Cleaning device and chemiluminescent immunoassay analyzer

Abstract

The present invention discloses a cleaning device and a chemiluminescent immunoassay analyzer having the same, wherein the cleaning device comprises a frame and a conveying mechanism, a cleaning needle mechanism, and a magnet mechanism arranged on the frame, wherein the frame is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism comprises a turntable and a first driving assembly capable of driving the turntable, wherein the turntable is provided with a cup placement hole for placing a reaction cup, the conveying mechanism can transport the reaction cup to different stations, and the turntable can reciprocate; the cleaning needle mechanism corresponds to the liquid aspiration station and the liquid injection station and can absorb waste liquid from the reaction cup and inject cleaning liquid into the reaction cup; the magnet mechanism comprises at least one active magnet assembly arranged corresponding to the liquid aspiration station, and the active magnet assembly can adsorb the immune complex in the reaction cup to the cup wall and can drive it to move upward. The present invention has a good washing and separation effect on the immune complex and a high working efficiency.

Description

Technical Field

[0001] The invention relates to the field of medical detection, and in particular to a cleaning device and a chemiluminescent immunoassay analyzer. Background Art

[0002] Chemiluminescent immunoassay is an instrument that uses chemiluminescent immunoassay technology and reaction principles to qualitatively or quantitatively detect analytes in human serum, plasma or other body fluid samples. It is used to assist in the diagnosis of related diseases. The effective separation of immune complexes is a key step in immunoassays, and the separation effect will affect the results of immunoassays. At present, in immunoassays that use magnetic beads as reaction carriers, the separation of immune complexes mainly adopts magnetic separation. The magnetic separation method uses immune magnetic beads that have both easy magnetization and specific binding ability to specifically bind to the target substance, and then uses an external magnetic field to retain the reactants (immune complexes) bound to the magnetic beads and separate the excess reactants and reagents.

[0003] The existing cleaning device of the chemiluminescent immunoassay analyzer generally includes a reaction cup conveying component, a cleaning needle component, a magnet component and at least two cleaning positions. The magnet component includes a magnet fixedly arranged corresponding to each liquid aspiration cleaning position. The magnet can adsorb the magnetic beads in the reaction cup to the bottom of the reaction cup. The liquid aspiration needle in the cleaning needle component absorbs the excess reactants and reagents in the cup. The reaction cup conveying component conveys the reaction cup to the next cleaning position, and then the washing liquid is injected into the reaction cup through the injection needle for washing. The above-mentioned cleaning device has a poor washing and separation effect on the immune complex. In order to achieve a better washing and separation effect, some of the existing cleaning devices will be fixedly provided with magnets on both sides of the reaction cup conveying path. When the reaction cup changes the cleaning position, the magnetic beads move from one wall of the reaction cup to the wall opposite to the wall to facilitate the cleaning of the magnetic beads. However, the time for the magnetic beads to move from one wall of the reaction cup to the wall opposite to the wall is relatively long, which greatly affects the work efficiency. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a cleaning device, which has a good washing and separation effect on immune complexes and a high working efficiency.

[0005] The invention also provides a chemiluminescence immunoassay analyzer with the cleaning device.

[0006] According to the first aspect of the present invention, the cleaning device described in the embodiment includes a frame, a conveying mechanism, a cleaning needle mechanism and a magnet mechanism, the frame is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism is arranged on the frame, the conveying mechanism includes a turntable and a first driving component capable of driving the turntable, the turntable is provided with a cup placement hole for placing a reaction cup, the conveying mechanism can transport the reaction cup placed in the cup placement hole to different stations, and the turntable can rotate back and forth; the cleaning needle mechanism is arranged on the frame and corresponds to the liquid aspiration station and the liquid injection station, the cleaning needle mechanism can absorb waste liquid from the reaction cup and can inject cleaning liquid into the reaction cup; the magnet mechanism is arranged on the frame and distributed on at least one side of the reaction cup running path, the magnet mechanism includes at least one active magnet component arranged corresponding to the liquid aspiration station, the active magnet component can adsorb the immune complex in the reaction cup and can drive the immune complex to move upward.

[0007] According to the cleaning device described in the embodiment of the present invention, it has at least the following beneficial effects: by setting a movable magnet assembly and a turntable that can rotate back and forth, when washing and separating the immune complex, the turntable rotates to transport the reaction cup to the liquid aspiration station, the movable magnet assembly adsorbs the immune complex in the reaction cup to the bottom of the cup wall and drives it to move upward so that it is at a preset height from the bottom of the cup, the cleaning needle mechanism absorbs waste liquid from the reaction cup, and the immune complex adsorbed on the cup wall can avoid being affected by the cleaning needle mechanism. After the cleaning needle mechanism completes the waste liquid absorption, the conveying mechanism transports the reaction cup to the liquid injection station, and the cleaning needle mechanism injects cleaning liquid into the reaction cup. Then the turntable rotates back and forth, so that the immune complex adsorbed on the cup wall is shaken and dispersed, which facilitates the immune complex and the injected cleaning liquid to be fully mixed for cleaning, so that the immune complex in the reaction cup obtains a better cleaning effect and achieves a better washing and separation effect; at the same time, it can reduce the washing and separation time of the immune complex, thereby improving the working efficiency of the present invention.

[0008] According to some embodiments of the present invention, the movable magnet assembly includes a movable magnet and a magnet driver connected to the movable magnet, one end of the magnetic pole of the movable magnet is located on one side of the reaction cup running path, and the magnet driver can drive the movable magnet to move up and down along the cup wall of the reaction cup. By setting the movable magnet and the magnet driver, the movable magnet adsorbs the immune complex in the reaction cup, and the magnet driver drives the movable magnet to move, driving the immune complex adsorbed on the cup wall to move. It has a simple structure and a small size, and can better achieve the purpose of adsorbing the immune complex in the reaction cup and driving it to move, which can improve the reliability of the present invention.

[0009] According to some embodiments of the present invention, at least two of the pipetting stations are provided, and the magnet mechanism further includes at least one fixed magnet fixedly provided corresponding to the pipetting station, one end magnetic pole of the fixed magnet is located on one side of the reaction cup running path, and the fixed magnet and the movable magnet assembly are located at different pipetting stations. By providing at least two pipetting stations, and providing the fixed magnet and the movable magnet assembly at different pipetting stations to adsorb the immune complex in the reaction cup, the immune complex can be washed and separated in different modes, so that the present invention can achieve better washing and separation effects. At the same time, the combination of the fixed magnet and the movable magnet assembly can reduce the production cost of the present invention and facilitate production and manufacturing.

[0010] According to some embodiments of the present invention, the distance a between the axis of the cup placement hole and the rotation axis of the turntable is configured as: 40mm≦a≦50mm, and the reciprocating rotation speed b of the turntable is configured as: 550rpm≦b≦650rpm. By setting the distance a between the axis of the cup placement hole and the rotation axis of the turntable in the range of 40mm to 50mm, and the reciprocating rotation speed b of the turntable in the range of 550rpm to 650rpm, when the turntable is in a reciprocating rotation state, the immune complex adsorbed on the cup wall can be shaken well, which facilitates the immune complex to be shaken and dispersed. At the same time, the reaction cup filled with cleaning liquid is shaken well, and the cleaning liquid in the reaction cup is easy to generate a vortex, which is convenient for fully cleaning the immune complex therein, achieving a better cleaning effect, and reducing the required cleaning time.

[0011] According to some embodiments of the present invention, the first drive assembly includes a first drive and a synchronous belt, the synchronous belt is connected to the first drive and the turntable respectively, and the first drive can drive the turntable to rotate through the synchronous belt. By providing the first drive and the synchronous belt, the first drive drives the turntable to rotate through the synchronous belt, and its structure is relatively simple, which can reduce the volume of the present invention, and the synchronous belt transmission is accurate and stable, which can enable the turntable to achieve better positioning and transportation, and at the same time, the cost is low and it is easy to produce and manufacture.

[0012] According to some embodiments of the present invention, the frame is provided with a first position detection component, which can detect the rotation position of the turntable. By setting the first position detection component to detect the rotation position of the turntable, it is possible to avoid the reaction cup being unable to wash and separate the immune complex in a non-cleaning position due to the turntable not rotating properly or rotating excessively, thereby avoiding the occurrence of malfunctions, ensuring the accuracy of the turntable rotation position, and improving the degree of intelligence of the present invention.

[0013] According to some embodiments of the present invention, the cleaning needle mechanism includes a motion platform and a second drive assembly connected to the motion platform, the motion platform is provided with a liquid suction needle assembly that can be connected to an external suction device and an injection needle assembly that can be connected to an external cleaning liquid delivery device, the liquid suction needle assembly is arranged corresponding to the liquid suction station and can suck waste liquid from the reaction cup, the injection needle assembly is arranged corresponding to the injection station and can inject cleaning liquid into the reaction cup, and the second drive assembly can drive the motion platform to move up and down. By setting up a motion platform, the motion platform is provided with a liquid suction needle assembly and a liquid injection needle assembly, and the second drive assembly drives the motion platform to move up and down, which has a simple structure and a small size, can reduce production costs, is easy to manufacture, and can better realize the functions of absorbing waste liquid and injecting cleaning liquid of the cleaning needle mechanism.

[0014] According to some embodiments of the present invention, the frame is provided with a second position detection component, which can detect the moving position of the motion platform. By setting up the second position detection component to detect the moving position of the motion platform, it is possible to avoid abnormal operation of the aspiration needle assembly and the injection needle assembly due to the motion platform not moving in place or moving excessively, thereby avoiding the occurrence of faults, ensuring the accuracy of the moving position of the motion platform, and improving the degree of intelligence of the present invention.

[0015] According to some embodiments of the present invention, the frame is also provided with a dripping station, and the moving platform is provided with a dripping needle assembly that can be connected to an external luminescent liquid delivery device. The dripping needle assembly is arranged corresponding to the dripping station and can drip luminescent liquid into the reaction cup. By setting the dripping needle assembly, after the immune complex in the reaction cup is washed and separated, the luminescent liquid can be dripped to the immune complex in the reaction cup through the dripping needle assembly, which is convenient for the subsequent chemiluminescent immunoassay detection of the immune complex in the reaction cup, avoiding the trouble of setting up an additional dripping device in the future, and improving the convenience and functionality of the present invention.

[0016] The chemiluminescent immunoassay analyzer according to the second aspect of the present invention comprises the cleaning device according to the first aspect of the present invention.

[0017] The chemiluminescent immunoassay analyzer according to the embodiment of the present invention has at least the following beneficial effects: by adopting the above-mentioned cleaning device, it has a better washing and separation effect on the immune complex, which can improve the accuracy of immunoassay detection, obtain better immunoassay results, and improve the reliability of the detection results. At the same time, it is small in size and can reduce the occupied space. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0019] Figure 1 It is a schematic structural diagram of a cleaning device according to an embodiment of the first aspect of the present invention;

[0020] Figure 2 for Figure 1 Schematic diagram of the exploded structure of the cleaning device;

[0021] Figure 3 for Figure 1 A schematic diagram of the front view of the cleaning device;

[0022] Figure 4 for Figure 1 A schematic cross-sectional structure diagram of the cleaning device in a first state;

[0023] Figure 5 for Figure 4 A magnified schematic diagram of part A;

[0024] Figure 6 for Figure 1 A schematic cross-sectional structure diagram of the cleaning device in a second state;

[0025] Figure 7 for Figure 6 Schematic diagram of the enlarged portion B.

[0026] Reference numerals:

[0027] Rack 100;

[0028] Conveying mechanism 200, turntable 210, cup placement hole 211, first driving assembly 220, first driver 221, synchronous belt 222;

[0029] Cleaning needle mechanism 300, motion platform 310, second drive assembly 320, second driver 321, connecting rod assembly 322, aspiration needle assembly 330, aspiration needle tube 331, first connecting piece 332, injection needle assembly 340, injection needle tube 341, second connecting piece 342, dripping needle assembly 350, dripping needle tube 351, third connecting piece 352;

[0030] The magnet mechanism 400, the movable magnet assembly 410, the movable magnet 411, the magnet driver 412, the guide 413, and the fixed magnet 420;

[0031] Reaction cup 1, distance a. DETAILED DESCRIPTION

[0032] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0033] In the description of the present invention, it should be understood that descriptions involving orientation, such as orientation or positional relationship indicated as up, down, etc., are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0034] In the description of the present invention, “several” means one or more, “more” means more than two, “greater than”, “less than”, “exceed”, etc. are understood as not including the number itself, and “above”, “below”, “within”, etc. are understood as including the number itself.

[0035] If the first and second are described, they are only used to distinguish the technical features and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the sequence of the indicated technical features.

[0036] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0037] According to the first embodiment of the present invention, referring to Figure 1 and Figure 2 A cleaning device includes a frame 100, a conveying mechanism 200, a cleaning needle mechanism 300 and a magnet mechanism 400. The frame 100 is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism 200 is arranged on the frame 100, and the conveying mechanism 200 includes a turntable 210 and a first driving assembly 220 capable of driving the turntable 210. The turntable 210 is provided with a cup placement hole 211 for placing a reaction cup 1. The conveying mechanism 200 can transport the reaction cup 1 placed in the cup placement hole 211 to different stations, and the turntable 210 can move to the first driving assembly 220. The cleaning needle mechanism 300 is arranged on the frame 100 and corresponds to the liquid aspiration station and the liquid injection station. The cleaning needle mechanism 300 can absorb waste liquid from the reaction cup 1 and can inject cleaning liquid into the reaction cup 1; the magnet mechanism 400 is arranged on the frame 100 and distributed on at least one side of the running path of the reaction cup 1. The magnet mechanism 400 includes at least one active magnet assembly 410 arranged corresponding to the liquid aspiration station. The active magnet assembly 410 can absorb the immune complex in the reaction cup 1 and can drive the immune complex to move upward.

[0038] By providing a movable magnet assembly 410 and a reciprocating turntable 210, when washing and separating the immune complex, the turntable 210 rotates to transport the reaction cup 1 to the liquid aspiration station, the movable magnet assembly 410 adsorbs the immune complex in the reaction cup 1 to the bottom of the cup wall and drives it to move upward so that it is at a preset height from the bottom of the cup, the cleaning needle mechanism 300 absorbs waste liquid from the reaction cup 1, and the immune complex adsorbed on the cup wall can avoid being affected by the cleaning needle mechanism. After the cleaning needle mechanism 300 completes the waste liquid absorption, the transport mechanism 200 transports the reaction cup 1 to the liquid injection station, and the cleaning needle mechanism 300 injects cleaning liquid into the reaction cup 1. Then the turntable 210 reciprocates, so that the immune complex adsorbed on the cup wall is shaken and dispersed, which facilitates the immune complex and the injected cleaning liquid to be fully mixed for cleaning, so that the immune complex in the reaction cup 1 obtains a better cleaning effect and achieves a better washing and separation effect; at the same time, it can reduce the washing and separation time of the immune complex, thereby improving the working efficiency of the present invention.

[0039] In this embodiment, if Figure 1 and Figure 2 As shown, eleven cup placement holes 211 are provided on the turntable 210 and are evenly spaced along the circumference of the turntable 210. The reaction cup 1 passes through the cup placement holes 211 and is clamped and placed on the turntable 210. The first driving component 220 drives the turntable 210 to rotate so that the reaction cup 1 placed thereon can be transported to the liquid aspiration station and the liquid injection station; when the reaction cup 1 is sent to the liquid aspiration station, the active magnet component 410 adsorbs the immune complex in the reaction cup 1 on the cup wall of the reaction cup 1 and drives it to move upward to a position at a preset height from the bottom of the cup, and the cleaning needle mechanism 300 is activated to absorb waste liquid from the reaction cup 1 at this station. The active magnet component 410 adsorbs the immune complex and retains it on the cup wall of the reaction cup 1 to separate it from the waste liquid, and at the same time can prevent the cleaning needle mechanism 300 from extending into the cup bottom of the reaction cup 1 to absorb liquid. The immune complex in the cup is affected, and then the cleaning needle mechanism 300 completes the waste liquid absorption and leaves the reaction cup 1. The conveying mechanism 200 conveys the reaction cup 1 to the liquid injection station. At this time, due to the viscosity of the immune complex and the liquid in the reaction cup 1 being sucked away, the immune complex in the reaction cup 1 is still adsorbed at a preset height position on the cup wall of the reaction cup 1. The cleaning needle mechanism 300 injects cleaning liquid into the reaction cup 1. After the liquid injection is completed, the cleaning needle mechanism 300 leaves the reaction cup 1, and the turntable 210 starts to rotate back and forth. Since the cup is injected with cleaning liquid, the immune complex on the cup wall is shaken back and forth and dispersed under the reciprocating rotation of the turntable 210 and the action of gravity, so that the immune complex can be fully mixed with the injected cleaning liquid for cleaning, thereby obtaining a better cleaning effect and reducing the time required for cleaning.

[0040] In actual application, three, four or more liquid aspiration stations and liquid injection stations can be set. There are many ways for the first drive component 220 to drive the turntable 210 and to realize the reciprocating rotation of the turntable 210. The specific structures of the cleaning needle mechanism 300 and the movable magnet assembly 410 can also be set according to actual use needs. They are not described in detail here and are explained in detail below.

[0041] In some embodiments, the movable magnet assembly 410 includes a movable magnet 411 and a magnet driver 412 that is driven and connected to the movable magnet 411. One end of the magnetic pole of the movable magnet 411 is located on one side of the running path of the reaction cup 1. The magnet driver 412 can drive the movable magnet 411 to move up and down along the cup wall of the reaction cup 1. By setting the movable magnet 411 and the magnet driver 412, the movable magnet 411 adsorbs the immune complex in the reaction cup 1, and the magnet driver 412 drives the movable magnet 411 to move, driving the immune complex adsorbed on the cup wall to move. It has a simple structure and a small volume, and can better achieve the purpose of adsorbing the immune complex in the reaction cup 1 and driving it to move, which can improve the reliability of the present invention.

[0042] In this embodiment, if Figure 1 , Figure 4 and Figure 6 As shown, the movable magnet assembly 410 is provided with one and is located outside the running path of the reaction cup 1, and it also includes a guide member 413, and the guide member 413 is provided with a guide groove, and the movable magnet 411 is arranged in the guide groove, and one end of the magnetic pole of the movable magnet 411 is close to the running path of the reaction cup 1, and when the reaction cup 1 is transported to the liquid aspiration station, one end of the magnetic pole of the movable magnet 411 is located close to the cup wall of the reaction cup 1, and the magnet driver 412 is a linear motor, and the movable magnet 411 can be driven by the magnet driver 412 to move up and down along the guide groove. Figure 4 and Figure 5 As shown in the figure, the present invention is in the working state when the conveying mechanism 200 conveys the reaction cup to the liquid aspiration station, the cleaning needle mechanism 300 has not yet sucked the waste liquid, the active magnet 411 is close to the cup wall of the reaction cup 1 on the station, and the immune complex (not shown in the figure) in the reaction cup 1 is adsorbed at a position near the cup wall near the bottom of the cup, and then the active magnet 411 is driven by the magnet driver 412 to move upward to a preset height position, driving the immune complex to move upward along the cup wall to a position at a preset height from the cup bottom, as shown in FIG. Figure 6 and Figure 7As shown, the present invention is in the working state of the cleaning needle mechanism 300 in the process of sucking waste liquid. The movable magnet 411 adsorbs the immune complex and retains it on the wall of the reaction cup 1 to separate it from the waste liquid. At the same time, it can prevent the cleaning needle mechanism 300 from extending into the bottom of the reaction cup 1 to suck liquid and affecting the immune complex in the cup, and facilitate the subsequent reciprocating rotation of the turntable 210 to shake the immune complex apart after the cleaning liquid is injected into the reaction cup 1.

[0043] In actual application, the movable distance of the active magnet 411 can be set according to actual use needs. In addition to directly driving the active magnet 411 to move through the magnet driver 412, a connecting rod structure, a slider structure, etc. can also be set to move the active magnet 411. The magnet driver 412 is not limited to a linear motor, and the active magnet 411 can also be driven to move by a servo motor and a screw structure or a gear rack structure. The guide member 413 can also be set according to actual use needs. The specific structure of the active magnet assembly 410 can be changed according to actual use needs, which can be understood by those skilled in the art and is not limited here.

[0044] In some embodiments, at least two liquid aspiration stations are provided, and the magnet mechanism 400 further includes at least one fixed magnet 420 fixedly provided corresponding to the liquid aspiration station, one end of the magnetic pole of the fixed magnet 420 is located on one side of the running path of the reaction cup 1, and the fixed magnet 420 and the movable magnet assembly 410 are located at different liquid aspiration stations. By providing at least two liquid aspiration stations, and providing the fixed magnet 420 and the movable magnet assembly 410 at different liquid aspiration stations to adsorb the immune complex in the reaction cup 1, the immune complex can be washed and separated in different modes, so that the present invention can achieve a better washing and separation effect. At the same time, the use of the fixed magnet 420 and the movable magnet assembly 410 can reduce the production cost of the present invention and facilitate production and manufacturing.

[0045] In this embodiment, if Figure 1 and Figure 2 As shown, there are four pipetting stations, and the magnet mechanism 400 includes a movable magnet assembly 410 and three fixed magnets 420, which are respectively distributed corresponding to the four pipetting stations. The movable magnet assembly 410 and the three fixed magnets 420 are all located outside the running path of the reaction cup 1, and one end of the fixed magnet 420 is close to the running path of the reaction cup 1. When the reaction cup 1 is transported to the pipetting station, one end of the fixed magnet 420 is close to the wall of the reaction cup 1.

[0046] In actual application, the specific number of pipetting stations, active magnet assemblies 410 and fixed magnets 420 can be set according to actual use needs. For example, three pipetting stations, two active magnet assemblies 410 and one fixed magnet 420 are set. Their distribution positions can also be set according to actual use needs, such as the active magnet assemblies 410 and the fixed magnets 420 are distributed on the same side of the running path of the reaction cup 1 or are respectively distributed on both sides of the running path of the reaction cup 1, etc., and there is no limitation here.

[0047] In some embodiments, the distance a between the axis of the cup placement hole 211 and the rotation axis of the turntable 210 is configured as: 40mm≦a≦50mm, and the reciprocating rotation speed b of the turntable 210 is configured as: 550rpm≦b≦650rpm. By setting the distance a between the axis of the cup placement hole 211 and the rotation axis of the turntable 210 in the range of 40mm to 50mm, and the reciprocating rotation speed b of the turntable 210 in the range of 550rpm to 650rpm, when the turntable 210 is in a reciprocating rotation state, the immune complex adsorbed on the cup wall can be shaken well, so that the immune complex is shaken and dispersed, and at the same time, the reaction cup 1 filled with the cleaning liquid is shaken well, and the cleaning liquid in the reaction cup 1 is easy to generate a vortex, which is convenient for fully cleaning the immune complex therein, achieving a better cleaning effect, and reducing the required cleaning time.

[0048] In this embodiment, if Figure 6 As shown, the distance a between the axis of the cup placement hole 211 and the rotation axis of the turntable 210 is 45 mm, and the reciprocating rotation speed b of the turntable 210 is 600 rpm, so that the immune complex can achieve a better shaking and dispersion effect and a cleaning effect when the turntable 210 reciprocates. In actual application, the distance a between the axis of the cup placement hole 211 and the rotation axis of the turntable 210 and the reciprocating rotation speed b of the turntable 210 can be selected and set within the above value range according to actual use needs, such as setting the distance a to 40 mm and the reciprocating rotation speed b to 550 rpm, or setting the distance a to 50 mm and the reciprocating rotation speed b to 650 rpm, which are not limited here and can be understood by those skilled in the art.

[0049] In some embodiments, the first drive assembly 220 includes a first driver 221 and a synchronous belt 222, and the synchronous belt 222 is connected to the first driver 221 and the turntable 210 respectively, and the first driver 221 can drive the turntable 210 to rotate through the synchronous belt 222. By providing the first driver 221 and the synchronous belt 222, the first driver 221 drives the turntable 210 to rotate through the synchronous belt 222, and its structure is relatively simple, which can reduce the volume of the present invention, and the synchronous belt 222 drives accurately and stably, which can enable the turntable 210 to achieve better positioning and transportation, and at the same time, the cost is low and it is easy to produce.

[0050] In this embodiment, if Figure 2 , Figure 4 and Figure 6 As shown, the first driver 221 is a stepper motor. The first driver 221 drives the turntable 210 to rotate through the synchronous belt 222 to realize the conveyance of the reaction cup 1. The first driver 221 can be changed between forward and reverse rotation to realize the reciprocating rotation of the turntable 210. The present invention realizes the conveyance and shaking of the reaction cup 1 through the provision of a driver, and its volume is small and the cost can be reduced. In actual application, the conveyance of the reaction cup 1 by the conveying mechanism 200 can also be realized by setting the cooperation of the cam indexer and the drive motor, and two or more different drive motors and a clutch mechanism can also be set. The clutch mechanism controls the connection or disconnection between the turntable 210 and different drive motors, so as to realize the conveyance and shaking of the reaction cup 1 by the turntable 210. The specific setting can be made according to the actual use needs, and those skilled in the art can understand it.

[0051] In some embodiments, a first position detection component (not shown in the figure) is provided on the frame 100, and the first position detection component can detect the rotation position of the turntable 210. By setting the first position detection component to detect the rotation position of the turntable 210, it is possible to avoid the turntable 210 from rotating incompletely or rotating excessively, resulting in the reaction cup 1 being in a non-cleaning position and being unable to wash and separate the immune complex, thereby avoiding the occurrence of malfunctions, ensuring the accuracy of the rotation position of the turntable 210, and improving the degree of intelligence of the present invention.

[0052] In this embodiment, the first position detection component includes a photoelectric sensor, and a detection point (not shown in the figure) is set on the turntable 210. The photoelectric sensor is set on the frame 100 at the rotation position corresponding to the turntable 210 to be detected. The photoelectric sensor detects whether the turntable 210 is rotated to the specified position to avoid the turntable 210 not rotating to the specified position and the cleaning needle mechanism 300 is operating and causing a malfunction. In actual application, the specific structure of the first position detection component can be set accordingly according to actual use needs, and in addition to the photoelectric sensor, the first position detection component can also use detection elements such as micro switches, infrared sensors, Hall sensors, etc., which are not limited here.

[0053] In some embodiments, the cleaning needle mechanism 300 includes a motion platform 310 and a second driving assembly 320 drivingly connected to the motion platform 310. The motion platform 310 is provided with a liquid suction needle assembly 330 that can be connected to an external suction device and a liquid injection needle assembly 340 that can be connected to an external cleaning liquid delivery device. The liquid suction needle assembly 330 is arranged corresponding to the liquid suction station and can suck waste liquid from the reaction cup 1. The liquid injection needle assembly 340 is arranged corresponding to the liquid injection station and can inject cleaning liquid into the reaction cup 1. The second driving assembly 320 can drive the motion platform 310 to move up and down. By setting the motion platform 310, the motion platform 310 is provided with the liquid suction needle assembly 330 and the liquid injection needle assembly 340, and the second driving assembly 320 drives the motion platform 310 to move up and down. It has a simple structure and a small volume, can reduce production costs, is easy to manufacture, and can better realize the functions of sucking waste liquid and injecting cleaning liquid of the cleaning needle mechanism 300.

[0054] In this embodiment, if Figure 1 , Figure 2 and Figure 3As shown, the frame 100 is provided with three injection stations, and the four pipetting stations and the three injection stations are arranged alternately and spaced apart, and the motion platform 310 is provided with four pipetting needle assemblies 330 and three injection needle assemblies 340, and the four pipetting needle assemblies 330 correspond to the four pipetting stations and the three injection needle assemblies 340 correspond to the three injection stations, respectively, and the pipetting needle assembly 330 includes a pipetting needle tube 331 and a first connecting member 332 fixedly connected thereto, and the first connecting member 332 is connected to the first connecting member 332 by a thread. The moving platform 310 is connected, the aspiration needle tube 331 is detachably mounted on the moving platform 310 through the first connecting piece 332, the injection needle assembly 340 includes an injection needle tube 341 and a second connecting piece 342 fixedly connected thereto, the second connecting piece 342 is connected to the moving platform 310 through a thread, and the injection needle tube 341 is detachably mounted on the moving platform 310 through the second connecting piece 342. When used, the aspiration needle tube 331 and the injection needle tube 341 are respectively connected to the corresponding suction equipment and The second driving assembly 320 includes a second driving assembly 321 and a connecting rod group 322. The motion platform 310 is fixedly connected to the connecting rod group 322. The second driving assembly 321 is connected to the connecting rod group 322 through a screw structure. The second driving assembly 321 can be a stepping motor or a servo motor. The second driving assembly 321 moves the connecting rod group 322 up and down through the screw structure, driving the motion platform 310 to move up and down, so that the aspiration needle assembly 330 and the injection needle assembly 340 can move up and down. The aspiration needle tube 331 can be inserted into the reaction cup 1 and absorb the waste liquid through an external suction device. The injection needle tube 341 can be inserted into the reaction cup 1 and inject the cleaning liquid into the reaction cup 1 through an external cleaning liquid delivery device. After the cleaning needle mechanism 300 completes the action, it leaves the reaction cup 1, and then the turntable 210 starts to rotate back and forth, so that the immune complexes in the reaction cups 1 at different stations are shaken and dispersed to achieve sufficient cleaning, improve the cleaning effect, and shorten the time required for cleaning.

[0055] In actual application, the specific structural form of the cleaning needle mechanism 300 is not limited to this. For example, a manipulator can be set to individually control the movement of each aspiration needle assembly 330 or injection needle assembly 340. The second drive assembly 320 can also be a linear motor to directly drive the motion platform 310 to move up and down. The specific structure of the aspiration needle assembly 330 or the injection needle assembly 340 can also be changed according to actual use needs. Those skilled in the art can understand that no limitation is made here.

[0056] In some embodiments, a second position detection component is provided on the frame 100, and the second position detection component can detect the moving position of the motion platform 310. By setting the second position detection component to detect the moving position of the motion platform 310, it is possible to avoid the motion platform 310 from moving inadequately or moving excessively, which may cause abnormal operation of the aspiration needle assembly 330 and the injection needle assembly 340, thereby avoiding the occurrence of faults, ensuring the accuracy of the moving position of the motion platform 310, and improving the degree of intelligence of the present invention.

[0057] In this embodiment, the second position detection component includes a photoelectric sensor, and a detection point (not shown in the figure) is set on the motion platform 310. The photoelectric sensor is set at the moving position corresponding to the motion platform 310 to be detected on the frame 100. The photoelectric sensor detects whether the motion platform 310 has moved to the specified position, so as to avoid failure of the reaction cup 1 to extract or inject liquid when the motion platform 310 has not moved to the specified position. In actual application, the specific structure of the second position detection component can be set according to actual use needs, and in addition to the photoelectric sensor, the second position detection component can also use detection elements such as travel switches, micro switches, infrared sensors, Hall sensors, etc., which are not limited here.

[0058] In some embodiments, a liquid dropping station is further provided on the rack 100, and a liquid dropping needle assembly 350 that can be connected to an external luminescent liquid delivery device is provided on the motion platform 310. The liquid dropping needle assembly 350 is provided corresponding to the liquid dropping station and can drip luminescent liquid into the reaction cup 1. By providing the liquid dropping needle assembly 350, after the immune complex in the reaction cup 1 is washed and separated, the luminescent liquid can be dripped onto the immune complex in the reaction cup 1 through the liquid dropping needle assembly 350, which facilitates the subsequent chemiluminescent immunoassay detection of the immune complex in the reaction cup 1, avoids the trouble of additionally providing a liquid dropping device, and improves the convenience and functionality of the present invention.

[0059] In this embodiment, if Figure 1 , Figure 2 and Figure 3As shown, a dripping station is provided on the frame 100, and a dripping needle assembly 350 is provided on the motion platform 310. The dripping needle assembly 350 includes a dripping needle tube 351 and a third connecting member 352 fixedly connected thereto. The third connecting member 352 is connected to the motion platform 310 through a thread. The dripping needle tube 351 is detachably mounted on the motion platform 310 through the third connecting member 352. When used, the dripping needle tube 351 is connected to the corresponding luminescent liquid delivery device and moves up and down with the motion platform 310, so that the dripping needle tube 351 can be extended into the reaction cup 1 and drip the chemiluminescent bottom liquid into the reaction cup 1 through the external luminescent liquid delivery device. In actual application, the number and specific structure of the dripping needle assembly 350 can be set accordingly according to actual use needs, which can be understood by those skilled in the art and is not limited here.

[0060] The chemiluminescent immunoassay analyzer (not shown in the figure) according to the second embodiment of the present invention comprises a cleaning device according to the first embodiment of the present invention.

[0061] The chemiluminescent immunoassay analyzer according to the embodiment of the present invention has a better washing and separation effect on the immune complex by adopting the above-mentioned cleaning device, which can improve the accuracy of immunoassay detection, obtain better immunoassay results, and improve the reliability of the detection results. At the same time, it is small in size and can reduce the occupied space.

[0062] Since other components of the chemiluminescent immunoassay analyzer according to the embodiment of the present invention are known to those skilled in the art, they will not be described in detail here.

[0063] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. A cleaning device, characterized in that: include: A frame (100), wherein a liquid aspiration station and a liquid injection station are provided on the frame (100); A conveying mechanism (200) is arranged on the frame (100), comprising a turntable (210) and a first driving assembly (220) capable of driving the turntable (210); the turntable (210) is provided with a cup placement hole (211) for placing a reaction cup (1); the first driving assembly (220) comprises a first driver (221) and a synchronous belt (222); the synchronous belt (222) is connected to the first driver (221) and the turntable (210) respectively; the first driver (221) can drive the turntable (210) to rotate via the synchronous belt (222) so as to convey the reaction cup (1) placed in the cup placement hole (211) to different workstations; the turntable (210) can rotate back and forth; a cleaning needle mechanism (300) arranged on the frame (100) and corresponding to the liquid aspiration station and the liquid injection station, the cleaning needle mechanism (300) comprising a motion platform (310) and a second drive assembly (320) drivingly connected to the motion platform (310); the motion platform (310) is provided with a liquid aspiration needle assembly (330) capable of being connected to an external suction device and a liquid injection needle assembly (340) capable of being connected to an external cleaning liquid delivery device; the liquid aspiration needle assembly (330) is arranged corresponding to the liquid aspiration station and is capable of aspirating waste liquid from the reaction cup (1); the liquid injection needle assembly (340) is arranged corresponding to the liquid injection station and is capable of injecting cleaning liquid into the reaction cup (1); the second drive assembly (320) is capable of driving the motion platform (310) to move up and down; A magnet mechanism (400) is arranged on the frame (100) and distributed on at least one side of the running path of the reaction cup (1), the magnet mechanism (400) comprising at least one movable magnet assembly (410) arranged corresponding to the liquid aspiration station, the movable magnet assembly (410) comprising a movable magnet (411) and a magnet driver (412) drivingly connected to the movable magnet (411), one end of the magnetic pole of the movable magnet (411) being located on one side of the running path of the reaction cup (1), the magnet driver (412) being capable of driving the movable magnet (411) to move up and down along the wall of the reaction cup (1), so that the movable magnet assembly (410) can absorb the immune complex in the reaction cup (1) and drive the immune complex to move upward; At least two of the liquid pipetting stations are provided, and the magnet mechanism (400) further comprises at least one fixed magnet (420) fixedly arranged corresponding to the liquid pipetting station, a magnetic pole at one end of the fixed magnet (420) being located on one side of the running path of the reaction cup (1), and the fixed magnet (420) and the movable magnet assembly (410) being located at different liquid pipetting stations.

2. The cleaning device according to claim 1, characterized in that: The distance a between the axis of the cup placement hole (211) and the rotation axis of the turntable (210) is configured as: 40 mm≦a≦50 mm, and the reciprocating rotation speed b of the turntable (210) is configured as: 550 rpm≦b≦650 rpm.

3. The cleaning device according to claim 1, characterized in that: The frame (100) is provided with a first position detection component, and the first position detection component is capable of detecting the rotation position of the turntable (210).

4. The cleaning device according to claim 1, characterized in that: The frame (100) is provided with a second position detection component, and the second position detection component is capable of detecting the moving position of the motion platform (310).

5. The cleaning device according to claim 1, characterized in that: The frame (100) is also provided with a liquid dropping station, and the motion platform (310) is provided with a liquid dropping needle assembly (350) that can be connected to an external luminescent liquid delivery device. The liquid dropping needle assembly (350) is arranged corresponding to the liquid dropping station and can drip luminescent liquid into the reaction cup (1).

6. A chemiluminescent immunoassay analyzer, characterized in that: The invention comprises a cleaning device according to any one of claims 1 to 5.

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