A copper-source heterojunction nano antibacterial agent and its preparation method and application

By modifying the surface on the heterojunction of nanocup oxide and silver, and combining multiple antibacterial methods, a multifunctional copper-source heterojunction nanoantibacterial agent is formed, which solves the problem of poor killing of existing antibacterial agents on drug-resistant microorganisms and biofilms, and achieves efficient and economical antibacterial effects.

CN115671280BActive Publication Date: 2025-05-06ZHEJIANG UNIV
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Patent Information

Application Number
CN202211168104.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-23
Publication Date
2025-05-06
Estimated Expiration
2042-09-23

AI Technical Summary

Technical Problem

Existing antibacterial agents are difficult to effectively target drug-resistant bacteria, fungi and the biofilms they form, resulting in poor antibacterial effects and easily lead to enhanced microbial resistance.

Method used

By surface modification on the nanoheterojunction formed by copper oxide and silver nanoparticle oxide, combined with multiple antibacterial means such as photothermal, photodynamic, chemical reaction kinetics and silver ion release, a multifunctional copper source heterojunction nanoantibiotic agent is formed. The antibacterial agent can produce efficient photothermal effects under the irradiation of near-infrared laser light, and enhance the damage ability to biofilm through surface modifiers.

Benefits of technology

It has achieved efficient killing of drug-resistant bacteria, fungi and biofilms, reduced the generation of microbial resistance, and has low synthetic cost and simple preparation process, which is suitable for large-scale production and clinical applications.

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Abstract

The present invention discloses a copper-source heterojunction nano antibacterial agent, a preparation method and its application. The preparation method includes: 1) dispersing cuprous oxide nanoparticles synthesized by using a polymer template in water; 2) adding a silver nitrate aqueous solution to the solution obtained in 1) to react and obtain a copper-source nano heterojunction particle solution; 3) adding a surface modifier to the obtained solution to perform surface coating modification; 4) reacting to obtain coated copper-source nano heterojunction particles, or mixing them with auxiliary materials to obtain a copper-source heterojunction nano antibacterial agent. The present invention forms a nano heterojunction by forming a nano cuprous oxide with silver, and performs coating modification on the surface thereof, so as to achieve a combination of efficient photothermal, photodynamic, chemical reaction kinetics, silver ion and other multiple antibacterial means for, for example, drug-resistant bacteria, fungi and other microorganisms and biofilm infections formed by them, and can be applied to the treatment of infectious diseases such as eye microorganisms or skin microorganisms, and has excellent therapeutic effects.
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