] It is particularly preferred that the cleaning device is adjustable relative to the support plate about an axis parallel to a moving direction of the cleaning station, i.e. in the x-direction. This allows the orientation of the cleaning device to be adjusted, which is particularly important for ensuring that the needle receptacles are tightly sealed during the cleaning process.

[0087] Preferably, the cleaning station comprises a shaft between the cleaning device and the support plate, wherein the shaft is aligned in the x-direction and wherein the cleaning device can be pivoted via the shaft. Furthermore, the cleaning station preferably comprises an adjusting screw, which is used to achieve an adjustable stop for the cleaning device in a

[0088] 29084-EP1 - PR / SG / qub Keller Schneider

[0089] 16 December 2025 Patent- und Markenanwalte swivel position relative to the support plate. On the one hand, this enables particularly precise alignment, namely by adjusting the adjusting screw, and on the other hand, it also achieves a particularly simple design. Preferably, after adjustment with the adjusting screw, the cleaning device is fixed to the support plate by means of a fixing screw. Overall, this allows for particularly precise adjustment of the cleaning device's angle to the X-axis.

[0090] In variants, adjustability can also be achieved in other ways, e.g., by means of a laterally acting clamping device or the like. Furthermore, adjustment can also be made between the support plate and the linear guide. Ultimately, it can also be dispensed with entirely.

[0091] Preferably, the cleaning station comprises a support plate for transporting the cleaning device relative to the base station, wherein the support plate is adjustable relative to the linear guide about an axis parallel to a longitudinal axis of the needle.

[0092] The fact that the settings for the respective axes are not made using the same device makes adjustment easier. This means that the axes can be adjusted independently of each other, which is much easier for the operator than adjusting two non-parallel axes at the same time.

[0093] In principle, it is also possible to provide adjustability around the X-axis between the support plate and the linear guide, while adjustability around the Z-axis is provided between the cleaning device and the support plate. Furthermore, it is possible to provide both adjustabilities, i.e., both around the X-axis and around the Y-axis, between the support plate and the linear guide and between the cleaning device and the support plate, respectively.

[0094] For adjustability around the Z-axis, the support plate can be arranged on a carriage of the linear guide so that it can pivot around a pin aligned in the Z-direction. It can be fixed in one orientation using a fixing screw. Other variants are known to those skilled in the art.

[0095] Preferably the device comprises locking elements for locking a position of the cleaning station relative to the base station. This allows the movement along the rail guide to be blocked. This is particularly advantageous if the coupling elements are designed as force-fit coupling elements, especially as magnetic coupling elements. In this case, to release the coupling elements the position of the cleaning station is blocked and the fluid well holder

[0096] 29084-EP1 - PR / SG / qub Keller Schneider

[0097] 16 December 2025 Patent- und Markenanwalte is then removed from the cleaning station with sufficient force. As soon as the holding force of the coupling elements is exceeded, the fluid well holder will be separated from the cleaning station.

[0098] The locking elements can be designed in different ways. For example, a movably mounted latch can be provided on the base station, which in a first position blocks the movement of the cleaning station at least in the direction of the fluid well holder along the rail guide, while in a second position the movement of the cleaning station along the rail guide is free at least in one direction of the fluid well holder. The locking element can be actuated magnetically, for example, so that the cleaning station can be positively locked. The locking elements may also be realized by the fluid manipulation head. This can be positioned in such a way that the movement of the cleaning station can be blocked at least in the direction of the fluid well holder. For this purpose, the fluid manipulation head can be provided with a locking element. Furthermore, an electromagnet can be provided to hold the cleaning station in a locking position. Other variants are known to the skilled person.

[0099] The locking elements can also be dispensed with if necessary. Instead, for example, a spacer element can be provided on the cleaning station or on the fluid well holder, with which one carriage (e.g. the cleaning station) is mechanically pushed away from the other carriage (e.g. the fluid well holder) in order to release the locking elements.

[0100] Preferably, the cleaning station comprises a first and a second needle receptacle having a first and a second opening for receiving the first needle of the fluid manipulation head and the first needle receptacle further comprises a drain opening for the fluid and whereby the fluid manipulation head can be positioned in such a way that the first and a second needle can be positioned in the first and a second needle receptacle. The cleaning station preferably comprises more than two openings for receiving the first needle, the second needle and other needles of the fluid manipulation head (see below).

[0101] The first and the second needle receptacle preferably further comprise a drain opening and / or inlet opening for the fluid.

[0102] 29084-EP1 - PR / SG / qub Keller Schneider

[0103] 16 December 2025 Patent- und Markenanwalte Preferably, the fluid manipulation head comprises at least a first needle, a second needle and a sealing structure for sealing a first and a second needle receptacle of a cleaning station, when the first needle and the second needle are accommodated in the first and the second needle receptacle respectively, wherein the sealing structure comprises an opening,

[0104] - wherein a first longitudinal axis of the first needle and a second longitudinal axis of the second needle extend through the opening of the sealing structure, and wherein an end face of the sealing structure is formed as a sealing surface, which can interact with a counter sealing surface of the cleaning station, in particular in the form of a face seal.

[0105] The needles do not necessarily have to be located within the opening of the sealing structure. The needles can thus be arranged distally, in front of the sealing structure. The needles can, for example, be incorporated in a needle unit in which the sealing structure is set back relative to the longitudinal axis of the needle. Therefore, it is conceivable that the needles could be located outside the sealing structure. However, the longitudinal axis of the needles always protrudes through the opening of the sealing structure.

[0106] While the sealing structure preferably comprises exactly one opening for the two or more needles, it is also conceivable that the sealing structure comprises two or more openings, with at least one of the openings enclosing at least two needles or the longitudinal axis thereof.

[0107] The sealing structure is designed in such a way that at least two needles can be accommodated in the opening of the sealing structure. This allows several needles to be sealed against a cleaning station using a single common sealing structure.

[0108] Compared to known systems, this allows for a particularly simple design, especially since fewer sealing structures are required — ideally, any number of needles can be sealed against a cleaning station with a single sealing structure comprising a single opening. This simplifies the design of the fluid manipulation head. Furthermore, this also simplifies maintenance of the system, especially since, ideally, only a single seal needs to be replaced if necessary.

[0109] 29084-EP1 - PR / SG / qub Keller Schneider

[0110] 16 December 2025 Patent- und Markenanwalte Furthermore, this achieves a particularly good seal. A smaller sealing surface or contact surface can thus be used for the sealing effect between the fluid manipulation head and the cleaning station. Furthermore, the sealing or contact surface can be designed with a simpler geometry, making it easier to achieve uniform pressure across the entire sealing or contact surface.

[0111] Preferably, an end face of the sealing structure is formed as a sealing surface, which can interact with a counter sealing surface of the cleaning station, preferably the form of a face seal. Particularly preferred, the counter surface of the cleaning station interacts exclusively as a face seal.

[0112] A face seal provides highly reliable sealing performance because the load is applied perpendicular to the sealing surface, creating uniform compression across the entire contact area. This design further minimizes leakage paths, especially under pressure or vacuum conditions. Further, a face seal can maintain consistent sealing even when subjected to thermal expansion. Further, the face seal can maintain consistent sealing even at a minor misalignment of components. Face seals also tolerate larger manufacturing tolerances, since the sealing effectiveness depends less on precise diametrical fits than lateral seals do. Their axial compression results in lower friction during assembly and operation, reducing wear and enabling longer service life. In addition, face seals typically can handle higher pressure fluctuations and vibration.

[0113] This achieves a particularly easy-to-achieve sealing effect. This ensures that the fluid manipulation head can be removed from the cleaning station after the cleaning process with essentially no resistance. This is advantageous, for example, compared to a lateral seal, where under certain circumstances static friction must be overcome in order to retract the fluid manipulation head after the cleaning process has been completed. Other types of seals may also be provided in variants. For example, a lateral seal may be provided. Furthermore, a combination of lateral and end seals may be provided. Other variants are known to those skilled in the art.

[0114] 29084-EP1 - PR / SG / qub Keller Schneider

[0115] 16 December 2025 Patent- und Markenanwalte Preferably, the sealing structure comprises a circumferential flange surrounding the opening, wherein an end face of the circumferential flange is formed as the sealing surface. The configuration enables a reliable and uniform sealing effect due to the continuous geometry of the circumferential flange. It also simplifies manufacturing because the sealing surface is integrated directly into the flange end face, reducing the number of separate sealing components. The defined end face provides improved positioning accuracy and repeatability during assembly, enhancing overall sealing performance. The unrestricted shape of the flange allows the sealing structure to be adapted to different installation spaces and functional requirements, providing greater design flexibility without compromising sealing performance.

[0116] Alternatively, the sealing surface may be provided on a separate ring element that is attached to or supported by the sealing structure, rather than being formed on the end face of a circumferential flange.

[0117] Preferably, the sealing structure comprises a rigid material, in particular the circumferential flange is a rigid flange. In order to achieve the sealing effect, a counter sealing structure comprising an elastic material is preferably provided at the cleaning station.

[0118] In variants, the counter sealing structure may also consist of rigid material, while the sealing structure comprises an elastic material. In both cases, a sealing effect is preferably achieved by the contact of a rigid sealing surface with an elastic sealing surface. In further variants, a sealing effect may also be achieved by the contact of two elastic sealing surfaces.

[0119] A cleaning station for cleaning a needle of a fluid manipulation head comprising a first opening for a first needle receptacle and a second opening for a second needle receptacle. The cleaning station further comprises a counter sealing structure for interacting with a sealing structure of a fluid manipulation head, wherein the counter sealing structure comprises an opening, wherein a first longitudinal axis of the first needle receptacle and a second longitudinal axis of the second needle receptacle extend through the opening of the counter sealing structure.

[0120] 29084-EP1 - PR / SG / qub Keller Schneider

[0121] 16 December 2025 Patent- und Markenanwalte While the counter sealing structure preferably comprises one opening for the two or more needle receptacles, it is also conceivable that the counter sealing structure comprises two or more openings, with at least one of the openings enclosing at least two needle receptacles or the longitudinal axis thereof. This allows several needles to be sealed against a cleaning station using a single common sealing structure and counter sealing structure.

[0122] As mentioned above, an end face of the sealing structure is formed as a sealing surface, which can interact with a counter sealing surface of the cleaning station, preferably in the form of a face seal. The advantages are discussed in detail above. The circumferential seal is particularly preferred, designed correspondingly to the circumferential flange of the fluid manipulation head.

[0123] Preferably, the counter sealing structure comprises a circumferential sealing surrounding the needle receptacles. The circumferential seal forms the counter sealing structure of the cleaning device, via which the end seal can be achieved together with the sealing structure of the fluid manipulation head. The circumferential seal forms the counter sealing structure, via which the end seal can be achieved together with the sealing structure. Preferably, the counter sealing structure, in particular the circumferential seal, is designed in such a way that it encloses all needle receptacles. It is particularly preferred that the counter sealing structure, in particular the circumferential seal, has exactly one opening in which all needle receptacles are arranged. Preferably the needle receptacles further comprising a drain opening for draining the fluid.

[0124] Preferably, the counter sealing element essentially has a rectangular shape with an elongated opening. The counter sealing element preferably has the shape of a ring seal. In variants, the counter sealing element may also have the shape of a surface seal, a frame seal, etc.

[0125] The ring seal preferably has a rectangular cross-section. A rectangular ring seal offers several advantages, in particular when used with the sealing structure, preferably with the flange that preferably has a matching rectangular cross-section. The geometry provides a larger and more uniform contact surface, which results in improved load distribution and reduces

[0126] 29084-EP1 - PR / SG / qub Keller Schneider

[0127] 16 December 2025 Patent- und Markenanwalte the risk of local overstressing or extrusion. The defined sealing edges create predictable compression behavior and enhance sealing reliability, particularly in static applications. Because the seal aligns naturally with the rectangular contour of the flange, positioning is more stable and installation tolerances are easier to control. The shape also minimizes material deformation and helps maintain dimensional stability under varying temperatures and pressures. Overall, a rectangular ring seal provides a robust and efficient sealing solution in particular when paired with a precisely matched flange with rectangular cross section.

[0128] However, a wide variety of cross-sections can be used in ring seals. A further common example is the circular cross-section of the O-ring, which provides uniform compression and is suitable for static and dynamic sealing. Rectangular or square cross-sections are used where higher stability, reduced deformation, or defined compression limits are required, often in flange or groove applications. X-rings, also known as quad-rings, feature a four- lobe profile that improves lubrication retention and reduces friction and wear while providing multiple sealing lines. D-shaped profiles offer increased contact area and enhanced stability against rolling, making them useful in unidirectional sealing. V-shaped and U-shaped cross-sections allow for pressure-energized sealing by enabling the lips to expand under internal pressure. Specialized profiles, such as trapezoidal, dovetail, and custom-engineered geometries, are employed when specific load distributions, chemical resistances, or connection geometries require a tailored sealing solution.

[0129] When assembled, all needle receptacles are preferably arranged within the opening of the sealing element. The individual needle receptacles are thus sealed collectively by the sealing element rather than individually. Adjacent needle receptacles are therefore not separated from each other by the sealing element. The cross-section of the sealing element is rectangular in this case, but could also be round, oval, lip-shaped, or otherwise shaped.

[0130] Preferably, the needles of the fluid manipulation head are arranged in a row. In variants, the needles of the fluid manipulation head may also be arranged differently, in particular in several rows. The needle receptacles of the cleaning station are arranged accordingly so that the needles of the fluid manipulation head can be accommodated in the needle receptacles.

[0131] 29084-EP1 - PR / SG / qub Keller Schneider

[0132] 16 December 2025 Patent- und Markenanwalte Preferably, the counter sealing structure has a corresponding elongated opening. If the counter sealing structure is designed as a ring seal, it is preferably designed to correspond to the elongated opening so that bending stresses can be avoided when inserting the seal. In particular, in the case of a ring seal with a rectangular cross-section, the ring seal is preferably prefabricated with a shape corresponding to the opening of the counter sealing structure so that it can be inserted into the cleaning station without stress.

[0133] A conventional ring seal (circular) can also be used in variants. In this case, a receptacle in the cleaning station for the counter sealing structure can be designed in such a way that sharp angles in the sealing structure can be prevented as far as possible.

[0134] The invention further relates to an arrangement comprising a fluid manipulation head and a cleaning station, wherein the sealing structure of the fluid manipulation head and the counter sealing structure of the cleaning station are sealing a first opening of the first needle receptacle and a second opening of the second needle receptacle in a cleaning configuration, when the first needle and the second needle are received in the first needle receptacle and the second needle receptacle respectively.

[0135] In this configuration, the needles can be cleaned in the needle receptacles. Due to the sealing effect between the sealing structure and the counter sealing structure, cleaning solution cannot escape between the fluid manipulation head and the cleaning station during the cleaning process. Due to the special geometry of the sealing structure and the counter sealing structure, fluid exchange between the needle and the needle receptacle is not prevented. However, since only cleaning is performed in this configuration and all needle receptacles and needles must be cleaned equally, this is irrelevant.

[0136] This design generates less dead volume or surfaces where deposits or contaminants could accumulate. This also makes the cleaning process as a whole more effective. Particularly good cleaning results are achieved with a counter sealing structure comprising a ring seal with a rectangular cross-section.

[0137] Preferably, the cleaning station comprises a receptacle for the counter sealing structure. More preferably, the cleaning station comprises a receptacle for a ring seal of the counter

[0138] 29084-EP1 - PR / SG / qub Keller Schneider

[0139] 16 December 2025 Patent- und Markenanwalte sealing structure, in particular preferably for a ring seal with a rectangular cross-section. The receptacle in the cleaning station is preferably designed in such a way that the counter sealing structure, in particular the ring seal, can be accommodated appropriately so that, when the cleaning station is used to clean the needle of the fluid manipulation head, preferably only an inner surface of the counter sealing structure, in particular the ring seal, is exposed to the cleaning solution. This achieves a particularly simple design of the cleaning station. Furthermore, this also results in a surface that is as small as possible and easy to clean, which allows for particularly effective cleaning.

[0140] Preferably, the cleaning station comprises an L-shaped recess surrounding the needle receptacles, on which the counter sealing structure, in particular the ring seal, can be placed. The depth of the L-shaped recess preferably corresponds essentially to the thickness of the sealing structure in the direction of the longitudinal axis of the needle receptacle. This means that the counter sealing structure is preferably essentially flush with a surface of the cleaning station. In variants, the sealing structure may also be lowered or raised relative to the surface of the cleaning station.

[0141] Preferably, the opening of the counter sealing structure is dimensioned such that it closely encloses the needle receptacles. This means that preferably no excessive clearance is provided between the counter sealing structure and the needle receptacles. However, it is clear to those skilled in the art that, during use, the counter sealing structure is typically deformed, which means that a minimal clearance between the counter sealing structure and the needle receptacles may be necessary.

[0142] Despite the small distances, an opening in the counter sealing structure is preferred which is essentially rectangular in shape, i.e., preferably no tapering of the opening is provided in the area between two adjacent needle receptacles. This keeps the structure and surface simple and smooth, enabling more efficient and effective cleaning.

[0143] In variants, a larger clearance between the counter sealing structure and the needle receptacles may also be provided.

[0144] 29084-EP1 - PR / SG / qub Keller Schneider

[0145] 16 December 2025 Patent- und Markenanwalte A method for cleaning at least a first needle and a second needle of a fluid manipulation head is carried out by using an arrangement comprising a fluid manipulation head and a cleaning station, wherein

[0146] - the fluid manipulation head comprises at least a first needle, a second needle and a sealing structure for sealing a first and a second needle receptacle of a cleaning station, when the first needle and the second needle are accommodated in the first and the second needle receptacle respectively, wherein the sealing structure comprises an opening, a first longitudinal axis of the first needle and a second longitudinal axis of the second needle extending through the opening of the sealing structure;

[0147] - the cleaning station comprises an opening for a first and a second needle receptacle, wherein the cleaning station further comprises a counter sealing structure for interacting with a sealing structure of the fluid manipulation head, wherein the counter sealing structure comprises an opening, wherein a first longitudinal axis of the opening for the first needle receptacle and a second longitudinal axis of the second needle receptacle extending through the opening of the counter sealing structure.

[0148] The following steps are performed: a. accommodating the first needle and the second needle in a first and a second needle receptacle of the cleaning station; b. sealing the first and a second needle receptacle of the cleaning station by contacting the counter sealing structure with the sealing structure.

[0149] Preferably, the needles are inserted into the needle receptacles of the cleaning station by lowering the needle unit in the longitudinal direction of the needle. In variants, the cleaning station can also be moved in the longitudinal direction of the needle.

[0150] Preferably, the needles are lowered via a spindle drive. The needle unit can also be lowered and / or raised in other ways, e.g., via belt drive, wedge actuator, etc.

[0151] 29084-EP1 - PR / SG / qub Keller Schneider

[0152] 16 December 2025 Patent- und Markenanwalte The sealing effect is achieved by contacting the sealing structure of the fluid manipulation head or needle unit with the counter sealing structure of the cleaning station.

[0153] The cleaning process preferably comprises a cleaning phase and a rinsing phase. Preferably, at least one cleaning agent is used in the cleaning phase, which is rinsed out in the rinsing phase. Cleaning agents and rinsing agents for corresponding cleaning processes are known to those skilled in the art. Preferably, the cleaning agents and / or rinsing agents are pumped directly into the needle receptacles via the needles and discharged via the drain opening.

[0154] A drying phase may be provided after the rinsing phase. The drying phase may, for example, comprise flushing with a gas, preferably with compressed air or nitrogen or the like. Furthermore, the cleaning station and / or the fluid manipulation head may also be heated during the drying phase. Finally, the needle and the cleaning station may also be dried with heated gas.

[0155] Once cleaning is complete, the needles are removed from the needle receptacle of the cleaning station. The needles are now clean and ready for their next use.

[0156] Preferably, the first needle comprises an area with an enlarged cross-section in a proximal area of the needle in order to seal the opening of the first needle receptacle of the cleaning station.

[0157] The area with the enlarged cross-section can be formed in any way. For example, the needle can include a widening in the proximal area. The needle can also include a separate element that defines the area with an enlarged cross-section, for example a circumferential sealing element, in particular a rubber seal, a plug or the like.

[0158] The region with the enlarged cross-section is preferably connected directly to the needle. In variants, the region with the enlarged cross-section can also be connected indirectly to the needle, for example via a needle holder or the like.

[0159] Preferably, the area with an enlarged cross-section comprises a plug, wherein the needle extends out of the plug, wherein the plug having a greater diameter than the first needle in

[0160] 29084-EP1 - PR / SG / qub Keller Schneider

[0161] 16 December 2025 Patent- und Markenanwalte order to seal the opening of the first needle receptacle of the cleaning station in a cleaning configuration. In variants, the plug can also be dispensed with.

[0162] Preferably, the plug has a lateral outer surface, the lateral outer surface sealing the opening of the first needle receptacle in the cleaning configuration.

[0163] Preferably, the opening comprises a sealing element, in particular an O-ring, wherein the lateral outer surface of the plug is in contact with the sealing element in the cleaning configuration. Therewith, the first needle is preferably introduced into the first needle receptacle in such a way that the lateral outer surface of the plug is in contact with the sealing element, in order to seal the opening of the at last one needle receptacle in the cleaning configuration.

[0164] This achieves a particularly tight seal of the receptacle. This also largely prevents the sealing element, in particular the O-ring, from becoming contaminated during the cleaning process. This is achieved by the O-ring interacting laterally with the plug, meaning that the O-ring is hardly or not at all exposed to the cleaning liquid. An X-ring can also be provided instead of an O-ring. An axial seal can also be provided instead of the radial seal. In particular, if an axial seal is provided, a quad ring can also be provided.

[0165] In the process, the sealing elements, in particular the O-rings, are preferably wetted. This reduces the resistance for the plug, which simplifies the insertion and removal of the plug into the sealing element.

[0166] The lateral outer surface of the plug may have a cylindrical outer shape. This results in a particularly simple plug design. Furthermore, the plug accommodated in the sealing element achieves a sealing effect that is largely independent of the depth of penetration of the plug in the sealing element or the O-ring.

[0167] Alternatively, the plug may have a conical outer shape in at least a distal region, which tapers in the distal direction. The outer diameter is thus preferably reduced evenly from the maximum outer diameter to the needle. Preferably, the plug has the shape of a truncated cone in this area. This achieves an improved fit of the plug in the opening of the receptacle,

[0168] 29084-EP1 - PR / SG / qub Keller Schneider

[0169] 16 December 2025 Patent- und Markenanwalte which leads to an optimum seal of the opening regardless of temperature differences or the like. Furthermore, an improved sealing effect is achieved with less force. This means that when the plug is inserted into the opening of the receptacle, a good sealing effect can be achieved with less force. In variants, the conical outer shape can also be dispensed with. The plug can also be shaped in other ways. In a further preferred embodiment, the plug has a cylindrical shape, particularly preferably the shape of a right circular cylinder.

[0170] Preferably, the opening is surrounded by a rim, which causes the opening to lie in a trough. The rim can be designed in such a way that all openings are arranged in a common trough. For this purpose, the openings are surrounded by the rim. This ensures that the sealing elements inserted into the openings can be particularly well wetted, since a wetting liquid can be prevented from flowing off by the rim. Furthermore, liquid emerging from the openings can be collected. The rim preferably includes a notch which serves as a spout. This allows any excess liquid to be drained in a controlled manner.

[0171] Preferably, the cleaning station further comprises an ultrasonic bath for cleaning the first needle, wherein the ultrasonic bath is neighboring and preferably affixed to the at least one receptacle of the cleaning station. The ultrasonic bath can be used to pre-clean the needles to make the cleaning process particularly efficient. In some variants, the ultrasonic bath can also be dispensed with.

[0172] Preferably, the fluid manipulation head comprises between 2 and 128 needles, preferably between 6 and 90, in particular between 8 and 64 needles, and the cleaning station comprises the equivalent number of receptacles for receiving the needles in the cleaning configuration. In a particularly preferred embodiment, the fluid manipulation head comprises exactly 8, 16, 32 or 64 needles. In variants, more than 128 needles can also be provided.

[0173] Preferably, the needles are aligned in parallel and in a row, in particular in exactly one row. In variants, the needles can also be aligned in more than one row, for example in two rows of 8 needles each. Preferably, all needles are essentially identical, particularly preferably identical. In the present context, 'essentially identical' means that the needles cannot be

[0174] 29084-EP1 - PR / SG / qub Keller Schneider

[0175] 16 December 2025 Patent- und Markenanwalte distinguished in terms of function, this means that the needles are identical, particularly in terms of their dimensions.

[0176] Other advantageous embodiments and combinations of features come out from the detailed description below and the entirety of the claims.

[0177] Brief description of the drawings

[0178] The drawings used to explain the embodiments show:

[0179] Fig. 1 a schematic isometric projection of a device for handling a fluid, comprising a base station, an aspirating unit, a dispensing unit, a well plate holder and a cleaning station;

[0180] Fig. 2 a schematic isometric view on the guiding mechanism for the plate holder and the cleaning station of the embodiment according to figure 1;

[0181] Fig. 3a the embodiment according to figure 1, wherein the cleaning station is in the parking position and the well plate holder is coupled to the cleaning station via the coupling element;

[0182] Fig. 3b the embodiment according to figure 3a, wherein the cleaning station is positioned under the aspirating unit;

[0183] Fig. 3c the embodiment according to figure 3b, wherein aspirating unit is in the cleaning position;

[0184] Fig. 4 a schematic isometric projection of the cleaning station in the parking position;

[0185] Fig. 5 a schematic cross-section along an x,z plane through a needle receptacle of the cleaning unit;

[0186] Fig. 6 a schematic isometric explosion view of the aspirating unit and the cleaning unit;

[0187] 29084-EP1 - PR / SG / qub Keller Schneider

[0188] 16 December 2025 Patent- und Markenanwalte Fig. 7 a schematic isometric explosion view of the aspirating unit and the cleaning unit with a sealing structure of a first embodiment;

[0189] Fig. 8 a schematic isometric explosion view of the cleaning unit with a carriage of a second embodiment;

[0190] Fig. 9 a schematic isometric explosion view of the cleaning unit with a carriage of a second embodiment; and

[0191] Fig. 10 a schematic isometric explosion view of the drain tray.

[0192] In the figures, the same components are given the same reference symbols.

[0193] Preferred embodiments

[0194] For the description of the device, an x, y, z coordinate system is used where the x,y-plane is oriented horizontally, serving as the supporting surface or base for the device. The x-axis and y-axis lie on this horizontal plane, with the z-axis extending vertically. The x,y-plane thus represents the surface upon which the device is placed or mounted, while the z-axis defines the height or elevation of points relative to this horizontal base.

[0195] Figure 1 is an isometric schematic top view of a device 1 for handling a fluid, in particular for dispensing and aspirating a fluid, comprising a base station 100 with a housing 101, an aspirating unit 200 for aspirating a liquid, a dispensing unit 300 for dispensing a liquid, a well plate holder 400 or more generally a fluid well holder for holding a well plate 401, in particular a microplate and a cleaning station 500.

[0196] The dispensing unit 300 is a device to automatically dispense selected liquids into individual wells of the well plate 401, in particular a microplate. The dispensing unit 300 is preferably a CERTUS FLEX dispensing unit that is commercially available from Fritz Gyger AG.

[0197] The dispensing unit 300 is a device to automatically dispense selected liquids into individual wells of a well plate 401, in particular a microplate. The dispensing unit 300 further comprises a dispensing head with several valves that allow to dispense small dosages of

[0198] 29084-EP1 - PR / SG / qub Keller Schneider

[0199] 16 December 2025 Patent- und Markenanwalte liquids. The dispensing head has several channels that allow to dispense more than one liquid during the same workflow, i.e. without a manipulation of the dispensing unit 300. The dispensing head can move along a horizontal y-axis. This allows the dispensing head to position any of its several valves above any one of the wells in a column of wells. The dispensing head in this embodiment is also able to change its height to adapt to different installations and types of microplates.

[0200] The aspirating unit 200 and the dispensing unit 300 are moved together, i.e. they are designed to be movable together in the y-direction and in the z-direction via a common drive. This enables targeted access to individual wells of the well plate.

[0201] Since the needle of the aspirating unit 200 can interfere with the dispensing unit 300 during dispensing, or must dip into the liquid of the well plate during aspiration, the needle unit of the aspirating unit 200 can be moved in the z-direction relative to the dispensing unit 300. This means that the needle of the aspirating unit 200 can be lowered in the z-direction with respect to the dispensing nozzles of the dispensing unit 300. This prevents a collision of the dispensing nozzles of the dispensing unit 300 with the well plate.

[0202] The device 1 also includes a drain tray 800 below the dispensing unit. This serves to collect and control the drainage of liquids. The drain tray 800 is permanently mounted on the base station 100 and is therefore not movable. The drain tray 800 is positioned in such a way that both the well plate holder 400 and the cleaning station 500 can be moved over the drain tray 800.

[0203] Figure 2 is a schematic isometric view on the guiding mechanism for the plate holder and the cleaning station of the embodiment according to figure 1. The well plate holder400 and the cleaning station 500 are movable along an x-axis relative to a ground plate 102 of the base station. For this purpose, the well plate holder 400 is supported on a first carriage 410 and the cleaning station 500 is supported on a second carriage 510. Both the first carriage 410 and the second carriage 510 feature a bearing section cooperating with a first rail guide 110 as well as with a second rail guide 111. The two rail guides 110, 1 11 extend in the x direction and their main bearing surfaces are perpendicular to each other: The bearing

[0204] 29084-EP1 - PR / SG / qub Keller Schneider

[0205] 16 December 2025 Patent- und Markenanwalte surfaces of the first rail guide 110 extend in a vertical plane, whereas the bearing surfaces of the second rail guide 1 11 extend in a horizontal plane. (It is to be noted that a middle section of the second rail guide 1 11 is not shown in Figure 2 in order not to obstruct the view on the first rail guide 110.)

[0206] A spindle 112 extends through the carriages. It cooperates with an inner bearing arranged in the bearing section of the first carriage 410, whereas it extends through a through hole in the bearing section of the second carriage 510, without interacting with this carriage 510. The spindle 112 may be driven by a drive motor 113 in order to move the plate holder 400 along the x axis.

[0207] The device comprises a control unit with which the drive can be controlled. This allows the well plate holder 400 to be positioned relative to the aspirating unit 200 or the dispensing unit 300 so that different wells of the well plate 401 can be approached.

[0208] The aspirating unit 200 and the dispensing unit 300 can be moved in the y-direction relative to the base station 100. This means that the aspirating unit 200 and the dispensing unit 300 can be moved at right angles to the first rail guide. The aspirating unit 200 and the dispensing unit 300 can also be moved in the z-direction. This allows the aspirating unit 200 and the dispensing unit 300 to be moved from a parking position inside the housing 101 to an active position outside the housing 101 (see fig. 1).

[0209] In the procedure, the well plate holder 400 with the well plate 401 and the aspirating unit 200 or the dispensing unit 300 can be moved in such a way that the well plate 401 is located below the aspirating unit 200 or the dispensing unit 300. The aspirating unit 200 or the dispensing unit 300 can then be moved in the y-direction towards the well plate 401, whereby a liquid can be aspirated from the well plate 401 using the aspirating unit 200 or dispensed into the well plate 401 using the dispensing unit 300.

[0210] When aspirating, the needles of the aspirating unit 200 inevitably come into contact with the liquid in the well plate 401 and must therefore be cleaned. For this purpose, the device includes the cleaning station 500.

[0211] 29084-EP1 - PR / SG / qub Keller Schneider

[0212] 16 December 2025 Patent- und Markenanwalte In order to achieve a compact design of the device, the aspirating unit 200 and the dispensing unit 300 cannot be moved in the x-direction. Therefore, it is now intended that the cleaning station 500 can be moved in the x-direction.

[0213] For this purpose, the cleaning station 500 comprises a carriage 510 that can be moved on the first rail guide 110 of the base station 100.

[0214] To keep the device simple and compact, the cleaning station 500 is placed on the first rail guide 110 without a drive. This means that the cleaning station cannot be moved automatically by itself, but can only be moved via the drive of the well plate holder 400. To do this, the drive of the well plate holder 400 can be coupled to the cleaning station 500 in such a way that the cleaning station 500 can be moved along the x-direction by actuating the drive. In the present embodiment, the well plate holder 400 and the cleaning station 500 are equipped with a coupling means by which the well plate holder 400 can be coupled to the cleaning station 500. The coupling means are in the present case designed as a magnetic coupling. This comprises a magnet on the cleaning station 500 and a magnetic element on the well plate holder 400.

[0215] The procedure is explained below with reference to Figures 1, 2, 3a to 3c.

[0216] Figure 1 shows the device for handling a fluid in a situation, where the cleaning station 500 and the well plate holder 400 are both in a parking position. The parking position of the cleaning station 500 is at the opposite end of the rail guide to the parking position of the well plate holder 400.

[0217] In the procedure for cleaning the needles of the aspiration unit 200, the well plate holder 400 is now moved from its parking position (see fig. 1) along the first rail guide in the x- direction to the cleaning station 500, which is in a parking position (see fig. 1). As soon as the distance between the well plate holder 400 and the cleaning station is sufficiently small, the cleaning station 500 docks onto the well plate holder via the magnetic coupling.

[0218] 29084-EP1 - PR / SG / qub Keller Schneider

[0219] 16 December 2025 Patent- und Markenanwalte This situation is shown in Figure 3a, where the cleaning station 500 is in the parking position and the well plate holder 400 is coupled to the cleaning station via the coupling element, i.e. the magnetic element.

[0220] The well plate holder 400 then moves in the opposite direction along the first rail guide 110, pulling the cleaning station 500 along the first rail guide 110.

[0221] The cleaning station 500 is then positioned by the well plate holder 400 under the aspirating unit 200. The aspirating unit 200 is still in the raised position. This situation is shown in figure 3b.

[0222] To carry out the cleaning process, the aspiration unit 200 is now moved downwards in the z-direction so that the needles are positioned in the cleaning station, where the needles are cleaned, which is the active position. This situation is shown in figure 3c.

[0223] After the cleaning process, the aspirating unit 200 is raised again in the z-direction to reach the situation shown in figure 3b, and, if necessary, transferred to its parking position (in the y-direction into the housing 101).

[0224] The cleaning station 500 is then pushed back to its parking position by the well plate holder 400 as shown in figure 3a.

[0225] In this position, the cleaning station 500 is still coupled to the well plate holder 400 via the magnetic coupling. To release this coupling, the device includes a locking element with which the cleaning station can be fixed relative to the base station in the parking position. The locking element includes a latch that arrests the carriage 510 in one direction towards the well plate holder 400.

[0226] After the cleaning station 500 has reached the parking position, the cleaning station 500 is locked in the parking position by means of the locking element, and the well plate holder 400 is moved in the opposite direction, away from the locking element causing the magnetic coupling to disengage, leaving the cleaning station 500 in the parking position while the well plate holder 400 moves away from the cleaning station 500 to the parking position of the well plate holder 400 according to figure 1.

[0227] 29084-EP1 - PR / SG / qub Keller Schneider

[0228] 16 December 2025 Patent- und Markenanwalte Figure 4 shows a schematic isometric projection of the cleaning station 500 in the parking position.

[0229] The cleaning station 500 includes a carrier 510 that is guided on the first rail guide 110 (see above). The carrier 510 is plate shaped and serves as a supporting surface for a cleaning unit 520 and an ultrasonic bath 540.

[0230] The ultrasonic bath 540 is arranged behind the cleaning unit 520 in the x-direction, with the cleaning unit 520 facing the well plate holder 400.

[0231] The ultrasonic bath 540 is intended to pre-clean any stubborn contamination on the needle of the aspirating unit 200 before the cleaning process in the cleaning unit 520.

[0232] The cleaning unit 520 comprises eight needle receptacles 521 in which the needles of the aspirating unit 200 can be received in order to clean them. Furthermore, the cleaning unit

[0233] 520 includes a fluid outlet 528 for the outflow of the cleaning solution. The fluid outlet 528 is connected to a collecting channel within the cleaning unit 520, which in turn is connected to all needle receptacles 521 (see figure 5). Thus, in the process, a cleaning solution can be pumped through the needles into the needle receptacles 521 via the aspirating unit 200, whereby the needles are also cleaned from the outside before the cleaning solution is discharged via the channel from the fluid outlet 528.

[0234] For the magnetic coupling, the well plate holder in this case comprises a first permanent magnet (not shown). The carrier 510 comprises a second permanent magnet, which allows the first permanent magnet to interact magnetically with the second permanent magnet of the carrier 510.

[0235] Figure 5 shows a schematic cross-section along an x,z plane through a needle receptacle

[0236] 521 of the cleaning unit 520.

[0237] The needle unit 520 has the basic shape of an elongated cuboid. The needle receptacle 521 is essentially designed as a bore in the Z-direction. This includes an area with an enlarged cross-section 522 at the entrance of the bore, which is adjoined by a coaxial bore 523 designed to accommodate the needle.

[0238] 29084-EP1 - PR / SG / qub Keller Schneider

[0239] 16 December 2025 Patent- und Markenanwalte Preferably, the needle comprises a proximal plug that serves as a closure for the needle receptacle 521 in the cleaning configuration. The area with an enlarged cross-section 522 is thus provided to receive the needle plug. This prevents uncontrolled leakage of cleaning liquid from the receptacle during the cleaning process. The area with an enlarged crosssection can be accommodated with a sealing element, in particular with an O-ring. Therewith, the sealing of the receptacle during the cleaning configuration can be improved.

[0240] The needle receptacle 521 comprises a drain channel 524, which is connected to a collecting channel 525. The drain channel 524 is arranged in an upper area of the coaxial bore 523 and runs horizontally, i.e. in the x,y plane or in the x direction. This ensures that the needle can also be completely cleaned from the outside.

[0241] The collecting channel 525 is aligned in the y-direction. All inlets of the eight receptacles 521 lead into the same collecting channel 525. This means that the cleaning liquid from all needle receptacles in the process is discharged via the same collecting channel 525.

[0242] The collecting channel 525 runs essentially perpendicular to the coaxial bore 523 and to the drain channel 524. The collecting channel 525 has a larger diameter than the drain channel 524, so that the fluid can be easily discharged through the collecting channel, without causing any back pressure during the cleaning process.

[0243] The drain channels 524 open into the collecting channel 525 in the upper half of the collecting channel 525. This prevents the fluid from flowing back from the collecting channel 525 into the receptacle 521. The collecting channel opens into a fluid outlet 528 through which the fluid can be disposed of (see figure 4).

[0244] Figure 5 also shows an auxiliary channel 526. This is only necessary for manufacturing reasons. It allows the drain channel to be created from the outside by means of a simple drilling operation. The auxiliary channel 526 is then closed with a dowel 529 up to the collecting channel 525 (see figure 6).

[0245] Figure 6 shows a schematic isometric explosion view of the aspirating unit 200 and the cleaning unit 520.

[0246] 29084-EP1 - PR / SG / qub Keller Schneider

[0247] 16 December 2025 Patent- und Markenanwalte The cleaning unit comprises a base body 530 with eight needle receptacles 521 as described above with reference to Figure 5. An O-ring 532 is inserted in each needle receptacle 521 in the area with an enlarged cross-section 522. In order to hold the O-ring 532 in place, a cover element 531 is provided, which has openings corresponding to the openings of the needle receptacle 521, but which have a smaller diameter than the O-rings 532. The cover element 531 is attached to the base body 530 with screws 533.

[0248] The aspirating unit 200 comprises a base body 206 having a receptacle 207 for a needle unit 203.

[0249] The needle unit comprises a tubular aspiration channel 203. The aspiration channel 203 is closed at one end by a plug 205, while at the other end an opening 204 is provided which can be connected to a vacuum source (not shown). In a cleaning process, the opening 204 can also be connected to a cleaning agent source or to compressed air in order to clean the needles.

[0250] Eight needles 201 are arranged at right angles to the longitudinal direction of the aspiration channel 203, which communicate fluidica lly with the interior of the aspiration channel. The eight needles 201 are arranged at regular intervals, in a row and in parallel. Proximally, each needle 201 encloses a plug 202. In the cleaning configuration, each plug 202 seals with an O-ring 532, whereby the needle receptacle 521 is closed. In order to optimize the closing effect, the plug 202 is tapered in the distal direction. In a further variant, the plug 202 can also be circular-cylindrical.

[0251] The receptacle 207 is designed as a longitudinally slotted bore 207, into which the needle unit 203 can be inserted in such a way that the needles 201 project at right angles out of the slot. The needle unit 203 is screwed to the base body 206 with a fixing screw 222. A pinshaped stop 225 at the end of the receptacle 207 in the base body 206 serves as a positioning aid.

[0252] Figure 7 shows a schematic isometric explosion view of the aspirating and dispensing unit

[0253] 200.1 and the cleaning unit 520.1 with a sealing structure of a first embodiment.

[0254] 29084-EP1 - PR / SG / qub Keller Schneider

[0255] 16 December 2025 Patent- und Markenanwalte The cleaning unit comprises a base body 530.1 with 16 needle receptacles 521. All the needle receptacles 521.1 are surrounded by one single sealing element 532.1.

[0256] The sealing element essentially has a rectangular shape with an elongated opening. When assembled, all needle receptacles 521 are arranged within the opening of the sealing element 532.1. The individual needle receptacles 521.1 are thus sealed collectively by the sealing element 532.1 rather than individually. Adjacent needle receptacles 532.1 are therefore not separated from each other by the sealing element 532. The cross-section of the sealing element is rectangular in this case, but could also be round, oval, lip-shaped, or otherwise shaped.

[0257] The base body 530.1 of the cleaning unit 520.1 comprises an L-shaped groove surrounding the 16 needle receptacles 521. The L-shaped groove is designed to accommodate the ring seal 532.1.

[0258] The aspirating unit 200.1 comprises a base body 206.1 having a receptacle 207.1 for a needle assembly 202.1a. The aspirating unit 200.1 comprises a needle assembly 202.1a with a tubular aspiration channel. The aspiration channel is closed at both opposite ends.

[0259] One of the opposite ends has a notch which is designed for alignment with a pin-shaped stop 225.1 of the base body 206.1.

[0260] On its underside, the slotted tube 203.1 comprises a slot into which the needle assembly 202.1a can be inserted. Holes 204.1, 208.1, and 209.1 are formed on a longitudinal side of the slotted tube 203.1 opposite the slot. The bore 204.1 is designed for connection to a dispensing manifold 230.1. The two bores 208.1 and 209.1 are designed for connection to an aspirating manifold 240.1 and 241.1, respectively.

[0261] The dispensing manifold 230.1 is used to supply fluids, in particular cleaning fluids, rinsing fluids, or gases (e.g., air or nitrogen for drying). The aspirating manifolds 240.1 and 241.1 are designed for connection to a vacuum source.

[0262] The needle assembly 202.1a comprises an elongated body with a circumferential groove aligned in the longitudinal direction of the needle. The elongated body comprises 16

[0263] 29084-EP1 - PR / SG / qub Keller Schneider

[0264] 16 December 2025 Patent- und Markenanwalte needles, which are surrounded by the groove aligned in the longitudinal direction of the needle. In the present embodiment, the groove forms the sealing structure, which can interact with the counter seal 532.1.

[0265] The needle assembly 202.1a further comprises, in the proximal direction, a stamp-like region via which the needle assembly 202.1a can be inserted into the slot of the slotted tube 203.1. When the aspirating and dispensing unit 200.1 is assembled, connections 204.1, 208.1, and 209.1 are each in fluid communication with the 16 needles 201.1.

[0266] The aspirating and dispensing unit 200.1 further comprises a base body 206.1 for receiving the needle assembly 202.1a. The base body 206.1 comprises a receptacle 207.1 for receiving the needle assembly 202.1 a. This is designed as a bore with a longitudinal slot, whereby the needle lies in the longitudinal slot when assembled. A pin-shaped stop is provided at the end opposite the opening of the bore, which serves as a stop for the needle unit. During assembly, the needle unit is inserted into the bore until it reaches the stop 225.1 . The needle assembly 202.1a is then screwed tight.

[0267] The base body also comprises several holes transverse to the longitudinal direction of the needle assembly 202.1a. Two holes 223.1a and 224.1a are provided in the x-direction for mounting the base body 206.1. Three holes are provided in the z-direction. Two of these, namely holes 240.1a and 241.1a, are provided for screwing in aspirating manifolds 240.1 and 241.1. The other hole 230.1a is provided for screwing in the dispensing manifold 230.1. A fourth hole 222.1 a in the z-direction is provided for a ball pressure piece 222.1. The ball pressure piece 222.1 snaps into a recess in the slotted tube 203.1 to fix it in place relative to the base body 206.1.

[0268] Figure 8 shows a schematic isometric exploded view of the cleaning unit with a carriage of a second embodiment.

[0269] The cleaning station is guided on the base station via a rail guide, wherein the rail guide is formed as an orthogonal linear recirculating ball bearing. One rail is a suspended rail, and the other is a lateral rail facing the cleaning device 530.1.

[0270] 29084-EP1 - PR / SG / qub Keller Schneider

[0271] 16 December 2025 Patent- und Markenanwalte Accordingly, the slide arrangement 600 on the main body 601 comprises two guides 602 and 603 arranged perpendicular to each other, wherein the guide 603 is configured to guide along the suspended rail 603, and the guide 602 is configured to guide along the lateral rail. The main body 601 comprises a mounting flange 604 lying in the x,y-plane, via which a holding plate 620 can be attached to the slide arrangement 600. The mounting flange 604 is essentially aligned with the suspended rail 603. The holding plate 620 comprises a base plate 621 and a step 622. The attachment and adjustment to the slide arrangement 600 is carried out via the base plate 621 using screws 623, 624 and 626. Bolt 625 is used as a positioning aid during assembly.

[0272] The main body 601 is further connected to a magnet unit 610, comprising a magnet 611. The magnet 611 allows coupling to the fluid well holder, so that the cleaning station can be moved via the fluid well holder.

[0273] The step 622 is formed as a recess in the x,y-plane of the holding plate 620. It is configured to accommodate a staggered parallel rail 630, which comprises a first rail 631 and a second rail 632. The staggered parallel rail 630 is mounted on the step 622 such that it can be pivoted about a Z-axis for adjustment. To this end, the staggered parallel rail 630 is pivotably supported on the second rail 632 via a pin 637 oriented in the Z-direction. To adjust the angle around the Z-axis, an adjusting screw 627 and a compression spring 628 are used, which counteracts the movement of the staggered parallel rail 630 relative to the holding plate around the Z-axis when the adjusting screw 627 is tightened. After adjustment, the staggered parallel rail 630 can be fixed to the holding plate 620 using a first fixing screw 639 and a second fixing screw (not shown).

[0274] The first rail 631 of the staggered parallel rail 630, which is positioned lower in the Z- direction when mounted, serves to accommodate an adjustment support 640, via which the cleaning device 530.1 can be adjusted about the X-axis. For this purpose, the first rail 631 has a notch 638 in the X-direction for receiving a shaft 633. Correspondingly, the adjustment support 640 has a matching notch 642 on its underside for receiving the shaft 633. The shaft 633 has a slightly larger diameter than the sum of the depths of the notches 642 and 638,

[0275] 29084-EP1 - PR / SG / qub Keller Schneider

[0276] 16 December 2025 Patent- und Markenanwalte thereby providing play for movement about the X-axis. The adjustment support 640 can thus be adjusted about the X-axis via the shaft 633.

[0277] The first rail 631 comprises a first bolt 634 and a second bolt (not shown) for lateral guidance of the adjustment support 640. The position can be fixed using disc spring 635 for adjustment and screws 643 at the end of the adjustment support opposite the shaft 633. The preload of the disc spring 635 is defined by the geometry of adjustment support 640 and first rail 631.

[0278] The disc spring 635 generates a torque that pushes the staggered parallel rail 630 and adjustment support 640 apart. The screw 636 located at the disc spring 635 acts as an end stop. This limits the maximum adjustable angle between the staggered parallel rail 630 and adjustment support 640. Screw 643 is the actual adjustment screw, which can be used to adjust the orientation of position 641 around the axis of the shaft 633 relative to the first rail 631. A second disc spring 629 is arranged on the opposite side of the staggered parallel rail 630. The preload of the second disc spring 629 can be adjusted by the corresponding screw 636.

[0279] The adjustment support 640 ultimately serves to receive the cleaning device 530.1. To fix the cleaning device 530.1 on the adjustment support 640, a positioning pin 645 and a magnet 644 on the adjustment support, as well as a corresponding magnet 633.1 on the underside of the cleaning device 530.1, are provided.

[0280] Figure 9 shows a schematic isometric exploded view of the cleaning unit with a carriage of a third embodiment.

[0281] In this embodiment, the slide arrangement 600, the magnet unit 610, and the cleaning device 530.1 are configured identically to the second embodiment of Figure 8.

[0282] The main differences compared to Figure 8 are that the staggered parallel rail 630 is omitted. Accordingly, the holding plate 720 already comprises notches 728 in the step 722. The step 722 is also formed as a recess in the x,y-plane of the holding plate 720. This step 722 serves

[0283] 29084-EP1 - PR / SG / qub Keller Schneider

[0284] 16 December 2025 Patent- und Markenanwalte to accommodate an adjustment support 730, via which the cleaning device 530.1 can be adjusted about the X-axis.

[0285] For this purpose, the step 722 has a notch 728 in the X-direction for receiving a shaft 732. Correspondingly, the adjustment support 730 has a matching notch 737 on its underside for receiving the shaft 732. The shaft 732 also has a slightly larger diameter than the sum of the depths of the notches 737 and 738.

[0286] The step 722 comprises a keyway pin 724 and a corresponding groove for lateral alignment of the adjustment support 730 on the holding plate 720. After the adjustment about the X- axis, the position can be fixed using disc spring 723 and 729 for adjustment and screws 725, 726 analogous to the embodiment shown in Figure 8.

[0287] In contrast to the second embodiment, the adjustment support 730 in the present third embodiment comprises an eccentric shaft 736 with an eccentric wheel aligned parallel to the shaft 732. The eccentric wheel is rotatably mounted in a central recess of the adjustment support 730. By rotating the eccentric shaft 736, the eccentric wheel can be aligned such that it protrudes above the surface of the adjustment support 730, thereby lifting the cleaning station 530.1. This allows simplified removal of the cleaning station.

[0288] The adjustment support 730 serves, analogously to the second embodiment, to receive the cleaning device 530.1. To fix the cleaning device 530.1 on the adjustment support 730, a positioning pin 734 and a magnet 735 on the adjustment support, as well as a corresponding magnet 534.1 on the underside of the cleaning device 530.1, are provided.

[0289] Figure 10 shows a schematic isometric explosion view of the drain tray 800. The drain tray 800 is permanently connected to the base station (not shown). During operation, the drain tray 800 not only serves to drain liquids, but also supports the cleaning station. For this purpose, the drain tray 800 includes a support screw 810, on whose screw head the cleaning station can be supported. The support screw is adjustable so that the height of the screw head can be set precisely. For this purpose, the drain tray 800 comprises a bore with an internal thread 801 into which the support screw 810 can be screwed and adjusted. To keep

[0290] 29084-EP1 - PR / SG / qub Keller Schneider

[0291] 16 December 2025 Patent- und Markenanwalte the play to a minimum during adjustment, a disc spring 811 is provided, which is pressed against the drain tray 800 from below with a nut 812.

[0292] In summary, it is to be noted that the invention provides a particularly compact device for handling a fluid, comprising a cleaning station, which is also particularly simple in design.

[0293] 29084-EP1 - PR / SG / qub Keller Schneider

[0294] 16 December 2025 Patent- und Markenanwalte

Claims

Claims1. A device (1) for handling a fluid, comprising a base station (100) and a fluid manipulation head with at least a first needle (201) for handling the fluid, and a fluid well holder (400), in particular a well plate-holder, wherein the fluid manipulation head is positionable above the fluid well holder (400), and wherein the device (1) further comprises a cleaning station (500), characterized in that the cleaning station (500) is movable relative to the base station (100) in order to be positionable below the fluid manipulation head.

2. The device (1) according to claim 1, characterized in that the cleaning station (500) is guided along a first direction on the base station (100) via a first rail guide (110) and the fluid well holder (400) is guided along the first direction on the base station (100) via the first rail guide (110) or a second rail guide.

3. The device (1) according to claim 2, characterized in that the device (1) comprises a drive for moving the fluid well holder (400) along the first rail guide (110) and the device (1) comprises coupling elements for coupling the cleaning station (500) to the fluid well holder (400), wherewith the cleaning station (500) can be moved automatically by the fluid well holder (400), preferably, the cleaning station (500) is automatically movably exclusively by the fluid well holder (400).

4. The device (1) according to claim 3, characterized in that the coupling elements comprising magnetic coupling elements.

5. The device (1) according to one of claims 2 to 4, characterized in that the first rail guide (110) is a dual-support linear guide, in particular an orthogonal linear guide, more preferably an orthogonal linear ball bearing, in particular a linear recirculating ball bearing.

6. The device (1) according to one of claims 1 to 5, characterized in that the cleaning station comprises a cleaning device, wherein the cleaning device is adjustable about29084-EP1 - PR / SG / qub Keller Schneider16 December 2025 Patent- und Markenanwaltean axis parallel to a longitudinal axis of the needle and / or about an axis parallel to a moving direction of the cleaning station.

7. The device (1) according to claim 6, characterized in that the cleaning station comprises a support plate for transporting the cleaning device relative to the base station (100), wherein the cleaning device is adjustable relative to the support plate about an axis parallel to a moving direction of the cleaning station.

8. The device (1) according to claim 6 or 7, characterized in that the cleaning station comprises a support plate for transporting the cleaning device relative to the base station (100), wherein the support plate is adjustable relative to the linear guide about an axis parallel to a longitudinal axis of the needle.

9. The device (1) according to one of the preceding claims, characterized in that the device (1) comprises locking elements for locking a position of the cleaning station (500) relative to the base station (100).

10. The device (1) according to one of the preceding claims, characterized in that the cleaning station (500), in particular the cleaning device, comprises at least a first and a second needle receptacle (521) having a first and a second opening for receiving the first and the second needle (201) of the fluid manipulation head, and the first and the second needle receptacle (521) preferably further comprising a drain opening (524) and / or inlet opening for the fluid and whereby the fluid manipulation head can be positioned in such a way that the first needle (201) can be positioned in the first needle receptacle (521) and the second needle (201) can be positioned in the second needle receptacle (521).

11. The device (1) according to claim 10, characterized in that the fluid manipulation head comprises at least a first needle (201), a second needle and a sealing structure for sealing a first and a second needle receptacle (521) of a cleaning station (500), when the first needle (201) and the second needle are accommodated in the first and the second needle receptacle (521) respectively, wherein the sealing structure comprises an opening,29084-EP1 - PR / SG / qub Keller Schneider16 December 2025 Patent- und Markenanwaltewherein a first longitudinal axis of the first needle (201) and a second longitudinal axis of the second needle extend through the opening of the sealing structure, and wherein an end face of the sealing structure is formed as a sealing surface, which can interact with a counter sealing surface of the cleaning station, in particular in the form of a face seal.

12. The device (1) according to claim 11, characterized in that the sealing structure comprises a circumferential flange surrounding the opening, and wherein an end face of the circumferential flange is formed as the sealing surface and in particular the circumferential flange is a rigid flange.

13. The device (1) according to claim 11 or 12, characterized in that the cleaning station (500) further comprises a counter sealing structure for interacting with a sealing structure of a fluid manipulation head, wherein the counter sealing structure comprises an opening, wherein a first longitudinal axis of the first needle receptacle (521) and a second longitudinal axis of the second needle receptacle extend through the opening of the counter sealing structure, wherein the counter sealing structure preferably comprises an elastic sealing element.

14. The device (1) according to one of claims 10 to 13, characterized in that the cleaning station (500) further comprises an ultrasonic bath for cleaning the first needle (201), wherein the ultrasonic bath is neighboring and preferably affixed to the at least one first needle receptacle.

15. The device (1) according to one of claims 1 to 14, characterized in that the fluid manipulation head comprises between 2 and 128 needles (201), preferably between 6 and 90, in particular between 8 and 64 needles and the clean station comprises the equivalent number of receptacles for receiving the needles (201) in the cleaning configuration.29084-EP1 - PR / SG / qub Keller Schneider16 December 2025 Patent- und Markenanwalte16. A method for cleaning a needle of a fluid manipulation head using a device (1) for handling a fluid according to one of claims 1 to 15, comprising a base station (100) and a fluid manipulation head with at least a first needle (201) for handling the fluid, and a fluid well holder (400), in particular a well plate-holder, wherein the fluid manipulation head is positionable above the fluid receptacle holder, and wherein the device (1) further comprises a cleaning station (500), characterized by moving the cleaning station (500) relative to the base station (100), moving the needle along a needle longitudinal direction to the cleaning station (500) and cleaning the needle (201) by the cleaning station (500).

17. The method according to claim 16, characterized in that the cleaning station (500) is guided along a first direction on the base station (100) via a first rail guide (110) and the fluid well holder (400) is guided along the first direction on the base station (100) via the first rail guide (110) or a second rail guide .

18. The method according to claim 16 or 17, characterized in that the device (1) comprises a drive for moving the fluid well holder (400) along the first rail guide (110) and the device (1) comprises coupling elements for coupling the cleaning station (500) to the fluid well holder (400), and the cleaning station (500) is connected by the coupling elements, in particular by magnetic coupling elements, to the fluid well holder (400) and the cleaning station (500) is moved automatically by the fluid well holder (400), in particular exclusively moved automatically by the fluid well holder (400).

19. The method according to one of claims 16 to 18, characterized in that, in order to decouple the cleaning station (500) from the fluid well holder (400), the cleaning station (500) is locked by locking elements relative to the base station (100) and the fluid well holder (400) is moved away from the cleaning station (500).

20. The method according to one of the claims 16 to 19, characterized in that the cleaning station (500) comprising a first needle receptacle (521) having a first opening for receiving the first needle (201) of the fluid manipulation head and the first needle receptacle (521) further comprising a drain opening (524) and / or inlet opening for the29084-EP1 - PR / SG / qub Keller Schneider16 December 2025 Patent- und Markenanwaltefluid, whereby the fluid manipulation head is positioned in such a way that the first needle (201) is positioned in the first needle receptacle (521).

21. The method according to claim 20, characterized in that the first needle (201) comprises an area with an enlarged cross-section in a proximal area of the needle, wherein the first needle (201) is introduced into the first needle receptacle (521) in such a way that the area with an enlarged cross-section (202) is sealing the opening of the first needle receptacle (521) in the cleaning configuration.

22. The method according to claim 21, characterized in that the area with enlarged crosssection is designed as a plug (202) having a lateral outer surface and the first needle (201) is introduced into the first needle receptacle (521) in such a way that the plug(202) is sealing the opening of the first needle receptacle (521) in the cleaning configuration between the lateral outer surface and the opening.

23. The method according to claim 22, characterized in that the opening of the first needle receptacle (521) comprises a sealing element (532), in particular an O-ring, wherein the first needle (201) is introduced into the first needle receptacle (521) in such a way that the lateral outer surface of the plug (202) is in contact with the sealing element (532), in order to seal the opening of the at last one needle receptacle (521) in the cleaning configuration.29084-EP1 - PR / SG / qub Keller Schneider16 December 2025 Patent- und Markenanwalte

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