A handheld coating extrusion device for storing personalized drug formulations

Abstract

The present invention relates to a handheld coating and extrusion device for storing personalized drug preparations. The personalized drug preparation device of the present invention is used to provide accurate amounts of drugs according to the physiological characteristics and needs of patients and the health data of patients. The excipient is in a pre-rolled form, and the soluble drug (API) is deposited on the auxiliary material roll through a drug dispenser mechanism. Before rolling into a roll, a ceramic heater is used to heat the final formula, and then a stepper motor rolls again to extrude the API with a specific amount of drug together with the auxiliary material roll into a roll, which is administered and swallowed as a normal oral drug, thereby customizing personalized drugs. The device is compact and can be handheld.

Description

Technical Field

[0001] The invention relates to a handheld coating extrusion device for storing personalized drug preparations, belonging to the technical field of drug preparation. Background Art

[0002] Typically when making pharmaceutical products, there are pre-formulated drugs available as pills, which cannot be personalized to a certain extent because they are integer concentrations and fractional amounts of concentration will be lost in the manufacturer's product line. To this end, the present invention provides a device to produce personalized pharmaceutical preparations. Summary of the invention

[0003] In view of the shortcomings of the prior art, the present invention provides a handheld coating extrusion device for storing personalized drug preparations. The device makes personalized drug preparations based on the input of patient health data and calculates the final preparation by changing the rotation speed, deposition (coating) flow rate and heating intensity. The present invention provides the possibility of avoiding drug abuse, portability and personalized drug preparation, and also helps to improve the therapeutic efficacy of the excavation itself.

[0004] The technical solution of the present invention is as follows:

[0005] A handheld coating extrusion device for storing personalized pharmaceutical preparations, comprising an auxiliary material roll mechanism, a support mechanism, a heating mechanism, a drug dispensing mechanism, and a stepping motor;

[0006] The auxiliary material roll mechanism is used to provide auxiliary material rolls, and the supporting mechanism includes a conveyor belt. An auxiliary material roll mechanism is provided at one end of the conveyor belt, and the auxiliary material roll is placed above the conveyor belt;

[0007] The drug dispensing mechanism includes a drug dispenser and a microfluidic device, wherein the drug dispenser is used to deliver the drug fluid to be produced to the microfluidic device, and the microfluidic device is used to evenly lay the drug fluid to be produced on the auxiliary material roll to form a drug coating;

[0008] The heating mechanism is located under the conveyor belt and is used to heat the drug coating to make it amorphous; the stepper motor is located at the end of the conveyor belt in the direction of travel and is used to control the moving speed of the auxiliary material roll.

[0009] An excipient roll with defined thickness and width is fed onto a conveyor belt, and then the drug is coated on the excipient roll using a drug dispenser and a microfluidic device, heated by a heating mechanism, and then the stepper motor rolls again to extrude the excipient roll together with a specific amount of drug API into a roll for normal oral administration and swallowing.

[0010] Preferably, the auxiliary material roll is a film made of an excipient or a commercially available film, and the thickness of the auxiliary material roll is uniform and consistent. The excipient includes a plasticizer, a film former, and additional additives. The bottom of the auxiliary material roll is an electrospun fiber or a non-woven fabric or a wet-cast polymer matrix, which is rolled into a cylindrical shape with many layers (about 3-5 meters depending on the application).

[0011] Preferably, the drug dispenser is a syringe pump, one end of the syringe pump is connected to the drug fluid storage, and the other end is connected to the microfluidic device. The drug fluid is delivered to the microfluidic device through the syringe pump.

[0012] Further preferably, the number of the drug dispenser is at least one. A plurality of drug dispensers can be connected to a plurality of drug barrels, different drug barrels can contain different drugs, and different drug fluids are delivered to the microfluidic device together via different drug dispensers.

[0013] Preferably, the microfluidic device comprises at least two channels, each of which has the same width, for uniformly coating the drug fluid on the auxiliary material roll over a period of time.

[0014] Further preferably, the microfluidic device is an L-shaped plate, the side wall of the plate is provided with an inlet horizontally, a channel is provided vertically in the plate, the channel outlet is downward, and the inlet is connected to the drug dispenser. The drug fluid in the drug dispenser enters the channel from the inlet and flows downward through the channel onto the auxiliary material roll.

[0015] Further preferably, the channel outlet is provided with an end plug. The coating width of the microfluidic channel can be controlled by changing the outlet of the microfluidic device.

[0016] Further preferably, a temperature sensor is provided in the channel of the microfluidic device, and a temperature regulating device is provided on the side wall of the plate to deliver a drug fluid with a settable temperature.

[0017] Preferably, the heating mechanism is a ceramic heater.

[0018] Preferably, the support mechanism further comprises a support frame, on which a transmission wheel is provided, the transmission wheel is connected to the conveyor belt, and the transmission wheel is controlled to rotate by a motor. The conveyor belt is driven to move horizontally by the transmission wheel. The transmission wheel can be driven by a compact 6v28BYJ 48 single-stage motor.

[0019] Preferably, the handheld coating extrusion device for storing personalized drug preparations further comprises a microcontroller, which is connected to the drug dispenser, the heating mechanism, the motor, and the stepper motor. The microcontroller controls the flow rate, heating temperature, and motor speed of the injection pump.

[0020] Preferably, the speed of the stepper motor is the same as that of the support mechanism motor. Both motors rotate at the same speed as the feed, and the rotation should move synchronously, otherwise perfect scrolling will not be formed.

[0021] The device is used to formulate personalized drug dosage, and the final concentration of the drug is defined as follows:

[0022] -Concentration of drug in the drug dispenser (to be applied)

[0023] - Speed ​​of drug dispensing

[0024] - Volume of drug dispensed

[0025] -Rotation speed of auxiliary material roll

[0026] Dispensed drug (final formulation) = RPM (speed of stepper motor) * surface area of ​​dispensed auxiliary material roll (length * width (constant)) * flow rate * amount of dispensed drug.

[0027] The beneficial effects of the present invention are:

[0028] The device can be used with two 5v stepper motors and controlled by a microcontroller, and the relationship between API flow rate and rotation speed is plotted, and an equation is fitted for the final formula. Using the device of the present invention, the final product is composed of a film roll containing a specific amount of drug, which can be administered and swallowed as a normal oral drug, and customized personalized drugs. The device is compact and can be handheld, which will bring innovation in the pharmaceutical industry. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0030] Figure 2-1 It is a schematic diagram of the three-dimensional structure of the top surface of the supporting mechanism;

[0031] Figure 2-2 is a side view schematic diagram of the support mechanism;

[0032] Figure 2-3 It is a schematic diagram of the three-dimensional structure of the back of the supporting mechanism;

[0033] Figure 2-4 It is a top view schematic diagram of the support mechanism;

[0034] Figure 2-5 It is a schematic diagram of the end of the support mechanism;

[0035] Figure 3 Provide a connection diagram for the microcontroller;

[0036] Figure 4-1 is a schematic diagram of the front view of the microfluidic device structure;

[0037] Figure 4-2 It is a schematic diagram of the left side view of the microfluidic device structure;

[0038] Figure 4-3is a schematic diagram of the right side view of the microfluidic device structure;

[0039] Figure 4-4 It is a schematic top view of the microfluidic device structure;

[0040] Figure 4-5 It is a bottom view schematic diagram of the microfluidic device structure;

[0041] Figure 5-1 It is a schematic diagram of the main view of the injection pump structure;

[0042] Figure 5-2 It is a schematic diagram of the structure of the injection pump from above;

[0043] Figure 5-3 It is a schematic diagram of the top view of the injection pump structure;

[0044] Figure 5-4 It is a left view schematic diagram of the injection pump structure;

[0045] Figure 5-5 It is a right view schematic diagram of the injection pump structure;

[0046] Figure 5-6 It is a three-dimensional schematic diagram of the injection pump structure;

[0047] Figure 6 This is a schematic diagram of the auxiliary material roll structure;

[0048] Figure 7 It is a schematic diagram of the unfolding layer of the auxiliary material roll;

[0049] Among them: 1. auxiliary material rolling mechanism, 2. supporting mechanism, 3. drug dispenser, 4. microfluidic device, 4-1, inlet, 4-2, channel, 4-3, outlet, 5. heating mechanism, 6. supporting mechanism, 7. stepping motor. DETAILED DESCRIPTION

[0050] The present invention will be further described below by way of embodiments in conjunction with the accompanying drawings, but is not limited thereto.

[0051] Embodiment 1:

[0052] A hand-held coating extrusion device for depositing personalized pharmaceutical formulations, such as Figure 1 As shown, it includes an auxiliary material roll mechanism 1, a supporting mechanism 2, a heating mechanism 5, a medicine dispensing mechanism, and a stepping motor 7.

[0053] The auxiliary material roll mechanism is used to provide auxiliary material rolls. The support mechanism includes a conveyor belt and a support frame. The support frame is provided with a conveyor wheel, which is connected to the conveyor belt and rotated by a motor. The conveyor belt is driven by the conveyor wheel to move horizontally. The drive of the conveyor wheel can be realized by a compact 6v 28BYJ 48 single-stage motor, such as Figure 2-1 to Figure 2-5As shown, an auxiliary material roll mechanism is provided at one end of the conveyor belt, and the auxiliary material roll is placed above the conveyor belt.

[0054] The drug dispensing mechanism includes a drug dispenser 3 and a microfluidic device 4. The drug dispenser 3 is used to deliver the drug fluid to be produced to the microfluidic device 4. The microfluidic device 4 is used to evenly spread the drug fluid to be produced on the auxiliary material roll to form a drug coating. The drug dispenser is a syringe pump, such as Figure 5-1 to Figure 5-6 As shown, one end of the syringe pump is connected to the drug fluid reserve and the other end is connected to the microfluidic device, and the drug fluid is delivered to the microfluidic device through the syringe pump.

[0055] The heating mechanism 5 is located below the conveyor belt. The heating mechanism is a ceramic heater used to heat the drug coating to make it amorphous. The stepper motor 7 is located at the end of the conveyor belt in the direction of travel. Figure 1 The middle conveyor belt transmits from left to right, and the stepper motor is used to control the moving speed of the auxiliary material roll.

[0056] An excipient roll with defined thickness and width is fed onto a conveyor belt, and then the drug is coated on the excipient roll using a drug dispenser and a microfluidic device, heated by a heating mechanism, and then the stepper motor rolls again to extrude the excipient roll together with a specific amount of drug API into a roll for normal oral administration and swallowing.

[0057] The auxiliary material roll is a film made of excipients or a commercially available film, and the thickness of the auxiliary material roll is uniform. The excipients include plasticizers, film formers, and additional additives. The bottom of the auxiliary material roll is an electrospun fiber or non-woven fabric or a wet-cast polymer matrix 1a, 1b, 1c, such as Figure 7 As shown, rolled into a cylindrical shape, Figure 6 As shown, there are many layers (approximately 3-5 meters depending on the application).

[0058] Embodiment 2:

[0059] A handheld coating extrusion device for storing personalized drug preparations, the structure of which is as described in Example 1, except that the number of drug dispensers is two. Multiple drug dispensers can be connected to multiple drug barrels, for example, barrel a can contain drug a, barrel b can contain drug b, and so on. Different drug barrels can contain different drugs, and different drug fluids are delivered to the microfluidic device together via different drug dispensers.

[0060] Embodiment 3:

[0061] A handheld coating extrusion device for storing personalized drug preparations, the structure of which is as described in Example 1, except that the microfluidic device is an L-shaped plate, the side wall of the plate is provided with an inlet horizontally, and nine channels are provided vertically in the plate, each channel has the same width, the channel outlet is downward, and the inlet is connected to the drug dispenser, such as Figures 4-1 to 4-5As shown in the figure, the drug fluid in the drug dispenser enters the channel from the inlet and flows downward through the channel onto the auxiliary material roll. It is used to evenly coat the drug fluid on the auxiliary material roll within a period of time.

[0062] Embodiment 4:

[0063] A handheld coating extrusion device for storing personalized pharmaceutical preparations has a structure as described in Example 3, except that an end plug is provided at the channel outlet. The coating width of the microfluidic channel can be controlled by changing the outlet of the microfluidic device.

[0064] Embodiment 5:

[0065] A handheld coating extrusion device for storing personalized drug preparations, the structure of which is as described in Example 3, except that a temperature sensor is provided in the channel of the microfluidic device and a temperature regulating device is provided on the side wall of the plate. A drug fluid with a settable temperature is delivered.

[0066] Embodiment 6:

[0067] A handheld coating extrusion device for storing personalized drug preparations, the structure of which is as described in Example 1, except that the handheld coating extrusion device for storing personalized drug preparations further includes a microcontroller, which is connected to the drug dispenser, the heating mechanism, the motor, and the stepping motor. Figure 3 As shown. The flow rate of the syringe pump, the heating temperature, and the motor speed are controlled by a microcontroller. The speed of the stepper motor is the same as that of the support mechanism motor. Both motors rotate at the same speed as the feed, and the rotation should be synchronized, otherwise perfect scrolling will not be formed.

[0068] The device is used to formulate personalized drug dosage, and the final concentration of the drug is defined as follows:

[0069] -Concentration of drug in the drug dispenser (to be applied)

[0070] - Speed ​​of drug dispensing

[0071] - Volume of drug dispensed

[0072] -The rotation speed of the auxiliary material roll

[0073] Dispensed drug (final formulation) = RPM (speed of stepper motor) * surface area of ​​dispensed auxiliary material roll (length * width (constant)) * flow rate * amount of dispensed drug.

Claims

1. A handheld coating extrusion device for storing personalized pharmaceutical preparations, characterized in that: It includes auxiliary material rolling mechanism, supporting mechanism, heating mechanism, medicine dispensing mechanism and stepping motor; The auxiliary material roll mechanism is used to provide auxiliary material rolls, and the supporting mechanism includes a conveyor belt. An auxiliary material roll mechanism is provided at one end of the conveyor belt, and the auxiliary material roll is placed above the conveyor belt; The drug dispensing mechanism comprises a drug dispenser and a microfluidic device, wherein the drug dispenser is used to deliver the drug fluid to be produced to the microfluidic device, and the microfluidic device is used to evenly lay the drug fluid to be produced on the auxiliary material roll to form a drug coating; the microfluidic device comprises at least two channels, each of which has the same width; the microfluidic device is an L-shaped plate, the side wall of the plate is provided with an inlet in the horizontal direction, the plate is provided with a channel in the vertical direction, the channel outlet is downward, and the inlet is connected to the drug dispenser; The heating mechanism is located under the conveyor belt and is used to heat the drug coating to make it amorphous; the stepper motor is located at the end of the conveyor belt in the direction of travel and is used to control the moving speed of the auxiliary material roll.

2. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that: The drug dispenser is a syringe pump, one end of which is connected to a drug fluid reservoir and the other end is connected to a microfluidic device.

3. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that: The channel outlet is provided with an end plug.

4. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that: A temperature sensor is provided in the channel of the microfluidic device, and a temperature regulating device is provided on the side wall of the plate.

5. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that: The heating mechanism is a ceramic heater.

6. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that: The supporting mechanism also includes a supporting frame, on which a transmission wheel is arranged, the transmission wheel is connected to the conveyor belt, and the transmission wheel is controlled to rotate by a motor.

7. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 6, characterized in that: The handheld coating extrusion device for storing personalized drug preparations also includes a microcontroller, which is connected to the drug dispenser, the heating mechanism, the motor, and the stepper motor.

8. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 7, characterized in that: The speed of the stepper motor is the same as the speed of the supporting mechanism motor.

9. The handheld coating extrusion device for storing personalized pharmaceutical preparations according to claim 2, characterized in that: The number of the drug dispenser is at least one.

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