Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
By developing substituted benzooxazole and benzofuran compounds as PDE7 inhibitors, the problem of lack of effective treatment methods in the prior art is solved, and effective treatment of neurological and peripheral diseases and improvement of cognitive functions are achieved.
CN111094293BActive Publication Date: 2025-08-01DART NEUROSCIENCE LLC
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Patent Information
- Application Number
- CN201880058047.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2017-07-12
- Filing Date
- 2018-07-11
- Publication Date
- 2025-08-01
- Estimated Expiration
- 2038-07-11
AI Technical Summary
Technical Problem
The lack of effective PDE7 inhibitors in the prior art is unable to meet the treatment needs for neurological and peripheral disorders, especially in regulating cAMP levels and improving cognitive function.
Method used
Substituted benzooxazole and benzofuran compounds were developed as selective PDE7 inhibitors to treat related conditions by regulating cAMP levels.
Benefits of technology
These compounds can effectively inhibit PDE7, enhance neuronal plasticity, reduce inflammation, and are used to treat neurological and peripheral conditions, including mental disorders, cognitive disorders and motor disorders.
✦ Generated by Eureka AI based on patent content.
Abstract
Substituted benzoxazole and benzofuran chemical entities of formula (I): #imgabs0# wherein V, W, X, Y, Z and m have any of the values described herein, and compositions comprising such chemical entities; methods for preparing them; and their use in various methods, including metabolic and reaction kinetics studies; detection and imaging techniques; radiotherapy; and the treatment of one or more conditions, including neurological conditions, cognitive disorders, immune conditions and inflammatory conditions, as well as other conditions and diseases involving PDE7 or cyclic nucleotide signaling.
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