The invention is applied in the industries of medicine, air compression, natural gas, synthetic ammonia, oil refining, coking and the like, and relates to a gas-liquid separation device. The device comprises a shell, an air inlet pipe and an exhaust pipe; a drum driven to rotate by a power device is arranged in the shell; the wall of the drum is provided with air holes; a partition plate is arranged in the drum to partition the drum into an air inlet end and an exhaust end which are respectively communicated with the air inlet pipe and the exhaust pipe; the air inlet pipe is communicated with the exhaust pipe through the air inlet end of the drum, the air holes in the wall of the drum, an air passage and the exhaust end of the drum; and the shell is provided with a drain pipe. Through the device, the separation efficiency of liquid particles with the diameters of over 0.1 micron reaches over 99.5 percent; and the device is large in treated gas quantity and suitable for wet gas with high liquid content, does not require circulation of a large quantity of washing absorption liquid, does not require a high-voltage electrostatic system, has good adaptability to the physical properties of the liquid, has certain capability of separating dry gas components with different densities, and is small in volume, light in weight, small in occupied space and low in manufacturing cost.